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MARUYAMA Ikuro  丸山 征郎

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… Alternative Names

MARUYAMA IKUROU  丸山 征朗

丸山 征朗  マルヤマ イクロウ

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Researcher Number 20082282
Other IDs
External Links
Affiliation (Current) 2022: 鹿児島大学, 医歯学総合研究科, 特任教授
Affiliation (based on the past Project Information) *help 2015 – 2022: 鹿児島大学, 医歯学総合研究科, 特任教授
2017: 鹿児島大学, 大学院医歯学総合研究科, 特任教授
2013 – 2016: 鹿児島大学, 医歯(薬)学総合研究科, 教授
2012 – 2016: 鹿児島大学, 医歯(薬)学総合研究科, 特任教授
2013 – 2015: 鹿児島大学, 大学院医歯学総合研究科, 特任教授 … More
2014: 鹿児島大学, 医歯学総合研究科, 教授
2013: 鹿児島大学, 大学院医歯(薬)学総合研究科, 特任教授
2010 – 2012: Kagoshima University, 医歯学総合研究科, 特任教授
2010 – 2012: 鹿児島大学, 大学院・医歯学総合研究科, 特任教授
2011: 鹿児島大学, 大学院・医歯学総合研究科システム血栓制御学(メディポリス連携医学)講座, 特任講師
2011: 鹿児島大学, 大学院・医歯総合研究科, 特任教授
2010: 鹿児島大学, 医歯(薬)学総合研究科, 教授
2009: 鹿児島大学, 大学院・歯学総合研究科, 教授
2002 – 2009: Kagoshima University, Graduate School of Medicine and Dental Sciences, Professor, 大学院・医歯学総合研究科, 教授
2008: 鹿児島大学, 医歯(薬)学総合研究科, 教授
2006: Kagoshima University, Department of Laboratory and Molecular Medicine, Professor
2005 – 2006: 鹿児島大学, 大学院医歯学総合研究科, 教授
2001 – 2002: Kagoshima University, Faculty of Medicine, Professor, 歯学部, 教授
1992 – 2002: Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授
2001: 鹿児島大学, 医学部・臨床検査医学, 教授
1999: 鹿児島大学, 医学研究科, 教授
1999: 鹿児島大学, 歯学部, 教授
1994 – 1995: 鹿児島大学, 医学部・臨床検査医学講座, 教授
1993: 鹿児島大学, 医学部・, 教授
1993: 鹿児島大学, 医学部・臨床検査医学, 教授
1988 – 1991: 鹿児島大学, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Emergency medicine / Hematology / Laboratory medicine / Circulatory organs internal medicine / Hematology / Neurology / Anesthesiology/Resuscitation studies / Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
Except Principal Investigator
Emergency medicine / Laboratory medicine … More / Neurology / 病態科学系歯学(含放射線系歯学) / Circulatory organs internal medicine / 内科学一般 / Ophthalmology / Neurology / Veterinary medical science / Basic Section 52010:General internal medicine-related / Basic Section 55060:Emergency medicine-related / Biomedical engineering/Biological material science / Eating habits, studies on eating habits / Biological Sciences / Biomedical engineering/Biological material science / リハビリテーション科学 / Conservative dentistry / Digestive surgery / Medium-sized Section 52:General internal medicine and related fields / Basic Section 59040:Nutrition science and health science-related / Pathological medical chemistry / 内分泌・代謝学 / Hematology / Surgical dentistry / Periodontal dentistry / General internal medicine (including Psychosomatic medicine) / Digestive surgery / Applied health science / 膠原病・アレルギー・感染症内科学 / Pathological medical chemistry / General physiology / Human pathology / Laboratory medicine / Periodontal dentistry / General surgery / General surgery / Respiratory organ internal medicine / Neurosurgery / General internal medicine(including psychosomatic medicine) / Basic Section 59010:Rehabilitation science-related / Basic Section 42020:Veterinary medical science-related / Basic Section 56050:Otorhinolaryngology-related Less
Keywords
Principal Investigator
HMGB1 / トロンビン / DIC / トロンボモジュリン / PAMPs / PAMPs / DAMPs / Thrombomodulin / トロンビン受容体 / アポトーシス … More / ARDS / DAMPs / 血管内皮細胞 / 敗血症性ショック / HMG-1 / 感染症 / Histones / 糖尿病 / HMGB-1 / RAGE / 多臓器不全 / 循環器・高血圧 / 細胞・組織 / ショック / トロンボモデュリン / TLR-2 / TLR-4 / プロテインC / DAMP / RAMPs / thrombomodulin / protein C / ヒストン / Thrombin / 感染症性ショック / 敗血症 / アナンダマイド / anandamide / septic shock / エクソソーム / Exosome / exosome / 血小板 / 糖尿病合併症 / p38 / ASK / セレノプロテインP / EC-SOD / トロンボモヂュリン / TNFα / 細胞壊死 / 核内蛋白 / 個体死 / 細菌 / 微生物 / 病理学 / alarmin / エンドトキシン / CpG DNA / IL-1 / 侵襲 / 感染病 / inflammasome / PAR-1 / NF-kB / シグナル伝達 / 蛋白質 / 発現制御 / 血栓 / 止血学 / des-HMGB1 / ATP / PAMP / platelet / inflammation / ATP / Adenosine / Inflammasome / IL-1β / IL-18 / Alarmin / Shock / histones / NETs / レドックス状態 / ヒト化モノクローナル抗体 / HMGB1酸化還元型 / エピジェネティック / サイクリックAMP / プロスタサイクリン / TNF / ILーI / 動脈硬化 / 血栓症 / テラトカルチノ-マ / endothelial cells / cyclic AMP / cytokine / 培養血管内皮細胞 / 血管平滑筋細胞 / 冠動脈 / 冠動脈血栓症 / 冠動脈血栓〓 / endothelium / 腎系球体 / 膠原病 / Cultured Endothelilal Cells / Thrombin Receptor / Vascular Smooth Nusle Cells / Coronary Artery / Coronary Artery Thrombosis / MAPキナーゼ / アテローム / Thrombin receptor / MAP kinase / atherosclerosis / 内因性カンナビノイド / ショックのメディエーター / 妊娠中毒症 / エンドトキシンショック / ポリミキシンB / endocannabinoids / 2-arachidonylflyceorol / polymyxin B / 内因性マリファナ / 2-アラキドニールグリセロール / 急性肺障害(ALI) / 2-arachidonylglycerol(2-AG) / endocannabinoid / High Mobility Group Box-1 / endocannabinoides / 2-arachidonylglyceorol / ALI / ラディカル / 播種性血管内凝固症候群(DIC) / 救命 / 免疫学 / hrombomodulin / thromb in / ock / sprvqis / radical / microRNA / 糖鎖構造 / Heat shock protein / Alix / メラノーマ細胞株A375 / Organ failure / alarmins / RAMPs / 生体損傷 / 組織損傷 / 止血 / 修復 / TM / Protein C / EPCR / thrombin / 血流動態異常 / Skimming / Sludging / T-TAS / 血栓・塞栓 / 出血 / 血漿成分 / 血球成分 / Cancer Procoagulant / Thrombosis / Trousseau syndrome / blood skimming / blood sludging / 癌 / 血栓塞栓症 / 第Ⅶ因子 / 組織因子 / Blood skimming / Blood sludging / Thrombomodulin(TM) / sludging / skimming / shock … More
Except Principal Investigator
敗血症 / 血管内皮細胞 / HMGB1 / DAMPs / トロンボモジュリン / 血管新生 / アポトーシス / 炎症 / VEGF / 動脈硬化 / POEMS syndrome / サイトカイン / ヒストン / Crow-Fukase syndrome / platelet / 血栓 / DIC / NF-kB / 血栓症 / miRNA / HTLV-I / megakaryocyte / マクロファージ / IL-6 / 肝細胞癌 / microRNA / 一酸化窒素 / 炎症性サイトカイン / Rho-kinase / transgenic mouse / 血小板 / エンドセリン / 遺伝子治療 / 滑膜細胞 / トロンビン / NO / sepsis / lethality / HMGB-1 / 小胞体ストレス / β2-microglobulin / 肝癌 / 関節リウマチ / シノビオリン / 滑膜細胞増殖 / 転写制御 / E3ユビキチンリガーゼ / 集中治療医学 / thrombomodulin / ヌクレオフォスミン / アラーミン / 腫瘍 / 虚血性心疾患 / 冠動脈攣縮 / Angiogenesis / vascular endothelial growth factor / atherosclerosis / diabetic retinopathy / 平滑筋細胞 / 線維素溶解現象 / 血管壁収縮因子 / 血管壁弛緩因子 / 細胞接着分子 / EDRF / HTLV-I tax / アンチセンスオリゴ / 血管形成 / ずり応力 / 酸化LDL / NF-_KB / AP-1 / 宇宙飛行 / 1,5-AF / 1,5-AG / 歯周病 / アナンダマイド / 歯肉線維芽細胞 / ネクローシス / 歯周炎 / プロテオーム / 生体分子 / peptidome / proteome / inflammation / degradome / 酸化ストレス / 蛋白折り畳み異常 / RAGE / 食道癌 / 健康教育プログラム / 基質 / ノックアウトマウス / 慢性炎症 / 硝子体細胞 / 糖尿病 / 神経 / B細胞 / B cell / VEGF-A / 硝子体 / vitreous body / 網膜剥離 / 加齢黄斑変性 / ショック / DAMPs / 救急医学 / イヌ / メラノーマ / 乳腺腫瘍 / エクソゾーム / 単球 / マイクロRNA / 細胞外ヒストン / 受容体 / 血管平滑筋 / HAM / TSP / HTLV-I associated myelopathy / PACAP / Ca^<2+> / NF-κB / 血管平滑筋細胞 / LPS / Vascular smooth muscle cell / TEM / 抗血栓性 / Thrombomodulin / mRNA / 血管リモデリング / nitric oxide / bFGF / ヘパリン / マトリゲル / P-selectin / iNOS / 顎関節症 / Nitric Oxide / MRI / c-fos mRNA / 血管内皮機能 / ロキシスロマイシン / MMP / Roxithromycin / Porphyromonas gingivalis / gingipain / DX-9065a / MMP-1 / DNAマイクロアレイ / 内皮細胞 / TNFa / IL8 / ROS / IP6K-1 / anti-inflammatory peptide / 網膜色素上皮細胞 / 集中治療 / 腎炎 / 漢方薬 / 犬 / non-coding RNA / 成人T細胞白血病 / 関節炎 / トロンビン レセプター / DIC(播種性血管内凝固症候群) / 遊離トロンビン レセプター / 血管内皮細胞障害 / 血管平滑筋細胞増殖 / 電離放射線 / 細胞分化 / 神経細胞 / PC12 / HL-60 / 慢性関節リウマチ / 骨芽細胞 / HVJ-リポソーム法 / アンチセンス療法 / TNF-α / 細胞内カルシウム / トロンビン受容体 / プロテインC / HTLV-Itax / トランスフォーム / CREB / mRNA Differential Display / 無重力 / 筋萎縮 / 脊椎柱筋 / ヒートショック蛋白 / 筋アルドラーゼ / Myocyte Enhancer factor 2C / 口腔扁平上皮癌 / 予後因子 / 微少転移 / 一次リンパ節 / スズコロイド / Guided Bone Regeneration / anti-inflammatory oligonucleotide / decoy ODN / 異種移植 / クラウン系ミニブタ / クローンミニブタ / α-1,3-ガラクトース / 転移酵素 / ブタ内在性レトロウイルス(PERV) / 制御性T細胞 / α-1,3-ガラクトース転移酵素 / 内在性レトロウイルス(PERV) / gene targeting / 樹状細胞 / α-1,3-ガラクトース転移酸素 / Ascopyrone-P (APP) / HMGB1蛋白 / 敗血症・多臓器不全 / 低酸素・嫌気代謝 / APP / 嫌気 / HMGBI / 歯根膜細胞 / IL-11 / 歯肉上皮細胞 / 炎症性細胞浸潤 / 歯肉線維牙細胞 / 炎症抑制 / 歯肉溝滲出液 / 内因性カンナビノイド / レセプター / エンドトキシン / アスコパイロン-P / メイラード反応 / アポプトーシス / 抗炎症作用 / 細胞周期 / ペプチドーム / ペプチド / バイオマーカー / 質量分析 / 癌 / 検査 / 酵素 / 蛋白質 / peptide / biomarker / cancer / diagnosis / MOF / β2-ミクログロブリン / β2mミクログロブリ / ELISA / 臨床検査 / HCC / Esophageal ca / Carcinogenseis / 炎症と癌化 / ケモカイン / endothelial cell / health education / motivation / lifestyle / smoking / reactive hyperemia / 健康教育 / 食育 / 食教育 / 学童期 / 親子 / ESコビキチンリガーゼ / 転写複合体 / 線維化 / 分泌タンパク質 / コンディショナルノックアウト / 肝硬変 / 滑膜細胞細胞 / 分泌 / ユビキチン化 / 小胞体関連分解 / コンディショナルノックアウトマウス / 化合物 / 生化学的手法 / T細胞 / SDF-1 / 硝子体免疫 / 薬物治療 / 超音波 / 治療薬物 / プラットフォーム分子 / 補体 / 栄養学 / 脂質 / 代謝異常 / インスリン抵抗性 / 栄養教育 / 動脈硬化予防 / コミュニティー・オーガニゼーション / アディポサイトカイン / 免疫 / リンパ節 / 高内皮小静脈 / LPS tolerance / immune / lymph / spleen / iron / HEV / angiogenesis / immune system / nervus system / lymph node / high endothelial venule / mouse / 血栓形成 / ヒアルロン酸 / 細胞破壊物 / 硝子体手術 / histone / retina / hyaluronan / cell reaction / デグラドーム / 糖尿病網膜症 / 敗血症性ショック / バソプレシン / 免疫活性化 / ファゴサイトーシス / 次世代シーケンス / 腫瘍マーカー / 腫瘍治療 / 遺伝子導入 / リンパ腫 / p53遺伝子 / 免疫学 / 病理学 / TP53 / インフラマソーム / オートファジー / von Willebrand因子 / 血栓性微小血管障害症 / 外科系臨床医学 / 凝固 / 線維素溶解 / 増殖因子 / レトロウイルス / HTLV-I associated mylopathy / 成人T細胞白血病ウイルス / HTLVーI / HTLVーI脊髄症 / 脊髄症 / HTLVーI関連症候群 / シェグレン症候群 / HTLVーI筋炎 / Retrovirus / HTLV-1 tax遺伝子 / 単クローン性滑膜細胞 / 抗Fas抗体 / HTLV-Itax遺伝子 / HTLV-I tax遺伝子 / tax遺伝子 / 単球マクロファージ / HTLV-1 / retrovirus / flavivirus / apoptois / T cell receptor / ミトコンドリア脳筋症 / Fas抗原 / タイプ2筋線維萎縮 / DNA異常 / ミオパチー / 眼病変 / Fas mRNA / タイプ2筋線維 / ミトコンドリアDNA / 培養筋芽細胞 / 培養血管内皮細胞 / タイプ2線維 / Mitochondrial encephalomyopathy / Apoptosis / Fas antigen / Type 2 muscle fiber atrophy / DNA mutation / Myopathy / Ocular manifestations / インスリン分泌 / ランゲルハンス島 / オートクリン / 膵β細胞 / PACAP受容体 / サイクリックAMP / insulin secretion / islet / autocrine / beta-cells / PACAP receptor / 冠動脈血栓 / 心筋梗塞 / 細胞増殖因子 / 冠動脈硬化 / 冠動撃縮 / inflammatory cytokine / ischemic heart disease / arteriosclerosis / coronary spasm / coronary thrombosis / myocardial infarction / 転写因子 / マウス / アラミドシリコーン / エンドトキシンショック / 人工血管 / Artherosclerosis / Transcription factor / NF-kappaB / Genetherapy / Antisense oligo / Mouse / Aramid-silicon / アラミド・シリコーン樹脂 / 酸素透過性 / 気液法 / ミクロ相分離構造 / angle dependent-XPS / static-SIMS / ブロック共重合体 / シリコーン / 表面解析 / 熱機械特性他 / 生体適合性 / アラミドシリコーン樹脂 / マルチブロック共重合体 / 超薄膜 / 機械的特性 / 血液適合性 / 人工肺 / aramid-silicone resin / oxygen permeation / micro-domain structure / liquid-vapor method / angle dependent XPS / static SIMS / フラグメント / 固定化 / 表面プラズモン共鳴(SPR) / 医用材料 / human thrombomodulin / immobilization / antithrombogenicity / poly (ethylene) film / dialyzer / cellulose film / affinity interaction / surface plasmon resonance / 扁平上皮癌 / 腺癌 / MUC1ムチン / MUC2ムチン / MUC5ACムチン / シアル酸 / 癌患者の予後 / ムチン / 消化器癌 / in situ hybridization / 肺癌 / ムチン抗原 / Squamous cell carcinoma / Adenocarcinoma / MUC1 mucin / MUC2 mucin / MUC5AC mucin / Sialic acid / Prognosis of patient carrying cancer / 宇宙旅行 / ラット / 骨萎縮 / モデリング / 微小重力 / 微量元素 / クローニング / 傍背柱筋 / 萎縮 / ストレス蛋白 / MEF-2 / 骨モデリング / 椎体骨 / Diffential display / Space-flight / rat / bone atrophy / remodeling / microgravity / metal composition / cloning / 粥状動脈硬化 / 形質転換 / 接着分子 / リゾフォスファチジルコリン / CD36 / LOX-1 / 酸化LDL受容体 / Atherosclerosis / Vascular endothelial cell / Vasculogenesis / Phenotypic conversion / Adhesion molecule / Oxidized LDL / 低分子量G蛋白 / Rho-Kinase / 血管外膜 / 冠攣縮 / cytokines / atherosclerosis. / coronary artery spasm / vascular remodeling / small G proteins / gene therapy / オリゴ核酸 / ホスフォロチオエート / 角膜血管 / 管腔形成 / アンチセンス核酸 / 荷電 / FGF / ホスホロチオエ-ト / oligodeoxynucleotides / phosphorothioate / cornel vascular / Tube formation / antiseise oligodeoxynucleotides / 副作用 / 遅延型 / NF-KappaB / Nltric Oxide / 造影剤 / P-selectin、ICAM-1 / NF-κBの活性化 / 誘導型NO合成酵素(iNOS) / NOの生産 / P-selectin,ICAM-1 / 誘導型NO合成酵素(NOS) / NOの産生 / Adverse reaction / Late phase / Endothelial cells / NF-kappa B / nitruc oxide / Contrast media / 関節疼痛 / 関節円板後部組織 / MR画像 / エストロゲン / TMJ / Temporomandibular Joint Disorders / Joint Pain / Posterior Disk Attachment / MR Images / Estrogen / Cytokine / 血清 / TMD / serum / cytokine / 骨格筋のストレッチ / 筋特異的転写制御因子 / 筋力増強 / リハビリテーション医学 / 骨格筋の電気刺激 / ミオシンmRNA / 筋特異的遺伝子転写制御因子 / Stretch of Skeletal Muscle / Muscle Specific Transcription Factors / Muscle Strengthning / rehabilitation Medicine / 温熱療法 / サウナ浴 / 拡張型心筋症 / 心不全 / 心臓リハビリテーション / 脳性利尿ペプチド / 脳ナトリウム利尿ペプチド / 温熱性血管拡張療法 / thermal therapy / sauna bathing / endothelial function / dilated cardiomyopathy / heart failure / cardiac rehabilitation / brain natriuretic peptide / naked VEGF cDNA / neuropathy / nude mouse / matrix metalloproteinase / isoform / intraneural injection / coagulation / glioblastoma / Transgenic mouse / 血管内皮増殖因子 / 歯随炎 / 細胞外基質 / 覆罩 / 歯髄再生 / 歯槽骨再生 / in vivo / 歯髄炎 / 歯髄細胞 / tenascin / 遊走 / 分化 / アンチセンスオリゴヌクレオチド / chronic inflammation / pulpitis / periodontitis / extracellularmatrix / アンジオテンシンII / 冠動脈 / 虚血性心臓病 / Inflammation / Arteriosclerosis / Angiotensin II / Oxidative stress / 歯周病治療薬 / DX9065a / プロテアーゼ阻害剤 / 活性化血液凝固第X因子 / cDNAマイクロアレイ / KIAA 0263 / P.gingivalis / Periodontitis / Drug for periodontitis / VFGF / Crow-Rukase syndrome / 急性膵炎 / カンナビノイド / CB1受容体拮抗薬 / TNF-alpha / Acute pancreatitis / cannabinoid / anandamide / CBI receptor antagonist / 放射線感受性 / ミトコンドリア / 放射線応答遺伝子 / DNAアレイ法 / Radiosensitivity / Mitochondria / Radiation response gene / DNA array method / 肝発癌 / IL-8 / 活性酸素 / TNF / IL6 / TNF-a / 1L-8 / hepatocarcinogenesis / roxithromicin / 象牙質知覚過敏症 / 発症メカニズム / Dentin Hypersensitivity / DNA microarray / Mechanism / Crow-Fukase症候群 / POEMS症候群 / 骨髄巨核球 / 胎生致死 / embryonic lethality / 医療材料 / 高分子超薄膜 / 物理吸着 / ポリスルホン / 表面 / 産学官連携 / プロテインC活性 / Anticoagulant Activity / Biomedical Material / Polymeric thinfilm / Physical Adsorption / Polysulfone / Surface / Industry-University Alignment / 血液透析 / 透析アミロイド症 / hemodialysis / dialysis related amyloidosis / ER stress / unfolded protein resnonce / Crow-Fukase / POEMS / プロテオミクス / syndrome / 脳 / Syndrome / proteomics / brain / nerve / 肝虚血再灌流障害 / reperfusion injury / Liver / Rat / 基底膜 / invasionーMTTassay / 転移 / 浸潤 / 血行性転移 / 癌細胞 / 細胞膜 / モノクロ-ナル抗体 / 転移抑制 / Invasion Assay / 再構成基底膜 / MTT assay / レクチン / 細胞膜成分 / モノクローナル抗体 / basement membrane / MATRIGEL / invasion-MTT assay / metastasis / invasion / 単核球 / 画像処理 / 機械学習 / 画像 / 網膜色素上皮 / 脈絡膜 / 画像診断 / 網膜疾患 / 光干渉断層計 / ヒアロサイト / image analysis / vitrectomy / choroid / 自然免疫 / 呼吸器 / 炎症性肺疾患 / 膠原病関連間質性肺炎 / ホスホリパーゼA2 / 獲得免疫 / serotonin / hepatocellular carcinoma / exhaust platelet / prognosis / セロトニン / erythrocyte / apoptosis / program cell death / molecular clock / 赤血球 / eryptosis / programmed cell death / thrombosis / トランスレーショナルリサーチ / 細胞・組織 / シグナル伝達 / 生理学 / 白血球 / プログラム細胞死 / NETosis / 抗凝固薬 / ヘパリン起因性血小板減少症 / HIT / ポイントオブケア / ヘパリン起因性血小板減少症(HIT) / 血液凝固 / 播種性血管内凝固 / 全血血栓観測システム / 新規血液凝固検査 / T-TAS / 出血傾向 / 血液凝固検査 / 血栓形成観測システム / 獣医学 / クモ膜下出血 / 予防的運動 / 予防運動 / pre-conditioning / 脳血管攣縮 / 脳神経疾患 / 炎症制御 / 五苓散 / ノンコーディングRNA / エクソソーム / 犬腫瘍 / 診断・治療 / イヌ腫瘍 / エキソソーム / small RNA / 播種性血管内凝固症候群 / コンドロイチン硫酸 / p53 / 血管 / ASO / exosome / 核内タンパク質 / アイソフォーム / 抗体 / 播種性血管内凝固(DIC) / 治療 / 診断 / メディエーター / 組織損傷 / 老化 / klotho / AMPK / 脳卒中リハビリテーション / コンディショニング運動 / 脳神経保護 / 脳梗塞 / プレコンディショニング / 予防 / 認知症 / リハビリテーション / 脳梗塞モデル / コンディショニング / 有酸素運動 / 活動量 / 高齢者 / AI / micro vesicles / 腸内細菌叢 / メタボローム / 腸内細菌 / 喉頭気管粘膜 / 粘膜傷害抑制 / 気道粘膜再生 / マウス喉頭手術 Less
  • Research Projects

    (124 results)
  • Research Products

    (379 results)
  • Co-Researchers

    (224 People)
  •  circRNA-miRNAによる大動脈弁狭窄症病態解明とバイオマーカー創出の挑戦

    • Principal Investigator
      山口 宗一
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kagoshima University
  •  Research for damage suppression and regenerative therapy in vocal fold mucosa

    • Principal Investigator
      山下 勝
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56050:Otorhinolaryngology-related
    • Research Institution
      Kagoshima University
  •  Elucidating the pathophysiological factors for the clinical application using an artificial intelligence analysis to the snRNA transcriptome data of canine tumors

    • Principal Investigator
      三浦 直樹
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 42020:Veterinary medical science-related
    • Research Institution
      Kagoshima University
  •  腸内細菌叢制御による敗血症の代謝プロファイル再建戦略

    • Principal Investigator
      伊藤 隆史
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kumamoto University
  •  AMPKを介した抗酸化作用を有する新規機能性単糖による加齢黄斑変性の予防と治療

    • Principal Investigator
      寺崎 寛人
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kagoshima University
  •  時間軸・空間軸融合による血管炎症収束の制御機構解明ー「炎症性」血小板の新概念構築

    • Principal Investigator
      山口 宗一
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kagoshima University
  •  Klotho から見えてくる腎虚概念のlarge metabolic nexus

    • Principal Investigator
      大山 陽子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kagoshima University
  •  AMPK活性化作用を有する新規機能性単糖による運動機能の解析とその応用展開

    • Principal Investigator
      菊池 清志
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Kurume University
  •  脳梗塞前後のコンディショニングによる神経保護機序の解明と脳卒中リハビリへの応用

    • Principal Investigator
      榊間 春利
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59010:Rehabilitation science-related
    • Research Institution
      Kagoshima University
  •  The role of p53 in atherosclerosis

    • Principal Investigator
      Yamakuchi Munekazu
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 52:General internal medicine and related fields
    • Research Institution
      Kagoshima University
  •  Cellular and molecular mechanism of blood sludging/skimming. Causative role of cancer exosomes and their pathophysiological view pointsPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Kagoshima University
  •  Construction of A New Paradigm for Diagnosis and Treatment of Atherosclerosis Obliterans

    • Principal Investigator
      Yamakuchi Munekazu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Kagoshima University
  •  A novel therapeutic strategy targeting HMGB1 isoforms in sepsis

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Kagoshima University
  •  Research on the interaction of histones in pathophysiology of sepsis and its application

    • Principal Investigator
      Kawahara Ko-ichi
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55060:Emergency medicine-related
    • Research Institution
      Osaka Institute of Technology
  •  Can Kampo Medicines treat chronic kidney disease? : Challenge to elucidate the inflammation control mechanism of traditional herbal medicine

    • Principal Investigator
      OYAMA Yoko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      Kagoshima University
  •  Establishment of smart-diagnosis&treatment for canine tumor by exosome

    • Principal Investigator
      Miura Naoki
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      Kagoshima University
  •  Novel therapeutic proposal for DIC/Shock: from Damage-Sensing/-Control to Damage ResolutionPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Analysis for pro grammed cell death of anuclear platelets and erythrocytes for application of laboratory medicine

    • Principal Investigator
      Hashiguchi Teruto
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Pathophysiological significance of two types of DAMPs, naked- and exosomal type.Principal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Novel simulation technique for diagnosing heparin-induced thrombocytopenia (HIT)

    • Principal Investigator
      Ito Takashi
    • Project Period (FY)
      2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  The evaluation of novel examination of diagnosis of Disseminated intravascular coagulation (DIC) in dogs

    • Principal Investigator
      Iwanaga Tomoko
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Veterinary medical science
    • Research Institution
      Kagoshima University
  •  DAMPs as vasospasm and DCI after SAH.

    • Principal Investigator
      Kikuchi Kiyoshi
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurosurgery
    • Research Institution
      Kurume University
  •  The mechamism of novel alarmin

    • Principal Investigator
      Kawahara Ko-ichi
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Osaka Institute of Technology
  •  Construction of the system of

    • Principal Investigator
      Yamakuchi Munekazu
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Study of comprihensive vitreology

    • Principal Investigator
      SAKAMOTO Taiji
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Kagoshima University
  •  Proposal of novel concept, Exosome cargo as a novel DAMPs delivery systemPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Therapeutic strategy targeting extracellular histones in sepsis-associated DIC

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Young Scientists (A)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  The role of Endothelial miRNA in the regulation of vascular integrity

    • Principal Investigator
      Yamakuchi Munekazu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Multi-layered and topological regulatory system of PAMPs and DAMPs. Its relevance in various pathophysiology.Principal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  The analysis of inflammasome activation in extracellular histones

    • Principal Investigator
      Kawahara Ko-ihi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Osaka Institute of Technology
  •  Extracellular histones stimulate endothelial cells to release unusually-large von Willebrand factor multimer: mechanistic insight into the pathogenesis of lethal coagulopathy

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  PAMPs, DAMPs regulation by thrombomodulin(TM). Probable role of epithelial TMPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  The receptor and inhibitor of Nucleophosmin

    • Principal Investigator
      Kawahara Ko-ichi
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Osaka Institute of Technology
  •  Identification of novel canine tumor related microRNA for elucidating the pathology and clinical relevance

    • Principal Investigator
      Miura Naoki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      Kagoshima University
  •  Extracellular histones as a myocardial depressant factor

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Localization and regulation in reactive sites of DAMPs/PAMPs. Role of ATP from the activated platelesPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Innate immune responses and chronic inflammatory lung diseases

    • Principal Investigator
      Inoue Hiromasa
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Respiratory organ internal medicine
    • Research Institution
      Kagoshima University
  •  Study of biology and regulation of vitreous body

    • Principal Investigator
      SAKAMOTO Taiji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Kagoshima University
  •  HMGB1-induced vaspressin deficiency contributes to septic shock

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  A role of extracellular histones as mediators of death in sepsis

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Comprehensive regulatory system of PAMPs/DAMPs by TM-PC/EPCR systemPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Nucleophosmin: immunoactivity as a novel alarmin

    • Principal Investigator
      KAWAHARA Ko-ichi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Osaka Institute of Technology
  •  Cellular mechanism in thrombin mediated HMGB1 release. Effect of cluster formation of HMGB1 on the cell-surface receptors.Principal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Establishment and dynamism of des-HMGB1, degraded HMGB1 by thrombin-thrombomodulinPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  DAMPs : novel molecular targets for DIC therapy

    • Principal Investigator
      ITO Takashi
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Immunomodulatory effects ofB cell derivedVEGF-A in mice

    • Principal Investigator
      HASHIGUCHI Teruto
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  HMGB1の生体内分子修飾による機能変化・病態発現とその制御Principal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Development of a novel anti-inflammation effect in a Thrombomodulin as a platform type molecule

    • Principal Investigator
      KAWAHARA Ko-ichi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Osaka Institute of Technology
      Kagoshima University
  •  炎症性の生理活性をもつ“新規アディポサイトカインとしてのHMGB1"の提唱

    • Principal Investigator
      清水 利昭
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kagoshima University
  •  The education of arteriosclerosis prevention that enhanced family support and community support.

    • Principal Investigator
      IMAMURA Kayoko
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      Kagoshima Immaculate Heart University
  •  二元的アポトーシス制御因子シノビオリンを標的としたがん研究

    • Principal Investigator
      中島 利博
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Choju Medical Institute, Fukushimura Hospital.
  •  シノビオリンの二方向性シグナル制御の生物学的意義

    • Principal Investigator
      中島 利博
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Choju Medical Institute, Fukushimura Hospital.
  •  Integrated study on implication of Synoviolin in multiprocesses of rheumatoid arthritis.

    • Principal Investigator
      NAKAJIMA Toshihiro
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Tokyo Medical University
      Choju Medical Institute, Fukushimura Hospital.
  •  Defense system by thrombin-HMGB1 axisPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  Study of vitreous body : Analysis of microenvironmental control and development of novel treatment.

    • Principal Investigator
      SAKAMOTO Taiji
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Ophthalmology
    • Research Institution
      Kagoshima University
  •  Diagnostic value of peptidome analyses for protease activated pathological conditions beyond cancer diagnosis

    • Principal Investigator
      HASHIGUCHI Teruto
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Established the measurements methods of ER stress levels by using our new antibody.

    • Principal Investigator
      UCHIMURA Tomonori
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Identification of Perpetuating Factor for Liver Tissue Inflammation in Hepatic Carcinogenesis

    • Principal Investigator
      UENO Shinichi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Kagoshima University
  •  動脈硬化予防に用いる健康学習教材としての血管内皮細胞機能検査の有効性の検証

    • Principal Investigator
      大野 佳子
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Applied health science
    • Research Institution
      Kagoshima University
  •  壊死細胞由来の核由来生体レスキュー因子:"Alarmins"の概念のスケッチPrincipal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Implementation of the Health Education and Consideration of Physical Condition of Japanese School-age Children and Parents.

    • Principal Investigator
      IMAMURA Kayoko
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      Kagoshima Immaculate Heart University
  •  A new therapeutic concept for the treatment against sepsis using a functional material, 1,5-anhydrofructose

    • Principal Investigator
      ABEYAMA Kazuhiro
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Elucidation and reguration of the periodontal disease progression mechanism based on new inflammation adjustments(ANA and HMGB-1)

    • Principal Investigator
      IZUMI Yuichi
    • Project Period (FY)
      2006 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Tokyo Medical and Dental University
      Kagoshima University
  •  加熱食品由来の化学反応中間体を用いた生体機能分子修飾:新規創薬法の開発

    • Principal Investigator
      阿邉山 和浩
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General internal medicine (including Psychosomatic medicine)
    • Research Institution
      Kagoshima University
  •  A fundamental study on xenotransplantation

    • Principal Investigator
      TAKAO Sonshin
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kagoshima University
  •  凝固外因系と自然免疫系のクロストークとシナージズムPrincipal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  Thrombomodulin : As a regulator of multiple mediatorsPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  Evaluation of molecular mechanisms of dialysis related amyloidosis and the diagnosis method of early detection

    • Principal Investigator
      UCHIMURA Tomonori
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Proteomic analysis of Crow-Fukase syndrome

    • Principal Investigator
      HASHIGUCHI Teruto
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Kinetics of HMGB1 during ischemia-reperfusion injury of rat liver

    • Principal Investigator
      YAMANOI Akira, 小野 隆司
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Shimane University
  •  重症感染症における炎症誘導因子と致死性因子に対する同時性多重分子標的治療法の開発

    • Principal Investigator
      阿邊山 和浩
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Immobilization of human thrombomodulin onto polymeric thinfilms for biomedical material

    • Principal Investigator
      AKASHI Mitsuru
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Osaka University
  •  Newly development of functional low molecular therapeutics : Study of the pathomechanism of lethal multiple organ failure

    • Principal Investigator
      ABEYAMA Kazuhiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Investigations on pathomechanism, diagnosis and treatment in bacterial shock-For preposal of new padadigmPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Emergency medicine
    • Research Institution
      Kagoshima University
  •  Investigation of the unknown factor over stimulating the VEGF prodution in Crow-Fukase syndrome.

    • Principal Investigator
      HASHIGUCHI Teruto
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  "死のメディエーター":HMG-1の高感度測定と多臓器不全の診断法の確立Principal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  Radiation Sensitivity and Mitochondrial Related Responding Genes.

    • Principal Investigator
      MAJIMA Hideyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kagoshima University
  •  Fundamental research on identification and its control of the priming factor in liver cancer proliferation

    • Principal Investigator
      UENO Shinichi
    • Project Period (FY)
      2002 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      Kagoshima University
  •  Molecular biological analysis of dentin hypersensitivity

    • Principal Investigator
      TORII Mitsuo
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Conservative dentistry
    • Research Institution
      Kagoshima University
  •  新規レドックス制御因子:セレノプロテインPの機能とその分子病態Principal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kagoshima University
  •  Molecular and cellular basis of septic shock : Involvement of anandamide and HMG-1Principal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Anesthesiology/Resuscitation studies
    • Research Institution
      Kagoshima University
  •  Proposal of the new concept, "Platelet VEGF"

    • Principal Investigator
      HASHIGUCHI Teruto
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  A new thrapy for severe acute pancreatitis by regulating the cannabinoid

    • Principal Investigator
      TAKEDA Kazunori
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University
  •  口腔扁平上皮癌における予後因子の遺伝子学的、免疫組織学的検討と抗腫瘍効果について

    • Principal Investigator
      田畑 雅士
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kagoshima University
  •  プロテアーゼと新規受容体を介した神経細胞アポトーシスの分子細胞機構Principal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Basic and clinical studies on the role of inflammatory mechanisms in the pathogenesis ischemic heart disease

    • Principal Investigator
      SHIMOKAWA Hiroaki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University
  •  Development of a new therapy for periodontitis by regulation of proteinase cascades

    • Principal Investigator
      TORII Mitsuo, 松下 健二
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Periodontal dentistry
    • Research Institution
      Kagoshima University
  •  無重力下で誘導されるタイプI 筋萎縮関連新規遺伝子のクローニングと分子機能解析

    • Principal Investigator
      北島 勲
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Research for the pathogenesis and treatment of Crow-Fukase syndrome

    • Principal Investigator
      ARIMURA Kimiyoshi
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Application of vascular endothelial growth factor in conservative dentistry

    • Principal Investigator
      TORII Mitsuo
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Conservative dentistry
    • Research Institution
      KagoshimaUniversity
  •  Involvement of thrombin/thrombin receptor signaling in the development of vascular remodelingPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kagoshima University
  •  The Molecular Mechanism of Late Phase Adverse Reaction of Contrast Media

    • Principal Investigator
      NOIKURA Takenori
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kagoshima University
  •  Analysis of Angiogenesis for the Intra-Articular Lesions of Temporomandibular Joint Disorders by Mechanical Stress

    • Principal Investigator
      SATO Tsuyoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kagoshima University
  •  A study of NO in serum from patient with temporomandibular disorders

    • Principal Investigator
      HASEGAWA Hiroko, 奥 猛志
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kagoshima University
  •  MOLECULAR BIOLOGICAL RESEARCH ABOUT EFFECTS OF NEURONAL AND MUSCULAR REHABILITATION

    • Principal Investigator
      TANAKA Nobuyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      リハビリテーション科学
    • Research Institution
      KAGOSHIMA UNIVERSITY
  •  The Clinical Study for the Mechanism of Thermal Therapy to Patients with Chronic Heart Failure and Prognosis

    • Principal Investigator
      TEI Chuwa
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      リハビリテーション科学
    • Research Institution
      Kagoshima University
  •  Molecular Mechanism of Atherosclerosis

    • Principal Investigator
      KITA Toru
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      KYOTO UNIVERSITY
  •  Experimental and Clinical Studies on the Role of Inflammatory Mechanisms in the Pathogenesis of Ischemic Heart Disease

    • Principal Investigator
      SHIMOKAWA Horoaki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      KYUSHU UNIVERSITY
  •  Molecular constructions of oligodeoxynucleotides binding to bFGF targeting for angiogenesis

    • Principal Investigator
      KITAJIMA Isao
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kagoshima University
  •  動脈硬化の分子機構

    • Principal Investigator
      KITA Toru
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内分泌・代謝学
    • Research Institution
      Kyoto University
  •  電離放射線による細胞の分化とアポトーシスの分子機構に関する研究

    • Principal Investigator
      河野 一典
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      病態科学系歯学(含放射線系歯学)
    • Research Institution
      Kagoshima University
  •  トロンビン受容体遊離ペプチド高感度アッセイ系の確立と内皮細胞「活性化」の診断Principal Investigator

    • Principal Investigator
      丸山 征郎
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  関節リウマチの滑膜細胞増殖情報伝達機構解明とその制御によるアンチセンス療法開発

    • Principal Investigator
      北島 勲
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      内科学一般
    • Research Institution
      Kagoshima University
  •  HTLV-I tax遺伝子発現を介するアポトーシス誘導の分子生物学機構の解明Principal Investigator

    • Principal Investigator
      丸山 征郎, SHINMYOUZU Kohichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  Expression of new cell-cell adhesion molecule and mucin genes in cancers : its relationship with invasion or metastasis of cancers

    • Principal Investigator
      YONEZAWA Suguru
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Human pathology
    • Research Institution
      Kagoshima University
  •  Molecular cloning related to skeletal or muscle atrophy under microgravity

    • Principal Investigator
      KITAJIMA Isao
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Laboratory medicine
    • Research Institution
      Kagoshima University
  •  脳血栓準備状態の把握に関する研究-流血中遊離トロンビンレセプターの測定系の確立とその臨床応用-

    • Principal Investigator
      丸山 芳一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  The role of inflammatory mechanisms in the pathogenesis of ischemic heart disease. Basic and clinical studies.

    • Principal Investigator
      SHIMOKAWA Hiroaki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kyushu University
  •  Gene therapy for atherosclerosis by inhibition of nuclear transcriptional factor

    • Principal Investigator
      KITAJIMA Isao
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kagoshima University
  •  The development of the high-performance resin for medical use by using the multi-block copolymer of aramid and silicone

    • Principal Investigator
      SERIZAWA Takeshi, 明石 満
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kagoshima University
  •  A study on human thrombomodulin-immobilized antithrombogenic biomaterials

    • Principal Investigator
      AKASHI Mitsuru, 岸田 晶夫
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kagoshima University
  •  アンチセンスオリゴ法によるHTLV-I関連疾患に対する遺伝子調節治療法の開発

    • Principal Investigator
      KITAJIMA Isao
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kagoshima University
  •  Extraordinarily Potent Insulinotropin PACAP : Its Characterization as a Pancreatic Peptide and Action Mechanisms in Islet beta-Cells

    • Principal Investigator
      YADA Toshihiko
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General physiology
    • Research Institution
      Kagoshima University
  •  血管病変の成因究明を指向した血管内皮細胞の特性と機能に関する総合的研究

    • Principal Investigator
      室田 誠逸
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular Genetics Program in the Pathogenesis of Rheumatoid Arthritis Institute of Medical Science

    • Principal Investigator
      NISHIOKA Kusuki
    • Project Period (FY)
      1993 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      St.Marianna University School of Medicine
  •  Study of apoptosis in mitochondrial diseases

    • Principal Investigator
      NAKAGAWA Masanori
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Regulation of Expression of Thrombomodulin on the Cultured Human Umbilical Vein Endothelila Cells and Pathomechanism of ThrombosisPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      KAGOSHIMA UNIVERSITY
  •  血管病変の成因究明を指向した血管内皮細胞の特性と機能に関する総合的研究

    • Principal Investigator
      室田 誠逸
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  RESEARCH FOR THE PATHOMECHANISM, EPIDEMILOGY AND TREATMENTS FOR HAM AND HTLV-I RELATED DISORDERS.

    • Principal Investigator
      OSAME Mitsuhiro
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      KAGOSHIMA UNIVERSITY
  •  血管内皮細胞由来の血栓調節因子の機能解析

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  An Investigation of the Expression of Thrombomodulin in Cultured Human Umbilical Vein Endothelial CellsPrincipal Investigator

    • Principal Investigator
      MARUYAMA Ikuro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  血管内皮細胞由来の血栓調節因子の機能解析

    • Principal Investigator
      SUEISHI Katsuo
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  血管内皮細胞由来の血栓調節因子の機能解析

    • Principal Investigator
      居石 克夫
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyushu University
  •  Studies for Control of Metastasis Using Monoclonal Antibodies to Components of Blood-borne Metastatic Cancer Cells Surface

    • Principal Investigator
      SHIMAZU Hisaaki
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      Kagoshima University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] 血栓止血血管学2015

    • Author(s)
      一瀬白帝、丸山征郎、内山真一郎、山口宗一
    • Total Pages
      250
    • Publisher
      金芳堂
    • Data Source
      KAKENHI-PROJECT-15K15196
  • [Book] 血管内皮細胞研究フロンティア2004

    • Author(s)
      阿辺山和浩, 丸山征郎
    • Publisher
      血管内皮細胞による炎症・凝固系制御(炎症反応系と血液凝固系のクロストーク)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Book] 血管の発生と新生-基礎と臨床- 血小板性VEGF増多症としてのCrow-Fukase症候群2003

    • Author(s)
      橋口照人, 梅原藤雄, 有村公良, 丸山征郎
    • Publisher
      メディカルレビュー社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590901
  • [Book] 血管の発生と新生 -基礎と臨床- 血小板性VEGF増多症としてのCrow-Fukase症候群(p60-67)2003

    • Author(s)
      橋口照人, 梅原藤雄, 有村公良, 丸山征郎
    • Total Pages
      149
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-15590901
  • [Journal Article] E8002 Reduces Adhesion Formation and Improves Joint Mobility in a Rat Model of Knee Arthrofibrosis2022

    • Author(s)
      Takada Seiya、Setoyama Kentaro、Norimatsu Kosuke、Otsuka Shotaro、Nakanishi Kazuki、Tani Akira、Nakakogawa Tomomi、Matsuzaki Ryoma、Matsuoka Teruki、Sakakima Harutoshi、Tancharoen Salunya、Maruyama Ikuro、Tanaka Eiichiro、Kikuchi Kiyoshi、Uchikado Hisaaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Pages: 1-10

    • DOI

      10.3390/ijms23031239

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K19312, KAKENHI-PROJECT-20J14080, KAKENHI-PROJECT-20K11640
  • [Journal Article] Preconditioning exercise in rats attenuates early brain injury resulting from subarachnoid hemorrhage by reducing oxidative stress, inflammation, and neuronal apoptosis2021

    • Author(s)
      Otsuka Shotaro、Setoyama Kentaro、Takada Seiya、Nakanishi Kazuki、Terashi Takuto、Norimatsu Kosuke、Tani Akira、Sakakima Harutoshi、Maruyama Ikuro、Tancharoen Salunya、Tanaka Eiichiro、Kikuchi Kiyoshi
    • Journal Title

      Molecular neurobiology

      Volume: 58 Pages: 5602-5617

    • DOI

      10.1007/s12035-021-02506-7

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K19312, KAKENHI-PROJECT-20H04039, KAKENHI-PROJECT-20J14080, KAKENHI-PROJECT-20K11640
  • [Journal Article] Specific inhibition of α5 subunit-containing GABAA receptors enhances locomotor activity and neuronal activity in the motor cortex2021

    • Author(s)
      Otsuka Shotaro、Sakakima Harutoshi、Tani Akira、Nakanishi Kazuki、Takada Seiya、Norimatsu Kosuke、Maejima Hiroshi、Maruyama Ikuro
    • Journal Title

      Biomedical Research

      Volume: 226 Pages: 103-108

    • DOI

      10.1007/s00429-021-02317-5

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K19312, KAKENHI-PROJECT-20H04039, KAKENHI-PROJECT-20H04048, KAKENHI-PROJECT-20J14080
  • [Journal Article] 1,5-Anhydro-D-fructose Protects against Rotenone-Induced Neuronal Damage In Vitro through Mitochondrial Biogenesis2021

    • Author(s)
      Kasamo Yuki、Kikuchi Kiyoshi、Yamakuchi Munekazu、Otsuka Shotaro、Takada Seiya、Kambe Yuki、Ito Takashi、Kawahara Ko-ichi、Arita Kazunori、Yoshimoto Koji、Maruyama Ikuro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Pages: 1-16

    • DOI

      10.3390/ijms22189941

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K19312, KAKENHI-PROJECT-21H03037, KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-21K19454, KAKENHI-PROJECT-21K19544
  • [Journal Article] Endotheliopathy in septic conditions: mechanistic insight into intravascular coagulation2021

    • Author(s)
      Ito Takashi、Kakuuchi Midori、Maruyama Ikuro
    • Journal Title

      Critical Care

      Volume: 25 Pages: 95-95

    • DOI

      10.1186/s13054-021-03524-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02904
  • [Journal Article] Protective effects of recombinant human soluble thrombomodulin on ischemia reperfusion injury of spinal cord in rabbits2021

    • Author(s)
      Imagama I, Kawahara K, Ueno H, Maruyama I, Imoto H
    • Journal Title

      Medical Journal of Kagoshima University

      Volume: 73 Pages: 16-22

    • NAID

      120007001538

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02906
  • [Journal Article] Potential roles of 1,5-anhydro-d-fructose in modulating gut microbiome in mice2021

    • Author(s)
      Ito Takashi、Totoki Takaaki、Takada Seiya、Otsuka Shotaro、Maruyama Ikuro
    • Journal Title

      Scientific Reports

      Volume: 11 Pages: 19648-19648

    • DOI

      10.1038/s41598-021-99052-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21H03033
  • [Journal Article] Circulating Syndecan-1 as a Predictor of Persistent Thrombocytopenia and Lethal Outcome: A population Study of Patients With Suspected Sepsis Requiring Intensive Care2021

    • Author(s)
      Hatanaka Kosaku、Ito Takashi、Madokoro Yutaro、Kamikokuryo Chinatsu、Niiyama Shuhei、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
    • Journal Title

      Front Cardiovasc Med.

      Volume: 8 Pages: 730553-730553

    • DOI

      10.3389/fcvm.2021.730553

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21H03033, KAKENHI-PROJECT-20K09291
  • [Journal Article] Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial2020

    • Author(s)
      Ito Takashi、Maruyama Ikuro、Shimazaki Shuji、Yamamoto Yasuhiro、Aikawa Naoki、Hirayama Akio、Honda Goichi、Saito Hidehiko
    • Journal Title

      Research and Practice in Thrombosis and Haemostasis

      Volume: 4 Pages: 1141-1149

    • DOI

      10.1002/rth2.12419

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02904
  • [Journal Article] TLR4/MD-2 is a receptor for extracellular nucleophosmin 12020

    • Author(s)
      Nakatomi Kota、Ueno Hikari、Ishikawa Yuto、Salim Ronny、Mori Yuki、Kanemoto Issey、Tancharoen Salunya、Kikuchi Kiyoshi、Miura Naoki、Omori Taketo、Okuda?ashitaka Emiko、Matsumura Kiyoshi、Imaizumi Hitoshi、Motomiya Yoshihiro、Maruyama Ikuro、Kawahara Ko-Ichi
    • Journal Title

      Biomedical Reports

      Volume: 14 Pages: 1-6

    • DOI

      10.3892/br.2020.1397

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-18H02906
  • [Journal Article] E8002 Inhibits Peripheral Nerve Adhesion by Enhancing Fibrinolysis of l-Ascorbic Acid in a Rat Sciatic Nerve Model2020

    • Author(s)
      Kikuchi Kiyoshi、Setoyama Kentaro、Takada Seiya、Otsuka Shotaro、Nakanishi Kazuki、Norimatsu Kosuke、Tani Akira、Sakakima Harutoshi、Kawahara Ko-ichi、Hosokawa Kazuya、Kiyama Ryoji、Sumizono Megumi、Tancharoen Salunya、Maruyama Ikuro、Hattori Gohsuke、Morioka Motohiro、Tanaka Eiichiro、Uchikado Hisaaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Pages: 3972-3972

    • DOI

      10.3390/ijms21113972

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K11640, KAKENHI-PROJECT-18K08955
  • [Journal Article] Recombinant thrombomodulin alleviates oxidative stress without compromising host resistance to infection in rats infected with methicillin-resistant Staphylococcus aureus2020

    • Author(s)
      Ito Takashi、Shrestha Binita、Kakihana Yasuyuki、Maruyama Ikuro
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 17413-17413

    • DOI

      10.1038/s41598-020-74529-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02904
  • [Journal Article] Leukocyte-derived extracellular DNA contributes to abnormal pressure elevation in the extracorporeal circulation circuit2020

    • Author(s)
      Yashima Nozomi、Ito Takashi、Kajiyama Kenji、Maeda Hiroyuki、Kakihana Yasuyuki、Maruyama Ikuro
    • Journal Title

      Scientific Reports

      Volume: 10

    • DOI

      10.1038/s41598-019-57173-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18K19587
  • [Journal Article] Dynamics of Soluble Thrombomodulin and Circulating miRNAs in Patients with Atrial Fibrillation Undergoing Radiofrequency Catheter Ablation.2019

    • Author(s)
      Namino F, Yamakuchi M, Iriki Y, Okui H, Ichiki H, Maenosono R, Oketani N, Masamoto I, Miyata M, Horiuchi M, Hashiguchi T, Ohishi M, Maruyama I
    • Journal Title

      Clin Appl Thromb Hemost.

      Volume: 25 Pages: 107602961985157-107602961985157

    • DOI

      10.1177/1076029619851570

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09593, KAKENHI-PROJECT-19K17608, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Circulating histone H3 levels in septic patients are associated with coagulopathy, multiple organ failure, and death: a single-center observational study.2019

    • Author(s)
      Yokoyama Yayoi、Ito Takashi、Yasuda Tomotsugu、Furubeppu Hiroaki、Kamikokuryo Chinatsu、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
    • Journal Title

      Thromb J.

      Volume: 17 Pages: 1-1

    • DOI

      10.1186/s12959-018-0190-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Generation of the heterogeneity of extracelluar vesicles by membrane organization and sortin machineries.2019

    • Author(s)
      Harada Yoichiro、Suzuki Takehiro、Fukushige Tomoko、Kizuka Yasuhiko、Yagi Hirokazu、Yamamoto Mika、Kondo Kiyotaka、Inoue Hiromasa、Kato Koichi、Taniguchi Naoyuki、Kanekura Takuro、Dohmae Naoshi、Maruyama Ikuro
    • Journal Title

      Biochim Biophys Acta Gen Subj.

      Volume: 1863 Pages: 681-691

    • DOI

      10.1016/j.bbagen.2019.01.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K07356, KAKENHI-PROJECT-18K06914, KAKENHI-PLANNED-17H06414, KAKENHI-PROJECT-15K14481, KAKENHI-PROJECT-15H04700, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] N-glycome inheritance from cells to extracellular vesicles in B16 melanomas.2019

    • Author(s)
      Harada Yoichiro、Kizuka Yasuhiko、Tokoro Yuko、Kondo Kiyotaka、Yagi Hirokazu、Kato Koichi、Inoue Hiromasa、Taniguchi Naoyuki、Maruyama Ikuro
    • Journal Title

      FEBS Lett.

      Volume: 印刷中 Pages: 942-951

    • DOI

      10.1002/1873-3468.13377

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K07356, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Serum histone H3 levels and platelet counts are potential markers for coagulopathy with high risk of death in septic patients: a single-center observational study.2019

    • Author(s)
      Ito Takashi、Totoki Takaaki、Yokoyama Yayoi、Yasuda Tomotsugu、Furubeppu Hiroaki、Yamada Shingo、Maruyama Ikuro、Kakihana Yasuyuki
    • Journal Title

      J Intensive Care.

      Volume: 7 Pages: 63-63

    • DOI

      10.1186/s40560-019-0420-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Application of high-mannose-type glycan-specific lectin from Oscillatoria Agardhii for affinity isolation of tumor-derived extracellular vesicles.2019

    • Author(s)
      Yamamoto Mika、Harada Yoichiro、Suzuki Takehiro、Fukushige Tomoko、Yamakuchi Munekazu、Kanekura Takuro、Dohmae Naoshi、Hori Kanji、Maruyama Ikuro
    • Journal Title

      Anal Biochem.

      Volume: 580 Pages: 21-29

    • DOI

      10.1016/j.ab.2019.06.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K08272, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02734, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19523, KAKENHI-PROJECT-18K19587
  • [Journal Article] Effects of glycemic control and hypoglycemia on Thrombus formation assessed using automated microchip flow chamber system: an exploratory observational study2019

    • Author(s)
      Yamamoto K, Ito T, Nagasato T, Shinnakasu A, Kurano M, Arimura A, Arimura H, Hashiguchi H, Deguchi T, Maruyama I, Nishio Y.
    • Journal Title

      Thrombosis Journal

      Volume: 17

    • DOI

      10.1186/s12959-019-0206-8

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Immunological evidence for in vivo production of novel advanced glycation end-products from 1,5-anhydro-D-fructose, a glycogen metabolite.2019

    • Author(s)
      Sakasai-Sakai Akiko、Takata Takanobu、Suzuki Hirokazu、Maruyama Ikuro、Motomiya Yoshihiro、Takeuchi Masayoshi
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 10194-10194

    • DOI

      10.1038/s41598-019-46333-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K11003, KAKENHI-PROJECT-18K11139, KAKENHI-PROJECT-16H01811, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Comparison between blood coagulability in the intra-atrial and peripheral regions during the acute phase after rapid atrial pacing.2019

    • Author(s)
      Yamada S, Hirao D, Miura N, Iwanaga T, Kawaguchi T, Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R.
    • Journal Title

      Experimental Animals

      Volume: Oct 31 Issue: 2 Pages: 137-146

    • DOI

      10.1538/expanim.18-0100

    • NAID

      130007642989

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08054, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-17H03926, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-16H05845
  • [Journal Article] Recombinant Thrombomodulin Suppresses Histone-Induced Neutrophil Extracellular Trap Formation.2019

    • Author(s)
      Shrestha Binita、Ito Takashi、Kakuuchi Midori、Totoki Takaaki、Nagasato Tomoka、Yamamoto Mika、Maruyama Ikuro
    • Journal Title

      Front Immunol.

      Volume: 10 Pages: 2535-2535

    • DOI

      10.3389/fimmu.2019.02535

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02904, KAKENHI-PROJECT-16K10746, KAKENHI-PROJECT-18K19587
  • [Journal Article] Application of a Novel Anti-Adhesive Membrane, E8002, in a Rat Laminectomy Model.2018

    • Author(s)
      Kikuchi K, Setoyama K, Terashi T, Sumizono M, Tancharoen S, Otsuka S, Takada S, Nakanishi K, Ueda K, Sakakima H, Kawahara KI, Maruyama I, Hattori G, Morioka M, Tanaka E, Uchikado H.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 19(5) Pages: 1-9

    • DOI

      10.3390/ijms19051513

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-18H02906, KAKENHI-PROJECT-16K10746
  • [Journal Article] Circulating activated protein C levels are not increased in septic patients treated with recombinant human soluble thrombomodulin2018

    • Author(s)
      Arishima Takuro、Ito Takashi、Yasuda Tomotsugu、Yashima Nozomi、Furubeppu Hiroaki、Kamikokuryo Chinatsu、Futatsuki Takahiro、Madokoro Yutaro、Miyamoto Shotaro、Eguchi Tomohiro、Haraura Hiroyuki、Maruyama Ikuro、Kakihana Yasuyuki
    • Journal Title

      Thrombosis Journal

      Volume: 16 Pages: 24-24

    • DOI

      10.1186/s12959-018-0178-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-17H04363
  • [Journal Article] Circulating histone H3 levels are increased in septic mice in a neutrophil-dependent manner: preclinical evaluation of a novel sandwich ELISA for histone H32018

    • Author(s)
      Ito Takashi、Nakahara Mayumi、Masuda Yoshiki、Ono Sachie、Yamada Shingo、Ishikura Hiroyasu、Imaizumi Hitoshi、Kamikokuryo Chinatsu、Kakihana Yasuyuki、Maruyama Ikuro
    • Journal Title

      Journal of Intensive Care

      Volume: 6 Pages: 79-79

    • DOI

      10.1186/s40560-018-0348-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-18H02904
  • [Journal Article] Comparison of chronological changes in blood characteristics in the atrium and peripheral vessels after the development of non-valvular atrial fibrillation2018

    • Author(s)
      Yamada S,Hirao D, Miura N, Iwanaga T, Kawaguchi T,Yoshimura A, Oomori T, Nagasato T, Maruyama I, Fukushima R
    • Journal Title

      Thromb Res

      Volume: 171 Pages: 31-37

    • DOI

      10.1016/j.thromres.2018.09.040

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08054, KAKENHI-PROJECT-18K19587, KAKENHI-PROJECT-16H05845
  • [Journal Article] HMGB proteins and arthritis.2018

    • Author(s)
      Taniguchi N, Kawakami Y, Maruyama I, Lotz M.
    • Journal Title

      Hum Cell.

      Volume: 31(1) Pages: 1-9

    • DOI

      10.1007/s13577-017-0182-x

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04363, KAKENHI-PROJECT-15K10484, KAKENHI-PROJECT-18K09036
  • [Journal Article] Uric acid enhances alteplase-mediated thrombolysis as an antioxidant.2018

    • Author(s)
      Kikuchi K, Setoyama K, Tanaka E, Otsuka S, Terashi T,Nakanishi K, Takada S, Sakakima H, Ampawong S, Kawahara KI, Nagasato T, Hosokawa K, Harada Y, YamamotoM, Kamikokuryo C, Kiyama R, Morioka M, Ito T, Maruyama I, Tancharoen S.
    • Journal Title

      Scientific Reports

      Volume: 8(1) Pages: 1-12

    • DOI

      10.1038/s41598-018-34220-1

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-18H02906, KAKENHI-PROJECT-16K10746
  • [Journal Article] 敗血症における血栓形成の生理と病理2017

    • Author(s)
      八島望, 伊藤隆史, 垣花泰之, 丸山征郎
    • Journal Title

      日本外科感染症学会雑誌

      Volume: 14 Pages: 705-711

    • Data Source
      KAKENHI-PROJECT-15H05684
  • [Journal Article] Edaravone, a Synthetic Free Radical Scavenger, Enhances Alteplase-Mediated Thrombolysis2017

    • Author(s)
      Kikuchi K, Setoyama K, Kawahara KI, Nagasato T, Terashi T, Ueda K, Nakanishi K, Otsuka S, Miura N, Sameshima H, Hosokawa K,Harada Y, Shrestha B, Yamamoto M, Morimoto-Yamashita Y, Kikuchi H, Kiyama R, Kamikokuryo C, Tancharoen S, Sakakima H, Morioka M, Tanaka E, Ito T, Maruyama I.
    • Journal Title

      Oxid Med Cell Longev.

      Volume: Article ID 6873281 Pages: 14-14

    • DOI

      10.1155/2017/6873281

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-15H05684
  • [Journal Article] Decreased Expression of Thrombomodulin in Endothelial Cells by Fibroblast Growth Factor-23/α-Klotho.2017

    • Author(s)
      Tanaka K, Salunya T, Motomiya Y, Motomiya Y, Oyama Y, Yamakuchi M, Maruyama I.
    • Journal Title

      Ther Apher Dial

      Volume: 21(4) Pages: 395-404

    • DOI

      10.1111/1744-9987.12524

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Journal Article] Potential diagnostic markers for disseminated intravascular coagulation of sepsis.2016

    • Author(s)
      Toshiaki Iba, Takashi Ito, Ikuro Maruyama, Bernd Jilma, Thorsten Brenner, Marcella C.A. Muller, Nicole P. Juffermans, Jecko Thachil
    • Journal Title

      Blood Rev.

      Volume: 30 Pages: 149-155

    • DOI

      10.1016/j.blre.2015.10.002

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05684, KAKENHI-PROJECT-25462831, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-26293385
  • [Journal Article] HMGB1 Promotes Intraoral Palatal Wound Healing through RAGE-Dependent Mechanisms.2016

    • Author(s)
      Tancharoen S, Gando S, Binita S, Nagasato T, Kikuchi K, Nawa Y, Dararat P, Yamamoto M, Narkpinit S, Maruyama I.
    • Journal Title

      Int J Mol Sci

      Volume: 17(11)

    • DOI

      10.3390/ijms17111961

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-16K15763
  • [Journal Article] HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin.2016

    • Author(s)
      Shimizu T, Yamakuchi M, Biswas KK, Aryal B, Yamada S, Hashiguchi T, Maruyama I.
    • Journal Title

      Obesity (Silver Spring)

      Volume: 24(9) Pages: 1913-21

    • DOI

      10.1002/oby.21549

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-16K15763
  • [Journal Article] Thrombomodulin as an intravascular safeguard against inflammatory and thrombotic diseases2016

    • Author(s)
      Takashi Ito, Yasuyuki Kakihana & Ikuro Maruyama
    • Journal Title

      Expert Opinion on Therapeutic Targets

      Volume: 20 Pages: 151-158

    • DOI

      10.1517/14728222.2016.1086750

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05684
  • [Journal Article] Upregulation of non-βCell-derived Vascular Endothelial Growth Factor A Increases Small Clusters of Insulin-producing Cells in the Pancreas2015

    • Author(s)
      Takenouchi K, Shrestha B, Yamakuchi M, Yoshinaga M, Arimura N, Kawaguchi H, Nagasato T, Feil R, Kawahara K-I, Sakamoto T, Maruyama I, Hashiguchi T.
    • Journal Title

      PLoS One

      Volume: in press Pages: 308-15

    • DOI

      10.1055/s-0034-1371811

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293130
  • [Journal Article] Secondhand smoke exposure-induced nucleocytoplasmic shuttling of HMGB1 in a rat premature skin aging model.2015

    • Author(s)
      Chaichalotornkul S, Nararatwanchai T, Narkpinit S, Dararat P, Kikuchi K, Maruyama I, Tancharoen S.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 456(1) Pages: 92-7

    • DOI

      10.1016/j.bbrc.2014.11.040

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-26670790
  • [Journal Article] Gene transfer of high-mobility group box 1 box-A domain in a rat acute liver failure model.2015

    • Author(s)
      Tanaka, M
    • Journal Title

      J Surg Res.

      Volume: 194 Pages: 571-580

    • DOI

      10.1016/j.jss.2014.11.022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591888, KAKENHI-PROJECT-26670790, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-26293385
  • [Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β2015

    • Author(s)
      Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
    • Journal Title

      EMBO J

      Volume: 34 Pages: 1042-1042

    • DOI

      10.15252/embj.201489897

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-26461478, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293385
  • [Journal Article] Cleavage of host cytokeratin-6 by lysine-specific gingipain induces gingival inflammation in periodontitis patients.2015

    • Author(s)
      Tancharoen S, Matsuyama T, Kawahara K, Tanaka K, Lee LJ, Machigashira M, Noguchi K, Ito T, Imamura T, Potempa J, Kikuchi K,Maruyama I.
    • Journal Title

      PLOS ONE.

      Volume: 10

    • DOI

      10.1371/journal.pone.0117775

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26670790, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-25460498
  • [Journal Article] Structure and function of Thrombomodulin, a molecule which expressed on the endothelial cell surface and acts as anti-thrombogenic and antiinflammatory in the closed circulatory system2015

    • Author(s)
      Maruyama I.
    • Journal Title

      Seikagaku.

      Volume: 87(2) Pages: 188-93

    • NAID

      40020461501

    • Data Source
      KAKENHI-PROJECT-26293385
  • [Journal Article] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment.2014

    • Author(s)
      Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T, Nakamura M, Sakamoto T.
    • Journal Title

      Lab Invest.

      Volume: 94(5) Pages: 569-585

    • DOI

      10.1038/labinvest.2014.46

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390396, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659765, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25670763, KAKENHI-PROJECT-26293385, KAKENHI-PROJECT-26670789
  • [Journal Article] Antithrombotic effects of PAR1 and PAR4 antagonists evaluated under flow and static conditions.2014

    • Author(s)
      Hosokawa K, Ohnishi T, Miura N, Sameshima H, Koide T, Tanaka KA, Maruyama I
    • Journal Title

      Thromb Res

      Volume: 133(1) Pages: 66-72

    • DOI

      10.1016/j.thromres.2013.10.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25670764
  • [Journal Article] Overexpression of receptor for advanced glycation end products and high-mobility group box 1 in human dental pulp inflammation.2014

    • Author(s)
      Tancharoen S, Tengrungsun T, Suddhasthira T, Kikuchi K, Vechvongvan N, Tokuda M, Maruyama I.
    • Journal Title

      Mediators Inflamm.

      Volume: 2014 Pages: 754069-754069

    • DOI

      10.1155/2014/754069

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26670790
  • [Journal Article] Comparative evaluation of direct thrombin and factor Xa inhibitors with antiplatelet agents under flow and static conditions: an in vitro flow chamber model.2014

    • Author(s)
      Hosokawa K, Ohnishi T, Sameshima H, Miura N, Koide T, Maruyama I, Tanaka KA
    • Journal Title

      PLoS One

      Volume: 9(1) Pages: 86491-86491

    • DOI

      10.1371/journal.pone.0086491

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25670764
  • [Journal Article] HMGB1 promotes the development of pulmonary arterial hypertension in rats.2014

    • Author(s)
      Sadamura-Takenaka Y, Ito T, Noma S, Oyama Y, Yamada S, Kawahara K, Inoue H, Maruyama I.
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0102482

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-25293192, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26670793
  • [Journal Article] Hemoadsorption of high-mobility group box chromosomal protein 1 using a column for large animals.2014

    • Author(s)
      Nishiyama R, Shinoda M, Tanabe M, Oshima G, Takano K, Miyasho T, Fuchimoto Y, Yamada S, Inoue T, Shimada K, Suda K, Tanaka M, Hayashida T, Yagi H, Kitago M, Obara H, Itano O, Takeuchi H, Kawachi S, Maruyama I, Kitagawa Y
    • Journal Title

      European Surgical Research

      Volume: 51(3-4) Pages: 181-190

    • DOI

      10.1159/000357563

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591875, KAKENHI-PROJECT-24591888, KAKENHI-PROJECT-24659804
  • [Journal Article] Hyaluronan protection of corneal endothelial cells against extracellular histones after Phacoemulsification.2014

    • Author(s)
      Kawano H, Sakamoto T, Ito T, Miyata K, Hashiguchi T, Maruyama I.
    • Journal Title

      J Cataract Refract Surg.

      Volume: 40 Pages: 704-711

    • DOI

      10.1016/j.jcrs.2014.07.026

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24659765, KAKENHI-PROJECT-26670789, KAKENHI-PROJECT-26670790
  • [Journal Article] Toxic effects of extracellular histones and their neutralization by vitreous in retinal detachment2014

    • Author(s)
      Kawano H, Ito T, Yamada S, Hashiguchi T, Maruyama I, Hisatomi T, Nakamura M, Sakamoto T
    • Journal Title

      Lab Invest

      Volume: 94(5) Pages: 569-85

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670763
  • [Journal Article] Recombinant thrombomodulin protects mice against histone-induced lethal thromboembolism2013

    • Author(s)
      Nakahara M, Ito T, et al.
    • Journal Title

      PLoS One.

      Volume: 8(9) Pages: 75961-75961

    • DOI

      10.1371/journal.pone.0075961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659700, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25670763, KAKENHI-PROJECT-25670764
  • [Journal Article] Analysing responses to aspirin and clopidogrel by measuring platelet thrombus formation under arterial flow conditions.2013

    • Author(s)
      Hosokawa K, Ohnishi T, Sameshima H, Miura N, Ito T, Koide T, Maruyama I
    • Journal Title

      Thromb Haemost.

      Volume: 109(1) Pages: 102-11

    • DOI

      10.1160/th12-06-0441

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659798, KAKENHI-PROJECT-24659804
  • [Journal Article] Preventive effects of Morus alba L. anthocyanins on diabetes in Zucker diabetic fatty rats2013

    • Author(s)
      Sarikaphuti A, Nararatwanchai T, Hashiguchi T, Ito T, Thaworanunta S, Kikuchi K, Oyama Y, Maruyama I, Tancharoen S
    • Journal Title

      Exp Ther Med

      Volume: 6(3) Pages: 689-695

    • URL

      http://www.spandidos-publications.com/etm/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Journal Article] Saturated fatty acid palmitate induces extracellular release of histone H3: a possible mechanistic basis for high-fat diet-induced inflammation and thrombosis.2013

    • Author(s)
      Shrestha C, Ito T, et al.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437(4) Pages: 573-578

    • DOI

      10.1016/j.bbrc.2013.06.117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12F02424, KAKENHI-PROJECT-24659282, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25293132, KAKENHI-PROJECT-25670764
  • [Journal Article] Coagulation activity and white thrombus formation in the microminipig2013

    • Author(s)
      Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Sameshima H, Miyoshi N, Tanimoto A, Maruyama I
    • Journal Title

      In Vivo

      Volume: 27(3) Pages: 357-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Coagulation activity and white thrombus formation in the microminipig2013

    • Author(s)
      Miura N, Kawaguchi H, Nagasato T, Yamada T, Ito T, Izumi H, Shameshima H, Miyoshi N, Tanimoto A, Maruyama I
    • Journal Title

      In Vivo

      Volume: 27(3) Pages: 357-61

    • URL

      http://iv.iiarjournals.org

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Journal Article] Neutrophil elastase inhibitor improves survival rate after ischemia reperfusion injury caused by supravisceral aortic clamping in rats2013

    • Author(s)
      Fujimura N, Obara H, Suda K, Takeuchi H, Miyasho T, Kawasako K, Du W, Yamada S, Ono S, Matsumoto K, Matsuda S, Yagi H, Kitago M, Shinoda M, Itano O, Tanabe M, Sakamoto M, Maruyama I, Kitagawa Y
    • Journal Title

      J Surg Res

      Volume: 180(1) Pages: 31-36

    • DOI

      10.1016/j.jss.2012.04.037

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591875, KAKENHI-PROJECT-24591888
  • [Journal Article] Potential of the angiotensin receptor blockers (ARBs) telmisartan, irbesartan, and candesartan for inhibiting the HMGB1/RAGE axis in prevention and acute treatment of stroke.2013

    • Author(s)
      Kikuchi K, Tancharoen S, Ito T, Morimoto-Yamashita Y, Miura N, Kawahara K, MaruyamaI, Murai Y, Tanaka E
    • Journal Title

      Int J Mol Sci

      Volume: 14 Pages: 18899-18924

    • DOI

      10.3390/ijms140918899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590269, KAKENHI-PROJECT-24390402, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25305032
  • [Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma.2013

    • Author(s)
      Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara K, Maruyama I, Arita K
    • Journal Title

      Brain Tumor Pathol.

      Volume: 30(1) Pages: 28-33

    • DOI

      10.1007/s10014-012-0095-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-24659804, KAKENHI-PROJECT-25305032
  • [Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism2013

    • Author(s)
      Nakahara M, Ito T, Kawahara K, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
    • Journal Title

      PLoS One

      Volume: 8(9)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25670763
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Ishii J, Kitagawa F, Yamada S, Hattori K, Okumura M, Naruse H, Motoyama S, Matsui S, Tanaka I, Izawa H, Maruyama I, Nomura M, Ozaki Y
    • Journal Title

      Atherosclerosis

      Volume: 221(2) Pages: 490-5

    • DOI

      10.1016/j.atherosclerosis.2012.01.040

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Efficacy of MK615 for the treatment of patients with liver disorders2012

    • Author(s)
      Hokari A, Ishikawa T, Tajiri H, Matsuda T, Ishii O, Matsumoto N, Okuse C, Takahashi H, Kurihara T, Kawahara K, Maruyama I, Zeniya M
    • Journal Title

      World J Gastroenterol

      Volume: 18(31) Pages: 4118-26

    • DOI

      10.3748/wjg.v18.i31.4118

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Maruyama I, Ozaki Y., et al
    • Journal Title

      Atherosclerosis

      Volume: 221 Pages: 490-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012

    • Author(s)
      Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
    • Journal Title

      Atherosclerosis

      Volume: 224 Pages: 511-4

    • DOI

      10.1016/j.atherosclerosis.2012.07.027

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591069, KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591425, KAKENHI-PROJECT-23790410, KAKENHI-PROJECT-24659804
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2012

    • Author(s)
      Kohno M, Watanabe M, Izumi Y, Tasaka S, Kitagawa Y, Maruyama I, Kobayashi K
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60(2) Pages: 124-30

    • DOI

      10.1055/s-0030-1271011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims : A pilot study2012

    • Author(s)
      Oda Y, Maruyama I, Maekawa T, et al
    • Journal Title

      Resuscitation

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims2012

    • Author(s)
      Oda Y, Tsuruta R, Fujita M, Kaneda K, Kawamura Y, Izumi T, Kasaoka S, Maruyama I., Maekawa T
    • Journal Title

      A pilot study

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease2012

    • Author(s)
      Yoshifuku A, Oyama K, Ibusuki A, Kawasaki M, Sakanoue M, Matsushita S, Kawai K, Kawahara K, Maruyama I, Kanekura T
    • Journal Title

      Clin Exp Dermatol

      Volume: 37 Pages: 241-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Secondary prevention of stroke : Pleiotropic effects of optimal oral pharmacotherapy2012

    • Author(s)
      Kikuchi K, Kawahara K, Miura N, Ito T, Morimoto Y, Tancharoen S, Takeshige N, Uchikado H, Sakamoto R, Miyagi N, Kikuchi C, Iida N, Shiomi N, Kuramoto T, Hirohata M, Maruyama I, Morioka M, Tanaka E
    • Journal Title

      Exp Ther Med

      Volume: 4(1) Pages: 3-7

    • URL

      http://www.spandidos-publications.com/etm/

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine2012

    • Author(s)
      Kojima M, Maruyama I, Kitagawa Y, et al
    • Journal Title

      J Surg Res

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Increased plasma levels of high mobility group box 1 in patients with acute liver failure.2012

    • Author(s)
      Oshima G, Shinoda M, Tanabe M, Ebinuma H, Nishiyama R, Takano K, Yamada S, Miyasho T, Masugi Y, Matsuda S, Suda K, Fukunaga K, Matsubara K, Hibi T, Yagi H, Hayashida T, Yamagishi Y, Obara H, Itano O, Takeuchi H, Kawachi S, Saito H, Hibi T, Maruyama I, Kitagawa Y
    • Journal Title

      Eur Surg Res

      Volume: 48(3) Pages: 154-162

    • DOI

      10.1159/000338363

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591875, KAKENHI-PROJECT-23791498, KAKENHI-PROJECT-24591888
  • [Journal Article] MK615, a Prunus mume Steb. Et Zucc ('Ume') extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway.2012

    • Author(s)
      Tada K
    • Journal Title

      Phytother Res

      Volume: (in press) Pages: 833-8

    • DOI

      10.1002/ptr.3645

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591438, KAKENHI-PROJECT-22390179, KAKENHI-PROJECT-24659804
  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine.2012

    • Author(s)
      Kojima M, Tanabe M, Shinoda M, Yamada S, Miyasho T, Suda K, Hibi T, Obara H, Itano O, Kawachi S, Kitajima M, Maruyama I, Kitagawa Y
    • Journal Title

      J Surg Res.

      Volume: 178(1) Pages: 466-471

    • DOI

      10.1016/j.jss.2012.01.044

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23591875, KAKENHI-PROJECT-24591888, KAKENHI-PROJECT-24659798
  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine2012

    • Author(s)
      Kojima M, Maruyama I, Kitagawa Y, et al
    • Journal Title

      J Surg Res

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Granulocyte and monocyte adsorption apheresis as an effective treatment for Reiter disease2012

    • Author(s)
      Yoshifuku A, Oyama K, Ibusuki A, Kawasaki M, Sakanoue M, Matsushita S, Kawai K, Kawahara K, Maruyama I, Kanekura T
    • Journal Title

      Clin Exp Dermatol

      Volume: 37(3) Pages: 241-4

    • DOI

      10.1111/j.1365-2230.2011.04181.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2012

    • Author(s)
      Kohno M, Watanabe M, Izumi Y, Tasaka S, Kitagawa Y, Maruyama I, Kobayashi K.
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60(2) Pages: 124-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Paucity of CD34-positive cells and increased expression of high-mobility group box 1 in coronary thrombus with type 2 diabetes mellitus2012

    • Author(s)
      Yamashita A, Nishihira K, Matsuura Y, Ito T, Kawahara K, Hatakeyama K, Hashiguchi T, Maruyama I, Yagi H, Matsumoto M, Fujimura Y, Kitamura K, Shibata Y, Asada Y.
    • Journal Title

      Atherosclerosis

      Volume: 224(2) Pages: 511-514

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] Immunohistochemical expression of thrombomodulin in vestibular schwannoma2012

    • Author(s)
      Yamahata H, Yunoue S, Tokimura H, Hanaya R, Hirano H, Tokudome M, Karki P, Yonezawa H, Sugata S, Kawahara KI, Maruyama I, Arita K
    • Journal Title

      Brain Tumor Pathol

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] MK615, a Prunus mume Steb. Et Zucc ('Ume') extract, attenuates the growth of A375 melanoma cells by inhibiting the ERK1/2-Id-1 pathway2012

    • Author(s)
      Tada K, Kawahara K, Matsushita S, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Phytother Res

      Volume: 26(6) Pages: 833-838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims : A pilot study2012

    • Author(s)
      Oda Y Maruyama I, Maekawa T, et al
    • Journal Title

      Resuscitation

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Ishii J, Kitagawa F, Yamada S, Hattori K, Okumura M, Naruse H, Motoyama S, Matsui S, Tanaka I, Izawa H, Maruyama I, Nomura M, Ozaki Y.
    • Journal Title

      Atherosclerosis

      Volume: 221(2) Pages: 490-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Role of high mobility group box chromosomal protein 1 in ischemia-reperfusion injury in the rat small intestine2012

    • Author(s)
      Kojima M, Tanabe M, Shinoda M, Yamada S, Miyasho T, Suda K, Hibi T, Obara H, Itano O, Kawachi S, Kitajima M, Maruyama I, Kitagawa Y.
    • Journal Title

      J Surg Res

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Prediction of the neurological outcome with intrathecal high mobility group box 1 and S100B in cardiac arrest victims : a pilot study2012

    • Author(s)
      Oda Y, Tsuruta R, Fujita M, Kaneda K, Kawamura Y, Izumi T, Kasaoka S, Maruyama I, Maekawa T
    • Journal Title

      Resuscitation

      Volume: 83(8) Pages: 1006-12

    • DOI

      10.1016/j.resuscitation.2012.01.030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Circulating high-mobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction2012

    • Author(s)
      Hashimoto T, Maruyama I, Ozaki Y., et al
    • Journal Title

      Atherosclerosis

      Volume: 221 Pages: 490-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release o f high-mobility group box 12011

    • Author(s)
      Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K.
    • Journal Title

      Shock 2011

      Volume: 36(5) Pages: 494-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011

    • Author(s)
      Ito T, Maruyama I.
    • Journal Title

      J Thromb Haemost

      Volume: 9 Pages: 168-173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23890166
  • [Journal Article] 、Valproic acid increases susceptibility to endotoxin shock through enhanced release of HMGB1.2011

    • Author(s)
      Sugiura, et al
    • Journal Title

      Shock

      Volume: 36(5) Pages: 494-500

    • DOI

      10.1097/shk.0b013e31822f7e58

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J09815, KAKENHI-PROJECT-21659436, KAKENHI-PROJECT-22390354, KAKENHI-PROJECT-22592322, KAKENHI-PROJECT-23390412
  • [Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Maruyama I, Nukiwa T, et al
    • Journal Title

      Pulm Med

      Volume: 2011 Pages: 916486-916486

    • NAID

      120005761658

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2011

    • Author(s)
      Kohno M, Maruyama I, Kobayashi K., et al
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60 Pages: 124-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Quantitative peptidomic analysis by a newly developed one-step direct transfer technology without depletion of major blood proteins: its potential utility for monitoring of pathophysiological status in pregnancy-induced hypertension2011

    • Author(s)
      Araki Y, Nonaka D, Tajima A, Maruyama M, Nitto T, Ishikawa H, Yoshitake H, Yoshida E, Kuronaka N, Asada K, Yanagida M, Nojima M, Yoshida K, Takamori K, Hashiguchi T, Maruyama I, Lee LJ, Tanaka K
    • Journal Title

      Proteomics.

      Volume: 11(13) Pages: 2727-2737

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release of high-mobility group box 12011

    • Author(s)
      Sugiura S, Ishihara Y, Komatsu T, Hagiwara M, Tanigawa N, Kato Y, Mizutani H, Kawahara K, Maruyama I, Noguchi T, Matsushita K
    • Journal Title

      Shock

      Volume: 36 Pages: 494-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type1-associated neurological disease.2011

    • Author(s)
      Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T.
    • Journal Title

      Antiviral Therapy

      Volume: 24 Pages: 605-611

    • DOI

      10.3892/ijmm_00000271

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-23659176
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation. J2011

    • Author(s)
      Ito T, Maruyama I
    • Journal Title

      Thromb Haemost

      Volume: 9 Pages: 168-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011

    • Author(s)
      Takashi Ito & Ikuro Maruyama.
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: 9 Pages: 168-173

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] NSAIDs inhibit neovascularization of chroid through HO-1-dpendency pathway2011

    • Author(s)
      Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I
    • Journal Title

      Sakamoto T. Lab Invest

      Volume: 91 Pages: 1277-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] 新規DIC 治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      伊藤隆史, 丸山征郎
    • Journal Title

      臨床血液

      Volume: 52巻 Pages: 356-360

    • NAID

      130004501537

    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation J2011

    • Author(s)
      Ito T, Maruyama I
    • Journal Title

      Thromb Haemost

      Volume: 9 Pages: 168-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      伊藤隆史、丸山征郎
    • Journal Title

      臨床血液

      Volume: 52 Pages: 356-360

    • NAID

      130004501537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23890166
  • [Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      伊藤隆史・丸山征郎
    • Journal Title

      臨床血液

      Volume: 第52巻6号 Pages: 356-360

    • NAID

      130004501537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23890166
  • [Journal Article] Improvement of Blood Compatibility on Polysulfone-Polyvinylpyrrolidone Blend Films as a Model Membrane of Dialyzer by Physical Adsorption of Recombinant Soluble Human Thrombomodulin (ART-123).2011

    • Author(s)
      Omichi M, Matsusaki M, Maruyama I, Akashi M.
    • Journal Title

      J Biomater Sci Polym Ed.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659327
  • [Journal Article] NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway2011

    • Author(s)
      Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I, Sakamoto T.
    • Journal Title

      Lab Invest

      Volume: 91(9) Pages: 1277-1290

    • DOI

      10.1038/labinvest.2011.101

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450, KAKENHI-PROJECT-22390179
  • [Journal Article] NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway2011

    • Author(s)
      Yoshinaga N, Arimura N, Otsuka H, Kawahara K, Hashiguchi T, Maruyama I, Sakamoto T
    • Journal Title

      Lab Invest

      Volume: 91(9) Pages: 1277-1290

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] Gradualincrease of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Maruyama I, Nukiwa T, et al
    • Journal Title

      Pulm Med

      Volume: 2011 Pages: 916486-916486

    • NAID

      120005761658

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Improvement of Blood Compatibility on Polysulfone-Polyvinylpyrrolidone Blend Films as a Model Membrane of Dialyzer by Physical Adsorption of Recombinant Soluble Human Thrombomodulin(ART-123).2011

    • Author(s)
      Omichi M, Matsusaki M, Maruyama I, Akashi M.
    • Journal Title

      J Biomater Sci Polym Ed.

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Ohkouchi S, Tamada T, Nishimura H, Ishizaka A, Maruyama I, Okada Y, Takashi K, Nukiwa T.
    • Journal Title

      Pulm Med

      Volume: 2011 Pages: 916486-916486

    • NAID

      120005761658

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Valproic acid increases susceptibility to endotoxin shock through enhanced release o f high-mobility group box 12011

    • Author(s)
      Sugiura S, Maruyama I, Matsushita K., et al
    • Journal Title

      Shock

      Volume: 36(5) Pages: 494-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Journal Article] Thrombomodulin : protectorate God of the vasculature in thrombosis and inflammation2011

    • Author(s)
      Ito T, Maruyama I.
    • Journal Title

      J Thromb Haemost

      Volume: 1 Pages: 168-73

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      伊藤隆史、丸山征郎
    • Journal Title

      臨床血液

      Volume: 52 Pages: 356-360

    • NAID

      130004501537

    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Gradual increase of high mobility group protein b1 in the lungs after the onset of acute exacerbation of idiopathic pulmonary fibrosis2011

    • Author(s)
      Ebina M, Taniguchi H, Miyasho T, Yamada S, Shibata N, Ohta H, Hisata S, Hirota N, Nishimura H, Ishizaka A, Maruyama I, Takashi K, Nukiwa T
    • Journal Title

      Pulm Med

      Volume: 916486 Pages: 1-9

    • DOI

      10.1155/2011/916486

    • NAID

      120003072907

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390164, KAKENHI-PROJECT-23390412
  • [Journal Article] Valproic acid increases susceptibilty to endotoxin shock through enhanced release of high-mobility group box 12011

    • Author(s)
      Sugiura S, Maruyama I, Matsushita K, et al
    • Journal Title

      Shock

      Volume: 36(5) Pages: 494-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] 新規DIC治療薬トロンボモジュリン製剤の作用機序2011

    • Author(s)
      Ito T, Maruyama I
    • Journal Title

      Journal of Thrombosis and Haemostasis

      Volume: Suppl 1 Pages: 168-173

    • DOI

      10.1111/j.1538-7836.2011.04319.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390412, KAKENHI-PROJECT-23890166
  • [Journal Article] Mitigation of occult lung injury by pneumonectomy via minithoracotomy in mice2011

    • Author(s)
      Kohno M, Maruyama I, Kobayashi K, et al
    • Journal Title

      Thorac Cardiovasc Surg

      Volume: 60 Pages: 124-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659491
  • [Journal Article] Neutrophil elastase inhibitor improves survival of rats with clinically relevant sepsis.2010

    • Author(s)
      Suda K, Takeuchi H, Hagiwara T, Miyasho T, Okamoto M, Kawasako K, Yamada S, Suganuma K, Wada N, Saikawa Y, Fukunaga K, Funakoshi Y, Hashimoto S, Yokota H, Maruyama I, Ishizaka A, Kitagawa Y.
    • Journal Title

      Shock. 33(5)

      Pages: 526-531

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.2010

    • Author(s)
      Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T.
    • Journal Title

      Am J Pathol. 177(5)

      Pages: 2268-2277

    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Protective effect of high-mobility group box 1 blockade on acute liver failure in rats.2010

    • Author(s)
      Takano K, Maruyama I, Kitagawa Y., et al.
    • Journal Title

      Shock 34(6)

      Pages: 573-579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis.2010

    • Author(s)
      Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I, Komiya S.
    • Journal Title

      Spine (Phila Pa 1976). 35(11)

      Pages: 1109-1115

    • NAID

      10027252218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] B cell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes.2010

    • Author(s)
      Hashiguchi T*, Shrestha B*, Ito T*, Miura N* (*Equal contribution), Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-i Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I
    • Journal Title

      J Immunol 184

      Pages: 4819-4826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] High mobility group box 1 is upregulated after spinal cord injury and is associated with neuronal cell apoptosis2010

    • Author(s)
      Kawabata H, Setoguchi T, Yone K, Souda M, Yoshida H, Kawahara K, Maruyama I, Komiya S
    • Journal Title

      Spine(Phila Pa 1976)

      Volume: 35 Pages: 1109-15

    • NAID

      10027252218

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB2010

    • Author(s)
      Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 397 Pages: 350-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Hemoperfusion with a high-mobility group box 1 adsorption column can prevent the occurrence of hepatic ischemia-reperfusion injury in rats.2010

    • Author(s)
      Yamamoto T, Ono T, Ito T, Yamanoi A, Maruyama I, Tanaka T.
    • Journal Title

      Crit Care Med. 38(3)

      Pages: 879-885

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] The diagnostic value of endothelial function as a potential sensor of fatigue in health.2010

    • Author(s)
      Ohno Y, Hashiguchi T, Maenosono R, Yamashita H, Taira Y, Minowa K, Yamashita Y, Kato Y, Kawahara K, Maruyama I
    • Journal Title

      Vasc Health Risk Manag 6

      Pages: 135-144

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment2010

    • Author(s)
      Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T
    • Journal Title

      Am J Pathol

      Volume: 177 (5) Pages: 2268-2277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice.2010

    • Author(s)
      Matsuoka N, Itoh T, Watarai H, Sekine-Kondo E, Nagata N, Okamoto K, Mera T, Yamamoto H, Yamada S, Maruyama I, Taniguchi M, Yasunami Y.
    • Journal Title

      J Clin Invest. 120(3)

      Pages: 735-743

    • NAID

      120002142757

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Hyperglycemia enhances excessive superoxide anion radical generation, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats.2010

    • Author(s)
      Tsuruta R, Fujita M, Ono T, Koda Y, Koga Y, Yamamoto T, Nanba M, Shitara M, Kasaoka S, Maruyama I, Yuasa M, Maekawa T.
    • Journal Title

      Brain Res. 1309

      Pages: 155-163

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Spherical sulfated cellulose adsorbs high-mobility-group box chromosomal protein 1 in vitro and in vivo.2010

    • Author(s)
      Suda K, Takeuchi H, Maruyama I, Kitagawa Y, et al.
    • Journal Title

      ASAIO J.

      Volume: 56(3) Pages: 210-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659327
  • [Journal Article] High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy2010

    • Author(s)
      Oyama Y, Hashiguchi T, Taniguchi N, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda T, Umekita Y, Lotz M, Maruyama I
    • Journal Title

      Lab Invest

      Volume: 90 Pages: 853-66

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Advanced malignant melanoma responds to Prunus mume Sieb. Et Zucc (Ume) extract: Case report and in vitro study.2010

    • Author(s)
      Matsushita S, Tada KI, Kawahara KI, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Exp Ther Med

      Volume: 1(4) Pages: 569-574

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy.2010

    • Author(s)
      Oyama Y, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Lab Invest. 90(6)

      Pages: 853-866

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Involvement of the endocannabinoid system in periodontal healing2010

    • Author(s)
      Kozono S, Matsuyama T, Biwasa KK, Kawahara K, Nakajima Y, Yoshimoto T, Yonamine Y, Kadomatsu H, Tancharoen S, Hashiguchi T, Noguchi K, Maruyama I
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 394 Pages: 928-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Spherical sulfated cellulose adsorbs high-mobility-group box chromosomal protein 1 in vitro and in vivo.2010

    • Author(s)
      Suda K, Takeuchi H, Maruyama I, Kitagawa Y, et al.
    • Journal Title

      ASAIO J. 56(3)

      Pages: 210-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment.2010

    • Author(s)
      Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafbzi-Moghadam A, Sakamoto T.
    • Journal Title

      Am J Pathol.

      Volume: 177(5) Pages: 2268-2277

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Spherical sulfated cellulose adsorbs high-mobility-group box chromosomal protein 1 in vitro and in vivo.2010

    • Author(s)
      Suda K, Takeuchi H, Maruyama I, Kitagawa Y, et al.
    • Journal Title

      ASAIO J.

      Volume: 56(3) Pages: 210-214

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] The diagnostic value of endothelial function as a potential sensor of fatigue in health2010

    • Author(s)
      Ohno Y, Hashiguchi T, Maenosono R, Yamashita H, Taira Y, Minowa K, Yamashita Y, Kato Y, Kawahara K, Maruyama I
    • Journal Title

      Vasc Health Risk Manag

      Volume: 24 Pages: 135-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVB2010

    • Author(s)
      Mera K, Kawahara K, Tada K, Kawai K, Hashiguchi T, Maruyama I, Kanekura T
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 397(2) Pages: 350-354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Journal Article] Protective effect of high mobility group box 1 blockade on acute liver failure in rats.2010

    • Author(s)
      Takano K, Maruyama I, Kitagawa Y, et al.
    • Journal Title

      Shock

      Volume: 34(6) Pages: 573-579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] B Cell-Derived Vascular Endothelial Growth Factor A Promotes Lymphangiogenesis and High Endothelial Venule Expansion in Lymph Nodes2010

    • Author(s)
      Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I
    • Journal Title

      J Immunol

      Volume: 184 Pages: 4819-26

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Bcell-derived vascular endothelial growth factor A promotes lymphangiogenesis and high endothelial venule expansion in lymph nodes.2010

    • Author(s)
      Shrestha B, Hashiguchi T, Ito T, Miura N, Takenouchi K, Oyama Y, Kawahara K, Tancharoen S, Ki-I Y, Arimura N, Yoshinaga N, Noma S, Shrestha C, Nitanda T, Kitajima S, Arimura K, Sato M, Sakamoto T, Maruyama I.
    • Journal Title

      J Immunol.

      Volume: 184(9) Pages: 4819-4826

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Protective effect of high-mobility group box 1 blockade on acute liver failure in rats.2010

    • Author(s)
      Takano K, Maruyama I, Kitagawa Y., et al.
    • Journal Title

      Shock

      Volume: 34(6) Pages: 573-579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659327
  • [Journal Article] Edaravone : a new therapeutic approach for the treatment of acute stroke2010

    • Author(s)
      Kikuchi K, Kawahara K, Miyagi N, Uchikado H, Kuramoto T, Morimoto Y, Tancharoen S, Miura N, Takenouchi K, Oyama Y, Shrestha B, Matsuda F, Yoshida Y, Arimura S, Mera K, Tada K, Yoshinaga N, Maenosono R, Ohno Y, Hashiguchi T, Maruyama I, Shigemori M
    • Journal Title

      Med Hypotheses

      Volume: 75 Pages: 583-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy2010

    • Author(s)
      Oyama Y, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Lab Invest (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Green tea extract supplement inhibition of HMGB1 release in rats exposed to cigarette smoke2010

    • Author(s)
      Saiwichai T, Sangalangkarn V, Kawahara K, Oyama Y, Chaichalotornkul S, Narkpinit S, Harnyuttanakorn P, Singhasivanon P, Maruyama I, Tancharoen S
    • Journal Title

      Southeast Asian J Trop Med Public Health

      Volume: 41 Pages: 250-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] 1, 5-Anhydroglucitol attenuates cytokine release and protects mice with type 2 diabetes from inflammatory reactions2010

    • Author(s)
      Meng X, Tancharoen S, Kawahara KI, Nawa Y, Taniguchi S, Hashiguchi T, Maruyama I
    • Journal Title

      Int J Immunopathol Pharmacol

      Volume: 23 Pages: 105-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Hyperoxia suppresses excessive superoxide anion radical generation in blood, oxidative stress, early inflammation, and endothelial injury in forebrain ischemia/reperfusion rats : laboratory study.2010

    • Author(s)
      Fujita M, Tsuruta R, Kaneko T, Otsuka Y, Kutsuna S, Izumi T, Aoki T, Shitara M, Kasaoka S, Maruyama I, Yuasa M, Maekawa T.
    • Journal Title

      Shock. 34(3)

      Pages: 299-305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Stromal cell-derived factor-1 is essential for photoreceptor cell protection in retinal detachment2010

    • Author(s)
      Otsuka H, Arimura N, Sonoda S, Nakamura M, Hashiguchi T, Maruyama I, Nakao S, Hafezi-Moghadam A, Sakamoto T.
    • Journal Title

      Am J Pathol

      Volume: 177(5) Pages: 2268-2277

    • DOI

      10.2353/ajpath.2010.100134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGB1induced cell death in ischemic neuronal injury in PC12 cells.-2009

    • Author(s)
      Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Biochem Biophys Res Commun. 385(2)

      Pages: 132-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Nucleophosmin may act as an alarmin : implications for severe sepsis2009

    • Author(s)
      Nawa Y, Kawahara K, Tancharoen S, Meng X, Sameshima H, Ito T, Masuda Y, Imaizumi H, Hashiguchi T, Maruyama I
    • Journal Title

      J Leukoc Biol

      Volume: 86 Pages: 645-53

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Diagnostic value of serum peptidome analyses for protease activated pathological conditions beyond cancer diagnosis.2009

    • Author(s)
      Hashiguchi T, Tanaka K, Lee LJ, Sasaki K, Natsugoe S, Kawahara K, Arimura K, Maruyama I
    • Journal Title

      Med Hypotheses 73

      Pages: 760-763

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment2009

    • Author(s)
      Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
    • Journal Title

      Lab Invest 89(3)

      Pages: 278-289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells2009

    • Author(s)
      Kikuchi K, Kawahara K, Tancharoen S, Matsuda F, Morimoto Y, Ito T, Biswas KK, Takenouchi K, Miura N, Oyama Y, Nawa Y, Arimura N, Iwata M, Tajima Y, Kuramoto T, Nakayama K, Shigemori M, Yoshida Y, Hashiguchi T, Maruyama I
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 329 Pages: 865-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment.2009

    • Author(s)
      Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I
    • Journal Title

      Lab Invest 89

      Pages: 278-289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] An elevated value of high mobility group box 1 is a potential marker for poor response to high-dose of intravenous immunoglobulin treatment in patients with Kawasaki syndrome.2009

    • Author(s)
      Eguchi T, Nomura Y, Hashiguchi T, Masuda K, Arata M, Hazeki D, Ueno K, Nishi J, Kawano Y, Maruyama I.
    • Journal Title

      Pediatr Infect Dis J. 28(4)

      Pages: 339-341

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] High-mobility group box 1 protein in CSF of patients with subarachnoid hemorrhage.2009

    • Author(s)
      Nakahara T, Tsuruta R, Kaneko T, Yamashita S, Fujita M, Kasaoka S, Hashiguchi T, Suzuki M, Maruyama I, Maekawa T.
    • Journal Title

      Neurocrit Care. 11(3)

      Pages: 362-368

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha2009

    • Author(s)
      Izumi T, Fujii R, Izumi T, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S, Nakajima T
    • Journal Title

      Arthritis Rheum

      Volume: 60 Pages: 63-72

    • DOI

      10.1002/art.24178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052
  • [Journal Article] Vitreous mediators after intravitreal bevacizumab or triamcinolone acetonide in eyes with proliferative diabetic retinopathy.2009

    • Author(s)
      Arimura N, Otsuka H, Yamakiri K, Sonoda Y, Nakao S, Noda Y, Hashiguchi T, Maruyama I, Sakamoto T
    • Journal Title

      Ophthalmology 116

      Pages: 921-926

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] Increased Prevalence of Group A b-hemolytic Streptococcus Among Ethnic Population in Kyrgyzstan Defined by Rapid Antigen Detection Test2009

    • Author(s)
      中島利博、八木下尚子、上昌広、丸山征郎、山野嘉久, 他12名
    • Journal Title

      Molecular Medicine Reports 1(6)

      Pages: 869-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052
  • [Journal Article] Increased Prevalence of Group A b-hemolnytic Streptococcus Among Ethnic Population in Kyrgyzstan Defined by Rapid Antigen Detection Test.2009

    • Author(s)
      中島利博、八木下尚子、丸山征郎、山野嘉久他13名
    • Journal Title

      Molecular Medicine Reports 1(6)

      Pages: 869-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20059033
  • [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment2009

    • Author(s)
      Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
    • Journal Title

      Lab Invest

      Volume: 89(3) Pages: 278-289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Xanthine oxidase is one of the major sources of superoxide anion radicals in blood after reperfusion in rats with forebrain ischemia/reperfusion.2009

    • Author(s)
      Ono T, Tsuruta R, Fujita M, Aki HS, Kutsuna S, Kawamura Y, Wakatsuki J, Aoki T, Kobayashi C, Kasaoka S, Maruyama I, Yuasa M, Maekawa T.
    • Journal Title

      Brain Res. 1305

      Pages: 158-167

    • NAID

      120002220601

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Role of Kenae/CCDC125 in cell motility through the deregulation of RhoGTPase2009

    • Author(s)
      Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T
    • Journal Title

      Int J Mol Med

      Volume: 24 Pages: 605-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Mechanism of HMGB1 release inhibition from RAW264.7 cells by oleanolic acid in Prunus mume Sieb. et Zucc2009

    • Author(s)
      Kawahara K, Hashiguchi T, Masuda K, Saniabadi AR, Kikuchi K, Tancharoen S, Ito T, Miura N, Morimoto Y, Biswas KK, Nawa Y, Meng X, Oyama Y, Takenouchi K, Shrestha B, Sameshima H, Shimizu T, Adachi T, Adachi M, Maruyama I
    • Journal Title

      Int J Mol Med

      Volume: 23 Pages: 615-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells.2009

    • Author(s)
      Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      J Pharmacol Exp Ther. 329(3)

      Pages: 865-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha.2009

    • Author(s)
      Izumi T, Fujii R, Izumi T, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S, Nakajima T
    • Journal Title

      Arthritis Rheum. 60(1)

      Pages: 63-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052
  • [Journal Article] Vitreous mediators after intravitreal bevacizumab or triamcinolone acetonide in eyes with proliferative diabetic retinopathy2009

    • Author(s)
      Arimura N, Ohtsuka H, Yamakiri K, Sonoda Y, Nakao S, Noda Y, Hashiguchi T, Maruyama I, Sakamoto T.
    • Journal Title

      Ophthalmology 116(5)

      Pages: 921-926

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment.2009

    • Author(s)
      Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I
    • Journal Title

      Lab Invest. 89(3)

      Pages: 278-289

    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] MK615 attenuates Porphyromonas gingivalis lipopolysaccharide-induced pro-inflammatory cytokine release via MAPK inactivation in murine macrophage-like RAW264.7 cells2009

    • Author(s)
      Morimoto Y, Kikuchi K, Ito T, Tokuda M, Matsuyama T, Noma S, Hashiguchi T, Torii M, Maruyama I, Kawahara K
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 389 Pages: 90-94

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Attenuation of LPS-induced iNOS expression by 1, 5-anhydro-d-fructose2009

    • Author(s)
      Meng X, Kawahara K, Matsushita K, Nawa Y, Shrestha B, Kikuchi K, Sameshima H, Hashiguchi T, Maruyama I
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 387 Pages: 42-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390483
  • [Journal Article] Minocycline attenuates both OGD-induced HMGB1 release and HMGBlinduced cell death in ischemic neuronal injury in PC12 cells.2009

    • Author(s)
      Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Biochem Biophys Res Commun. 385(2)

      Pages: 132-136

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] The free radical scavenger edaravone rescues rats from cerebral infarction by attenuating the release of high-mobility group box-1 in neuronal cells2009

    • Author(s)
      Kikuchi K, Kawahara K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      J Pharmacol Exp Ther. 329(3)

      Pages: 865-74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Intraocular expression and release of high-mobility group box 1 protein in retinal detachment.2009

    • Author(s)
      Arimura N, Ki-i Y, Hashiguchi T, Kawahara K, Biswas KK, Nakamura M, Sonoda Y, Yamakiri K, Okubo A, Sakamoto T, Maruyama I.
    • Journal Title

      Lab Invest. 89(3)

      Pages: 278-289

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] Increased Prevalence of Group A b-hemolytic Streptococcus Among Ethnic Population in Kyrgyzstan Defined by Rapid Antigen Detection Test.2009

    • Author(s)
      中島利博、八木下尚子、丸山征郎、山野嘉久他13名
    • Journal Title

      Molecular Medicine Reports 1(6)

      Pages: 869-874

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013045
  • [Journal Article] Elevation of jugular venous superoxide anion radical is associated with early inflammation, oxidative stress, and endothelial injury in forebrain ischemia-reperfusion rats.2009

    • Author(s)
      Aki HS, Fujita M, Yamashita S, Fujimoto K, Kumagai K, Tsuruta R, Kasaoka S, Aoki T, Nanba M, Murata H, Yuasa M, Maruyama I, Maekawa T.
    • Journal Title

      Brain Res. 1292

      Pages: 180-190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] The effect of chemical and/or mechanical conditioning on the Er : YAG laser treated root cementum : analysis of surface morphology and periodontal ligament fibroblast attachment2008

    • Author(s)
      Maruyama H, Aoki A, Sasaki KM, Takasaki AA, Iwasaki K, Ichinose S, Oda S, Ishikawa I, Izumi Y.
    • Journal Title

      Lasers Surg Med 40(3)

      Pages: 211-222

    • Data Source
      KAKENHI-PROJECT-18390561
  • [Journal Article] High mobility group box chromosomal protein 1 in patients with renal diseases.2008

    • Author(s)
      Sato F, Maruyama S, Hayashi H, Uchimura T, et. al.
    • Journal Title

      Nephron Clin Pract 108

      Pages: 194-201

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19590564
  • [Journal Article] Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.2008

    • Author(s)
      Ito T, Kawahara K, Maruyama I, and, et al.
    • Journal Title

      Arterioscler Thromb Vase Biol. 28(10)

      Pages: 1825-30

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.2008

    • Author(s)
      Kawahara K, Hashiguchi T, Maruyama I, and, et al.
    • Journal Title

      Int J Mol Med. 22(5)

      Pages: 639-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.2008

    • Author(s)
      Ito T, Kawahara K, Maruyama I, et al.
    • Journal Title

      Biochem Biophys Res Commun. 377(2)

      Pages: 642-647

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Proteolytic cleavage of high mobility group box 1 protein by thrombin-thrombomodulin complexes.2008

    • Author(s)
      Ito T, Kawahara K, Maruyama I, et al.
    • Journal Title

      Arterioscler Thromb Vasc Biol. 28(10)

      Pages: 1825-1830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] Extracellular high mobility group box chromosomal protein 1 is a coupling factor for hypoxia and inflammation in arthritis2008

    • Author(s)
      Hamada T, Torikai M, Kuwazuru A, Tanaka M, Horai N, Fukuda T, Yamada S, Nagayama S, Hashiguchi K, Sunahara N, Fukuzaki K, Nagata R, Komiya S, Maruyama I, Fukuda T, Abeyama K
    • Journal Title

      Arthritis Rheum(IF : 7.677) 58(9)

      Pages: 2675-2685

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] The role of water channel aquaporin 3 in the mechanism of TNF alpha-mediated proinflammatory events2008

    • Author(s)
      Tancharoen S, Matsuyama T, Abeyama K, Matsushita K. Kawahara K , Sangalungkarm V, Tokuda M, Hashiguchi T, Maruyama I, Izumi Y
    • Journal Title

      Implication in periodontal inflammation(IF : 3.643) 217(2)

      Pages: 338-349

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] Novel transcriptional complex of ILF3-GABP α activates synoviolin promoter in rheumatoid synovial cells2008

    • Author(s)
      中島利博、八木下尚子、山野嘉久、丸山征郎他19名
    • Journal Title

      A&R 60

      Pages: 63-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20013045
  • [Journal Article] High-mobility group box 1 protein in endophthalmitis.2008

    • Author(s)
      Arimura N, Ki-I Y, Hashiguchi T, Sakamoto T, Maruyama I
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 24

      Pages: 1053-1058

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] Increased prevalence of group Aβ-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection test2008

    • Author(s)
      Omurzakova OA, Yamano Y, Sato T, Izumi T, Azakami K, Hasegawa D, Fujii R, Yagishita N, Aratani S, Kabaeva ZS, Mirrakhimov MM, Kami M, Maruyama I, Osame M, Yokota S, Nishioka K, Nakajima T
    • Journal Title

      Molecular Medicine Reports

      Volume: 1 Pages: 869-874

    • DOI

      10.3892/mmr_00000043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052
  • [Journal Article] Tumor necrosisi factor-alpha stimulates gingival epithelial cells to release high mobility-group box 12008

    • Author(s)
      Morimoto, Y., Kawahara, K-I., Tancharoen, S., Kikuchi, K., Matsuyama, T., Hashiguchi, T., Izumi, Y., Maruyama, I.
    • Journal Title

      J Periodontal Res. 43

      Pages: 76-83

    • Data Source
      KAKENHI-PROJECT-18390561
  • [Journal Article] Novel transcriptional complex of ILF3-GABP α activates synoviolin promoter in rheumatoid synovial cells2008

    • Author(s)
      中島利博、八木下尚子、山野嘉久、丸山征郎, 他19名
    • Journal Title

      A&R 60

      Pages: 63-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052
  • [Journal Article] A novel function of the receptor for advanced glycation end products (RAGE) in association with tumorigenesis and tumor differentiation of HCC2008

    • Author(s)
      Hiwatashi K, Ueno S, Abeyama K, Kubo F, Sakoda M, Maruyama I, Hamanoue M, Natsugoe S, Aikou T
    • Journal Title

      Ann Surg Oncol(IF : 3.917) 15(3)

      Pages: 923-933

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] The role of water channel aquaporin 3 in the mechanism of TNF-alpha-mediated proinflammatory events : Implication in periodontal inflammation2008

    • Author(s)
      S. Tancharoen, T. Matsuyama, K. Abeyama, K. Matsushita, K. Kawahara, V. Sangalungkarn, M. Tokuda, T. Hashiguchi, I. Maruyama, Y. Izumi
    • Journal Title

      J Cell Physiol 217

      Pages: 338-349

    • Data Source
      KAKENHI-PROJECT-18390561
  • [Journal Article] Novel transcriptional complex of ILF3-GABP α activates synoviolin promoter in rheumatoid synovial cells2008

    • Author(s)
      中島利博、八木下尚子、山野嘉久、丸山征郎他19名
    • Journal Title

      A&R 60

      Pages: 63-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20059033
  • [Journal Article] Induction of high mobility group box 1 release from serotonin-stimulated human umbilical vein endothelial cells.2008

    • Author(s)
      Kawahara K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Int J Mol Med. 22(5)

      Pages: 639-644

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Journal Article] High mobility group box chromosomal protein 1 in patients with renal diseases2008

    • Author(s)
      Sato F, Maruyama S, Hayashi H, Uchimura T et.al.
    • Journal Title

      Nephron Clin Pract 108

      Pages: 194-201

    • Data Source
      KAKENHI-PROJECT-19590564
  • [Journal Article] C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.2007

    • Author(s)
      Kawahara K, Biswas KK, Maruyama I, et. al.
    • Journal Title

      Cardiovasc Pathol. 17(3)

      Pages: 129-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Serum VEGF-as a prognostic factor of atherosclerosis.2007

    • Author(s)
      Kimura K, Hashiguchi T, Deguchi T, Horinouchi S, Uto T, Oku H, Setoyama S, Maruyama I, Osame M, Arimura K
    • Journal Title

      Atherosclerosis 194

      Pages: 182-188

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] HMGB1 release in co-cultures of porcine endothelial and human T cells2007

    • Author(s)
      Kawahara K, Setoyama K, Maruyama I and, et. al.
    • Journal Title

      Xenotransplantation. 14(6)

      Pages: 636-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659470
  • [Journal Article] Physical Adsorption of Human Thrombomodulin (ART -123) onto Polymeric Biomaterials for Developing an Antithrombogenic Blood-Contacting Material2007

    • Author(s)
      M.Matsusaki, M.Omichi, I.Maruyama, M.Akashi
    • Journal Title

      J. Biomed. Mater. Res. (in press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Journal Article] HMGB1 expression by activated vascular smooth muscle cells in advanced human atherosclerosis plaques.2007

    • Author(s)
      Inoue K, Kawahara K, Maruyama I and, et. al.
    • Journal Title

      Cardiovasc Pathol. 16(3)

      Pages: 136-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] HMGB1 release in co-cultures of porcine endothelial and human T cells.2007

    • Author(s)
      Kawahara K, Takao S, Maruyama I.
    • Journal Title

      Xenotransplantation 14

      Pages: 636-641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17100007
  • [Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats2007

    • Author(s)
      Ito T, Kawahara K, Nakamura T, Yamada S, Nakamura T, Abeyama K, Hashiguchi T, Maruyama I
    • Journal Title

      J Thromb Haemost(IF : 5.947) 5(1)

      Pages: 109-1116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.2007

    • Author(s)
      Yamasaki S, Yagishita N, Sasaki T, Nakazawa M, Kato Y, Yamadera T, Bae E, Toriyama S, Ikeda R, Zhang L, Fujitani K, Yoo E, Tsuchimochi K, Ohta T, Araya N, Fujita H, Aratani S, Eguchi K, Komiya S, Maruyama I, Higashi N, Sato M, Senoo H, Ochi T, Yokoyama S, Amano T, Kim J, Gay S, Fukamizu A, Nishioka K, Tanaka K, Nakajima T
    • Journal Title

      EMBO J 26(1)

      Pages: 113-22

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052
  • [Journal Article] HMGB1 release in co-cultures of porcine endothelial and human T cells2007

    • Author(s)
      Kawahara K, Setoyama K, Maruyama I and, et. al.
    • Journal Title

      Xenotransplantation. 14(6)

      Pages: 636-41

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] C-reactive protein induces high-mobility group box-1 protein release through activation of p38MAPK in macrophage RAW264.7 cells.2007

    • Author(s)
      Kawahara K, Biswas KK, Maruyama I, et. al.
    • Journal Title

      Cardiovasc Pathol. 17(3)

      Pages: 129-38

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659470
  • [Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats.2007

    • Author(s)
      Ito T, Maruyama I, et al.
    • Journal Title

      J Thromb Haemost. 5(1)

      Pages: 109-116

    • Data Source
      KAKENHI-PROJECT-17659294
  • [Journal Article] HMGB1 expression by activated vascular smooth muscle cells in advanced human atherosclerosis plaques.2007

    • Author(s)
      Inoue K, Kawahara K, Maruyama I and, et. al.
    • Journal Title

      Cardiovasc Pathol. 16(3)

      Pages: 136-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19659470
  • [Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats2007

    • Author(s)
      Ito T, Maruyama I, et. al.
    • Journal Title

      J Thromb Haemost 5(1)

      Pages: 109-16

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] High-mobility group box 1 protein promotes development of microvascular thrombosis in rats.2007

    • Author(s)
      Ito T, Maruyama I, et al.
    • Journal Title

      J Thromb Haemost. 5(1)

      Pages: 109-16

    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Stromal-derived factor-1 and inflammatory cytokines in retinal vein occlusion.2007

    • Author(s)
      Ki-I Y, Arimura N, Noda Y, Yamakiri K, Doi N, Hashiguchi T, Maruyama I, Shimura M, Sakamoto T
    • Journal Title

      Curr Eye Res 32

      Pages: 1065-1072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification2007

    • Author(s)
      Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H
    • Journal Title

      Mol Cell Biol(IF : 6.42) 27(16)

      Pages: 5650-5663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] High-mobility group box ; protein promotes development of microvascula thrombosis in rats2007

    • Author(s)
      Ito, T., Maruyama, I., et. al.
    • Journal Title

      J Thromb Haemost(peer reviewed) 5(1)

      Pages: 109-16

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition.2006

    • Author(s)
      Nakajima Y, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 613-619

    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition2006

    • Author(s)
      Nakajima Y, Furuichi Y, Biswas KK, Hashiguchi T, Kawahara K, Yamaji K, .Uchimura T, Izumi Y, Maruyama I.
    • Journal Title

      FEBS Letter. 580(2)

      Pages: 613-9

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kB pathway inhibition2006

    • Author(s)
      Yumiko Nakajima, Yasushi Furuichi, Kamal Krishna Biswas, Teruto Hashiguchi, Ko-ichi Kawahara, Kazuyo Yamaji, Tomonori Uchimura, Yuichi Izumi, Ikuro Maruyama
    • Journal Title

      FEBS Letters 580

      Pages: 613-619

    • Data Source
      KAKENHI-PROJECT-18390561
  • [Journal Article] Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.2006

    • Author(s)
      Biswas KK, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      FEBS Letters 580・2

      Pages: 703-710

    • Data Source
      KAKENHI-PROJECT-17659294
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition2006

    • Author(s)
      Nakajima, Y., Furuichi, Y., Biswas, KK., Hashiguchi, T., Kawahara, K., Yamaji, K., Uchimura, T., Izumi, Y., Maruyama, I
    • Journal Title

      FEBS Lett 23, 580(2)

      Pages: 613-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] 炎症隔離分子としてのトロンボモジュリン2006

    • Author(s)
      阿辺山和浩、吉元 寧、丸山征郎
    • Journal Title

      血管医学((特集 : 血管炎のオムニバス)) vol. 7.No.3

      Pages: 19-25

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] 炎症隔離分子としてのトロンボモジュリン2006

    • Author(s)
      阿辺山 和浩、丸山 征郎
    • Journal Title

      血管医学(メディカルレビュー社) 7(3)

      Pages: 19-25

    • Data Source
      KAKENHI-PROJECT-18390481
  • [Journal Article] Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line(HuH-7)through the activation of JNK1/2 and the downxegulation of Akt2006

    • Author(s)
      BisNas KK, Hashiguchi T, Maruyama I, et. al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 703-10

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line(HuH-7)through the activation of JNK1/2 and the downregulation of Akt2006

    • Author(s)
      Biswas KK, Hashiguchi T, Maruyama I, et. al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 703-10

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.2006

    • Author(s)
      Biswas KK, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 703-710

    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition.2006

    • Author(s)
      Nakajima Y, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 613-619

    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition2006

    • Author(s)
      Nakajima, Y., Hashiguchi, T., Maruyama, I., et. al.
    • Journal Title

      FEBS Letters(peer reviewed) 580(2)

      Pages: 613-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Endocannabinoid,anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition2006

    • Author(s)
      Nakajima Y, Hashiguchi T, Maruyama I, et. al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 613-9

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB inhibition.2006

    • Author(s)
      Nakajima Y, Furuichi Y, Biswas KK, Hashiguchi T, Kawahara K, Yamaji K, Uchimura T, Izumi Y, Maruyama I
    • Journal Title

      FEBS Letter. 580(2)

      Pages: 613-9

    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Endocannabinoid, anandamide in gingival tissue regulates the periodontal inflammation through NF-kappaB pathway inhibition.2006

    • Author(s)
      Nakajima Y, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      FEBS Letters 580・2

      Pages: 613-619

    • Data Source
      KAKENHI-PROJECT-17659294
  • [Journal Article] Cepharanthine triggers apoptosis in a human hepatocellular carcinoma cell line (HuH-7) through the activation of JNK1/2 and the downregulation of Akt.2006

    • Author(s)
      Biswas KK, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      FEBS Letters 580(2)

      Pages: 703-710

    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] 腎疾患患者におけるHMGB1の意義に関する検討2005

    • Author(s)
      佐藤文彦, 丸山彰一, 三木祐介, 倉田圭, 森田良樹, 湯澤由紀夫, 内村友則, 丸山征朗, 松尾清一
    • Journal Title

      日本腎臓学会誌 47巻3号

      Pages: 287-287

    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.2005

    • Author(s)
      Yamaji K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Thrombosis Research 115・4

      Pages: 319-325

    • Data Source
      KAKENHI-PROJECT-17659294
  • [Journal Article] HMGB1 contributes to the development of acute lung injury after hemorrhage.2005

    • Author(s)
      Kim JY, Maruyama I, Ishizaka A, Abraham E.et al.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol. 288・(5)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.2005

    • Author(s)
      Abeyama K, Stern DM, Ito Y, Kawahara KI, Yoshimoto Y, Tanaka M, Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto H, Iino S, Taniguchi N, Maruyama I.
    • Journal Title

      J Clin Invest. 115(5)

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban.2005

    • Author(s)
      Sarker KP, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Pathophysiology of Haemostasis and Thrombosis 34(1)

      Pages: 41-47

    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by diminishing oxidative stress in a rat model of hepatocellular carcinoma2005

    • Author(s)
      Ueno S, Aoki D, Kubo F, Hiwatashi K, Matsushita K, Oyama T, Maruyama I, Aikou T.
    • Journal Title

      Clin Cancer Res. 11(15)

      Pages: 5645-5650

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370359
  • [Journal Article] HMGB1 contributes to the development of acute lung injury after hemorrhage.2005

    • Author(s)
      Kim JY, Park JS, Strassheim D, Douglas I, Diaz del Valle F, Asehnoune K, Mitra S, Kwak SH, Yamada S, Maruyama I, Ishizaka A, Abraham E.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol. 288(5)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] 維持透析者における偽陽性P-ANCAの対応抗原としてのHMGB12005

    • Author(s)
      内村友則, 丸山征郎 ほか
    • Journal Title

      日本透析医学会雑誌 38・1

      Pages: 681-681

    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.2005

    • Author(s)
      Yamaji K, Abeyama K, Hashiguchi T, Uchimura T, Maruyama I. et al.
    • Journal Title

      Thrombosis Research. 115(4)

      Pages: 319-325

    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1 protein, a novel anti-inflammatory mechanism.2005

    • Author(s)
      Abeyama, K., Maruyama, I., et al.
    • Journal Title

      J Clin Invest (In press)

    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.2005

    • Author(s)
      Yamaji K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Thrombosis Research 115(4)

      Pages: 319-325

    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1 protein a novel anti-inflammatory mechanism2005

    • Author(s)
      Abeyama, K., Maruyama, I., et. al.
    • Journal Title

      J Clin Invest(peer reviewed) 115(5)

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel anti-inflammatory mechanism.2005

    • Author(s)
      Abeyama, K., Maruyama, I., et al.
    • Journal Title

      J Clin Invest 115・5

      Pages: 1267-1274

    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Roxithromycin inhibits angiogenesis of human hepatoma cells in vivo by suppressing VEGF production2005

    • Author(s)
      Aoki D, Ueno S, Kubo F, Oyama T, Sakuta T, Matsushita K, Maruyama I, Aikou T.
    • Journal Title

      Anticancer Res. 25(1A)

      Pages: 133-138

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370359
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.2005

    • Author(s)
      Yamaji K, Wang Y, Liu Y, Abeyama K, Hashiguchi T, Uchimura T, Krishna Biswas K, Iwamoto H, Maruyama I.
    • Journal Title

      Thromb Res. 115(4)

      Pages: 319-325

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] Roxithromycin inhibits angiogenesis of human hepatoma cells in vivo by suppressing VEGF production.2005

    • Author(s)
      Aoki D, Ueno S, Kubo F, Oyama T, Sakura T, Matsushita K, Maruyama I, Aikou T.
    • Journal Title

      Anticancer Res 25(1A)

      Pages: 133-138

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370359
  • [Journal Article] Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma(NB-1) cells by argatroban.2005

    • Author(s)
      Sarker KP, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Pathophysiology of Haemostasis and Thrombosis 34(1)

      Pages: 41-47

    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1) cells by argatroban.2005

    • Author(s)
      Sarker KP, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Pathophysiology of Haemostasis and Thrombosis 34・1

      Pages: 41-47

    • Data Source
      KAKENHI-PROJECT-17659294
  • [Journal Article] 腎結石形成モデルにおける腎不全発症機構についての研究2005

    • Author(s)
      大山陽子, 内村友則, 丸山征郎 ほか
    • Journal Title

      臨床化学 34・1

      Pages: 270-270

    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Studies on unfolded beta-microglobulin at C-terminal in dialysis-related amyloidosis.2005

    • Author(s)
      Motomiya Y, Ando Y, Amano I, Uchimura T, Maruyama I. et al.
    • Journal Title

      Kidney International 67(1)

      Pages: 314-320

    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation2005

    • Author(s)
      Yamaji, K., Abeyama, K., Hashiguchi, T.,Uchimura, T., Maruyama, I., et. al.
    • Journal Title

      Thromb Res 115(4)

      Pages: 319-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1 protein,a novel anti-inflammatory mechanism2005

    • Author(s)
      Abeyama, K., Maruyama, I., et. al.
    • Journal Title

      J CIin Invest 115・5

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Studies on unfolded beta-microglobulin at C-terminal in dialysis-related amyloidosis2005

    • Author(s)
      Motomiya Y, Ando Y, Amano I, Uchimura T, Maruyama I, et. al.
    • Journal Title

      Kidney International 67(1)

      Pages: 314-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma(NB-1) cells by argatroban2005

    • Author(s)
      Sarker, KP., Hashiguchi, T., Maruyama, I., et. al.
    • Journal Title

      Pathophysiology of Haemostasis and Thrombosis(peer reviewed) 34(1)

      Pages: 41-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidani properties and inhibits lipid peroxidation and advanced glycation end products formation2005

    • Author(s)
      Yamaji, K., Hashiguchi, T., Maruyama, I., et. al.
    • Journal Title

      Thrombosis Research(peer reviewed) 115(4)

      Pages: 319-25

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Studies on unfolded beta-microglobulin at C-terminal in dialysis-related amyloidosis2005

    • Author(s)
      Motomaiya, Y, Amano, I, Uchimura, T., Maruyama, I, et. al.
    • Journal Title

      Kidney International 67(1)

      Pages: 314-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] Inhibition of thrombin-induced vascular endothelial growth factor production in human neuroblastoma (NB-1)cells by argatroban2005

    • Author(s)
      Sarker KP, Hashiguchi T, Maruyama I, et. al.
    • Journal Title

      Pathophysiology of Haemostasis and Thrombosis 34(1)

      Pages: 41-7

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation2005

    • Author(s)
      Yamaji K, Abeyama K, Hashiguchi T, Uchimura T, Maruyama I., et. al.
    • Journal Title

      Thrombosis Research 115(4)

      Pages: 319-25

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590496
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1 protein, a novel anti-inflammatory mechanism.2005

    • Author(s)
      Abeyama, K., Maruyama, I., et al.
    • Journal Title

      J Clin Invest 115・(5)

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Roxithromycin inhibits constitutive activation of nuclear factor {kappa}B by deminishing oxidative stress in a rat model of hepatocellular carcinoma2005

    • Author(s)
      Ueno S, Aoki D, Kudo F, Hiwatashi K, Matsushita K, Oyama T, Maruyama I, Aikou T.
    • Journal Title

      Clin Cancer Res 11(15):

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370359
  • [Journal Article] Activated protein C,a natural anticoagulant protein,has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation2005

    • Author(s)
      Yamaji K, Hashiguchi T, Maruyama I, et. al.
    • Journal Title

      Thrombosis Research 115(4)

      Pages: 319-25

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation2005

    • Author(s)
      Yamaji K, Hashiguchi T, Maruyama I, et. al.
    • Journal Title

      Thrombosis Research 115(4)

      Pages: 319-25

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590888
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high mobility group-B1 protein, a novel anti-inflammatory mechanism.2005

    • Author(s)
      Abeyama, K., Maruyama, I., et al.
    • Journal Title

      J Clin Invest 115・5

      Pages: 1267-1274

    • Data Source
      KAKENHI-PROJECT-17659294
  • [Journal Article] Activated protein C, a natural anticoagulant protein, has antioxidant properties and inhibits lipid peroxidation and advanced glycation end products formation.2005

    • Author(s)
      Yamaji K, Hashiguchi T, Maruyama I, et al.
    • Journal Title

      Thrombosis Research 115(4)

      Pages: 319-325

    • Data Source
      KAKENHI-PROJECT-17390282
  • [Journal Article] The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism.2005

    • Author(s)
      Abeyama K, Stern DM, Ito Y, Kawahara K, Yoshimoto Y, Tanaka M, Uchimura T, Ida N, Yamazaki Y, Yamada S, Yamamoto Y, Yamamoto H, Iino S, Taniguchi N, Maruyama I.
    • Journal Title

      J Clin Invest. 115(5)

      Pages: 1267-1274

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] The antimetastatic role of thrombomodulin expression in islet cell-derived tumors and its diagnostic value.2004

    • Author(s)
      Iino S, Abeyama K, Kawahara K, Yamakuchi M, Hashiguchi T, Matsukita S, Yonezawa S, Taniguchi S, Nakata M, Takao S, Aikou T, Maruyama I.
    • Journal Title

      Clin Cancer Res. 10(18 pt.1)

      Pages: 6179-6188

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] 3章 血管内皮細胞による炎症・凝固系制御、-炎症反応系と血液凝固系のクロストーク-2004

    • Author(s)
      阿辺山和浩, 丸山征郎
    • Journal Title

      血管内皮細胞研究フロンティア

      Pages: 21-23

    • Data Source
      KAKENHI-PROJECT-16659493
  • [Journal Article] 病態生理 : 炎症とその制御システム2004

    • Author(s)
      阿辺山和浩, 丸山征郎
    • Journal Title

      日本臨床 62(12)

      Pages: 2229-2235

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] Contributions of high mobility group box in experimental and clinical acute lung injury.2004

    • Author(s)
      Ueno H, Matusda T, Tanaka, Maruyama I, Ishizaka A. et al.
    • Journal Title

      Am J Respir Crit Care Med. 170・(12)

      Pages: 1310-1316

    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Regulatory cross-talk between inflammation and blood coagulation. (in Japanese)2004

    • Author(s)
      Abeyama K, Maruyama I.
    • Journal Title

      Kekkan-Naihisaibou kenkyuu Frontier

      Pages: 21-23

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] Thrombomodulin expression on Langerhans' islet : can endogenous 'anticoagulant on demand' overcome detrimental thrombotic complications in clinical islet transplantation?2004

    • Author(s)
      Iino S, Abeyama K, Kawahara KI, Aikou T, Maruyama I.
    • Journal Title

      J Thromb Haemost. 2(5)

      Pages: 833-834

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] (総説)病態生理 炎症とその制御システム2004

    • Author(s)
      阿辺山和浩, 丸山征郎
    • Journal Title

      日本臨床 62(12)

      Pages: 2229-2235

    • Data Source
      KAKENHI-PROJECT-16659493
  • [Journal Article] Contributions of high mobility group box protein in experimental and clinical acute lung injury.2004

    • Author(s)
      Ueno H, Matsuda T, Hashimoto S, Amaya F, Kitamura Y, Tanaka M, Kobayashi A, Maruyama I, Yamada S, Hasegawa N, Soejima J, Koh H, Ishizaka A.
    • Journal Title

      Am J Respir Crit Care Med. 170(12)

      Pages: 1310-1316

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome.2004

    • Author(s)
      Motobe T, Komiya S, Maruyama I., et al.
    • Journal Title

      Shock 21・(1)

      Pages: 8-12

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Inflammation and its regulatory system. (in Japanese)2004

    • Author(s)
      Abeyama K, Maruyama I.
    • Journal Title

      Nippon Rinsho 62(12)

      Pages: 2229-2235

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] (総説)病態生理 炎症とその制御システム2004

    • Author(s)
      阿辺山和浩, 丸山征郎
    • Journal Title

      日本臨床 62(12)

      Pages: 2229-2235

    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] Endogenous cannabinoids are candidates for lipid mediators of bone cement implantation syndrome.2004

    • Author(s)
      Motobe T, Hashiguchi T, Uchimura T, Yamakuchi M, Taniguchi N, Komiya S, Maruyama I.
    • Journal Title

      Shock. 21(1)

      Pages: 8-12

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] 3章 血管内皮細胞による炎症・凝固系制御、-炎症反応系と血液凝固系のクロストーク-2004

    • Author(s)
      阿辺山和浩, 丸山征郎
    • Journal Title

      血管内皮細胞研究フロンティア

      Pages: 21-23

    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] Contributions of high mobility group box protein in experimental and clinical acute lung injury.2004

    • Author(s)
      Ueno H, Matsuda T, Tanaka, Maruyama I, Ishizaka A.et al.
    • Journal Title

      Am J Respir Crit Care Med. 170・(12)

      Pages: 1310-1316

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Decreased total nitric oxide production in patients with duchenne muscular dystrophy.2004

    • Author(s)
      Kasai T, Abeyama K, Hashiguchi T, Fukunaga H, Osame M, Maruyama I.
    • Journal Title

      J Biomed Sci. 11(4)

      Pages: 534-537

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390516
  • [Journal Article] Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis.2003

    • Author(s)
      Biswas KK, Hashiguchi T, Maruyama I.
    • Journal Title

      Hepatology 38・(5)

      Pages: 1167-1177

    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2.2003

    • Author(s)
      Yamada S, Inoue K, Yakabe K, Imaizumi H, Maruyama I.
    • Journal Title

      Clin Chem. 49(9)

      Pages: 1535-1537

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] High mobility group protein 1 (HMGB1) quantified by ELISA with a monoclonal antibody that does not cross-react with HMGB2.2003

    • Author(s)
      Yamada, S., Inoue, K., Yakabe, K., Imaizumi, H., Maruyama, I.
    • Journal Title

      Clin Chem 49・(9)

      Pages: 1535-1537

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Membrane cholesterol but not putative receptors mediates anandamide-induced hepatocyte apoptosis.2003

    • Author(s)
      Biswas KK, Sarker KP, Abeyama K, Kawahara K, Iino S, Otsubo Y, Saigo K, Izumi H, Hashiguchi T, Yamakuchi M, Yamaji K, Endo R, Suzuki K, Imaizumi H, Maruyama I.
    • Journal Title

      Hepatology. 38(5)

      Pages: 1167-1177

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390546
  • [Journal Article] Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase (POEMS) syndrome.2003

    • Author(s)
      Tokashiki T, Hashiguchi T, Arimura K, Eiraku N, Maruyama I, Osame M.
    • Journal Title

      Intern Med. 42(12)

      Pages: 1240-1243

    • NAID

      130000767039

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590901
  • [Journal Article] Highly accumulated platelet vascular endothelial growth factor in coagulant thrombotic region.2003

    • Author(s)
      Arisato T, Hashiguchi T, Sarker KP, Arimura K, Asano M, Matsuo K, Osame M, Maruyama I.
    • Journal Title

      J Thromb Haemost. (12)

      Pages: 2589-2593

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590901
  • [Journal Article] The agonist of the protease-activated receptor-1(PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells.2003

    • Author(s)
      Arisato T, Sarker KP, Kawahara K, Nakata M, Hashiguchi T, Osame M, Kitajima I, Maruyama I.
    • Journal Title

      Cell Mol Life Sci. 60(8)

      Pages: 1716-1724

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590901
  • [Journal Article] Association between reduced ADAMTS13 and diabetic nephropathy

    • Author(s)
      Taniguchi S, Hashiguchi T, Ono T, Takenouchi K, Nakayama K, Kawano T, Kato K, Matsushita R, Nagatomo M, Nakamura S, Nakashima T, Maruyama I
    • Journal Title

      Thromb Res (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Journal Article] Physical Adsorption of Human Thrombomodulin (ART-123) onto Polymeric Biomaterials for Developing an Antithrombogenic Blood-Contacting Material

    • Author(s)
      M.Matsusaki, M.Omichi, I.Maruyama, M.Akashi
    • Journal Title

      J.Biomed.Mater.Res. (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Journal Article] Vitreous Mediators after Intravitreal Bevacizumab or Triamcinolone Acetonide in Eyes with Proliferative Diabetic Retinopathy・

    • Author(s)
      Arimura N, Otsuka H, Yamakiri K, Sonoda Y, Nakao S, Noda Y, Hashiguchi T, Maruyama I, Sakamoto T.
    • Journal Title

      Ophthalmology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Journal Article] High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy.

    • Author(s)
      Oyama Y, Hashiguchi T, Taniguchi N, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda T, Umekita Y, Lotz M, Maruyama I
    • Journal Title

      Lab Invest (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 癌の診断デバイス2018

    • Inventor(s)
      堀貫治、平山真、丸山征郎、田口好弘、黒川洋、水口博義、小林謙也
    • Industrial Property Rights Holder
      広島大学、鹿児島大学、アルプスアルパイン、京都モノテック
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-092557
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-18K19587
  • [Patent] タンパク質分離デバイス、タンパク質を分離する方法、および、高マンノース型糖鎖の構造を決定する方法2015

    • Inventor(s)
      丸山征郎、堀貫治、坂口剛正、平山真、黒川洋
    • Industrial Property Rights Holder
      鹿児島大学、広島大学、旭化成メディカル㈱
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-026996
    • Filing Date
      2015-02-13
    • Data Source
      KAKENHI-PROJECT-26293385
  • [Patent] タンパク質分離デバイス、タンパク質を分離する方法、および、高マンノース型糖鎖の構造を決定する方法2015

    • Inventor(s)
      丸山征郎、堀貫治、坂口剛正、平山真、黒川洋
    • Industrial Property Rights Holder
      鹿児島大学、広島大学、旭化成メディカル㈱
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-026996
    • Filing Date
      2015-02-13
    • Data Source
      KAKENHI-PROJECT-26670790
  • [Patent] 糖尿病性腎症患者の病態把握方法2011

    • Inventor(s)
      橋口照人 谷口尚太郎 丸山征郎 小野智子 古崎文雄
    • Industrial Property Rights Holder
      鹿児島大学 他
    • Acquisition Date
      2011-11-25
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Patent] 歯周病特異的ペプチド、並びにそれを用いた歯周病の治療および診断2010

    • Inventor(s)
      丸山征郎, 橋口照人, タンジャルーンサランヤー, 川原幸一, 田中憲次, 李良子
    • Industrial Property Rights Holder
      鹿児島大学
    • Industrial Property Number
      2010-061673
    • Filing Date
      2010-03-17
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 歯周病特異的ペプチド、並びにそれを用いた歯周病の治療および診断2010

    • Inventor(s)
      丸山征郎、橋口照人, タンジャルーン サランヤー, 川原幸一, 田中憲次, 李良子
    • Industrial Property Rights Holder
      鹿児島大学
    • Industrial Property Number
      2010-061673
    • Filing Date
      2010-03-17
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 新規癌マーカーおよびそれを用いた診断2009

    • Inventor(s)
      橋口照人, 夏越祥次, 丸山征郎, 田中憲次, 李良子
    • Industrial Property Rights Holder
      鹿児島大学
    • Filing Date
      2009-01-07
    • Acquisition Date
      2009-07-16
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 新規癌マーカーおよびそれを用いた診断2008

    • Inventor(s)
      丸山征郎、橋口照人、夏越祥次、田中憲次、李 良子
    • Industrial Property Rights Holder
      鹿児島大学(株)プロトセラ
    • Industrial Property Number
      2008-000776
    • Filing Date
      2008-01-07
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 新規癌マーカーおよびそれを用いた診断2008

    • Inventor(s)
      橋口照人, 夏越祥次, 丸山征郎, 田中憲次, 李良子
    • Industrial Property Rights Holder
      鹿児島大学
    • Industrial Property Number
      2008-000776
    • Filing Date
      2008-01-07
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 新規疾患マーカーおよびそれを用いた診断2007

    • Inventor(s)
      橋口照人, 夏越祥次, 丸山征郎, 田中憲次, 李良子
    • Industrial Property Rights Holder
      鹿児島大学
    • Filing Date
      2007-12-12
    • Acquisition Date
      2008-06-19
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 新規癌マーカーおよびそれを用いた診断2007

    • Inventor(s)
      橋口照人, 夏越祥次, 丸山征郎, 田中憲次, 李良子
    • Industrial Property Rights Holder
      鹿児島大学
    • Industrial Property Number
      2008-549347
    • Filing Date
      2007-12-12
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Patent] 多孔質基材2006

    • Inventor(s)
      上野良之, 菅谷博之, 舩木隆文, 加藤真哉, 明石満, 丸山征郎
    • Industrial Property Rights Holder
      東レ株式会社, 株式会社ビーエムテイーハイブリッド, 明石満, 丸山征郎
    • Patent Publication Number
      2007-029716
    • Filing Date
      2006-06-20
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Patent] 放射線照射された改質基材2005

    • Inventor(s)
      上野良之, 菅谷博之, 舩木隆文, 加藤真哉, 明石満, 丸山征郎
    • Industrial Property Rights Holder
      東レ株式会社, 株式会社ビーエムテイーハイブリッド, 明石満, 丸山征郎
    • Patent Publication Number
      2006-271809
    • Filing Date
      2005-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Patent] 体外循環医療カラム用補助用具2005

    • Inventor(s)
      上野 良之, 菅谷 博之, 舩木 隆文, 加藤 真哉, 明石 満, 丸山 征郎
    • Industrial Property Rights Holder
      東レ株式会社, 株式会社ビーエムティーハイブリッド, 明石 満, 丸山 征郎
    • Filing Date
      2005
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Patent] 放射線照射された改質基材2005

    • Inventor(s)
      上野 良之, 菅谷 博之, 舩木 隆文, 加藤 真哉, 明石 満, 丸山 征郎
    • Industrial Property Rights Holder
      東レ株式会社, 株式会社ビーエムティーハイブリッド, 明石 満, 丸山 征郎
    • Filing Date
      2005
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Patent] 多孔質基材2005

    • Inventor(s)
      上野 良之, 菅谷 博之, 舩木 隆文, 加藤 真哉, 明石 満, 丸山 征郎
    • Industrial Property Rights Holder
      東レ株式会社, 株式会社ビーエムティーハイブリッド, 明石 満, 丸山 征郎
    • Filing Date
      2005
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Patent] 体外循環医療カラム用補助用具2005

    • Inventor(s)
      上野良之, 菅谷博之, 舩木隆文, 加藤真哉, 明石満, 丸山征郎
    • Industrial Property Rights Holder
      東レ株式会社, 株式会社ビーエムテイーハイブリッド, 明石満, 丸山征郎
    • Patent Publication Number
      2006-271839
    • Filing Date
      2005-03-30
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16300156
  • [Presentation] 抗酸化力を高める意義| 術後癒着に備える2021

    • Author(s)
      菊池 清志, 瀬戸山 健太郎, 大塚 章太郎, 高田 聖也, 中西 和毅, 則松 貢輔, 谷 明, 榊間 春利, 川原 幸一, 丸山 征郎, 田中 永一郎, 内門 久明
    • Organizer
      第18回 予防医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K11640
  • [Presentation] 抗酸化力を高める意義| 脳梗塞の発症・加療に備える2021

    • Author(s)
      菊池 清志, 瀬戸山 健太郎, 大塚 章太郎, 高田 聖也, 中西 和毅, 則松 貢輔, 谷 明, 榊間 春利, 川原 幸一, 丸山 征郎, 田中 永一郎
    • Organizer
      第18回 予防医学会学術総会
    • Data Source
      KAKENHI-PROJECT-20K11640
  • [Presentation] 細胞外Nucleophosminの受容体は TLR-4である2020

    • Author(s)
      中富康太, 董建暉, 金本一誠, Ronny Christiadi Salim, 上野光理, Salunya Tancharoen, 菊池清志 伊藤隆史, 丸山征郎, 川原幸一
    • Organizer
      日本薬学会
    • Data Source
      KAKENHI-PROJECT-18H02906
  • [Presentation] ヒストンH2AとH2BはMD2/ERK1/2を介してTNF-αを誘導する2020

    • Author(s)
      上野 光理, Ronny Christiadi Salim, 石濱 一貴, 朝田 成重, 山下 侑子, Tancharoen Salunya, 菊池 清志, 伊藤 隆史, 丸山 征郎, 川原 幸一
    • Organizer
      第42回日本血栓止血学会学術集会
    • Data Source
      KAKENHI-PROJECT-18H02906
  • [Presentation] Effects of detraining on neuroprotective effects due to preconditioning exercise-induced brain tolerance after ischemic stroke of rat.2020

    • Author(s)
      Shotaro Otsuka, Akira Tani, Yuki Itashiki, Kosuke Norimatu, Seiya Takada, Kazuki Nakanishi, Maruyama Ikuro, Harutoshi Sakakima.
    • Organizer
      第43回日本神経科学学会
    • Data Source
      KAKENHI-PROJECT-20H04039
  • [Presentation] recombinant TM の開発ーDICトリガー因子:トロンビンのベクトル変換によるDIC治療ストラテジー2019

    • Author(s)
      丸山 征郎
    • Organizer
      第41回日本血栓止血学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] TNF-a induction by Histone H2A and H2B is mediated via ERK1/2 in RAW264.7 cells.2019

    • Author(s)
      Hikari Ueno, Kota Nakatomi, Shuto Anan, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara
    • Organizer
      International DAMPs and Alarmins Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02906
  • [Presentation] TNF-a induction by Histone H2A and H2B is mediated via ERK1/2 in RAW264.7 cells.2019

    • Author(s)
      Ueno H, Nakatomi K, Anan S, Tancharoen S, Kikuchi K, Ito T, Maruyama I, Kawahara KI
    • Organizer
      9th International DAMPs and Alarmins Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03926
  • [Presentation] The extracellular Nucleophosmin Receptor is TLR-42019

    • Author(s)
      Kota Nakatomi, Ronny Christiadi Salim, Issey Kanemoto, Hikari Ueno, Dong Jianhui, Salunya Tancharoen, Kiyoshi Kikuchi, Takashi Ito, Ikuro Maruyama, Ko-ichi Kawahara.
    • Organizer
      International DAMPs and Alarmins Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02906
  • [Presentation] Chinese herbal medicine "Wu Ling San" had a renal protecting function in crystal induced granulomatous nephritis in rats.2019

    • Author(s)
      Oyama Y, Tancharoen S, Ito T, Yamakuchi M, Higashi S, Hashiguchi T, Maruyama I.
    • Organizer
      9th International Symposium DAMPS and HMGB1, Okayama, Japan 2019.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09310
  • [Presentation] Endothelial anticoagulant thrombomodulin binds and neutralizes HMGB1, histones and LPS, and induces resolution of damage through protein C activation2019

    • Author(s)
      Ikuro Maruyama
    • Organizer
      9th International DAMPs and Alarmins Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] 尿酸は rtPA線溶効果を増強するか?― 脳梗塞急性期治療における閉塞血管の再開通率向上を目指して―2019

    • Author(s)
      菊池清志, 伊藤隆史, 瀬戸山健太郎, 細川和也, 丸山征郎
    • Organizer
      第19回 TTMフォーラム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K10746
  • [Presentation] 急性血液浄化の新視点:exosomeとRAMPs2018

    • Author(s)
      丸山 征郎
    • Organizer
      第29回日本急性血液浄化学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] 急性血液浄化の新視点:exosomeとRAMPMs2018

    • Author(s)
      丸山 征郎
    • Organizer
      第29回日本急性血液浄化学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19587
  • [Presentation] The impact of endothelial marker on catheter ablation in patients with atrial fibrillation2018

    • Author(s)
      Namino F, Yamakuchi M, Iriki Y, Okui H, Ichiki H, Maenosono R, Masamoto I, Hashiguchi T, Ohishi M, Maruyama I
    • Organizer
      The 10th Congress of the Asian-Pacific Society on Thrombosis and Hemostasis
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05229
  • [Presentation] 病態拡大の新しい使者:exosomeが参画した新しいショック病2018

    • Author(s)
      丸山 征郎
    • Organizer
      第33回日本Shock学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] 血管作動因子としてのPAMPs/DAMPsとその作用2018

    • Author(s)
      丸山征郎
    • Organizer
      第47回日本心脈管作動物質学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] 病態拡大の新しい使者:exosomeが参画した新しいショック病像2018

    • Author(s)
      丸山 征郎
    • Organizer
      第33回日本Shock学会総会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K19587
  • [Presentation] エクソソームとshock、炎症との関わり2017

    • Author(s)
      丸山征郎
    • Organizer
      日本集中治療医学会 第1回東海北陸支部学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] 血管内皮細胞と動脈硬化2017

    • Author(s)
      丸山征郎
    • Organizer
      第49回日本動脈硬化学会総会・学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H04363
  • [Presentation] CalDAG-GEFI分子異常による血小板機能異常症2017

    • Author(s)
      古城 剛、山口宗一、吉村明子、竹之内和則、伊藤隆史、清水利昭、大山陽子、郡山豊泰、波野史典、Sushil Panta 、松下昌風、丸山征郎、髙嶋 博、橋口照人
    • Organizer
      第62回日本臨床検査医学会 九州地方会 第28回日本臨床化学会 九州支部総会
    • Place of Presentation
      久留米大学病院 筑水会館(福岡県久留米市)
    • Data Source
      KAKENHI-PROJECT-16H05229
  • [Presentation] Novel Thrombogenicity Examination of Whoel Blood: Total Thronbus-formation Analysis System in Dogs2017

    • Author(s)
      Tomoko Iwanaga, Shusaku Yamada, Ryuji Fukushima, Tomoka Nagasato, Ikuro Maruyama, Naoki Miura
    • Organizer
      2017 American College of Veterinary Internal Medicine Forum
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08054
  • [Presentation] 感染防御とその破綻のシステムバイオロジー2017

    • Author(s)
      丸山征郎
    • Organizer
      第13回九州小児免疫フォーラム
    • Place of Presentation
      ホテルセントラーザ博多(福岡県福岡市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15763
  • [Presentation] 救急患者体内の役者達:PAMPs/DAMPsそしてRAMPs2016

    • Author(s)
      丸山征郎
    • Organizer
      第20回日本救急医学会九州地方会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293385
  • [Presentation] Anti-inflammatory and anticoagulant roles of thrombomodulin in sepsis-associated DIC2016

    • Author(s)
      Takashi Ito, and Ikuro Maruyama
    • Organizer
      1st joint Meeting of ISFP and PA workshop
    • Place of Presentation
      日本平ホテル(静岡県静岡市)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H05684
  • [Presentation] 救急患者体内の役者達:PAMPs/DAMPsそしてRAMPs2016

    • Author(s)
      丸山征郎
    • Organizer
      第20回日本救急医学会九州地方会
    • Place of Presentation
      かごしま県民交流センター(鹿児島県鹿児島市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15763
  • [Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016

    • Author(s)
      古城 剛, 山口 宗一, 吉村 明子, 竹之内 和則, 伊藤 隆史, 清水 利昭, 大山 陽子, 郡山 豊泰, Sushil Panta, 松下 昌風, 丸山 征郎, 高嶋 博, 橋口 照人
    • Organizer
      第38回日本血栓止血学会学術集会
    • Place of Presentation
      奈良春日野国際フォーラム(奈良県奈良市)
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-15K15196
  • [Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016

    • Author(s)
      古城 剛, 山口 宗一, 吉村 明子, 竹之内 和則, 伊藤 隆, 清水 利昭, 大山 陽子, 郡山 豊泰, Panta Sushil, 松下 昌風, 丸山 征郎, 高嶋 博, 橋口 照人
    • Organizer
      第63回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-09-01
    • Data Source
      KAKENHI-PROJECT-26293130
  • [Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016

    • Author(s)
      古城 剛、山口宗一、吉村明子、竹之内和則、伊藤隆史、清水利昭、大山陽子、郡山豊泰、Sushil Panta 、松下昌風、丸山征郎、髙嶋 博、橋口照人
    • Organizer
      第38回日本血栓止血学会学術集会
    • Place of Presentation
      奈良春日野国際フォーラム~I・RA・KA~(奈良県奈良市)
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-16H05229
  • [Presentation] 血栓形成に関する新しい機序とトロンビンの役割2016

    • Author(s)
      丸山征郎
    • Organizer
      第120回日本循環器学会九州地方会
    • Place of Presentation
      ホルトホール大分(大分県大分市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15763
  • [Presentation] 出血傾向を全血血栓形成観測システム(T-TAS)により確認できた犬の3例2016

    • Author(s)
      安川洋子、山田修作、河口貴恵、平尾大樹、橋本梨那、永里朋香、丸山征郎、三浦直樹、岩永朋子、福島隆治
    • Organizer
      第37回動物臨床医学年次大会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2016-11-18
    • Data Source
      KAKENHI-PROJECT-16K08054
  • [Presentation] 血栓形成に関する新しい機序とトロンビンの役割2016

    • Author(s)
      丸山征郎
    • Organizer
      第120回日本循環器学会九州地方会
    • Place of Presentation
      ホルトホール大分(大分県大分市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293385
  • [Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016

    • Author(s)
      古城 剛, 山口 宗一, 吉村 明子, 竹之内 和則, 伊藤 隆, 清水 利昭, 大山 陽子, 郡山 豊泰, Panta Sushil, 松下 昌風, 丸山 征郎, 高嶋 博, 橋口 照人
    • Organizer
      第63回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2016-09-01
    • Data Source
      KAKENHI-PROJECT-15K15196
  • [Presentation] Thrombin-thrombomodulin system in the hemostatic system and its clinical implication2016

    • Author(s)
      Ikuro Maruyama,and Takashi Ito
    • Organizer
      The 1st Joint Meeting of ISFP/PA Workshop
    • Place of Presentation
      日本平ホテル(静岡県静岡市)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15763
  • [Presentation] CalDAG-GEFI分子異常により血小板機能異常を呈した一症例2016

    • Author(s)
      古城 剛, 山口 宗一, 吉村 明子, 竹之内 和則, 伊藤 隆史, 清水 利昭, 大山 陽子, 郡山 豊泰, Sushil Panta, 松下 昌風, 丸山 征郎, 高嶋 博, 橋口 照人
    • Organizer
      第38回日本血栓止血学会学術集会
    • Place of Presentation
      奈良春日野国際フォーラム(奈良県奈良市)
    • Year and Date
      2016-06-16
    • Data Source
      KAKENHI-PROJECT-26293130
  • [Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
    • Organizer
      西日本生理学会
    • Place of Presentation
      久留米
    • Year and Date
      2015-10-09
    • Data Source
      KAKENHI-PROJECT-26670793
  • [Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田 哲 丸山征郎、川原幸一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26670793
  • [Presentation] 細胞外ヒストンによる炎症性サイトカインIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田哲、丸山征郎、菊池清志、川原幸一
    • Organizer
      西日本生理学会
    • Place of Presentation
      久留米
    • Year and Date
      2015-10-09
    • Data Source
      KAKENHI-PROJECT-26293387
  • [Presentation] 細胞外ヒストンにおけるIL-1β放出機構の解明2015

    • Author(s)
      大池加恵、勝野涼太、藤本靖真、安田 哲 丸山征郎、川原幸一
    • Organizer
      日本分子生物学会年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26293387
  • [Presentation] Regulation of Danger Signals from HMGB1and Histones by Endothelial or Circulating Thrombomodulin2013

    • Author(s)
      Ikuro Maruyama
    • Organizer
      The Merinoff World Congress 2013 : HMGB1
    • Place of Presentation
      Manhasset, NY
    • Data Source
      KAKENHI-PROJECT-25670764
  • [Presentation] Massive thrombosis evoked by extracellular histones : Is it DIC?2013

    • Author(s)
      Takashi Ito, Mayumi Nakahara, and Ikuro Maruyama
    • Organizer
      59th Scientific and Standardization Committee Meeting of the ISTH 2013
    • Place of Presentation
      オランダ.
    • Data Source
      KAKENHI-PROJECT-25670763
  • [Presentation] Assay method of des-HMGB12013

    • Author(s)
      Ikuro Maruyama, Takashi Ito, Yoshio Azuma, Mayumi Nakahara, Teruto Hashiguchi, Shingo Yamada
    • Organizer
      N-terminus cleaved out HMGB1 by thrombin-thrombomodulin, and its clinical significance XXIVcongress of the ISTH
    • Place of Presentation
      Amsterdam, The Netherlands
    • Data Source
      KAKENHI-PROJECT-25670764
  • [Presentation] Assay method of des-HMGB1, N-terminus cleaved out HMGB1 by thrombinthrombomodulin, and its clinical significance2013

    • Author(s)
      Ikuro Maruyama, Takashi Ito, Yoshio Azuma, Mayumi Nakahara, Teruto Hashiguchi, Shingo Yamada
    • Organizer
      XXIVcongress of the ISTH
    • Place of Presentation
      Amsterdam, The Netherlands
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Presentation] Assay method of Des-HMGB1, N-terminus cleaved out HMGB1 by thrombin-thrombomodulin and its clinical significance2013

    • Author(s)
      kuro Maruyama, Takashi Ito, Shigo Yamada
    • Organizer
      XXIV Congress of the ISTH
    • Data Source
      KAKENHI-PROJECT-24659798
  • [Presentation] Regulation of Danger Signals from HMGB1and Histones by Endothelial or Circulating Thrombomodulin2013

    • Author(s)
      Ikuro Maruyama
    • Organizer
      The Merinoff World Congress 2013 : HMGB1
    • Place of Presentation
      Manhasset, NY
    • Data Source
      KAKENHI-PROJECT-23390412
  • [Presentation] イチゴエキスはHMGB1の放出を抑制する2013

    • Author(s)
      大池加恵、上村龍平、丸山征郎、川原幸一
    • Organizer
      2013年度日本生物高分子学会
    • Place of Presentation
      大阪
    • Year and Date
      2013-11-20
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Presentation] イチゴの新規機能 : HMGB1放出抑制2012

    • Author(s)
      上村龍平、大池加恵、丸山征郎、川原幸一
    • Organizer
      第85回生化学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-15
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Presentation] 内臓平滑筋 human VEGF-A 発現マウスにおける膵インスリン陽性細胞の構築変化2012

    • Author(s)
      竹之内和則、永里 朋香、清水 利明、丸山 征郎、橋口 照人
    • Organizer
      第59回日本臨床検査医学会学術集
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Presentation] イチゴの新規機能 : HMGB1放出抑制2012

    • Author(s)
      上村龍平、大池加恵、丸山征郎、川原幸一
    • Organizer
      第51回日本栄養・食糧学会近畿支部大会
    • Place of Presentation
      兵庫
    • Year and Date
      2012-10-20
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Presentation] 免疫B細胞発現VEGF-Aによるリンパ節リモデリングと免疫環境の機能的制2012

    • Author(s)
      橋口照人、伊藤隆史、SHRESTHA B、三浦直樹、丸山征郎
    • Organizer
      第34回日本血栓止血学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22390179
  • [Presentation] イチゴの新規機能 : HMGB1放出抑制2012

    • Author(s)
      上村龍平、大池加恵、丸山征郎、川原幸一
    • Organizer
      第35回日本分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-24659804
  • [Presentation] Recombinant thrombomodulin and HMGB12011

    • Author(s)
      Ito T, and Maruyama I.
    • Organizer
      American Heart Association Scientific Sessions 2011(Cardiovascular Seminar CVS. 705)
    • Place of Presentation
      米国オーランド
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-23890166
  • [Presentation] NSAIDs点眼による脈絡膜血管新生抑制2011

    • Author(s)
      吉永就正, 有村昇, 大塚寛樹, 竹之内和則, 貞村ゆかり, 野間聖, 川原幸一, 園田祥三, 橋口照人, 丸山征郎, 坂本泰二
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] Nsaids Eye Drop As Anti-oxidant Treatment In Choroidal Neovascularization2011

    • Author(s)
      Narimasa Yoshinaga, Noboru Arimura, Shozo Sonoda, Kazunori Takenouchi, Yukari Sadamura, Satoshi Noma, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama, Taiji Sakamoto
    • Organizer
      ARVO2011
    • Place of Presentation
      Fort Lauderdale・U. S. A
    • Year and Date
      2011-05-02
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] Nsaids Eye Drop As Anti-oxidant Treatment In Choroidal Neovascularization2011

    • Author(s)
      Narimasa Yoshinaga, Noboru Arimura, Shozo Sonoda, Kazunori Takenouchi, Yukari Sadamura, Satoshi Noma, Ko-ichi Kawahara, Teruto Hashiguchi, Ikuro Maruyama, Taiji Sakamoto
    • Organizer
      ARVO2011
    • Place of Presentation
      Fort Lauderdale・U.S.A
    • Year and Date
      2011-05-02
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] Endothelial function as an objective assessment tool of fatigue in healthy individuals2010

    • Author(s)
      Ohno Y, Hashiguchi T, Maenosono R, Yamashita H, Taira Y, Minowa K, Yamashita Y, Kato Y, Kawahara K, Maruyama I
    • Organizer
      ICOHN&ACOHN Joint Conference2010
    • Place of Presentation
      Yokohama
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Presentation] HMGBIのトロンビン・トロンボモジュリンによる制御機構2009

    • Author(s)
      川原幸一, 伊藤隆史, 橋口照人, 丸山征郎
    • Organizer
      第12回日本異種移植研究会
    • Place of Presentation
      鹿児島
    • Year and Date
      2009-03-07
    • Data Source
      KAKENHI-PROJECT-17100007
  • [Presentation] Therapeutic strategy for circulating "bad" HMGB1 in septic shock.2009

    • Author(s)
      Maruyama I.
    • Organizer
      第2回HMGB1会議
    • Place of Presentation
      ハンブルグ(ドイツ)
    • Year and Date
      2009-09-25
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Presentation] 裂孔原性網膜剥離における硝子体中SDF-1とその他のサイトカイン2009

    • Author(s)
      大塚寛樹, 有村 昇, 山切啓太, 橋口照人, 丸山征郎
    • Organizer
      厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 平成20年度班会議
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Year and Date
      2009-01-17
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] 網膜剥離における High-mobility group box 1 protein の関与2009

    • Author(s)
      有村昇, 喜井裕哉, 橋口照人, 川原幸一, 中村誠, 園田恭志, 山切啓太, 大久保明子, 丸山征郎, 坂本泰二
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2009-04-17
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] 網膜剥離における視細胞死とHigh-mobility group box 1 Protein2009

    • Author(s)
      有村 昇, 喜井裕哉, 橋口照人, 川原幸一, 中村 誠, 園田恭志, 山切啓太, 大久保明子, 丸山征郎, 坂本泰二
    • Organizer
      厚生労働省難治性疾患克服研究事業 網膜脈絡膜・視神経萎縮症調査研究班 平成20年度班会議
    • Place of Presentation
      名古屋市立大学(名古屋市)
    • Year and Date
      2009-01-17
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] Therapeutic strategy for circulating "bad" HMGB1 in septic shock2009

    • Author(s)
      Maruyama I
    • Organizer
      第2回HMGB1会議
    • Place of Presentation
      ハンブルグ(ドイツ)
    • Year and Date
      2009-09-25
    • Data Source
      KAKENHI-PROJECT-20390274
  • [Presentation] Concentration of Cytokines After Intravitreous Injection of Bevacizumab or Triamcinolone.2008

    • Author(s)
      Otsuka H, Arimura N, Ki-I Y, Yamakiri K, Doi N, Hashiguchi T, Maruyama I, Sakamoto T.
    • Organizer
      The Association for Reseach in Vision and ophthalmology.
    • Place of Presentation
      Fort Lauderdale, U. S. A
    • Data Source
      KAKENHI-PROJECT-20390450
  • [Presentation] ヒトリンパ細胞はブタ内皮細胞を標的・活性化しHigh Mobility Group Box 1 (HMGB1)を発現誘導する2008

    • Author(s)
      川原幸一、高尾尊身、丸山征郎
    • Organizer
      第11回異種移植研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-02-23
    • Data Source
      KAKENHI-PROJECT-17100007
  • [Presentation] ヒトリンパ球細胞はブタ内皮細胞を標的・活性化しHMGB1を発現誘導する2008

    • Author(s)
      川原幸一、瀬戸山健太郎、菊池清志、上村亮三、三浦直樹、森元陽子、高尾尊身、橋口照人、丸山征郎
    • Organizer
      第11回日本異種移植研究会
    • Place of Presentation
      国立循環器病センター
    • Year and Date
      2008-02-23
    • Data Source
      KAKENHI-PROJECT-17100007
  • [Presentation] RH-PAT(Reactive hyperemia-peripheral arterial tonometry)解析による血管内皮細胞機能に与える影響因子の多様性2008

    • Author(s)
      大野佳子, 前之園隆一, 橋口照人, 丸山征郎, 他
    • Organizer
      第19回九州血管血栓フォーラム
    • Place of Presentation
      鹿児島大学 鶴陵会館(鹿児島市)
    • Year and Date
      2008-11-09
    • Data Source
      KAKENHI-PROJECT-19650184
  • [Presentation] Degradation of non-hemostatic molecules in the state of DIC/MOF2008

    • Author(s)
      橋口照人, 川原幸一, 丸山征郎, 李良子, 田中憲次
    • Organizer
      第12回エンドトキシン血症救命治療研究会
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Presentation] RH-PATによる血管内皮細胞機能の評価第3報-内皮細胞機能障害因子, 性差との関連解析-.2008

    • Author(s)
      前之園隆一, 大野佳子, 橋口照人, 丸山征郎, 他
    • Organizer
      第19回九州血管血栓フォーラム
    • Place of Presentation
      鹿児島大学 鶴陵会館(鹿児島市)
    • Year and Date
      2008-11-09
    • Data Source
      KAKENHI-PROJECT-19650184
  • [Presentation] DIC/MOFにおける非止血関連分子の崩壊2008

    • Author(s)
      橋口照人, 李良子, 田中憲次, 丸山征郎
    • Organizer
      日本血栓止血学会学術標準化委員会(SSC)シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Presentation] DIC/MOFにおける生体内蛋白分解の網羅的解析2007

    • Author(s)
      橋口照人, 川原幸一, 丸山征郎, 李良子, 田中憲次
    • Organizer
      第13回日本エンドトキシン研究会
    • Place of Presentation
      鹿児島
    • Data Source
      KAKENHI-PROJECT-19390156
  • [Presentation] Reactive hyperemia peripheral arterial tonometory (RH-PAT)を用いた血管内皮細胞機能評価の臨床応用についての研究2007

    • Author(s)
      前之園隆一, 大野佳子, 橋口照人, 黒木辰雄, 丸山征郎
    • Organizer
      第7回臨床血液脈波研究会
    • Place of Presentation
      大阪市
    • Year and Date
      2007-06-02
    • Data Source
      KAKENHI-PROJECT-19650184
  • [Presentation] ヒトリンパ細胞はブタ内皮細胞を標的・活性化しHigh Mobility Group Box 1 (HMGB1)を発現誘導する2007

    • Author(s)
      川原幸一、高尾尊身、丸山征郎
    • Organizer
      第10回日本異種移植研究会
    • Place of Presentation
      東京
    • Year and Date
      2007-03-10
    • Data Source
      KAKENHI-PROJECT-17100007
  • [Presentation] Reactive hyperemia peripheral arterial tonometory (RH-PAT)による血管内皮細胞機能の評価-内皮機能障害因子との関連の解析2007

    • Author(s)
      前之園隆一, 大野佳子, 橋口照人, 黒木辰雄, 丸山征郎
    • Organizer
      第5回日本予防医学学会学術集会
    • Place of Presentation
      指宿市
    • Year and Date
      2007-11-24
    • Data Source
      KAKENHI-PROJECT-19650184
  • [Presentation] 健常人に対するRH-PAT(Reactive hyperemia-peripheral artery tonometry)による血管内皮細胞機能の検証2007

    • Author(s)
      大野佳子, 前之園隆一, 橋口照人, 丸山征郎, 加藤裕子
    • Organizer
      第5回日本予防医学学会学術集会
    • Place of Presentation
      指宿市
    • Year and Date
      2007-11-24
    • Data Source
      KAKENHI-PROJECT-19650184
  • [Presentation] Degradation of homeostatic molecules in the state of DIC/MOF2007

    • Author(s)
      橋口照人、李 良子、田中憲次、丸山征郎
    • Organizer
      第30回日本血栓止血学会学術集会
    • Place of Presentation
      三重県
    • Year and Date
      2007-11-17
    • Data Source
      KAKENHI-PROJECT-19390156
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  • 94.  SUDA Yasuo (70179282)
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  • 95.  KAWAGUCHI HIROAKI (60325777)
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  • 96.  KINOSHITA ASUKA (00396813)
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    # of Collaborated Products: 0 results
  • 97.  MATSUMOTO Masanori (60316081)
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    # of Collaborated Products: 1 results
  • 98.  HAYAKAWA Masaki (30516729)
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  • 99.  IZUMO Shuji (30143811)
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  • 100.  NOMOTO Masahiro (50208401)
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    # of Collaborated Products: 0 results
  • 101.  SONODA Shunro (40036463)
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  • 102.  NISHIOKA Kusuki (60049070)
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    # of Collaborated Products: 0 results
  • 103.  SUMIDA Takayuki (00183054)
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  • 104.  NAKAGAWA Masanori (50198040)
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    # of Collaborated Products: 0 results
  • 106.  KAKEI Masafumi (90214270)
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    # of Collaborated Products: 0 results
  • 107.  TSUDA Hiroko (30180003)
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  • 108.  SHIMOTAKAHARA Tetsuro (80216126)
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    # of Collaborated Products: 0 results
  • 109.  MATSUSHITA Yoshifumi (90244227)
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  • 110.  SATO Eiichi (60004579)
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  • 111.  OHIRA Yoshinobu (50185378)
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    # of Collaborated Products: 0 results
  • 112.  SEMBA Ichiro (60145505)
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  • 113.  YAMADA Nobuhiro (40200729)
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    # of Collaborated Products: 0 results
  • 114.  HORIUCHI Seikoh (10117377)
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    # of Collaborated Products: 0 results
  • 115.  ANDO Joji (20159528)
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  • 116.  SATOH Shinji (60274445)
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  • 117.  OHARA Yuichi (90185364)
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  • 118.  UNOKI Kazuhiko (60193926)
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    # of Collaborated Products: 0 results
  • 119.  SHIGETA Koki (10274854)
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  • 120.  OGURA Tadashi (00059362)
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  • 121.  KAWAHIRA Kazumi (20117493)
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    # of Collaborated Products: 0 results
  • 122.  TEI Chuwa (10163891)
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  • 123.  HORIKIRI Yutaka (10199549)
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  • 124.  UMEHARA Fujio (20271140)
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  • 125.  NAGAOKA Shigetaka (10155913)
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  • 126.  KANMURA Yuichi (30211189)
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  • 127.  TAKEDA Kazunori (20171639)
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  • 128.  MATSUNO Seiki (80004737)
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  • 129.  SUNAMURA Makoto (10201584)
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    # of Collaborated Products: 0 results
  • 130.  MAJIMA Hideyuki (60165701)
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    # of Collaborated Products: 0 results
  • 131.  OZAWA Toshihiko (40160858)
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    # of Collaborated Products: 0 results
  • 132.  TOMITA Kazuo (60347094)
    # of Collaborated Projects: 1 results