YAMANO Yoshihisa 山野嘉久

Researcher Number	80445882
Other IDs
Affiliation (Current)	2020: 聖マリアンナ医科大学, 医学部, 教授 2020: 聖マリアンナ医科大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2016 – 2019: 聖マリアンナ医科大学, 医学研究科, 教授 2010 – 2015: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 准教授 2008 – 2011: St.Marianna University School of Medicine, 難病治療研究センター, 准教授 2009: 聖まマリアンナ医科大学, 難病治療研究センター, 准教授 2007 – 2008: St.Marianna University School of Medicine, 難病治療研究センター, 講師
Review Section/Research Field	Principal Investigator Neurology / Basic Section 52020:Neurology-related Except Principal Investigator Biological Sciences / 膠原病・アレルギー・感染症内科学
Keywords	Principal Investigator 神経病態免疫学 / HTLV-1 / HAM / CD4+CD25+CCR4+ / FoxP3 / CTLA-4 / Interferon-γ / interleukin-2 / Interleukin-17 / HTLV-I … More Except Principal Investigator 関節リウマチ / シノビオリン / 滑膜細胞増殖 / 転写制御 / E3ユビキチンリガーゼ / 基質 / ノックアウトマウス / 滑膜細胞 / ESコビキチンリガーゼ / 転写複合体 / 小胞体ストレス / 線維化 / 分泌タンパク質 / 慢性炎症 / コンディショナルノックアウト / アポトーシス / 肝硬変 / サイトカイン / 滑膜細胞細胞 / 分泌 / ユビキチン化 / 小胞体関連分解 / コンディショナルノックアウトマウス / 化合物 / 生化学的手法 / T細胞 / リウマチ学 / 細胞分子生物学 / 滑膜炎 / 細胞増殖 / 炎症 / SPACIA1 Less

HAMのHTLV-1感染細胞の異常形質を規定するゲノム・エピゲノム制御機構の解析Principal InvestigatorOngoing
- Principal Investigator
  
  山野嘉久
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  St. Marianna University School of Medicine
Integrative analysis of epigenome abnormality in the pathogenesis of HTLV-1-associated myelopathy.Principal Investigator
- Principal Investigator
  
  Yamano Yoshihisa
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  St. Marianna University School of Medicine
Analysis of newly identified pathogenic CD4+ helper T-cells in patients with HTLV-1-associated myelopathyPrincipal Investigator
- Principal Investigator
  
  Yamano Yoshihisa
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  St. Marianna University School of Medicine
Development of regenerative medicine for spinal cord injury in HTLV-1 associated myelopathyPrincipal Investigator
- Principal Investigator
  
  YAMANO Yoshihisa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  St. Marianna University School of Medicine
Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.
- Principal Investigator
  
  FUJII Ryoji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  St. Marianna University School of Medicine
二元的アポトーシス制御因子シノビオリンを標的としたがん研究
- Principal Investigator
  
  NAKAJIMA Toshihiro
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Choju Medical Institute, Fukushimura Hospital.
シノビオリンの二方向性シグナル制御の生物学的意義
- Principal Investigator
  
  中島利博
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Choju Medical Institute, Fukushimura Hospital.
Integrated study on implication of Synoviolin in multiprocesses of rheumatoid arthritis.
- Principal Investigator
  
  NAKAJIMA Toshihiro
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Tokyo Medical University
  Choju Medical Institute, Fukushimura Hospital.
The development of a novel molecular targeting therapeutic intervention in HTLV-1-associated myelopathy(HAM)Principal Investigator
- Principal Investigator
  
  YAMANO Yoshihisa
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  St.Marianna University School of Medicine

[Book] 神経関連感染症　最新医学　別冊2014
- Author(s)
  山野嘉久.
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-25461294
[Book] すべての内科医が知っておきたい神経疾患の診かた、考え方とその対応2013
- Author(s)
  山野嘉久
- Total Pages
  373
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22590943
[Book] HAM(HTLV-1 関連脊髄症). すべての内科医が知っておきたい神経疾患の診かた、考え方とその対応2013
- Author(s)
  山野嘉久
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-22590943
[Book] Host Immune System Abnormalities Among Patients with HumanT-Lymphotropic Virus Type 1 (HTLV-1)-Associated Disorders.2011
- Author(s)
  Sato T., Araya N., Yagishita N., Ando H., Yamano Y.
- Publisher
  T-Cell Leukemia
- Data Source
  KAKENHI-PROJECT-22590943
[Book] HTLV-1 infected CD4+CD25+CCR4+T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease. Immunologic signatures of Rejection2010
- Author(s)
  Yamano Y., Jacobson S.(Eds : Marincola, F.M.Wang E.
- Publisher
  Springer Science
- Data Source
  KAKENHI-PROJECT-22590943
[Book] HTLV-1 infected CD4+CD25+CCR4+T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease.2010
- Author(s)
  Yamano Y. and Jacobson S.
- Publisher
  Immunologic Signatures of Rejection, 1st Edition
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] HTLV-1関連脊髄症（HAM）に対する新規治療法.2019
- Author(s)
  山野嘉久.
- Journal Title
  
  Annual Review 神経
  
  Volume: 2019 Pages: 149-154
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Risk of Human T-Cell Leukemia Virus Type 1 Infection in Kidney Transplantation2019
- Author(s)
  Yamauchi J, Yamano Y, Yuzawa K.
- Journal Title
  
  The New England Journal of Medicine
  
  Volume: 380(3) Pages: 296-298
- DOI
  10.1056/nejmc1809779
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-17H02462
[Journal Article] Targeting human T‐lymphotropic virus type 1‐infected cells with an anti‐C‐C chemokine receptor 4 antibody in T‐lymphotropic virus type 1‐associated myelopathy.2018
- Author(s)
  Sato T, Yamano Y.
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 9(3) Pages: 153-154
- DOI
  10.1111/cen3.12467
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16K09702
[Journal Article] HTLV-1関連脊髄症―病態解明と治療の最新情報はじめに.2018
- Author(s)
  山野嘉久.
- Journal Title
  
  医学のあゆみ
  
  Volume: 267(10) Pages: 735-735
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Proposal of Classification Criteria for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Disease Activity.2018
- Author(s)
  Sato T, Yagishita N, Tamaki K, Inoue E, Hasegawa D, Nagasaka M, Suzuki H, Araya N, Ariella Coler-Reilly, Hasegawa Y, Tsuboi Y, Takata A, Yamano Y.
- Journal Title
  
  Front Microbiol
  
  Volume: 25(9) Pages: 1651-1651
- DOI
  10.3389/fmicb.2018.01651
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16K09701
[Journal Article] HTLV-1関連脊髄症.2018
- Author(s)
  山野嘉久.
- Journal Title
  
  感染症
  
  Volume: 48(6) Pages: 25-28
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] HTLV-1関連脊髄症（HAM）の病態・診断・治療.2018
- Author(s)
  山野嘉久, 山内淳司, 新谷奈津美, 八木下尚子, 佐藤知雄.
- Journal Title
  
  神経内科
  
  Volume: 89(3) Pages: 297-303
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation.2018
- Author(s)
  Hirano M, Jimbo K, Ogawa M, Ochi K, Makiyama J, Kawamata T, Yokoyama K, Tanaka T, Inamoto Y, Yamano Y, Fukuda T, Uchimaru K, Imai Y, Tojo A.
- Journal Title
  
  Bone Marrow Transplant
  
  Volume: 53 Issue: 11 Pages: 1470-1473
- DOI
  10.1038/s41409-018-0202-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H06277
[Journal Article] Organ Involvement Pattern Suggests Subgroups within Relapsing Polychondritis.2018
- Author(s)
  Shimizu J, Yamano Y, Yudoh K, Suzuki N.
- Journal Title
  
  Arthritis Rheumatol.
  
  Volume: 70 Pages: 148-149
- DOI
  10.1002/art.40330
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K10009, KAKENHI-PROJECT-16H05323
[Journal Article] Value assignment of the reference material for human T-cell leukemia virus type l quantitative PCR in Japan2018
- Author(s)
  Madoka Kuramitsu, Kaoru Uchimaru, Yasuko Sagara, Toshiki Watanabe, Isao Hamaguchi, et al.
- Journal Title
  
  Microbiol Immunol
  
  Volume: 62 Issue: 10 Pages: 673-676
- DOI
  10.1111/1348-0421.12644
- NAID
  40021702629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-16H06277
[Journal Article] The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation2018
- Author(s)
  Kawano N, Yoshida S, Kawano S, Kuriyama T, Tahara Y, Toyofuku A, Manabe T, Doi A, Terasaka S, Yamashita K, Ueda Y, Ochiai H, Marutsuka K, Yamano Y, Shimoda K, Kikuchi I.
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 58(3) Issue: 3 Pages: 107-121
- DOI
  10.3960/jslrt.18011
- NAID
  130007484712
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Mogamulizumab (Anti-CCR4) in HTLV-1-Associated myelopathy2018
- Author(s)
  Sato T, Coler-Reilly A, Yagishita N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y, Yamano Y
- Journal Title
  
  New Engl J Med,
  
  Volume: 378(6) Pages: 529-538
- DOI
  10.1056/nejmoa1704827
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09701, KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-17K19610, KAKENHI-PROJECT-16H05336, KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H06277
[Journal Article] 希少難病HAMの患者レジストリを活用した治療薬開発への取り組みと展望.2018
- Author(s)
  八木下尚子, 山野嘉久.
- Journal Title
  
  Jpn Pharmacol Ther（薬理と治療）
  
  Volume: 46(7) Pages: 1113-1116
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] HTLV-1関連脊髄症の診断と治療.2017
- Author(s)
  山野嘉久.
- Journal Title
  
  日本内科学会雑誌
  
  Volume: 106（7） Pages: 1404-1409
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] The Impact of a Humanized CCR4 Antibody (Mogamulizumab) on Patients with Aggressive-Type Adult T-Cell Leukemia-Lymphoma Treated with Allogeneic Hematopoietic Stem Cell Transplantation2017
- Author(s)
  Kawano N, Kuriyama T, Yoshida S, Kawano S, Yamano Y, Marutsuka K, Minato S, Yamashita K, Ochiai H, Shimoda K, Ishikawa F, Kikuchi I.
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 56(3) Issue: 3 Pages: 135-144
- DOI
  10.3960/jslrt.56.135
- NAID
  130005465222
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] HAM患者レジストリ「HAMねっと」によるリアルワールドデータの活用.2017
- Author(s)
  八木下尚子, 山野嘉久.
- Journal Title
  
  PHARMSTAGE
  
  Volume: 17(6) Pages: 19-22
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] IL-10-mediated signals act as a switch for lymphoproliferation in Human T-cell leukemia virus type-1 infection by activating the STAT3 and IRF4 pathways.2017
- Author(s)
  Sawada L, Nagano Y, Hasegawa A, Kanai H, Nogami K, Ito S, Sato T, Yamano Y, Tanaka Y, Masuda T, Kannagi M.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13(9)
- DOI
  10.1371/journal.ppat.1006597
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-16H05323
[Journal Article] Treatment of rheumatoid arthritis with biologics may exacerbate HTLV-1-associated conditions: A case report.2017
- Author(s)
  Terada Y, Kamoi K, Ohno-Matsui K, Miyata K, Yamano C, Coler-Reilly A, Yamano Y.
- Journal Title
  
  Medicine (Baltimore).
  
  Volume: 96(6)
- DOI
  10.1097/md.0000000000006021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] HTLV-1関連脊髄症（HAM）の分子病態と治療.2017
- Author(s)
  新谷奈津美, 山野嘉久.
- Journal Title
  
  血液内科
  
  Volume: 74(3) Pages: 373-379
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] HTLV-1関連脊髄症に対するヒト化抗CCR4抗体療法開発の背景.2017
- Author(s)
  山野嘉久.
- Journal Title
  
  神経治療学
  
  Volume: 34（4） Pages: 453-457
- NAID
  130006386692
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Nation-wide epidemiological study of Japanese patients with rare viral myelopathy using novel registration system (HAM-net).2016
- Author(s)
  Coler-Reilly ALG, Yagishita N, Suzuki H, Sato T, Araya N, Inoue E, Takata A, Yamano Y.
- Journal Title
  
  Orphanet Journal of Rare Diseases
  
  Volume: 11(1) Pages: 69-69
- DOI
  10.1186/s13023-016-0451-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16K09701, KAKENHI-PROJECT-16K09702
[Journal Article] HTLV-1 induces a Th1-like state in CD4+ CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP2016
- Author(s)
  Yamano Y, Coler-Reilly A
- Journal Title
  
  J Neuroimmunol
  
  Volume: 304 Pages: 51-55
- DOI
  10.1016/j.jneuroim.2016.08.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Developing novel treatments for HTLV-1-associated myelopathy (HAM) by investigating molecular pathomechanisms2016
- Author(s)
  新谷奈津美, 佐藤知雄, アリエラ・コラライリー, 八木下尚子, 山野嘉久.
- Journal Title
  
  Japanese Journal of Clinical Immunology
  
  Volume: 39(3) Issue: 3 Pages: 207-212
- DOI
  10.2177/jsci.39.207
- NAID
  130005157506
- ISSN
  0911-4300, 1349-7413
- Language
  Japanese
- Open Access
- Data Source
  KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16K09701, KAKENHI-PROJECT-16K09702
[Journal Article] HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors.2016
- Author(s)
  Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M.
- Journal Title
  
  Journal of Neurovirology
  
  Volume: in press Pages: 416-430
- DOI
  10.1007/s13365-015-0407-2
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K09345
[Journal Article] HTLV-12016
- Author(s)
  山野嘉久, 齋藤滋.
- Journal Title
  
  産科と婦人科
  
  Volume: 83(9) Pages: 1021-1026
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] HTLV-1関連脊髄症の病態に基づいた疾患修飾薬の開発.2016
- Author(s)
  山野嘉久
- Journal Title
  
  Modern Physician
  
  Volume: 36(7) Pages: 682-687
- Data Source
  KAKENHI-PROJECT-16H05323
[Journal Article] Mogamulizumab, an anti-CCR4 antibody, targets human T-lymphotropic virus type 1-infected CD8+ and CD4+ T cells to treat associated myelopathy2015
- Author(s)
  Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Ando H, Kunitomo Y, Takahashi K, Tanaka Y, Shibagaki Y, Nishioka K, Nakajima T, Hasegawa Y, Utsunomiya A, Kimura K, Yamano Y.
- Journal Title
  
  J Infect Dis
  
  Volume: 211 Issue: 2 Pages: 238-248
- DOI
  10.1093/infdis/jiu438
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-221S0001
[Journal Article] HTLV-1関連脊髄症（HAM）－分子病態解明による治療薬開発の新展開.2015
- Author(s)
  山野嘉久.
- Journal Title
  
  医学のあゆみ
  
  Volume: 255(5) Pages: 485-490
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] The E3 ligase synoviolin controls body weight and mitochondrial biogenesis through negative regulation of PGC-1β2015
- Author(s)
  Fujita H, Yagishita N, Aratani S, Saito-Fujita T, Morota S, Yamano Y, Hansson MJ, Inazu M, Kokuba H, Sudo K, Sato E, Kawahara K, Nakajima F, Hasegawa D, Higuchi I, Sato T, Araya N, Usui C, Nishioka K, Nakatani Y, Maruyama I, Usui M, Hara N, Uchino H, Elmer E, Nishioka K, Nakajima T.
- Journal Title
  
  EMBO J
  
  Volume: 34 Pages: 1042-1042
- DOI
  10.15252/embj.201489897
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-26293387, KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-26670793, KAKENHI-PROJECT-26461478, KAKENHI-PROJECT-26461961, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-25860726, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-15K15667, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-26293385
[Journal Article] A plasma diagnostic model of human T cell leukemia virus-1 associated myelopathy2015
- Author(s)
  Ishihara M, Araya N, Sato T, Saichi N, Fujii R, Yamano Y, Sugano S, Ueda K.
- Journal Title
  
  Annals of Clinical and Translational Neurology
  
  Volume: 2(3) Pages: 231-240
- DOI
  10.1002/acn3.169
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-26710007
[Journal Article] HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis.2015
- Author(s)
  Bangham C, Araujo A, Yamano Y & Taylor G.
- Journal Title
  
  Nature Reviews Disease Primers
  
  Volume: 1
- DOI
  10.1038/nrdp.2015.12
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] How does human T-lymphotropic virus type 1 cause central nervous system disease? The importance of cross-talk between infected T cells and astrocytes.2015
- Author(s)
  Kenichi Kaida
- Journal Title
  
  Clin Exp Neuroimmunol
  
  Volume: 6 Pages: 387-394
- DOI
  10.1111/cen3.12256
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24591282, KAKENHI-PROJECT-25461294
[Journal Article] 免疫性神経疾患－基礎・臨床研究の最新知見－.2015
- Author(s)
  山野嘉久、新谷奈津美、八木下尚子、佐藤知雄.
- Journal Title
  
  日本臨牀
  
  Volume: 73（7） Pages: 546-553
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] Standardization of Quantitative PCR for Human T-cell Leukemia Virus Type 1 in Japan: A Collaborative Study.2015
- Author(s)
  Kuramitsu M, Okuma K, Yamochi T. et al
- Journal Title
  
  J Clin Microbiol
  
  Volume: 53 Pages: 3485-3491
- DOI
  10.1128/jcm.01628-15
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-25461440, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294
[Journal Article] Neurological involvement of relapsing polychondritis in Japan: An epidemiological study.2014
- Author(s)
  Suzuki N, Shimizu J, Oka H, Yamano Y, Yudoh K.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 34(4) Pages: 206-208
- NAID
  130004943867
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1関連脊髄症（HAM）に対する分子標的治療薬開発の現状と将来.2014
- Author(s)
  新谷奈津美, 山野嘉久.
- Journal Title
  
  血液内科
  
  Volume: 68（1） Pages: 30-35
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] Positive feedback loop via astrocytes causes chronic inflammation in human T lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.2014
- Author(s)
  Coler-Reilly A, Ando H, Yamano Y.
- Journal Title
  
  Clinical and Experimental Neuroimmunology
  
  Volume: 5 Pages: 108-109
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] A case of post-transplant adult T-cell leukemia/lymphoma presenting myelopathy similar to but distinct from human T-cell leukemia virus type I (HTLV- I)-associated myelopathy.2014
- Author(s)
  Kawamata T, Ohno N, Sato K, Kobayashi M, Jo N, Yuji K, Tanosaki R, Yamano Y, Tojo A, Uchimaru K.
- Journal Title
  
  SpringerPlus
  
  Volume: 3 Pages: 581-581
- DOI
  10.1186/2193-1801-3-581
- Open Access
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] 希少な慢性進行性の神経難病HAMにおける治療有効性評価モデルの探索.2014
- Author(s)
  山野嘉久.
- Journal Title
  
  臨床評価　別冊
  
  Volume: 41(3) Pages: 504-508
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] 気道病変を有する再発性多発軟骨炎に対するチオトロピウムの効果.2014
- Author(s)
  半田寛,　薄場彩乃,　岡本真理子,　井上哲兵,　延山誠一,　井上健男,　峯下昌道,　山野嘉久,　宮澤輝臣.
- Journal Title
  
  聖マリアンナ医科大学雑誌
  
  Volume: 41(4) Pages: 315-321
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1 induces a Thl-like state in CD4+CCR4+T cells2014
- Author(s)
  Araya N, Sato T, Ando H, Tomaru U, Yoshida M, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Nakajima T, Nishioka K, Utsunomiya A, Jacobson S, Yamano Y.
- Journal Title
  
  J Clin Invest
  
  Volume: 124 Issue: 8 Pages: 3431-3442
- DOI
  10.1172/jci75250
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24592282, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25460489, KAKENHI-PROJECT-25461181, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-221S0001
[Journal Article] HTLV-1関連脊髄症（HAM）2014
- Author(s)
  山野嘉久
- Journal Title
  
  別冊日本臨牀
  
  Volume: 30 Pages: 153-156
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1関連脊髄症（HAM）の分子病態に基づく治療戦略.2014
- Author(s)
  山野嘉久.
- Journal Title
  
  細胞
  
  Volume: 46(6) Pages: 258-261
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1の神経障害.2014
- Author(s)
  山野嘉久.
- Journal Title
  
  内科
  
  Volume: 113(6) Pages: 1431-1431
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1 関連脊髄症(HAM)2013
- Author(s)
  山野嘉久、佐藤知雄、宇都宮與
- Journal Title
  
  日本臨牀
  
  Volume: (in press)
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] 慢性型ATLの自然寛解後にHTLV-1関連脊髄症を発症した症例.2013
- Author(s)
  宇都宮與, 山野嘉久.
- Journal Title
  
  血液フロンティア
  
  Volume: 23(3) Pages: 5-10
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] 白血病　非定型白血病および特殊型　HTLV-1関連脊髄症（HAM）.2013
- Author(s)
  山野嘉久、佐藤知雄、宇都宮與.
- Journal Title
  
  別冊日本臨牀　新領域別症候群シリーズ　血液症候群（第2版）
  
  Volume: 23(III) Pages: 195-199
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia.2013
- Author(s)
  Ishihara M., Araya N., Sato T., et al.
- Journal Title
  
  Blood
  
  Volume: 121(21) Pages: 4340-4347
- DOI
  10.1182/blood-2012-08-446922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22680064, KAKENHI-PROJECT-23701090, KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-25830126
[Journal Article] Potential contribution of a novel Tax epitope-specific CD4+ T cells to graft-versus-Tax effects in adult T-cell leukemia patients after allogeneic hematopoietic stem cell transplantation.2013
- Author(s)
  Tamai Y., Hasegawa A., Takamori A., et al.
- Journal Title
  
  J. Immunol
  
  Volume: 190 Pages: 4382-4392
- DOI
  10.4049/jimmunol.1202971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-23591414, KAKENHI-PROJECT-25461294, KAKENHI-PROJECT-25461453, KAKENHI-PROJECT-221S0001
[Journal Article] CSF CXCL10, CXCL9, and Neopterin as Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis.2013
- Author(s)
  Sato T., Coler-Reilly A., Utsunomiya A., Araya N., Yagishita N., Ando H., Yamauchi J., Inoue E., Ueno T., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Izumo S., Yamano Y.
- Journal Title
  
  PLoS Negl Trop Dis.
  
  Volume: 7(10)
- DOI
  10.1371/journal.pntd.0002479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294
[Journal Article] Positive feedback loop via astrocytes causes chronic inflammation in virus-associated myelopathy.2013
- Author(s)
  Ando H., Sato T., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Shimizu Y., Yudoh K., Hasegawa Y., Nishioka K., Nakajima T., Jacobson S., Yamano Y.
- Journal Title
  
  Brain.
  
  Volume: 136(Pt9) Pages: 2876-2887
- DOI
  10.1093/brain/awt183
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24790898, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-25460489, KAKENHI-PROJECT-25461181, KAKENHI-PROJECT-25461293, KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1関連脊髄症（HAM）の病態・治療とバイオマーカー2013
- Author(s)
  山野嘉久、他
- Journal Title
  
  日本臨牀
  
  Volume: 71（5） Pages: 870-875
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] HTLV-1 関連脊髄症(HAM)の病態・治療とバイオマーカー2013
- Author(s)
  山野嘉久、佐藤知雄
- Journal Title
  
  日本臨牀
  
  Volume: 71(5) Pages: 870-875
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] HTLV-1関連脊髄症（HAM）の病態・治療とバイオマーカー2013
- Author(s)
  山野嘉久、佐藤知雄
- Journal Title
  
  日本臨牀
  
  Volume: 71（5） Pages: 870-875
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1関連脊髄症（HAM）2013
- Author(s)
  山野嘉久、他
- Journal Title
  
  日本臨牀
  
  Volume: in press
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Human T-lymphotropic virus type 1感染者における腎移植の影響.2013
- Author(s)
  山内淳司、八木下尚子、安藤仁、佐藤知雄、新谷奈津美、Ariella, Coler-Reilly、今井直彦、中澤龍斗、佐々木秀郎、柴垣有吾、安田隆、力石辰也、木村健二郎、山野嘉久.
- Journal Title
  
  日本臨床腎移植学会雑誌
  
  Volume: 1(1) Pages: 55-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461294
[Journal Article] HTLV-1 関連脊髄症(HAM)の治療法を確立していくために-その現状と展望-.2012
- Author(s)
  山野嘉久、佐藤知雄、安藤仁、新谷奈津美、八木下尚子
- Journal Title
  
  日本臨牀
  
  Volume: 70(4) Pages: 705-713
- NAID
  40019238663
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation- Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012
- Author(s)
  Fujii R, Komatsu R, Sato T, Yagishita N, Aratani S, Araya N, Nishikawa H, Yamano Y, Yudoh K,Beppu M, Nishioka K, Nakajima T
- Journal Title
  
  J St. Marianna Univ.
  
  Volume: 40(2) Pages: 51-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591088
[Journal Article] HTLV-1関連脊髄症(HAM)の治療法を確立していくために-その現状と展望-2012
- Author(s)
  山野嘉久, 他
- Journal Title
  
  日本臨牀
  
  Volume: 70(4) Pages: 705-713
- NAID
  40019238663
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Clinical pathophysiology of humanT-lymphotropic virus-type1-associatedmyelopathy/tropical spasticparaparesis.2012
- Author(s)
  Yamano Y., Sato T.
- Journal Title
  
  Frontiers in Virology
  
  Volume: 3(389) Pages: 1-10
- DOI
  10.3389/fmicb.2012.00389
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] RING finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis2012
- Author(s)
  Yagishita N, Aratani S, Leach C, Amano T, Yamano Y, Nakatani K, Nishioka K, Nakajima T
- Journal Title
  
  Int J Mol Med
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] HTLV-1 関連脊髄症(HAM)の治療法を確立していくために-その現状と展望-2012
- Author(s)
  山野嘉久、佐藤知雄、安藤仁、新谷奈津美、八木下尚子
- Journal Title
  
  日本臨牀
  
  Volume: 70(4) Pages: 705-713
- NAID
  40019238663
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] HTLV-1関連脊髄症（HAM）の治療法を確立していくために―その現状と展望―2012
- Author(s)
  山野嘉久、他
- Journal Title
  
  日本臨牀
  
  Volume: 70(4) Pages: 705-713
- NAID
  40019238663
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Advantage of higher-avidity CTL specific for Tax against human T-lymphotropic virus-1 infected cells and tumors2011
- Author(s)
  Kitazono T., Araya N., Yamano Y.,et al.
- Journal Title
  
  Cell Immunol
  
  Volume: 272(1) Pages: 11-17
- DOI
  10.1016/j.cellimm.2011.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22790833, KAKENHI-PROJECT-221S0001
[Journal Article] HTLV-1キャリアー,HTLV-1-associated myelopathy (HAM)患者診療の現状と問題点2011
- Author(s)
  山野嘉久
- Journal Title
  
  血液内科
  
  Volume: 63(1) Pages: 81-86
- NAID
  40019064410
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Overexpression of SPACIA1/SAAL1, a new gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans.2011
- Author(s)
  佐藤知雄、中島利博, 他11名
- Journal Title
  
  Arthritis Rheum.
  
  Volume: 63 Pages: 3833-3842
- DOI
  10.1002/art.30617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22591088, KAKENHI-PROJECT-22790833, KAKENHI-PROJECT-23659176
[Journal Article] Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type1-associated neurological disease.2011
- Author(s)
  Araya N, Arimura H, Kawahara K, Yagishita N, Ishida J, Fujii R, Aratani S, Fujita H, Sato T, Yamano Y, Higuchi I, Osame M, Nishioka K, Fukamizu A, Arimura K, Maruyama I, Nakajima T.
- Journal Title
  
  Antiviral Therapy
  
  Volume: 24 Pages: 605-611
- DOI
  10.3892/ijmm_00000271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-23659176
[Journal Article] Prostaglandin EP2receptor signalling inhibits the expression of matrix metalloproteinase13 in human osteoarthritic chondrocytes.2011
- Author(s)
  Sato T, Konomi K, Fujii R, Aono H, Aratani S, Yagishita N, Araya N, Yudoh K, Beppu M, Yamano Y, Nishioka K, Nakajima T
- Journal Title
  
  Annals of the Rheumatic Diseases
  
  Volume: 70 Pages: 221-22
- DOI
  10.1136/ard.2009.118620
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22790833, KAKENHI-PROJECT-23659176
[Journal Article] HAM専門外来の取り組み2011
- Author(s)
  山野嘉久, 他
- Journal Title
  
  神経内科
  
  Volume: 75(4) Pages: 387-392
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Human T-lymphotropic virus type 1 (HTLV-1) and innate immunity2011
- Author(s)
  Sato T., Azakami K., Ando H., Araya N., Yamano Y.
- Journal Title
  
  Inflammation and Regeneration
  
  Volume: 31(1) Pages: 110-115
- NAID
  130004943766
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type1-associated neurological disease2011
- Author(s)
  Araya N, Takahashi K, Sato T, Nakamura T, Sawa C, Hasegawa D, Ando H, Aratani S, Yagishita N, Fujii R, Oka H, Nishioka K, Nakajima T, Mori N, Yamano Y
- Journal Title
  
  Antivir Ther
  
  Volume: 16 Pages: 89-98
- URL
  http://www.intmedpress.com/serveFile.cfm?sUID=eda7bacc-605e-4dd6-b2aa-f62abc29e554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Prevalence of Group A b-Hemolytic Streptococcus Among Children with Tonsillopharyngitis in Kyrgyzstan : The Difficulty of Diagnostics and Therapy2010
- Author(s)
  Omurzakova NA, Yamano Y, Saatova GM, Alybaeva MS, Nishioka K, Nakajima T
- Journal Title
  
  Open Rheumatol J
  
  Volume: 4 Pages: 39-46
- DOI
  10.2174/1874312901004010039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] The contribution of Asian researchers to the field of rheumatology.2010
- Author(s)
  Yamano Y., Nishioka K.
- Journal Title
  
  Nat Rev Rheumatol
  
  Volume: 6(2) Pages: 106-111
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Inter-andintra-laboratory Variability in HTLV-1Proviral Load Quantification UsingReal-Time Polymerase Chain ReactionAssays: A Multi-Center Study.2010
- Author(s)
  Kamihira S., Yamano Y., Iwanaga M., et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 101(11) Pages: 2361-2367
- DOI
  10.1111/j.1349-7006.2010.01720.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] E3 Ubiquitin Ligase Synoviolin Is Involved in Liver Fibrogenesis2010
- Author(s)
  Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koike J, Tadokoro M, Suzuki N, Nagata K, Senoo H, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T
- Journal Title
  
  PLoS One
  
  Volume: 5
- DOI
  10.1371/journal.pone.0013590
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22790833
[Journal Article] E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis2010
- Author(s)
  Hasegawa D, Fujii R, Yagishita N, Matsumoto N, Aratani S, Izumi T, Azakami K, Nakazawa M, Fujita H, Sato T, Araya N, Koide J, Tadokoro M, Suzuki N, Friedman SL, Nishioka K, Yamano Y, Itoh F, Nakajima T
- Journal Title
  
  PLoS One 5(10)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Neuroimmunity of HTLV-I Infection.2010
- Author(s)
  Matsuura E., Yamano Y., Jacobson S.
- Journal Title
  
  J Neuroimmune Pharmacol
  
  Volume: 5(3) Pages: 310-325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590943
[Journal Article] Increased Prevalence of Group A b-hemolytic Streptococcus Among Ethnic Population in Kyrgyzstan Defined by Rapid Antigen Detection Test2009
- Author(s)
  中島利博、八木下尚子、上昌広、丸山征郎、山野嘉久, 他12名
- Journal Title
  
  Molecular Medicine Reports 1(6)
  
  Pages: 869-874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Increased Prevalence of Group A b-hemolnytic Streptococcus Among Ethnic Population in Kyrgyzstan Defined by Rapid Antigen Detection Test.2009
- Author(s)
  中島利博、八木下尚子、丸山征郎、山野嘉久他13名
- Journal Title
  
  Molecular Medicine Reports 1(6)
  
  Pages: 869-874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059033
[Journal Article] Abnormally high levels of virus-infected IFN-γ+CCR4+CD4+CD25+ Tcells in a retrovirus-associated neuroinflammatory disorder.2009
- Author(s)
  Yamano Yoshihisa
- Journal Title
  
  PLoS One 4e
  
  Pages: 61517-61517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013045
[Journal Article] Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha.2009
- Author(s)
  Izumi T, Fujii R, Izumi T, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S, Nakajima T
- Journal Title
  
  Arthritis Rheum. 60(1)
  
  Pages: 63-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Abnormally high levels of virus-infected IFN-_Y+CCR4+CD4+CD25+Tcells in a retrovirus-associated neuroinflammatory disorder.2009
- Author(s)
  Yamano Yoshihisa
- Journal Title
  
  PLoS One 4e
  
  Pages: 61517-61517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Abnormally high levels of virus-infected IFN-γ+CCR4+CD4+CD25+ Tcells in a retrovirus-associated neuroinflammatory disorder.2009
- Author(s)
  Yamano Yoshihisa
- Journal Title
  
  PLoS One 4e
  
  Pages: 61517-61517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059033
[Journal Article] Abnormally high levels of virusinfected IFN-gamma+CCR4+CD4+CD25+T cells in a retrovirus-associated neuroinflammatory disorder2009
- Author(s)
  Yamano Y, Araya N, Sato T, Utsunomiya A, Azakami K, Hasegawa D, Izumi T, Fujita H, Aratani S, Yagishita N, Fujii R, Nishioka K, Jacobson S, Nakajima T
- Journal Title
  
  PLoS One
  
  Volume: 4
- DOI
  10.1371/journal.pone.0006517
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid beta-protein2009
- Author(s)
  Maeda T, Marutani T, Zou K, Araki W, Tanabe C, Yagishita N, Yamano Y, Amano T, Michikawa M, Nakajima T, Komano H
- Journal Title
  
  FEBS J
  
  Volume: 276 Pages: 5832-5840
- DOI
  10.1111/j.1742-4658.2009.07264.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Impaired Tax-specific T-cell responses with insufficient control of HTLV-1 in a subgroup of individuals at asymptomatic and smoldering stages2009
- Author(s)
  Shimizu Y., Takamori A., Utsunomiya A., Kurimura M., Yamano Y. , et.al.
- Journal Title
  
  Cancer Sci 100(3)
  
  Pages: 481-489
- NAID
  10025143429
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591015
[Journal Article] Activation of Synoviolin Promoter in Rheumatoid Synovial Cells by a Novel Transcription Complex of Interleukin Enhancer Binding Factor 3 and GA Binding Protein2009
- Author(s)
  Izumi T., Fujii R., Izumi T., Nakazawa M., Yagishita N., Tsuchimochi K., Yamano Y, et.al.
- Journal Title
  
  Arthritis Rheum 60(1)
  
  Pages: 63-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591015
[Journal Article] Rheumatologic services in Central Asian countries : current state of development of rheumatology in Central Asia2009
- Author(s)
  Omurzakova NA, Yamano Y, Saatova GM, Shukurova SM, Mirzakhanova MI, Kydyralieva RB, Jumagulova AS, Mirrakhimov EM, Seisenbaev Ash, Nishioka K, Nakajima T
- Journal Title
  
  Int J Rheum Dis
  
  Volume: 12 Pages: 288-292
- DOI
  10.1111/j.1756-185x.2009.01442.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Increased Prevalence of Group A b-hemolytic Streptococcus Among Ethnic Population in Kyrgyzstan Defined by Rapid Antigen Detection Test.2009
- Author(s)
  中島利博、八木下尚子、丸山征郎、山野嘉久他13名
- Journal Title
  
  Molecular Medicine Reports 1(6)
  
  Pages: 869-874
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013045
[Journal Article] Activation of synoviolin promoter in rheumatoid synovial cells by a novel transcription complex of interleukin enhancer binding factor 3 and GA binding protein alpha2009
- Author(s)
  Izumi T, Fujii R, Izumi T, Nakazawa M, Yagishita N, Tsuchimochi K, Yamano Y, Sato T, Fujita H, Aratani S, Araya N, Azakami K, Hasegawa D, Kasaoka S, Tsuruta R, Yokouti M, Ijiri K, Beppu M, Maruyama I, Nishioka K, Maekawa T, Komiya S, Nakajima T
- Journal Title
  
  Arthritis Rheum
  
  Volume: 60 Pages: 63-72
- DOI
  10.1002/art.24178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] High incidence of rheumatic fever and rheumatic heart disease in the republics of Central Asia2009
- Author(s)
  Omurzakova NA, Yamano Y, Saatova GM, Mirzakhanova MI, Shukurova SM, Kydyralieva RB, Jumagulova AS, Seisenbaev Ash, Nishioka K, Nakajima T
- Journal Title
  
  Int J Rheum Dis
  
  Volume: 12 Pages: 79-83
- DOI
  10.1111/j.1756-185x.2009.01388.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Severe loss of invariant NKT cells exhibiting anti-HTLV-1 activity in patients with HTLV-1-associated disorders2009
- Author(s)
  Azakami K, Sato T, Araya N, Utsunomiya A, Kubota R, Suzuki K, Hasegawa D, Izumi T, Fujita H, Aratani S, Fujii R, Yagishita N, Kamijuku H, Kanekura T, Seino K, Nishioka K, Nakajima T, Yamano Y
- Journal Title
  
  Blood
  
  Volume: 114 Pages: 3208-3321
- DOI
  10.1182/blood-2009-02-203042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Novel transcriptional complex of ILF3-GABP α activates synoviolin promoter in rheumatoid synovial cells2008
- Author(s)
  中島利博、八木下尚子、山野嘉久、丸山征郎他19名
- Journal Title
  
  A&R 60
  
  Pages: 63-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20013045
[Journal Article] Novel transcriptional complex of ILF3-GABP α activates synoviolin promoter in rheumatoid synovial cells2008
- Author(s)
  中島利博、八木下尚子、山野嘉久、丸山征郎他19名
- Journal Title
  
  A&R 60
  
  Pages: 63-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059033
[Journal Article] Increased prevalence of group A-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection tes2008
- Author(s)
  Omurzakova N.A., Yamano Y., Sato T., Izumi T., Azakami K. , et.al.
- Journal Title
  
  Molecular Medicine Report 1
  
  Pages: 869-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591015
[Journal Article] Increased prevalence of group Aβ-hemolytic streptococcus among an ethnic population in Kyrgyzstan detected by the rapid antigen detection test2008
- Author(s)
  Omurzakova OA, Yamano Y, Sato T, Izumi T, Azakami K, Hasegawa D, Fujii R, Yagishita N, Aratani S, Kabaeva ZS, Mirrakhimov MM, Kami M, Maruyama I, Osame M, Yokota S, Nishioka K, Nakajima T
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 1 Pages: 869-874
- DOI
  10.3892/mmr_00000043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Journal Article] Dysregulation of TGF-beta signaling and regulatory and effector T cell function in virus-induced neuroinflammatory disease2008
- Author(s)
  Grant C., Oh U., Yao K., Yamano Y., Jacobson S
- Journal Title
  
  Blood 111(12)
  
  Pages: 5601-5609
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591015
[Journal Article] Novel transcriptional complex of ILF3-GABP α activates synoviolin promoter in rheumatoid synovial cells2008
- Author(s)
  中島利博、八木下尚子、山野嘉久、丸山征郎, 他19名
- Journal Title
  
  A&R 60
  
  Pages: 63-72
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052
[Patent] HTLV-1関連脊髄症(HAM)治療又は予防剤2018
- Inventor(s)
  内丸薫,山岸誠,石崎伊純,山野嘉久
- Industrial Property Rights Holder
  内丸薫,山岸誠,石崎伊純,山野嘉久
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-135925
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H05323
[Patent] ＨＴＬＶ－１関連脊髄症を治療することに用いるための医薬組成物2017
- Inventor(s)
  荒木一司、山野嘉久、新谷奈津美
- Industrial Property Rights Holder
  荒木一司、山野嘉久、新谷奈津美
- Industrial Property Rights Type
  特許
- Filing Date
  2017
- Data Source
  KAKENHI-PROJECT-16H05323
[Patent] ＨＴＬＶ－１関連脊髄症を治療することに用いるための医薬組成物2017
- Inventor(s)
  荒木一司、山野嘉久、新谷奈津美
- Industrial Property Rights Holder
  荒木一司、山野嘉久、新谷奈津美
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2017-007887
- Filing Date
  2017-01-19
- Data Source
  KAKENHI-PROJECT-16H05323
[Patent] Production method of gamma delta T cell and use thereof2015
- Inventor(s)
  Yamano Y, Seino K, Muto M.
- Industrial Property Rights Holder
  Yamano Y, Seino K, Muto M.
- Industrial Property Rights Type
  特許
- Filing Date
  2015-10-13
- Overseas
- Data Source
  KAKENHI-PROJECT-25461294
[Patent] ヒトTリンパ好性ウイルス－１（HTLV-1）関連脊髄症（HAM/TSP）の検査方法、及び検査用キット2014
- Inventor(s)
  山野嘉久、植田幸嗣、石原誠人.
- Industrial Property Rights Holder
  山野嘉久、植田幸嗣、石原誠人.
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-226719
- Filing Date
  2014-11-07
- Data Source
  KAKENHI-PROJECT-25461294
[Patent] γδＴ細胞の製造方法および医薬2014
- Inventor(s)
  山野嘉久、清野研一郎、武藤真人.
- Industrial Property Rights Holder
  山野嘉久、清野研一郎、武藤真人.
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2014-209669
- Filing Date
  2014-10-14
- Data Source
  KAKENHI-PROJECT-25461294
[Patent] A Therapeutic Method And Medicament For HTLV-1 Associated Myelopathy(HAM)2012
- Inventor(s)
  Yoshihisa Yamano
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Filing Date
  2012-07-06
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] A Therapeutic Method And Medicament For HTLV-1 Associated Myelopathy(HAM)2012
- Inventor(s)
  Yoshihisa Yamano
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Rights Type
  特許
- Filing Date
  2012-07-06
- Overseas
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] ヒトTリンパ球向性ウイルスI型関連疾患検出用ポリペプチドとその利用2012
- Inventor(s)
  植田幸嗣、石原誠人、山野嘉久
- Industrial Property Rights Holder
  理化学研究所・聖マリアンナ医科大学
- Industrial Property Number
  2012-189318
- Filing Date
  2012-08-29
- Overseas
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] HTLV-1関連脊髄症を治療または予防するための医薬および前記医薬を用いた抗体療法の治療効果の確認方法2011
- Inventor(s)
  山野嘉久、安藤仁、佐藤知雄
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Filing Date
  2011-12-07
- Overseas
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] HTLV-1関連脊髄症を治療または予防するための医薬および前記医薬を用いた抗体療法の治療効果の確認方法2011
- Inventor(s)
  山野嘉久, 他
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Number
  2011-268019
- Filing Date
  2011-12-07
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] γδT細胞の製造方法および医薬2010
- Inventor(s)
  山野嘉久、清野研一郎
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Number
  2010-240868
- Filing Date
  2010-10-27
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] γδT細胞の製造方法および医薬2010
- Inventor(s)
  山野嘉久、清野研一郎
- Industrial Property Rights Holder
  聖マリアンナ医科大学・メディネット(株)
- Industrial Property Number
  2010-240868
- Filing Date
  2010-10-27
- Overseas
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] Diagnostic Agent for Fibromyalgia, Method For Diagnosingfibromyalgia and Medicament for Fibromyalgia.2010
- Inventor(s)
  Yoshihisa Yamano, Kusuki Nishioka.
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Filing Date
  2010-10-08
- Overseas
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] HTLV-I関連脊髄症の予防及び/又は治療のための医薬2010
- Inventor(s)
  山野嘉久、佐藤知雄、新谷奈津美
- Industrial Property Rights Holder
  聖マリアンナ医科大学(有)ケムフィズ
- Industrial Property Number
  2010-094641
- Filing Date
  2010-04-16
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] HTLV-I 関連脊髄症の予防及び/又は治療のための医薬2010
- Inventor(s)
  山野嘉久、佐藤知雄、新谷奈津美
- Industrial Property Rights Holder
  聖マリアンナ医科大学・乙卯研究所
- Industrial Property Number
  2010-094641
- Filing Date
  2010-04-16
- Overseas
- Data Source
  KAKENHI-PROJECT-22590943
[Patent] HTLV-I関連脊髄症を治療または予防するための医薬、およびHTLV-I関連脊髄症の患者に対する抗体療法の効果を予測する方法2008
- Inventor(s)
  山野嘉久、新谷奈津美
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Number
  2008-027451
- Filing Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19591015
[Patent] 自己免疫疾患の病因細胞の分離方法および自己免疫疾患の診断補助方法2008
- Inventor(s)
  山野嘉久
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Number
  2008-180580
- Filing Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19591015
[Patent] 自己免疫疾患の病因細胞の分離方法および自己免疫疾患の診断補助方法2008
- Inventor(s)
  山野嘉久
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Number
  2008-018058
- Filing Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19591015
[Patent] HTLV-I関連脊髄症を治療または予防するための医薬、およびHTLV-I関連脊髄症の患者に対する抗体療法の効果を予測する方法2008
- Inventor(s)
  山野嘉久, 新谷奈津美
- Industrial Property Rights Holder
  聖マリアンナ医科大学
- Industrial Property Number
  2008-274514
- Filing Date
  2008-10-24
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] 神経難病HTLV-1関連脊髄症(HAM)の患者が支える研究と創薬.2019
- Author(s)
  山野嘉久
- Organizer
  第92回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMにおける分子標的療法.2018
- Author(s)
  山野嘉久.
- Organizer
  第30回日本神経免疫学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAM治療薬としての抗CCR4抗体製剤（モガムリズマブ）.2018
- Author(s)
  佐藤知雄、八木下尚子、新谷奈津美、井上永介、古田梨愛、渡邉俊樹、内丸薫、松岡雅雄、松本直樹、長谷川泰弘、山野嘉久.
- Organizer
  第23回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HTLV-1関連疾患の発症メカニズムにおけるJAK-STAT経路の機能的意義の検討2018
- Author(s)
  石崎伊純、山岸誠、志賀遥菜、新谷奈津美、宇都宮與、中村龍文、田中勇悦、山野嘉久、渡邉俊樹、内丸薫
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＴＬＶ-1母子感染予防対策について.2018
- Author(s)
  山野嘉久.
- Organizer
  平成29年度神奈川県母子保健対策検討委員会.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMの病態に基づく治療薬開発.2018
- Author(s)
  山野嘉久.
- Organizer
  第5回日本HTLV-1学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Recent progress of therapeutic strategy for HTLV-1-associated myelopathy (HAM/TSP).2018
- Author(s)
  Yamano Y.
- Organizer
  The 14th International Congress of Neuroimmunology (ISNI 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAM患者に対する抗CCR4抗体製剤（モガムリズマブ）の安全性と有効性.2018
- Author(s)
  佐藤知雄、八木下尚子、新谷奈津美、井上永介、古田梨愛、渡邉俊樹、内丸薫、松岡雅雄、松本直樹、長谷川泰弘、山野嘉久.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 腎移植におけるHTLV-1感染症の危険性.2018
- Author(s)
  山内淳司、山野嘉久、佐藤知雄、八木下尚子、新谷奈津美、松岡雅雄、市丸直嗣、錦戸雅春、柴垣有吾、杉谷篤、中村信之、三重野牧子、湯沢賢治.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Current situation of patient centered medicines development in Japan.2018
- Author(s)
  Yamano Y.
- Organizer
  The 19th International Conference on Pharmaceutical Medicine (ICPM2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HTLV-1陽性臓器移植患者レジストリの構築.2018
- Author(s)
  山内淳司、山野嘉久、佐藤知雄、八木下尚子、新谷奈津美、松岡雅雄、市丸直嗣、錦戸雅春、柴垣有吾、杉谷篤、中村信之、三重野牧子、湯沢賢治.
- Organizer
  第54回日本移植学会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＴＬＶ-1母子感染の予防と対策.2018
- Author(s)
  山野嘉久.
- Organizer
  平成29年度不妊・不育・ＨＴＬＶ-1相談に関する研修.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＴＬＶ-1の基礎知識とキャリア妊産婦・患者への支援.2018
- Author(s)
  山野嘉久.
- Organizer
  平成29年度ＨＴＬＶ-1母子保健感染予防対策研修会.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 希少疾患HAMに対する患者レジストリの活用.2018
- Author(s)
  八木下尚子、山内淳司、佐藤知雄、山野嘉久.
- Organizer
  第30回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 希少難病HAMに対する新規治療薬の開発.2018
- Author(s)
  山野嘉久.
- Organizer
  第75回聖マリアンナ医科大学医学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 医師主導治験の実際～希少難病HAMを例に～2018
- Author(s)
  山野嘉久.
- Organizer
  日本線維筋痛症学会第10回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＡＭについて.2018
- Author(s)
  山野嘉久.
- Organizer
  第2回ＨＴＬＶ-1治療研究講演会.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Treatment of HAM/TSP.2018
- Author(s)
  Yamano Y.
- Organizer
  IRVA Tokyo Conference 2018 & International Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HTLV-1関連脊髄症に対する抗CCR4抗体製剤（モガムリズマブ）の医師主導治験.2018
- Author(s)
  佐藤知雄、八木下尚子、新谷奈津美、井上永介、古田梨愛、渡邉俊樹、内丸薫、松岡雅雄、松本直樹、長谷川泰弘、山野嘉久.
- Organizer
  第30回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ATL及びHAM発症に至る遺伝子発現異常の推移と運命制御メカニズム2018
- Author(s)
  山岸誠、新谷奈津美、石崎伊純、小林誠一郎、牧山純也、佐藤知雄、八木下尚子、宇都宮與、中村龍文、田中勇悦、渡邉俊樹、山野嘉久、内丸薫
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 腎移植後HTLV-1関連疾患の発症に関する全国調査.2018
- Author(s)
  山内淳司、山野嘉久、佐藤知雄、八木下尚子、新谷奈津美、松岡雅雄、市丸直嗣、錦戸雅春、柴垣有吾、杉谷篤、中村信之、三重野牧子、湯沢賢治.
- Organizer
  第30回日本神経免疫学会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Anti-C-C chemokine receptor 4 monoclonal antibody therapy in human T-lymphotropic virus type 1-associated myelopathy (HAM/TSP).2018
- Author(s)
  Yamano Y.
- Organizer
  11th Pan-Asian Committee on Treatment and Research in Multiple Sclerosis (PACTRIMS CONGRESS 2018)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 腎移植患者のHTLV-1関連疾患発症に関する全国調査.2018
- Author(s)
  山内淳司、山野嘉久、佐藤知雄、八木下尚子、新谷奈津美、松岡雅雄、市丸直嗣、錦戸雅春、柴垣有吾、杉谷篤、中村信之、三重野牧子、湯沢賢治.
- Organizer
  第23回日本神経感染症学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 患者レジストリが支えるHTLV-1関連脊髄症（HAM）研究の最近の進歩Recent Progress in the research for HTLV-1-associated Myelopathy (HAM) brought by patient registry.2018
- Author(s)
  山野嘉久.
- Organizer
  第59回日本神経学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAM患者レジストリ「HAMねっと」の運営.2018
- Author(s)
  八木下尚子、高橋克典、山内淳司、佐藤知雄、山野嘉久.
- Organizer
  第5回日本HTLV-1学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＡＴＬ患者の同種造血幹細胞移植後に慢性炎症性脱髄性多発ニューロパチーを発症した３症例の解析.2017
- Author(s)
  平野光人, 今井陽一, 神保光児, 小川弥穂, 越智清純, 川俣豊隆, 横山和明, 大野伸広, 山野嘉久, 福田隆浩, 内丸薫, 東條有伸.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 難病患者さんの笑顔を目指して　～臨床と基礎の研究成果を活かした医師主導治験の軌跡～.2017
- Author(s)
  山野嘉久.
- Organizer
  京都府立医科大学特別講義
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Progression Patterns of Osame’s Motor Disability Score for HAM/TSP Patients.2017
- Author(s)
  Inoue E, Coler-Reilly A, Araya N, Yagishita N, Sato T, Takata A, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMの患者レジストリによるリアルワールドデータを活用した治療薬開発の展望.2017
- Author(s)
  山野嘉久.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 希少難病HAMの患者レジストリを活用した治療薬開発への取り組みと展望.2017
- Author(s)
  山野嘉久.
- Organizer
  第17回CRCと臨床試験のあり方を考える会議2017
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Investigation of Human Leukocyte Antigen on Human T-Lymphotropic Virus Type-1 Associated Myelopathy (HAM) by the Rare Disease Bank.2017
- Author(s)
  Tada M, Yamano Y, Sato T, Sasaki M, Sakate R, Hinomura A, Hirata M, Tanaka H, Kojima H, Kohara A, Matsuyama A.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] IL-10-mediated Signals as a Switch to Proliferation in HTLV-1-infected T Cells.2017
- Author(s)
  Sawada L, Nagano Y, Hasegawa A, Ito S, Sato T, Yamano Y, Tanaka Y, Masuda T, Kannagi M.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Daily Prednisolone Slows the Progression of HAM/TSP.2017
- Author(s)
  Coler-Reilly A, Sato T, MatsuzakiT, Nakagawa M, Niino M, Nagai M, Nakamura T, Takenouchi N, Araya N, Yagishita N, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] The New Phase of HAM/TSP Research.2017
- Author(s)
  Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Patient Satisfaction Survey for HAM-net Registrants.2017
- Author(s)
  Suzuki H, Sato K, Kikuchi T, Kimura M, Arifuku H, Komita M, Shimada K, Seki K, Tachibana M, Yagishita N, Coler-Reilly A, Sato T, Araya N, Ishikawa M, Koike M, Saito Y, Takata A, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＴＬＶ－１関連脊髄症（ＨＡＭ）の新たな運動障害重症度評価指標の提案.2017
- Author(s)
  八木下尚子, 佐藤知雄, 長谷川大輔, 新谷奈津美, 井上永介, 高田礼子, 山野嘉久.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Development of a New Assay for Quantification of HTLV-1 Proviral DNA.2017
- Author(s)
  Higashikuse Y, Nagai G, Araya N, Yagishita N, Sato T, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Effect of Biologic Agents on HAM/TSP with Rheumatoid Arthritis.2017
- Author(s)
  Matsuzaki T, Saito M, Yamano Y, Nagai M, Takashima H, Izumihara T, Yoshitama T, Kubota R.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] A New Index Describing Urinary Dysfunction in Patients with Human T-lymphotropic Virus Type 1-associated Myelopathy.2017
- Author(s)
  Yamakawa N, Amano S, Kawakami H, Yamashita H, Yagishita N, Araya N, Sato T, Takata A, Matsuo T, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 医師主導治験の計画と実施～希少難病ＨＡＭを例として～.2017
- Author(s)
  山野嘉久.
- Organizer
  愛媛大学医学部附属病院第32回創薬育薬セミナー.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Effectiveness of Low-Dose Oral Prednisolone to Treat and Slow Progression of HAM/TSP: A Nationwide Prospective Cohort Study.2017
- Author(s)
  Sato T, Inoue E, Yagishita N, Araya N, Takata A, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＡＭ患者レジストリを活用した低用量経口プレドニゾロン維持療法の有効性と安全性に関する検討.2017
- Author(s)
  佐藤知雄, 井上永介, 八木下尚子, 新谷奈津美, 長谷川大輔, 高田礼子, 山野嘉久.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] The Development of Human T-cell Leukemia Virus Type 1 (HTLV-1)-Associated Myelopathy (HAM)-Mimicking Myelitis Following Allogeneic Hematopoietic Stem Cell Transplantation for Acute Type Adult T-cell Leukemia-lymphoma (ATL).2017
- Author(s)
  Kawano N, Yamano Y, Kawano S, Kawamata T, Yoshida S, Kuriyama T, Uchimaru K, Marutsuka K, Minato S, Yamashita K, Ochiai H, Shimoda K, Ishikawa F, Kikuchi I.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Phase 1/2a study of Mogamulizumab, an anti-CCR4 monoclonal antibody, in patients with HTLV-1-associated myelopathy (HAM/TSP).2017
- Author(s)
  Yamano Y, Sato T, A. Coler-Reilly, Yanagisawa N, Araya N, Inoue E, Furuta R, Watanabe T, Uchimaru K, Matsuoka M, Matsumoto N, Hasegawa Y.
- Organizer
  XXIII World Congress of Neurology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＡＭの患者レジストリによるリアルワールドデータを活用した治療薬開発の展望.2017
- Author(s)
  山野嘉久.
- Organizer
  第35回日本神経治療学会総会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Prevalence, Incidence, and Evidence of High ATL Risk among HAM/TSP Patients.2017
- Author(s)
  Araya N, Sato T, Yagishita N, Coler-Reilly A, Uchimaru K, Yamano Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Potential contribution of IL-10-mediated STAT3 signals to push HTLV-1-infected cells towards proliferation by enhancing survivin and IRF4 expression.2017
- Author(s)
  Sawada L, Nagano Y, Hasegawa A, Ito S, Sato T, Yamano Y, Tanaka Y, Masuda T, Kannagi M.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Comparative Transcriptome Analysis of HTLV-1-infected Cells and ATL Cells.2017
- Author(s)
  Yamagishi M, Nakano K, Fujikawa D, Kobayashi S, Araya N, Sato T, Yagishita N, Iwanaga M, Utsunomiya A, Tanaka Y, Yamano Y, Watanabe T, Uchimaru K.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMに対する新規治療薬の開発.2017
- Author(s)
  山野嘉久.
- Organizer
  第22回日本神経感染症学会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] ＨＴＬＶ－１　プロウイルスＤＮＡ検出キットの臨床的有用性の検討.2017
- Author(s)
  宮地恵子, 東久世裕太, 小野達也, 永井豪, 篠田達也, 関野久邦, 井上恵, 三浦清徳, 小林誠一郎, 内丸薫, 山野嘉久.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] High Risk with Human T-cell Leukemia Virus Type 1 for HTLV-1 Associated Myelopathy after Living Kidney Transplantation in Japan.2017
- Author(s)
  Yuzawa K, Matsuoka M, Yamano Y, Ichimaru N, Nishikido M, Shibagaki Y, Sugitani A, Nakamura N, Mieno M, Yamauchi J.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 臨床経過とバイオマーカーに基づくＨＡＭの疾患活動性分類基準の提案.2017
- Author(s)
  長谷川大輔, 八木下尚子, 井上永介, 新谷奈津美, 髙田　礼子, 長谷川泰弘, 佐藤知雄, 山野嘉久.
- Organizer
  第４回日本ＨＴＬＶ－１学会学術集会
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 患者レジストリを活用した難病医療の充実と新薬開発の促進.2017
- Author(s)
  山野嘉久.
- Organizer
  医療ビッグデータコンソーシアム　第1回ライフサイエンス部会.
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Biomarkers for Predicting Treatment Response in Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).2017
- Author(s)
  Tamaki K, Sato T, Coler-Reilly A, Inoue E, Tsugawa J, Yamano Y, Tsuboi Y.
- Organizer
  18th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  〔Grand Arc Hanzomon〕東京都千代田区
- Year and Date
  2017-03-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 患者レジストリがもたらす難病医療の充実と新薬開発について.2017
- Author(s)
  山野嘉久.
- Organizer
  中枢性尿崩症(CDI)の会総会・勉強会　難病医療の充実とネットワーク
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMの分子病態解明による治療薬開発の新展開2016
- Author(s)
  山野嘉久.
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県（鹿児島市）〔鹿児島県市町村自治会館〕
- Year and Date
  2016-08-26
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMのCCR4モノクローナル抗体療法2016
- Author(s)
  山野嘉久
- Organizer
  第34回日本神経治療学会総会
- Place of Presentation
  鳥取（米子市）〔米子市文化ホール〕
- Year and Date
  2016-11-03
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HTLV-1関連脊髄症（HAM）におけるHAS-Flow法を用いたATL発症高危険度患者の予測2016
- Author(s)
  新谷奈津美、佐藤知雄、八木下尚子、高橋克典、内丸薫、山野嘉久.
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県（鹿児島市）〔鹿児島県市町村自治会館〕
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 生体腎移植におけるHTLV-1感染リスクについて2016
- Author(s)
  山野嘉久
- Organizer
  第53回大阪腎移植病理組織研究会
- Place of Presentation
  大阪（大阪市北区）〔ホテルグランヴィア大阪〕
- Year and Date
  2016-11-11
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Viruses in neuroimmunological disorders.2016
- Author(s)
  Yamano Y.
- Organizer
  13th International Congress of Neuroimmunology(ISNI 2016)
- Place of Presentation
  Jerusalem, Israel
- Year and Date
  2016-09-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAMの病態機序に基づいた疾患修飾薬の開発.2016
- Author(s)
  山野嘉久.
- Organizer
  日沼賴夫先生メモリアルシンポジウムHTLV-1 研究の現況と展望
- Place of Presentation
  京都府京都市（京都大学芝蘭会館山内ホール）
- Year and Date
  2016-03-16
- Invited
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] IL-10はsurvivinとIRF4の誘導を介してHTLV-1感染細胞の増殖を促進する2016
- Author(s)
  Sawada L, 永野佳子, 長谷川温彦, 金井光, 佐藤知雄, 山野嘉久, 田中勇悦, 神奈木真理.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  神奈川（横浜市西区）〔パシフィコ横浜〕
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAM患者における治療効果を予測するバイオマーカーの検討2016
- Author(s)
  玉木慶子、佐藤知雄、津川潤、山野嘉久、坪井義夫.
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県（鹿児島市）〔鹿児島県市町村自治会館〕
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAM発症から診断までの期間における納の運動障害重症度の経時推移の解析2016
- Author(s)
  井上永介、Ariella Coler-Reilly、新谷奈津美、八木下尚子、佐藤知雄、高田礼子、山野嘉久.
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県（鹿児島市）〔鹿児島県市町村自治会館〕
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] 希少難病HAMの分子病態解明による治療薬開発の新展開2016
- Author(s)
  山野嘉久
- Organizer
  第1回日本臨床薬理学会関東・甲信越地方会
- Place of Presentation
  神奈川県（横浜市）〔横浜市社会福祉センター〕
- Year and Date
  2016-09-03
- Invited
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] HAM患者に対する経口ステロイド維持療法の長期的効果2016
- Author(s)
  佐藤知雄、Ariella Coler-Reilly、新谷奈津美、八木下尚子、中村龍文、永井将弘、新野正明、竹ノ内徳博、中川正法、松崎敏男、山野嘉久.
- Organizer
  第3回日本HTLV-1学会学術集会
- Place of Presentation
  鹿児島県（鹿児島市）〔鹿児島県市町村自治会館〕
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16H05323
[Presentation] Humanized anti-CCR4 antibody KW0761 targets HTLV-1-infected CD4+CCR4+ and CD8+CCR4+ T-cells to treat HAM/TSP.2015
- Author(s)
  Yamano Y, Yamauchi J, Coler-Reilly A, Sato T, Araya N, Yagishita N, Kunitomo Y, Takahashi K, Tanaka Y, Akiyama H, Hasegawa Y, Utsunomiya A.
- Organizer
  17th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Martinique, Frenchi West Indies
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1 induces a Th1-like state in CD4+CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP.2015
- Author(s)
  Yamano Y.
- Organizer
  40Years of Neuroimmunology
- Place of Presentation
  Bethesda, Maryland, USA.
- Year and Date
  2015-04-19
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1 Tax induces Th1 master regulator T-bet and thus IFN-γ in CD4+CCR4+ T-cells of virus-associated myelopathy patients.2015
- Author(s)
  Araya N, Sato T, Tomaru U, Coler-Reilly A, Yagishita N, Yamauchi J, Hasegawa A, Kannagi M, Akiyama H,Hasegawa Y, Takahashi K, Kunitomo Y, Tanaka Y, Utsunomiya A, Jacobson S, Yamano Y.
- Organizer
  17th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Martinique, Frenchi West Indies
- Year and Date
  2015-06-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] How does HTLV-1 cause CNS disease? - The importance of cross-talk between infected T-cells and astrocytes.2015
- Author(s)
  Yamano Y.
- Organizer
  The Inaugural Asia-Pacific School of Neuroimmunology Meeting
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2015-08-30
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1関連脊髄症(HAM)における髄液細胞のケモカイン受容体解析.2015
- Author(s)
  佐藤知雄, 安藤仁, 高橋克典, 國友康夫, Ariella Coler-Reilly, 新谷奈津美, 八木下尚子, 山野嘉久.
- Organizer
  第2回日本HTLV-1学会学術集会
- Place of Presentation
  東京都港区（東京大学医科学研究所）
- Year and Date
  2015-08-22
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HAMの治療展望.2015
- Author(s)
  山野嘉久.
- Organizer
  第27回日本神経免疫学会学術集会
- Place of Presentation
  岐阜県岐阜市（長良川国際会議場）
- Year and Date
  2015-09-15
- Invited
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 希少な神経難病：HTLV-1関連脊髄症（HAM）の新薬開発への挑戦2014
- Author(s)
  山野嘉久.
- Organizer
  第35回日本臨床薬理学会学術総会　シンポジウム24
- Place of Presentation
  愛媛県（松山市）〔ひめぎんホール〕
- Year and Date
  2014-12-04
- Invited
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 慢性C型肝炎に対するインターフェロン療法後に、抗アクアポリン4抗体及び抗HTLV-1抗体陽性の脊髄長大病変を呈した49歳女性例.2014
- Author(s)
  余郷麻希子，大本周作，向井泰司，安部宏，相澤良夫，高橋利幸，山野嘉久，鈴木正彦.
- Organizer
  第210回日本神経学会関東・甲信越地方会
- Place of Presentation
  東京都（千代田区）〔砂防会館〕
- Year and Date
  2014-09-06
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] CXCL10 and Neopterin in cerebrospinal fluid are Candidate Prognostic Biomarkers for HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis.2013
- Author(s)
  Yamano Y., Sato T., Ando H., Araya N., Yagishita N., Yamauchi J., Coler-Reilly A., Utsunomiya A., Jacobson S., Izumo S.
- Organizer
  The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Virus-induced CXCL10-CXCR3 positive feedback loop via astrocytes is critical for maintaining chronic inflammatory lesions in HAM/TSP.2013
- Author(s)
  Sato T., Ando H., Tomaru U., Yoshida M., Utsunomiya A., Yamauchi J., Araya N., Yagishita N., Coler-Reilly A., Jacobson S., Yamano Y.
- Organizer
  The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Search for a model of drug efficacy for a rare chronic progressive neurological disease HAM/TSP2013
- Author(s)
  Yamano Y.
- Organizer
  The 3rd International Symposium of Early Stage Clinical Trial
- Place of Presentation
  Yokohama
- Year and Date
  2013-02-02
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] CXCL10, CXCL9 and Neopterin in cerebrospinal fluid as Candidate Prognostic Biomarkers for HAM/TSP.2013
- Author(s)
  Yamano Y., Sato T., Coler-Reilly A., Ando H., Araya N., Yagishita N., Yamauchi J., Utsunomiya A., Jacobson S., Izumo S.
- Organizer
  The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 成人T細胞白血病ウイルス関連疾患における新規治療標的同定を目的とした定量膜プロテオームプロファイリング.2013
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、宇都宮與、中川英刀、山野嘉久、植田幸嗣.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県（横浜市）〔パシフィコ横浜〕
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Development of novel molecular targeted therapies for HAM/TSP.2013
- Author(s)
  Yamano Y.
- Organizer
  第6回HTLV-1研究会・シンポジウム／第3回HTLV-1国際シンポジウム
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所講堂〕
- Invited
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1関連脊髄症（HAM）の治療標的としてのCCR4+CD4+T細胞2013
- Author(s)
  佐藤知雄、新谷奈津美、安藤仁、Ariella Coler-Reilly、山内淳司、八木下尚子、山野嘉久.
- Organizer
  第6回HTLV-1研究会・シンポジウム
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所講堂〕
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HAMにおける抗CCR4抗体製剤の有用性に関する検討2013
- Author(s)
  山野嘉久, 山内淳司, 新谷奈津美, 安藤仁, Ariella Color-Reilly, 八木下尚子, 宇都宮與, 佐藤知雄.
- Organizer
  第25回日本神経免疫学会学術集会
- Place of Presentation
  山口県（下関市）〔海峡メッセ下関〕
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Nation-wide epidemiological study in Japan on HTLV-1 associated myelopathy/tropical spastic paraparesis using HAM-net, a novel patient registration system.2013
- Author(s)
  Coler-Reilly A., Hashimoto M., Yagishita N., Sato T., Ando H., Yamauchi J., Araya N., Kimura M., Yamano Y., Takata A.
- Organizer
  The 16th International Conference on Human Retrovirology: HTLV and Related Viruses
- Place of Presentation
  Montreal, Canada
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 同種造血幹細胞移植後ATL患者からの新規HTLV-1特異的CD4エピトープの同定（Identification of novel HTLV-1-specific CD4 epitopes in ATL patients after hematopoietic stem cell transplantation.）2013
- Author(s)
  Hasegawa　A., Tamai Y., Takamori A., Sasada A., Tanosaki R., Choi I., Utsunomiya A., Suehiro Y., Maeda Y., Yamano Y., Uike N., Kannagi M.
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  神奈川県（横浜市）〔パシフィコ横浜〕
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 脳脊髄液プロテオーム解析によるヒトTリンパ好性ウイルス関連脊髄症(HAM/TSP)に対する重症度診断アルゴリズムの構築.2013
- Author(s)
  石原誠人、新谷奈津美、佐藤知雄、山野嘉久、中川英刀、植田幸嗣.
- Organizer
  第6回HTLV-1研究会・シンポジウム
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所講堂〕
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Label free quantitative proteome analysis on cerebrospinal fluid to discover severity grade markers for Human T-cell leukemia virus type 1 associated myelopathy/tropic spastic paraparesis (HAM/TSP).2013
- Author(s)
  Ishihara M, Araya N, Sato T, Fujii R, Tatsuguchi A, Saichi N, Nakagawa H, Yamano Y, Ueda K.
- Organizer
  HUPO 2013 12th Annual World Congress
- Place of Presentation
  Kanagawa, Japan
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 脳脊髄液プロテオームプロファイリングによる HAM/TSP重症度指針マーカーの同定. 第5 回 HTLV-1 研究会2012
- Author(s)
  石原誠人, 新谷奈津美, 佐藤知雄, 山野嘉久, 中村祐輔, 中川英刀, 植田幸嗣
- Organizer
  第1回 ATL シンポジウム・HTLV-1 国際シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1関連脊髄症（HAM）の臨床経過と関連する疾患活動性マーカーの同定2012
- Author(s)
  山野嘉久
- Organizer
  第53回日本神経学会学術大会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMにおけるHTLV-1感染T細胞の異常2012
- Author(s)
  山野嘉久
- Organizer
  第5回HTLV-1研究会・第1回ATLシンポジウム・HTLV-1国際シンポジウム
- Place of Presentation
  東京大学医科学研究所（東京都港区）
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 関連脊髄症(HAM)の進行度に関連するバイオマーカーの同定.2012
- Author(s)
  佐藤知雄, 安藤仁, 新谷奈津美, 山内淳司, 八木下尚子, 出雲周二, 山野嘉久 .
- Organizer
  第17回日本神経感染症学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAM 病態研究の進歩に基づく新規治療薬の可能性2012
- Author(s)
  山野嘉久
- Organizer
  第10回HAM治療研究会
- Place of Presentation
  大阪
- Year and Date
  2012-07-27
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] ステロイドのHAM 患者血中 HTLV-1 プロウイルス量に対する影響と免疫抑制によるHTLV-1 関連疾患発症リスクに関する検討.2012
- Author(s)
  山内淳司, 安藤仁, 新谷奈津美, 佐藤知雄, 八木下尚子, 山野嘉久
- Organizer
  第17回日本神経感染症学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 関連脊髄症(HAM)の炎症慢性化に果たす CXCL10 の役割と治療応用への解析2012
- Author(s)
  安藤仁, 佐藤知雄, 新谷奈津美, 八木下尚子, 山内淳司アリエラ・コラーライリー, 山野嘉久 .
- Organizer
  第17回日本神経感染症学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 関連脊髄症(HAM)の進行度に関連する新規バイオマーカーとしての髄液 CXCL10 の重要性.2012
- Author(s)
  佐藤知雄, 安藤仁, 新谷奈津美, 山内淳司, 八木下尚子, 出雲周二, 山野嘉久
- Organizer
  第5回 HTLV-1 研究会・第1 回 ATL シンポジウム・HTLV-1 国際シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] ステロイドの血中 HTLV-1 プロウイルス量に対する影響と免疫抑制による HTLV-1 関連疾患発症リスクに関する検討.2012
- Author(s)
  山内淳司, 安藤仁, 新谷奈津美, 佐藤知雄, 八木下尚子, 山野嘉久 .
- Organizer
  第5回 HTLV-1 研究会・第1 回 ATL シンポジウム・HTLV-1 国際シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] ヒトT細胞白血病ウイルス(HTLV-1)の基礎知識とキャリアの相談について2012
- Author(s)
  山野嘉久
- Organizer
  山梨県福祉保健部主催HTLV-1感染症に関する相談検査講習会
- Place of Presentation
  山梨県国際交流センター(山梨県甲府市)(招待講演)
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMにおけるCXCL10の炎症慢性化機構における重要性と治療標的としての可能性2012
- Author(s)
  山野嘉久、他
- Organizer
  第24回日本神経免疫学会学術集会
- Place of Presentation
  軽井沢プリンスホテルウエスト（長野県北佐久郡）
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1関連脊髄症(HAM)の臨床病型:臨床経過と検査所見に基づいた分類2011
- Author(s)
  山野嘉久, 他
- Organizer
  第4回HTLV-1研究会
- Place of Presentation
  東京大学弥生講堂(東京都)
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMの免疫病態2011
- Author(s)
  山野嘉久
- Organizer
  東京大学医科学研究所GCOE「疾患医科学ミニシンポジウムシリーズ」第3回『HTLV-1と疾患～成人T細胞白血病(ATL)とHTLV-1関連脊髄症(HAM)の病態解明の進歩と治療の現状～』
- Place of Presentation
  東京大学医科学研究所(東京都)(招待講演)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1感染細胞を標的とした治療法の開発2011
- Author(s)
  山野嘉久, 他
- Organizer
  厚生労働省科学研究費補助金研究事業 2010年度HTLV-1関連合同班会議
- Place of Presentation
  東京(国立感染研究所)
- Year and Date
  2011-02-19
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] ヒトT細胞白血病ウイルス(HTLV-1)の現状について2011
- Author(s)
  山野嘉久
- Organizer
  神奈川難病相談・支援センター主催医療講演会・相談会
- Place of Presentation
  かながわ県民センター(神奈川県横浜市)(招待講演)
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1をHAMについてもっと知りましょう2011
- Author(s)
  山野嘉久
- Organizer
  第1回HTLV-1医療講演会・交流会
- Place of Presentation
  フォンタナの丘かもう(鹿児島県姶良市)(招待講演)
- Year and Date
  2011-12-11
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1総合対策を踏まえた診療体制の整備とHAMの研究について2011
- Author(s)
  山野嘉久
- Organizer
  聖マリアンナ医科大学第14回Marianna Research Council
- Place of Presentation
  聖マリアンナ医科大学(神奈川県川崎市)(招待講演)
- Year and Date
  2011-12-22
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 関連脊髄症(HAM)患者でのフコイダン療法によるウイルス量の減少2011
- Author(s)
  山野嘉久, 新谷奈津美, 佐藤知雄, 中村龍文, 森直樹, 鈴木登
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Clinical subtype of HAM/TSP based on clinical course and laboratory findings2011
- Author(s)
  Yamano Y., et al
- Organizer
  15th International Conference on Human Retrovirology : HTLV and Related Viruses
- Place of Presentation
  Aula Pieter De Somer (Leuven, Belgium)
- Year and Date
  2011-06-05
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMの重症度別治療指針に資する疾患活動性バイオマーカーの有用性とステロイド治療による反応性2011
- Author(s)
  山野嘉久
- Organizer
  平成22年度厚生労働省科学研究費補助金難知性疾患克服研究事業「HAMの新規バイオマーカー同定による重症度別治療指針の作成と病因細胞標的治療法の開発」平成22年度第2回合同班会議
- Place of Presentation
  鹿児島(鶴陵会館)
- Year and Date
  2011-01-08
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1の母子感染予防対策について2011
- Author(s)
  山野嘉久
- Organizer
  横須賀市主催母子学術研修会
- Place of Presentation
  横須賀市役所(神奈川県横須賀市)(招待講演)
- Year and Date
  2011-10-25
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Clinical subtype of HAM/TSP based on clinical course and laboratory findings.2011
- Author(s)
  Yamano Y., Sato T., Araya N., et al.
- Organizer
  15th International Conference on Human Retrovirology: HTLV and Related Viruses.
- Place of Presentation
  Leuven, Belgium.
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1関連脊髄症(HAM)における免疫異常2011
- Author(s)
  山野嘉久
- Organizer
  第1103回京都大学ウイルス研究所セミナー
- Place of Presentation
  京都大学ウイルス研究所(京都府京都市)(招待講演)
- Year and Date
  2011-04-04
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1ウィルスと母子感染2011
- Author(s)
  山野嘉久
- Organizer
  世田谷区産婦人科医会主催学術講演会
- Place of Presentation
  世田谷区医師会会館保健センター(東京都)(招待講演)
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 関連脊髄症(HAM)における免疫異常2011
- Author(s)
  山野嘉久
- Organizer
  第1103回京都大学ウイルス研究所セミナー
- Place of Presentation
  京都
- Year and Date
  2011-04-04
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] ヒトT細胞白血病ウイルス(HTLV-1)とHTLV-1関連脊髄症(HAM)について-国の総合対策の内容、および臨床や研究の取り組み-2011
- Author(s)
  山野嘉久
- Organizer
  聖マリアンナ医科大学病院メディカルサポートセンター主催医療従事者対象第75回難病研修会
- Place of Presentation
  聖マリアンナ医科大学(神奈川県川崎市)(招待講演)
- Year and Date
  2011-06-28
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] ER stress signaling as a chronicity of imflammation2011
- Author(s)
  Yagishita N, Aratani S, Yamano Y, Nishioka K, Nakajima T
- Organizer
  2nd Tokyo-Shanghai Rheumatology Workshop
- Place of Presentation
  Tokyo, Japan(Hilton Tokyo Bay Hotel)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-20249052
[Presentation] 難病対策に関連する制度HTLV-1対策について2011
- Author(s)
  山野嘉久
- Organizer
  国立保健医療科学院主催平成23年度特定疾患医療従事者研修
- Place of Presentation
  国立保健医療科学院(埼玉県和光市)(招待講演)
- Year and Date
  2011-10-24
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1関連脊髄症(HAM)患者でのフコイダン療法によるウイルス量の減少2011
- Author(s)
  山野嘉久, 他
- Organizer
  第52回日本神経学会学術大会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMにおけるHTLV-1 TaxによるヘルパーCD4+ T細胞の可塑的変化とその慢性炎症病変形成への関与2011
- Author(s)
  山野嘉久, 他
- Organizer
  平成22年度免疫性神経疾患に関する調査研究班班会議
- Place of Presentation
  東京(都市センターホテル)
- Year and Date
  2011-01-27
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1の母子感染予防対策について2011
- Author(s)
  山野嘉久
- Organizer
  平成23年度神奈川県母子保健対策検討委員会
- Place of Presentation
  かながわ県民センター(神奈川県横浜市)(招待講演)
- Year and Date
  2011-09-06
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Importance of E3 ubiquitin ligase Synoviolin in fibrogenesis2011
- Author(s)
  Yagishita N, Hasegawa D, Aratani S, Yamano Y, Nakajima T
- Organizer
  The 2011 ACR/ARHP Annual Scientific Meeting
- Place of Presentation
  Chicago, U. S. A
- Year and Date
  2011-11-08
- Data Source
  KAKENHI-PROJECT-20249052
[Presentation] HAMの重症度別治療指針に資する疾患活動性バイオマーカーの有用性とステロイド治療による反応性2011
- Author(s)
  山野嘉久, 他
- Organizer
  平成22年度免疫性神経疾患に関する調査研究班班会議
- Place of Presentation
  東京(都市センターホテル)
- Year and Date
  2011-01-27
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMにおけるIFN-γ+CD4+CD25+CCR4+病原性T細胞の発生機構とその脊髄炎症病巣へのリクルート機構に関する解析2010
- Author(s)
  山野嘉久, 他
- Organizer
  第3回HTLV-1研究会
- Place of Presentation
  東京(東京大学医科学研究所)
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMにおける血中sIL-2RとIP-10のバイオマーカーとしての有用性2010
- Author(s)
  山野嘉久, 他
- Organizer
  第51回日本神経学会
- Place of Presentation
  東京(東京国際フォーラム)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] 肝線維化における E3 ユビキチリンリガーゼシノビオリンの関与国際科学振興財団フォーラム分子消化器病学研究会2010
- Author(s)
  長谷川大輔、松本伸行、八木下尚子、荒谷聡子、山野嘉久、西岡久寿樹、中島利博、伊東文生
- Organizer
  第18回浜名湖シンポジウム
- Place of Presentation
  浜名湖
- Data Source
  KAKENHI-PROJECT-20249052
[Presentation] HTLV-1 infected CD4+CD25+CCR4+ T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease.2010
- Author(s)
  Yamano Y.
- Organizer
  Viruses, Genes and Cancer 2010
- Place of Presentation
  Venezia, Italy (Palazzo Cavalli Franchetti)
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Noble advance in rheumatology by Asian rheumatologist-Current novel achievement in rheumatology.2010
- Author(s)
  Yamano Y.
- Organizer
  14th Congress of Asia Pacific League of Associations for Rheumatology
- Place of Presentation
  Hong Kong, China (Hong Kong Convention and Exhibition Centre)
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] The plasma levels of soluble IL-2 receptor and CXCL10 are usefulindicators for disease activity in patients with HAM/TSP.2010
- Author(s)
  Sato T., Araya N., Suzuki N., Yamano Y.
- Organizer
  Viruses, Genes and Cancer 2010
- Place of Presentation
  Venezia, Italy.
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 infected CD4+CD25+CCR4+ T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease. Viruses2010
- Author(s)
  Yamano Y.
- Organizer
  Genes and Cancer 2010
- Place of Presentation
  Venezia Italy
- Year and Date
  2010-10-01
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-関連脊髄症(HAM)における IFN-γ+ CD4+CD25+CCR4+病原性 T細胞発生の分子機構解析.2010
- Author(s)
  新谷奈津美, 佐藤知雄, 安藤仁, 宇都宮與, 山野嘉久.
- Organizer
  第33回日本分子生物学会年会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Both qualitative increase of TCR-binding capacity and quantitative increase of the TCRs on the cell surface define the higher avidity of Tax-specific CTL in HLA-A2 transgenic mice.2010
- Author(s)
  Kitazono T., Okazaki T., Yamano Y., etal.
- Organizer
  14th International Congress of Immunology
- Place of Presentation
  Kobe, Japan.
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HLA-A2 トランスジェニックマウスをもちいたTax特異的細胞障害性 T 細胞の解析2010
- Author(s)
  北薗貴子, 岡崎貴裕, 新谷奈津美, 山野嘉久, et al
- Organizer
  第3回HTLV-1 研究会・合同班会議
- Place of Presentation
  東京
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAM の疾患活動性血中バイオマーカーの同定およびステロイドの長期予後改善効果に関する検討.2010
- Author(s)
  佐藤知雄, 新谷奈津美, 安藤仁, 山野嘉久.
- Organizer
  第3回 HTLV-1 研究会・合同班会議
- Place of Presentation
  東京
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HTLV-1 promotes the plasticity of HTLV-1 infected T-cells through the regulation of T-bet transcriptional activation in HAM/TSP. Viruses2010
- Author(s)
  Araya N., Sato T., Utsunomiya A., Jacobson S. Yamano Y.
- Organizer
  Genes and Cancer 2010
- Place of Presentation
  Venezia, Italy.
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAM における IFN-γ+ CD4+CD25+CCR4+病原性T細胞の発生機構とその脊髄炎症病巣へのリクルート機構に関する解析2010
- Author(s)
  山野嘉久, 佐藤知雄, 新谷奈津美, 安藤仁, 神奈木真理, 田中勇悦, 宇都宮與
- Organizer
  第3回 HTLV-1 研究会・合同班会議
- Place of Presentation
  東京
- Year and Date
  2010-08-29
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Noble advance in rheumatology by Asian rheumatologist-Current novel achievement in rheumatology.2010
- Author(s)
  Yamano Y.
- Organizer
  14th Congress of Asia Pacific League of Associations for Rheumatology
- Place of Presentation
  Hong Kong
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAM における血中 sIL-2R と IP-10 のバイオマーカーとしての有用性2010
- Author(s)
  山野嘉久, 佐藤知雄, 新谷奈津美, 鈴木登.
- Organizer
  第5回日本神経学会
- Place of Presentation
  東京
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMにおけるウイルス感染CD4+CD25+CCR4+FoxP3^<low>T細胞の増加と機能異常2009
- Author(s)
  山野嘉久、他
- Organizer
  第21回日本神経免疫学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HAMにおけるウイルス感染CD4+CD25+CCR4+FoxP3^<low> T細胞の増加と機能異常2009
- Author(s)
  山野嘉久, 他
- Organizer
  第21回日本神経免疫学会学術集会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Deficiency of innate immunity in HTLV-1 associated neuroimmunological disorder2008
- Author(s)
  阿座上和子、山野嘉久他
- Organizer
  第38回日本免疫学会総会・学術大会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Systemic Myotonic Pain Syndrome : A New Clinical Entity Found From Fibromyalgia.2008
- Author(s)
  Yamano Y., et al
- Organizer
  13th Congress of the Asia Pacific League of association for Rheumatology.
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Detection of Immuno-Pathogenic T cells In HTLV-I Associated Neuroimunological Disease : Discovery of A New T Cell Population.2008
- Author(s)
  Yamano Y., et al
- Organizer
  13th Congress of the Asia Pacific League of association for Rheumatology.
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HTLV-I関連脊髄症(HAM)患者におけるCD4+CD25+FoxP3^<low>異常T細胞の増加2008
- Author(s)
  山野嘉久、他
- Organizer
  第49回日本神経学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] IFN-γ producing CD4+CD25+CCR4+FoxP3^<low> T cells are increased and correlated with disease severity in HTLV-I associated neuroimunological disease2008
- Author(s)
  山野嘉久, 他
- Organizer
  第38回日本免疫学会総会・学術大会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] 全身性筋緊張性疼痛症候群 : 線維筋痛症から見出された新しい疾患概念2008
- Author(s)
  山野嘉久、他
- Organizer
  第29回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Increased Prevalence Of Group A b-hemolytic Streptococcus Among Ethnic Population In Kyrgyzstan Defined By Rapid Antigen Detection Test2008
- Author(s)
  Omurzakova N.A., Yamano Y. et.al.
- Organizer
  13th Congress of the Asia Pacific League of association for Rheumatolog
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Systemic Myotonic Pain Syndrome : A New Clinical Entity Found From Fibromyalgia2008
- Author(s)
  Yamano Y., et.al
- Organizer
  13th Congress of the Asia Pacific League of association for Rheumatolog
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Detection of Immuno-Pathogenic T cells In HTLV-I Associated Neuroimunological Disease : Discovery of A New T Cell Population2008
- Author(s)
  Yamano Y., et.al.
- Organizer
  13th Congress of the Asia Pacific League of association for Rheumatolog
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HTLV-I関連脊髄症(HAM)患者におけるIFN-γ産生CD4+CD25+CCR4+FoxP3^<low>異常T細胞の増加2008
- Author(s)
  山野嘉久, 他
- Organizer
  第1回HTLV研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] ATLおよびその前段階におけるTax特異的T細胞の低応答性 : 免疫学的ATL危険因子とその回避2008
- Author(s)
  神奈木真理、山野嘉久、他
- Organizer
  第1回HTLV-I研究会
- Place of Presentation
  東京
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HTLV-1 taxによるRhoGTPaseを介した細胞運動機能への作用2008
- Author(s)
  新谷奈津美、山野嘉久、他
- Organizer
  第12回日本神経ウイルス研究会学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HTLV-I関連脊髄症(HAM)における自然免疫系の異常2008
- Author(s)
  佐藤知雄、山野嘉久、他
- Organizer
  第12回日本神経ウイルス研究会学術集会
- Place of Presentation
  鹿児島
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HTLV-I関連脊髄症(HAM)におけるNatural killer T(NKT)細胞および樹状細胞の異常2008
- Author(s)
  佐藤知雄、山野嘉久、他
- Organizer
  第1回HTLV-I研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] Deficiency of innate immunity in HTLV-1 associated neuroimmunological disease2008
- Author(s)
  Azakami K., Yamano Y. et.al.
- Organizer
  13th Congress of the Asia Pacific League of association for Rheumatology
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HTLV-I関連脊髄症(HAM)患者におけるIFN-γ産生CD4+CD25+CCR4+FoxP3^<low>異常T細胞の増加2008
- Author(s)
  山野嘉久、他
- Organizer
  第1回HTLV-I研究会
- Place of Presentation
  東京
- Year and Date
  2008-08-24
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HAM(HTLV-I関連脊髄症)におけるNKT細胞2008
- Author(s)
  阿座上和子、山野嘉久、他
- Organizer
  第29回日本炎症・再生医学会
- Place of Presentation
  東京
- Year and Date
  2008-07-09
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] IFN-γproducing CD4+CD25+CCR4+FoxP3^<low> T cells are increased and correlated with disease severity in HTLV-I associated neuroimunological disease2008
- Author(s)
  山野嘉久、他
- Organizer
  第38回日本免疫学会総会・学術大会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] 線維筋痛症における筋不随意運動2007
- Author(s)
  山野嘉久、他
- Organizer
  第1回線維筋痛症研究会
- Place of Presentation
  東京
- Year and Date
  2007-09-24
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] High expression of CD28 co-stimulatory molecules and low expression of CTLA-4 inhibitory molecule on CD4+CD25+ T cells in HTLV-I associated myelopathy(HAM/TSP)2007
- Author(s)
  Yamano Y., et. al.
- Organizer
  International conference on Human Retrovirology: HTLV-I and Related Viruses.
- Place of Presentation
  Hakone, Japan
- Year and Date
  2007-05-24
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] 無症候性キャリアーにおけるT細胞の低応答性2007
- Author(s)
  清水由紀子、山野嘉久、他
- Organizer
  第55回日本ウイルス学術集会
- Place of Presentation
  札幌
- Year and Date
  2007-10-21
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] High expression of CD28 co-stimulatory molecules and low expression of CTLA-4 inhibitory molecule on CD4+CD25+ T cells in HTLV-I associated myelopathy (HAM/TSP)2007
- Author(s)
  Yamano Y., et.al.
- Organizer
  The 13^<th> International conference on Human Retrovirology : HTLV-I and RelatedViruses
- Place of Presentation
  箱根
- Year and Date
  2007-05-23
- Data Source
  KAKENHI-PROJECT-19591015
[Presentation] HAM患者登録システム「HAMねっと」を用いた疫学的解析.
- Author(s)
  山野嘉久, 木村美也子, 八木下尚子, 鈴木弘子, 石川美穂, 小池美佳子, 齊藤祐美, 新谷奈津美, 佐藤知雄, 高田礼子.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1関連脊髄症(HAM)患者登録システム「HAMねっと」の患者満足度調査.
- Author(s)
  八木下尚子, 有福厚孝, 菊池崇之, 木村未祐奈, 佐藤健太郎, 石川美穂, 鈴木弘子, 小池美佳子, 齊藤祐美, 新谷奈津美, 佐藤知雄, 木村美也子, 高田礼子, 山野嘉久.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Quantitative membrane proteome profiling to discover therapeutic targets for adult T-cell leukemia (ATL).
- Author(s)
  Ishihara M, Araya N, Sato T, Fujii R, Tatsuguchi A, Saichi N, Nakagawa H, Yamano Y, Ueda K.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego, USA.
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 難病研究資源バンクにおける収集試料のHLAタイピング実施による難病研究の推進.
- Author(s)
  夛田まや子, 平田誠, 佐々木光穂, 樋野村亜希子, 前畑みどり, 高橋一朗, 増井徹, 山野嘉久, 吉良潤一, 米田悦啓, 坂手龍一.
- Organizer
  第23回日本組織適合性学会大会
- Place of Presentation
  長崎県（長崎市）〔長崎大学坂本キャンパス〕
- Year and Date
  2014-09-13 – 2014-09-15
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1関連脊髄症（HAM）の臨床的評価指標の有用性に関する検討.
- Author(s)
  佐藤知雄, 井上永介, 新谷奈津美, 高橋克典, 國友康夫, Ariella Coler-Reilly, 山内淳司,　八木下尚子,　山野嘉久.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] The role of E3 ubiquitin ligase Synoviolin in bone destruction of rheumatoid arthritis.
- Author(s)
  Yagishita N, Aratani S, Fujita H, Yamano Y, Nishioka K, Nakajima T.
- Organizer
  第58回日本リウマチ学会総会・学術集会
- Place of Presentation
  東京都（港区）〔グランドプリンスホテル新高輪〕
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] The functions of the post-translational modifications in rheumatoid arthritis
- Author(s)
  Aratani S, Yagishita N, Kanazawa T, Nakajima F, Yamano Y, Nishioka K, Nakajima T
- Organizer
  1st Bio-Rheumatology International Congress(BRIC) Tokyo/The 8th GARN Meeting
- Place of Presentation
  Tokyo, Japan(Hilton Tokyo Bay Hotel)
- Data Source
  KAKENHI-PROJECT-20249052
[Presentation] HAMにおける抗CCR4抗体療法の有用性およびCCR4+CD8+T細胞の異常に関する検討.
- Author(s)
  山内淳司, 新谷奈津美,　安藤仁, 國友康夫, 高橋克典, Ariella Coler-Reilly, 八木下尚子,　佐藤知雄, 宇都宮與, 山野嘉久.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1キャリアに合併した関節リウマチに対する生物学的製剤の使用でHTLV-1ぶどう膜炎とHTLV-1関連脊髄症が悪化した1例.
- Author(s)
  寺田裕紀子, 鴨居功樹, 山野ちなみ, 山野嘉久.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HAMの歩行不安定症に対する歩行改善プログラムに関する検討.
- Author(s)
  遠藤寿子, 中島孝, 池田哲彦,　大田健太郎, 會田泉, 米持洋介, 山野嘉久.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HTLV-1によるHTLV-1関連脊髄症（HAM）病原性T細胞の発生機構の解析.
- Author(s)
  新谷奈津美, 佐藤知雄, 安藤仁, 外丸詩野, Ariella Coler-Reilly, 八木下尚子, 山内淳司, 長谷川温彦, 神奈木真理, 田中勇悦, 宇都宮與, 山野嘉久.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] CD4陽性T細胞を用いた膜プロテオーム解析によるHTLV-1関連脊髄症に対する新規治療標的分子の探索.
- Author(s)
  石原誠人, 新谷奈津美,　佐藤知雄,　藤井理沙, 最知直美, 宇都宮與, 山野嘉久, 菅野純夫,　植田幸嗣.
- Organizer
  第1回日本HTLV-1学会学術集会
- Place of Presentation
  東京都（港区）〔東京大学医科学研究所〕
- Year and Date
  2014-08-22 – 2014-08-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] 患者QOLの改善に向けた患者レジストリの満足度調査.
- Author(s)
  菊池崇之, 有福厚孝, 木村未祐奈, 佐藤健太郎, 本橋隆子, 木村美也子, 網中雅仁, 高田礼子, 八木下尚子, 山野嘉久.
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡県（福岡市）〔福岡国際会議場〕
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HAMにおけるTh1様異常T細胞の発生機構および病態への関与
- Author(s)
  佐藤知雄、新谷奈津美、安藤仁、山内淳司、國友康夫、高橋克典、斎藤祐美、石川美穂、八木下尚子、山野嘉久.
- Organizer
  第19回日本神経感染症学会総会学術集会・第26回日本神経免疫学会学術集会合同学術集会
- Place of Presentation
  石川県（金沢市）〔金沢歌劇座〕
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] HAM病態研究の進歩に基づく新規治療薬の可能性
- Author(s)
  山野嘉久
- Organizer
  第10会HAM治療研究会
- Place of Presentation
  ホテルグランヴィア大阪（大阪大阪市）
- Invited
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] HAMの炎症慢性化におけるastrocyteを介した炎症悪性ループの重要性.
- Author(s)
  山野嘉久.
- Organizer
  第55回日本神経学会学術大会
- Place of Presentation
  福岡県（福岡市）〔福岡国際会議場〕
- Year and Date
  2014-05-21 – 2014-05-24
- Data Source
  KAKENHI-PROJECT-25461294
[Presentation] Search for a model of drug efficacy for a rare chronic progressive neurological disease HAM/TSP.
- Author(s)
  Yamano Y.
- Organizer
  The 3rd International Symposium of Early Stage Clinical Trial
- Place of Presentation
  県民共済みらいホール（神奈川県横浜市）
- Invited
- Data Source
  KAKENHI-PROJECT-22590943
[Presentation] Importance of E3 ubiquitin ligase Synoviolin in fibrogenesis
- Author(s)
  Yagishita N, Hasegawa D, Aratani S, Yamano Y, Nakajima T
- Organizer
  1st Bio-Rheumatology International Congress(BRIC) Tokyo/The 8th GARN Meeting
- Place of Presentation
  Tokyo, Japan(Hilton Tokyo Bay Hotel)
- Data Source
  KAKENHI-PROJECT-20249052
[Presentation] HAMにおける抗CCR4抗体療法の有用性およびCCR4+CD8+T細胞の異常に関する検討.
- Author(s)
  山内淳司, 新谷奈津美, 安藤仁, Ariella Coler-Reilly, 國友康夫, 高橋克典, 八木下尚子, 佐藤知雄, 宇都宮與, 山野嘉久.
- Organizer
  第19回日本神経感染症学会総会学術集会・第26回日本神経免疫学会学術集会合同学術集会
- Place of Presentation
  石川県（金沢市）〔金沢歌劇座〕
- Year and Date
  2014-09-04 – 2014-09-06
- Data Source
  KAKENHI-PROJECT-25461294

1. NAKAJIMA Toshihiro (90260752)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
2. ARATANI Satoko (40387064)

# of Collaborated Projects: 3 results

# of Collaborated Products: 17 results
3. MARUYAMA Ikuro (20082282)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
4. OKADA Hidechika (30160683)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. AKATSU Hiroyasu (00399734)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YAGISHITA Naoko (40367389)

# of Collaborated Projects: 3 results

# of Collaborated Products: 26 results
7. SATO Tomoo (30387063)

# of Collaborated Projects: 2 results

# of Collaborated Products: 16 results
8. 山岸誠 (90625261)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
9. HIGUCHI Ituro (80183573)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. KAWAHARA Koichi (10381170)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
11. KAMI Masahiro (50422423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
12. TOMARU Utano (20360901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
13. FUJII Ryoji (10333535)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. KOMATSU Rie (80517475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. MISU Tatsuro (00396491)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 久保田龍二 (70336337)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. 有村公良 (20159510)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ARAYA Natsumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 15 results
19. TANAKA Hideo

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
20. ITO Hidemi

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
21. KITA Yoshikuni

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. UEDA Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
23. KATO Koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. FUJITA Hidetoshi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. MIURA Kiyonori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. HASEGAWA Hiroo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
27. SAITO Mineki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
28. 西順一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 5 results
29. 高橋悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
30. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
31. 田中恵太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
32. 田中祐吉

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
33. 田中勇悦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 石原誠人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 長谷川温彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 森満

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 加藤秀樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 神奈木真理

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
39. 伊藤隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 須藤カツ子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
41. 湯沢賢治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
42. 今井浩三

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 清水潤

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
44. 海田賢一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
45. 岩永正子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
46. 内丸薫

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
47. 渡辺俊樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 佐々木大介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
49. 渡辺能行

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 松尾恵太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
51. 松岡雅雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 吉田稔

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 水上拓郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YAMANO Yoshihisa 山野 嘉久

Research Projects

Research Products

Co-Researchers

HAMのHTLV-1感染細胞の異常形質を規定するゲノム・エピゲノム制御機構の解析Principal InvestigatorOngoing

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Integrative analysis of epigenome abnormality in the pathogenesis of HTLV-1-associated myelopathy.Principal Investigator

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Analysis of newly identified pathogenic CD4+ helper T-cells in patients with HTLV-1-associated myelopathyPrincipal Investigator

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Development of regenerative medicine for spinal cord injury in HTLV-1 associated myelopathyPrincipal Investigator

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Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.

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二元的アポトーシス制御因子シノビオリンを標的としたがん研究

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シノビオリンの二方向性シグナル制御の生物学的意義

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Integrated study on implication of Synoviolin in multiprocesses of rheumatoid arthritis.

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The development of a novel molecular targeting therapeutic intervention in HTLV-1-associated myelopathy(HAM)Principal Investigator

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[Book] 神経関連感染症 最新医学 別冊2014

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[Book] すべての内科医が知っておきたい神経疾患の診かた、考え方とその対応2013

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[Book] HAM(HTLV-1 関連脊髄症). すべての内科医が知っておきたい神経疾患の診かた、考え方とその対応2013

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[Book] Host Immune System Abnormalities Among Patients with HumanT-Lymphotropic Virus Type 1 (HTLV-1)-Associated Disorders.2011

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[Book] HTLV-1 infected CD4+CD25+CCR4+T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease. Immunologic signatures of Rejection2010

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[Book] HTLV-1 infected CD4+CD25+CCR4+T-cells disregulate balance of inflammation and tolerance in HTLV-1 associated neuroinflammatory disease.2010

YAMANO Yoshihisa 山野嘉久

[Book] 神経関連感染症　最新医学　別冊2014

[Journal Article] HTLV-1関連脊髄症―病態解明と治療の最新情報はじめに.2018