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KUBOTA Ryuji  久保田 龍二

Researcher Number 70336337
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-4158-3471
Affiliation (Current) 2022: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 教授
Affiliation (based on the past Project Information) *help 2022: 鹿児島大学, 医歯学域ヒトレトロウイルス学系, 教授
2019 – 2021: 鹿児島大学, 総合科学域総合研究学系, 教授
2016 – 2018: 鹿児島大学, 医歯学域医学系, 教授
2016: 鹿児島大学, 医歯学域 医学系, 教授
2014 – 2016: 鹿児島大学, 医歯学域医学系, 准教授 … More
2014: 鹿児島大学, 医歯学総合研究科, 准教授
2012 – 2014: 鹿児島大学, 医歯(薬)学総合研究科, 准教授
2007 – 2009: 鹿児島大学, 大学院・医歯学総合研究科, 准教授
2007: 鹿児島大学, 医歯(薬)学総合研究科, 准教授
2005 – 2006: 鹿児島大学, 大学院医歯学総合研究科, 助教授
2004: Kagoshima University, Graduate School of Medical and Dental Sciences, Associate Professor, 大学院・医歯学総合研究科, 助教授
2003: Kagoshima University, Faculty of Medicine, Associate professor, 医学部, 助教授
2002: 鹿児島大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Neurology / Neurology / Virology / Basic Section 52020:Neurology-related / Basic Section 54030:Infectious disease medicine-related
Except Principal Investigator
Neurology / Virology / Neurology / Hematology / Ophthalmology
Keywords
Principal Investigator
HTLV-1 / HAM / 細胞傷害性Tリンパ球 / ウイルス / 感染症 / HTLV-I / 細胞傷害性Tリンパ球(CTL) / 抗原 / HLA多量体 / 細胞増殖 … More / 副刺激分子 / 免疫療法 / HLA / 抗原複合体 / 動物モデル / 動物 / HTLV-I関連脊髄症 / 変異ウイルス / 同義置換 / 非同義置換 / HTLV-I関連脊髄症(HAM) / HTLV-I-associated myelopathy / cytotoxic T lymphocyte / mutant virus / viral evolution / China / Taiwan / Japan / HTLV-1 subtype / 日本 / 中国 / 台湾 / infected cell / HTLV-1 HAM / 感染細胞 / 治療法開発 / innate immunity / NKT / TLR … More
Except Principal Investigator
HAM / HTLV-1 / HTLV-I / CTL / 細胞傷害性Tリンパ球 / 宿主因子 / Shh / Gli2 / RT-PCR / フローサイトメーター / 発症規定因子 / ウイルス変異 / 宿主要因 / ウイルス量 / 分子進化 / アミノ酸置換 / 中枢神経組織 / 細胞障害性Tリンパ球 / ペプチド / MHC多量体 / HIV-1 / TSP / エイズ脳症 / 発症病態 / 治療法 / HAM-TSP / 神経病態免疫学 / CD4+CD25+CCR4+ / FoxP3 / CTLA-4 / Interferon-γ / interleukin-2 / Interleukin-17 / CD4+CD25+ / CD28 / interferon-gamma / 国際研究者交流 / 中国福建省 / HTLV-1関連脊髄症 / 成人T細胞白血病・リンパ腫 / 脳神経疾患 / 疫学 / 神経病理学 / ウイルス / 認知障害 / 神経免疫学 / HTLV-Iプロウイルス量 / 治療開発 / 発症予測 / 選択的MMP阻害剤 / 疾患感受性遺伝子 / 予後判定 / dN / dS比 / 治療薬開発 / 高齢発症 / MMP / MMP阻害剤 / HTLM-Iプロウイルス量 / HTLV-I-associated myelopathy / HTLV-I proviral load / Therapy / Prognosis / metalloproteinase inhibitor / susceptible genes / cytotoxic T lymphocytes / ワクチン / Tax / HBZ / ペプチドワクチン / uveitis / adult T cell leukemia / HAM/TSP / ぶどう膜炎 / 成人T細胞白血病 Less
  • Research Projects

    (15 results)
  • Research Products

    (130 results)
  • Co-Researchers

    (36 People)
  •  HTLV-1関連脊髄症(HAM)の自然免疫解析による病態解明と新規治療研究Principal Investigator

    • Principal Investigator
      久保田 龍二
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54030:Infectious disease medicine-related
    • Research Institution
      Kagoshima University
  •  Development of a new treatment for HAM/TSP targeting HTLV-1-infected cellsPrincipal Investigator

    • Principal Investigator
      Kubota Ryuji
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Kagoshima University
  •  A comparative study of HTLV-1-associated diseases among Fujian province in China, Taiwan, and southwest Japan.Principal Investigator

    • Principal Investigator
      Kubota Ryuji
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Kagoshima University
  •  HTLV-1関連眼疾患の診断法確立のための臨床的研究

    • Principal Investigator
      中尾 久美子
    • Project Period (FY)
      2016 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Ophthalmology
    • Research Institution
      Kagoshima University
  •  Development of HTLV-1 peptide vaccine for treatment and prevention of ATL

    • Principal Investigator
      Arima Naomichi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Kagoshima University
  •  Comparable studies on HTLV-1 associated diseases between costal area of Fujian province, China, and south-western Japan.

    • Principal Investigator
      Izumo Shuji
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      Kagoshima University
  •  Molecular pathologic study on pathogenesis of HIV-associated neurocognitive disorders (HANDs)

    • Principal Investigator
      IZUMO Syuji
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  An attempt to develop an animal model of HAM/TSPPrincipal Investigator

    • Principal Investigator
      KUBOTA Ryuji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Neuropathogenesis of retrovirus infection : diverse in vivo and ex vivo analysis of HAM/TSP and AIDS encephalopathy.

    • Principal Investigator
      IZUMO Shuji
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  The development of a novel molecular targeting therapeutic intervention in HTLV-1-associated myelopathy(HAM)

    • Principal Investigator
      YAMANO Yoshihisa
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      St.Marianna University School of Medicine
  •  中枢神経組織におけるウイルス特異的細胞傷害性Tリンパ球の検出

    • Principal Investigator
      OSAME Mitsuhiro
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  テトラマーを用いた細胞傷害性Tリンパ球の刺激法の開発Principal Investigator

    • Principal Investigator
      久保田 龍二
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  T細胞増殖関連Sonic Hedgehog分子とHAM患者ウイルス抑制機構の研究

    • Principal Investigator
      USUKU Koichiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Exploitation of new therapies for HTLV-I-assotiated myelopathy

    • Principal Investigator
      OSAME Mitsuhiro
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University
  •  Cytotoxic T lymphocytes and viral mutations in HTLV-I-associated myelopathyPrincipal Investigator

    • Principal Investigator
      KUBOTA Ryuji
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Kagoshima University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2010 2009 2008 2007 2003 Other

All Journal Article Presentation Book

  • [Book] HTLV-1関連脊髄症(HAM)診療ガイドライン20192019

    • Author(s)
      久保田龍二
    • Total Pages
      211
    • Publisher
      南江堂
    • ISBN
      9784524226344
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Book] 神経疾患 最新の治療 2015-2017。小林祥泰/水澤英洋/山口修平 編集。ヒトTリンパ球向性ウイルス脊髄症(HAM)2015

    • Author(s)
      久保田龍二
    • Total Pages
      3
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Book] ヒトTリンパ球向性ウイルス脊髄症(HAM)。神経疾患 最新の治療 2015-20172015

    • Author(s)
      久保田龍二
    • Total Pages
      3
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Book] ヒトTリンパ球向性ウイルス脊髄症(HAM)。神経疾患 最新の治療 2015-20172014

    • Author(s)
      久保田龍二
    • Total Pages
      4
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Book] HTLV-1関連脊髄症(HAM)。免疫性神経疾患ハンドブック2013

    • Author(s)
      久保田龍二、出雲周二
    • Total Pages
      15
    • Publisher
      南江堂
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Book] HTLV-1。神経症候群I2013

    • Author(s)
      久保田龍二
    • Total Pages
      5
    • Publisher
      日本臨床社
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Journal Article] Anti-human T-cell leukemia virus type 1 (HTLV-1) antibody assays in cerebrospinal fluid for the diagnosis of HTLV-1-associated myelopathy/tropical spastic paraparesis.2021

    • Author(s)
      Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Nozuma Satoshi, Matsuura Eiji, Takashima Hiroshi, Izumo Shuji, Kubota Ryuji
    • Journal Title

      J Clin Microbiol

      Volume: -

    • DOI

      10.1128/jcm.03230-20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-20K22879, KAKENHI-PROJECT-16K11268
  • [Journal Article] Inhibition of ABL1 tyrosine kinase reduces HTLV-1 proviral loads in peripheral blood mononuclear cells from patients with HTLV-1-associated myelopathy/tropical spastic paraparesis2020

    • Author(s)
      Kodama Daisuke, Tanaka Masakazu, Matsuzaki Toshio, Izumo Kimiko, Nakano Nobuaki, Matsuura Eiji, Saito Mineki, Nagai Masahiro, Horiuchi Masahisa, Utsunomiya Atae, Takashima Hiroshi, Kubota Ryuji, Izumo Shuji
    • Journal Title

      PLOS Neglected Tropical Diseases

      Volume: 14

    • DOI

      10.1371/journal.pntd.0008361

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-18K07541
  • [Journal Article] Establishment of a novel diagnostic test algorithm for human T-cell leukemia virus type 1 infection with line immunoassay replacement of western blotting : a collaborative study for performance evaluation of diagnostic assays in Japan.2020

    • Author(s)
      Kazu Okuma, Isao Hamaguchi, Isao Hamaguchi, Yasuko Sagara, Hitomi Nakamura, et al.
    • Journal Title

      Retrovirology

      Volume: 17 Issue: 1 Pages: 1-12

    • DOI

      10.1186/s12977-020-00534-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07983, KAKENHI-PROJECT-19K07999, KAKENHI-PROJECT-20K07670, KAKENHI-PROJECT-19K16032, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-19K16580, KAKENHI-PROJECT-16H06277
  • [Journal Article] Expression of TSLC1 in patients with HAM/TSP2020

    • Author(s)
      Takenouchi N, Tanaka M, Sato T, Yao J, Fujisawa JI, Izumo S, Kubota R, Matsuura E.
    • Journal Title

      Journal of NeuroVirology

      Volume: 26 Pages: 404-414

    • DOI

      10.1007/s13365-020-00838-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K11268, KAKENHI-PROJECT-19K07999
  • [Journal Article] Human T-lymphotropic virus type 1 (HTLV-1) and cellular immune response in HTLV-1-associated myelopathy/tropical spastic paraparesis2020

    • Author(s)
      Nozuma S, Kubota R, Jacobson S
    • Journal Title

      Journal of NeuroVirology

      Volume: 26 Pages: 652-663

    • DOI

      10.1007/s13365-020-00881-w

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K11268, KAKENHI-PROJECT-19K07999
  • [Journal Article] Multiple spotty lesions of the spinal cord in a Chinese patient with human T-lymphotropic virus type-1-associated myelopathy/tropical spastic paraparesis.2018

    • Author(s)
      Gao H、Ye X、Cai R、Xu Q、Liang L、Izumo S、Xing HQ、Kubota R
    • Journal Title

      Int J Infect Dis.

      Volume: 68 Pages: 1-3

    • DOI

      10.1016/j.ijid.2017.12.022

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Journal Article] HAMの臨床像と発症病理2018

    • Author(s)
      久保田龍二
    • Journal Title

      医学のあゆみ

      Volume: 267 Pages: 737-740

    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Journal Article] Value assignment of the reference material for human T-cell leukemia virus type l quantitative PCR in Japan2018

    • Author(s)
      Madoka Kuramitsu, Kaoru Uchimaru, Yasuko Sagara, Toshiki Watanabe, Isao Hamaguchi, et al.
    • Journal Title

      Microbiol Immunol

      Volume: 62 Issue: 10 Pages: 673-676

    • DOI

      10.1111/1348-0421.12644

    • NAID

      40021702629

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-18K08378, KAKENHI-PROJECT-16H05248, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-18H02733, KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-16H06277
  • [Journal Article] Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis2017

    • Author(s)
      Nozuma S, Matsuura E, Kodama D, Tashiro Y, Matsuzaki T, Kubota R, Izumo S, Takashima H
    • Journal Title

      Retrovirology

      Volume: 14 Pages: 26-26

    • DOI

      10.1186/s12977-017-0350-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11268, KAKENHI-PROJECT-16H05823
  • [Journal Article] HTLV-I関連脊髄症(HAM)2017

    • Author(s)
      松浦英治、久保田龍二
    • Journal Title

      Clinical Neuroscience

      Volume: 35 Pages: 1474-5

    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Journal Article] Pathogenesis of HTLV-1-associated myelopathy/tropical spastic paraparesis2017

    • Author(s)
      Kubota R
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 8

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Journal Article] Pathogenesis of human T-Lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis2017

    • Author(s)
      Kubota R
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 8 Pages: 117-128

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Journal Article] Proviral features of human T Cell leukemia virus type I in carriors with indeterminate western blot analysis results2017

    • Author(s)
      Kuramitsu M, Sekizuka T, Watanabe T, Okuma K, Hamaguchi I and et al.
    • Journal Title

      J Clin Microbiol

      Volume: 55(9) Pages: 2838-2849

    • DOI

      10.1128/jcm.00659-17

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K09702, KAKENHI-PROJECT-17K11241, KAKENHI-PROJECT-17K15044, KAKENHI-PROJECT-16H05323, KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-17H03594, KAKENHI-PROJECT-15K08647, KAKENHI-PROJECT-15K09462, KAKENHI-PROJECT-15K14388, KAKENHI-PROJECT-16H06277
  • [Journal Article] HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): A comparative study to identify factors that influence disease progression.2016

    • Author(s)
      Matsuura E, Nozuma S, Tashiro Y, Kubota R, Izumo S, Takashima H
    • Journal Title

      J Neurol Sci

      Volume: 371 Pages: 112-116

    • DOI

      10.1016/j.jns.2016.10.030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05823, KAKENHI-PROJECT-25305017, KAKENHI-PROJECT-16K11268
  • [Journal Article] Clinical presentation of axial myopathy in two siblings with HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP).2015

    • Author(s)
      Matsuura E, Yoshimura A, Nozuma S, Higuchi I, Kubota R, Takashima H
    • Journal Title

      BMC Neurol.

      Volume: 15 Pages: 18-18

    • DOI

      10.1186/s12883-015-0275-7

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Journal Article] Visualization of HTLV-1-specific cytotoxic T lymphocytes in the spinal cords of patients with HTLV-1-associated myelopathy/tropical spastic paraparesis2015

    • Author(s)
      Matsuura E, Kubota R, Tanaka Y, Takashima H, Izumo S
    • Journal Title

      J Neuropathol Exp Neurol

      Volume: 74 Issue: 1 Pages: 2-14

    • DOI

      10.1097/nen.0000000000000141

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591271, KAKENHI-PROJECT-25305017, KAKENHI-PROJECT-221S0001
  • [Journal Article] Familial clusters of HTLV-1-associated myelopathy/tropical spastic paraparesis2014

    • Author(s)
      Nozuma S, Matsuura E, Matsuzaki T, Watanabe O, Kubota R, Izumo S, Takashima H
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0086144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591271, KAKENHI-PROJECT-25305017
  • [Journal Article] HAMスペクトラム2012

    • Author(s)
      久保田龍二
    • Journal Title

      神経内科

      Volume: 77 Pages: 283-288

    • Data Source
      KAKENHI-PROJECT-24591271
  • [Journal Article] Human T-lymphotropic virus type I (HTLV-I)-specific CD8+ cells accumulate in the lungs of patients infected with HTLV-I with pulmonary involvement2012

    • Author(s)
      Kawabata T, Higashimoto I, Takashima H, Izumo S, Kubota R
    • Journal Title

      J Med Virol

      Volume: 84 Pages: 1120-1127

    • DOI

      10.1002/jmv.23307

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Journal Article] Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis.2009

    • Author(s)
      Xing HQ, Hayakawa H, Gelpi E, Kubota R, Budka H, Izumo S
    • Journal Title

      J Neuropathol Exp Neurol 68

      Pages: 199-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] In vivo expression of proinflammatory cytokines in HIV encephalitis: an analysis of 11 autopsy cases.2009

    • Author(s)
      Xing HQ, Hayakawa H, Izumo K, Kubota R, Gelpi E, Budka H, Izumo S
    • Journal Title

      Neuropathology 29

      Pages: 433-442

    • NAID

      10028191694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] Reduced expression of excitatory amino acid transporter 2 and diffuse microglial activation in the cerebral cortex in AIDS cases with or without HIV encephalitis2009

    • Author(s)
      Xing HQ, Hayakawa H, Gelpi E, Kubota R, Budka H, Izumo S
    • Journal Title

      J Neuropath Exp Neurol. 68(2)

      Pages: 199-209

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] In vivo expression of proinflammatory cytokines in HIV encephalitis : an analysis of 11 autopsy cases2009

    • Author(s)
      Xing HQ, Hayakawa H, Izumo K, Kubota R, Gelpi E, Budka H, Izumo S
    • Journal Title

      Neuropathology. 29(4)

      Pages: 433-442

    • NAID

      10028191694

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] Inclusion body myositis associated with human T-lymphotropic virus-type I infection: eleven patients from an endemic area in Japan.2008

    • Author(s)
      Matsuura E, Umehara F, Nose H, Higuchi I, Matsuoka E, Izumi K, Kubota R, Saito M, Izumo S, Arimura K, Osame M
    • Journal Title

      J Neuropathol Exp Neurol 67

      Pages: 41-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] Reduced Foxp3 expression with increased cytomegalovirus-specific CTL in HTLV-I-associated myelopathy.2008

    • Author(s)
      Hayashi D, Kubota R, Takenouchi N, Tanaka Y, Hirano R, Takashima H, Osame M, Izumo S, Arimura K
    • Journal Title

      J Neuroimmunol 200

      Pages: 115-124

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs.2007

    • Author(s)
      Kubota R, Hanada K, Furukawa Y, Arimura K, Osame M, Gojobori T, Izumo S
    • Journal Title

      J Immunol 178

      Pages: 5966-5972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] Genetic stability of human T lymphotropic virus type I despite antiviral pressures by CTLs.2007

    • Author(s)
      Kubota R
    • Journal Title

      J Immunol 178

      Pages: 5966-5972

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Journal Article] Degenerate specificity of HTLV-1-specific CD8+ T cells during viral replication in patients with HTLV-1-associated myelopathy (HAM/TSP).2003

    • Author(s)
      Kubota R, et al.
    • Journal Title

      Blood 101(8)

      Pages: 3074-3081

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14207031
  • [Journal Article] Degenerate specificity of HTLV-I-specific CD8+ T cells during viral replication in patients with HTLV-I-associated myelopathy (HAM/TSP)2003

    • Author(s)
      Kubota R, et al.
    • Journal Title

      Blood 101(8)

      Pages: 3074-3081

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14207031
  • [Presentation] 髄液中抗HTLV-1抗体検査とHAM診断2021

    • Author(s)
      児玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋博、出雲周二、久保田龍二
    • Organizer
      第7回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Immunopathogenic CSF TCR repertoire signatures in virus-induced neurologic disease.2021

    • Author(s)
      野妻智嗣、松浦英治、田中正和、久保田龍二、Steven Jacobson、高嶋博
    • Organizer
      第62回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] HTLV-1感染細胞を標的としたTCRレパトア解析によるHAMの病勢指標となるバイオマーカーの探索2021

    • Author(s)
      野妻智嗣、松浦英治、田中正和、松崎敏男、久保田龍二、高嶋博
    • Organizer
      第7回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] HAM患者HTLV-1感染CD4+T細胞におけるTCRシグナルの低下2021

    • Author(s)
      久保田龍二、田中正和、児玉大介、野妻智嗣、松浦英治、田中勇悦、高嶋博
    • Organizer
      第7回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] HAM疾患活動性バイオマーカーとしてのCADM1の検討2021

    • Author(s)
      竹之内徳博、田中正和、松浦英治、久保田龍二、中嶋伸介、大高時文、上野孝治、大隈和
    • Organizer
      第7回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Integrated mRNA and microRNA analysis of HTLV-1-infected cells from HAM patients.2021

    • Author(s)
      久保田龍二、野妻智嗣、田中正和、松浦英治、高嶋博
    • Organizer
      第62回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Retrieval of therapeutic target molecules for HAM by microarray analysis of HTLV-1-infected cells.2020

    • Author(s)
      久保田龍二、田中正和、松浦英治、高嶋 博
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] N-acetyllactosamine impacts on the infectivity of HTLV-1.2020

    • Author(s)
      児玉大介、田中正和、出雲公子、松﨑敏男、松浦英治、高嶋博、出雲周二、久保田龍二
    • Organizer
      第32回日本神経免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] High reactivity to anti-HERV-K10 in HTLV-1-infected individuals.2020

    • Author(s)
      児玉大介、田中正和、松崎敏男、野妻智嗣、松浦英治、高嶋 博、出雲周二、久保田龍二
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease.2020

    • Author(s)
      野妻智嗣、松浦英治、田中正和、松崎敏男、久保田龍二、Steven Jacobson、高嶋 博
    • Organizer
      第61回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] 鹿児島県霧島市でのキャリアママの会カランコエかごしまによるHTLV 1 キャリア相談事業2019

    • Author(s)
      松﨑敏男、池上真弓、久保田龍二
    • Organizer
      第6回日本HTLV-1学会,宮崎
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Inhibition of ABL1 induces decrease of proviral load HTLV-1 infected CD4+ T cell of HAM/TSP.2019

    • Author(s)
      D. Kodama, M. Tanaka, T. Matsuzaki, H. Takashima, S. Izumo, R. Kubota.
    • Organizer
      19th International Conference on Human Retrovirology: HTLV & Related Viruses,Lima, Peru.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] HAM患者HTLV-1感染細胞のマイクロアレイ解析による治療標的分子の探索2019

    • Author(s)
      久保田龍二、田中正和、春口志門、児玉大介、松浦英治、高嶋 博
    • Organizer
      第6回日本HTLV-1学会,宮崎
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Microarray analysis reveals down-regulation of Toll-like receptor genes in activated HTLV-1-infected cells from patients with HTLV-1-associated neurological disease.2019

    • Author(s)
      R. Kubota, M. Tanaka, D. Kodama, E. Matsuura, H. Takashima.
    • Organizer
      52th Annual Meeting of the Society for Leukocyte Biology. Boston.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] HAM 患者 HTLV-1 感染細胞のマイクロアレイ解析による治療標的分子の探索2019

    • Author(s)
      久保田 龍二、田中 正和、春口 志門、児玉 大介、松浦 英治、高嶋 博
    • Organizer
      第6回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K11268
  • [Presentation] Microarray analysis reveals down-regulation of Toll-like receptor genes in activated HTLV-1-infected cells from HAM/TSP patients.2019

    • Author(s)
      R. Kubota, M. Tanaka, D. Kodama, E. Matsuura, H. Takashima.
    • Organizer
      19th International Conference on Human Retrovirology: HTLV & Related Viruses,Lima, Peru.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Effect of neuraminidase inhibitors on HTLV-1 infection and lymphocyte chemotaxis in HAM/TSP.2019

    • Author(s)
      M. Tanaka, D. Kodama, E. Matsuura, H. Takashima, S. Izumo, R. Kubota.
    • Organizer
      19th International Conference on Human Retrovirology: HTLV & Related Viruses,Lima, Peru.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] HAM: the inflammatory neurological disease caused by HTLV-12019

    • Author(s)
      R. Kubota
    • Organizer
      4th Precision Medicine Conference in Fujian, China.
    • Invited
    • Data Source
      KAKENHI-PROJECT-19K07999
  • [Presentation] Inhibition of survival gene ABL1 dramatically decreases HTLV-1 infected CD4+ T cells in HAM/TSP.2018

    • Author(s)
      児玉大介、松崎敏男、田中正和、松浦英治、高嶋 博、久保田龍二、出雲周二
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HTLV-1関連細胞株と成人T細胞白血病/リンパ腫(ATL)に於けるサバイビンの抗原回復免疫組織化学2018

    • Author(s)
      蓮井和久、佐藤榮一、宇都宮與、木脇祐俊、満田稔、斎藤稔、原博満、久保田龍二、出雲周二
    • Organizer
      第5回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HTLV-1感染におけるノイラミニダーゼ阻害効果について2018

    • Author(s)
      田中正和、兒玉大介、松浦英治、高嶋博、久保田龍二
    • Organizer
      第71回日本細菌学会九州支部総会・第55回日本ウイルス学会九州支部総会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HTLV-1で起こる神経難病:HAM2018

    • Author(s)
      久保田龍二
    • Organizer
      日本学術会議九州・沖縄地区学術講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Clinical experiemce of human amniotic epithelial cells transplantation in a Chinese HAM/TSP patient.2018

    • Author(s)
      高宏志、ケイ惠琴、久保田龍二
    • Organizer
      第5回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HTLV-1定量PCRの標準化のための参照品の作製2018

    • Author(s)
      倉光球、大隈和、内丸薫、山野嘉久、長谷川寛雄、野坂生郷、岡山昭彦、久保田龍二、佐竹正博、金子紀章、渡邉俊樹、浜口 功
    • Organizer
      第5回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM患者由来HTLV-1感染細胞のウイルス活性化によるToll様受容体の発現低下2018

    • Author(s)
      久保田龍二、児玉大介、田中正和、松浦英治、高嶋 博
    • Organizer
      第5回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HTLV-1 reduces the expression of Toll-like receptor genes in HAM/TSP patients.2018

    • Author(s)
      久保田龍二、児玉大介、田中正和、高嶋 博
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM患者に対するL-アルギニン内服治療の試み。第59回日本神経学会学術大会2018

    • Author(s)
      田代雄一、松浦英治、橋口昭大、中村友紀、野妻智嗣、松崎敏男、児玉大介、田中正和、久保田龍二、高嶋 博
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] The effects of neuraminidase inhibitors on HTLV-1 infection and lymphocyte chemotaxis in HAM/TSP.2018

    • Author(s)
      田中正和、児玉大介、松浦英治、高嶋 博、久保田龍二
    • Organizer
      第59回日本神経学会学術大会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM: the intractable neurological disease caused by HTLV-1.2018

    • Author(s)
      Kubota R
    • Organizer
      3rd Precision Medicine Conference in Fujian, China
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Sequence analysis identified an HTLV-1 subtype and mutations of host restriction factors susceptible to HTLV-1-associated myelopathy/tropical spastic paraparesis.2017

    • Author(s)
      Nozuma S, Matsuura E, Matsuzaki T, Kodama D, Kubota R, Izumo S, Takashima H
    • Organizer
      XXIII World Congress of Neurology. Kyoto, Japan, 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] ER Stress Response Induced by Inhibition of GRP94 or LacNAc synthetase B3GnT2 in CD4+T Cells of HAM/TSP2017

    • Author(s)
      Kodama D, Matsuzaki T, Takashima H, Kubota R
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses,
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Gene Expression Profile of Activated HTLV-1-Infected Cells from HAM/TSP Patients2017

    • Author(s)
      Kubota R, Kodama D, Takashima H
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Differential expression of nucleosome-related genes in Activated HTLV-1-infected cells of HAM/TSPpatients.2017

    • Author(s)
      Kubota R, Kodama D, Takashima H
    • Organizer
      XXIII World Congress of Neurology. Kyoto, Japan, 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] ABLチロシンキナーゼ阻害薬を使用したHAM合併CMLの1例2017

    • Author(s)
      松崎敏男、中野伸亮、児玉大介、齊藤峰輝、永井将弘、宇都宮興、出雲周二、久保田龍二
    • Organizer
      第4回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] The estimated number of HTLV-1 carriers in Kagoshima.2017

    • Author(s)
      Tashiro Y, Matsuura E, Sagara Y, Kubota R, Takashima H
    • Organizer
      XXIII World Congress of Neurology. Kyoto, Japan, 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] ER Stress Response Induced by Inhibition of GRP94 or LacNAc synthetase B3GnT2 in CD4+T Cells of HAM/TSP2017

    • Author(s)
      Kodama D, Matsuzaki T, Takashima H, Kubota R
    • Organizer
      18th International Conference on Human Retrovirology:
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HAM患者CD4+T細胞サバイバル遺伝子ABL1の阻害による感染細胞の劇的アポトーシス誘導2017

    • Author(s)
      児玉大介、松崎敏男、高嶋 博、久保田龍二、出雲周二
    • Organizer
      第4回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM患者CD4+T細胞サバイバル遺伝子ABL1の阻害による感染細胞の劇的アポトーシス誘導2017

    • Author(s)
      児玉大介、松崎敏男、高嶋 博、久保田龍二、出雲周二
    • Organizer
      第29回日本神経免疫学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM/TSP: clinical features and pathogenesis2017

    • Author(s)
      Kubota R
    • Organizer
      2nd Precision Medicine Conference in Fujian, Quanzhou, China. June 2017
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] 遺伝子改変マウスを用いたHAM病態モデル動物の作製2017

    • Author(s)
      後川潤、有島志保、安永純一朗、久保田龍二、大島孝一、出雲周二、松岡雅雄、齊藤峰輝
    • Organizer
      第4回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Establishment of a Novel Small Animal Model for HAM/TSP2017

    • Author(s)
      Ushirogawa H, Arishima S, Yasunaga J, Kubota R, Ohshima K, Izumo S, Matsuoka M, Saito M
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Effect of Biologic Agents on HAM/TSP with Rheumatoid Arthritis2017

    • Author(s)
      Matsuzaki T, Saito M, Yamano Y, Nagai M, Takashima H, Izumihara T, Yoshitama T, Kubota R
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] 成人T細胞白血病(ATL)の末梢血組織標本のSurvivinの抗原回復免疫組織化学による解析2017

    • Author(s)
      蓮井和久、宇都宮興、佐藤榮一、木脇祐俊、満田稔、斉藤稔、原博満、久保田龍二、出雲周二
    • Organizer
      第4回日本HTLV-1学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Estimated Number of HTLV-1 Carriers in Kagoshima2017

    • Author(s)
      Tashiro Y, Matsuura E, Sagara Y, Kubota R, Takashima H
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] 中国福健省でHAMを探す:中日共同研究2017

    • Author(s)
      ケイ惠琴、高宏志、コク肇績、叶翔、許芥平、鄭維紅、久保田龍二、出雲周二
    • Organizer
      第2回鹿児島大学感染症制御のためのシンポジウム 特別講演
    • Place of Presentation
      鹿児島大学鶴陵会館(鹿児島県鹿児島市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] Comparison of anti-HTLV-1 antibody screening tests of CLIA, CLEIA, and PA by ROC analysis using titer and logistic regression models for diagnosis of HAM/TSP2017

    • Author(s)
      Kodama D, Matsuzaki T, Takashima H, Izumo S, Kubota R
    • Organizer
      XXIII World Congress of Neurology. Kyoto, Japan, 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Probability of Re-circulation of Lymphoma Type Adult T-cell Leukemia (ATL) Cells into Peripheral Blood: An Antigen-Retrieval (AR)- Immunohistochemistry (IHC) of Stem Cell and Neoplastic Features in Lymphoma Type ATL Cells in the Involved Lymph Nodes2017

    • Author(s)
      Hasui K, Sato E, Kiwaki S, Mitsuda M, Saito M, Hara H, Kubota R, Izumo S
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Effects of Host Restriction Factors and the HTLV-1 Subtype on Susceptibility to HAM/TSP2017

    • Author(s)
      Nozuma S, Matsuura E, Matsuzaki T, Kodama D, Kubota R, Izumo S, Takashima H
    • Organizer
      18th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Gene Expression Profile of Activated HTLV-1-Infected Cells from HAM/TSP Patients2017

    • Author(s)
      Kubota R, Kodama D, Takashima H
    • Organizer
      18th International Conference on Human Retrovirology:
    • Place of Presentation
      ホテルグランドアーク半蔵門(東京都千代田区)
    • Year and Date
      2017-03-08
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HAM患者に対するアミノ酸内服治療の試み2017

    • Author(s)
      田代雄一、橋口昭大、中村友紀、野妻智嗣、松崎敏男、児玉大介、松浦英治、久保田龍二、高嶋 博
    • Organizer
      第22回日本神経感染症学会学術集会
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM患者HTLV-1感染細胞のウイルス活性化時の遺伝子変動2016

    • Author(s)
      久保田龍二、高嶋 博
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Resistance against ER stress in CD4+ T cells of HAM2016

    • Author(s)
      児玉大介、久保田龍二、松崎敏男、高嶋博、出雲周二
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM発症に関与する宿主防御因子とHTLV-1ウイルス遺伝子の解析2016

    • Author(s)
      野妻智嗣、松浦英治、松崎敏男、児玉大介、久保田龍二、出雲周二、高嶋 博
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HAM患者CD4+ T細胞へのGRP94阻害薬、N-アセチルラクトサミン合成酵素B3GnT2阻害薬による小胞体ストレス応答2016

    • Author(s)
      児玉大介、久保田龍二、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] 中国福健省でHAMを探す:中日共同研究中間報告-22016

    • Author(s)
      ケイ惠琴、高洪志、コク肇績、彭鋒、叶翔、許芥平、テイ小把、鄭維紅、久保田龍二、出雲周二
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] Gene expression profile of activated HTLV-1-infected cells from HAM patients2016

    • Author(s)
      久保田龍二、高嶋 博、出雲周二
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HAM患者CD4+ T細胞へのGRP94阻害薬、N-アセチルラクトサミン合成酵素B3GnT2阻害薬による小胞体ストレス応答2016

    • Author(s)
      児玉大介、久保田龍二、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] Gene expression profile of activated HTLV-1-infected cells from HAM patients2016

    • Author(s)
      久保田龍二、高嶋 博、出雲周二
    • Organizer
      第57回日本神経学会学術大会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] Resistance against ER stress in CD4+ T cells of HAM2016

    • Author(s)
      児玉大介、久保田龍二、松崎敏男、高嶋博、出雲周二
    • Organizer
      第57回日本神経学会学術集会
    • Place of Presentation
      神戸コンベンションセンター(兵庫県神戸市)
    • Year and Date
      2016-05-20
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HAM患者HTLV-1感染細胞のウイルス活性化時の遺伝子変動2016

    • Author(s)
      久保田龍二、高嶋 博
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] 中国福健省でHAMを探す:中日共同研究中間報告-22016

    • Author(s)
      ケイ惠琴、高洪志、コク肇績、彭鋒、叶翔、許芥平、テイ小把、鄭維紅、久保田龍二、出雲周二
    • Organizer
      第3回日本HTLV-1学会学術集会
    • Place of Presentation
      鹿児島県市町村自治会館(鹿児島県鹿児島市)
    • Year and Date
      2016-08-26
    • Data Source
      KAKENHI-PROJECT-16H05823
  • [Presentation] HTLV-1関連脊髄症(HAM)の臨床と治療2015

    • Author(s)
      久保田龍二
    • Organizer
      第4回中国・台湾合同神経内科フォーラム
    • Place of Presentation
      厦門大学附属中山医院 厦門市(中国)
    • Year and Date
      2015-12-05
    • Invited
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HAMにおけるHTLV-1 HBZ特異的CTLの検出2014

    • Author(s)
      久保田龍二、松﨑敏男、高嶋 博、出雲周二
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市(福岡国際会議場)
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HTLV-1 HBZ特異的CTLのエピトープ同定とHAMにおける検出2014

    • Author(s)
      久保田龍二、松﨑敏男、高嶋 博、出雲周二
    • Organizer
      第19回日本神経感染症学会学術集会
    • Place of Presentation
      金沢市(金沢歌劇座)
    • Year and Date
      2014-09-06
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HTLV-1 HBZ特異的CTLのエピトープ同定とHAMにおける検出2014

    • Author(s)
      久保田龍二、松﨑敏男、高嶋 博、出雲周二
    • Organizer
      第19回日本神経感染症学会学術集会
    • Place of Presentation
      金沢市(金沢歌劇座)
    • Year and Date
      2014-09-06
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HAMにおけるHTLV-1抗原遺伝子変異とCTL認識2014

    • Author(s)
      久保田龍二、齊藤峰輝、高嶋 博、出雲周二
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京都(東京大学医科学研究所)
    • Year and Date
      2014-08-24
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] HAMにおけるHTLV-1 HBZ特異的CTLの検出2014

    • Author(s)
      久保田龍二、松﨑敏男、高嶋 博、出雲周二
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市(福岡国際会議場)
    • Year and Date
      2014-05-23
    • Data Source
      KAKENHI-PROJECT-25305017
  • [Presentation] Neuropathology of retroviraus infection; Pathogenesis of HAM/TSP and AIDS dementia.2014

    • Author(s)
      Shuji Izumo, Ryuji Kubota, HuiQin Xing
    • Organizer
      第55回日本神経学会国際シンポジウム
    • Place of Presentation
      (福岡市)福岡国際会議場
    • Year and Date
      2014-05-21
    • Data Source
      KAKENHI-PROJECT-25461285
  • [Presentation] HAMにおけるHTLV-1抗原遺伝子変異とCTL認識2014

    • Author(s)
      久保田龍二、齊藤峰輝、高嶋 博、出雲周二
    • Organizer
      第1回日本HTLV-1学会学術集会
    • Place of Presentation
      東京都(東京大学医科学研究所)
    • Year and Date
      2014-08-24
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] Impaired T cell receptor signaling in HTLV-1-infected CD4+ cells from HAM/TSP patients2013

    • Author(s)
      Kubota R, Takashima H, Izumo S
    • Organizer
      16th International Conference on Human Retrovirology: HTLV & Related Viruses
    • Place of Presentation
      Montreal, Canada
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HTLV-1 HBZ特異的CTLエピトープの探索2013

    • Author(s)
      久保田龍二、高嶋 博、出雲周二
    • Organizer
      第6回HTLV-I研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HAM患者HTLV-1感染CD4+T細胞における免疫能低下2013

    • Author(s)
      久保田龍二、高嶋 博、出雲周二
    • Organizer
      第54回日本神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HLA-A*24拘束性HTLV-I特異的CTLはHAM発症リスクを下げるか?2012

    • Author(s)
      久保田龍二、竹之内徳博、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第21回日本組織適合性学会大会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HAM患者HTLV-1感染細胞における免疫反応低下2012

    • Author(s)
      久保田龍二、高嶋 博、出雲周二
    • Organizer
      第17回日本神経感染症学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HTLV-I特異的CTL機能はHAMとキャリアで異なるのか?2012

    • Author(s)
      久保田龍二、有島志保、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第24回日本神経免疫学会
    • Place of Presentation
      長野
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HAMとキャリアにおけるHTLV-I特異的CTL機能の比較検討2012

    • Author(s)
      久保田龍二、有島志保、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第53回日本神経学会総会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591271
  • [Presentation] HAM患者末梢血HTLV-I感染細胞におけるケモカインおよびFoxP3の発現2010

    • Author(s)
      久保田龍二, 林大輔, 出雲周二
    • Organizer
      第22回日本神経免疫学会学術集会
    • Place of Presentation
      日経ホール(東京都)
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-1 roles in hUPF1 expression and phosphorylation2010

    • Author(s)
      Abdelbary N, Kubota R, Usuki F, Abdulah H, Izumo S
    • Organizer
      第22回日本神経免疫学会学術集会
    • Place of Presentation
      日経ホール(東京都)
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I感染者における免疫抑制性受容体の発現2009

    • Author(s)
      吉満誠, 小迫知弘, 鈴木伸介, 松下格司, 魚住公治, 久保田龍二, 出雲周二, 有馬直道
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京大学医科学研究所(東京都)
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I関連脊髄症(HAM/TSP)におけるRNAマイクロアレイ解析による検討2009

    • Author(s)
      児玉大介, 久保田龍二, 出雲周二
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I関連脊髄症(HAM/TSP)患者末梢血単核球を用いた合胞体形成の検討2009

    • Author(s)
      児玉大介, 久保田龍二, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] Possible effect of HTLV-I on hUPF1 expression and phosphorylatior2009

    • Author(s)
      Abdelbary N, Kubota R, Usuki F, Abdulah H, Izumo S
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京大学医科学研究所(東京都)
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-Iキャリア外来の現状とHAM患者の動向について2009

    • Author(s)
      松崎敏男, 久保田龍二, 有村公良, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-21
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I associated polymyositis : a trial to unfold the story2009

    • Author(s)
      Abdulah H, Higuchi I, Kubota R, Matsuura E, Hashiguchi A, Adbelbary N, Izumo S.
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京大学医科学研究所(東京都)
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I感染者における免疫抑制性受容体の発現2009

    • Author(s)
      吉満誠, 小迫知弘, 鈴木伸介, 松下格司, 魚住公治, 久保田龍二, 出雲周二, 有馬直道
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京都
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HAM脊髄におけるHTLV-I特異的CTLとアポトーシス細胞の同定2009

    • Author(s)
      久保田龍二, 松浦英治, 有村公良, 出雲周二
    • Organizer
      第21回日本神経免疫学会
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I関連脊髄症(HAM/TSP)におけるRNAマイクロアレイ解析による検討2009

    • Author(s)
      児玉大介, 久保田龍二, 出雲周二
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京大学医科学研究所(東京都)
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-Iキャリア外来の現状とHAM患者の動向について2009

    • Author(s)
      松崎敏男, 久保田龍二, 有村公良, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2009-05-21
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I関連脊髄症(HAM/TSP)患者末梢血単核球を用いた合胞体形成の検討2009

    • Author(s)
      児玉大介, 久保田龍二, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HTLV-I関連疾患における invariant NKT細胞の量的・機能的異常2009

    • Author(s)
      佐藤知雄, 阿座上和子, 新谷奈津美, 高橋克典, 宇都宮與, 久保田龍二, 山野嘉久
    • Organizer
      第2回HTLV-I研究会
    • Place of Presentation
      東京大学医科学研究所(東京都)
    • Year and Date
      2009-08-29
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] 抗原認識特異度の低いHTLV-I特異的CTLはウイルス淘汰圧が高い2009

    • Author(s)
      久保田龍二, 松浦英治, 有村公良, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台国際センター(仙台市)
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] 抗原認識特異度の低いHTLV-I特異的CTLはウイルス淘汰圧が高い2009

    • Author(s)
      久保田龍二, 松浦英治, 有村公良, 出雲周二
    • Organizer
      第50回日本神経学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2009-05-20
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HLA-A24はHAMでは頻度が高いがウイルス量は低い2008

    • Author(s)
      久保田龍二
    • Organizer
      第49回日本神経学会
    • Place of Presentation
      横浜市
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HLA-A24はHAMでは頻度が高いがウイルス量は低い。2008

    • Author(s)
      久保田龍二
    • Organizer
      第49回日本神経学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2008-05-15
    • Data Source
      KAKENHI-PROJECT-19390243
  • [Presentation] HAMとキャリアにおけるHTLV-I特異的CTL機能の比較

    • Author(s)
      久保田龍二、有島志保、松崎敏男、高嶋 博、出雲周二
    • Organizer
      第5回HTLV-I研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-24591271
  • 1.  IZUMO Shuji (30143811)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 53 results
  • 2.  HURUKAWA Yoshitaka (00359978)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 3.  OSAME Mitsuhiro (10041435)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 4.  ARIMURA Kimiyoshi (20159510)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 8 results
  • 5.  UMEHARA Hujio (20271140)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 6.  MORI Kazuyasu (20270655)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  USUKU Koichiro (30281223)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  Arima Naomichi (30175997)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  蓮井 和久 (70198703)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 10.  吉満 誠 (70404530)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  田中 正和 (20454613)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 18 results
  • 12.  OKAMOTO Mika (90336347)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  YAMANO Yoshihisa (80445882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 14.  小迫 知弘 (40398300)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  中尾 久美子 (30217658)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  松浦 英治 (30598800)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 17.  SAITO Mineki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  KURAMITSU Madoka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  TANAKA Hideo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  KUBO Michiaki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  MIURA Kiyonori
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 22.  HASEGAWA Hiroo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 23.  SATO Tomoo
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 24.  高橋 隆
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 25.  松浦 正明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 26.  田中 恵太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 27.  田中 祐吉
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  田中 勇悦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 29.  浜口 功
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 30.  岩永 正子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  内丸 薫
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  渡辺 俊樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 33.  佐々木 大介
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 34.  渡辺 能行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 35.  松尾 恵太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  Firouzi Sanaz
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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