MATSUYAMA Takami 松山隆美

Researcher Number	30145479
Other IDs
External Links
Affiliation (Current)	2020: 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 学外協力研究者
Affiliation (based on the past Project Information) *help	2015: 鹿児島大学, 医用ミニブタ先端医療開発研究センター, 客員教授 2014 – 2015: 鹿児島大学, 医用ミニブタ・先端医療開発研究センター, 客員教授 2013: 鹿児島大学, 医歯学総合研究科, 教授 2011 – 2013: 鹿児島大学, 医歯(薬)学総合研究科, 教授 2010: 鹿児島大学, 医歯学総合研究科, 教授 … More
Review Section/Research Field	Principal Investigator 内科学一般 / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Human pathology / Biomedical engineering/Biological material science / Circulatory organs internal medicine / Digestive surgery / 内科学一般 / Hygiene / Human pathology / Ophthalmology / Orthopaedic surgery
Keywords	Principal Investigator 慢性関節リウマチ / マクロファージ / 滑膜 / 葉酸リセプター / イムノトキシン / VLA / VCAM-1 / Rheumatoid Arthritis / HB-EGF / 関節リウマチ … More Except Principal Investigator T細胞性リンパ腫 / EBV / 鼻型NK / 中国東北地方 / SLE / VLA-4 / LFA-1 / 免疫学 / 鼻NK / 国際共同研究 / 中国 / International co-operative study / CRP / VEGF / 異種移植 / クラウン系ミニブタ / クローンミニブタ / α-1,3-ガラクトース / 転移酵素 / ブタ内在性レトロウイルス(PERV) / HMGB-1 / 制御性T細胞 / α-1,3-ガラクトース転移酵素 / 内在性レトロウイルス(PERV) / gene targeting / 樹状細胞 / α-1,3-ガラクトース転移酸素 / T細胞リンパ腫 / 鼻咽頭癌 / (免疫)組織化学 / 腫瘍共生樹状細胞 / Epstein-Barr virus (EBV) / プログラム細胞死 / 酸化ストレス / 人体病理学 / 鼻型NK/T細胞リンパ腫 / 鼻咽頭扁平上皮癌 / Epstein-Barr virus(EBV) / 活性酸素種(ROS) / inducible nitric oxide synthase (iNOS) / CD204陽性樹状細胞 / 中国(東北地方) / 節外性NK / 上咽頭癌 / 癌幹細胞 / 環境因子 / 自己貪食細胞死 / リンパ腫細胞増殖パターン / 鼻咽頭リンパ腫 / NK / サバイビン / 細胞死 / 鼻リンパ腫 / 小児慢性EBV感染症 / EBER-1 / 鼻腔EBV関連B細胞性リンパ腫 / 動脈硬化 / 葉酸レセプターβ / マクロファージ / 活性化マクロファージ / 分子イメージング / pancreatic cancer / cancer stem cell / CD133 / macrophage / FRb-receptor / tumor microenvironment / miR-30 / FRbeta / microRNA / invasion / migration / FRb receptor / fibrotic stroma / nude mouse / EMT / N-cadherin / miRNA / caerulein誘導慢性膵炎 / FRβマクロファージ / CD68マクロファージ / ヒト化抗FRαβ抗体 / リンパ球 / 血管内皮細胞 / 血管炎 / VLAー4 / LFAー1 / Lymphocytes / HUVEC / Vasculitis / 免疫疾患 / アレルギー疾患 / リュウマチ / 疫学 / 共同研究 / 慢性関節リウマチ / 皮膚免疫疾患 / 職業アレルギー / アレルギー学 / 接着分子 / サイトカイン / 慢性リウマチ / アレルギー皮膚疾患 / 表面抗原 / HLA / 臨床疫学 / 比較研究 / Immunologic disorders / Allergy / RA / epidemiology / Cooperative study / アプトーシス / 背景間質細胞 / 細胞起原 / 先行病変 / 皮膚鼻型NK / 病理標本 / 悪性リンパ腫 / 鼻NK細胞性リンパ腫 / CD203 / CD34 / CD117 / 幹細胞の免疫組織化学 / 分子病理学 / 免疫組織化学 / in-situ hybridization / Epstein Barr virus / 病理疫学 / In-situ hybridization / Epstein-Barr virus / Nasal NK / T-cell lymphoma / Apoptosis / Background stromal cells / Cell origin / Premonitory lesions / Cutaneous nasal type NK / Pathology-specimen / 鼻咽頭悪性腫瘍 / T細胞性りンパ腫 / 臨床病理学的検索 / 組織化学的検索 / 外来性発癌因子 / 幹細胞の組織化学 / 細胞死の組織化学 / 鼻咽頭部の悪性腫瘍 / Apoptosisの免疫組織化学的検索方法 / 組織幹細胞の免疫組織化学的検出 / 超高感度免疫組織化学的染色方法 / 中国の皮膚リンパ腫 / CD30陽性皮膚リンパ球増殖性疾患 / The east-northern China / Nasopharyngeal malignant tumors / Nasal type NK / T-cell lymphomas / Clinicopathological study / Histochemical analysis / External oncogenic factors / ヒアロサイト / 超音波 / 遺伝子導入 / 硝子体手術 / Hyalocvte / Ultrasound / gene transfer / lubricin / 関節リウマチ / sMSFタンパク / ヒアルロン酸 / 蛋白質 / Lubricin / Rheumatoid Arthritis / sMSF protein / Hyaluronic acid Less

Analysis of the interaction between the folate receptor beta expression macrophages and cancer stem cells in pancreatic cancer invasion
- Principal Investigator
  
  TAKAO SONSHIN
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Kagoshima University
Development of the molecular imaging and the therapy of the unstable plaque targeting activated macrophages
- Principal Investigator
  
  MIYATA MASAAKI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Kagoshima University
Therapy targeting folate receptor beta expressing macrophages in chronic inflammationPrincipal Investigator
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kagoshima University
Academic project of oncogenic factors in malignant tumors and the related diseases in northeast China
- Principal Investigator
  
  HASUI Kazuhisa
- Project Period (FY)
  2007 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kagoshima University
A fundamental study on xenotransplantation
- Principal Investigator
  
  TAKAO Sonshin
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  Kagoshima University
Biology of Vitreous Body : Development of new treatment for chorioretinal diseases by controlling vitreous body
- Principal Investigator
  
  SAKAMOTO Taiji
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Kagoshima University
A preclinical study using recombinant anti-folate receptor-beta immunotoxin for the treatment of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  Kagoshima University
A New Function of The Lubricin and It's Role in the Pathogenesis of Arthritis.
- Principal Investigator
  
  YAMAMOTO Takuya
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kagoshima University
Academic research project on oncogenic factors in malignant tumors in the eastnorthern China
- Principal Investigator
  
  HASUI Kazuhisa
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kagoshima University
Academic research project on oncogenic factors in malignant lymphomas in the east-northern China
- Principal Investigator
  
  HASUI Kazuhisa
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Human pathology
- Research Institution
  Kagoshima University
The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kagoshima University
Inhibitory effects of membraneous beparin binding EGF like Factor on the apoptosis.Principal Investigator
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kagoshima University
Mechanisms of the anergy of T cells induced by varient types of soluble VCAM-1Principal Investigator
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kagoshima University
滑膜炎症性マクロファージに多量に発現する分子のcDNAクローニングPrincipal Investigator
- Principal Investigator
  
  松山隆美
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kagoshima University
Japan-China cooperative study on immuno-allergic disorders -Specially on the occurrence and treative measures-
- Principal Investigator
  
  MATSUSHITA Toshio
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Hygiene
- Research Institution
  Kagoshima University
The role of VLA proteins and fibronectin in the activation of synovial cells from rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  MATSUYAMA Takami
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Kagoshima University
  Saitama Medical University
Molecular immunological study on the pathogenesis of vasculitis in SLE
- Principal Investigator
  
  TAKEUCHI Tsutomu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  Saitama Medical School

All 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

[Book] Proceedings of The 10th Japanese-Korean Lymphoreticular Workshop 2009 and Symposiums : Asian Hematopathology (2009.10.28-30, Fukushima View Hotel).(Edited by Abe M, Kang CS.)(The Japanese Lymphoreticular Study Group, Fukushima, Japan.2)2010
- Author(s)
  Hasui K, Wang J, Jia XS, Matsuyama T, Izumo S, Kawano Y, Kanekura T, Eizuru Y, Aozasa K.
- Publisher
  Pathoepidemiology of Epstein-Barr virus (EBV) infection and peculiar necrosis in nasal NK/T-cell lymphomas (NKTCL) in northeast China.
- Data Source
  KAKENHI-PROJECT-19406007
[Book] Pathoepidemiology of Epstein-Barr virus (EBV) infection and peculiar necrosis in nasal NK/T-cell lymphomas (NKTCL) in northeast China. Proceedings of the 10th Japan-Korean Lymphoreticular Workshop2009
- Author(s)
  Hasui K, Wang J, Jia XS, Matsuyama T, Izumo S, Kawano Y, Kanekura T, Eizuru Y, Aozasa K.
- Publisher
  Fukushima View Hotel(in press)
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Production of a High-affinity Monoclonal Antibody Reactive with Folate Receptors Alpha and Beta.2015
- Author(s)
  Nagai T, Furusho Y, Li H, Hasui K, Matsukita S, Sueyoshi K, Yanagi M, Hatae M, Takao S,　Matsuyama　T.
- Journal Title
  
  Monoclon Antib Immunodiagn Immunother.
  
  Volume: 34 Pages: 181-190
- DOI
  10.1089/mab.2014.0072
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25293288
[Journal Article] Depletion of folate receptor β-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis.2014
- Author(s)
  Li H, Nagai T, Hasui K, Matsuyama T.
- Journal Title
  
  Mod Rheumatol.
  
  Volume: - Pages: 816-822
- DOI
  10.3109/14397595.2013.879415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23592134, KAKENHI-PROJECT-25293288
[Journal Article] Depletion of folate receptorβ-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis2014
- Author(s)
  Hua Li, Taku Nagai, Kazuhisa Hasui, Takami Matsuyama
- Journal Title
  
  Modern Rheumatology
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A.2014
- Author(s)
  Samaniego R, Palacios BS, Domiguez-Soto A, Vidal C, Salas A, Matsuyama T, Sanchez-Torres C, de la Torre I, Miranda-Caros ME, Sanchez-Mateos P, Puig-Kruger A.
- Journal Title
  
  J Leukoc Biol.
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Depletion of folate receptor β-expressing macrophages alleviates bleomycin-induced experimental skin fibrosis.2014
- Author(s)
  Li H, Nagai T, Hasui K, Matsuyama T.
- Journal Title
  
  Modern Rheumatology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Macrophage uptake and accumulation of folates is polarization-dependent in vitro and in vivo, and is regulated by activin A2014
- Author(s)
  Rafael Samaniego, Blanca Soler Palacios, Angeles Dominguez-Soto, Carlos Vidal, Azucena Salas, Takami Matsuyama, Carmen Sanchez-Torres, Inmaculada de la Torre, Maria Eugenia Miranda-Carus,Paloma Sanchez-Mateos, and Amaya Puig-Kruger
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A.2014
- Author(s)
  Samaniego R, Palacios BS, Domiguez-Soto A, Vidal C, Salas A, Matsuyama T, Sánchez-Torres C, de la Torre I, Miranda-Carús ME, Sánchez-Mateos P, Puig-Kröger A.
- Journal Title
  
  Journal of Leukocyte Biology
  
  Volume: 95 Pages: 797-808
- DOI
  10.1189/jlb.0613345
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293288
[Journal Article] Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles.2012
- Author(s)
  Tsuneyoshi Y, Tanaka M, Nagai T, Sunahara N, Matsuda T, Sonoda T, Ijiri K, Komiya S, Matsuyama T.
- Journal Title
  
  Scand J Rheumatol.
  
  Volume: ４１（２） Pages: 132-40
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] The prolyl hydroxylase PHD3 identifies proinflammatory macrophages and its expression is regulated by activin A.2012
- Author(s)
  Escribese MM, Sierra-Filardi E, Nieto C, Samaniego R, Sánchez-Torres C, Matsuyama T, Calderon-Gómez E, Vega MA, Salas A, Sánchez-Mateos P, Corbí AL.
- Journal Title
  
  J Immunol.
  
  Volume: １８９ Pages: 1946-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis2012
- Author(s)
  Nagai T, Kyo A, Hasui K, Takao S, Matsuyama T
- Journal Title
  
  Arthritis research & therapy
  
  Volume: 14(3)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages.2012
- Author(s)
  Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: 1
- DOI
  10.1161/jaha.112.003079
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591105, KAKENHI-PROJECT-23592134, KAKENHI-PROJECT-24890178
[Journal Article] Functional folate receptor beta-expressing macrophages in osteoarthritis synovium and their M1/M2 expression profiles2012
- Author(s)
  Tsuneyoshi Y, Tanaka M, Nagai T, Sunahara N, Matsuda T, Sonoda T, Ijiri K, Komiya S, Matsuyama T
- Journal Title
  
  Scand J Rheumatol
  
  Volume: 41(2) Pages: 132-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptorβ―expressing Macrophages2012
- Author(s)
  Furusho Y, Miyata M, Matsuyama T, Nagai T, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C
- Journal Title
  
  Journal of the American Heart Association
  
  Volume: 1(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis.2012
- Author(s)
  Nagai T, Kyo A, Hasui K, Takao S, Matsuyama T.
- Journal Title
  
  Arthritis Res Ther. 2012
  
  Volume: １４
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Novel Therapy for Atherosclerosis Using Recombinant Immunotoxin Against Folate Receptor β-Expressing Macrophages.2012
- Author(s)
  Furusho Y, Miyata M, Matsuyama T, Nagai T, Li H, Akasaki Y, Hamada N, Miyauchi T, Ikeda Y, Shirasawa T, Ide K, Tei C.
- Journal Title
  
  J Am Heart Assoc.
  
  Volume: １（４）
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] The Prolyl Hydroxylase PHD3 Identifies Q :1; 2; 3 Proinflammatory Macrophages and its Expression Is Regulated by Activin A2012
- Author(s)
  Mar´ıa M. Escribese, Elena Sierra-Filardi, Concha Nieto, Rafa Samaniego,†Carmen Sa´nchez-Torres,‡Takami Matsuyama, Elisabeth Calderon-Go´mez, Miguel A. Vega, Azucena Salas,Paloma Sa´nchez-Mateos, and Angel L. Corbı
- Journal Title
  
  J Immunol
  
  Volume: 189(4) Pages: 1946-54
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23591441
[Journal Article] Effect of an immunotoxin to folate receptor beta on bleomycin-induced experimental pulmonary fibrosis.2010
- Author(s)
  Nagai T, Tanaka M, Hasui K, Shirahama H, Kitajima S, Yonezawa S, Xu B, Matsuyama T.
- Journal Title
  
  Clin Exp Immunol.
  
  Volume: 161(2) Pages: 348-356
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Possible role for external environmental stimuli in nasopharyngeal NK/T-cell lymphomas in the northeast of China with EBV infection-related autophagic cell death.2009
- Author(s)
  Wang J, Hasui K, Jia X, Matsuyama T, Eizuru Y.
- Journal Title
  
  J Clin Exp Hematop. 49(2)
  
  Pages: 97-108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Possible role for external environmental stimuli in nasopharyngeal NK/T-cell lymphomas in the northeast of China with EBV infection-related autophagic cell death : a pathoepidemiological analysis2009
- Author(s)
  Wang J, Hasui K, Jia X, Matsuyama T, Eizuru Y
- Journal Title
  
  J.Clin.Exp.Hematopath. 49(2)
  
  Pages: 97-108
- NAID
  10026387672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Possible role for external environmental stimuli in nasopharyn geal NK/T-cell lymphomas in the northeast of China with EBV in fection-related autophagic cell death ; : A pathoepidemiological analysis.2009
- Author(s)
  Jia Wang, Kazuhisa Hasui, Xinshan Jia, Takami Matsuyama, Yoshito Eizuru
- Journal Title
  
  Journal of Clinical and Experimental Hemato pathology 49(In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Possible role for external environmental stimuli in nasopharyngeal NK/T-cell lymphomas in the northeast of China with EBV infection-related autophagic cell death : a pathoepidemiological analysis2009
- Author(s)
  Wang J, Hasui K, Jia XS, Matsuyama T, Eizuru Y.
- Journal Title
  
  J Clin Exp Hematopath 49(2)
  
  Pages: 97-108
- NAID
  10026387672
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor beta2009
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Xu B, Michie SA, Hasui K, Hirano H, Arita K, Matsuyama T.
- Journal Title
  
  Immunother. 58(10)
  
  Pages: 1577-86
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Association of High Proliferation in Adult T-cell Leukemia Cells with Apoptosis, and Expression of p53 Protein in Acute Type ATL.2008
- Author(s)
  Jia Wang, Kazuhisa Hasui, Atae Utsunomiya, xinshan Jia, Takami Matsuyama, Fusayoshi Murata.
- Journal Title
  
  Journal of Clinical and Experimental Hemato pathology 48
  
  Pages: 1-10
- NAID
  10021246669
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T.
- Journal Title
  
  Arthritis ＆ Rheumatism 54(10)
  
  Pages: 3126-3134
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17591051
[Journal Article] Ii vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T
- Journal Title
  
  Arthritis ＆ Rheumatism 54(10)
  
  Pages: 3126-34
- Data Source
  KAKENHI-PROJECT-17591051
[Journal Article] In vitro and in vivo efficacy of a recombinant immunotoxin against folate receptor beta on the activation and proliferation of rheumatoid arthritis synovial cells.2006
- Author(s)
  Nagai T, Tanaka M, Tsuneyoshi Y, Matsushita K, Sunahara N, Matsuda T, Yoshida H, Komiya S, Onda M, Matsuyama T
- Journal Title
  
  Arthritis ＆ Rheumatism. 54(10)
  
  Pages: 3126-3134
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17591051
[Journal Article] Phenotypic and functional profiles of CRIg (Z39Ig)-expressing macrophages in the large intestine.
- Author(s)
  Tanaka M, Nagai T, Usami M, Hasui K, Takao S, Matsuyama T.
- Journal Title
  
  Innate Immunity
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Enhanced autophagy and reduced expression of Cathepsin D could be related to autophagic cell death in Epstein-Barr virus-associated nasal natural killer/T-cell lymphomas.
- Author(s)
  Hasui K, Wang J, Jia XS, Tanaka M, Nagai T, Matsuyama T, Eizuru Y.
- Journal Title
  
  ActaHistochem Cytochem. 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Journal Article] Enhanced autophagy and reduced expression of Cathepsin D could be related to autophagic cell death in Epstein-Barr virus-associated nasal natural killer/T-cell lymphomas : an immunohistochemical analysis of Beclin-1, LC3, mitochondria (AE-1) and Cathepsin D in nasopharyngeal lymphomas.
- Author(s)
  Hasui K, Wang J, Jia XS, Tanaka M, Nagai T, Matsuyama T, Eizuru Y.
- Journal Title
  
  Acta Histochemica et Cytochemica
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19406007
[Patent] Therapeutic agent for arteriosclerosis or arteriosclerotic diseae, and diagnositic agent for arteriosclerosis or arteriosclerosic disease2013
- Inventor(s)
  宮田昌明、松山隆美、永井　拓
- Industrial Property Rights Holder
  宮田昌明、松山隆美、永井　拓
- Industrial Property Rights Type
  特許
- Filing Date
  2013-05-09
- Overseas
- Data Source
  KAKENHI-PROJECT-23591105
[Patent] 強皮症治療剤2013
- Inventor(s)
  松山隆美、李花、永井拓
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-054090
- Filing Date
  2013-03-15
- Overseas
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 軟骨又は骨の破壊の診断薬2012
- Inventor(s)
  松山隆美、永井拓
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-241968
- Filing Date
  2012-11-01
- Overseas
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] リコンビナント抗葉酸受容体-βイムノトキシンによる強皮症の治療2012
- Inventor(s)
  李花、松山隆美、永井拓、蓮井和久
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-281525
- Filing Date
  2012-12-25
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 葉酸リセプターα及びβを認識する抗体2012
- Inventor(s)
  松山隆美、永井拓、蓮井和久、高尾尊身
- Industrial Property Rights Holder
  鹿児島大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-281525
- Filing Date
  2012-12-25
- Overseas
- Data Source
  KAKENHI-PROJECT-23591441
[Patent] 動脈硬化又は動脈硬化性疾患の治療剤、及び動脈硬化又は動脈硬化性疾患の診断薬2011
- Inventor(s)
  宮田昌明、古庄優子、鄭忠和、永井拓、松山隆美
- Industrial Property Rights Holder
  宮田昌明、古庄優子、鄭忠和、永井拓、松山隆美、鹿児島大学
- Industrial Property Rights Type
  特許
- Filing Date
  2011-07-12
- Data Source
  KAKENHI-PROJECT-23591105
[Patent] 葉酸レセプターβを標的とした選択的新規動脈硬化治療法2011
- Inventor(s)
  鄭　忠和、宮田昌明、古庄優子、松山隆美、永井　拓
- Industrial Property Rights Holder
  鄭　忠和、宮田昌明、古庄優子、松山隆美、永井　拓
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23591105
[Patent] 動脈硬化又は動脈硬化性疾患の治療剤、及び動脈硬化又は動脈硬化性疾患の診断薬2011
- Inventor(s)
  宮田昌明、古庄優子、鄭忠和、永井拓、松山隆美
- Industrial Property Rights Holder
  宮田昌明、古庄優子、鄭忠和、永井拓、松山隆美、鹿児島大学
- Industrial Property Rights Type
  特許
- Filing Date
  2011-11-08
- Overseas
- Data Source
  KAKENHI-PROJECT-23591105
[Patent] 免疫組織染色を用いる細胞の解析方法2009
- Inventor(s)
  蓮井和久, 王嘉, 松山隆美, 榮鶴義人
- Industrial Property Rights Holder
  蓮井和久
- Industrial Property Number
  2009-001595
- Filing Date
  2009-01-07
- Data Source
  KAKENHI-PROJECT-19406007
[Patent] 免疫組織染色を用いる細胞の解析方法2009
- Inventor(s)
  蓮井和久、王嘉、松山隆美、榮鶴義人
- Industrial Property Rights Holder
  蓮井和久
- Industrial Property Number
  2009-001595
- Filing Date
  2009-01-07
- Data Source
  KAKENHI-PROJECT-19406007
[Patent] 免疫組織染色を用いる細胞の解析方法2009
- Inventor(s)
  蓮井和久, 王嘉, 松山隆美, 柴鶴義人
- Industrial Property Rights Holder
  蓮井和久
- Industrial Property Number
  2009-001595
- Filing Date
  2009-01-07
- Data Source
  KAKENHI-PROJECT-19406007
[Patent] 葉酸リセプターベータ(FRβ)に対する単クローン抗体を含有する治療薬2005
- Inventor(s)
  松山隆美他4名
- Industrial Property Rights Holder
  松山隆美
- Filing Date
  2005-04-25
- Data Source
  KAKENHI-PROJECT-17100007
[Presentation] Slug contributes to gemcitabine resistance through epithelial-mesenchymal transition in CD133+ pancreatic cancer cells.2015
- Author(s)
  Koichiro Tsukasa, Qiang Ding, Makoto Yoshimitsu, Yumi Miyazaki, Shyuichiro Matsubara, Shoko Ueno, Toru Obara , Takami Matsuyama, Sonshin Takao
- Organizer
  第33回ヒト細胞学会学術集会
- Place of Presentation
  宮崎市
- Year and Date
  2015-08-23
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] The detection of a soluble folate receptor beta in rheumatoid arthritis under anti-TNF therapy2013
- Author(s)
  永井拓、大坪秀雄、李花、松田剛正、松山隆美
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  横浜
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] 葉酸リセプターβ発現マクロファージを標的とした強皮症モデルの治療に関する研究2013
- Author(s)
  李花、永井拓、松山隆美
- Organizer
  第57回日本リウマチ学会
- Place of Presentation
  横浜
- Year and Date
  2013-04-19
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] Targeting FR-b-expressing macrophages in inflammatory diseases2012
- Author(s)
  松山隆美
- Organizer
  第4回葉酸リセプターとトランスポーターシンポジウム
- Place of Presentation
  メキシコ
- Year and Date
  2012-10-09
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] Immunotherapy of antigen-induced rat arthritis with an anti-folate receptor beta Recombinant immunotoxin2012
- Author(s)
  Taku Nagai, Nobuhiko Sunahara, Takemasa Matsuda, Takami Matsuyama
- Organizer
  第56回日本リウマチ学会
- Place of Presentation
  京都
- Year and Date
  2012-04-27
- Data Source
  KAKENHI-PROJECT-23591441
[Presentation] 鼻咽頭リンパ腫病変の点突然変異を生じる可能性のある酸化修飾DNA(8-OHdGとTG)の免疫組織化学的検討2010
- Author(s)
  蓮井和久、賈心善、青笹克之、竹内亨、出雲周二、河野嘉文、金蔵拓郎、榮鶴義人、松山隆美
- Organizer
  第51回日本組織細胞化学会総会・学術集会 2010年9月4(土)-5日(日)
- Place of Presentation
  東京(秋葉原コンベンションホール)
- Year and Date
  2010-09-04
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] A symbiotic growth of nasal NK/T-cell lymphoma cells with CD204-positive macrophages would defense themselves from endogenous reactive oxygen spices-induced cell necrosis2010
- Author(s)
  Hasui K, Jia XS, Takeya M, Kanekura T, Kawano Y, Izumo S, Eizuru Y, Matsuyama T.
- Organizer
  第18回マクロファージ分子生物学国際シンポジウム平成22年5月20-21日
- Place of Presentation
  熊本(くまもと県民交流館パレア)
- Year and Date
  2010-05-20
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] Immunohistochemical analysis of oxidative modified DNA (8-OHdG) in Chinese nasopharyngeal lymphomas.2010
- Author(s)
  Hasui K, Jia XS, Aozasa K, Eizuru Y, Matsuyama T, Sato E.
- Organizer
  第6回国際分子病理学シンポジウム平成22年8月20-21日
- Place of Presentation
  中国青海省西寧市(軍交大廈)
- Year and Date
  2010-08-20
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] 鼻NK/T細胞リンパ腫細胞とCD204陽性マクロファージとの共生は活性酸素種による細胞死に抵抗性である2010
- Author(s)
  蓮井和久、賈心善、竹屋元裕、田代幸恵、金蔵拓郎、河野嘉文、出雲周二、榮鶴義人、松山隆美、佐藤榮一
- Organizer
  第20回日本樹状細胞研究会平成22年6月18～19日
- Place of Presentation
  新潟(朱鷺メッセ:新潟コンベンションセンター)
- Year and Date
  2010-06-18
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] 鼻咽頭リンパ腫における自己貪食の免疫組織化学的検索2009
- Author(s)
  蓮井和久, 王嘉, 賈心善, 松山隆美, 榮鶴義人, 佐藤榮一
- Organizer
  日本顕微鏡学会第62回学術講演会
- Place of Presentation
  仙台国際センター
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] EBV感染下の自己貪食・自己貪食細胞死は鼻咽頭リンパ腫の特異な壊死を特徴づけている(免疫組織化学的自己貪食機能解析の試み)2009
- Author(s)
  蓮井和久, 王嘉, 賈心善, 松山隆美, 榮鶴義人
- Organizer
  第50回日本組織細胞化学会総会・学術集会
- Place of Presentation
  ピアザ淡海滋賀県民交流センター
- Year and Date
  2009-09-28
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] Pathoepidemiology of Epsten-Barr virus(EBV)infection and peculiar necrosis in nasal NK/T-cell lymphomas(NKTCL)in northeast China2009
- Author(s)
  Hasui K, Wang J, Jia XS, Matsuyama T, Izumo S, Kawano Y, Kanekura T, Eizuru Y, Aozasa K
- Organizer
  第10回日韓リンパ網内系ワークショップ
- Place of Presentation
  福島ビューホテル
- Year and Date
  2009-10-29
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] Nasal NK/T-cell lymphoma in Northeast China2009
- Author(s)
  蓮井和久, 王嘉, 賈心善, 松山隆美, 榮鶴義人
- Organizer
  第3回日中病理学シンポジウム
- Place of Presentation
  中国済南市山東大学医学部
- Year and Date
  2009-08-03
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] EBウイルス関連頭頚部悪性腫瘍の多発傾向を示す中国東北地方の鼻悪性リンパ腫の発生状況のウイルス・病理疫学的研究2008
- Author(s)
  蓮井和久, 王嘉, 賈心善, 佐藤榮一, 松山隆美, 榮鶴義人
- Organizer
  第12回鹿児島ヘルペスウイルス研究会
- Place of Presentation
  鹿児島東急ホテル(鹿児島市)
- Year and Date
  2008-07-08
- Data Source
  KAKENHI-PROJECT-19406007
[Presentation] Asian Symposium:Nasal NK/T-cell lymphomas in the northeast region of China2007
- Author(s)
  Hasui K, Jia XS, Yonezawa S, Izumo S, Kanzaki T, Matsuyama T, Aozasa K
- Organizer
  第96回日本病理学会総会
- Place of Presentation
  大阪(国際会議場)
- Year and Date
  2007-03-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16406006
[Presentation] Asian Symposium : Nasal NK/T-cell lymphomas in the northeast region of China2007
- Author(s)
  Hasui, K., Jia, XS., Yonezawa, S., Izumo, S., Kanzaki, T., Matsuyama, T., Aozasa, K
- Organizer
  The 96th Annual Meeting of the Japanese Society of Pathology
- Place of Presentation
  Osaka International Convention Center
- Year and Date
  2007-03-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16406006
[Presentation] Efficacy of an antibody reactive with human folate receptors a and b in targeting cancer cells and TAMs
- Author(s)
  Nagai T, Hasui K, Matsuyama T, Takao S, Hatae M, Sueyoshi K, Matsukida S
- Organizer
  第７２回日本癌学会学術総会
- Place of Presentation
  横浜市　パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-25293288
[Presentation] The roles of novel tumor-associated macrophages (TAMs) in invasion and metastasis of pancreatic cancer
- Author(s)
  Sonshin Takao, Qiang Ding, Taku Nagai, Hiroshi Kurahara, Makoto Yoshimitsu, Taisaku Kuwahata, Yumi Miyazaki, Ryoko Imakiire, Shoko Ueno, Toru Obara, Takami Matsuyama
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington DC, USA
- Data Source
  KAKENHI-PROJECT-25293288

1. KANZAKI Tamotu (80118801)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
2. IZUMO Syuji (30143811)

# of Collaborated Projects: 3 results

# of Collaborated Products: 8 results
3. YONEZAWA Sugury (10175002)

# of Collaborated Projects: 3 results

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# of Collaborated Projects: 3 results

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# of Collaborated Projects: 3 results

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8. EIZURU Yoshito (00041351)

# of Collaborated Projects: 2 results

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9. KANEKURA Takuro (70177509)

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10. KOIDE Jun (70178193)

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13. 佐藤榮一 (60004579)

# of Collaborated Projects: 2 results

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15. ATO Masahiro (30287099)

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16. MARUYAMA Ikuro (20082282)

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18. FUJIYOSHI Toshinobu (50173480)

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19. KAWANO Yoshifumi (20260680)

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# of Collaborated Products: 6 results
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22. MIYATA MASAAKI (00347113)

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23. FURUSHO Yuko (00632514)

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24. DING QIANG (80457647)

# of Collaborated Projects: 1 results

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25. YOSHIMITSU MAKOTO (70404530)

# of Collaborated Projects: 1 results

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26. AMANO Kohichi (00175928)

# of Collaborated Projects: 1 results

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27. ABE Tohru (60051207)

# of Collaborated Projects: 1 results

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28. MATSUSHITA Toshio (10022790)

# of Collaborated Projects: 1 results

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29. AOYAMA Kohji (70117472)

# of Collaborated Projects: 1 results

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30. MATSUSHITA Noriko (00244228)

# of Collaborated Projects: 1 results

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31. NAKAMURA Motoyuki (30343362)

# of Collaborated Projects: 1 results

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32. SAKAMOTO Taiji (10235179)

# of Collaborated Projects: 1 results

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33. AOYAGI Takao (40277132)

# of Collaborated Projects: 1 results

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34. SUEISHI Katsuo (70108710)

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35. YAMAMOTO Takuya (40381157)

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36. KOMIYA Setsuro (30178371)

# of Collaborated Projects: 1 results

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37. 三好逸男 (80253871)

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38. 胥宝会 (00264408)

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39. 大山勝 (70024677)

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40. 福田勝則 (90156779)

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41. 中川正法 (50198040)

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42. 屋敷伸治 (40182315)

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43. 佐藤克明 (40301147)

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44. 田中将志 (60381167)

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45. 松下格司 (00363630)

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46. JIA Xinshan

# of Collaborated Projects: 1 results

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48. OKUMURA Teruhisa

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49. 丁桂英

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50. 宋芳吉

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51. SOONG Fangji

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# of Collaborated Projects: 1 results

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53. 趙麗娟

# of Collaborated Projects: 1 results

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56. 季文越

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57. 張久松

# of Collaborated Projects: 1 results

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58. AKASAKI Yuichi

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MATSUYAMA Takami 松山 隆美

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Therapy targeting folate receptor beta expressing macrophages in chronic inflammationPrincipal Investigator

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A preclinical study using recombinant anti-folate receptor-beta immunotoxin for the treatment of rheumatoid arthritisPrincipal Investigator

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The diagnostic and pathological significance of soluble CD163 in rheumatoid arthritisPrincipal Investigator

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Inhibitory effects of membraneous beparin binding EGF like Factor on the apoptosis.Principal Investigator

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Mechanisms of the anergy of T cells induced by varient types of soluble VCAM-1Principal Investigator

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滑膜炎症性マクロファージに多量に発現する分子のcDNAクローニングPrincipal Investigator

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MATSUYAMA Takami 松山隆美