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TAKEUCHI Tsutomu  竹内 勤

ORCIDConnect your ORCID iD *help
Researcher Number 50179610
External Links
Affiliation (based on the past Project Information) *help 2022: 慶應義塾大学, 医学部(信濃町), 特任教授
2021: 慶應義塾大学, 医学部(信濃町), 名誉教授
2017 – 2020: 慶應義塾大学, 医学部(信濃町), 教授
2009 – 2016: Keio University, 医学部, 教授
1997 – 2009: SAITAMA MEDICAL SCHOOL,SCHOOL OF MEDICINE,PROFESSOR, 医学部, 教授 … More
2002: 埼玉医科大学, 総合医療センター, 教授
1992 – 1997: Saitama Medical Center 2nd Department of Medicine Associate Professor, 医学部, 助教授
1991: 埼玉医科大学, 医学部, 教授
1991: 埼玉医科大学, 医学部, 講師
1989: Saitama Medical Center 2nd Dep. Int. Med. Assistant Professor, 総合医療センター 第2内科, 講師
1989: 埼玉医科大学, 総合医療センター・第2内科, 講師
1988: 助手 Less
Review Section/Research Field
Principal Investigator
内科学一般 / 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related
Except Principal Investigator
内科学一般 / 膠原病・アレルギー・感染症内科学 / Collagenous pathology/Allergology / Basic Section 54020:Connective tissue disease and allergy-related
Keywords
Principal Investigator
SLE / autoimmunity / 自己免疫 / インテグリン / シグナル伝達 / VLA-4 / LFA-1 / CD103 / 関節リウマチ / Integrins … More / 上皮障害 / カドヘリン / FAM20A / 血管内皮細胞 / 血管炎 / Vasculitis / Signal transduction / チロシンリン酸化 / pp125FAK / epithelial cells / adhesion / apoptosis / シェーグレン症候群 / BAFF / TCRζ chain / 自己抗体 / CDIO3 / DNAマイクロアレイ / 遺伝子発現 / 網羅的遺伝子解析 / 病態形成 / mRNA / 発現異常 / 14-3-3zeta / 末梢血 / 機能解析 / JMJD1A / PTPN1 / キナーゼ / 分泌型キナーゼ / 膠原病・アレルギー内科学 / リウマチ内科学 / リンパ球 / VLAー4 / LFAー1 / Lymphocytes / HUVEC / フィブロネクチン / 接着分子 / Fibronectin / Endothelial cells / p125FAK / Tyrosine phosphorylation / E-cadherins / E-カドヘリン / 組織障害 / アポトーシス / シェ-グレン症候群 / E-cadherin / TCRζ鎖 / T細胞リセプター / signaal transduction / T cell receptor / lupus / CD3 zeta chain / tyrosine phosphorylation / T lymphocytes / 3' untranslated region / splicing / 3'untranslated region / autoantibody / splicing variants / microarray / epithelial injuries / adherin / integrin / B細胞 / 抗セントロメア抗体 / 自己抗原 / 全身性強皮症 / レパトア解析 / 自己免疫疾患 / 抗原特異性 / シングルセル解析 / 抗シトルリン化タンパク質抗体 / 抗翻訳後修飾蛋白抗体 / 肺胞洗浄液 / 間質性肺炎 / リウマチ因子 / 寛解、分子病態、網羅的解析 / 診断前継時コホート / 残存分子シグネチャー … More
Except Principal Investigator
signal transduction / alternative splicing / 全身性エリテマトーデス / 慢性関節リウマチ / mRNA 3'UTR / T細胞 / 単球 / シグナル伝達 / 関節リウマチ / rheumatoid arthritis / VLA / VCAM-1 / TCRζ鎖 / MA5.8 / mRNA3'UTR / Systemic lupus erythematosus / EXTL2 / syndecan / 成人発症スティル病 / アンケート / データベース / 発熱 / 関節炎 / 制御性T細胞 / FOXP3 / アイソフォーム免疫寛容 / アイソフォーム / 免疫寛容 / 膠原病学 / サイトカイン / シェーグレン症候群 / BAFF / 細胞シグナル伝達 / IL-6 / JAK3 / 阻害剤 / リン酸化 / BAFF受容体 / 滑膜組織 / 臨床研究 / 低侵襲検査法 / 滑膜生検 / 低侵襲検査 / 関節エコー / 滑膜細胞 / 多核巨細胞 / 破骨活性 / 抗DR抗体 / CD44抗原 / 線維芽様細胞 / 血小板由来増殖因子 / CD3分子 / 燐酸化 / T cell phosphorylation / PDGF / zata chain / CD44 antigen / フィブロネクチン / 滑膜 / フイブロネクチン / 滑膜細胞フィブロネクチン / 形態変化 / チロシンリン酸化 / 活性化 / Rheumatoid Arthritis / Fibronectin / Synovium / 紫外線 / JNK-1 / SLE / リンパ球 / アポトーシス / 光線過敏症 / Ultraviolet / c-Jun N-terminal kinase-1 (JNK-1) / systemic lupus erythematosus (SLE) / lymphocytes / apoptosis / In vitro translation / dimerization / 半定量PCR法 / TCRζ / Syndecan / シンデカン / signla transduction / ヘパラン硫酸 / cDNA microarray / syndecan-1 / exon deletion / TCR ζ / リウマトイド因子 / 肺炎球菌 / 抗イデイオタイプ抗体 / Fc結合蛋白 / 関節症状 / プロテインA / 微生物 / rheumatoid factor / bacterial infection / anti-idiotypic antibody / MS4A4A / 末梢血 / ノックアウトマウス / フローサイトメトリー Less
  • Research Projects

    (23 results)
  • Research Products

    (113 results)
  • Co-Researchers

    (28 People)
  •  Molecular signatures in pre-RA patients by multi-omics analysisPrincipal Investigator

    • Principal Investigator
      竹内 勤
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Keio University
  •  Function and clinical application of MS4A4A involved in pathology of rheumatoid arthritis

    • Principal Investigator
      Yamaoka Kunihiro
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54020:Connective tissue disease and allergy-related
    • Research Institution
      Kitasato University
  •  Multiomics analysis of auto reactive immune cells in the inflammatory sites in autoimmune diseases.Principal Investigator

    • Principal Investigator
      Takeuchi Tsutomu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Keio University
  •  Investigation of regulatory mechanism of secretary protein kinase and its application for treatment of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      Takeuchi Tsutomu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Keio University
  •  Clinical studies on the development of new minimum invasive diagnostic test for rheumatoid arthritis

    • Principal Investigator
      Suzuki Katsuya
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      Keio University
  •  Identification and characterization of pathogenesis related molecules in early rheumatoid arthritis by DNA microarrayPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Keio University
  •  Search for BAFF signaling inhibitors as novel drugs for the treatment of Sjogren's syndrome.

    • Principal Investigator
      YOSHIMOTO Keiko
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Keio University
  •  Analysis on signal transduction pathway through CD103 moleculePrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Saitama Medical University
  •  FOXP3 isoform expression in the regulatory T cells in systemic lupus erythematosus patients and its role in the mechanism of the immue suppression

    • Principal Investigator
      SUZUKI Katsuya
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Saitama Medical University
  •  Molecular mechanism and its regulation of heterophilic adhesion between α E 3 7 (CD103) and E-cadherin in autoimmune epithelial injuryPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Saitama Medical University
  •  Decreased expression of TCRζ and signal transduction due to the aberrantexpression of the TCR mRNA in SLE patient T cells

    • Principal Investigator
      TSUZAKA Kensei
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      Saitama Medical University
  •  成人発症スティル病の診断・治療・予後に関する集学的研究

    • Principal Investigator
      江口 勝美
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Nagasaki University
  •  Molecular mechanism and possible therapeutic target of BAFF upregulation in SLEPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  Analysis of the aberrant TCRζ mRNA 3'UTR in SLE patient T cells

    • Principal Investigator
      TSUZAKA Kensei
    • Project Period (FY)
      2000 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  全身性エリテマトーデス患者T細胞に発現されるTCRζ鎖の異常に関する研究Principal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  Role of alphaEbeta7 on tissue destruction of autoimmune diseasesPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  PATHOGENETIC SIGNIFICANCE OF PROTEIN KINASE JNK-1 INDUCED BY ULTRAVIOLET IN PERIPHERAL BLOOD LYMPHOCYTES FROM SLE PATIENTS

    • Principal Investigator
      AMANO Koichi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      SAITAMA MEDICAL SCHOOL
  •  Study on signal transduction pathway via integrins in autoimmune T cellsPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  Structure of upregulated VLA-4 antigen expressed on PBL from SLEPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  The role of VLA proteins and fibronectin in the activation of synovial cells from rheumatoid arthritis.

    • Principal Investigator
      MATSUYAMA Takami
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Kagoshima University
      Saitama Medical University
  •  Studies on the pathogenesis of rheumatoid arthritis

    • Principal Investigator
      ABE Tohru
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical Center, Saitama Medical School
  •  Molecular immunological study on the pathogenesis of vasculitis in SLEPrincipal Investigator

    • Principal Investigator
      TAKEUCHI Tsutomu
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical School
  •  Studies on the mechanism of rheumatoid factor production

    • Principal Investigator
      ABE Tohru
    • Project Period (FY)
      1988 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      Saitama Medical Center, Saitama Medical School

All 2021 2020 2019 2018 2016 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Patent

  • [Journal Article] Distinct Expression of Coinhibitory Molecules on Alveolar T Cells in Patients With Rheumatoid Arthritis-Associated and Idiopathic Inflammatory Myopathy-Associated Interstitial Lung Disease2021

    • Author(s)
      Nakazawa Maho、Suzuki Katsuya、Takeshita Masaru、Inamo Jun、Kamata Hirofumi、Ishii Makoto、Oyamada Yoshitaka、Oshima Hisaji、Takeuchi Tsutomu
    • Journal Title

      Arthritis & Rheumatology

      Volume: 73 Pages: 576-586

    • DOI

      10.1002/art.41554

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17430, KAKENHI-PROJECT-20H03720
  • [Journal Article] Antigen-driven autoantibody production in lungs of interstitial lung disease with autoimmune disease2021

    • Author(s)
      Takeshita Masaru、Suzuki Katsuya、Nakazawa Maho、Kamata Hirofumi、Ishii Makoto、Oyamada Yoshitaka、Oshima Hisaji、Takeuchi Tsutomu
    • Journal Title

      Journal of Autoimmunity

      Volume: 121 Pages: 102661-102661

    • DOI

      10.1016/j.jaut.2021.102661

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K17430, KAKENHI-PROJECT-20H03720
  • [Journal Article] Antigen-driven selection of antibodies against SSA, SSB and the centromere 'complex', including a novel antigen, MIS12 complex, in human salivary glands.2020

    • Author(s)
      Takeshita Masaru、Suzuki Katsuya、Kaneda Yukari、Yamane Humitsugu、Ikeura Kazuhiro、Sato Hidekazu、Kato Shin、Tsunoda Kazuyuki、Arase Hisashi、Takeuchi Tsutomu
    • Journal Title

      Ann. Rheum. Dis.

      Volume: 79 Pages: 150-158

    • DOI

      10.1136/annrheumdis-2019-215862

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K11853, KAKENHI-PROJECT-18K19450, KAKENHI-PUBLICLY-19H04808, KAKENHI-PROJECT-18H05279, KAKENHI-PROJECT-17H04216
  • [Journal Article] Clinical and immunological features of anti-centromere antibody-positive sjogren’s syndrome.2018

    • Author(s)
      Tsukamoto M, Suzuki K, and Takeuchi T
    • Journal Title

      Rheumatol Ther,

      Volume: 5 Pages: 499-505

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04216
  • [Journal Article] Initial presenting determines clinical entity in patients with anti-centromere antibody positivity.2018

    • Author(s)
      Tsukamoto M, Suzuki K, and Takeuchi T.
    • Journal Title

      Int J Rheum Dis

      Volume: ー

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04216
  • [Journal Article] Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study2016

    • Author(s)
      Nakamura S, Suzuki K, Iijima H, Hata Y, Lim CR, Ishizawa Y, Kameda H, Amano K, Matsubara K, Matoba R, Takeuchi T
    • Journal Title

      Arthritis Research & Therapy

      Volume: 18 Pages: 159-159

    • DOI

      10.1186/s13075-016-1052-8

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09535, KAKENHI-PROJECT-26293233
  • [Journal Article] CD247 variants and single nucleotide polymorphisms observed in systemic lupus erythematosus patients.2013

    • Author(s)
      Takeuchi Takeuchi
    • Journal Title

      Rheumatology(Oxford)

      Volume: Mar 22. [Epub ahead of print]

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] 特集自己免疫疾患の最近の話題と展望マイクロアレイを用いた自己免疫疾患の解析2013

    • Author(s)
      倉沢隆彦, 鈴木勝也, 竹内勤, 他
    • Journal Title

      Pharma Medica

      Volume: vol. 31 No. 1 Pages: 23-26

    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Effectiveness and safety of adalimumab in Japanese patients with rheumatoid arthritis : retrospective analyses of data collected during the first year of adalimumab treatment in routine clinical practice (HARMONY study)2012

    • Author(s)
      Takeuchi T, Tanaka Y, Kaneko Y, Kameda H, Amano K, Yamanaka H., et.al
    • Journal Title

      Mod Rheumatol

      Volume: 6,Sep(Online) Pages: 327-38

    • DOI

      10.1007/s10165-011-0516-6

    • NAID

      10030782043

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259, KAKENHI-PROJECT-23791120
  • [Journal Article] CD3 ζ defects in systemic lupus erythematosus.Ann Rheum Dis.2012

    • Author(s)
      Takeuchi T
    • Journal Title

      Ann Rheum Dis

      Volume: 71

    • DOI

      10.1136/annrheumdis-2011-200641

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21591268, KAKENHI-PROJECT-22591084
  • [Journal Article] CD3 Zeta Defects in Systemic Lupus Erythematosus.2012

    • Author(s)
      Takeuchi Takeuchi
    • Journal Title

      Ann Rheum Dis

      Volume: Apr;71 Suppl 2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Baseline tumor necrosis factor alpha levels predict the necessity for dose escalation of infliximab therapy in patients with rheumatoid arthritis2011

    • Author(s)
      Takeuchi T, Miyasaka N, Tatsuki Y, Yano T, Yoshinari T, Abe T, Koike T
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 1208-1215

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Efficacy of tocilizumab for rheumatoid arthritis patients in daily practice in Japan-message from REACTION study2011

    • Author(s)
      Yamanaka H, Tanaka Y, Inoue E, Hoshi D, Momohara S, Hanami K, Yunoue N, Saito K, Amano K, Kameda H, Takeuchi T
    • Journal Title

      Modern Rheum

      Volume: 21 Pages: 122-133

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Clinical, radiographic, and functional effectiveness of tocilizumab for rheumatoid arthritis patients-REACTION-52 weeks study2011

    • Author(s)
      Takeuchi T, Tanaka Y, Amano K, Hoshi D, Nawata M, Nagasawa H, Satoh E, Saitao K, Kaneko Y, Fukuyo S, Kurasawa T, Hanami K, Kameda H, Yamanaka H
    • Journal Title

      Rheumatology

      Volume: 50 Pages: 1908-1915

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Decreased mRNA expression of two Foxp3 isoforms in peripheral blood mononuclear cells from patients with rheumatoid arthritis and systemic lupus erythematosus2011

    • Author(s)
      Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
    • Journal Title

      Int J Immunopathol and Pharmacology

      Volume: 24 Pages: 7-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Sensitivity and Specificity of 2010 Rheumatoid Arthritis Classification Criteria2011

    • Author(s)
      Kaneko Y, Kuwana M, Kameda H, Takeuchi T., et al
    • Journal Title

      Rheumatology

      Volume: 50 Pages: 1268-1274

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Humanized anti-interieukin 6 receptor antibody (tocilizumab) monotherapy is more effective in slowing radiographic progression in patients with rheumatoid arthritis at high baseline risk for structural damage evaluated with levels of biomakers, radiography, and BMI : data from the SAMURAI study2011

    • Author(s)
      Hashimoto J, Garnero P, van der Heijde, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T., et al
    • Journal Title

      Modern Rheum

      Volume: 21 Pages: 10-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Continuation of Methotrexate resulted in better clinical and radiographic outcomes than discontinuation upon starting etanercept in patients with Rheumatoid Arthritis : 52-Week results from the JESMR Study2011

    • Author(s)
      Kameda H, Tanaka Y, Yamanaka H, Takeuchi T., et.al
    • Journal Title

      J Rheum

      Volume: 38 Pages: 1585-1592

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Postmarketing surveillance of safety and effectiveness of etanercept in Japanese patients with Rheumatoid Arthritis2011

    • Author(s)
      Koike T, Harigai M, Takeuchi T, Tanaka Y, Yamanaka H, Suzukawa M., et.al
    • Journal Title

      Mod Rheum

      Volume: 21 Pages: 343-351

    • NAID

      10029512752

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Fc gamma receptor IIIb polymorphism and usage of glucocorticoids at baseline are associated with infusion reactions to infliximab in patients with rheumatoid arthritis2011

    • Author(s)
      Okuyama A, Nagasawa H, Suzuki K, Kameda H, Kondo H, Amano K, Takeuchi T
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 299-304

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Concise report : Postmarketing surveillance of tocilizumab for rheumatoid arthritis in Japan : interim analysis of 3881 patients2011

    • Author(s)
      Koike T, Harigai M, Takeuchi T, Yamanaka H., et.al
    • Journal Title

      Ann Rheum Dis

      Volume: 70 Pages: 2148-2151

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Incidence and risk factors for serious infection in rheumatoid arthritis patients treated with tumor necrosis factor (TNF) inhibitors : a report from the registry of Japanese Rheumatoid Arthritis Patients for Long-Term Safety2011

    • Author(s)
      Komano Y, Koike T, Eguchi K, Tanaka Y, Takeuchi T, Miyasana N, Harigai M., et al
    • Journal Title

      J Rheum

      Volume: 38 Pages: 1258-1264

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] Treating Rheumatoid Arthritis to Target : multinational recommendatios assessment questionnaire2011

    • Author(s)
      Haraoui B, Smolen JS, Emery P, Takeuchi T, van der Heijde D, the Treat to Target Taskforce., et.al
    • Journal Title

      Ann Rheum

      Volume: 70 Pages: 1999-2002

    • DOI

      10.1136/ard.2011.154179

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Journal Article] IgG4-positive multi-organ lymphoproliferative syndrome manifesting as chronic symmetrical sclerosing dacryo-sialo-adenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation.2010

    • Author(s)
      Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nishi, E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Yasaki Y, Itoyama S, Tsuzaka K, Takeuchi T.
    • Journal Title

      Rheumatology

      Volume: 49 Pages: 1789-1791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] The comparison of efficacy and safety between continuation and discontinuation of methotrexate(MTX)at the commencement of etanercept in patients with active rheumatoid arthritis despite MTX therapy : 24-week results from the JESMR study.2010

    • Author(s)
      Kameda H, Ueki Y, Saito K, Nagaoka S, Hidaka T, Atsumi T, Tsukano M, Kasama T, Shiozawa S, Tanaka Y, Takeuchi T, Japan Biological Agent Integrated Consortium(J-BASIC).
    • Journal Title

      Rheumatology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Single Center Prospective Study of Tacrolimus Efficacy and Safety in Treatment of Various Manifestations in Systemic Lupus Erythematosus2010

    • Author(s)
      Suzuki K, Kameda H, Amano K, Nagasawa H, Takei H, Nishi E, Okuyama A, Tsuzaka K, Takeuchi T
    • Journal Title

      Rheumatology int

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] Efficacy and safety of cyclosporine A in patients with refractory systemic lupus erythematosus in a daily clinical practice.2010

    • Author(s)
      Ogawa H, Kameda H, Amano K, Takeuchi, T.
    • Journal Title

      Lupus 19

      Pages: 162-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Reduced expression of TCR zeta is involved in the abnormal production of cytokines by peripheral T cells of patients with systemic lupus erythematosus.2010

    • Author(s)
      Yoshimoto K, Setoyama Y, Tsuzaka K, Abe T, Takeuchi T.
    • Journal Title

      J Biomed Biotechnol

      Volume: Article ID 509021 Pages: 1-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] 新薬展望2010抗リウマチ薬2010

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      医薬ジャーナル増刊号(医薬ジャーナル社) Vol.46S-1

      Pages: 217-21

    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] ADAMTS5 is a biomarker for prediction of the response to Infliximab in patients with rheumatoid arthritis.2010

    • Author(s)
      Tsuzaka K, Itami Y, Takeuchi T, Shinozaki N, Morishita T
    • Journal Title

      J Rheumatol (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Efficacy and safety of cyclosporine A in patients with refractory systemic lupuserythematosus in a daily clinical practice.2010

    • Author(s)
      Ogawa H, Kameda H, Amano K, Takeuchi T.
    • Journal Title

      Lupus

      Volume: 19 Pages: 162-169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] IgG4-related systemic disease manifesting as Mikulicz disease with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation2010

    • Author(s)
      Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nish E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Sasaki Y, Itoyama S, Tsuzaka K, Takeuchi T
    • Journal Title

      Rheumatology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] IgG4-positive mufti-organ lymphoproliferative syndrome manife sting as chronic symmetrical sclerosing dacryo-sialo-adenitis with subsequent secondary portal hypertension and remarkable IgG4-linked IL-4 elevation.2010

    • Author(s)
      Suzuki K, Tamaru J, Okuyama A, Kameda H, Amano K, Nagasawa H, Nishi, E, Yoshimoto K, Setoyama Y, Kaneko K, Osada H, Honda N, Yasaki Y, Itoyama S, Tsuzaka K, Takeuchi T.
    • Journal Title

      Rheumatology (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] 新薬展望2010抗リウマチ薬2010

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      医薬ジャーナル増刊号(医薬ジャーナル社) 46S-1

      Pages: 217-21

    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] 特集臨床でわかったエビデンスType 1インターフェロンはループスだけの特徴か2009

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      分子リウマチ治療 vol.2,No.3

      Pages: 119-22

    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] Long-term safety and efficacy of tocilizumab, an anti-interleuk in(IL)-6 receptor monoclonal antibody, in monotherapy, in patients with rheumatoid arthritis(the STREAM study) : evidence of safety and efficacy in a 5-year extension study.2009

    • Author(s)
      Nishimoto N, Miyasaka N, Yamamoto K, Kawai S, Takeuchi T, Azuma J.
    • Journal Title

      Ann Rheum Dis 68

      Pages: 1580-1584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Two cases of acute exacerbation of lupus manifestation after re-treatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythe matosus.2009

    • Author(s)
      Suzuki K, Kameda H, Kondo K, Tanaka Y, Takeuchi T.
    • Journal Title

      Rheumatology 48

      Pages: 198-199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Single Center Prospective Study for Efficacy and Safety of Tacrolimus in Rheumatoid Arthritis.2009

    • Author(s)
      Suzuki K, Kameda H, Amano K, Nagasawa H, Sekiguchi H, Nishi E, Ogawa H, Tsuzaka K, Takeuchi T.
    • Journal Title

      Rheumatology Int 29

      Pages: 431-146

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Single Center Prospective Study of Tacrolimus Efficacy and Safety in Treatment of Rheumatoid Arthritis2009

    • Author(s)
      Suzuki K, Kameda H, Amano K, Nagasawa H, Takei H, Sekiguchi N, Nishi E, Ogawa H, Tsuzaka K, Takeuchi T
    • Journal Title

      Rheum. Int 29(4)

      Pages: 431-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] Impact to through serum level on Radiographic and Clinical Response to Infliximab plus Methotrexate in Patients with Rheumatoid Arthriti : results from the RISING Study.2009

    • Author(s)
      Takeuchi T, Miyasaka N, Inoue K, Abe T, Koike T
    • Journal Title

      Mod Rheumatology 19

      Pages: 478-487

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Prediction of efficacy of anti-TNF biologic agent, infliximab, for rheumatoid arthritis patients using a comprehensive transc riptome analysis of white blood cells.2009

    • Author(s)
      Tanino M, Matoba R, Nakamura S, Kameda H, Amano K, Okayama T, Nagasawa H, Suzuki K, Matsubara K, Takeuchi T.
    • Journal Title

      Biochem Biophys Research Comm 387

      Pages: 261-265

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Sever acute thrombotic exacerbation in two cases with of anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory syystemic lupus erythematosus.2009

    • Author(s)
      Suzuki K, Kameda H, Kondo K, Tanaka Y, Takeuchi T.
    • Journal Title

      Rheumatology 48巻

      Pages: 198-199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Severe acute thrombotic exacerbation in two cases with anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory systemic lupus erythematosus2009

    • Author(s)
      Suzuki K, Nagasawa H, Kameda H, Amano K, Kondo T, Itoyama S, Tanaka Y, Takeuchi T
    • Journal Title

      Rheumatology 48(2)

      Pages: 198-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] Two cases of acut e exacerbation of lupus manifestation a fter re-treatment with rituximab in pha se I/II clinical trial for refractory s ystemic lupus erythematosus.2009

    • Author(s)
      Suzuki K, Kameda H, Kondo K, Tanaka Y, Takeuchi T.
    • Journal Title

      Rheumato logy

      Pages: 198-199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Sever acute thrombotic exacerbation in two cases with of anti-phospholipid syndrome after retreatment with rituximab in phase I/II clinical trial for refractory syystemic lupus erythematosus. .2009

    • Author(s)
      Suzuki K, Kameda H, Kondo K, Tanaka Y, Takeuchi T.
    • Journal Title

      Rheumatology 48

      Pages: 198-199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] The conservative sequences in 3'UTR of TCRζ mRNA regulate the production of TCRζ and TCR/CD3 complex in SLE T cells.2008

    • Author(s)
      Tsuzaka K, Itami Y, Kumazawa C, Suzuki M, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T.
    • Journal Title

      Biochemical Biophysical Research Communications 367

      Pages: 311-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Effect of Interleukin 2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells.2008

    • Author(s)
      Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T.
    • Journal Title

      Cytokine 44巻

      Pages: 44-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Effect of Interleukin 2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF)in human peripheral blood mononuclear cells.2008

    • Author(s)
      Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
    • Journal Title

      Cytokine 44

      Pages: 44-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Effect of Interleukin 2 on synthesis of B cell activating factor belonging to the tumor necrosis factor family (BAFF) in human peripheral blood mononuclear cells2008

    • Author(s)
      Suzuki K, Setoyama Y, Yoshimoto K, Tsuzaka K, Abe T, Takeuchi T
    • Journal Title

      Cytokine 44(1)

      Pages: 44-8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] T The conservative sequences in 3' UTR of TCRtξ mRNA regulate the production of TCRξ and TCR/CD3 complex in SLE T cells.2008

    • Author(s)
      Tsuzaka, K, Itami, Y, Kumazawa, C, Suzuki, M, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
    • Journal Title

      BBRC 367

      Pages: 311-317

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] 特集リウマチ性疾患における腎障害ループス腎炎に対するタクロリムスの有用性2008

    • Author(s)
      鈴木勝也, 竹内勤
    • Journal Title

      リウマチ科 40(6)

      Pages: 604-7

    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] The conservative sequences in 3'UTR of TCRζ mRNA regulate the production of TCRζ and TCR/CD3 complex in SLE T cells.2008

    • Author(s)
      Tsuzaka K, Itami Y, Kumazawa C, Suzuki M, Setoyama Y, Yoshimoto K, Suzuki K, Abe T, Takeuchi T.
    • Journal Title

      Biochemical Biophysical Research Communications 367巻

      Pages: 311-317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Journal Article] Prospective study of low dose cyclosporine A in patients with refractory lupus nephritis2007

    • Author(s)
      Ogawa, H, Kameda, H, Nagasawa, H, Sekiguchi, N, Takei, H, Tsuzaka, K, Amano, K, d Takeuchi, T
    • Journal Title

      Mod Rheum 17

      Pages: 92-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] Down-regulation of Fas-ligand mRNA Shogren' syndrome patients with enlarged exocrine glands2007

    • Author(s)
      Tsuzaka, K, Matsumoto, Y, Sasaki, Y, Abe, T, Tsubota, K, Takeuchi, T
    • Journal Title

      Autoimmunity 40

      Pages: 497-502

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] A muticenter phase I/II trial of rituximab for refractory systemic lupus erythematosus2007

    • Author(s)
      Tanaka, Y, Yamamoto, K, Takeuchi, T, Nishimoto, N, Miyasaka, N, Sumida, T, Shima, Y, Takada, K, Matsumoto, I, Saito, K, Koike, T
    • Journal Title

      Mod Rheum 17

      Pages: 191-7

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] Efficacy and Safety of Tacrolimus in Patients with rheumatoid arthritis in clinical practice : Significant role of blood concentration measurement for preventing severe adverse events2007

    • Author(s)
      Suzuki, K, Takei, H, Kameda, H, Nagasawa, H, Sekiguchi, N, Nishi, E, Ogawa, H, Tsuzaka, K, Amano, K, Takeuchi, T
    • Journal Title

      Arthritis Rheum S 35

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] 話題クラスター分類の最新の情報2007

    • Author(s)
      鈴木勝也, 瀬戸山由美子, 竹内勤
    • Journal Title

      臨床検査 51(9)

      Pages: 983-5

    • Data Source
      KAKENHI-PROJECT-19591177
  • [Journal Article] Platelet-Derived Growth Factor as a Therapeutic Target for systemic autoimmune diseases2007

    • Author(s)
      Kameda, H, Takeuchi, T
    • Journal Title

      Drug Target Insight 2

      Pages: 1-9

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] DNA microarray gene expression profile of T cells with splice variants of TCRz mRNA observed in SLE2006

    • Author(s)
      Tsuzaka, K, Nozaki, K, Kumazawa, C, Shiraishi, K, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
    • Journal Title

      J Immunol 176

      Pages: 949-56

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] TCRz mRNA splice variant forms observed in peripheral blood T cells from systemic lupus erythematosus patients2006

    • Author(s)
      Tsuzaka, K, Nozaki, K, Kumazawa, C, Shiraishi, K, Setoyama, Y, Yoshimoto, K, Abe, T, Takeuchi, T
    • Journal Title

      Springer Seminars in Immunopathology 28

      Pages: 185-93

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] Molecular abnormalities of T cells in systemic lupus erythematosus2006

    • Author(s)
      Takeuchi, T, Tsuzaka, T, Kameda, H, Amano, K
    • Journal Title

      APLAR journal of Rheum 9

      Pages: 365-71

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] Imatinib mesylate inhibits proliferation of rheumatoid synovial fibloblast-like cells and phosphorylation of Gab adaptor proteins activated by platelet-derived growth factor2006

    • Author(s)
      Kameda, H, Ishigami, H, Suzuki, M, Abe, T, Takeuchi, T
    • Journal Title

      Clin Exp Immunol 144

      Pages: 335-41

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy2006

    • Author(s)
      Yoshimoto, K, Takahashi, Y, Ogasawara, M, Setoyama, Y, Suzuki, K, Tsuzaka, K, Abe, T, Takeuchi, T
    • Journal Title

      Int Immunol 18

      Pages: 1189-96

    • NAID

      10020618413

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] Recent advance in the treatment of interstitial lung disease in patients with polymyositis/dermatomyositis2006

    • Author(s)
      Kameda, H, Takeuchi, T
    • Journal Title

      Endocrine, metabolic & Immune disorders- Drug Targets 6

      Pages: 409-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Journal Article] T cell abnormalities in systemic lupus erythematosus2005

    • Author(s)
      Takeuchi, T, Tsuzaka, K, Abe, T, et. al.
    • Journal Title

      Autoimmunity 38

      Pages: 339-346

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590993
  • [Journal Article] Therapeutic targets in misguided T cells in systemic lupus erythematosus.2005

    • Author(s)
      Takeuchi T, Tsuzaka K, Kameda H, et al.
    • Journal Title

      Current Drug Target 4

      Pages: 295-298

    • Data Source
      KAKENHI-PROJECT-16590993
  • [Journal Article] Therapeutic targets in misguided T cells in systemic lupus erythematosus2005

    • Author(s)
      Takeuchi, T, Tsuzaka, K, Kameda, H, et. al.
    • Journal Title

      Current Drug Target 4

      Pages: 295-298

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590993
  • [Journal Article] T cell abnormalities in systemic lupus erythematosus.2005

    • Author(s)
      Takeuchi T, Tsuzaka K, Abe T, et al.
    • Journal Title

      Autoimmunity 38

      Pages: 339-346

    • Data Source
      KAKENHI-PROJECT-16590993
  • [Journal Article] Altered expression of the T cell receptor-CD3 complex in systemic lupus erythematosus.2004

    • Author(s)
      Takeuchi T, Tsuzaka K, Abe T
    • Journal Title

      Int Rev Immunol 23

      Pages: 273-291

    • Data Source
      KAKENHI-PROJECT-16590993
  • [Journal Article] SLE発症前の自己抗体2004

    • Author(s)
      津坂憲政, 竹内勤
    • Journal Title

      内科 93

      Pages: 972-973

    • Data Source
      KAKENHI-PROJECT-16590993
  • [Journal Article] Structural damages disturb functional improvement in patients with rheumatoid arthritis treated with etanercept

    • Author(s)
      Tanaka Y, Yamanaka H, Amano K, Takeuchi T., et.al
    • Journal Title

      Mod Rheumatology

      Volume: (In press)

    • NAID

      10030614929

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Patent] 自己免疫疾患の検出剤となるタンパク質複合体、及びその使用2019

    • Inventor(s)
      竹下 勝、竹内 勤、鈴木 勝也
    • Industrial Property Rights Holder
      竹下 勝、竹内 勤、鈴木 勝也
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-107179
    • Filing Date
      2019
    • Data Source
      KAKENHI-PROJECT-17H04216
  • [Patent] 関節リウマチ活動性指標を同定する方法及びそれに用いるバイオマーカー2011

    • Inventor(s)
      竹内勤, 天野宏一, 石澤洋平, 中村誠二, 谷野元彦, 羽田裕子
    • Industrial Property Rights Holder
      学校法人慶應義塾, 学校法人埼玉医科大学, 株式会社DNAチップ研究所
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-11-17
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Patent] 関節リウマチ活動性指標を同定する方法及びそれに用いるバイオマーカー2011

    • Inventor(s)
      竹内勤(慶應義塾大学), 天野宏一(埼玉医科大学), 石澤洋平, 中村誠二, 谷野元彦, 羽田裕子((株)DNAチップ研究所)
    • Industrial Property Rights Holder
      学校法人慶應義塾, 学校法人埼玉医科大学, 株式会社DNAチップ研究所
    • Filing Date
      2011-11-17
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] Transcriptome analysis of alveolar macrophages identifies involvement of PD-1/PD-Ls in pathogenesis of rheumatoid arthritis-associated interstitial lung disease.2021

    • Author(s)
      Maho Nakazawa, Katsuya Suzuki, Masaru Takeshita, Jun Inamo, Tsutomu Takeuchi.
    • Organizer
      第65回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20H03720
  • [Presentation] Differences of coinhibitory molecule expression on lung T cells from patients with rheumatoid arthritis- and idiopathic inflammatory myopathies-associated interstitial lung disease.2020

    • Author(s)
      Maho Nakazawa, Masaru Takeshita, Katsuya Suzuki, Hisaji Oshima, Tsutomu Takeuchi.
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20H03720
  • [Presentation] Antigen-driven autoantibody production in lung lesion of systemic autoimmune diseases.2020

    • Author(s)
      Masaru Takeshita, Katsuya Suzuki, Maho Nakazawa, Tsutomu Takeuchi.
    • Organizer
      第64回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20H03720
  • [Presentation] シェーグレン症候群の病変局所における自己抗体産生から明らかになった抗セントロメア抗体の疾患分類上の意義について2019

    • Author(s)
      竹下 勝、鈴木 勝也、金田 由加梨、山根 史嗣、池浦 一裕、佐藤 秀和、加藤 伸、角田 和之、荒瀬 尚、竹内 勤
    • Organizer
      第6回JCRベーシックリサーチカンファレンス
    • Data Source
      KAKENHI-PROJECT-17H04216
  • [Presentation] Reactivity of antibodies in the salivary glands of Sjögren's syndrome reveals affinity maturation in disease lesion and the significance of anti-centromere “complex” antibody in disease classification.2019

    • Author(s)
      Masaru Takeshita, Katsuya Suzuki, Tsutomu Takeuchi.
    • Organizer
      第48回日本免疫学会
    • Data Source
      KAKENHI-PROJECT-17H04216
  • [Presentation] シェーグレン症候群の唾液腺における自己抗体産生2018

    • Author(s)
      竹下 勝、鈴木 勝也、竹内 勤
    • Organizer
      第62回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-17H04216
  • [Presentation] DNAマイクロアレイ解析を用いた生物学的製剤のテーラーメイド医療へのアプローチ2014

    • Author(s)
      鈴木勝也、竹内 勤
    • Organizer
      第29回日本臨床リウマチ学会
    • Place of Presentation
      福岡国際会議場3F メインホール
    • Year and Date
      2014-11-30
    • Data Source
      KAKENHI-PROJECT-26293233
  • [Presentation] トランスクリプトミクスのリウマチ性疾患への応用2013

    • Author(s)
      鈴木勝也、竹内勤
    • Organizer
      第8回北海道ヤングアカデミー
    • Place of Presentation
      北海道 北広島
    • Invited
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] トランスクリプトミクスのリウマチ性疾患への応用2013

    • Author(s)
      鈴木勝也, 竹内勤
    • Organizer
      第8回北海道ヤングアカデミー
    • Place of Presentation
      北広島
    • Year and Date
      2013-07-19
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] DNAマイクロアレイを用いた関節リウマチ新規活動性マーカーの探索2013

    • Author(s)
      鈴木勝也、中村誠二、谷野元彦、竹下勝、吉本桂子、亀田秀人、天野宏一、竹内勤
    • Organizer
      第56回日本リウマチ学会学術集会
    • Place of Presentation
      京都国際会館
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] DNAマイクロアレイを用いた関節リウマチ新規活動性マーカーの探索2013

    • Author(s)
      鈴木勝也, 中村誠二, 谷野元彦, 竹下勝, 吉本桂子, 亀田秀人, 天野宏一, 竹内勤
    • Organizer
      第56回日本リウマチ学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2013-04-18
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] 関節リウマチの新たなバイオマーカー2012

    • Author(s)
      鈴木勝也, 竹下勝, 竹内勤
    • Organizer
      第2回TNF療法研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-10-18
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] 関節リウマチの治療と新たな分子標的の探索2012

    • Author(s)
      竹内勤, 鈴木勝也
    • Organizer
      基盤研究所セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2012-01-12
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] Application of transcriptomics for systemic lupus erythematosus pathogenesis analysis2012

    • Author(s)
      鈴木勝也, 竹内勤
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-12
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] RA患者における日常診療下でのTocilizumabの有効性と安全性-the REACTION study 52週と全例調査報告から-イブニングセミナー2011

    • Author(s)
      竹内勤
    • Organizer
      第55回日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] 生物学的製剤スイッチングの意義イブニングセミナー2011

    • Author(s)
      竹内勤
    • Organizer
      第55回日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2011-07-19
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] RAの治療:新しい生物学的製剤治療抵抗性関節リウマチに対するゴリムマブ(GLM:ヒト抗TNFαモノクローナル抗体)単剤療法:52週までの有効性/安全性の解析結果ワークショップ112011

    • Author(s)
      竹内勤
    • Organizer
      第55回日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2011-07-18
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] Golimumab, a human anti-TNF-α monoclonal antibody administered subcutaneously every four weeks as monotherapy in patients with active rheumatoid arthritis despitemethotrexate therapy : 4 week results of clinical and radiographic assessments2011

    • Author(s)
      Tanaka Y, Harigai M, Takeuchi T, Yamanaka H, Ishiguro N, Yamamoto K, et al
    • Organizer
      The annual European congress of rheumatology 2011
    • Place of Presentation
      London, England
    • Year and Date
      2011-05-26
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] Targeting interferon-alpha and IL-17 in systemic autoimmune diseases. Main Symposium 1.[Novel targets for the treatment of inflammatory diseases]2011

    • Author(s)
      Takeuchi T.
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-06-02
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] アバタセプトの最新知見-国内外の臨床試験成績から-スポンサードシンポジウム2011

    • Author(s)
      竹内勤
    • Organizer
      第55回日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2011-07-20
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] 免疫難病における新しいターゲット分子と制御2009

    • Author(s)
      竹内勤
    • Organizer
      第37回日本臨床免疫学会総会 シンポジウム3
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Presentation] The expression of an integrin α Eβ7 may induce abnormal T cell activation.2008

    • Author(s)
      K. Yoshimoto, C. Kumazawa, K. Tsuzaka, T. Abe, T. Takeuchi.
    • Organizer
      9th annual meeting for European League Aginst Rheumatisam
    • Place of Presentation
      フランス(パジ)
    • Year and Date
      2008-06-14
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Presentation] The expression of an integrin αEβ7 may induce abnormal T cell activation.2008

    • Author(s)
      K. Yoshimoto, C. Kumazawa, K. Tsuzaka, T. Abe, T. Takeuchi
    • Organizer
      9th annual meeting for European League Aginst Rheumatisam
    • Place of Presentation
      フランス(パリ)
    • Year and Date
      2008-06-14
    • Data Source
      KAKENHI-PROJECT-20591193
  • [Presentation] 14-kd protein binds to the conservative region in TCR zeta mRNA 3' UTR and regulates the production of TCR zeta and TCR/CD3 complex2007

    • Author(s)
      Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
    • Organizer
      American College of Rheumatology 71st Annual Meeting
    • Place of Presentation
      Boston, U. S. A
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Reguratory T cells and FOXP3 isoform expression in patients with systemic lupus erythematosus and rheumatoid arthritis2007

    • Author(s)
      Suzuki K, Setoyama Y, Suzuki M, Yoshimoto K, Kameda H, Tsuzaka K, Amano K, Takeuchi T
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2007-11-21
    • Data Source
      KAKENHI-PROJECT-19591177
  • [Presentation] A negative role of a unique integrin alphaEbeta7 on proliferative capability of human T cell line2007

    • Author(s)
      Kumazawa, C, Shiraishi, K, Tsuzaka, K, Takeuchi, T
    • Organizer
      The EULAR annual congress of rheumatology
    • Place of Presentation
      Barcelona, Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Possible involvement of MMP in the production of soluble BAFF in human T cells2007

    • Author(s)
      Yoshimoto, K, Takahashi, Y, Setoyama, Y, Suzuki, K, Tsuzaka, K, Abe, T, Takeuchi, T
    • Organizer
      The EULAR annual congress of rheumatology, Barcelona
    • Place of Presentation
      Spain
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Efficacy and safety of tacrolimus in patients with rheumatic disease : Appropriate clinical application for various rheumatic conditions2007

    • Author(s)
      Suzuki, K, Kameda, H, Amano, K, Nagasawa, H, Sekiguchi, N, Takei, H, Nishi, E, Okuyama, A, Ogawa, H, Tsuzaka, K, Takeuchi, T
    • Organizer
      American College of Rheumatology 71st Annual Meeting
    • Place of Presentation
      Boston, U. S. A
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Signaling defects and the consequences in Lupus T cells2007

    • Author(s)
      Tsutomu, Takeuchi
    • Organizer
      2007 CIS School in Systemic Autoimmune Diseases
    • Place of Presentation
      Santa Fe, New Mexico
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Decreased expression of the glycosylated syndecan 4 accompanied with down-regulation of TCR zeta in SLE patient T cells2007

    • Author(s)
      Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
    • Organizer
      American College of Rheumatology 71st Annual Meeting
    • Place of Presentation
      Boston, U. S. A
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] TCR ξ and TCR/CD3 expression from the TCR C mRNA with deleted form of the conservative sequences in 3' UTR is down-regulated due to its instability2007

    • Author(s)
      Tsuzaka, K, Itami, Y, Kumazawa, C, Setoyama, Y, Yoshimoto, K, Suzuki, K, Abe, T, Takeuchi, T
    • Organizer
      37th Japanese society for Immunology
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Possible involvement of MMP-9 in the production of BAFF in T cells2007

    • Author(s)
      Yoshimoto, K, Setoyama, Y, Tsuzaka, K, Ogawa, Y, Tsubota, K, Abe, T, Takeuchi, T
    • Organizer
      American uollege of Nheumatology Ylst Annual Meeting
    • Place of Presentation
      Boston, U. S. A
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Efficacy and Safety of Tacrolimus in Patients With Rheumatoid Arthritis in Clinical Practice : Significant Role of Blood Concentration Measurement for Preventing Severe Adverse Events2006

    • Author(s)
      Suzuki, K, Takei, H, Kameda, H, Nagasawa, H, Sekiguchi, N, Nishi, E, Ogawa, H, Tsuzaka, K, Amano, K, Takeuchi, T
    • Organizer
      70th Annual Meeting, Washington
    • Place of Presentation
      D. C., U. S. A
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Responsible region in 3'UTR of TCRz mRNA for producing TCR/CD3 including TCRz in SLE T cells2006

    • Author(s)
      Tsuzaka, K, Nozaki, K, Kumazawa, C, Setoyama, Y, Shiraishi, K, Abe, T, Takeuchi, T
    • Organizer
      16th European Congress of Immunology
    • Place of Presentation
      Paris, France
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Aberrant expression of BAFF in SLE T cells2006

    • Author(s)
      Yoshimoto, K, Takahashi, Y, Setoyama, Y, Suzuki. K, Tsuzaka. K, Abe. T, Takeuchi, T
    • Organizer
      The EULAR annual congress of rheumatology
    • Place of Presentation
      Amsterdam, Holland
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Responsible regin in 3'UTR of TCRz mRNA for producing TCR/CD3 inclluding TCRa in SLE T cells2006

    • Author(s)
      Tsutomu, Takeuchi
    • Organizer
      16th European Congress off Immunology
    • Place of Presentation
      SLE T cells
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Efficacy and Safety of Tacrolimus in Patients with rheumatoid arthritis in clinical practice : Significant role of blood concentration measurement for preventing severe adverse events2006

    • Author(s)
      Tsutomu, Takeuchi
    • Organizer
      American College of Rheumatology 70th ACR Annual Meeting
    • Place of Presentation
      Washington DC, USA
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18591122
  • [Presentation] Identification of transcriptomewide gene expression signature on peripheral blood mononuclear cells from systemic lupus erythematosus and rheumatoid arthritis patients by high-throughput DNA sequencer

    • Author(s)
      Suzuki K, Yoshimoto K, Takeshita M,Takeuchi T
    • Organizer
      第42回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-23390259
  • [Presentation] SLE末梢血におけるトランスクリプトームワイドの遺伝子発現解析

    • Author(s)
      鈴木勝也、吉本桂子、倉沢隆彦、竹下勝、竹内勤
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-23390259
  • 1.  TSUZAKA Kensei (00245490)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 2.  AMANO Koichi (00175928)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 7 results
  • 3.  SUZUKI Katsuya (70306695)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 36 results
  • 4.  ABE Tohru (60051207)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIMOTO Keiko (20383292)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 20 results
  • 6.  TAKESHITA Masaru (10571135)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 9 results
  • 7.  KOIDE Jun (70178193)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  MATSUYAMA Takami (30145479)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  KAMEDA Hideto (00265795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 12 results
  • 10.  NAGASAWA Hayato (20306343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 11.  MORI Sigehisa (10190993)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HOSONO Osamu (50190210)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAKANO Makoto (90101021)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  Yamaoka Kunihiro (20425317)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  江口 勝美 (30128160)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  佐々木 毅 (50110656)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  小池 隆夫 (80146795)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  長澤 浩平 (00108721)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  宮坂 信之 (30157622)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  中川 種昭 (00227745)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  仲 哲治 (30303936)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 22.  白石 清之 (10383291)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  浅川 修一 (30231872)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  近藤 泰 (50626380)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  金子 祐子 (60317112)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 26.  津坂憲 政
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 25 results
  • 27.  角田 和之
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 28.  荒瀬 尚
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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