HIROSE Shigehisa 広瀬茂久

… Alternative Names

廣瀬茂久ヒロセシゲヒサ

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Researcher Number	10134199
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2013: 桐蔭横浜大学, 医用工学部, 客員研究員 2012 – 2013: 東京工業大学, 生命理工学研究科, 教授 2000 – 2012: 東京工業大学, 大学院・生命理工学研究科, 教授 2006: Tokyo Institute of Technology, Department of Biological Sciences, Professor, 大学院生命理工学研究科, 教授 1990 – 1999: Department of Biological Sciences, Tokyo Institute of Technology. Professor, 生命理工学部, 教授 … More 1997: 東工大, 生命理工学部, 教授 1994: 東京工業大学, 生命理工学部生体機構学科, 教授 1986 – 1992: 東京工業大学, 理学部, 教授 1988: DEPARTMENT OF CHEMISTRY, TOKYO INSTITUTE OF TECHNOLOGY 1988: 東京工業大学, 理学部, 助教授 1988: 東京工業大学, 理学部化学科, 教授 1987: 東京工業大学, 理学部・化学科, 教授 1986: 東京工大, 理学部, 教授 Less
Review Section/Research Field	Principal Investigator Biological Sciences / 医学一般 / Functional biochemistry / Structural biochemistry / Biomedical engineering/Biological material science / Structural biochemistry / Animal physiology/Animal behavior / 生物形態・構造 Except Principal Investigator 内分泌・代謝学 / 物質生物化学 … More / Animal physiology/Animal behavior / Hematology / 固体地球物理学 / Genome biology Less
Keywords	Principal Investigator エラフィン / トランスグルタミナーゼ / セメントイン / GPCR / Ig-Hepta / 塩類細胞 / ゼブラフィッシュ / 心房性ナトリウム利尿ホルモン / 血圧 / 内皮細胞 … More / プロテアーゼ / インヒビター / 接着型インヒビター / プロテアーゼインヒビター / インサイチュハイブリダイゼーション / プロモーター / オリゴペプチダーゼ / 膜7回貫通型受容体 / LNB-TM7 / プロセッシング / furin / EGF2 / SEA module / エンドセリン / 心臓 / V-ATPase / コネキシン / 転写因子 / Carbonic anhydrase / GFP / 受容体 / ノックアウトマウス / マクロファージ / 海水適応 / アンジオテンシン【II】 / リセプター / アンジオテンシンII / レセプター / レセプター抗体 / Radiation Inactivation / ANP / ANP受容体 / クローニング / サブタイプ / ウナギ / receptor / Crosslinking / Transglutaminase / Glue / Cementoin / 遺伝子 / ナトリウム利尿ペプチド / 酸性適応 / foxi3a / 心房性ナトリウム利尿ペプチド / 免疫組織化学 / ラジオイムノアッセイ / 気道上皮細胞 / 小腸の陰窩 / クリプト / エンテロエンドクリン細胞 / 抗体染色 / ニューロリシン / 細胞内局在 / ミトコンドリア移行シグナル / カルシトニン受容体 / ホルモン結合ドメイン / ドミナントネガティブ / 赤血球 / フグ / アドレノメデュリン / アミリン / CGRP / RAMP / CLR / イオン輸送 / アンモニア / 重炭酸イオン / Na取り込み / 筋原繊維 / 骨格筋 / 横紋筋 / アンチセンスモフホリノ / 先天性疾患 / シグナル伝達 / サーファクタント / 肺胞細胞 / 生合成 / 動物生理化学 / ホウ酸 / 輸送体 / Slc4a11 / アクアポリン / AQP / 魚類 / 近位尿細管 / メフグ / 硫酸イオン輸送体 / 腎臓 / ホウ酸イオン輸送体 / Slc26a6A / 局在部位 / 脂質 / タンパク質 / 糖鎖 / 細胞膜 / 脂質ラフト / ガングリオシド / GOTO細胞 / モノクローナル抗体 / フロチリン / エンドサイトーシス / 神経芽腫 / シクロデキストリン / GM2 / 肺胞サーファクタント / SP-D / GPR116 / 活性酸素 / NFkB / 炎症性サイトカイン / BALF / 酵素の調節 / 代謝調節 / ルート効果ヘモグロビン / 解糖系 / 乳酸輸送体 / Fructose bisphosphatase / 空転サイクル / 熱発生 / 対向流血管系 / ガス腺 / sABP / オリゴペプチターゼ / エンドセリン受容体 / SABP / 点突然変異体 / ジスルフィド結合 / 免疫組織化学染色 / 情報伝達系 / 択一的RNAスプライシング / 分子生物学 / 軟骨組織 / natriuretic peptide / subtype / endothelin / chondrocyte / cloning / oligopeptidase / タンパク質工学 / 接着分子 / バイオコンジュゲート / ハイブリッド / タンパク質の接着 / 内在性接着因子 / Elafin / タンパク質の糊付け / トラッピン / アルツハイマー病 / ランダムコイル / 二次構造 / WAP / Trappin / Green fluorescent protein / Gene conversion / Evolution / 循環調節 / カリウムチャネル / 広塩性魚類 / ウグイ / クローディン / 内向き整流性Kチャネル / 恐山 / Osmoregulation / Natriuretic peptide / Chloride cell / Eel / Dace / Acid adaptation / K channel / 淡水適応 / イオン輸送体 / 尿素輸送体 / アンモニア輸送体 / 転写調節因子 / 淡水型塩類細胞 / Delta-notch / Sodium Green / Na感受性蛍光色素 / ミトコンドリア / 細胞内トラフィック / エラ / 柱細胞 / pillar cell / 恐山ウグイ / 酸性適応機構 / トランスポーター / RBCCタンパク質 / グルタミン代謝 / chloride cell / Osorezan dace / mitochondria / acid adaptation / channel / transporter / mitochondria-rich cell / リセプター抗体 / 心房性ナトリウケ利尿ホルモン / Radiation lnactivation / Angiotensin II / Atrial natriuretec peptide / Blld pressure / Auti-receptor antibody / サイクレ-ス / サブユニット / オリゴマ- / エクソンシャッフリング / グアニレ-トサイクレ-ス / 原発性アルドステロン症 / Atrial natriuretic peptide / Receptor / Subtype / Subunit / Subtype switching / Immunohistochemistry / Purification / Gene … More Except Principal Investigator 血栓 / 血管内皮細胞 / 心房性ナトリウム利尿ペプチド / エンドセリン / 平滑筋細胞 / 線維素溶解現象 / トロンボモジュリン / 血管新生 / 血管壁収縮因子 / 血管壁弛緩因子 / ナトリウム利尿ペプチド / 高血圧 / 受容体 / 血栓症 / 血栓性素因 / レニン / アルドステロン / mRNA / ナトリウム利尿ペプチド受容体 / 糖尿病 / 受容体サブタイプ / 血管壁 / ガスチャネル / アクアポリン / 鰾 / フグゲノム / 乳酸輸送体 / グルコース輸送体 / ガス腺細胞 / 奇網 / 血液凝固 / 血液凝固制御調節機構 / 線溶 / 遺伝 / 未知の生理活性ペプチド / 生体内情報伝達 / 遺伝子及び生合成 / レセプター分泌 / アンジオテンシンII / 生理活性ペプチド / 体液 / 循環 / 血圧 / アンジオテンシン / ANP / 凝固 / 線維素溶解 / 増殖因子 / 血管平滑筋 / 高血圧治療薬 / 高血圧性心血管給併症 / 喫煙 / 交感神経系 / レニン・アンジオテンシン・アルドステロン系 / 心房性ナトリウム利尿ホルモン / ファイブロネクチン / プロスタグラジン / フィブロネクチン / アンジオテンシン変換酵素 / 血管障害 / 動脈硬化 / Hypertension / Hypertensive vascular complications / Glucose and lipids metabolism / Smoking / Muscle sympathetic nerve activity / Renin-angiotensin-aldosterone system / Primary aldosteronism / Atrial natriuretic peptide receptors / Endothelin receptors / Fibronectin / 糸球体限外濾過 / 糸球体上皮細胞 / 腎糸球体 / 限外濾過 / 形態計測法 / マイクロパンクチャ-法 / Glomerular ultrafiltration / Glomerular epithelial cell / Atrial natriuretic peptide / Receptor / 走磁性バクテリア / N極 / S極 / 磁力線 / 磁場勾配 / 培養 / 走磁性微生物 / Magnetotactic bacteria / N pole / S pole / Magnetic field line / Magnetic gradient / Cultivation / 僧帽弁疾患 / 心房内圧 / 心房細動 / 存在様式 / 僧帽弁膜疾患 / 生合成 / モノクロタリン / 肺動脈高血圧症 / ATRIAL NATRIURETIC PEPTIDE / MITRAL DISEASE / ATRIAL PRESSURE / ATRIAL FIBRILLATION / 比較ゲノム / 無胃魚 / 胃 / 胃酸 / 壁細胞 / 生理学 / 発生・分化 / 進化 Less

肺胞内で異物を捕捉するレクチン様蛋白質ＳＰーＤによる受容体を介した炎症制御機構Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Toin University of Yokohama
  Tokyo Institute of Technology
A metabolic futile cycle is operating in gas gland cells of the swimbladder.Principal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Institute of Technology
Identification of novel gastric systems by comparing genomic sequences between stomachless fishes and true stomach fishes
- Principal Investigator
  
  Kato Akira
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genome biology
- Research Institution
  Tokyo Institute of Technology
Identification of oxygen gas channels involved in gas secretion into the swimbladder
- Principal Investigator
  
  KATO Akira
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Tokyo Institute of Technology
Identification of transporters involved in excretion of toxic sulfate and borate by seawater fishPrincipal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Animal physiology/Animal behavior
- Research Institution
  Tokyo Institute of Technology
Visualization and characterization of GM2-rich lipid raft microdomainPrincipal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology
新発見の粘度センサーの作用機構Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
初期の筋繊維形成の足場となる配向決定因子の同定Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology
ゼブラフィッシュのイオン輸送系変異体を用いたトランスポートソームの解析Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
新発見の多価ホルモン受容体の構造と機能及び生理学的意義Principal Investigator
- Principal Investigator
  
  広瀬茂久 (廣瀬茂久)
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Institute of Technology
新規プロセッシング酵素の探索Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Tokyo Institute of Technology
Molecular characterization of chloride cells and their mechanism of differentiationPrincipal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  生物形態・構造
- Research Institution
  Tokyo Institute of Technology
新発見の接着型プロテアーゼインヒビターとがん細胞の浸潤・転移Principal Investigator
- Principal Investigator
  
  廣瀬茂久
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
プロモーター部位の使い分けによるプロテアーゼの細胞内局在化機構Principal Investigator
- Principal Investigator
  
  廣瀬茂久
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
Comparative molecular biology of the natriuretic peptide system (Molecular dissection and mechanism of differentiation of chloride cells)Principal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  1997 – 2001
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Institute of Technology
新発見の接着型プロテアーゼインヒビターとがん細胞の浸潤・転移Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
プロモーター部位の使い分けによるプロテアーゼの細胞内局在化機構Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
Development of protein crosslinking technology using the newly found family transglutaminase substrates termed cementoinPrincipal Investigator
- Principal Investigator
  
  SUZUKI Yoko, 広瀬茂久
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
新発見の接着型プロテアーゼインヒビターとがん細胞の浸潤・転移Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
血管壁ナトリウム利尿ペプチド受容体のサブタイプとCNPの病態生理学的意義
- Principal Investigator
  
  成瀬光栄
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Women's Medical University
ナトリウム利尿ペプチド受容体のサブタイプスイッチングの病態生理学的意義
- Principal Investigator
  
  NARUSE Mitsuhide
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Tokyo Women's Medical University
Developemt of protein crosslinking technology using the newly found transglutaminase substrate termed cementoin.Principal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
Comparative molecular biological studies on the vasoactive peptide receptors.Principal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  1992 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  医学一般
- Research Institution
  Tokyo Institute of Technology
血管内皮細胞由来の血栓調節因子の機能解析
- Principal Investigator
  
  居石克夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Regulation of Glomerular Ultrafiltration by Glomerular Epithelial Cells
- Principal Investigator
  
  YAMAMOTO Tadashi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Niigata University
Study on magnetic analyses by magnetotactic bacteria
- Principal Investigator
  
  FUNAKI Minoru
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  固体地球物理学
- Research Institution
  National Institute of Polar Research
血管内皮細胞由来の血栓調節因子の機能解析
- Principal Investigator
  
  居石克夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Relationship between the hypertensive vascular degeneration and endogeneous vasoactive peptides.
- Principal Investigator
  
  SHIONOIRI Hiroshi
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Yokohama City University
生体的情報伝達に係わる新しい物質の探索とその生理的及び臨床的意義の解明
- Principal Investigator
  
  井村裕夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  Kyoto University
血管内皮細胞由来の血栓調節因子の機能解析
- Principal Investigator
  
  居石克夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Mechanism of Action of Atrial Natriuretic Peptide (ANP)Principal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医学一般
- Research Institution
  Tokyo Institute of Technology
アンジオテンシンIIリセプターの単離とcDNAクローニングによる構造決定Principal Investigator
- Principal Investigator
  
  広瀬茂久
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tokyo Institute of Technology
生体内情報伝達に係わる新しいペプチドの探索とその生理的及び臨床的意義の解明
- Principal Investigator
  
  松尾壽之
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  物質生物化学
- Research Institution
  宮崎医科大学
血栓性素因の分子生物学的解析とその臨床応用
- Principal Investigator
  
  青木延雄
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Tokyo Medical and Dental University
ELUCIDATION OF PATHOPHYSIOLOGICAL SIGNIFICANCE OF ATRIAL NATRIURETIC PEPTIDE
- Principal Investigator
  
  NARUSE Mitsuhide
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  TOKYO WOMEN'S MEDICAL COLLEGE
アンジオテンシンIIリセプターの単離とcDNAクローニングによる構造決定Principal Investigator
- Principal Investigator
  
  廣瀬茂久
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tokyo Institute of Technology
血栓に関与する因子の遺伝的支配に関する研究
- Principal Investigator
  
  青木延雄
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Hematology
- Research Institution
  Tokyo Medical and Dental University
血管作動物質の生成と作用機構
- Principal Investigator
  
  山野俊雄
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Osaka University
Elucidation of the structure of angiotensin II receptor and its application to drug designPrincipal Investigator
- Principal Investigator
  
  HIROSE Shigehisa
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  医学一般
- Research Institution
  Tokyo Institute of Technology
  University of Tsukuba

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002

All Journal Article Presentation

[Journal Article] Expression of a novel isoform of Na^+/H^+ exchanger 3 in the kidney and intestine of banded houndshark, Triakisscyllium2013
- Author(s)
  Li S, Kato A, Takabe S, Chen AP, Romero MF, Umezawa T, Nakada T, Hyodo S, Hirose S.
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol
  
  Volume: 304 Issue: 10 Pages: R865-R876
- DOI
  10.1152/ajpregu.00417.2012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] 魚類のイオンホメオスタシス維持機構2012
- Author(s)
  広瀬茂久
- Journal Title
  
  生化学
  
  Volume: 84 Pages: 821-828
- NAID
  10031122388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] O_2-filled swimbladder employs monocarboxylate transporters for the generation of O_2 by lactate-induced Root effect hemoglobin2012
- Author(s)
  Umezawa T, Kato A, Ogoshi M, Ookata K, Doi H, Romero MF, Hirose S
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 4 Pages: e34579-e34579
- DOI
  10.1371/journal.pone.0034579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22870020, KAKENHI-PROJECT-23657054, KAKENHI-PROJECT-24657085
[Journal Article] Euryhaline pufferfish NBCe1 differs from nonmarine species NBCe1 physiology2012
- Author(s)
  Chang MH, Plata C, Kurita Y, Kato A, Hirose S, Romero MF
- Journal Title
  
  Am J Physiol Cell Physiol
  
  Volume: 302 Issue: 8 Pages: C1083-C1095
- DOI
  10.1152/ajpcell.00233.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] Histological demonstration of glucose transporters, fructose-1, 6-bisphosphatase, and glycogen in gas gland cells of the swimbladder : is a metabolic futile cycle operating2012
- Author(s)
  Munakata K, Ookata K, Doi H, Baba O, Terashima T, Hirose S, Kato A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 417 Issue: 1 Pages: 564-9
- DOI
  10.1016/j.bbrc.2011.12.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23657054, KAKENHI-PROJECT-24657085
[Journal Article] Identification and apical membrane localization of an electrogenic Na^+/Ca^2^+ exchanger NCX2a likely to be involved in renal Ca^2^+ excretion by seawater fish2011
- Author(s)
  Islam Z, Kato A, Romero MF, Hirose S
- Journal Title
  
  Am J Physiol Regul Integr Comp Physiol
  
  Volume: 301 Issue: 5 Pages: R1427-R1439
- DOI
  10.1152/ajpregu.00165.2011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] Differential expression of Na^+-Cl^- cotransporter and Na+-K^+^-Cl^- cotransporter 2 in the distal nephrons of euryhaline and seawater pufferfishes2011
- Author(s)
  Kato A, Muro T, Kimura Y, Li S, Islam Z, Ogoshi M, Doi H, Hirose S.
- Journal Title
  
  Am J Physiol Regul IntegrComp Physiol
  
  Volume: 300 Issue: 2 Pages: R284-R297
- DOI
  10.1152/ajpregu.00725.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] Differential expression of Na+-Clcotransporter and Na+-K+-Clcotransporter2 in the distal nephrons of euryhaline and seawater pufferfishes2011
- Author(s)
  Kato, A., Muro, T., Kimura, Y., Li, S.-S., Islam, Z., Ogoshi, M., Doi, H., Hirose, S
- Journal Title
  
  Am. J. Physiol. Regul. Integr. Comp. Physiol
  
  Volume: 300
- Data Source
  KAKENHI-PROJECT-22657029
[Journal Article] Rh glycoprotein expression is modulated in pufferfish (Takifugu rubripes) during high environmental ammoniaexposure2010
- Author(s)
  Nawata CM, Hirose S, Nakada T, Wood CM, Kato A.
- Journal Title
  
  J Exp Biol.
  
  Volume: 213 Issue: 18 Pages: 3150-3160
- DOI
  10.1242/jeb.044719
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] From blood typing to a transport metabolon2010
- Author(s)
  Hirose, S., Nakada, T.
- Journal Title
  
  Am.J.Physiol.Cell.Physiol.
  
  Volume: 298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22657029
[Journal Article] Rhesus glycoprotein p2(Rhp2) is a novel member of the Rh family of ammonia transporters highly expressed in shark kidney2010
- Author(s)
  Nakada, T., Westhoff, C. M., Yamaguchi, Y., Hyodo, S., Li, X., Muro, T., Kato, A., Nakamura, N., Hirose, S.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 285 Issue: 4 Pages: 2653-2664
- DOI
  10.1074/jbc.m109.052068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570061, KAKENHI-PROJECT-22370029
[Journal Article] Identification of zebrafish Fxyd11aprotein that is highly expressed inion-transporting epithelium of the gilland skin and its possible role in ionhomeostasis2010
- Author(s)
  Saito K, Nakamura N, Ito Y, HoshijimaK, Esaki M, Zhao B, Hirose S
- Journal Title
  
  Front Physiol
  
  Volume: 1:129 Pages: 1-14
- Data Source
  KAKENHI-PROJECT-22657029
[Journal Article] Identification of renal transporters involved in sulfate excretion inmarine teleost fish2009
- Author(s)
  Kato A, Chang MH, Kurita Y, Nakada T, Ogoshi M, Nakazato T, Doi H, Hirose S, Romero MF.
- Journal Title
  
  Am J Physiol RegulIntegr Comp Physiol
  
  Volume: 297 Issue: 6 Pages: R1647-R1659
- DOI
  10.1152/ajpregu.00228.2009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370029
[Journal Article] Neuroblastoma GOTO cells are hypersensitive todisruption of lipid rafts2009
- Author(s)
  Tomioka, R., Minami, N., Kushida, A., Horibe, S., Izumi, I., Kato, A., Fukushima, K., Ideo, H., Yamashita, K., Hirose, S., and Saito, Y.
- Journal Title
  
  Biochem. Biophys. Res. Commun
  
  Volume: 389 Pages: 122-127
- Data Source
  KAKENHI-PROJECT-22657029
[Journal Article] コネキシンのチャネル活性と遺伝子の発現制御-筋原繊維が平行に並ぶ仕組み解明の糸口-2008
- Author(s)
  広瀬茂久
- Journal Title
  
  Transportsome Quarterly Summer2008
  
  Pages: 10-13
- Data Source
  KAKENHI-PROJECT-19657031
[Journal Article] 酸性湖とアルカリ湖にすむ魚の適応戦略2007
- Author(s)
  広瀬茂久他
- Journal Title
  
  極限環境微生物学会誌 5(印刷中)
- NAID
  130004486967
- Data Source
  KAKENHI-PROJECT-18059010
[Journal Article] Expression of endocrine genes in zebrafish larvae in response to environmental salinity2007
- Author(s)
  Hoshijima, K., Hirose, S.
- Journal Title
  
  J. Endocrinol. 193
  
  Pages: 481-491
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2007) Ammonia secretion from fish gill depends on a set of Rh glycoproteins2007
- Author(s)
  Nakada, T., Westhoff, C.M., Kato, A., Hirose, S.
- Journal Title
  
  FASEB J. 21
  
  Pages: 1067-1074
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2007) Pillar cell and erythrocyte localization of fugu ET_A receptor and its implication2007
- Author(s)
  Sultana, N., Nag, K., Kato, A., Hirose, S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 355
  
  Pages: 149-155
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] Expression of endocrine genes in zebrafish larvae in response to environmental salinity2007
- Author(s)
  Hoshijima, K. & Hirose, S.
- Journal Title
  
  J. Endocrinol. 193
  
  Pages: 481-491
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18059010
[Journal Article] Expression of endocrine genes in zebrafish larvae in response to environmental salinity2007
- Author(s)
  Hoshijima, K., Hirose, S.
- Journal Title
  
  J. Endocrinol (印刷中)
- Data Source
  KAKENHI-PROJECT-17657044
[Journal Article] Expression of endocrine genes in zebrafish larae in response to environmental salinity2007
- Author(s)
  Hoshijima, K., Hirose, S.
- Journal Title
  
  J. Endocrinol. (in press)
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2007) Visualization in zebrafish larvae of Na^+ uptake in mitochondria-rich cells whose differentiation is dependent on foxi3a2007
- Author(s)
  Esaki, M., Hoshijima, K., Kobayashi, S., Fukuda, H., Kawakami, K., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 292
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2007) Fluorescence visualization of branchial collagen columns embraced by pillar cells2007
- Author(s)
  Kudo, H., Kato, A., Hirose, S.
- Journal Title
  
  J.Histochem.Cytochem. 55
  
  Pages: 57-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] 酸性湖とアルカリ湖にすむ魚の適応戦略2007
- Author(s)
  広瀬茂久他
- Journal Title
  
  極限環境微生物学会誌 5(印刷中)
- NAID
  130004486967
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2007) Expression of endocrine genes in zebrafish larvae in response to environmental salinity2007
- Author(s)
  Hoshijima, K., Hirose, S.
- Journal Title
  
  J.Endocrinol. 193
  
  Pages: 481-491
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2006) MARCH-III is a novel component of endosomes with properties similar to those of MARCH-II2006
- Author(s)
  Fukuda, H., Nakamura, N., Hirose, S.
- Journal Title
  
  J.Biochem. 139
  
  Pages: 137-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] 水環境で生きるための化学2006
- Author(s)
  広瀬茂久, 中田勉
- Journal Title
  
  化学 61
  
  Pages: 64-65
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2006) Molecular and functional characterization of adrenomedullin receptors in pufferfish2006
- Author(s)
  Nag, K., Kato, A., Nakada, T., Hoshijima, K., Mistry, A.C., Takei, Y., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 290
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] 水環境で生きるための化学2006
- Author(s)
  広瀬茂久, 中田勉
- Journal Title
  
  化学 61
  
  Pages: 64-65
- Data Source
  KAKENHI-PROJECT-18059010
[Journal Article] (2006) MARCH-V is a novel mitofusin 2-and Drp1-binding protein able to change mitochondrial morphology2006
- Author(s)
  Nakamura, N., Kimura, Y., Tokuda, M., Honda, S., Hirose, S.
- Journal Title
  
  EMBO Rep. 7
  
  Pages: 1019-1022
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2006) Role of C-terminus of Kir7.1 potassium channel in cell-surface expression2006
- Author(s)
  Tateno, T., Nakamura, N., Hirata, Y., Hirose, S.
- Journal Title
  
  Cell Biology Internationa 130
  
  Pages: 270-277
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2006) Spliced isoforms of LIM-domain-binding protein (CLIM/NLI/Ldb) lacking LIM-interaction domain2006
- Author(s)
  Tran, Y.H., Xu, Z., Kato, A., Mistry, A.C., Goya, Y., Taira, M., Brandt, S.J., Hirose, S.
- Journal Title
  
  J.Biochem. 140
  
  Pages: 105-119
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) Roles of Slc13a1 and Slc26a1 sulfate transporters of eel kidney in sulfate homeostasis and osmoregulation in freshwater2005
- Author(s)
  Nakada, T., Zandi-Nejad, K., Kurita, Y., Kudo, H., Broumand, V., Kwon, C.Y., Mercado, A., Mount, D.B., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking2005
- Author(s)
  Nakamura, N., Fukuda, H., Kato, A., Hirose, S.
- Journal Title
  
  Mol.Biol.Cell. 16
  
  Pages: 1696-1710
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) Identification, evolution, and regulation of expression of guinea pig trappin with an unusually long transglutaminase substrate domain2005
- Author(s)
  Furutani, Y., Kato, A., Fibriani, A., Hirata, T., Kawai, R., Jeon, J.-H., Fujii, Y., Kim, I.-G., Kojima, S., Hirose, S.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 20204-20215
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) Mutational analysis of action of mitochondrial fusion factor mitofusin-22005
- Author(s)
  Honda, S., Aihara, T., Hontani, M., Okubo, K., Hirose S.
- Journal Title
  
  J.Cell Sci. 118
  
  Pages: 3153-3161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] 塩類細胞の分子生物学「海洋生物の機能--生命は海にどう適応しているか」2005
- Author(s)
  星島一幸, 中田勉, 広瀬茂久
- Journal Title
  
  海洋生命系のダイナミクス第2巻第I部2章
  
  Pages: 36-53
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) A novel type of urea transporter, UT-C, highly expressed in proximal tubule of seawater eel kidney2005
- Author(s)
  Mistry, A.C., Chen, G., Kato, A., Nag, K., Sands, J.M., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 288
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) NHE3 in an ancestral vertebrate : primary sequence, distribution, localization, and function in gills2005
- Author(s)
  Choe, K.P., Kato, A., Hirose, S., Plata, C., Sindic, A., Romero, M.F., Claiborne, J.B., Evans, D.H.
- Journal Title
  
  Am.J.Physiol. 289
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2005) Takifugu obscurus is a euryhaline fugu species very close to Takifugu rubripes and suitable for studying osmoregulation2005
- Author(s)
  Kato, A., Doi, H., Nakada, T., Sakai, H., Hirose, S.
- Journal Title
  
  BMC Physiology 5
  
  Pages: 1-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] pH3.5の湖にすむ魚の秘密2004
- Author(s)
  広瀬茂久
- Journal Title
  
  現代化学 2004
  
  Pages: 28-33
- NAID
  40006159402
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2004) FHL5, a novel actin fiber-binding protein, is highly expressed in gill pillar cells and responds to wall tension in eels2004
- Author(s)
  Mistry, A.C., Kato, A., Tran, Y., Honda, S., Tsukada, T., Takei, Y., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 287
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] Multiple processing of Ig-Hepta, a G protein-coupled receptor with immunoglobulin (Ig)-like repeats.2004
- Author(s)
  Hirose.S.et al.
- Journal Title
  
  J.Pharmacol.Sci. 94
  
  Pages: 66-66
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2003) Molecular biology of major components of chloride cells2003
- Author(s)
  Hirose, S., Kaneko, T., Naito, N., Takei, Y.
- Journal Title
  
  Comparative Biochemistry and Physiology Part B136
  
  Pages: 593-620
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2003) Expression of the K^+ channel Kir7.1 in the developing rat kidney : role in K^+ excretion2003
- Author(s)
  Suzuki, Y., Yasuoka, Y., Shimohama, T., Nishikitani, M., Nakamura, N., Hirose, S., Kawahara, K.
- Journal Title
  
  Kidney Int. 63
  
  Pages: 969-975
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] Molecular biology of major components of chloride cells.2003
- Author(s)
  Hirose, S., et al.
- Journal Title
  
  Comparative Biochemistry and Physiology Part B 136
  
  Pages: 593-620
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2003) Mechanism of acid adaptation of a fish living in a pH 3.5 lake2003
- Author(s)
  Hirata, T., Kaneko, T., Ono, T., Nakazato, T., Furukawa, N., Hasegawa, S., Wakabayashi, S., Shigekawa, M., Chang, M.H., Romero, M., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 284
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] The natriuretic peptide system in eels : a key endocrine system for euryhalinity?2002
- Author(s)
  Takei, Y., Hirose, S.
- Journal Title
  
  Am. J. Physiol. 282 (4)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2002) The natriuretic peptide system in eel : a key endocrine system for euryhalinity?2002
- Author(s)
  Takei, Y., Hirose, S.
- Journal Title
  
  Am.J.Physiol. 282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2002) Cleavage of Ig-Hepta at a "SEA" module and at a conserved G protein-coupled receptor proteolytic site2002
- Author(s)
  Abe, J., Fukuzawa, T., Hirose, S.
- Journal Title
  
  J.Biol.Chem. 277
  
  Pages: 23391-23398
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Journal Article] (2002) RING finger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial cells of Japanese eel, Anguilla japonica2002
- Author(s)
  Miyamoto, K., Nakamura, N., Kashiwagi, M., Honda, S., Kato, A., Hasegawa, S., Takei, Y., Hirose, S.
- Journal Title
  
  Eur.J.Biochem. 269
  
  Pages: 6152-6161
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14104002
[Presentation] ガングリオシドGM2を主成分とするラフトの挙動2012
- Author(s)
  広瀬茂久
- Organizer
  第27回動物細胞工学シンポジウム
- Place of Presentation
  キャンパス・イノベーションセンター,東京
- Year and Date
  2012-06-01
- Data Source
  KAKENHI-PROJECT-22657029
[Presentation] ガングリオシドGM2を主成分とするラフトの挙動2012
- Author(s)
  広瀬茂久
- Organizer
  第27回動物細胞工学シンポジウムキャンパス・イノベーションセンター
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22657029
[Presentation] Interaction of surfactant protein D, which constitutes one of the first lines of innate immune defense, with an orphan GPCR2012
- Author(s)
  Shigehisa Hirose et al.
- Organizer
  IEIIS2012: Homeostatic Inflammation Symposium
- Place of Presentation
  学術総合センター（東京都）
- Year and Date
  2012-10-23
- Data Source
  KAKENHI-PUBLICLY-24117707
[Presentation] A metabolic futile cycle is operating in gas gland cells of fugu swimbladder2011
- Author(s)
  宗像啓司郎,大方香代子,馬場麻人,土井啓行,広瀬茂久,加藤明
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23657054
[Presentation] 海水魚腎臓のCa^<2+>, Mg^<2+>排出を担うイオン輸送体および鰾(うきぶくろ)の酸素ガス充填を担う乳酸輸送体の解析2011
- Author(s)
  加藤明, Islam Zinia,梅澤誉広,御輿真穂,林菜穂子,土井啓行, Min-Hwang Chang, Michael F. Romero,広瀬茂久
- Organizer
  第6回トランスポーター研究会年会
- Place of Presentation
  東北大学(仙台)
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23657054
[Presentation] 海水魚腎臓のCa^<2+>,Mg^<2+>排出を担うイオン輸送体および鰾(うきぶくろ)の酸素ガス充填を担う乳酸輸送体の解析2011
- Author(s)
  加藤明, Islam Zinia, 梅澤誉広, 御輿真穂, 林菜穂子, 土井啓行, Min-Hwang Chang, Michael F.Romero, 広瀬茂久
- Organizer
  第6回トランスポーター研究会年会(JTRA2011)
- Place of Presentation
  仙台
- Year and Date
  2011-06-11
- Data Source
  KAKENHI-PROJECT-23657054
[Presentation] A metabolic futile cycle is operating in gas gland cells of fugu swimbladder2011
- Author(s)
  宗像啓司郎, 大方香代子, 馬場麻人, 土井啓行, 広瀬茂久, 加藤明
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-23657054
[Presentation] Methyl-beta-cyclodextrin-mediatedlipid raft disruption causes acuteapoptosis in neuroblastoma GOTO cell2010
- Author(s)
  Tomioka, R., Kato, A., and Hirose, S
- Organizer
  Keystone Symposia on Molecular and Cellular Biology Molecular Basis for Biological Membrane Organization and Dynamics(A5)
- Place of Presentation
  Snowbird, Utah, USA
- Data Source
  KAKENHI-PROJECT-22657029

1. KATO Akira (40311336)

# of Collaborated Projects: 9 results

# of Collaborated Products: 26 results
2. 岩永貞昭 (90029942)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. HAGIWARA Hiromi (90189465)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. NARUSE Mitsuhide (40120018)

# of Collaborated Projects: 3 results

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39. SAMBHI Mohinder P.

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40. HIMENO Hideo

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42. AKITA Makoto

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59. 兵藤晋

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HIROSE Shigehisa 広瀬 茂久

廣瀬 茂久 ヒロセ シゲヒサ

Research Projects

Research Products

Co-Researchers

肺胞内で異物を捕捉するレクチン様蛋白質ＳＰーＤによる受容体を介した炎症制御機構Principal Investigator

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A metabolic futile cycle is operating in gas gland cells of the swimbladder.Principal Investigator

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Identification of novel gastric systems by comparing genomic sequences between stomachless fishes and true stomach fishes

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Identification of oxygen gas channels involved in gas secretion into the swimbladder

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Identification of transporters involved in excretion of toxic sulfate and borate by seawater fishPrincipal Investigator

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Visualization and characterization of GM2-rich lipid raft microdomainPrincipal Investigator

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新発見の粘度センサーの作用機構Principal Investigator

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初期の筋繊維形成の足場となる配向決定因子の同定Principal Investigator

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ゼブラフィッシュのイオン輸送系変異体を用いたトランスポートソームの解析Principal Investigator

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新発見の多価ホルモン受容体の構造と機能及び生理学的意義Principal Investigator

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新規プロセッシング酵素の探索Principal Investigator

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Molecular characterization of chloride cells and their mechanism of differentiationPrincipal Investigator

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新発見の接着型プロテアーゼインヒビターとがん細胞の浸潤・転移Principal Investigator

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HIROSE Shigehisa 広瀬茂久

廣瀬茂久ヒロセシゲヒサ