AKIYAMA Shinichi 秋山伸一

Researcher Number	60117413
External Links
Affiliation (based on the past Project Information) *help	2012: 徳島大学, ヘルスバイオサイエンス研究部, 客員教授 2012: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 客員教授 2010 – 2011: 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任教授 2007 – 2009: Kagoshima University, 大学院・医歯学総合研究科, 教授 2005 – 2006: 鹿児島大学, 大学院医歯学総合研究科, 教授 … More 2003 – 2005: 鹿児島大学, 大学院・医歯学総合研究科, 教授 1986 – 2002: 鹿児島大学, 医学部, 教授 1999: Kagoshima University, Faculty of Medicine, Professor, 医学部・腫瘍研究施設, 教授 1986: 大分医科大学, 助教授 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / Pathological medical chemistry / Biological Sciences / Clinical oncology / 血管生物学 / General medical chemistry Except Principal Investigator General surgery / Pathological medical chemistry / Neurology / Digestive surgery / Experimental pathology
Keywords	Principal Investigator MRP / チミジンホスホリラーゼ / 多剤耐性 / 血管新生 / GS-X pump / アポトーシス / TPI / 2-deoxy-L-ribose / 2-deoxy-D-ribose / PD-ECGF … More / シスプラチン耐性 / 耐性克服 / Thymidine phosphorylase / 転移 / GSH / signature sequence / MRP1 / mitochondria / arsenite / cisplatin / resistance / ABCB6 / cMOAT / ATL / Cisplatin-resistance / デオキシリボース / フォトアフィニティーラベル法 / Akt / PI3K / TP / ROS / IL-8 / thymidine phosphorylase / ノックアウトマウス / angiogenesis / metastasis / Apoptosis / 低酸素 / 肺扁平上皮癌 / PAK-104P / ロイコトリエンC_4 / 不定型多剤耐性 / ABCトランスポータ / ABCトランスポーター / シスプラチン / 耐性 / ヒ素 / apotosis / hypoxia / 2-depxy-D-ribose / チミジン / PDーECGF / チトクロームC / アトポーシス / PAK-104p / TCC / Squamous cell carcinoma / 移行上皮癌 / Leukotriene C4 / GS-Xポンプ / ロイコトリエンC4 / 重金属 / GS-X ポンプ / Prognosis / Metastasis / Thrombomodulin / Colorectal carcinoma / Deoxyribose / Angiogenic factor / Thymidine Phosphorylase / 予後 / トロンボモジュリン / 大腸癌 / 血管新生因子 / Reversal of multidrug resistance / PAK-200 / dihydropyridine analogue / Cisplatin resistance / Adriamycin resistance / Atypical multidrug-resistant mutants / アドリアマイシン耐性 / PAKー200 / 多剤耐性克服 / ジヒドロピリジン誘導体 / 温度感受性変異株 / 細胞内取り込み過程 / エンドサイトーシス / トランスフェリン / 上皮生長因子 / 解糖系 / pentose phosphate pathway / NADPH oxidase / NFkB / NADPH / ペントースリン酸経路 / 解糖経路 / 分子標的治療 / ストレス / P38 / PTEN / ARK / 高浸透圧 / osmotic stress / LRP / Vault / MVP / survivin / Arsenite / p38 / MMP-9 / fibroblast / c-myc / EGR1 / TSP1 / 5FU / apoptosis / drug resistance / thymdine phosphorylase / 線維芽細胞 / マイクロDNA / 5-Fu / BNIP3 / HIF-1 / IkB / β / IKKα / NF-κB / 血管新生阻害効果 / GBL / NADPHオキシダーゼTegafur / Thymidine phosphorylase (TP) / 5-FU / TSP-1 / NFκB / 2-デオキシ-L-リボース / 2-デオキシ-D-リボース / 腫瘍増殖 / invasion / Thymidine_phosphorylase / HIF-1α / BN1P3 / 浸潤 / BSO / P-糖蛋白質 / トポイソメラーゼII / 細胞膜蛋白質 / シスプラチンの排出ポンプ / シスプラチンの蓄積 / ヒト癌KB細胞 / PAKー104P / セファランチン / 副腎 / 薬剤結合部位 / Pー糖蛋白質 … More Except Principal Investigator チミジンホスホリラーゼ / 血管新生 / アポトーシス / DNAトポイソメラーゼ / 多剤耐性 / 耐性克服 / MRP / 抗がん剤耐性 / シスプラチン耐性 / TSP / HAM / HTLV-I / VEGF-D / VEGF-C / ROS / IL8 / TNFa / thymidine phosphorylase / metastasis / 微小転移 / 血管新生因子 / P53 / 塞栓療法 / 選択毒性 / がん化学療法 / p-糖蛋白 / P-糖蛋白 / 耐性獲得 / alpha-Interferon / Polyarthritis / Retrovirus / Spastic Paraparesis / HTLV-I-Associated / HILV-I associated Myelopathy / レトロウィルス / ハム / ATL / HTLV-I脊髄症 / 成人T細胞白血病 / HTLV-I関連疾患 / lymph node micrometastasis / mucin / thymidine phospholyrase / invasion and metastasis / pancreatic cancer / 免疫組織化学 / MUC1 / 浸潤-転移 / リンパ節郭清 / リンパ節微小転移 / ムチン / 浸潤・転移 / 膵癌 / roxithromicin / hepatocarcinogenesis / 1L-8 / TNF-a / IL-6 / IL6 / Roxithromycin / TNF / 肝細胞癌 / 活性酸素 / ロキシスロマイシン / IL-8 / 肝発癌 / knock-out mouse / hypoxia / apoptosis / angipgenesis / 2deoxy-I-ribose / 2deoxy-D-ribose / 白質脳症 / MNGIE / ノックアウトマウス / 2デオキシLリボース / 2デオキシDリボース / IL-1a / adhesion molecule / micrometastasis / angiogenesis / invasion / carcinoma of digestive organs / クッパー細胞 / E-カドヘリン・カテニン / 肝転移 / 基底膜浸潤 / ヌードマウス / PCR / アンチセンス / カドヘリン-カテニン / Eーカドへリン / 内皮細胞 / 細胞間相互作用 / E-カドヘリン / IL-1α / 接着因子 / 転移 / 浸潤 / 消化器癌 / Lectin SNA / DF3 antigen / neck metastasis / benign HPV / malignant HPV / Blinkman index / laryngeal cancer / female patient / p53 / HPV / EBV / レクチン組織化学 / 声門上部癌 / 中国潘陽 / 乳腺型アポムチン関連抗原 / T抗原 / 頸部リンパ節転移 / 喫煙 / HPV型 / 女性喉頭癌 / 中国瀋陽 / Chemtaxis / Chick embryo chorioallantoic membrane assay / The sensitivity to anti-tumor drugs / Angiogenesis / Tymidine phosphorylase / 鶏卵漿尿膜法 / 遊走 / 鶏卵しょう尿膜法 / 抗がん剤感受性 / マイクロカプセル / 効果増強 / がん転移モデル / 抗がん剤効果増強 / 多剤耐性ヒト癌KB変異株 / DHFR遺伝子 / セファランチン / ダイハイドロピリジン誘導体 / 抗腫瘍性プロスタグランジン / チロジンキナーゼ癌遺伝子群 / アンサマイシン系ハービマイシン / ブレオマイシン不活化酵素 / フルオロウリジン / 低酸素 / 細胞周期 / 細胞接着 / 化学発癌 / 癌治療 / ゲノム医学 / 構造生物学 / シグナル伝達 / ウイルス発癌 / 海外派遣 / 国際学術 / グルタチオン / ABCスーパーファミリー / オンコプロテイン-18 / DNAメチル化 / 抗癌剤感受性 / ABCトランスポーター・スーパーファミリー / 細胞内分子標的 / トポイソメラーゼII / CMOAT / MRPファミリー蛋白 / P-糖蛋白質 / MDRI 遺伝子 / グルタチオン抱合体ポンプ / ポンプ / 抗癌剤 / イオン / 膜輸送体 / トランスポータ / 心臓 / 脳 / 糖尿病 / 電気生理学 / 分子生物学 / トランスポーター / チャネル / ATP / ABCカッセトファミリー / 薬剤耐性 / 抗がん剤 / MDRI / 5-フルオロウラシル耐性 / 耐性マーカー / 5ーフルオロウラシル耐性 / グルタチオン・チオ-ル・トランスフェラ-ゼ / メタロチオネイン / DNAトポイソメラ-ゼ / Pー糖蛋白 / 多剤耐性遺伝子 Less

Molecular basis for thefunctions of thymidine phosphorylase and preclinical study of an inhibitor of thymidine phosphorylase , TPIPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  The University of Tokushima
Analysis of physiological function of vaultsPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Shinichi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
Molecular targeting agents that suppress invasion and metastasis of cancer cellsPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Shinichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
Search and analysis of genes involved in the sensitivity to arsenic trioxide of human cells.Principal Investigator
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
Fundamental research on identification and its control of the priming factor in liver cancer proliferation
- Principal Investigator
  
  UENO Shinichi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Kagoshima University
The analysis of thymidine phospholyrase and mucin expression related to invasion and metastasis in pancreas cancer
- Principal Investigator
  
  NATSUGOE Shoji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Kagoshima University
腫瘍増殖・浸潤・転移を抑制する新規薬剤の開発Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kagoshima University
Analysis of the mechanisms for biological activities of thymidine phosphorylase
- Principal Investigator
  
  FURUKAWA Tatsuhiko
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
チミジンホスホリラーゼのがん血管新生とアポトーシスへの関与Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kagoshima University
Physiological function of thymidine phosphorylase and the involvement of the enzyme in tumor growthPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Shinichi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
アメリカ大陸を中心としたがん研究先進グループとの研究交流
- Principal Investigator
  
  山本雅
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
チミジンホスホリラーゼ阻害剤による腫瘍増殖抑制とその基礎的研究
- Principal Investigator
  
  古川龍彦
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University
抗がん剤感受性を制御する細胞内分子標的の発現と機能
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
Analysis of structure and function of GS-X pumps.Principal Investigator
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
Studies on identification of factors associated with invasion and metastasis of cancer cells and their interaction with stromal cells in carcinoma of the digestive organs
- Principal Investigator
  
  TAKAO Sonshin
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General surgery
- Research Institution
  Kagoshima University
臨床応用可能な抗がん剤耐性マーカーの探索とその克服
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
MRPの機能と臨床での多剤耐性の関与およびその克服Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University
ATP駆動型トランスポータとチャネルの構造・機能協関
- Principal Investigator
  
  植田和光
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
MRPの薬剤輸送機能とイオンチャネル活性の解折
- Principal Investigator
  
  古川龍彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University
Clinical epidemiology of female laryngeal cancer in China. -with a special attention to clinicopathological, cytochemical and molecular biological studies.-
- Principal Investigator
  
  OHYAMA Masaru
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
臨床応用可能な抗がん剤耐性マーカーの探索とその克服
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
P-糖蛋白質の関与しない多剤耐性の機構と、その克服方法の開発Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kagoshima University
The effects of Thymidine phsphorylase on tumor angiogenesis and on the sensitivity to anti-tumor drugs
- Principal Investigator
  
  HARAGUCHI Misako
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
Structure and function of an active efflux pump for cisplatinPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Shinichi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
臨床応用可能な抗がん剤耐性マーカーの探索とその克服
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
チミジンホスホリラーゼ活性と血管新生の関連性についてPrincipal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  血管生物学
- Research Institution
  Kagoshima University
The mechanism of angiogenesis by PD-ECGFPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
シスプラチン耐性機構の解析と耐性克服方法の開発Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
Pー糖蛋白質の関与しない多剤耐性の分子機構の解明と克服方法の開発Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
新しい制がん剤耐性遺伝子群の解析と克服法の確立
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  大分医科大学
Pー糖蛋白質の構造と機能の研究Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kagoshima University
Isolation and analysis of atypical multidrug-resistant mutants.Principal Investigator
- Principal Investigator
  
  AKIYAMA Shin-ichi
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kagoshima University
多剤耐性遺伝子の発現と耐性腫瘍出現の関連性、およびP-糖蛋白質の機能の解析Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
Research on pathogenesis, epidemiology and treatment for HTLV-I related neurological disorders
- Principal Investigator
  
  IGATA Akihiro
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Neurology
- Research Institution
  Kagoshima University
フォトアフィニティーラベル法を用いた耐性克服薬剤の検索と耐性機構の解析Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kagoshima University
上皮生長因子とトランスフェリンの細胞内取り込み過程欠損変異株の分離と解析Principal Investigator
- Principal Investigator
  
  秋山伸一
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kagoshima University
腫瘍細胞の薬剤低感受性機構の解析とその克服に関する研究
- Principal Investigator
  
  山田一正
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Nagoya University
腫瘍増殖部位よりみた抗がん剤の選択毒性の向上
- Principal Investigator
  
  塚越茂
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
腫瘍増殖部位よりみた抗がん剤の選択毒性の向上
- Principal Investigator
  
  塚越茂
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research

All 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] がん薬物療法学増刊号2009
- Author(s)
  秋山伸一
- Total Pages
  5
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-19590314
[Book] がん薬物療法学増刊号2009
- Author(s)
  秋山伸一
- Total Pages
  5
- Publisher
  日本臨床
- Data Source
  KAKENHI-PROJECT-17016058
[Book] 日本臨床がん薬物療法学(増刊号)2009
- Author(s)
  秋山伸一
- Data Source
  KAKENHI-PROJECT-19590314
[Book] 消化器がん化学療法2008
- Author(s)
  秋山伸一
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-19590314
[Book] 消化器がん化学療法2008(共著)2008
- Author(s)
  秋山伸一
- Total Pages
  7
- Publisher
  株式会社日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-17016058
[Book] 消化器がん化学療法2008(共著)2008
- Author(s)
  秋山伸一
- Total Pages
  7
- Publisher
  株式会社日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-19590314
[Book] 消化器がん化学療法20082008
- Author(s)
  秋山伸一
- Total Pages
  7
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-17016058
[Book] 消化器がん化学療法20082008
- Author(s)
  秋山伸一
- Total Pages
  7
- Publisher
  日本メディカルセンター
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Macrophage stimulating protein promotes liver metastases of small cell lung cancer cells by affecting the organ microenvironme2013
- Author(s)
  Sato S, Hanibuchi M, Kuramoto T, Yamamori N, Goto H, Ogawa H, Mitsuhashi A, Van TT, Kakiuchi S, Akiyama SI, Nishioka Y, Sone S
- Journal Title
  
  Clin Exp Metastasis
  
  Volume: 30 Issue: 3 Pages: 333-344
- DOI
  10.1007/s10585-012-9540-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-22501048, KAKENHI-PROJECT-24390210
[Journal Article] Akiyama S, Thymidine phosphorylase enhances reactive oxygen species generation and interleukin-8 expression in human cancer cells2012
- Author(s)
  Tabata S, Ikeda R, Yamamoto M, Furukawa T, Kuramoto T, Takeda Y, Yamada K, Haraguchi M, Nishioka Y, Sone S
- Journal Title
  
  Oncol Rep
  
  Volume: 28 Pages: 895-902
- DOI
  10.3892/or.2012.1887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-22501047, KAKENHI-PROJECT-22501048, KAKENHI-PROJECT-22510236, KAKENHI-PROJECT-22590287, KAKENHI-PROJECT-24390210
[Journal Article] チミジン代謝とがん2012
- Author(s)
  田畑祥、秋山伸一
- Journal Title
  
  実験医学
  
  Volume: Vol.30、No.15 Pages: 87-93
- Data Source
  KAKENHI-PROJECT-22501048
[Journal Article] Dll4-Fc, an inhibitor of Dll4-Notch signaling, suppresses liver metastasis of small cell lung cancer cells through the downregulation of the NF-kappa-B activity.2012
- Author(s)
  Kuramoto T, Goto H, Mitsuhashi A, Tabata S, Ogawa H, Uehara H, Sijo A, Kakiuchi S, Maekawa, Yasutomo K, Hanibuchi M, Akiyama SI, Sone S, Nishioka Y
- Journal Title
  
  Mol Cancer Ther
  
  Volume: 11 Issue: 12 Pages: 2578-2587
- DOI
  10.1158/1535-7163.mct-12-0640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20679005, KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-22501048, KAKENHI-PROJECT-24390210, KAKENHI-PROJECT-24590585
[Journal Article] a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model2012
- Author(s)
  Van TT, Hanibuchi M, Goto H, Kuramoto T, Yukishige S, Kakiuchi S, Sato S, Sakaguchi S, Dat LT, Nishioka Y, Akiyama SI, Sone S, SU666
- Journal Title
  
  Respirology
  
  Volume: 17 Issue: 6 Pages: 984-990
- DOI
  10.1111/j.1440-1843.2012.02193.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-22501048, KAKENHI-PROJECT-24390210
[Journal Article] The therapeutic efficacy of S-1 against orthotopically implanted human pleural mesothelioma cells in severe combined immunodeficient mice2011
- Author(s)
  Van TT, Hanibuchi M, Kakiuchi S, Sato S, Kuramoto T, Goto H, Mitsuhashi A, Nishioka Y, Akiyama S, Sone S
- Journal Title
  
  Cancer Chemother Pharmacol
  
  Volume: 68 Issue: 2 Pages: 497-504
- DOI
  10.1007/s00280-010-1503-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390166, KAKENHI-PROJECT-22501048
[Journal Article] 2-Aminophenoxazine-3-one induces cellular apoptosis by causing rapid intracelluar acidification and generating reactive oxygen species in human lung adenocarcinoma cells.2010
- Author(s)
  Chun-Lei Zheng, Xiao-Fang Che, Shin-ichi Akiyama, Akio Tomoda, (他1名3番目)
- Journal Title
  
  Int. J. Oncol. 36
  
  Pages: 641-650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Sensitization of ABCB1 overexpressing cells to chemoterapeutic agents by FG020326 via binding to ABCB1 and inhibiting its function.2009
- Author(s)
  Chun-Iing Dai, Shin-ichi Akiyama, Zhe-sheng Chen, Li-wu Fu., (他9名10番目)
- Journal Title
  
  Biochem. Pharmacol. 78
  
  Pages: 355-364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Cepharanthine is a potent reversal agent for MRP7 (ABGG10)-mediated multidrug resistance.2009
- Author(s)
  Ying Zhou, Tatsuhiko Furukawa, Shin-ichi Akiyama, Zhe-Sheng Chen, (他9名8番目)
- Journal Title
  
  Biochem. Pharmacol. 77
  
  Pages: 993-1001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Thymidine phosphorylase inhibits the expression of proapoptic protein BNIP3. Biochem.2008
- Author(s)
  Ryuji Ikeda, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shin-ichi Akiyama, Katsushi Yamada, (他11名15番目)
- Journal Title
  
  Biophys. Res. Commun. 370
  
  Pages: 220-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives.2008
- Author(s)
  Xiao-Fang Che, Shin-ichi Akiyama, Akio Tomoda.
- Journal Title
  
  Oncol. Rep. 19
  
  Pages: 1253-1258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Hyperosmotic Stress Up-regulates the Expression of Major Vault Protein in SW620 Human Colon Cancer Cells. Exp2008
- Author(s)
  Ikeda R, Che X-F, Akiyama S(他16名)
- Journal Title
  
  Cell Res 314
  
  Pages: 3017-3026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Anti-angiogenic effect of 5-Fluorouracil-based drugs against human colon cancer xenografts2008
- Author(s)
  Ooyama A, Akiyama S(他4人)
- Journal Title
  
  Cancer Lett 267
  
  Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system2008
- Author(s)
  Nakagawa H, Akiyama S(他11人)
- Journal Title
  
  Cancer lett 270(2)
  
  Pages: 295-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one2008
- Author(s)
  Shirato K, Che X-F, Akiyama S(他5人)
- Journal Title
  
  Biol Pharm Bull 31
  
  Pages: 62-67
- NAID
  110006569975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Alterations in the glycoform of cisplatin-resistant human carcinoma cells are caused by defects in the endoplasmic reticulum-associated degradation system.2008
- Author(s)
  Hiroaki Nakagawa, Shin-ichi Akiyama, Shin-ichiro Nishimura., (他10名番11目)
- Journal Title
  
  Cancer Lett. 270
  
  Pages: 295-301
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Copper Transport Systems are Involved in Multidrug Resistance and Drug Transport2008
- Author(s)
  Furukawa T, Akiyama S(他3名)
- Journal Title
  
  Curr Med Chem 15
  
  Pages: 3268-3278
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU2008
- Author(s)
  Zhao H-Y, Che X-F, Akiyama S(他12名)
- Journal Title
  
  Cancer Res 68
  
  Pages: 7035-7041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Apoptosis induction preceded by mitochondrial depolarization in multiple myeloma cell line U266 by 2-aminophenoxazine-3-one.2008
- Author(s)
  Ken Shirato, Shin-ichi Akiyama, Akio Tomoda:, (他5名7番目)
- Journal Title
  
  Biol. Pharm. Bull. 31
  
  Pages: 62-67
- NAID
  110006569975
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Suppression of the proliferation of cancer cell lines, KB-3-1 and K562 cells preceded by a decrease in intracellular pH caused by phenoxazine derivatives2008
- Author(s)
  Che X-F, Akiyama S, Tomoda A
- Journal Title
  
  Oncol Rep 19
  
  Pages: 1253-1258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Anti-angiogenic effect of 5-fluorouracil-based drugs against human colon cancer xenografts.2008
- Author(s)
  Akio Ooyama, Masatatsu Yamamoto, Shin-ichi Akiyama, Masakazu Fukushima, (他2名5番目)
- Journal Title
  
  Cancer Lett. 267
  
  Pages: 26-36
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells.2008
- Author(s)
  Hong-Ye Zhao, Masatatsu Yamamoto, Tatsuhiko Furukawa, Michihiko Kuwano, Shin-ichi Akiyama, (他10名15番目)
- Journal Title
  
  Cancer Lett. 270
  
  Pages: 156-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Hyperosmotic stress up-regulates the expression of major vault protein in SW620 human colon cancer cells.2008
- Author(s)
  Ryuji Ikeda, Tatsuhiko Furukawa, Masatatsu Yamamoto, Katsushi Yamada, Shin-ichi Akiyama., (他14名19番目)
- Journal Title
  
  Exp. Cell Res. 314
  
  Pages: 3017-3026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU.2008
- Author(s)
  Hong-Ye Zhao, Masatatsu Yamamoto, Tatsuhiko Furukawa, Michihiko Kuwano, Shin-ichi Akiyama, (他10名15番目)
- Journal Title
  
  Cancer Res. 68
  
  Pages: 7035-7041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in KM12C cells2008
- Author(s)
  Zhao H-Y, Che X-F, Akiyama S(他12名)
- Journal Title
  
  Cancer Lett. 270
  
  Pages: 156-163
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Thymidine phosphorylase inhibits the expression of proapoptic protein BNIP32008
- Author(s)
  Ikeda R, Che X-F, Akiyama S(他13名)
- Journal Title
  
  Biochem Biophys Res Commun 370
  
  Pages: 220-224
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Reversal of P-Glycoprotein-Mediated Multidrug Resistance by Sipholane Triterpenoids2007
- Author(s)
  Jain S, Akiyama S(他6人)
- Journal Title
  
  J. Nat. Prod 70
  
  Pages: 928-931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells2007
- Author(s)
  Tachiwada T, Che X-F, Akiyama S(他10人)
- Journal Title
  
  Oncol Rep 18
  
  Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] ABCB6 Localizes toboth the outer mutocondrial membrane and the plasma membrane2007
- Author(s)
  Jill K. Paterson, Akiyama S(他11人)
- Journal Title
  
  Biochemistry 33
  
  Pages: 9443-9452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Involvement of Mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3 : microcystin-lr induces the apoptosis via mapk2007
- Author(s)
  Komatsu M, Akiyama S(他6人)
- Journal Title
  
  Toxicol. Sci 97
  
  Pages: 407-416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Reversal effect of BM-cyclin 1 on multidrug resistance in C-A120 cells2007
- Author(s)
  Wang L, Akiyama S(他4人)
- Journal Title
  
  Anti-cancer Drug 18
  
  Pages: 1015-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Copper-Transporting P-Type ATPase, ATP7A, Confers Multidrug Resistance and Its Expression Is Related to Resistance to SN-38 in Clinical Colon Cancer2007
- Author(s)
  Owatari S, Che X-F, Akiyama S(他12人中)
- Journal Title
  
  Cancer Res 67
  
  Pages: 4860-4868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Journal Article] Reversal of P-glycoprotein-mediated multidrug resistance by sipholane triterpenoids.2007
- Author(s)
  Sandeep Jain, Shin-ichi Akiyama, Zhe-Sheng Chen, Khalid A. El Sayed., (他5名5番目)
- Journal Title
  
  J. Nat. Prod. 70
  
  Pages: 928-931
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Copper-Transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer.2007
- Author(s)
  Saruski Owatari, Masatatsu Yamamoto, Shin-ichi Akiyama, Tatsuhiko Furukawa, (他11名14番目)
- Journal Title
  
  Cancer Res. 67
  
  Pages: 4860-4868
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Isolation and characterization of arsenite-resistant human epidermoid carcinoma KB cells.2007
- Author(s)
  Tokushi Tachiwada, Tatsuhiko Furukawa, Masatatsu Yamamoto, Masayuki Nakagawa, Shin-ichi Akiyama:, (他8名13番目)
- Journal Title
  
  Oncol. Rep. 8
  
  Pages: 721-727
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Reversal effect of BM-cyclin1 on multidrug resistance in C-A120 cells.2007
- Author(s)
  Lin Wang, Zhe-Shen Chen, Shin-ichi Akiyama, Li-Jian Xian:, (他2名5番目)
- Journal Title
  
  Anticancer Drug 18
  
  Pages: 1015-1021
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Involvement of mitogen-activated protein kinase signaling pathways in microcystin-LR-induced apoptosis after its selective uptake mediated by OATP1B1 and OATP1B3.2007
- Author(s)
  Masaharu Komatsu, Tatsuhiko Furukawa, Shin-ichi Akiyama, Toru Takeuchi., (他5名7番目)
- Journal Title
  
  Toxicol. Sci. 97
  
  Pages: 407-416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] ABCB6 localizes to both the outer mitochondrial membrane and the plasma membrane.2007
- Author(s)
  Jill K. Paterson, Shin-ichi Akiyama, Michael M Gottesman:, (他10名12番目)
- Journal Title
  
  Biochemistry 33
  
  Pages: 9443-9452
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity.2006
- Author(s)
  Kengo Tsuneyoshi, Tatsuhiko Furukawa, Shin-ichi Akiyama, Masayuki Nakagawa., (他6名9番目)
- Journal Title
  
  Cancer Lett. 244
  
  Pages: 239-246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Anticancer effects of phenoxazine derivatives combined with tumor necrosis factor-related apoptosis-inducing ligand on pancreatic cancer cell lines, KLM-1 and MIA-PaCa-22006
- Author(s)
  Seiko Kato, Shin-ichi Akiyama, Akihisa Abe, Akio Tomoda., (他6名8番目)
- Journal Title
  
  Oncol Rep. 15
  
  Pages: 843-848
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Apolipoprotein E regulates primary cultured human mesangial cell proliferation.2006
- Author(s)
  Yixiang Zhang, Shin-ichi Akiyama, Hiroto Tsubouchi:, (他8名10番目)
- Journal Title
  
  Nephron Exp. Nephrol. 102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Direct activation of the human major vault protein gene by DNA-damaging agents.2006
- Author(s)
  Yuichi Shimamoto, Tatsuhiko Furukawa, Ryuzo Sakata, Shin-ichi Akiyama:, (他4名8番目)
- Journal Title
  
  Oncol Rep. 15
  
  Pages: 645-652
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Protection against DNA damage-induced apoptosis by the angiogenic factor thymidine phosphorylase.2006
- Author(s)
  Hei-Cheul Jeung, Tatsuhiko Furukawa, Shin-ichi Akiyama., (他10名13番目)
- Journal Title
  
  FEBS Lett. 580
  
  Pages: 1294-1302
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] A functional role of intracellular loops of human multidrug resistance protein 1.2006
- Author(s)
  Xiao-Qin Ren, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shin-ichi Akiyama:, (他3名7番目)
- Journal Title
  
  J. Biochem (Tokyo) 140
  
  Pages: 313-318
- NAID
  10018841960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] 2-Deoxy-D-ribose inhibits hypoxiainduced apoptosis by suppressing the phosphorylation of p38 MAPK. Biochem.2006
- Author(s)
  Ryuji Ikeda, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shin-ichi Akiyama:, (他10名14番目)
- Journal Title
  
  Biophys. Res. Commun. 342
  
  Pages: 280-285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] 2-Deoxy-L-ribose inhibits the invasion of thymidine phosphorylaseoverexpressing tumors by suppressing matrix metalloprotease-9.2006
- Author(s)
  Yuichi Nakajima, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shin-ichi Akiyama., (他3名7番目)
- Journal Title
  
  Int. J. Cacncer 119
  
  Pages: 1710-1716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines.2006
- Author(s)
  Xiao-Fang Che, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shin-ichi Akiyama., (他8名12番目)
- Journal Title
  
  Blood 15
  
  Pages: 4880-4887
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] p73 and MDM2 confer the resistance of epidermoid carcinoma to cisplatin by blocking p53.2006
- Author(s)
  Syunji Hayashi, Shin-ichi Akiyama, Akira Nakagawara., (他4名6番目)
- Journal Title
  
  Biochem. Biophys. Res. Commun. 347
  
  Pages: 60-66
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Molecular basis for the involvement of thymidine phosphorylase in cancer invasion.2006
- Author(s)
  Takenari Gotanda, Tatsuhiko Furukawa, Shin-ichi Akiyama, Masayuki Nakagawa., (他10名13番目)
- Journal Title
  
  Int. J. Mol. Med. 17
  
  Pages: 1085-1091
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] GSH suppresses a tryptic site in the C-terminal half of human MRP1.2005
- Author(s)
  Xiao-Qin Ren, Tatsuhiko Furukawa, Shin-ichi Akiyama., (他7名10番目)
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 6231-6237
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] MRP1 mutated in the L0 region transports SN-38 but not leukotriene C4 or estradiol-17 (β-D-glucuronate).2005
- Author(s)
  Tomohiro Noguchi, Shin-ichi Akiyama, Tatsuhiko Furukawa., (他14名16番目)
- Journal Title
  
  Biochem. Pharmacol. 70
  
  Pages: 1056-1065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Cepharanthine potently enhances the sensitivity of anticancer Agents in K562 cells2005
- Author(s)
  Ikeda, R., Che, X-F, Yamaguchi, T., Ushiyama, M., Zeng, C-L., Okumura, H., Takeda, Y, Shibayama, Y, Nakamura, K., Jeung, H-C., Furukawa, T., Sumizawa, T., Haraguchi, M., Akiyama.S., Yamada K.
- Journal Title
  
  Cancer Sci 96
  
  Pages: 327-376
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells.2005
- Author(s)
  Ryuji Ikeda, Tatsuhiko Furukawa, Shin-ichi Akiyama, Katsushi Yamada:, (他11名14番目)
- Journal Title
  
  Cancer Sci. 96
  
  Pages: 327-376
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] GSH suppresses a tryptic site in the C-terminal half of human MRP1.2005
- Author(s)
  Ren, X-Q., Furukawa, T., Nakajima, Y, Takahasi, Aoki, H., Sumizawa, T., Haraguchi, M., Kobayashi, M., Chijiwa, K., Akiyama, S.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 6231-6237
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] 2-Amino-phenoxazine-3-one attenuates glucose-induced augmentation of embryonic form of myosin heavy chain, endothelin-1 and plasminogen activator inhibitor-1 in human umbilical vein endothelial cells.2005
- Author(s)
  Gen Fukuda, Shin-ichi Akiyama, Subrata Chakarabarti, Masato Oodawara., (他6名7番目)
- Journal Title
  
  Biol. Pharm Bull. 28
  
  Pages: 797-801
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Thymidine phosphorylase suppresses apoptosis induced by microtubuleinterfering agents.2005
- Author(s)
  Hei-Cheul Jueng, Tatsuhiko Furukawa, Shin-ichi Akiyama., (他6名9番目)
- Journal Title
  
  Biochem. Pharmacol. 70
  
  Pages: 13-21
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] The role of thymidine phosphorylase, an angiogenic enzyme, in tumor progression2004
- Author(s)
  Akiyama, S.
- Journal Title
  
  Cancer Sci. 95
  
  Pages: 851-857
- NAID
  10014197551
- Data Source
  KAKENHI-PROJECT-12217121
[Journal Article] Function of the ABC signature sequences in the human multidrug resistance protein 1.2004
- Author(s)
  Ren, X.-Q., Furukawa, T., Haraguchi, M., Sumizawa, T., Aoki, S., Kobayashi, M., Akiyama, S.
- Journal Title
  
  Mol.Pharmacol. 65
  
  Pages: 1536-1542
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] Characterization of MVP and VPARP assembly into vault ribonucleoprotein complexes.2004
- Author(s)
  Zheng, C-L., Sumizawa, T., Che, X-F, Tsuyama, S., Furukawa, T., Haraguchi, M., Gao, H., Gotanda, T., Jueng, H-Cl., Murata, F., Akiyama, S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 326
  
  Pages: 100-107
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] Inhibition of Metastasis of tumor cells overexpressing theymidine phosphorylase by 2-Deoxy-L-ribose.2004
- Author(s)
  Nakajima, Y., Gotanda, T., Uchimiya, H., Furukawa, T., Haraguchi, M., Ikeda, R., Sumizawa, T., Yoshida, H., Akiyama, S.
- Journal Title
  
  Cancer Res. 64
  
  Pages: 1749-1801
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors.2003
- Author(s)
  Wang, X., Furukawa, T., Nitanda, T., Okamoto, M., Sugimoto, Y., Akiyama, S., Baba, M.
- Journal Title
  
  Mol.Pharmacol. 63
  
  Pages: 65-72
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] Localization of the GSH-dependent photolabelling site of an agosterol A analog on human MRP1.2003
- Author(s)
  Ren, X.-Q., Furukawa, T., Aoki, S., Sumizawa, T., Haraguchi, M., Che, X-F., Kobayashi, M., Akiyama, S.
- Journal Title
  
  Br.J.Pharmacol. 138
  
  Pages: 1553-1561
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] Thymidine phosphorylase inhibits apoptosis induced by cisplatin.2003
- Author(s)
  Ikeda, R., Furukawa, T., Mitsuo, R., Noguchi, T., Kitazono, M., Okumura, H., Sumizawa, T., Haraguchi, M., Che, X-F, Uchimiya, H., Nakajima, Y., Ren, X-Q., Oiso, S., Inoue, I., Yamada, K., Akiyama, S.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 301
  
  Pages: 358-363
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-flurouracil in human carcinoma cells.
- Author(s)
  Shigeto Matushita, Tatsuhiko Furukawa, Masatatsu Yamamoto, Shin-ichi Akiyama., (他13名17番目)
- Journal Title
  
  Int. J. Oncol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Major vault protein forms complexes with hypoxia-inducible factor (HIF)-1・and reducesHIF-1・・level in ACHN human renal adenocarcinoma cells.
- Author(s)
  Ken-ichi Iwashita, Tatsuhiko Furukawa, Shin-ichi Akiyama, Katsushi Yamada., (他4名7番目)
- Journal Title
  
  Cancer Sci. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016058
[Journal Article] Thymidine phosphorylase suppresses apoptosis induced by Microtubule-interfering agents.
- Author(s)
  Jeung, H-C., Che, X-F, Haraguchi, M., Furukawa, T., Zeng, C-L., Sumizawa, T., Rha, S-Y, Akiyama, S.
- Journal Title
  
  Biochemical Pharmacol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590277
[Journal Article] A Novel targeting therapy of malignant mesothelioma using anti- podoplanin antibody
- Author(s)
  Abe S, Morita Y, Kaneko MK, Hanibuchi M, Tsujimoto Y, Goto H, Kakiuchi S, Aono Y, Huang J, Sato S, Kishuku M, Taniguchi Y, Azuma M, Kawazoe K, Sekido Y, Yano S, Akiyama S, Sone S, Minakuchi K, Kato Y, Nishioka Y
- Journal Title
  
  J Immunol
  
  Volume: 2013
- URL
  http://www.jimmunol.org/content/early/2013/05/19/jimmunol.1300448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22501048
[Journal Article] Cepharanthine is a potent reversal agent for MRP7 (ABGG10)-mediated multidrug resistance
- Author(s)
  Ying Zhou, Shin-ichi Akiyama(他11人)
- Journal Title
  
  Biochem Pharmacol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] ヒト癌細胞の ROS 産生および生存におけるチミジン異化作用の役割2012
- Author(s)
  田畑祥、秋山伸一
- Organizer
  第16回日本がん分子標的治療学会
- Place of Presentation
  西日本総合展示場(北九州市)
- Data Source
  KAKENHI-PROJECT-22501048
[Presentation] Role of Thymidine catabolism in survival of human cancer cells2012
- Author(s)
  田畑祥、秋山伸一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌(札幌市)
- Data Source
  KAKENHI-PROJECT-22501048
[Presentation] チミジンホスホリラーゼによってチミジンから派生した糖の解糖系への移行2011
- Author(s)
  田畑祥、秋山伸一
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  ホテル日航東京(東京都)
- Data Source
  KAKENHI-PROJECT-22501048
[Presentation] Thymidine-derived sugars generated by thymidine phosphorylase entered glycolytic pathway2011
- Author(s)
  田畑祥、秋山伸一
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Data Source
  KAKENHI-PROJECT-22501048
[Presentation] チミジンホスホリラーゼによる活性酸素の産生機構2010
- Author(s)
  田畑祥、秋山伸一
- Organizer
  第14回日本がん分子標的治療学会
- Place of Presentation
  タワーホール船堀(東京都)
- Data Source
  KAKENHI-PROJECT-22501048
[Presentation] Molecular basis for the production of reactive oxygen species by thymidine phosphorylase2010
- Author(s)
  田畑祥、秋山伸一
- Organizer
  第69回日本癌学会学術総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Data Source
  KAKENHI-PROJECT-22501048
[Presentation] Molecular basis for the antiangiongenic effcet of 5-FU and tegafur.2009
- Author(s)
  Shin-ichi Akiyama
- Organizer
  The 14^<th> Japanese Foundation for Cancer Researeh International Symposium on Cancer Chemotherapy "New Antitumor Agents under Develoment in the US, Europe and Japan" -In Memory of Dr. Takashi Tsuruo- Conference Room Orion
- Place of Presentation
  Hotel Nikko Tokyo, Japan
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-17016058
[Presentation] がん微小環境と抗がん剤2008
- Author(s)
  秋山伸一
- Organizer
  第29回癌免疫外科研究会
- Place of Presentation
  ホテル日航東京(東京都)
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] 第29回癌免疫外科研究会2008
- Author(s)
  秋山伸一
- Place of Presentation
  ホテル日航東京
- Year and Date
  2008-06-19
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] 腫瘍微小血管に対する5-FUとその活性化酵素の作用2008
- Author(s)
  秋山伸一
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-17016058
[Presentation] 腫瘍微小血管に対する5-FUとその活性化酵素の作用2008
- Author(s)
  秋山伸一
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(名古屋市)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] がん微小環境と抗がん剤2008
- Author(s)
  秋山伸一
- Organizer
  第29回癌免疫外科研究会
- Place of Presentation
  ホテル日航東京(東京都)
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-17016058
[Presentation] 腫瘍微小血管に対する5-FUとその活性化酵素の作用2008
- Author(s)
  秋山伸一
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] The effect of thymidine phosphorylase, 5-FU and hypoxia on tumor microenvironments.(シンポジウム)2007
- Author(s)
  Shin-chi Akiyama
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] The effect of thymidine phosphorylase, 5-FU and hypoxia on tumor microenvironments.(シンポジウム)2007
- Author(s)
  Shin-chi Akiyama
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-19590314
[Presentation] The effect of thymidine phosphorylase, 5-FU and hypoxia on tumor microenvironments.(シンポジウム)2007
- Author(s)
  Shin-chi Akiyama
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-04
- Data Source
  KAKENHI-PROJECT-17016058

1. FURUKAWA Tatsuhiko (40219100)

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110. 埴淵昌毅

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AKIYAMA Shinichi 秋山 伸一

Research Projects

Research Products

Co-Researchers

Molecular basis for thefunctions of thymidine phosphorylase and preclinical study of an inhibitor of thymidine phosphorylase , TPIPrincipal Investigator

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Analysis of physiological function of vaultsPrincipal Investigator

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Molecular targeting agents that suppress invasion and metastasis of cancer cellsPrincipal Investigator

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Search and analysis of genes involved in the sensitivity to arsenic trioxide of human cells.Principal Investigator

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腫瘍増殖・浸潤・転移を抑制する新規薬剤の開発Principal Investigator

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チミジンホスホリラーゼのがん血管新生とアポトーシスへの関与Principal Investigator

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Physiological function of thymidine phosphorylase and the involvement of the enzyme in tumor growthPrincipal Investigator

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Analysis of structure and function of GS-X pumps.Principal Investigator

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AKIYAMA Shinichi 秋山伸一