Sugimoto Yoshikazu 杉本芳一

… Alternative Names

Researcher Number	10179161
Other IDs
External Links
Affiliation (Current)	2022: 慶應義塾大学, 薬学部(芝共立), 教授
Affiliation (based on the past Project Information) *help	2018 – 2021: 慶應義塾大学, 薬学部(芝共立), 教授 2016: 慶應義塾大学, 薬学部(芝共立), 教授 2011 – 2015: 慶應義塾大学, 薬学部, 教授 2008 – 2009: Keio University, 薬学部, 教授 2004 – 2007: 共立薬科大学, 薬学部, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Clinical oncology / Tumor therapeutics
Keywords	Principal Investigator ABCG2 / ABC transporter / BCRP / SNP / estrogen / ABCB1 / がん幹細胞 / 抗癌剤耐性 / レトロウイルス / flavonoid … More Except Principal Investigator 抗癌剤耐性 / 耐性タンパク / 耐性遺伝子 / 癌転移 / ビンクリスチン / アドリアマイシン / カルシウム拮抗薬 / 細胞接着分子 / 転移と糖蛋白質 / 癌遺伝子 / 抗癌剤 / モノクローナル抗体 / 多剤耐性遺伝子 / Pー糖蛋白 / 耐性克服 / DNAトポイソメラ-ゼ / モノクロ-ナル抗体 / 耐性獲得 / メタロチオネイン / グルタチオン・チオ-ル・トランスフェラ-ゼ / 5ーフルオロウラシル耐性 / Pー糖タンパク / 転移 / 細胞接着因子 / homing receptor / 運動因子 / src関連遺伝子 / アクチン / fos遺伝子 / 遺伝的不安定性 / 耐性獲得機序 / 耐性克服剤開発 / シスプラチン / 5ーフルオロウラシル / P‐糖タンパク / ユビキチン / トポイソメラ-ゼ / P-糖タンパク / 分子標的 / アポトーシス / 癌移転 / 遺伝子治療 / ベクター開発 / カルシウム培抗薬 / 転移と血小板凝集活性 Less

複数のがん分子標的治療薬の効果を左右する薬剤耐性・感受性規定因子の統合的研究Principal Investigator
- Principal Investigator
  
  杉本芳一
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Analysis of the resistance mechanisms to molecular-targeting anticancer agentsPrincipal Investigator
- Principal Investigator
  
  Sugimoto Yoshikazu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Keio University
Identification of factors regulating the capacity for both self-renewal and pluripotent differentiation of cancer stem cells and application to cancer treatment.Principal Investigator
- Principal Investigator
  
  Sugimoto Yoshikazu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor therapeutics
- Research Institution
  Keio University
Molecular mechanism on the drug resistance and responsiveness against anticancer agents and molecular-target agentsPrincipal Investigator
- Principal Investigator
  
  SUGIMOTO Yoshikazu
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical oncology
- Research Institution
  Keio University
トランスポーターの発現・活性の制御と機能性SNPを基盤としたがん化学療法の戦略Principal Investigator
- Principal Investigator
  
  杉本芳一
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
薬物排出トランスポーターの活性制御と機能性SNPを基盤としたがん化学療法の戦略Principal Investigator
- Principal Investigator
  
  杉本芳一
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoritsu University of Pharmacy
抗がん剤耐性の克服と機能性SNPを基盤としたがん化学療法の戦略Principal Investigator
- Principal Investigator
  
  杉本芳一
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoritsu University of Pharmacy
レトロウイルス遺伝子導入を用いた抗癌剤耐性・感受性機構の研究Principal Investigator
- Principal Investigator
  
  杉本芳一
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoritsu University of Pharmacy
  Japanese Foundation For Cancer Research
癌および正常細胞の抗癌剤感受性を規定するサプレッサー型耐性因子の同定Principal Investigator
- Principal Investigator
  
  杉本芳一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
がん遺伝子治療ベクターの基礎研究
- Principal Investigator
  
  斎藤泉
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
がん細胞の薬剤感受性と抵抗性の分子機構とその制御
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
癌転移に関与する細胞側要因の解析
- Principal Investigator
  
  丹羽太貫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
新しい制がん剤耐性遺伝子群の解析と克服法の確立
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  大分医科大学
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
癌転移に関与する細胞側要因の解析
- Principal Investigator
  
  横路謙次郎
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
新しい制がん剤耐性遺伝子群の解析と克服法の確立
- Principal Investigator
  
  桑野信彦
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  大分医科大学
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
癌転移に関与する細胞側要因の解析
- Principal Investigator
  
  横路謙次郎
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
癌転移に関する基礎的研究
- Principal Investigator
  
  横路謙次郎
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Hiroshima University
制がん剤耐性機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
制がん剤耐性機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
制がん剤耐性機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2009 2007 2005

All Journal Article Presentation

[Journal Article] Effect of TNIK upregulation on JQ1-resistant human colorectal cancer HCT116 cells.2020
- Author(s)
  Takahashi Chihiro、Kondo Shingo、Sadaoka Kensuke、Ishizuka Shuhei、Noguchi Kohji、Kato Yu、Sugimoto Yoshikazu
- Journal Title
  
  Biochemical and Biophyssical Research Communications.
  
  Volume: 530 Pages: 230-234
- DOI
  10.1016/j.bbrc.2020.06.136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16339, KAKENHI-PROJECT-18K06632, KAKENHI-PROJECT-18K07302
[Journal Article] STAT1 upregulates glutaminase and modulates amino acids and glutathione metabolism2020
- Author(s)
  Kondo S, Kato Y, Minagawa S, Sugimoto Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 523 Pages: 672-677
- DOI
  10.1016/j.bbrc.2020.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-20K16339
[Journal Article] Putative molecular determinants mediating sensitivity or resistance towards carnosic acid tumor cell responses2020
- Author(s)
  Mahmoud Nuha、Saeed Mohamed E.M.、Sugimoto Yoshikazu、Klinger Anette、Fleischer Edmond、Efferth Thomas
- Journal Title
  
  Phytomedicine
  
  Volume: 77 Pages: 153271-153271
- DOI
  10.1016/j.phymed.2020.153271
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] SERCA and P-glycoprotein inhibition and ATP depletion are necessary for celastrol-induced autophagic cell death and collateral sensitivity in multidrug-resistant tumor cells.2020
- Author(s)
  Xu SW, Law BYK, Qu SLQ, Hamdoun S, Chen J, Zhang W, Guo JR, Wu AG, Mok SWF, Zhang DW, Xia C, Sugimoto Y, Efferth T, Liu L, Wong VKW.
- Journal Title
  
  Pharmacological Research
  
  Volume: 153 Pages: 104660-104660
- DOI
  10.1016/j.phrs.2020.104660
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] GZD824 Inhibits GCN2 and Sensitizes Cancer Cells to Amino Acid Starvation Stress.2020
- Author(s)
  Kato Yu、Kunimasa Kazuhiro、Takahashi Mizuki、Harada Ayaka、Nagasawa Ikuko、Osawa Masanori、Sugimoto Yoshikazu、Tomida Akihiro
- Journal Title
  
  Mol Pharmacol.
  
  Volume: 98 Pages: 669-676
- DOI
  10.1124/molpharm.120.000070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16339, KAKENHI-PUBLICLY-19H04973, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-18K19486
[Journal Article] Citrus Fruit-Derived Flavanone Glycoside Narirutin is a Novel Potent Inhibitor of Organic Anion-Transporting Polypeptides2020
- Author(s)
  Morita T, Akiyoshi T, Sato R, Uekusa Y, Katayama K, Yajima K, Imaoka A, Sugimoto Y, Kiuchi F, Ohtani H.
- Journal Title
  
  Journal of Agricultural and Food Chemistry
  
  Volume: 68 Pages: 14182-14191
- DOI
  10.1021/acs.jafc.0c06132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-18K06758, KAKENHI-PROJECT-18K07302
[Journal Article] pH-Dependent transport kinetics of human organic anion transporting polypeptide 1A2.2020
- Author(s)
  T. Morita, T Akiyoshi, R. Sato, K. Katayama, K. Yajima, H. Kataoka, A. Imaoka, Y. Sugimoto, H. Ohtani
- Journal Title
  
  Drug Metabolism and Pharmacokinetics
  
  Volume: 35 Issue: 2 Pages: 220-227
- DOI
  10.1016/j.dmpk.2019.12.002
- NAID
  50014558590
- ISSN
  1347-4367
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06758, KAKENHI-PROJECT-19K07173, KAKENHI-PROJECT-18K07302
[Journal Article] SNAIL- and SLUG-induced side population phenotype of HCT116 human colorectal cancer cells and its regulation by BET inhibitors.2020
- Author(s)
  Kato Y, Kondo S, Itakura T, Tokunaga M, Hatayama S, Katayama K, Sugimoto Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 521 Pages: 152-157
- DOI
  10.1016/j.bbrc.2019.10.094
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Cytotoxicity of cucurbitacin E from Citrullus colocynthis against multidrug-resistant cancer cells.2019
- Author(s)
  Saeed MEM, Boulos JC, Elhaboub G, Rigano D, Saab A, Loizzo MR, Hassan LEA, Sugimoto Y, Piacente S, Tundis R, Yagi S, Khalid H, Efferth T.
- Journal Title
  
  Phytomedicine
  
  Volume: 62 Pages: 152945-152945
- DOI
  10.1016/j.phymed.2019.152945
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Regorafenib-Induced Hand-Foot Skin Reaction is More Severe on the Feet than on the Hands.2019
- Author(s)
  Nonomiya Yuma、Yokokawa Takashi、Kawakami Kazuyoshi、Kobayashi Kazuo、Aoyama Takeshi、Takiguchi Tomomi、Sugisaki Takahito、Suzuki Kenichi、Suenaga Mitsukuni、Wakatsuki Takeru、Yamaguchi Kensei、Sugimoto Yoshikazu、Hama Toshihiro
- Journal Title
  
  Oncology Research
  
  Volume: 印刷中
- DOI
  10.3727/096504018x15291727589740
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07302
[Journal Article] Synthesis of 5-Hydroxy-3′,4′,7-trimethoxyflavone and Related Compounds and Elucidation of Their Reversal Effects on BCRP/ABCG2-Mediated Anticancer Drug Resistance2019
- Author(s)
  Tsunekawa R, KatayamaK, Hanaya K, Higashibayashi S, Sugimoto Y, Sugai T.
- Journal Title
  
  ChemBioChem
  
  Volume: 20 Pages: 210-220
- DOI
  10.1002/cbic.201800431
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-16K21362
[Journal Article] Novel pharmacological effects of poly (ADP-ribose) polymerase inhibitor rucaparib on the lactate dehydrogenase pathway2019
- Author(s)
  Nonomiya Y, Noguchi K, Katayama K, Sugimoto Y.
- Journal Title
  
  Biochemical and Biophysical Research Communicaions
  
  Volume: 510 Pages: 501-507
- DOI
  10.1016/j.bbrc.2019.01.133
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18J11600, KAKENHI-PROJECT-18K06632
[Journal Article] Cytotoxicity of 40 Egyptian plant extracts targeting mechanisms of drug-resistant cancer cells.2019
- Author(s)
  Hegazy MF, Abdelfatah S, Hamed AR, Mohamed TA, Elshamy AA, Saleh IA, Reda EH, Abdel-Azim NS, Shams KA, Sakr M, Sugimoto Y, Pare PW, Efferth T.
- Journal Title
  
  Phytomedicine
  
  Volume: 59 Pages: 152771-152771
- DOI
  10.1016/j.phymed.2018.11.031
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Collateral sensitivity of drug-resistant ABCB5- and mutation-activated EGFR overexpressing cells towards resveratrol due to modulation of SIRT1 expression.2019
- Author(s)
  Saeed MEM, Rahama M, Kuete V, Dawood M, Elbadawi M, Sugimoto Y, Efferth T.
- Journal Title
  
  Phytomedicine
  
  Volume: 59 Pages: 152890-152890
- DOI
  10.1016/j.phymed.2019.152890
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Heat shock protein 90 inhibitors overcome the resistance to Fms-like tyrosine kinase 3 inhibitors in acute myeloid leukemia.2018
- Author(s)
  Katayama K, Noguchi K, Sugimoto Y.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 34240-34258
- DOI
  10.18632/oncotarget.26045
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06632, KAKENHI-PROJECT-18K07302
[Journal Article] Repurposing of Bromocriptine for Cancer Therapy.2018
- Author(s)
  Seo EJ, Sugimoto Y, Greten HJ, Efferth T.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 9 Pages: 1030-1030
- DOI
  10.3389/fphar.2018.01030
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR).2018
- Author(s)
  Saeed MEM, Mahmoud N, Sugimoto Y, Efferth T, Abdel-Aziz H.
- Journal Title
  
  Frontiers in Pharmacology
  
  Volume: 9 Pages: 481-481
- DOI
  10.3389/fphar.2018.00481
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells.2018
- Author(s)
  Takami M, Katayama K, Noguchi K, Sugimoto Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 503 Pages: 1364-1371
- DOI
  10.1016/j.bbrc.2018.07.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06632, KAKENHI-PROJECT-18K07302
[Journal Article] Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells2018
- Author(s)
  Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 14827-14827
- DOI
  10.1038/s41598-018-33139-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07502, KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K19487, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-16H04716, KAKENHI-PROJECT-16H06276
[Journal Article] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells2018
- Author(s)
  Kato Y, Kunimasa K, Sugimoto Y, Tomida A.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 504 Pages: 721-726
- DOI
  10.1016/j.bbrc.2018.09.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07302, KAKENHI-PROJECT-18K07309, KAKENHI-PROJECT-16H04717
[Journal Article] Cytotoxicity of nimbolide towards multidrug-resistant tumor cells and hypersensitivity via cellular metabolic modulation.2018
- Author(s)
  Mahmoud N, Saeed MEM, Sugimoto Y, Klauck SM, Greten HJ, Efferth T.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 35762-35779
- DOI
  10.18632/oncotarget.26299
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Cytotoxicity of sesquiterpene alkaloids from Nuphar plants toward sensitive and drug-resistant cell lines.2018
- Author(s)
  Fukaya M, Nakamura S, Hegazy MEF, Sugimoto Y, Hayashi N, Nakashima S, Yoshikawa M, Efferth T, Matsuda H.
- Journal Title
  
  Food & Function
  
  Volume: 9 Pages: 6279-6286
- DOI
  10.1039/c8fo01804a
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Journal Article] Functional Effects of AKT3 on Aurora Kinase Inhibitor-induced Aneuploidy.2017
- Author(s)
  Noguchi K, Hongama K, Hariki S, Nonomiya Y, Katayama K, Sugimoto Y.
- Journal Title
  
  J Biol Chem
  
  Volume: 292(5) Pages: 1910-1924
- DOI
  10.1074/jbc.m116.747048
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460076, KAKENHI-PROJECT-15K14409
[Journal Article] APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.2017
- Author(s)
  Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama, Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya
- Journal Title
  
  Mol Cancer Ther.
  
  Volume: 16 Pages: 739-751
- DOI
  10.1158/1535-7163.mct-16-0578
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02368, KAKENHI-PROJECT-16H04715, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-15K14409, KAKENHI-PROJECT-15K14412, KAKENHI-PROJECT-16H04716
[Journal Article] RSK1 protects P-glycoprotein/ABCB1 against ubiquitin-proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2R1.2016
- Author(s)
  Katayama K, Fujiwara C, Noguchi K, Sugimoto Y.
- Journal Title
  
  Sci Rep
  
  Volume: 6 Pages: 36134-36134
- DOI
  10.1038/srep36134
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460076, KAKENHI-PROJECT-15K14409
[Journal Article] Effect of AKT3 expression on MYC- and caspase-8-dependent apoptosis caused by polo-like kinase inhibitors in HCT 116 cells.2016
- Author(s)
  Nonomiya Y, Noguchi K, Tanaka N, Kasagaki T, Katayama K, Sugimoto Y.
- Journal Title
  
  Cancer Sci
  
  Volume: 107(12) Pages: 1877-1887
- DOI
  10.1111/cas.13093
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460076, KAKENHI-PROJECT-15K14409
[Journal Article] Cytotoxicity of 35 medicinal plants from Sudan towards sensitive and multidrug-resistant cancer cells.2015
- Author(s)
  Saeed ME, Abdelgadir H, Sugimoto Y, Khalid HE, Efferth T
- Journal Title
  
  J Ethnopharmacol
  
  Volume: 174 Pages: 644-658
- DOI
  10.1016/j.jep.2015.07.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14409
[Journal Article] Upregulation of cellular glutathione levels in human ABCB5- and murine Abcb5-transfected cells.2015
- Author(s)
  Kondo S, Hongama K, Hanaya K, Yoshida R, Kawanobe T, Katayama K, Noguchi K, Sugimoto Y
- Journal Title
  
  BMC Pharmacol Toxicol
  
  Volume: 16 Pages: 37-37
- DOI
  10.1186/s40360-015-0038-5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460076, KAKENHI-PROJECT-15K14409
[Journal Article] Activity of the dietary flavonoid, apigenin, against multidrug-resistant tumor cells as determined by pharmacogenomics and molecular docking.2015
- Author(s)
  Mohamed Saeed, Yosikazu Sugimoto, et al.
- Journal Title
  
  J Nutr Biochem
  
  Volume: VOL. 26 Pages: 44-56
- DOI
  10.1016/j.jnutbio.2014.09.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300364, KAKENHI-PROJECT-15K14409
[Journal Article] Cytotoxicity of the sesquiterpene lactones neoambrosin and damsin from Ambrosia maritima against multidrug-resistant cancer cells.2015
- Author(s)
  Saeed M, Jacob S, Sandjo, L, Sugimoto Y, Khalid H, Opatz T, Thines T, Efferth T
- Journal Title
  
  Front Pharmacology
  
  Volume: 6 Pages: 267-267
- DOI
  10.3389/fphar.2015.00267
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K14409
[Journal Article] The lignan, (-)-sesamin reveals cytotoxicity toward cancer cells: pharmacogenomic determination of genes associated with sensitivity or resistance.2014
- Author(s)
  Mohamed Saeed, Yosikazu Sugimoto, et al.
- Journal Title
  
  Phytomedicine
  
  Volume: VOL. 21 Pages: 689-696
- DOI
  10.1016/j.phymed.2014.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300364
[Journal Article] Regulations of P-Glycoprotein/ABCB1/MDR1 in Human Cancer Cells.2014
- Author(s)
  Kazuhiro Katayama, Yoshikazu Sugimoto, et al.
- Journal Title
  
  New Journal of Science
  
  Volume: VOL. 2014 Pages: 476974-476974
- DOI
  10.1155/2014/476974
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23300364
[Journal Article] Human ABC transporter ABCG2/BCRP expression in chemoresistance: basic and clinical perspectives for molecular cancer therapeutics.2014
- Author(s)
  Kohji Noguchi, Yoshikazu Sugimoto, et al.
- Journal Title
  
  Pharmacogenomics and Personalized Medicine
  
  Volume: VOL. 7 Pages: 53-64
- DOI
  10.2147/pgpm.s38295
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23300364
[Journal Article] FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin-proteasome pathway in cancer cells2014
- Author(s)
  Kazuhiro Katayama, Yoshikazu Sugimoto, et al.
- Journal Title
  
  Cancer Science
  
  Volume: VOL. 345 Pages: 124-131
- DOI
  10.1016/j.canlet.2013.12.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23300364, KAKENHI-PROJECT-23590134
[Journal Article] Resistance mechanisms of cancer cells to the novel vacuolar H+-ATPase inhibitor archazolid B.2014
- Author(s)
  Rebecca Hamm, Yoshikazu Sugimoto, et al.
- Journal Title
  
  Investigational New Drugs
  
  Volume: VOL. 32 Pages: 893-903
- DOI
  10.1007/s10637-014-0134-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300364
[Journal Article] FBXO15 regulates P-glycoprotein/ABCB1 expression through the ubiquitin-proteasome pathway in cancer cells.2013
- Author(s)
  Kazuhiro Katayama, Yoshikazu Sugimoto, et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Pages: 694-702
- DOI
  10.1111/cas.12145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300364, KAKENHI-PROJECT-23590134, KAKENHI-PROJECT-23790196
[Journal Article] Biochemical Interaction of Anti-HCV Telaprevir with the ABC Transporters P-glycoprotein and Breast Cancer Resistance Protein.2013
- Author(s)
  Yurua F, Yoshikazu Sugimoto, et al.
- Journal Title
  
  BMC Research Notes
  
  Volume: 6 Pages: 445-445
- DOI
  10.1186/1756-0500-6-445
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300364, KAKENHI-PROJECT-23590134
[Journal Article] Decidua-Derived Mesenchymal Cells are a Promising Source for the Generation and Cell Banking, of Human Induced Pluripotent Stem Cells2013
- Author(s)
  Tomoko Shofuda, Yoshikazu Sugimoto, et al.
- Journal Title
  
  Cell Med
  
  Volume: 4 Pages: 125-147
- DOI
  10.3727/215517912x658918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23300364, KAKENHI-PROJECT-23689017, KAKENHI-PROJECT-24591538
[Journal Article] Breast Cancer Resistance Protein (BCRP) : a Molecular Target for Anticancer Drug Resistance and Pharmacokinetics/Pharmacodynamics.2005
- Author(s)
  Sugimoto, Y.
- Journal Title
  
  Cancer Sci. 96
  
  Pages: 457-465
- Data Source
  KAKENHI-PROJECT-17016069
[Presentation] SLUG導入HCT116細胞に対するGPX4阻害剤の効果2021
- Author(s)
  深澤ゆかり, 加藤優, 近藤慎吾, 杉本芳一.
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] Dextranによる多剤耐性関連輸送体の阻害効果2021
- Author(s)
  森本かおり, 石井敬, 杉本芳一, 荻原琢男, 富田幹雄.
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] FLT3-ITDによるintegrated stress response の誘導2021
- Author(s)
  佐々木大河, 加藤優, 片山和浩, 近藤慎吾, 杉本芳一.
- Organizer
  日本薬学会第141年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] SLUG導入HCT116細胞におけるxCTの発現上昇とフェロトーシス抵抗性2020
- Author(s)
  加藤優, 近藤慎吾, 杉本芳一.
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] GZD824のGCN2-ATF4ストレス応答経路に対する阻害効果2020
- Author(s)
  高橋瑞希, 加藤優, 國政和弘, 杉本芳一, 冨田章弘.
- Organizer
  第24回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] SLUG導入HCT116細胞におけるフェロトーシス感受性規定因子の解明2020
- Author(s)
  加藤優, 近藤慎吾, 杉本芳一.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] STAT１が関与する薬剤耐性とその克服2020
- Author(s)
  近藤慎吾, 加藤優, 杉本芳一.
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] ウイルス転写因子K-RTAによるヒトCD274/PD-L1プロモーター活性化.2019
- Author(s)
  野口耕司, 宮澤雅典, 片山和浩, 杉本芳一.
- Organizer
  第31回微生物シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] かんきつ果汁中の新規 OATP2B1 阻害成分の探索とその阻害活性の定量的評価.2019
- Author(s)
  森田時生, 秋好健志, 矢島広大, 今岡鮎子, 植草義徳, 木内文之, 片山和浩, 杉本芳一, 大谷壽一.
- Organizer
  第13回次世代を担う若手医療薬科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] 上皮間葉転換によるside population細胞の誘導解析.2019
- Author(s)
  加藤優, 片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] ABCB5発現細胞のBSO耐性機構.2019
- Author(s)
  近藤慎吾, 片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第23回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] 上皮間葉転換に伴って誘導されるside population細胞の制御.2019
- Author(s)
  加藤優, 近藤慎吾, 杉本芳一.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] 癌遺伝子BCR-ABLによる統合的ストレス応答制御機構2019
- Author(s)
  加藤優, 杉本芳一, 冨田章弘.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] BCRPを介した3’,4’-ジメトキシフラボン類の抗がん剤耐性克服作用.2019
- Author(s)
  恒川龍二, 片山和浩, 花屋賢悟, 東林修平, 杉本芳一, 須貝威.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] GSK3β阻害薬によるmultipolar spindleへの効果.2019
- Author(s)
  髙山柾, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] CAGE transcriptome analysis reveals BCL2A1 upregulation in FLT3-ITD/D835 dual mutated AML cells harboring complex co-mutations.2019
- Author(s)
  Yamatani K, Ai T, Saitoh K, Yang H, Suzuki K, Hori A, Murakami-Tonami, Y, Zhang W, Carter B, Kinjo S, Ikeo K, Katayama K, Sugimoto Y, Harada H, Miida T, Shah NP, Konopleva M, Hayashizaki Y, Andreeff M, Yoko Y.
- Organizer
  61st ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] High and low affinity kinetics of OATP2B1 - Inhibitory potency and pH-dependency of inhibitors -.2019
- Author(s)
  Sato R, Akiyoshi T, Imaoka A, Katayama K, Sugimoto Y, Ohtani H.
- Organizer
  日本薬物動態学会第34回年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] FLT3-ITDによるIntegrated Stress Response の制御.2019
- Author(s)
  佐々木大河, 加藤優, 近藤慎吾, 杉本芳一.
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] P-glycoproteinの発現を制御するタンパク質の探索.2019
- Author(s)
  在津虎次郎, 近藤慎吾, 加藤優, 片山和浩, 杉本芳一.
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] ABCB5発現細胞におけるGLS発現の増大.2019
- Author(s)
  近藤慎吾, 加藤優, 片山和浩, 杉本芳一.
- Organizer
  第78回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] JQ1耐性細胞の解析.2019
- Author(s)
  齋藤優圭, 定岡健介, 近藤慎吾, 加藤優, 野口耕司, 杉本芳一.
- Organizer
  第63回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] JQ1耐性細胞におけるcyclin E1高発現に対するTNIKの関与2019
- Author(s)
  高橋ちひろ, 野口耕司, 石塚周平, 片山和浩, 杉本芳一.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] ヒト有機アニオン輸送ポリペプチドOATP1A2のpH依存的輸送特性.2019
- Author(s)
  森田時生, 秋好健志, 今岡鮎子, 片山和浩, 杉本芳一, 大谷壽一.
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] Transactivation of CD274/PD-L1 Gene Promoter by KSHV RTA/ORF50 and Cellular SP1 Proteins.2019
- Author(s)
  Noguchi K, Miyazawa M, Katayama K, Sugimoto Y.
- Organizer
  第67回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562 cells.2018
- Author(s)
  Kato K, Kunimasa K, Sugimoto Y, Tomida A.
- Organizer
  The 23rd Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] JQ1耐性細胞におけるcyclin E1の発現上昇に対するTNIKの関与2018
- Author(s)
  高橋ちひろ, 野口耕司, 石塚周平, 片山和浩, 杉本芳一.
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] olaparib耐性細胞を用いた耐性形質の解析.2018
- Author(s)
  野々宮悠真, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] IL-10プロモーターにおけるK-RTAとSP1/3の相互作用解析2018
- Author(s)
  宮澤雅典, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] 患者由来胃がん細胞におけるCD44v陽性細胞の薬剤抵抗性への寄与とそのメカニズム2018
- Author(s)
  川上隆兵, 馬島哲夫, 熊谷厚志, 杉本芳一, 右田敏郎, 佐野武, 山口研成, 清宮啓之.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] JQ1耐性HCT 116細胞におけるTNIKの役割.2018
- Author(s)
  野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] テロメラーゼ阻害剤MST-312の新規作用機序とその制がん効果を規定する因子.2018
- Author(s)
  藤原千明, 村松由起子, 矢守隆夫, 杉本芳一, 清宮啓之.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] Poly (ADP-ribose) polymerase1 deficiency is not correlated with rucaparib and veliparib sensitivity in A2780 cells.2018
- Author(s)
  Nonomiya Y, Noguchi K, Katayama K, Sugimoto Y.
- Organizer
  The 30th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] BCR-ABLはERストレス下におけるPERK-ATF4経路の活性化および細胞生存を制御する.2018
- Author(s)
  加藤優, 杉本芳一, 冨田章弘.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] HSP90 阻害薬17-AAGはFLT3-ITD/D835変異型AML細胞の増殖を抑制する.2018
- Author(s)
  片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] アミノ酸飢餓により引き起こされるIntegrated Stress Response選択的な阻害剤の性状解析.2018
- Author(s)
  加藤優, 杉本芳一, 冨田章弘.
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] Olaparib耐性細胞は、rucaparib、veliparibに対して感受性を示した.2018
- Author(s)
  野々宮悠真, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] Heat shock protein 90 inhibitors overcome the resistance to various Fms-like tyrosine kinase 3 inhibitors.2018
- Author(s)
  Katayama K, Noguchi K, Sugimoto Y.
- Organizer
  The 30th EORTC-NCI-AACR Molecular Targets and Cancer Therapeutics Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] ヒト小腸有機アニオン輸送ポリペプチド (OATP) 1A2, 2B1 の pH sensitive な輸送特性の解析.2018
- Author(s)
  森田時生, 佐藤稜, 秋好健志, 今岡鮎子, 片山和浩, 杉本芳一, 大谷壽一.
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] Quizartinib 耐性急性骨髄性白血病における分子標的としてのHSP90.2018
- Author(s)
  片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第22回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] AKTによる染色体分離の制御.2018
- Author(s)
  髙山柾, 野口耕司, 野々宮悠真, 片山和浩, 杉本芳一.
- Organizer
  第62回日本薬学会関東支部大会
- Data Source
  KAKENHI-PROJECT-18K07302
[Presentation] ABCB5発現細胞における基質化合物の輸送及びメタボローム解析.2017
- Author(s)
  髙木佳奈, 近藤慎吾, 杉本芳一, 野口耕司, 片山和浩.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] HSP90阻害剤はquizartinib耐性細胞の増殖を抑制する.2017
- Author(s)
  片山和浩, 野口耕司, 杉本芳一.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] テロメラーゼ阻害剤 MST-312 の即時的制がん効果を規定する因子.2017
- Author(s)
  藤原千明, 村松由起子, 矢守隆夫, 杉本芳一, 清宮啓之.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] PKCalphaはPim-1Lの発現を制御する.2017
- Author(s)
  高見麻由,片山和浩, 野口耕司, 杉本芳一.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] PLK阻害剤に対する薬剤感受性規定因子の探索.2017
- Author(s)
  野々宮悠真, 野口耕司,片山和浩,杉本芳一.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] 上皮間葉転換に伴って誘導される side population 細胞の性状解析2017
- Author(s)
  徳永未来, 加藤優, 杉本芳一, 野口耕司, 片山和浩.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] KSHV RTAのIL-10プロモーター活性化におけるSp3結合領域の役割.2017
- Author(s)
  宮澤雅典, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  日本薬学会第137年会
- Place of Presentation
  仙台国際センター（仙台市）
- Year and Date
  2017-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] RSK1によるユビキチン連結酵素UBE2R1のリン酸化と抗がん剤耐性2016
- Author(s)
  片山和浩, 野口耕司, 杉本芳一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] AKT-Mycシグナルは、PLK阻害剤耐性に関与する.2016
- Author(s)
  野々宮悠真, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] ABCB5はグルタチオン合成阻害薬の効果を低下させる2016
- Author(s)
  近藤慎吾, 片山和浩, 野口耕司, 杉本芳一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-28
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] Aurora kinase阻害剤が誘導する細胞分裂不全に対するAkt3の作用.2016
- Author(s)
  野口耕司，片山和浩，杉本芳一.
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  別府国際コンベンションセンター（別府市）
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] BET阻害剤に対する耐性メカニズムの検討2016
- Author(s)
  石塚周平, 野口耕司, 片山和浩, 杉本芳一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] RSK1 regulates a ubiquitin-conjugating enzyme E2 R1 that is associated with multidrug resistance in cancer cells.2016
- Author(s)
  片山和浩, 野口耕司, 杉本芳一
- Organizer
  Tenth AACR-JCA Joint Conference,“Breakthroughs in Cancer Research: From Basic to Therapeutics”
- Place of Presentation
  Maui, HI, USA
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] FLT3-ITDのD835変異によるquizartinib耐性.2016
- Author(s)
  伊藤賢司, 片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京都）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] 大腸がん細胞株のタンキラーゼ阻害剤に対する感受性予測バイオマーカー候補因子.2016
- Author(s)
  田中伯享, 吉田喜香, 松村由起子, 杉本芳一, 清宮啓之.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] AktはAurora kinase阻害剤による細胞の巨核化を抑制する.2016
- Author(s)
  針木志織, 本釜圭太, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京都）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] P-糖タンパク質による抗がん剤耐性に対する新規治療標的としてのRSKの可能性.2016
- Author(s)
  片山和浩，野口耕司，杉本芳一.
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  別府国際コンベンションセンター（別府市）
- Year and Date
  2016-05-31
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] PKCαによるPim-1L-Ser65のリン酸化の機能解析.2016
- Author(s)
  高見麻由, 片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] PKCαによるPim-1Lの制御2016
- Author(s)
  高見麻由, 片山和浩, 野口耕司, 杉本芳一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-27
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] Aurora kinase 阻害剤耐性細胞に於いて、Akt3は細胞分裂に関するKIF23を制御する.2016
- Author(s)
  野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] RSKはUBE2R1の自己ユビキチン化を誘導し、P-糖タンパク質の分解を抑制する.2016
- Author(s)
  片山和浩, 野口耕司, 杉本芳一.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜市）
- Year and Date
  2016-10-08
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] RTAによるIL-10プロモーター活性化に働く協調分子の同定.2016
- Author(s)
  宮澤雅典, 野口耕司, 片山和浩, 杉本芳一.
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京都）
- Year and Date
  2016-09-17
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] AKT3 expression modulates chemosensitivity to aurora kinase inhibitors.2015
- Author(s)
  野口耕司, 片山和浩, 杉本芳一
- Organizer
  AACR-NCI-EORTC International Conference, Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Boston, MA, USA
- Year and Date
  2015-11-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] ABCB5遺伝子導入細胞のBSO耐性機構2015
- Author(s)
  近藤慎吾, 片山和浩, 野口耕司, 杉本芳一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] Aurora kinase 阻害剤に対する薬剤感受性規定因子の探索2015
- Author(s)
  野口耕司, 片山和浩, 杉本芳一
- Organizer
  第19回日本がん分子標的治療学会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-12
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] RSKはP-糖タンパク質／ABCB1のユビキチン化酵素UBE2R1をリン酸化する2015
- Author(s)
  片山和浩, 野口耕司, 杉本芳一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] Plk阻害薬耐性細胞における細胞死メカニズムの変化2015
- Author(s)
  野々宮悠真, 野口耕司, 片山和浩, 杉本芳一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] P-糖タンパク質／ABCB1のプロテアソーム分解におけるRSKの関与2015
- Author(s)
  片山和浩, 野口耕司, 杉本芳一
- Organizer
  第19回日本がん分子標的治療学会
- Place of Presentation
  松山全日空ホテル（愛媛県松山市）
- Year and Date
  2015-06-11
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] P-glycoproteinの発現を制御するFLT3/Pim-1シグナル経路におけるprotein kinase Cの役割2015
- Author(s)
  高見麻由, 片山和浩, 野口耕司, 杉本芳一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] 大腸癌細胞株でのタンキラーゼ阻害剤に対する感受性規定因子2015
- Author(s)
  田中伯享, 吉田喜香, 村松由起子, 杉本芳一, 清宮啓之
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-10
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] Aurora kinase阻害剤感受性に及ぼすAKT3の効果2015
- Author(s)
  野口耕司, 片山和浩, 杉本芳一
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-09
- Data Source
  KAKENHI-PROJECT-15K14409
[Presentation] 抗がん剤排出トランスポーターのSNP2012
- Author(s)
  杉本芳一
- Organizer
  第45回制癌剤適応研究会
- Place of Presentation
  国際ファッションセンター(東京都)(招待講演)
- Year and Date
  2012-03-02
- Data Source
  KAKENHI-PROJECT-23300364
[Presentation] Functional analysis of human ABCB52011
- Author(s)
  Yoshikazu Sugimoto
- Organizer
  The JSPS/iCeMS Joint International Symposium ABC 2011 in Kyoto
- Place of Presentation
  京都大学(京都府)(招待講演)
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-23300364
[Presentation] Multidrug resistance by P-glycoprotein and BCRP.2009
- Author(s)
  Yoshikazu Sugimoto
- Organizer
  The 14th Japanese Foundation for Cancer Research, International Symposium on Cancer Chemotherapy
- Place of Presentation
  東京
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20015042
[Presentation] ABCトランスポーターの発現と生理活性2009
- Author(s)
  杉本芳一
- Organizer
  第13回日本がん分子標的治療学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2009-06-25
- Data Source
  KAKENHI-PROJECT-20015042
[Presentation] Retrovirus integration site analysis of human induced pluripotent stem (iPS) cells.2009
- Author(s)
  Sugimoto Y
- Organizer
  第15回日本遺伝子治療学会
- Place of Presentation
  大阪
- Year and Date
  2009-07-11
- Data Source
  KAKENHI-PROJECT-20015042
[Presentation] ABC輸送体の遺伝子多型とがん化学療法における薬剤応答性2007
- Author(s)
  杉本芳一
- Organizer
  第30回日本分子生物学会年会第80回日本生化学会大会合同年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18015045
[Presentation] ABC transporters and signal transduction pathways.2007
- Author(s)
  Sugimoto Y
- Organizer
  The 12th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-18015045
[Presentation] A 5-year follow up of the patients who have undergone an MDR1 gene therapyagainst metastatic breast cancer.2007
- Author(s)
  杉本芳一
- Organizer
  第13回日本遺伝子治療学会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18015045
[Presentation] Recent advances in anticancer agents and future prospective.2007
- Author(s)
  杉本芳一
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-18015045

1. 鶴尾隆 (00012667)

# of Collaborated Projects: 6 results

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2. 谷口俊一郎 (60117166)

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3. 竹市雅俊 (00025454)

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4. 内藤幹彦 (00198011)

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5. 浜田洋文 (00189614)

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6. 横路謙次郎 (70034618)

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7. 村松喬 (00030891)

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8. 山本雅 (40134621)

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9. 丹羽太貫 (80093293)

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10. 桑野信彦 (80037431)

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11. 稲葉実 (60085636)

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12. 植田和光 (10151789)

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13. 八巻寛 (30013329)

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14. 河野公俊 (00153479)

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15. 秋山伸一 (60117413)

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16. 武市紀年 (40002133)

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17. 西條長宏 (00215526)

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18. 石田良司 (50150214)

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19. 藤田直也 (20280951)

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20. 冨田章弘 (40251483)

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21. 清宮啓之 (50280623)

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23. 斎藤泉 (70158913)

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26. 島田隆 (20125074)

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32. FUJIWARA chiaki

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33. MURAMATSU yukiko

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34. UENO Masaki

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35. KUNIMASA Kazuhiro

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36. AKIYOSHI Takeshi

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37. RYOUHEI Katayama

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38. MIZUTANI anna

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39. TANAKA noritaka

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40. SHOFUDA Tomoko

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41. 野口耕司

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42. 片山和浩

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43. 上野勝

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44. 井本正哉

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48. 花屋賢悟

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49. 大谷壽一

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51. 金村米博

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Sugimoto Yoshikazu 杉本 芳一

SUGIMOTO Yoshikazu 杉本 芳一

杉本 芳一 スギモト ヨシカズ

Research Projects

Research Products

Co-Researchers

複数のがん分子標的治療薬の効果を左右する薬剤耐性・感受性規定因子の統合的研究Principal Investigator

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Analysis of the resistance mechanisms to molecular-targeting anticancer agentsPrincipal Investigator

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Identification of factors regulating the capacity for both self-renewal and pluripotent differentiation of cancer stem cells and application to cancer treatment.Principal Investigator

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Molecular mechanism on the drug resistance and responsiveness against anticancer agents and molecular-target agentsPrincipal Investigator

Principal Investigator

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トランスポーターの発現・活性の制御と機能性SNPを基盤としたがん化学療法の戦略Principal Investigator

Principal Investigator

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薬物排出トランスポーターの活性制御と機能性SNPを基盤としたがん化学療法の戦略Principal Investigator

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抗がん剤耐性の克服と機能性SNPを基盤としたがん化学療法の戦略Principal Investigator

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レトロウイルス遺伝子導入を用いた抗癌剤耐性・感受性機構の研究Principal Investigator

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癌および正常細胞の抗癌剤感受性を規定するサプレッサー型耐性因子の同定Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Sugimoto Yoshikazu 杉本芳一

SUGIMOTO Yoshikazu 杉本芳一

杉本芳一スギモトヨシカズ