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Mashima Tetsuo  馬島 哲夫

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MASHIMA Tetsuo  馬島 哲夫

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Researcher Number 30311228
Other IDs
Affiliation (Current) 2022: 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 主任研究員
Affiliation (based on the past Project Information) *help 2016 – 2022: 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 主任研究員
2015: 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 主任研究員
2015: 公益財団法人がん研究会, その他部局等, 主任研究員
2015: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 主任研究員
2014: 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 主任研究員 … More
2013: 公益財団法人がん研究会, がん化学療法センター 分子生物治療研究部, 研究員
2011 – 2012: 公益財団法人がん研究会, がん化学療法センター・分子生物治療研究部, 研究員
2011 – 2012: 公益財団法人がん研究会, がん化学療法センター分子生物治療研究部, 研究員
2011: がん研究会, がん化学療法センター分子生物治療研究部, 研究員
2009: 財団法人癌研究会, 癌化学療法センター分子生物治療研究部, 研究員
2008: 癌化学療法センター, 分子生物治療研究部, 研究員
2007: Japanese Foundation For Cancer Research, 癌化学療法センター・分子生物治療研究部, 研究員
2006: (財)癌研究会, 癌化学療法センター分子生物治療研究部, 研究員
2005: (財)癌研究会, 癌化学療法センター基礎研究部, 研究員
2001 – 2004: 財団法人癌研究会, 癌化学療法センター・基礎研究部, 研究員
2002: 財団法人癌研究会, 癌研究所・癌化学療法センター・基礎研究部, 研究員
1999 – 2001: 財団法人 癌研究会, 癌化学療法センター・基礎研究部, 研究員
1998: 医薬品副作用被害救済, 研究振興調査機構, 派遣研究員 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Basic Section 50020:Tumor diagnostics and therapeutics-related / Biological pharmacy / Biological pharmacy / Medical pharmacy / Clinical oncology / Tumor therapeutics
Except Principal Investigator
Biological Sciences / Tumor biology / Tumor diagnostics / Digestive surgery / Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related
Keywords
Principal Investigator
アポトーシス / 癌 / がん幹細胞 / Apaf-1 / 分子標的治療 / 抗癌剤 / グリオキサラーゼ / 薬剤耐性 / アポトソーム / アシルCoA合成酵素 … More / アポプトソーム / 脂質代謝 / 前立腺がん / 化学療法 / トポイソメラーゼ阻害剤 / ATF3 / カスペース / 耐性 / 癌治療 / 白血病 / 耐性克服 / p53 / Hsp27 / IAP / GLO1 / Apaf-1様分子 / RNAiスクリーニング / がん分子標的治療 / 癌遺伝子 / 小胞体ストレス / 可塑性 / 大腸がん / c-KIT / タンキラーゼ / CD44 / ALDH / 胃がん / Persister細胞 … More
Except Principal Investigator
がん / バイオマーカー / 効果予測マーカー / 胃癌 / P-糖タンパク / 抗癌剤耐性 / 耐性タンパク / 耐性遺伝子 / 分子標的 / 耐性克服 / アポトーシス / 癌転移 / 癌移転 / 癌 / シグナル伝達 / ゲノム / 医療・福祉 / 薬学 / シゲナル伝達 / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 / 脂質代謝 / 細胞増殖 / 微小環境 / メタボローム / ATP-クエン酸リアーゼ / 活性酸素 / 酸化ストレス / 脂質 / 細胞死 / HER2 / Gastric cancer / HER2 heterogeneity / Trastuzumab / Biomarker / HER2 heterigeneity / トラスツズマブ / 治療効果予測因子 / Heterogeneity / Gastric Cancer / 癌幹細胞 / 放射線 / がん幹細胞 / 免疫 / 胃がん / 幹細胞 / 放射線療法 / 免疫チェックポイント阻害薬 / abscopal effect / モデル動物作製 / ゲノム編集 / 病理形態解析 / 生理機能解析 / 分子プロファイリング / トランスレーショナルリサーチ Less
  • Research Projects

    (20 results)
  • Research Products

    (111 results)
  • Co-Researchers

    (177 People)
  •  先端モデル動物支援プラットフォーム

    • Principal Investigator
      武川 睦寛
    • Project Period (FY)
      2022 – 2027
    • Research Category
      Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)
    • Research Institution
      The University of Tokyo
  •  大腸癌治療薬の基礎解析データからの血中循環バイオマーカー同定と生物学的意義の解析

    • Principal Investigator
      末永 光邦
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Tokyo Medical and Dental University
  •  胃がんの初期薬剤抵抗性を司るがん細胞の可塑性および安定維持機構の解明Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Changes in the immunological profile of gastric cancer stem cells due to irradiation

    • Principal Investigator
      KUMAGAI Koshi
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Analysis of the regulation mechanisms of colorectal cancer stem cell maintenance and plasticityPrincipal Investigator

    • Principal Investigator
      MASHIMA Tetsuo
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Identification of biomarkers for novel therapeutic agents in colorectal cancer based on preclinical analysis.

    • Principal Investigator
      MITSUKUNI SUENAGA
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor diagnostics
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Clinical impact of intratumoral HER2 heterogeneity on trastuzumab eficacy

    • Principal Investigator
      Wakatsuki Takeru
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Analysis of the mechanisms of survival and differentiation inhibition of prostate tumor-propagating cellsPrincipal Investigator

    • Principal Investigator
      Mashima Tetsuo
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Role of oncogenic factors and their cooperations in survival of prostate tumor-propagating cellsPrincipal Investigator

    • Principal Investigator
      MASHIMA Tetsuo
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical oncology
    • Research Institution
      Japanese Foundation for Cancer Research
  •  Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas

    • Principal Investigator
      IMAI Kohzoh, 中村 祐輔
    • Project Period (FY)
      2010 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Research Institution
      The University of Tokyo
  •  Lipid metabolomics to analyze the mechanisms for cellular adaptation to tumor microenvironment

    • Principal Investigator
      SEIMIYA Hiroyuki
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Tumor biology
    • Research Institution
      公益財団法人がん研究会
      Japanese Foundation For Cancer Research
  •  脂質代謝制御系を標的とした難治がん選択的治療法の開発Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
  •  アポトソーム選択的活性化化合物を用いた細胞死制御因子同定と癌治療Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Medical pharmacy
    • Research Institution
      Japanese Foundation For Cancer Research
  •  Molecular therapeutics targeting drug-resistance mechanisms

    • Principal Investigator
      TOMIDA Akihiro, 鶴尾 隆
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
      The University of Tokyo
  •  アポトーシス実行に関わるアポトソーム系制御因子の同定Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Japanese Foundation For Cancer Research
  •  癌細胞の内在性アポトーシス阻害因子とこれを標的とした抗腫瘍薬剤の探索Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
  •  アポトーシス実行に関わるApaf1およびCARD4を制御する新たな蛋白質の同定Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Japanese Foundation For Cancer Research
  •  癌細胞のアポトーシス誘導制御因子を標的とする化合物を用いた新しい癌化学療法の開発Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
  •  抗癌剤による癌細胞のアポトーシスにおける転写誘導遺伝子の同定とその機能の解析Principal Investigator

    • Principal Investigator
      馬島 哲夫
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Japanese Foundation For Cancer Research
  •  がん細胞の薬剤感受性と抵抗性の分子機構とその制御

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1994 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2005 Other

All Journal Article Presentation Book Patent

  • [Book] がん微小環境に1細胞レベルで挑む~技術革新で見えてきた腫瘍内の細胞と免疫応答の多様性、がん悪性化・治療抵抗性の鍵(がん幹細胞を支えるがん微小環境の多様性 3.薬剤耐性胃がん細胞のがん幹細胞性とその生存分子経路)2021

    • Author(s)
      馬島哲夫, 清宮啓之
    • Total Pages
      220
    • Publisher
      羊土社
    • ISBN
      9784758103961
    • Data Source
      KAKENHI-PROJECT-21K07251
  • [Book] 別冊 医学のあゆみ 治療標的としてのがん幹細胞「がん幹細胞と薬剤耐性」2021

    • Author(s)
      馬島哲夫、清宮啓之
    • Total Pages
      6
    • Publisher
      医歯薬出版
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Book] マウス・ラットモデル作製・解析プロフェッショナル(オミックス解析:表現型・薬物活性とリンクする分子経路の探索)2021

    • Author(s)
      室井誠, 馬島哲夫, 牛嶋大, 松浦正明
    • Total Pages
      320
    • Publisher
      羊土社
    • ISBN
      9784758121125
    • Data Source
      KAKENHI-PROJECT-21K07251
  • [Book] ゲノム解析に基づく新しい分子標的治療 : ゲノムワイドな解析および統合的解析による前立腺がん幹細胞の分子標的探索(「がん分子標的治療」)2015

    • Author(s)
      馬島哲夫、清宮啓之
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Book] がん分子標的治療 12巻 4号 ゲノムワイドな解析および統合的解析による前立腺がん幹細胞の分子標的探索2014

    • Author(s)
      馬島哲夫, 清宮啓之
    • Total Pages
      5
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Book] The Lipid 25巻 4号 がんと脂質代謝2014

    • Author(s)
      馬島哲夫, 右田敏郎, 清宮啓之
    • Total Pages
      7
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Book] 特集・制がん剤の分子標的スクリーニング成績 化学療法基盤支援活動報告-制がん候補物質のスクリーニング成績・第15報2013

    • Author(s)
      矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘
    • Publisher
      癌と化学療法社
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Book] 特集・制がん剤の分子標的スクリーニング成績 「化学療法基盤情報支援班」報告‐制がん候補物質のスクリーニング成績・第15報『癌と化学療法オンライン』2013

    • Author(s)
      矢守隆夫, 上原至雅, 深澤秀輔, 吉田稔, 井本正哉, 清宮啓之, 馬島哲夫, 水上民夫, 川田学, 長田裕之, 旦慎吾, 松浦正明, 掛谷秀昭, 冨田章弘.
    • Publisher
      癌と化学療法社
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Book] がんと脂質代謝 実験医学 302012

    • Author(s)
      右田敏郎、馬島哲夫、清宮啓之
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Book] 癌の分子標的治療-アポトーシス3)p53、アポトソームなど2008

    • Author(s)
      馬島 哲夫
    • Publisher
      南山堂(印刷中)
    • Data Source
      KAKENHI-PROJECT-18015048
  • [Book] 癌の分子標的治療-アポトーシス3)p53、アポトソームなど2008

    • Author(s)
      馬島 哲夫
    • Publisher
      南山堂(印刷中)
    • Data Source
      KAKENHI-PROJECT-18790134
  • [Book] がんにおける脂質代謝、実験医学増刊号「がんと代謝」

    • Author(s)
      右田敏郎、馬島哲夫、清宮啓之
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Journal Article] Potential Molecular Cross Talk Among CCR5 Pathway Predicts Regorafenib Responsiveness in Metastatic Colorectal Cancer Patients.2021

    • Author(s)
      SUENAGA MITSUKUNI、ZHANG WU、MASHIMA TETSUO、SCHIRRIPA MARTA、CAO SHU、OKAZAKI SATOSHI、BERGER MARTIN D.、MIYAMOTO YUJI、BARZI AFSANEH、YAMAGUCHI TOSHIHARU、LENZ HEINZ-JOSEF
    • Journal Title

      Cancer Genomics Proteomics

      Volume: 18 Pages: 317-324

    • DOI

      10.21873/cgp.20262

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K07235, KAKENHI-PROJECT-21K07251
  • [Journal Article] Serum IL-8 level as a candidate prognostic marker of response to anti-angiogenic therapy for metastatic colorectal cancer.2021

    • Author(s)
      Suenaga Mitsukuni、Mashima Tetsuo、Kawata Naomi、Wakatsuki Takeru、Dan Shingo、Seimiya Hiroyuki、Yamaguchi Kensei
    • Journal Title

      Int J Colorectal Dis

      Volume: 36 Pages: 131-139

    • DOI

      10.1007/s00384-020-03748-y

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-21K07251
  • [Journal Article] Neutralization of the induced VEGF-A potentiates the therapeutic effect of an anti-VEGFR2 antibody on gastric cancer in vivo.2021

    • Author(s)
      Mashima Tetsuo、Wakatsuki Takeru、Kawata Naomi、Jang Myung-Kyu、Nagamori Akiko、Yoshida Haruka、Nakamura Kenichi、Migita Toshiro、Seimiya Hiroyuki、Yamaguchi Kensei
    • Journal Title

      Sci Rep

      Volume: 11 Pages: 15125-15125

    • DOI

      10.1038/s41598-021-94584-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K21555, KAKENHI-PUBLICLY-20H04789, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-18K08720, KAKENHI-PROJECT-21K07251
  • [Journal Article] Lamellarin 14, a derivative of marine alkaloids, inhibits the T790M/C797S mutant epidermal growth factor receptor2021

    • Author(s)
      Nishiya N, Oku Y, Ishikawa C, Fukuda T, Dan S, Mashima T, Ushijima M, Matsuura M, Tomida A, Seimiya H, Yamori T, Iwao M, Uehara Y, et al.
    • Journal Title

      Cancer Sci

      Volume: - Pages: 1963-1974

    • DOI

      10.1111/cas.14839

    • Description
      in press
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K05715, KAKENHI-PUBLICLY-20H04789, KAKENHI-PROJECT-18K09526, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-20K21555, KAKENHI-PROJECT-19H01806, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-19H03526, KAKENHI-PROJECT-21K07251
  • [Journal Article] ALDH1A3-mTOR axis as a therapeutic target for anticancer drug-tolerant persister cells in gastric cancer.2020

    • Author(s)
      Kawakami R, Mashima T, Kawata N, Kumagai K, Migita T, Sano T, Mizunuma N, Yamaguchi K, Seimiya H.
    • Journal Title

      Cancer Sci.

      Volume: 111 Pages: 962-973

    • DOI

      10.1111/cas.14316

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-19K09136, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-16H06276
  • [Journal Article] Epidermal growth factor receptor mRNA expression: A potential molecular escape mechanism from regorafenib.2020

    • Author(s)
      Matsusaka Satoshi、Hanna Diana L.、Ning Yan、Yang Dongyun、Cao Shu、Berger Martin D.、Miyamoto Yuji、Suenaga Mitsukuni、Dan Shingo、Mashima Tetsuo、Seimiya Hiroyuki、Zhang Wu、Lenz Heinz‐Josef
    • Journal Title

      Cancer Sci

      Volume: 111 Pages: 441-450

    • DOI

      10.1111/cas.14273

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
  • [Journal Article] c-KIT regulates stability of cancer stemness in CD44-positive colorectal cancer cells.2020

    • Author(s)
      Tomizawa Fumiya、Jang Myung-Kyu、Mashima Tetsuo、Seimiya Hiroyuki
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 527 Pages: 1014-1020

    • DOI

      10.1016/j.bbrc.2020.05.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-18K07337
  • [Journal Article] Tankyrase Inhibitors Target Colorectal Cancer Stem Cells via AXIN-Dependent Downregulation of c-KIT Tyrosine Kinase2020

    • Author(s)
      Jang MK, Mashima T, Seimiya H
    • Journal Title

      Mol Cancer Ther

      Volume: 19 Issue: 3 Pages: 765-776

    • DOI

      10.1158/1535-7163.mct-19-0668

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07337, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-16H06276
  • [Journal Article] Phase II trial of biweekly cetuximab and irinotecan as third-line therapy for pretreated KRAS exon 2 wild-type colorectal cancer.2020

    • Author(s)
      Suenaga Mitsukuni、Wakatsuki Takeru、Mashima Tetsuo、Ogura Mariko、Ichimura Takashi、Shinozaki Eiji、Nakayama Izuma、Osumi Hiroki、Ota Yumiko、Takahari Daisuke、Chin Keisho、Seimiya Hiroyuki、Yamaguchi Kensei
    • Journal Title

      Invest New Drugs

      Volume: 印刷中 Pages: 111-119

    • DOI

      10.1007/s10637-019-00749-9

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-16H04716, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
  • [Journal Article] Meeting report of the 14th Japan-Korea joint symposium on cancer and aging research: current status of translational research and approaches to precision medicine.2019

    • Author(s)
      Sueoka Eisaburo、Watanabe Tatsuro、Mashima Tetsuo、Shirakami Yohei、Komori Atsumasa、Matsuo Keitaro、Yoshikawa Hiroshi Y.、Cho Kyung A、Park Tae Jun、Seimiya Hiroyuki、Kim Eung-Gook、Suganuma Masami、Chung Junho
    • Journal Title

      J Cancer Res Clin Oncol.

      Volume: 印刷中 Pages: 1263-1271

    • DOI

      10.1007/s00432-019-02887-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09850, KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-18K07968, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523
  • [Journal Article] In silico chemical screening identifies epidermal growth factor receptor as a therapeutic target of drug-tolerant CD44v9-positive gastric cancer cells.2019

    • Author(s)
      Mashima T, Iwasaki R, Kawata N, Kawakami R, Kumagai K, Migita T, Sano T, Yamaguchi K, Seimiya H.
    • Journal Title

      Br J Cancer

      Volume: 121 Pages: 846-856

    • DOI

      10.1038/s41416-019-0600-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07337, KAKENHI-PROJECT-19K09136, KAKENHI-PUBLICLY-18H04633, KAKENHI-PROJECT-19H03523, KAKENHI-PROJECT-16H06276
  • [Journal Article] Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib2018

    • Author(s)
      Suenaga M, Schirripa M, Cao S, Zhang W, Yang D, Ning Y, Cremolini C, Antoniotti C, Borelli B, Mashima T, Okazaki S, Berger MD, Miyamoto Y, Gopez R Jr., Barzi A, Lonardi S, Yamaguchi T, Falcone A, Loupakis F, Lenz HJ
    • Journal Title

      Clinical Colorectal Cancer

      Volume: 印刷中

    • DOI

      10.1016/j.clcc.2018.02.010

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06860, KAKENHI-PROJECT-18K07280, KAKENHI-PROJECT-18K07337
  • [Journal Article] Cancer Stem Cells (CSCs) as a Rational Therapeutic Cancer Target, and Screening for CSC-targeting Drugs2017

    • Author(s)
      MASHIMA T
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 2 Pages: 129-132

    • DOI

      10.1248/yakushi.16-00229-1

    • NAID

      130005305863

    • ISSN
      0031-6903, 1347-5231
    • Language
      Japanese
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Journal Article] Pharmaceutical Sciences Advancing Molecular Cancer Therapeutics<br/>&#xFF5E;To Improve Rationale and Effectiveness of Molecularly Targeted Drugs&#xFF5E;2017

    • Author(s)
      NOGUCHI K, MASHIMA T
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 137 Issue: 2 Pages: 127-128

    • DOI

      10.1248/yakushi.16-00229-f

      10.1248/yakushi.16-00229-F

    • NAID

      130005305798

    • ISSN
      0031-6903, 1347-5231
    • Language
      Japanese
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-26460076
  • [Journal Article] APC Mutations as a Potential Biomarker for Sensitivity to Tankyrase Inhibitors in Colorectal Cancer.2017

    • Author(s)
      Noritaka Tanaka, Tetsuo Mashima, Anna Mizutani, Ayana Sato, Aki Aoyama, Bo Gong, Haruka Yoshida, Yukiko Muramatsu, Kento Nakata, Masaaki Matsuura, Ryohei Katayama, Satoshi Nagayama, Naoya Fujita, Yoshikazu Sugimoto, Hiroyuki Seimiya
    • Journal Title

      Mol Cancer Ther.

      Volume: 16 Pages: 739-751

    • DOI

      10.1158/1535-7163.mct-16-0578

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H02368, KAKENHI-PROJECT-16H04715, KAKENHI-PROJECT-16H04716, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-15K14409, KAKENHI-PROJECT-15K14412
  • [Journal Article] Serum VEGF-A and CCL5 levels as candidate biomarkers for efficacy and toxicity of regorafenib in patients with metastatic colorectal cancer.2016

    • Author(s)
      Suenaga M, Mashima T, Kawata N, Wakatsuki T, Horiike Y, Matsusaka S, Dan S, Shinozaki E, Seimiya H, Mizunuma N, Yamaguchi K, Yamaguchi T.
    • Journal Title

      Oncotarget

      Volume: 7(23) Pages: 34811-34823

    • DOI

      10.18632/oncotarget.9187

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-15K06860
  • [Journal Article] Comprehensive transcriptomic analysis of molecularly targeted drugs in cancer for target pathway evaluation.2015

    • Author(s)
      Mashima T, Ushijima M, Matsuura M, Tsukahara S, Kunimasa K, Furuno A, Saito S, Kitamura M, Soma-Nagae T, Seimiya H, Dan S, Yamori T, Tomida A
    • Journal Title

      Cancer Sci

      Volume: in press Pages: 909-20

    • DOI

      10.1111/cas.12682

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25430120, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-26640109, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061
  • [Journal Article] TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival by regulation of endoplasmic reticulum chaperone expression.2014

    • Author(s)
      Mashima T, Soma-Nagae T, Migita T, Kinoshita R, Iwamoto A, Yuasa T, Yonese J, Ishikawa Y, Seimiya H
    • Journal Title

      Cancer Research

      Volume: 74 Pages: 4888-4897

    • DOI

      10.1158/0008-5472.can-13-3718

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-26430177, KAKENHI-PROJECT-221S0001
  • [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds2013

    • Author(s)
      Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M
    • Journal Title

      Cancer Sci

      Volume: 104 Pages: 360-368

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Journal Article] Development of a gene expression database and related analysis programs for evaluation of anticancer compounds2013

    • Author(s)
      Ushijima M, Mashima T, Tomida A, Dan S, Saito S, Furuno A, Tsukahara S, Seimiya H, Yamori T, Matsuura M.
    • Journal Title

      Cancer Science

      Volume: 104(3) Pages: 360-360

    • DOI

      10.1111/cas.12071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22240092, KAKENHI-PROJECT-22300341, KAKENHI-PROJECT-23501319, KAKENHI-PROJECT-23701067, KAKENHI-PROJECT-24240042, KAKENHI-PROJECT-24650626, KAKENHI-PROJECT-24650639, KAKENHI-PROJECT-25290060, KAKENHI-PROJECT-25290061, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-23117527
  • [Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication2011

    • Author(s)
      Mashima T, Seimiya H
    • Journal Title

      Tumors of the Central Nervous System

      Volume: 1 Pages: 337-340

    • Data Source
      KAKENHI-PROJECT-23501319
  • [Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication2011

    • Author(s)
      Mashima, T., Seimiya, H.
    • Journal Title

      Tumors of the Central Nervous System

      Volume: 1 Pages: 337-340

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer2011

    • Author(s)
      Mashima, T., Okabe, S., Seimiya, H.
    • Journal Title

      Mol Cell Pharmacol

      Volume: 3 Pages: 7-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer2011

    • Author(s)
      Mashima T, Okabe S, Seimiya H
    • Journal Title

      Mol Cell Pharmacol

      Volume: 3 Pages: 7-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer2011

    • Author(s)
      Mashima T, et al
    • Journal Title

      Mol Cell Pharmacol

      Volume: 3 Pages: 7-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Journal Article] Molecular pharmacological approach reveals potential new strategies to suppress androgen receptor signaling in prostate cancer.2011

    • Author(s)
      Mashima T
    • Journal Title

      Mol Cell Pharmacol

      Volume: 3 Pages: 7-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Journal Article] Role of acyl-CoA synthetases in glioma cell survival and its therapeutic implication.2011

    • Author(s)
      Mashima T
    • Journal Title

      Tumors of the Central Nervous System

      Volume: 1 Pages: 337-340

    • Data Source
      KAKENHI-PROJECT-23501319
  • [Journal Article] Pharmacological targeting of constitutively active truncated androgen receptor by nigericin and suppression of hormone-refractory prostate cancer cell growth2010

    • Author(s)
      Mashima, T., Okabe, S., Seimiya, H.
    • Journal Title

      Mol Pharmacol

      Volume: 78 Pages: 846-854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Journal Article] De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy.2009

    • Author(s)
      Mashima T
    • Journal Title

      Br J Cancer (Epub ahead of print)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide2009

    • Author(s)
      Mashima T, Sato S, Okabe S, Miyata S, Matsuura M, Sugimoto Y, Tsuruo T, Seimiya H.
    • Journal Title

      Cancer Sci. 100

      Pages: 1556-62

    • NAID

      10027193846

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions2009

    • Author(s)
      Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H.
    • Journal Title

      Oncogene 28

      Pages: 9-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy2009

    • Author(s)
      Mashima T, Seimiya H, Tsuruo T.
    • Journal Title

      Br J Cancer. 100

      Pages: 1369-72

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] Acyl-CoA synthetase as a cancer survival factor: its inhiibition enhances the efficacy of etoposide.2009

    • Author(s)
      Mashima T
    • Journal Title

      Cancer Sci (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.2009

    • Author(s)
      Mashima T
    • Journal Title

      Oncogene 8

      Pages: 9-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] p-53-defective tumors with a functional apoptosome-mediated pathway : a new therapeutic target.2005

    • Author(s)
      Mashima, T., et al.
    • Journal Title

      J.Nat'l Cancer Inst. 97

      Pages: 765-777

    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway: a new therapeutic target2005

    • Author(s)
      Mashima T, Oh-hara T, Sato S, Mochizuki M, Sugimoto Y, Yamazaki K, Hamada J, Tada M, Moriuchi T, Ishikawa Y, Kato Y, Tomoda H, Yamori T, Tsuruo T.
    • Journal Title

      J Natl Cancer Inst. 97

      Pages: 765-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] Defects of the apoptotic pathway as therapeutic target against cancer2005

    • Author(s)
      Mashima T, Tsuruo T.
    • Journal Title

      Drug Resist Updat. 8

      Pages: 339-43

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Journal Article] Defects of the apoptotic pathway as therapeutic target against cancer.2005

    • Author(s)
      Tetsuo Mashima
    • Journal Title

      Drug Resist.Updat. 8

      Pages: 339-343

    • Data Source
      KAKENHI-PROJECT-15790057
  • [Journal Article] p53-defective tumors with a functional apoptosome-mediated pathway : a new therapeutic target.2005

    • Author(s)
      Tetsuo Mashima
    • Journal Title

      J.Natl.Cancer Inst. 97

      Pages: 765-777

    • Data Source
      KAKENHI-PROJECT-15790057
  • [Patent] マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キット、及びバイオマーカー2015

    • Inventor(s)
      末永光邦、水沼信之、馬島哲夫、清宮啓之
    • Industrial Property Rights Holder
      公益財団法人がん研究会
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-251386
    • Filing Date
      2015-12-24
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Patent] マルチキナーゼ阻害剤の有効性と安全性を予測する検査方法、検査キッ ト、及びバイオマー カー2015

    • Inventor(s)
      末永光邦、水沼信之、馬島哲夫、清宮啓之
    • Industrial Property Rights Holder
      末永光邦、水沼信之、馬島哲夫、清宮啓之
    • Industrial Property Rights Type
      特許
    • Filing Date
      2015-12-24
    • Data Source
      KAKENHI-PROJECT-15K06860
  • [Patent] 癌の予防、治療剤2007

    • Inventor(s)
      馬島哲夫, 他
    • Industrial Property Rights Holder
      癌研究会, 他
    • Filing Date
      2007-10-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18790134
  • [Patent] 癌の予防、治療剤2007

    • Inventor(s)
      馬島哲夫他
    • Industrial Property Rights Holder
      癌研究会他
    • Acquisition Date
      2007-10-18
    • Overseas
    • Data Source
      KAKENHI-PROJECT-18015048
  • [Presentation] Identification of THAP12 as a response determinant of colorectal cancer stem cells to DNA topoisomeraseⅠinhibitors2021

    • Author(s)
      Shun Morino, Tetsuo Mashima, Minoru Yoshida, Hiroyuki Seimiya
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K07251
  • [Presentation] Innate drug resistance of ALDH1A3-enriched cancer cell subpopulation and its plasticity in gastric cancer2021

    • Author(s)
      Tetsuo Mashima, Ryuhei Kawakami, Koshi Kumagai, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K07251
  • [Presentation] Evaluation of predictive biomarkers for tankyrase inhibitor sensitivity using patient-derived colorectal cancer cells2021

    • Author(s)
      Mingjue Chen, Tetsuo Mashima, Yukiko Muramatsu, Yuki Shimizu, Satoshi Nagayama, Ryohei Katayama, Hiroyuki Seimiya
    • Organizer
      第80回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-21K07251
  • [Presentation] 胃がん細胞集団に存在するALDH1A3高発現がん細胞の薬剤抵抗性への寄与2021

    • Author(s)
      馬島哲夫、清宮啓之
    • Organizer
      第25回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-21K07251
  • [Presentation] c-KIT maintains CD44-positive colorectal cancer stem cells.2020

    • Author(s)
      Tomizawa F, Jang MK, Mashima T, Seimiya H
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] ALDH1A3は制がん剤処理後の残存胃がん細胞で発現亢進し、増殖と造腫瘍性に寄与する2020

    • Author(s)
      馬島哲夫、川上隆兵、清宮啓之
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] shRNAスクリーニングによる大腸がん幹細胞の新規治療標的分子の探索2020

    • Author(s)
      森野峻、馬島哲夫、吉田稔、清宮啓之
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] ALDH1A3 as a marker and therapeutic target for residual gastric cancer cells after anticancer drug treatment.2020

    • Author(s)
      Tetsuo Mashima, Ryuhei Kawakami, Koshi Kumagai, Toshiro Migita, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
    • Organizer
      第79回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] 受容体型チロシンキナーゼc-KITによる大腸がん幹細胞性の維持2020

    • Author(s)
      冨澤文弥、張明キュ、馬島哲夫、清宮啓之
    • Organizer
      第24回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] Tankyrase Inhibitors target colorectal cancer stem-like cells through an AXIN-dependent mechanisms2019

    • Author(s)
      Jang MK, Mashima T, Seimiya H
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] EGFR inhibitors suppress drug-tolerant CD44v+ gastric cancer cell growth and enhance the antitumor effect of irinotecan2019

    • Author(s)
      Tetsuo Mashima, Risa Iwasaki, Ryuhei Kawakami, Koshi Kumagai, Toshiro Migita, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
    • Organizer
      第78回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] タンキラーゼ阻害剤による大腸がん幹細胞の増殖抑制とその分子機序2019

    • Author(s)
      張明きゅ、馬島哲夫 , 清宮啓之
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] EGFR阻害剤は胃がん薬剤抵抗性に寄与するCD44v発現細胞の増殖を抑制し、イリノテカンの治療効果を増強する2019

    • Author(s)
      馬島哲夫 , 岩崎里紗, 川上隆兵, 清宮啓之
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] Targeting colorectal cancer stem cells by tankyrase inhibition2018

    • Author(s)
      Tetsuo Mashima, Hiroyuki Seimiya
    • Organizer
      第41回日本分子生物学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] Targeting colorectal cancer stem-like CD44-positive cells by tankyrase inhibitors2018

    • Author(s)
      Tetsuo Mashima, Myungkyu Jang, Hiroyuki Seimiya
    • Organizer
      14th Japan-Korea Joint Symposium on Cancer and Aging Research
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] Identification of biomarkers for TAS-102 efficacy in metastatic colorectal cancer patients based on preclinical analysis and clinical validation.2018

    • Author(s)
      Suenaga, M., Mashima, T., Kawata, N., Dan, S., Wakatsuki, T., Shinozaki, E., Ichimura, T., Ogura, M., Takahari, D., Osumi, H., Ota, Y., Chin, K., Seimiya, H., Yamaguchi, K., Yamaguchi, T.
    • Organizer
      ASCO 2018 Gastrointestinal Cancer Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06860
  • [Presentation] 胃がんの薬剤耐性に寄与するCD44v陽性細胞を標的とする化合物のin silico探索2018

    • Author(s)
      馬島哲夫 , 岩崎里紗, 川上隆兵, 清宮啓之 他
    • Organizer
      第22回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] In silico screening for agents targeting drug-tolerant CD44v-positive cells in patient-derived gastric cancer.2018

    • Author(s)
      Tetsuo Mashima, Risa Iwasaki, Koshi Kumagai, Ryuhei Kawakami, Takeshi Sano, Kensei Yamaguchi, Hiroyuki Seimiya
    • Organizer
      第77回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-18K07337
  • [Presentation] Role of genetic polymorphisms in CCL5/CCR5 axis to predict efficacy of regorafenib in patients with refractory metastatic colorectal cancer.2017

    • Author(s)
      Suenaga, M., Schirripa, M., Cao, S., Zhang, W., Yang, D., Marmorino, F., Bergamo, F., Antoniotti, C., Rossini, D., Ning, Y., Okazaki, S., Berger , M., Miyamoto, Y., Gopez, R., Hanna, D., Barzi, A., Mashima, T., Yamaguchi, T., Loupakis, F., Lenz , H.
    • Organizer
      ASCO 2017 Gastrointestinal Cancer Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K06860
  • [Presentation] がん治療標的としてのがん幹細胞と標的薬剤の探索2016

    • Author(s)
      馬島哲夫
    • Organizer
      第136回日本薬学会年会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-03-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] 大腸がん幹細胞様CD44陽性細胞に対するタンキラーゼ阻害剤の増殖抑制作用2016

    • Author(s)
      馬島哲夫、張明奎、村松由起子、清宮啓之
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府国際コンベンションセンター
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] 大腸がん幹細胞様CD44陽性細胞に対するタンキラーゼ阻害剤の増殖抑制効果2016

    • Author(s)
      馬島哲夫、村松由起子、清宮啓之
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] Gene signature-based approach identifies mTOR as a downstream factor of TRIB1-dependent survival pathways in prostate cancer2016

    • Author(s)
      Tetsuo Mashima, Ryoko Kinoshita, Sachiko Okabe, Hiroyuki Seimiya
    • Organizer
      Tenth AACR-JCA Joint Conference on Breakthroughs in Cancer Research: From Biology to Therapeutics
    • Place of Presentation
      Hyatt Regency Maui Resort and Spa
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] 再燃性前立腺がんにおける短鎖型アンドロゲン受容体の役割とその制御物質2014

    • Author(s)
      岡部幸子、馬島哲夫、清宮啓之
    • Organizer
      文科省新学術領域研究・がん支援「化学療法基盤支援活動」第三回シンポジウムアカデミアからの抗がん剤創薬に向けて-天然物の有効利用
    • Place of Presentation
      万国津梁館(沖縄県・名護市)
    • Year and Date
      2014-05-12
    • Data Source
      KAKENHI-PROJECT-221S0001
  • [Presentation] 遺伝子発現解析とRNAi 探索による前立腺がん腫瘍源細胞生存因子の同定2013

    • Author(s)
      馬島哲夫
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2013-10-03
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] 遺伝子発現解析とRNAi探索による前立腺がん腫瘍源細胞生存因子の同定2013

    • Author(s)
      馬島哲夫、清宮啓之
    • Organizer
      第72回日本癌学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] RNAi スクリーニングおよび遺伝子発現データを用いた統合的解析による前立腺がん幹細胞選択的生存因子の同定2013

    • Author(s)
      馬島哲夫
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2013-06-12
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] RNAiスクリーニングおよび遺伝子発現データを用いた統合的解析による前立腺がん幹細胞生存因子の同定2013

    • Author(s)
      馬島哲夫、湯浅健、清宮啓之
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] 前立腺がん幹細胞を標的とする薬剤の探索系構築と化合物スクリーニング2012

    • Author(s)
      馬島哲夫
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      北九州
    • Year and Date
      2012-06-28
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] 前立腺がん幹細胞を標的とする化合物のスクリーニング2012

    • Author(s)
      馬島哲夫
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-19
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] 前立腺がんのがん化と生存におけるTMPRSS2・ERG融合遺伝子の役割2012

    • Author(s)
      馬島哲夫
    • Organizer
      第12回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] 前立腺がんの癌化および生存におけるTMPRSS2-ERG 融合遺伝子の役割2011

    • Author(s)
      馬島哲夫
    • Organizer
      第70回日本癌学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-03
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] Role of TMPRSS2-ERG fusion protein in transformation and maintenance of prostate cancer2011

    • Author(s)
      馬島哲夫
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] 前立腺がんの癌化および生存におけるTMPRSS2-ERG融合遺伝子産物の役割2011

    • Author(s)
      馬島哲夫
    • Organizer
      第15回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] Involvement of constitutively active truncated androgen receptor(tAR) in hormone-refractory prostate cancer growth and the tAR inhibition by nigericin2011

    • Author(s)
      Mashima T., Okabe S., Seimiya H.
    • Organizer
      第10回日韓がん老化合同シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Presentation] ナイジェリシンによる恒常活性化型アンドロゲン受容体の抑制はホルモン再燃性前立腺がん細胞増殖を阻害する2011

    • Author(s)
      馬島哲夫、岡部幸子、清宮啓之
    • Organizer
      第11回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-01-29
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Presentation] 前立腺がんの癌化および生存におけるTMPRSS2-ERG 融合遺伝子産物の役割2011

    • Author(s)
      馬島哲夫
    • Organizer
      第15回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-22
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] がん細胞の増殖・生存における脂質代謝酵素の役割2010

    • Author(s)
      岡部幸子、右田敏郎、馬島哲夫、清宮啓之
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22650230
  • [Presentation] 内分泌療法抵抗性前立腺がんにおけるアンドロゲン受容体シグナル評価系の構築2008

    • Author(s)
      馬島 哲夫
    • Organizer
      第8回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-19
    • Data Source
      KAKENHI-PROJECT-18790134
  • [Presentation] 内分泌療法抵抗性前立腺がんにおけるアンドロゲン受容体シグナル評価系の構築2008

    • Author(s)
      馬島 哲夫
    • Organizer
      第8回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-19
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Presentation] 脂肪酸代謝酵素アシルCoAシンターゼ5による脳腫瘍細胞の生存促進と遺伝子発現解析による分子機序の検討2008

    • Author(s)
      馬島哲夫
    • Organizer
      第12回がん分子標的治療研究会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Presentation] Acyl-CoA synthetase as a survival factor of cancer: itsinhibition enhnces the efficacy of cancer chemotherapy.2008

    • Author(s)
      馬島哲夫
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2008-10-29
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Presentation] 内分泌療法抵抗性前立腺がんにおけるアンドロゲン受容体シグナル評価系の構築2008

    • Author(s)
      馬島 哲夫
    • Organizer
      第8回関東ホルモンと癌研究会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-19
    • Data Source
      KAKENHI-PROJECT-18015048
  • [Presentation] Involvement of Acyl-CoA synthetase 5 in survival of human glioma cells2007

    • Author(s)
      馬島 哲夫
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18015048
  • [Presentation] グリオーマ生存における脂肪酸代謝酵素アシルCoAシンターゼの関与とその分子機構2007

    • Author(s)
      馬島 哲夫
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-06
    • Data Source
      KAKENHI-PROJECT-18790134
  • [Presentation] グリオーマ生存における脂肪酸代謝酵素アシルCoAシンターゼの関与とその分子機構2007

    • Author(s)
      馬島 哲夫
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-06
    • Data Source
      KAKENHI-PROJECT-18015048
  • [Presentation] グリオーマ生存における脂肪酸代謝酵素アシルCoAシンターゼの関与とその分子機構2007

    • Author(s)
      馬島 哲夫
    • Organizer
      第11回がん分子標的治療研究会総会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-06
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Presentation] Involvement of Acyl-CoA synthetase 5 in survival of human glioma cells2007

    • Author(s)
      馬島 哲夫
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18790134
  • [Presentation] Involvement of Acyl-CoA synthetase 5 in survival of human glioma cells2007

    • Author(s)
      馬島哲夫
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-17016012
  • [Presentation] TRIB1 supports prostate tumorigenesis and tumor-propagating cell survival via the regulation of endoplasmic reticulum chaperone expression

    • Author(s)
      馬島哲夫
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] 前立腺がん幹細胞を標的とする薬剤の探索系構築と化合物スクリーニ ング

    • Author(s)
      馬島哲夫
    • Organizer
      第16回日本がん分子標的治療学会学術集会
    • Place of Presentation
      北九州
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] Functional genomic approach identified TRIB1 as an oncogenic survival factor in prostate cancer stem-like cells

    • Author(s)
      馬島哲夫
    • Organizer
      第19回 International Symposium on Cancer Chemotherapy
    • Place of Presentation
      科学未来館
    • Year and Date
      2014-12-10 – 2014-12-11
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] 前立腺がん幹細胞を標的とする化合物のスクリーニング

    • Author(s)
      馬島哲夫
    • Organizer
      第71回日本癌学会学術集会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23501319
  • [Presentation] RNAi探索による前立腺がん形成・腫瘍源細胞生存因子TRIB1の同定

    • Author(s)
      馬島哲夫
    • Organizer
      第6回日本RNAi研究会
    • Place of Presentation
      グランドプリンス広島
    • Year and Date
      2014-08-28 – 2014-08-30
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] TRIB1による前立腺がんの腫瘍増殖および腫瘍源細胞の生存維持

    • Author(s)
      馬島哲夫
    • Organizer
      第18回日本がん分子標的治療学会学術集会
    • Place of Presentation
      仙台市情報産業プラザ
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-26430177
  • [Presentation] An essential factor for prostate tumorigenesis and tumor-propagating cell survival identified by functional genomics and transcriptome analyses

    • Author(s)
      馬島哲夫
    • Organizer
      第12回日韓がん老化合同シンポジウム
    • Place of Presentation
      埼玉県立がんセンター
    • Year and Date
      2014-06-19 – 2014-06-21
    • Data Source
      KAKENHI-PROJECT-26430177
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  • 176.  西谷 直之
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  • 177.  福田 勉
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