TOKINO Takashi 時野隆至

… Alternative Names

Researcher Number	40202197
Other IDs
External Links
Affiliation (Current)	2021: 札幌医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2001 – 2019: Sapporo Medical University School of Medicine, Professor, 医学部, 教授 2007: 札幌医大, 医学部, 教授 2002 – 2003: 札幌医科大学, 医学部・附属がん研究所, 教授 2000: 札幌医科大学, 附属がん研究所, 教授 1999 – 2000: 札幌医科大学, 医学部・がん研究所, 教授 … More
Review Section/Research Field	Principal Investigator Digestive surgery / Surgical dentistry / Biological Sciences / Tumor biology / Human genetics / Complex systems / Basic Section 50010:Tumor biology-related Except Principal Investigator Biological Sciences / Obstetrics and gynecology / Cerebral neurosurgery … More
Keywords	Principal Investigator p53 / 癌 / アポトーシス / がん抑制遺伝子 / 細胞周期 / 遺伝子治療 / p63 / p73 / がん / トランスレーショナルリサーチ … More Except Principal Investigator p53 / 卵巣癌 / angiogenesis / 癌 / がん遺伝子 / シグナル伝達 / p63 / p73 / 転写因子 / アポトーシス / BAI1 / glioma / glioblastoma / Tet-On / gene therapy / bag-1 / hsp70 / DNA microarray / 家族性大腸腺腫症 / MCC遺伝子 / 染色体欠失 / 遺伝子増幅 / 染色体地図 / 腎癌 / 乳癌 / 染色体転座 / RFLP / 癌の遺伝子診断 / 消化器癌 / 肺癌 / 神経芽腫 / 白血病 / 遺伝子診断 / 癌遺伝子 / 癌抑制遺伝子 / がん抑制遺伝子 / がん細胞 / DNA修復 / がん転移 / ヒトゲノム / 2国間協同研究 / 2国間共同研究 / 胃がん / 連鎖解析 / 罹患同胞対法 / 全ゲノムスキャニング / DNA多型マーカー / マイクロサテライトマーカー / 発がん / 遺伝要因 / 発現制御 / 発生・分化 / マイクロアレイ / 2-D電気泳動 / プロテオミクス / 抗癌剤耐性 / cDNAマイクロアレイ / エピジェネティックス / メチル化 / MCA法 / TCF2 / エピジェネティクスの異常 / TMS1 / ASC / Fanconi-anemia / BRAC pathway / 細胞周期M期 / CyclinB / 微小管阻害剤(タキサン系抗癌剤) / 発生 / 細胞分化 / 臨床腫瘍学 / エピジェネティクス / 遺伝子 / 歯学 / 若手支援 / 国際研究者交流 / 遺伝子改変マウス / 病理形態学 / ゲノムコーホート研究 / 次世代分子解析技術 / アカデミア創薬 / ゲノム・エピゲノム解析支援 / 個別化がん予防 / 国際交流 / ATL発症予防 / 分子疫学コーホート研究 / がん化学予防 / ATL発がん機序 / ATL発症リスク / がん分子標的薬剤 / カルニチン / カルニチントランスポーター / 脂肪肝 / 原発性カルニチン欠乏症 / 低血糖症 / 心肥大 / ミトコンドリア / 高アンモニア血症 / カルニチン輸送担体 / Carnitine / Carnitine Transporter / fatty liver / primary carnitine deficiency / hypoglycemia / cardiomegaly / mitochondria / hyperammonemia / astrocytoma / angiogenssis / 子宮内膜癌 / β-catenin遺伝子 / DNAmicroarray / taxol誘導アポトーシス / Taxiol誘発apoptosis / DNA修複遺伝子 / ベーターカテニン / SKT-11 / インターロイキン6 / Bcl-2 / Tax01 / Docetaxel / DNA修復遺伝子 / ベータカテニン / SKT11 / ovarian cancer / endometrial cancer / beta-catemn gene / Taxol-induced apoptosis / もやもや病 / 遺伝子解析 / サイトカイン / Moyamoya disease / microsatelite analysis / familial occurrence / 次世代DNAシーケンサー / 新規ゲノム配列決定 / リシーケンシング / エピゲノム / RNA-Seq / 1細胞解析 / メタゲノム解析 / スーパーコンピューター / ゲノムアッセンブル / ゲノム多型 / メタゲノム / ゲノムアノテーション Less

p53 pathway and its potential targeted therapeutic approachPrincipal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Sapporo Medical University
A better understanding of p53 network for cancer therapyPrincipal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Sapporo Medical University
先進ゲノム解析研究推進プラットフォーム
- Principal Investigator
  
  小原雄治
- Principal Investigator(Support)
  
  小原雄治
- Project Period (FY)
  2016 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources
- Research Institution
  National Institute of Genetics
バイオインフォマティクスを活用したp53ネットワーク探索と癌治療への応用Principal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Sapporo Medical University
New insights into p53 signaling regulation to cure cancerPrincipal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  Sapporo Medical University
High-throughput screening for peptides that inhibit the interaction or MDM4 with p53Principal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University
Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
- Principal Investigator
  
  IMAI Kohzoh, 中村祐輔
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  The University of Tokyo
RNA干渉技術を駆使してアポトーシス誘導シグナルを増強した遺伝子治療法の開発Principal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University
Expression analysis of SFRP family genes for development of molecular targeted therapy for oral cancer
- Principal Investigator
  
  SOGABE Yohei
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University
Functional analysis of CHFR: Diagnostic and therapeutic application for oral squamous cell cancerPrincipal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University
デジタルゲノムスキャニング法の開発と胃癌関連遺伝子探索への応用Principal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University
Diagnostic and therapeutic application of cell-cycle checkpoint genes for oral squamous cell cancer.Principal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University
p53 family : function and cancer therapyPrincipal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
p53遺伝子ファミリーの機能解析とがん治療への応用Principal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  2005 – 2009
- Research Institution
  Sapporo Medical University
デジタルゲノムスキャニング法の開発と消化器癌関連遺伝子探索への応用Principal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Digestive surgery
- Research Institution
  Sapporo Medical University
p53転写制御因子ファミリーの細胞分化における役割
- Principal Investigator
  
  佐々木泰史
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Diagnostic and therapeutic application of checkpoint gene CHFR in oral squamous cell cancer.Principal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  Sapporo Medical University
遺伝子あるいは発現プロテオミクス解析を用いた婦人科癌抗癌剤耐性の分子標的の研究
- Principal Investigator
  
  SAGAE Satoru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Sapporo Medical University
卵巣癌におけるエピジェネティクスの異常の解析と治療への応用についての研究
- Principal Investigator
  
  藤井美穂
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Sapporo Medical University
転写制御因子p63の発生,分化における役割
- Principal Investigator
  
  SASAKI Yasushi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
Investigation of causative gene of familial occurrence of idiopathic occlusion of Willis ring
- Principal Investigator
  
  HOUKIN Kiyohiro
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Sapporo Medical University
Function of p53 and its target genesPrincipal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Sapporo Medical University
ヨーロッパなどががん研究先進国との研究交流
- Principal Investigator
  
  黒木登志夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Showa University
罹患同胞対法を用いた胃がん関連遺伝子の解明
- Principal Investigator
  
  笹月健彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyushu University
Functional analysis of p53-target genes.Principal Investigator
- Principal Investigator
  
  TOKINO Takashi
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Sapporo Medical University
Genetic analyses for DNA replication error, beta-catenin gene, SKT11 etc.among the patients with gynecologic cancer
- Principal Investigator
  
  SAGAE Satoru
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Sapporo Medical University
BAI1 expression in human glioma
- Principal Investigator
  
  ARITA Norio
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Hyogo College of Medicine
  Osaka University
Positional cloning of carnitine trasporter gene and its comtribution to the pathophysiological changes
- Principal Investigator
  
  KUWAJIMA Masamichi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内分泌・代謝学
- Research Institution
  The University of Tokushima
癌抑制遺伝子の単離とそのヒト癌における遺伝子異常の解明Principal Investigator
- Principal Investigator
  
  時野隆至, 中村祐輔
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
  Japanese Foundation For Cancer Research
がんの遺伝子診断
- Principal Investigator
  
  珠玖洋
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Mie University
乳癌・大腸癌における癌抑制遺伝子の単離
- Principal Investigator
  
  中村祐輔
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research
癌抑制遺伝子解析のためのヒト第3染色体遺伝的地図の作成および遺伝子の同定
- Principal Investigator
  
  中村祐輔
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Human genetics
- Research Institution
  Japanese Foundation For Cancer Research
DNA増幅法(PCR法)による高多型VNTRマ-カ-の単離Principal Investigator
- Principal Investigator
  
  時野隆至
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Human genetics
- Research Institution
  Japanese Foundation For Cancer Research

[Book] Clinical Genomicsを目指した半導体NGSによるがんゲノム解析. 実験医学32(11)2014
- Author(s)
  丸喜明、佐々木泰史、中村友紀、横井左奈、大平美紀、時野隆至、永瀬浩喜
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Pathogenesis of multiple pancreatic cancers involves multicentric carcinogenesis and intrapancreatic metastasis.2020
- Author(s)
  Fujita Y, Matsuda S, Sasaki Y, Masugi Y, Kitago M, Yagi H, Abe Y, Shinoda M, Tokino T, Sakamoto M, Kitagawa Y.
- Journal Title
  
  Cancer Sci
  
  Volume: 111 Pages: 739-748
- DOI
  10.1111/cas.14268
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-18K15094, KAKENHI-PROJECT-16H06279
[Journal Article] p53-induced ARVCF modulates the splicing landscape and supports the tumor suppressive function of p532020
- Author(s)
  Suzuki, N. Idogawa, M. Tange, S. Ohashi, T. Sasaki, Y. Nakase, H. Tokino, T.
- Journal Title
  
  Oncogene
  
  Volume: 39 Pages: 2202-2211
- DOI
  10.1038/s41388-019-1133-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122
[Journal Article] Chemotherapy after progression on nivolumab is essential for responders with genetic alterations of driver gene : Review of two recurrent/metastatic oral squamous cell carcinoma patients.2020
- Author(s)
  Ogi K, Kobayashi J, Nakagaki T, Okamoto J, Koike K, Hirokawa N, Someya M, Sakamoto H, Takada K, Tokino T, Sasaki Y, Hiratsuka H, Miyazaki A.
- Journal Title
  
  Oral Oncol.
  
  Volume: 102 Pages: 104509-104509
- DOI
  10.1016/j.oraloncology.2019.104509
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K10292, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16H06279
[Journal Article] A subset of diffuse-type gastric cancer is susceptible to mTOR inhibitors and checkpoint inhibitors2019
- Author(s)
  Fukamachi H., Kim S., K., Koh J., Lee H. S., Sasaki Y., Yamashita K., Nishikawaji T., Shimada S., Akiyama Y., Byeon S. J., Bae D. H., Okuno K., Nakagawa M., Tanioka T., Inokuchi M., Kawachi H., Tsuchiya K., Kojima K., Tokino T., Eishi Y., Kim Y. S., Kim W. H., Yuasa Y., Tanaka S.
- Journal Title
  
  J Exp Clin Cancer Res
  
  Volume: 38 Pages: 127-127
- DOI
  10.1186/s13046-019-1121-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K08647, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K19535, KAKENHI-PROJECT-18K19575, KAKENHI-PROJECT-16H02670, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-15K06832, KAKENHI-PROJECT-16H06279
[Journal Article] Renal angiomyolipoma (AML) harboring a missense mutation of TSC2 with copy-neutral loss of heterozygosity (CN-LOH)2019
- Author(s)
  Idogawa Masashi、Hida Tokimasa、Tanaka Toshiaki、Ohira Noriaki、Tange Shoichiro、Sasaki Yasushi、Uhara Hisashi、Masumori Naoya、Tokino Takashi、Natori Hiroshi
- Journal Title
  
  Cancer Biology & Therapy
  
  Volume: 21 Pages: 315-319
- DOI
  10.1080/15384047.2019.1702406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122
[Journal Article] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling2019
- Author(s)
  Ishiguro K., Kitajima H., Niinuma T., Ishida T., Maruyama R., Ikeda H., Hayashi T., Sasaki H., Wakasugi H., Nishiyama K., Shindo T., Yamamoto E., Kai M., Sasaki Y., Tokino T., Nakase H., Suzuki H.
- Journal Title
  
  Haematologica
  
  Volume: 104 Pages: 155-165
- DOI
  10.3324/haematol.2018.191262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15959, KAKENHI-PROJECT-16H06279, KAKENHI-PROJECT-19K17438, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19H03518
[Journal Article] Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1.2019
- Author(s)
  Nishiyama K, Maruyama R, Niinuma T, Kai M, Kitajima H, Toyota M, Hatanaka Y, Igarashi T, Kobayashi JI, Ogi K, Dehari H, Miyazaki A, Yorozu A, Yamamoto E, Idogawa M, Sasaki Y, Sugai T, Tokino T, Hiratsuka H, Suzuki H.
- Journal Title
  
  Cell Death Dis
  
  Volume: 9 Pages: 826-826
- DOI
  10.1038/s41419-018-0893-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-18K17174, KAKENHI-PROJECT-16K11729, KAKENHI-PROJECT-16H06279
[Journal Article] Genomic characterization for familial cases with urothelial carcinoma2019
- Author(s)
  Shindo T, Hirobe M, Adachi Y, Sasaki Y, Tokino T, Masumori N
- Journal Title
  
  Int Cancer Conf J
  
  Volume: 8 Pages: 185-189
- DOI
  10.1007/s13691-019-00381-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122
[Journal Article] Prognostic Effect of Long Noncoding RNA NEAT1 Expression Depends on p53 Mutation Status in Cancer2019
- Author(s)
  Idogawa, M. Nakase, H. Sasaki, Y. Tokino, T.
- Journal Title
  
  Journal of Oncology
  
  Volume: 1 Pages: 4368068-4368068
- DOI
  10.1155/2019/4368068
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-19K08372, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285
[Journal Article] UHRF1 depletion and HDAC inhibition reactivate epigenetically silenced genes in colorectal cancer cells.2019
- Author(s)
  Niinuma Takeshi、Kitajima Hiroshi、Kai Masahiro、Yamamoto Eiichiro、Yorozu Akira、Ishiguro Kazuya、Sasaki Hajime、Sudo Gota、Toyota Mutsumi、Hatahira Tomo、Maruyama Reo、Tokino Takashi、Nakase Hiroshi、Sugai Tamotsu、Suzuki Hiromu
- Journal Title
  
  Clin Epigenetics
  
  Volume: 11 Pages: 70-70
- DOI
  10.1186/s13148-019-0668-3
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-19K17468, KAKENHI-PROJECT-19K18736, KAKENHI-PROJECT-19H03518, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700
[Journal Article] FGFR Signaling as a Candidate Therapeutic Target for Cancers Resistant to Carbon Ion Radiotherapy2019
- Author(s)
  Darwis, N. D. M. Nachankar, A. Sasaki, Y. Matsui, T. Noda, S. E. Murata, K. Tamaki, T. Ando, K. Okonogi, N. Shiba, S. Irie, D. Kaminuma, T. Kumazawa, T. Anakura, M. Yamashita, S. Hirakawa, T. Kakoti, S. Hirota, Y. Tokino, T. Iwase, A. Ohno, T. Shibata, A. Oike, T. Nakano, T.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 20 Pages: 4563-4563
- DOI
  10.3390/ijms20184563
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-19K07645, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K11130, KAKENHI-PROJECT-17H04713
[Journal Article] Targeted next-generation sequencing of 50 cancer-related genes in Japanese patients with oral squamous cell carcinoma2018
- Author(s)
  Nakagaki T., Tamura M., Kobashi K., Omori A., Koyama R., Idogawa M., Ogi K., Hiratsuka H., Tokino T., Sasaki Y.
- Journal Title
  
  Tumour Biol
  
  Volume: 40 Pages: 0-0
- DOI
  10.1177/1010428318800180
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-16H06279
[Journal Article] Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs.2018
- Author(s)
  Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H.
- Journal Title
  
  Exp Ther Med
  
  Volume: 15 Pages: 1339-1359
- DOI
  10.3892/etm.2017.5533
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16K18445, KAKENHI-PROJECT-16H06279
[Journal Article] Surface microstructures are associated with mutational intratumoral heterogeneity in colorectal tumors2018
- Author(s)
  Harada T., Yamamoto E., Yamano H. O., Aoki H., Matsushita H. O., Yoshikawa K., Takagi R., Harada E., Tanaka Y., Yoshida Y., Eizuka M., Yorozu A., Sudo G., Kitajima H., Niinuma T., Kai M., Sasaki Y., Tokino T., Sugai T., Nakase H., Suzuki H.
- Journal Title
  
  J Gastroenterol
  
  Volume: 53 Pages: 1241-1252
- DOI
  10.1007/s00535-018-1481-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-17K09387, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15956, KAKENHI-PROJECT-16H06279
[Journal Article] Mutational analysis of uterine cervical cancer that survived multiple rounds of radiotherapy.2018
- Author(s)
  Nuryadi E, et al
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 32642-32652
- DOI
  10.18632/oncotarget.25982
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07706, KAKENHI-PROJECT-15K09989, KAKENHI-PROJECT-16H06279
[Journal Article] Target amplicon exome-sequencing identifies promising diagnosis and prognostic markers involved in RTK-RAS and PI3K-AKT signaling as central oncopathways in primary central nervous system lymphoma2018
- Author(s)
  Takashima Y., Sasaki Y., Hayano A., Homma J., Fukai J., Iwadate Y., Kajiwara K., Ishizawa S., Hondoh H., Tokino T., Yamanaka R.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 27471-27486
- DOI
  10.18632/oncotarget.25463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K09001, KAKENHI-PROJECT-16H05441, KAKENHI-PROJECT-16K10766, KAKENHI-PROJECT-16H06279
[Journal Article] Epigenetic silencing of miR-200b is associated with cisplatin resistance in bladder cancer.2018
- Author(s)
  Shindo T, Niinuma T, Nishiyama N, Shinkai N, Kitajima H, Kai M, Maruyama R, Tokino T, Masumori N, Suzuki H.
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 24457-24469
- DOI
  10.18632/oncotarget.25326
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-16K11017, KAKENHI-PROJECT-16H06279
[Journal Article] Dysregulation of miRNA in chronic hepatitis B is associated with hepatocellular carcinoma risk after nucleos(t)ide analogue treatment.2018
- Author(s)
  Wakasugi H, Takahashi H, Niinuma T, Kitajima H, Oikawa R, Matsumoto N, Takeba Y, Otsubo T, Takagi M, Ariizumi Y, Suzuki M, Okuse C, Iwabuchi S, Nakano M, Akutsu N, Kang JH, Matsui T, Yamada N, Sasaki H, Yamamoto E, Kai M, Sasaki Y, Sasaki, Tanaka, Yotsuyanagi, Tsutsumi, Yamamoto, Tokino T , Nakase H, Suzuki H, Itoh F
- Journal Title
  
  Cancer Lett.
  
  Volume: 434 Pages: 91-100
- DOI
  10.1016/j.canlet.2018.07.019
- NAID
  130007556169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-18K07949, KAKENHI-PROJECT-18K15220, KAKENHI-PROJECT-17K15959
[Journal Article] p53 mediates the suppression of cancer cell invasion by inducing LIMA1/EPLIN2017
- Author(s)
  Tomoko Ohashi, Masashi Idogawa, Yasushi Sasaki, Takashi Tokino
- Journal Title
  
  Cancer Lett
  
  Volume: 390 Pages: 58-66
- DOI
  10.1016/j.canlet.2016.12.034
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16J05870, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-26460944
[Journal Article] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing.2017
- Author(s)
  Nakagaki T, Tamura M, Kobashi K, Kobashi K, Koyama R, Fukushima H, Ohashi T, Idogawa M, Ogi K, Hiratsuka H, Tokino T, Sasaki Y.
- Journal Title
  
  Oncotarget
  
  Volume: 8 Pages: 59113-59122
- DOI
  10.18632/oncotarget.19262
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06279
[Journal Article] Long non-coding RNA NEAT1 is a transcriptional target of p53 and modulates p53-induced transactivation and tumor-suppressor function2017
- Author(s)
  Masashi Idogawa, Tomoko Ohashi, Yasushi Sasaki, Hiroshi Nakase, Takashi Tokino
- Journal Title
  
  Int J Cancer
  
  Volume: 印刷中 Pages: 2785-2791
- DOI
  10.1002/ijc.30689
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J05870, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944
[Journal Article] Fledglings in p53 signaling network2017
- Author(s)
  Tokino T, Idogawa M, Sasaki Y
- Journal Title
  
  Oncotarget
  
  Volume: 8 Pages: 55768-55769
- DOI
  10.18632/oncotarget.19229
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944
[Journal Article] The effect of forced expression of mutated K-RAS gene on gastrointestinal cancer cell lines and the IGF-1R targeting therapy.2017
- Author(s)
  Matsunaga Y, Adachi Y, Sasaki Y, Koide H, Motoya M, Nosho K, Takagi H, Yamamoto H, Sasaki S, Arimura Y, Tokino T, Carbone DP, Imai K, Shinomura Y.
- Journal Title
  
  Mol Careinog
  
  Volume: VOL. 56 Issue: 2 Pages: 515-526
- DOI
  10.1002/mc.22513
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Assessment of the quality of DNA from various formalin-fixed paraffin-embedded (FFPE) tissues and the use of this DNA for next-generation sequencing (NGS) with no artifactual mutation.2017
- Author(s)
  Einaga N, Yoshida A, Noda H, Suemitsu M, Nakayama Y, Sakurada A, Kawaji Y, Yamaguchi H, Sasaki Y, Tokino T, Esumi M.
- Journal Title
  
  PLoS One
  
  Volume: 12
- DOI
  10.1371/journal.pone.0176280
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06279
[Journal Article] Downregulation of miR-186 is associated with metastatic recurrence of gastrointestinal stromal tumors.2017
- Author(s)
  Niinuma T, Kai M, Kitajima H, Yamamoto E, Harada T, Maruyama R, Nobuoka T, Kanda T, Hasegawa T, Tokino T, Sugai T, Shimomura Y, Nakase H, Suzuki H
- Journal Title
  
  Oncol Lett
  
  Volume: 14 Pages: 5703-5710
- DOI
  10.3892/ol.2017.6911
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-17K08700, KAKENHI-PROJECT-17K09387, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-16H05419, KAKENHI-PROJECT-16K15600, KAKENHI-PROJECT-16K19352, KAKENHI-PROJECT-15K08973
[Journal Article] Identification and characterization of a metastatic suppressor BRMSIL as target gene of p53.2017
- Author(s)
  Koyama R, Tamura M, Nakagaki T, Ohashi T, Idogawa M, Suzuki H, Tokino T, Sasaki Y.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 2413-2421
- DOI
  10.1111/cas.13420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-17K09354, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-16H06279
[Journal Article] Identification and characterization of the intercellular adhesion molecule-2 gene as a novel p53 target2016
- Author(s)
  Sasaki Y, Tamura M, Takeda K, Ogi K, Nakagaki T, Koyama R, Idogawa M, Hiratsuka H, Tokino T
- Journal Title
  
  Oncotarget
  
  Volume: VOL. 7 Pages: 61426-61437
- DOI
  10.18632/oncotarget.11366
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16K09285, KAKENHI-PROJECT-26460944
[Journal Article] TET1 depletion induces aberrant CpG methylation in colorectal cancer cells.2016
- Author(s)
  Kai M, Niinuma T, Kitajima H, Yamamoto E, Harada T, Aoki H, Maruyama R, Toyota M, Sasaki Y, Sugai T, Tokino T, Nakase H, Suzuki H.
- Journal Title
  
  PLoS One.
  
  Volume: 11
- DOI
  10.1371/journal.pone.0168281
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
[Journal Article] Plasticity of lung cancer stem-like cells is regulated by the transcription factor HOXA5 that is induced by oxidative stress.2016
- Author(s)
  Hiroshi Saijo, Yoshihiko Hirohashi, et al.
- Journal Title
  
  Oncotarget
  
  Volume: 2;7(31) Pages: 50043-50056
- DOI
  10.18632/oncotarget.10571
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04722, KAKENHI-PROJECT-16H05451, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
[Journal Article] A genomic screen for long noncoding RNA genes epigenetically silenced by aberrant DNA methylation in colorectal cancer.2016
- Author(s)
  Kumegawa K, Maruyama R, Yamamoto E, Ashida M, Kitajima H, Tsuyada A, Niinuma T, Kai M, Yamano H, Sugai T, Tokino T, Shinomura Y, Imai K, Suzuki H.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 26699-26699
- DOI
  10.1038/srep26699
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-16H06297
[Journal Article] Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing.2016
- Author(s)
  Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22 Pages: 2284-2293
- DOI
  10.3748/wjg.v22.i7.2284
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-16K07122, KAKENHI-PROJECT-26460944
[Journal Article] One-dimensional sliding of p53 along DNA is accelerated in the presence of Ca2+ or Mg2+ at millimolar concentrations2015
- Author(s)
  Murata A, Ito Y, Kashima R, Kanbayashi S, Nanatani K, Igarashi C, Okumura M, Inaba K, Tokino T, Takahashi S, Kamagata K
- Journal Title
  
  J. Mol. Biol.
  
  Volume: 427 Pages: 2663-2678
- DOI
  10.1016/j.jmb.2015.06.016
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PUBLICLY-15H01626, KAKENHI-PLANNED-25104007, KAKENHI-PROJECT-15H04335, KAKENHI-PROJECT-13J04030, KAKENHI-PROJECT-26650045, KAKENHI-PROJECT-26840045, KAKENHI-PROJECT-26282213, KAKENHI-PUBLICLY-15H01625, KAKENHI-PLANNED-26116005
[Journal Article] A screen for epigenetically silenced microRNA genes in gastrointestinal stromal tumors2015
- Author(s)
  Isosaka M, Niinuma T, Nojima M, Kai M, Yamamoto E, Maruyama R, Nobuoka T, Nishida T, Kanda T, Taguchi T, Hasegawa T, Tokino T, Hirata K, Suzuki H, Shinomura Y
- Journal Title
  
  PLoS One.
  
  Volume: 10
- DOI
  10.1371/journal.pone.0133754
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-26640110, KAKENHI-PROJECT-26860514
[Journal Article] Analysis of the molecular features of rectal carcinoid tumors to identify new biomarkers that predict biological malignancy.2015
- Author(s)
  Mitsuhashi K, Yamamoto I, Kurihara H, Kanno S, Ito M, Igarashi H, Ishigami K, Sukawa Y, Tachibana M, Takahashi H, Tokino T, Maruyama R, Suzuki H, Imai K, Shinomura Y, Yamamoto H, Nosho K
- Journal Title
  
  Oncotarget
  
  Volume: 6 Pages: 22114-22125
- DOI
  10.18632/oncotarget.4294
- NAID
  130005161488
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-26640101
[Journal Article] Relation between Ku80 and microRNA-99a expression and late rectal bleeding after radiotherapy for prostate cancer.2015
- Author(s)
  Someya M, Yamamoto H, Nojima M, Hori M, Tateoka K, Nakata K, Takagi M, Saitoh M, Hirokawa N, Tokino T, Sakata K
- Journal Title
  
  RADIOTHERAPY AND ONCOLOGY
  
  Volume: in press Pages: 235-239
- DOI
  10.1016/j.radonc.2015.04.008
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24591845, KAKENHI-PROJECT-24591846, KAKENHI-PROJECT-25861114, KAKENHI-PROJECT-25430115
[Journal Article] Molecular diagnostics of a single drug-resistant multiple myeloma case using targeted next-generation sequencing2015
- Author(s)
  Ikeda H, Ishiguro K, Igarashi T, Aoki Y, Hayashi T, Ishida T, Sasaki Y, Tokino T, Shinomura Y.
- Journal Title
  
  ONCOTARGETS AND THERAPY
  
  Volume: 8 Pages: 2805-2815
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430115
[Journal Article] Epigenetic silencing of NTSR1 is associated with lateral and noninvasive growth of colorectal tumors.2015
- Author(s)
  Kamimae S, Yamamoto E, Kai M, Niinuma T, Yamano HO, Nojima M, Yoshikawa K, Kimura T, Takagi R, Harada E, Harada T, Maruyama R, Sasaki Y, Tokino T, Shinomura Y, Sugai T, Imai K, Suzuki H
- Journal Title
  
  Oncotarget.
  
  Volume: 6 Pages: 29975-29990
- DOI
  10.18632/oncotarget.5034
- NAID
  130005161526
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08973, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-15K15584, KAKENHI-PROJECT-15K18431, KAKENHI-PROJECT-221S0001, KAKENHI-PROJECT-15H04299, KAKENHI-PROJECT-25460420, KAKENHI-PROJECT-26640101
[Journal Article] The CRKL oncogene is downregulated by p53 through miR-200s.2015
- Author(s)
  Tamura M, Sasaki Y, Kobashi K, Takeda K, Nakagaki T, Idogawa M, Tokino T.
- Journal Title
  
  Cancer Sci
  
  Volume: 106 Pages: 1033-1040
- DOI
  10.1111/cas.12713
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-26460944
[Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells.2014
- Author(s)
  Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 7540-7548
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25134715
[Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells.2014
- Author(s)
  Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T
- Journal Title
  
  Oncotarget
  
  Volume: 5 Pages: 7540-7548
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25430115
[Journal Article] MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.2014
- Author(s)
  Ito M, Mitsuhashi K, Igarashi H, Nosho K, Yamamoto H
- Journal Title
  
  International Journal of Cancer
  
  Volume: (Epub ahead of print) Issue: 11 Pages: 2507-15
- DOI
  10.1002/ijc.28920
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-26640101, KAKENHI-PROJECT-221S0001
[Journal Article] Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53-binding sites.2014
- Author(s)
  Idogawa M, Ohashi T, Sasaki Y, Maruyama R, Kashima L, Suzuki H, Tokino T
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 23 Issue: 11 Pages: 2847-2857
- DOI
  10.1093/hmg/ddt673
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-25461705, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-221S0001
[Journal Article] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.2014
- Author(s)
  Tamura M, Sasaki Y, Koyama R, Takeda K, Idogawa M, Tokino T
- Journal Title
  
  Oncogene
  
  Volume: (in press) Issue: 40 Pages: 4837-46
- DOI
  10.1038/onc.2013.427
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929, KAKENHI-PROJECT-26460944, KAKENHI-PROJECT-221S0001
[Journal Article] Array-based genome-wide RNAi screening to identify shRNAs that enhance p53-related apoptosis in human cancer cells2014
- Author(s)
  Idogawa M, Ohashi T, Sugisaka J, Sasaki Y, Suzuki H, Tokino T
- Journal Title
  
  Oncotarget
  
  Volume: 5 Issue: 17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-221S0001
[Journal Article] Clinical Genomicsを目指した半導体NGSによるがんゲノム解析2014
- Author(s)
  丸喜明，佐々木泰史，中村友紀，横井左奈，大平美紀，時野隆至，永瀬浩喜
- Journal Title
  
  実験医学（羊土社）
  
  Volume: 32 Pages: 1781-1788
- Data Source
  KAKENHI-PUBLICLY-25134715
[Journal Article] Clinical Genomicsを目指した半導体NGSによるがんゲノム解析2014
- Author(s)
  丸喜明，佐々木泰史，中村友紀，横井左奈，大平美紀，時野隆至，永瀬浩喜
- Journal Title
  
  羊土社
  
  Volume: 32 Pages: 1781-1788
- Data Source
  KAKENHI-PROJECT-25430115
[Journal Article] Methylation of a panel of microRNA genes is a novel biomarker for detection of bladder cancer.2013
- Author(s)
  Shimizu T, Suzuki H, Nojima M, Kitamura H, Yamamoto E, Maruyama R, Ashida M, Hatahira T, Kai M, Masumori N, Tokino T, Imai K, Tsukamoto T, Toyota M
- Journal Title
  
  European Urology
  
  Volume: 63 Pages: 91-100
- DOI
  10.1016/j.eururo.2012.11.030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-221S0001
[Journal Article] DNA methyltransferase 1 is essetial for initiation of the colon cancers2013
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  Morita R,Hirohashi Y,Suzuki H, et al
- Journal Title
  
  Exp Mol Pathol.
  
  Volume: 94 Pages: 322-327
- DOI
  10.1016/j.yexmp.2012.10.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J02959, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24590449, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24791467, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115
[Journal Article] AKR1B10, a transcriptional target of p53, is downregulated in colorectal cancers associated with poor prognosis2013
- Author(s)
  Ohashi T et al.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 11 Pages: 1554-1163
- DOI
  10.1158/1541-7786.mcr-13-0330-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PUBLICLY-25134715, KAKENHI-PROJECT-25430115, KAKENHI-PROJECT-25460929
[Journal Article] Genome-wide profiling of chromatin signatures reveals epigenetic regulation of MicroRNA genes in colorectal cancer2012
- Author(s)
  Suzuki H
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 5646-5658
- DOI
  10.1158/0008-5472.can-11-1076
- NAID
  130004436468
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300320, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] Aberrant methylation of RASGRF1 is associated with an epigenetic field defect and increased risk of gastric cancer.2012
- Author(s)
  Takamaru H, Yamamoto E, Suzuki H.
- Journal Title
  
  Cancer Prev Ther (Phila)
  
  Volume: 5(10) Pages: 1203-12
- DOI
  10.1158/1940-6207.capr-12-0056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
[Journal Article] CLCA2, a target of the p53 family, negatively regulates cancer cell migration and invasion2012
- Author(s)
  Sasaki Y, Sugisaka J, Maruyama R, Sugisaka J, Tamura M, Sugisaka J, Suzuki H, Idogawa M, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Biology Therapy
  
  Volume: 13 Pages: 1512-1521
- DOI
  10.4161/cbt.22280
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] CHFR Protein Regulates Mitotic Checkpoint by Targeting PARP-1 Protein for Ubiquitination and Degradation2012
- Author(s)
  Kashima, L., Idogawa, M., Mita, H., Shitashige, M., Yamada, T., Ogi, K., Suzuki, H., Toyota, M., Ariga, H., Sasaki, Y., Tokino, T.
- Journal Title
  
  J Biol Chem.
  
  Volume: 287 Pages: 12975-12984
- DOI
  10.1074/jbc.m111.321828
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390014, KAKENHI-PROJECT-22790654, KAKENHI-PROJECT-22791293, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] Epigenetic alteration of DNA in mucosal wash fluid predicts invasiveness of colorectal tumors.2012
- Author(s)
  Seiko Kamimae
- Journal Title
  
  Cancer Prev Res(Phila)
  
  Volume: 4 Pages: 674-683
- DOI
  10.1158/1940-6207.capr-10-0214
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] Heat shock enhances the expression of cytotoxic granule proteins and augments the activities of tumor-associated antigen-specific cytotoxic T lymphocytes.2012
- Author(s)
  Takahashi A, Torigoe T, Tamura Y, Kanaseki T, Tsukahara T, Sasaki Y, Kameshima H, Tsuruma T, Hirata K, Tokino T, Hirohashi Y, Sato N
- Journal Title
  
  Cell Stress Chaperones.
  
  Volume: 17 Pages: 757-63
- DOI
  10.1007/s12192-012-0348-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590427, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24590448, KAKENHI-PROJECT-24659165, KAKENHI-PROJECT-24659592, KAKENHI-PROJECT-24791467
[Journal Article] Upregulation of miR-196a and HOTAIR drive malignant character in gastrointestinal stromal tumors.2012
- Author(s)
  Takeshi Niinuma
- Journal Title
  
  Cancer Research
  
  Volume: 72 Pages: 1126-1136
- DOI
  10.1158/0008-5472.can-11-1803
- NAID
  10031131121
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23300366, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659400, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24650632
[Journal Article] Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma.2012
- Author(s)
  Aoki Y, Nojima M, Suzuki H, Yasui H, Maruyama R, Yamamoto E, Ashida M, Itagaki M, Asaoku H, Ikeda H, Hayashi T, Imai K, Mori M, Tokino T, Ishida T, Toyota M, Shinomura Y
- Journal Title
  
  Genome Med.
  
  Volume: (印刷中)
- DOI
  10.1186/gm402
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-24591402
[Journal Article] A novel approach to cancer treatment using structural hybrids of the p53 gene family2012
- Author(s)
  Sasaki Y, Oshima Y, Koyama R, Kashima L, Idogawa M, Yamashita T, Toyota M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Cancer Gene Therapy
  
  Volume: 19 Pages: 749-56
- DOI
  10.1038/cgt.2012.51
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] Genome-wide analysis of DNA methylation identifies novel cancer-related genes in hepatocellular carcinoma2012
- Author(s)
  Shitani M, Sasaki S, Akutsu N, Takagi H, Suzuki H, Nojima M, Yamamoto H, Tokino T, Hirata K, Imai K, Toyota M, Shinomura Y
- Journal Title
  
  Tumor Biol
  
  Volume: 33 Pages: 1307-1317
- DOI
  10.1007/s13277-012-0378-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23659658
[Journal Article] Molecular dissection of premalignant colorectal lesions reveals early onset of the CpG island methylator phenotype.2012
- Author(s)
  Yamamoto E, Suzuki H, Yamano HO
- Journal Title
  
  American Journal of Pathology
  
  Volume: 181(5) Pages: 1847-1861
- DOI
  10.1016/j.ajpath.2012.08.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590317, KAKENHI-PROJECT-22790655, KAKENHI-PROJECT-23240129, KAKENHI-PROJECT-23390200, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658, KAKENHI-PROJECT-23791283, KAKENHI-PROJECT-24650632
[Journal Article] Cysteine-rich intestinal protein 2(CRIP2) acts as a repressor of NF-{ kappa} B-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis2011
- Author(s)
  Cheung, K.L., 7名略, Suzuki, T., 4名略
- Journal Title
  
  Pros Natl Acad Sci US
  
  Volume: 108 Pages: 8390-8395
- DOI
  10.1073/pnas.1101747108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22659011, KAKENHI-PROJECT-22791293, KAKENHI-PUBLICLY-23113701, KAKENHI-PROJECT-23390017, KAKENHI-PROJECT-23659658
[Journal Article] Negative regulation of hepatoma-derived growth factor by p532011
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Yokota I, Koyama R, Kusano M, Suzuki H, Fujita M, Maruyama R, Toyota M, Saito T, Tokino T
- Journal Title
  
  Cancer Research
  
  Volume: 71 Pages: 7038-47
- DOI
  10.1158/0008-5472.can-11-1053
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21592141, KAKENHI-PROJECT-22790654, KAKENHI-PROJECT-23501261, KAKENHI-PROJECT-23590920, KAKENHI-PROJECT-23659658
[Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
- Journal Title
  
  Carcinogenesis Vol.31, No.3
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] DNA methylation of interferon regulatory factors in gastric cancer and noncancerous gastric mucosae.2010
- Author(s)
  Yamashita M, Toyota M, Suzuki H, Nojima M, Yamamoto E, Kamimae S, Watanabe Y, Kai M, Akashi H, Maruyama R, Sasaki Y, Yamano H, Sugai T, Shinomura Y, Imai K, Tokino T, Itoh F
- Journal Title
  
  Cancer Sci Vol.101, No.7
  
  Pages: 1708-1716
- NAID
  10026594987
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Identification and characterization of early growth response 2, a zinc-finger transcription factor, as a p53-regulated proapoptotic gene.2010
- Author(s)
  Yokota I, Sasaki Y, Kashima L, Idogawa M, Tokino T
- Journal Title
  
  Int J Oncology Vol.37, No.6
  
  Pages: 1407-1416
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.2010
- Author(s)
  Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
- Journal Title
  
  Breast Cancer Res Treat Vol.122, No.3
  
  Pages: 699-710
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] IGFBP7 is a p53 responsive gene specifically silenced in colorectal cancer with CpG island methylator phenotype.2010
- Author(s)
  Suzuki H, Igarashi S, Nojima M, Maruyama R, Yamamoto E, Kai M, Akashi H, Watanabe Y, Yamamoto H, Sasaki Y, Itoh F, Imai K, Sugai T, Shen L, Issa J-P J, Shinomura Y, Tokino T, Toyota M
- Journal Title
  
  Carcinogenesis 31(3)
  
  Pages: 342-349
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] A novel correlation between LINE-1 hypomethylation and the malignancy of gastrointesrinal stromal tumors.2010
- Author(s)
  Igarashi S, Suzuki H, Niinuma T, Nojima M, Iwaki H, Nobuoka T, Nishida T, Miyazaki Y, Takamaru H, Yamamoto E, Yamamoto H, Tokino T, Hasegawa T, Hirata K, Imai K, Toyota M, Shinomura Y
- Journal Title
  
  Clin Cancer Res Vol.16, No.21
  
  Pages: 5114-5123
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] A novel biomarker for cervical cancer.2009
- Author(s)
  Tokino, Takashi
- Journal Title
  
  Cancer Biology Therapy VOL.8
  
  Pages: 1154-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] A novel biomarker for cervical cancer2009
- Author(s)
  Tokino, Takashi
- Journal Title
  
  Cancer Biology Therapy VOL.8
  
  Pages: 1154-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21659323
[Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.2009
- Author(s)
  Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Clin Cancer Res Vol.15, No.11
  
  Pages: 3725-3732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009
- Author(s)
  Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  J Biol Chem Vol.284, No.2
  
  Pages: 872-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma.2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H, Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
- Journal Title
  
  Clinical Cancer Research 15(13)
  
  Pages: 4356-4364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Genomic Screening for genes silenced by DNA methylation revealed an association between RASD1 inactivation and dexamethasone resistence in multiple myeloma.2009
- Author(s)
  Nojima M, Maruyama R, Yasui H, Suzuki H,Maruyama Y, Tarasawa I, Sasaki Y, Asaoku H, Sakai H, Hayashi T, Mori M, Imai K, Tokino T, Ishida T, Toyota M, Shinomura Y
- Journal Title
  
  Clin Cancer Res1 Vol.15, No.13
  
  Pages: 4356-4364
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells.2009
- Author(s)
  Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Clinical Cancer Research 15(11)
  
  Pages: 3725-3732
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] A novel biomarker for cervical cancer.2009
- Author(s)
  Tokino T
- Journal Title
  
  Cancer Biology Therapy 8(12)
  
  Pages: 1154-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Cancer epigenomics : Implications of DNA methylation in personalized cancer therapy.2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Sci Vol.100, No.5
  
  Pages: 787-791
- NAID
  10025145027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] A novel biomarker for cervical cancer.2009
- Author(s)
  Tokino T
- Journal Title
  
  Cancer Biol Ther Vol.8, No.12
  
  Pages: 1154-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] p53 family members regulate the expression of the apolipoprotein D gene.2009
- Author(s)
  Sasaki Y, Negishi H, Koyama R, Anbo N, Ohori K, Idogawa M, Mita H, Toyota M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  J Biol Chem 284(2)
  
  Pages: 872-883
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.2009
- Author(s)
  Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
- Journal Title
  
  Int J Cancer Vol.124, No.11
  
  Pages: 2607-2615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers : involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.2009
- Author(s)
  Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  BMC Cancer Vol.9, No.198(on line)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2009
- Author(s)
  Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
- Journal Title
  
  Oncogene 28(29)
  
  Pages: 2643-2653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Overexpression of Aurora A by loss of CHFR gene expression increases the growth and survival of HTLV-1-infected T cells through enhanced NF-kappaB activity.2009
- Author(s)
  Tomita M, Toyota M, Ishikawa C, Nakazato T, Okudaira T, Matsuda T, Uchihara JN, Taira N, Ohshiro K, Senba M, Tanaka Y, Ohshima K, Saya H, Tokino T, Mori N
- Journal Title
  
  Int J Cancer 124(11)
  
  Pages: 2607-2615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] A novel method, digital genome scanning detects KRAS gene amplification in gastric cancers: involvement of overexpressed wild-type KRAS in downstream signaling and cancer cell growth.2009
- Author(s)
  Mita H, Toyota M, Aoki F, Akashi H, Maruyama R, Sasaki Y, Suzuki H, Idogawa M, Kashima L, Yanagihara K, Fujita M, Hosokawa M, Kusano M, Sabau SV, Tatsumi H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  BMC Cancer 9
  
  Pages: 198-198
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2009
- Author(s)
  Kashima L, Toyota M, Mita H, Suzuki H, Idogawa M, Ogi K, Sasaki Y, Tokino T
- Journal Title
  
  Oncogene Vol.28, No.29
  
  Pages: 2643-2653
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Cancer epigenomics: Implications of DNA methylation in personalized cancer therapy.2009
- Author(s)
  Toyota M, Suzuki H, Yamashita T, Hirata K, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Science 100(5)
  
  Pages: 787-791
- NAID
  10025145027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] A novel biomarker for cervical cancer2009
- Author(s)
  Tokino, Takashi
- Journal Title
  
  Cancer Biology Therapy VOL.8
  
  Pages: 1154-1155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y, Imai K, Toyota M
- Journal Title
  
  P h a r m a c o g e n o m i c s 9(12)
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  C a n c e r R e s e a r c h 68(11)
  
  Pages: 4124-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Arequirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.2008
- Author(s)
  Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
- Journal Title
  
  Cancer Res Vol.68, No.8
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.2008
- Author(s)
  Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
- Journal Title
  
  Int J Oncology Vol.32, No.6
  
  Pages: 1253-1261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev Vol.17, No.10
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] A requirment for DICER to maintain full promoter CpG island hypermethylation in human cancer cells.2008
- Author(s)
  Ting AH, Suzuki H, Cope L, Schuebel KE, Lee BH, Toyota M, Imai K, Shinomura Y, Tokino T, Baylin SB
- Journal Title
  
  C a n c e r R e s e a r h 68(8)
  
  Pages: 2570-2575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  Carcinogenesis Vol.29, No.7
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer.2008
- Author(s)
  Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
- Journal Title
  
  G a s t r o e n t e r o l o g y 135(1)
  
  Pages: 142-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobactor pylori-related enlarged-fold gastritis.2008
- Author(s)
  Yamamoto E, Toyota M, Suzuki H, Kondo Y, Sanomura T, Murayama Y, Ohe-Toyota M, Muruyama R, Nojima M, Ashisa M, Fujii K, Sasaki Y, Hayashi N, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  C a n c e r E p i d e m i o l B i o m a r k e r s P r e v 17(10)
  
  Pages: 2555-2564
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] DNA hypermethylation causes incomplete systhesis of carbohydrate determinants in gastrointestinal cancer.2008
- Author(s)
  Kawamura YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, Dohi T
- Journal Title
  
  Gastroenterology Vol.135, No.1
  
  Pages: 142-151
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirusmediated p53 family gene therapy in cancer models.2008
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  M o l e c u l a r C a n c e r T h e r a p e u t i c s 7(4)
  
  Pages: 779-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
- Journal Title
  
  J Gastroenterol Vol.43, No.5
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Cytoplasmic RASSF2A is a pro-appoptotic mediator whose expression is epigenetically silenced in gastric cancer.2008
- Author(s)
  Maruyama R, Akino K, Toyota M, Suzuki H, Imai T, Ohe-Toyota M, Yamamoto E, Nojima M, Fujikane, Sasaki Y, Yamashita T, Watanabe Y, Hiratsuka H, Hirata K, Itoh F, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  C a r c i n o g e n e s i s 29(7): 29(7)
  
  Pages: 1312-1318
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells.2008
- Author(s)
  Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
- Journal Title
  
  J H e p a t o b i l i a r y P a n c r e a t S u r g 15(3)
  
  Pages: 310-317
- NAID
  10024157037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008
- Author(s)
  Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Res Vol.6, No.3
  
  Pages: 395-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] The histone deacetylase inhibitor FK228 enhances adenovirus-mediated p53 family gene therapy in cancer models.2008
- Author(s)
  Sasaki Y, Negishi H, Idogawa M, Suzuki H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  Mol Cancer Ther Vol.7, No.4
  
  Pages: 779-787
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008
- Author(s)
  Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
- Journal Title
  
  C a n c e r S c i e n c e 99(5)
  
  Pages: 958-966
- NAID
  10024006089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Epigenetic inactivation of SFRP genes in oral squamous cell carcinoma.2008
- Author(s)
  Sogabe Y, Suzuki H, Toyata M, Ogi K, Imai T, Nojima M, Sasaki Y, Hiratsuka H, Tokino T
- Journal Title
  
  I n t J O n c o l o g y 32(6)
  
  Pages: 1253-1261
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008
- Author(s)
  Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
- Journal Title
  
  B r J C a n c e r 98(6)
  
  Pages: 1147-1156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Epigenetic silencing of microRNA-34b/c and BTG4 is associated with CpG island methylation in colorectal cancer.2008
- Author(s)
  Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K, Shinomura Y, Tokino T.
- Journal Title
  
  Cancer Res Vol.68, No.11
  
  Pages: 4124-4132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Frequent epigenetic inactivation of Wnt antagonist genes in breast cancer.2008
- Author(s)
  Suzuki H, Toyota M, Caraway H, Gabrielson E, Ohmura T, Fujikane T, Nishikawa N, Sogabe Y, Nojima M, Sonoda T, Mori M, Hirata K, Imai K, Shinomura Y, Baylin SB, Tokino T
- Journal Title
  
  Br J Cancer Vol.98, No.6
  
  Pages: 1147-1156
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Epigenetic inactivation of RASSF2 in oral squamous cell carcinoma.2008
- Author(s)
  Imai T, Toyota M, Suzuki H, Akino K, Ogi K, Sogabe Y, Kashima L, Maruyama R, Nojima M, Mita H, Sasaki Y, Itoh F, Imai K, Shinomura Y, Hiratsuka H, Tokino T
- Journal Title
  
  Cancer Sci Vol.99, No.5
  
  Pages: 958-966
- NAID
  10024006089
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] In vitro transformation of adult rat hepatic progenitor cells into pancreatic endocrine hormone-producing cells.2008
- Author(s)
  Kawasaki H, Mizuguchi T, Kikkawa Y, Oshima H, Sasaki Y, Tokino T, Kokai Y, Miyazaki J, Katsuramaki T, Mitaka T, Hirata K
- Journal Title
  
  J Hepatobiliary Pancreat Surg Vol.15, No.3
  
  Pages: 310-317
- NAID
  10024157037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Frequent epigenetic inactivation of SFRP genes in hepatocellular carcinoma.2008
- Author(s)
  Takagi H, Sasaki S, Suzuki H, Toyota M, Maruyama R, Nojima M, Yamamoto H, Omata M, Tokino T, Imai K, Shinomura Y
- Journal Title
  
  J G a s t r o e n t e r o l 43(5)
  
  Pages: 378-389
- NAID
  10021268741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] DNA methylation and cancer pathways in gastrointestinal tumors.2008
- Author(s)
  Suzuki H, Tokino T, Shinomura Y,Imai K, Toyota M
- Journal Title
  
  Pharmacogenomics Vol.9, No.12
  
  Pages: 1917-1928
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390519
[Journal Article] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008
- Author(s)
  Sasaki Y, Oshima Y, Koyama R, Maruyama R, Akashi H, Mita H, Toyota M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  M o l e c u l a r C a n c e r R e s 6(3)
  
  Pages: 395-406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate betacatenine and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling.2007
- Author(s)
  Idogawa M, Masutani M, Shitashige M, Honda K, Tokino T, Shinomura, Imai K, Hirohashi S, Yamada T
- Journal Title
  
  C a n c e r R e s e a r c h 67(3)
  
  Pages: 911-918
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Frequent epigenetic inactivation of DICKKOPF family genes in human gastrointestinal tumors.2007
- Author(s)
  Sato H, Suzuki H, Toyota M, Nojima M, Maruyama R, Sasaki S, Takagi H, Sogabe Y, Sasaki Y, Idogawa M, Sonoda T, Mori M, Imai K, Tokino T, Shinomura Y
- Journal Title
  
  C a r c i n o - g e n e s i s 28(12)
  
  Pages: 2459-2466
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Gene Amplification and Overexpression of PRDM14 in Breast Cancers.2007
- Author(s)
  Nishikawa N, Toyota M, Suzuki H, Honma T, Fujikane T, Ohmura T, Nishidate T, Ohe-Toyota M, Maruyama R, Sonoda T, Sasaki Y, Urano T, Imai K, Hirata K, Tokino T
- Journal Title
  
  C a n c e r R e s e a r c h 67(20)
  
  Pages: 9649-9657
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Identification of DFNA5 as a target of epigenetic inactivation in gastric cancer.2007
- Author(s)
  Akino K, Toyota M, Suzuki H, Imai T, Maruyama R, Kusano M, Nishikawa N, Watanabe Y, Sasaki Y, Abe T, Yamamoto E, Tarasawa I, Sonoda T, Mori M, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  C a n c e r S c i e n c e 98(1)
  
  Pages: 88-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Expression profiling of PRDM family genes identified PRDM5 as a target of epigenetic silencing in colorectal and gastric cancer.2007
- Author(s)
  Watanabe Y, Toyota M, Kondo Y, Suzuki H, Imai T, Ohe-Toyota M, Maruyama R, Nojima M, Sasaki Y, Sekido Y, Hiratsuka H, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  C l i n i c a l C a n c e r R e s 13(16)
  
  Pages: 4786-4794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Frequent epigenetic inactivation of SFRP genes and constitutive activation of Wnt signaling in gastric cancer.2007
- Author(s)
  Nojima M, Suzuki H, Toyota M, Watanabe Y, Maruyama R, Sasaki S, Sasaki Y, Mita H, Nishikawa N, Yamaguchi K, Hirata K, Itoh F, Tokino T, Mori M, Imai K, Shinomura Y
- Journal Title
  
  O n c o g e n e 26(32)
  
  Pages: 4699-4713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Antitumor effect of adenovirusmediated p53 family gene transfer on osteosarcoma cell lines.2007
- Author(s)
  Oshima Y, Sasaki Y, Negishi H, Toyota M, Yamashita T, Wada T, Nagoya S, Kawaguchi S, Yamashita T, Tokino T
- Journal Title
  
  C a n c e r B i o l o g y T h e r a p y 6(7)
  
  Pages: 1058-1066
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.2006
- Author(s)
  Kobayashi T, Sasaki Y, Oshima Y, Yamamoto H, Mita H, Suzuki H, Toyota Y, Tokino T, Itoh F, Imai K, Shinomura Y
- Journal Title
  
  I n t J M o l M e d 18(1)
  
  Pages: 161-170
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Implications for gene therapy treatment of human glioblastomas.2006
- Author(s)
  Kang X, Xiao X, Harata M, Bai Y, Nakazaki Y, Soda Y, Kurita R, Tanaka T, Komine F, Izawa K, Kunisaki R, Setoyama M, Nishimori H, Natsume A, Sunamura M, Lozonshi L, Saitoh I, Tokino T, Asano S, Nakamura Y, Tani K: Antiangiogenic potency of BAI1 in vivo
- Journal Title
  
  C a n c e r G e n e T h e r a p y 13(4)
  
  Pages: 385-392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Epigenetic inactivation of the candidate tumor suppressor gene HOXB13 in human renal cell carcinama.2006
- Author(s)
  Okuda H, Toyota M, Ishida W, Furihata M, Tsuchiya M, Kamada M, Tokino T, Shuinn T
- Journal Title
  
  O n c o g e n e 25(12)
  
  Pages: 1733-1742
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Unique domain functions of p63 isotypes that differentially regulate distinct aspects of epidermal homeostasis2006
- Author(s)
  King KE, Ponnamperuma RM, Gerdes MJ, Tokino T, Yamashita T, Baker CC, Weinberg WC
- Journal Title
  
  C a r c i n o g e n e s i s 27(1)
  
  Pages: 53-63
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Epigenetic inactivation of TCF2 in ovarian cancer and various cancer cell lines.2006
- Author(s)
  Terasawa K, Toyota M, Sagae S, Ogi K, Suzuki H, Sonoda T, Akino K, Maruyama R, Nishikawa N, Imai K, Shinohara Y, Saito T, Tokino T
- Journal Title
  
  B r J C a n c e r 94(6)
  
  Pages: 914-921
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Genetic, epigenetic and clinicopathological features of gastric cancers with CpG island methylator phenotype and association to Epstein-Barr virus.2006
- Author(s)
  Kusano M, Toyota M, Suzuki H, Akino K, Aoki F, Fujita M, Hosokawa M, Shinomura Y, Imai K, Tokino T
- Journal Title
  
  C a n c e r 106(7)
  
  Pages: 1467-1479
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Comparative genome analysis identifies the vitamin D receptor gene as a direct target of p53-mediated transcriptional activation.2006
- Author(s)
  Maruyama R, Aoki F, Toyota M, Sasaki Y, Akashi H, Mita H, Suzuki H, Akino K, Ohe-Toyota M, Maruyama Y, Tatsumi H, Imai K, Shinomura Y, Tokino T
- Journal Title
  
  C a n c e r R e s e a r c h 66(9)
  
  Pages: 4574-83
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] The role of T-fimbrin in the response to DNA damage: Silencing of T-fimbrin by small interfering RNA sensitizes human liver cancer cells to DNA-damaging agents.2005
- Author(s)
  Ikeda H, Sasaki Y, Kobayashi T, Suzuki H, Mita H, Toyota M, Itoh F, Shinomura Y, Tokino T, Imai K
- Journal Title
  
  I n t J O n c o l 27(4)
  
  Pages: 933-40
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] The Ras effector RASSF2 is a novel tumor suppressor gene in human colorectal cancer.2005
- Author(s)
  Akino K, Toyota M, Suzuki H, Mita H, Sasaki Y, Ohe-Toyota M, Issa J-P J, Hinoda Y, Imai K, Tokino T
- Journal Title
  
  G a s t r o e n t e r o l o g y 129(1)
  
  Pages: 156-169
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours.2005
- Author(s)
  Murai M, Toyota M, Satoh A, Suzuki H, Akino K, Mita H, Sasaki Y, Ishida T, Shen L, Garcia-Manero G, Issa JP, Hinoda Y, Tokino T, Imai K
- Journal Title
  
  B r J C a n c e r 92(6)
  
  Pages: 1165-1172
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Small interfering RNA-induced CHFR silencing sensitizes oral squamous cell cancer cells to microtuble inhibitors.2005
- Author(s)
  Ogi K, Toyota M, Mita H, Satoh A, Kashima L, Sasaki Y, Suzuki H, Akino K, Nishikawa N, Shinomura Y, Imai K, Hiratsuka H, Tokino T
- Journal Title
  
  C a n c e r B i o l o g y T h e r a p y 4(7)
  
  Pages: 773-780
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation.2005
- Author(s)
  Simbulan-Rosethal CM, Trabosh V, Velarde A, Chou FP, Daher A, Tenzin F, Tokino T, Rosenthal DS
- Journal Title
  
  O n c o g e n e 24(35)
  
  Pages: 5443-5458
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Identification of laminin b3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumors.2005
- Author(s)
  Irifune H, Nishimori H, Watanabe G, Yoshida K, Ikeda T, Matsui C, Morohashi M, Kawaguchi S, Nagoya S, Wada T, Yamashita T, Nakamura Y, Tokino T
- Journal Title
  
  C a n c e r B i o l o g y T h e r a p y 4(4)
  
  Pages: 449-455
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Tight junction proteinMAGi-1 is up-regulated by tranfection with connexin 32 in an immortalized mouse hepatic cell line: cDNA microarray analysis.2005
- Author(s)
  Murata M, Kojima T, Yamamoto T, Go M, Takano K, Chiba H, Tokino T, Sawada N
- Journal Title
  
  C e l l T i s s u e R e s 319(2)
  
  Pages: 341-347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Abnormal beta-catenin expression in oral cancer with no gene mutation: correlation with expression of cyclin D1 and epidermal growth factor receptor, Ki-67 labeling index, and clinicopathological features.2005
- Author(s)
  Odajima T, Sasaki Y, Tanaka N, Kato-Mori Y, Asanuma H, Ikeda T, Satoh M, Hiratsuka H, Tokino T, Sawada N
- Journal Title
  
  H u m P a t h o l 36(3)
  
  Pages: 234-241
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Enhanced Bax in oral SCC in relation to antitumor effects of chemotherapy.2005
- Author(s)
  Takemura K, Noguchi M, Ogi K, Tokino T, Kubota H, Miyazaki A, Kohama G, Horatsuka H
- Journal Title
  
  J O r a l P a t h o l M e d 34(2)
  
  Pages: 93-99
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Identification of pigment epithelium derived factor as a direct target of the p53 family member genes.2005
- Author(s)
  Sasaki Y, Naishiro Y, Oshima Y, Imai K, Nakamura Y, Tokino T
- Journal Title
  
  O n c o g e n e 24(32)
  
  Pages: 5131-5136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] A full genome scan for gastric cancer.2005
- Author(s)
  AokiM,YamamuraY,NoshiroH,SakaiK,YokotaJ,KohnoT,TokinoT,IshidaS,OhyamaS,NinomiyaI,UesakaK,KitajimaM,ShimadaS,MatsunoS,YanoM,HiratsukaM,SugimuraH,ItohF,MinamotoT,MaeharaY,TakenoshitaS,AikouT,KataiH,Yoshimura K, TakahashiT,AkagiK,SairenjiM,YamamotoK,SasazukiT
- Journal Title
  
  J M e d i c a l G e n e t i c s 42(1)
  
  Pages: 83-87
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Upregulation of BNIP3 by 5-aza-2 ' -deoxycytidine sensitizes pancreatic cancer cells to hypoxia-mediated cell death.2005
- Author(s)
  Abe T, Toyota M, Suzuki H, Murai M, Akino K, Ueno M, Nojima M, Yawata A, Miyakawa H, Suga T, Ito H, Endo T, Tokino T, Hinoda Y, Imai K
- Journal Title
  
  J G a s t r o e n t e r o l 40(5)
  
  Pages: 504-510
- NAID
  10015648191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Aberrant methylation and silencing of the BNIP3 gene in colorectal and gastric cancer.2005
- Author(s)
  Murai M, Toyota M, Suzuki H, Satoh A, Sasaki Y, Akino K, Ueno M, Takahashi F, Kusano M, Mita H, Yanagihara K, Endo T, Hinoda Y, Tokino T, Imai K
- Journal Title
  
  C l i n i c a l C a n c e r R e s 11(3)
  
  Pages: 1021-1027
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Dual roles of p53 in DNA binding.2004
- Author(s)
  Tokino T et al.
- Journal Title
  
  Cancer Biology Therapy 3-12
  
  Pages: 1322-1323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390597
[Journal Article] Dual roles of p53 in DNA binding.2004
- Author(s)
  Tokino T
- Journal Title
  
  Cancer Biology Therapy 3・12
  
  Pages: 1322-1323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16390597
[Journal Article] Dual roles of p53 in DNA binding.
- Author(s)
  Tokino T
- Journal Title
  
  Cancer Biology ＆ Therapy (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213115
[Journal Article] Genomic screening for genes upregulated by demethylation revealed novel targets of epigenetic silencing in breast cancer.
- Author(s)
  Fujikane T, Nishikawa N, Toyota M, Suzuki H, Nojima M, Maruyama R, Ashida M, Ohe-Toyota M, Kai M, Nishidate T, Sasaki Y, Ohmura T, Hirata K, Tokino T
- Journal Title
  
  Breast Cancer Res Treat (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013072
[Journal Article] Dual roles of p53 in DNA binding.
- Author(s)
  Tokino T
- Journal Title
  
  Cancer Biology & Therapy (発表予定)
- Data Source
  KAKENHI-PROJECT-16390597
[Journal Article] Dual roles of p53 in DNA binding.
- Author(s)
  Tokino T
- Journal Title
  
  Cancer Biology & Therapy (発表予定)
- Data Source
  KAKENHI-PROJECT-12213115
[Patent] p53キメラ遺伝子を含む抗腫瘍剤2012
- Inventor(s)
  時野隆至
- Industrial Property Rights Holder
  札幌医科大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2012-187062
- Filing Date
  2012-08-27
- Data Source
  KAKENHI-PROJECT-23659658
[Patent] p53キメラ遺伝子を含む抗腫〓剤2012
- Inventor(s)
  時野隆至、佐々木泰史、井戸川雅史
- Industrial Property Rights Holder
  札幌医科大学
- Filing Date
  2012-08-27
- Data Source
  KAKENHI-PROJECT-23659658
[Presentation] Targeted exome sequencing profiles genetic alterations in oral squamous cell carcinoma from Japanese patients.2019
- Author(s)
  Sasaki Y, Nakagaki T, Tamura M, Fukushima F, Ikeda H, Koyama R, Idogawa M, Tokino T
- Organizer
  American Association of Cancer Research (AACR) annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] The novel p53 family target BRMS1L suppresses cancer cell invasion and migration2019
- Author(s)
  Sasaki Y, Koyama R, Maruyama R, Tamura M, Idogawa M, Suzuki H, Tokino T
- Organizer
  11th AACR-JCA Joint International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR2019
- Author(s)
  Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Noriyuki Sasaki, Mizunori Yaegashi, Yuji Akiyama, Akira Sasaki, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
- Organizer
  アメリカ癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Amplicon-based targeted sequencing identifies promising markers in oral squamous cell carcinoma from Japanese patients.2019
- Author(s)
  Takashi Tokino, Takafumi Nakagaki, Masashi Idogawa, Yasushi Sasaki.
- Organizer
  11th AACR-JCA Joint International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Mutational Profiling of Japanese Cervical Cancer Patients Treated with Radiotherapy2019
- Author(s)
  Yuya Yoshimoto, Takahiro Oike, Yasushi Sasaki, Endang Nuryadi, Kazutoshi Murata, Takuya Kaminuma, Daisuke Irie, Daijiro Kobayashi, Tatsuya Ohno, Takashi Tokino, Takashi Nakano
- Organizer
  The 9th Annual Meeting of The International Society of Radiation Neurobiology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Epigenetic regulation of miR-200b is associated with cisplatin resistance in bladder cancer.2019
- Author(s)
  Shindo T, Niinuma T, Kitajima H, Kai M, Tokino T, Masumori N, Suzuki H.
- Organizer
  11th AACR-JCA Joint International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Patient-specific circulating tumor DNA monitoring using esophageal squamous cell cancer gene panel and digital PCR.2019
- Author(s)
  Iwaya T, Endo F, Sasaki Y, Sasaki N, Yaegashi M, Akiyama Y, Sasaki A, Masuda M, Yamada T, Tokino T, Nishizuka S.
- Organizer
  Amerian Association for Cancer Research (AACR)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] BRMSIL, a metastatic suppressor gene is transcriptionally regulated by p53.2019
- Author(s)
  Takashi Tokino, Ryota Koyama, Masashi Idogawa, Yasushi Sasaki.
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] DOT1L inhibition blocks multiple myeloma cell proliferation by suppressing IRF4-MYC signaling.2019
- Author(s)
  Ishiguro K, Kitajima H, Niinuma T, Ishida T, Maruyama R, Ikeda H, Yamamoto E, Kai M, Sasaki Y, Tokino T, Nakase H, Suzuki H.
- Organizer
  11th AACR-JCA Joint International Conference
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Patient-specific circulating tumor DNA monitoring using digital PCR in esophageal squamous cell cancer patients.2018
- Author(s)
  Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Mizunori Yaegashi, Kei Sato, Noriyuki Sasaki, Yuji Akiyama, Akira Sasaki, Mari Masuda, Takashi Tokino, Satoshi Nishizuka
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] 口腔扁平上皮癌のhotspot変異解析2018
- Author(s)
  佐々木泰史、中垣貴文、田村みゆき、井戸川雅史、荻和弘、平塚博義、時野隆至
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Therapeutic response monitoring using digital PCR for patient-specific circulating tumor DNA identified by an esophageal squamous cell carcinoma-specific sequencing panel.2018
- Author(s)
  Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Yuji Akiyama, Akira Sasaki, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
- Organizer
  米国臨床腫瘍学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] 口腔扁平上皮癌の全エクソン解析2017
- Author(s)
  佐々木泰史, 田村みゆき, 中垣貴文, 小山良太, 井戸川雅史, 荻和弘, 平塚博義, 仲瀬裕志, 時野隆至
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Exploitation of a liquid biopsy system using circulating tumor DNA in esophageal cancer patients2017
- Author(s)
  Takeshi Iwaya, Fumitaka Endo, Yasushi Sasaki, Mizunori Yaegashi, Takehiro Chiba, Yuji Akiyama, Mari Masuda, Tesshi Yamada, Takashi Tokino, Satoshi Nishizuka
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Profiling cancer-related gene alterations in Japanese multiple myeloma patients by targeted amplicon sequencing.2017
- Author(s)
  Fukushima H, Sasaki Y, Tamura M, Ikeda H, Ishiguro K, Tokino T.
- Organizer
  European Human Genetics Conference 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Targeted exome sequences of cancer-related genes in human cancers using amplicon sequencing.2017
- Author(s)
  Sasaki Y, Nakagaki T, Tamura M, Fukushima H, Ikeda H, Koyama R, Idogawa M, Tokino T
- Organizer
  American Association of Cancer Research(AACR, 米国癌学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Profiling cancer-related gene mutations in oral squamous cell carcinoma from Japanese patients by targeted amplicon sequencing2017
- Author(s)
  Sasaki Y, Nakagaki T, Tamura M, Kobashi K, Koyama R, Fukushima F, Idogawa M, Ogi K, Hiratsuka H, Tokino T
- Organizer
  The 12th International Workshop on Advanced Genomics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Mutation detection by target sequence analyses using tissue-specific panels in esophageal squamous cell carcinoma2017
- Author(s)
  Takeshi Iwaya, Fumitaka Endo, Kohei Kume, Yasushi Sasaki, Takashi Tokino, Satoshi Nishizuka
- Organizer
  アメリカ癌学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] Exome sequencing of cancer -related genes to identify genetic markers for sensitivity to cytotoxic anticancer drugs.2017
- Author(s)
  Udagawa C, Sasaki Y, Suemizu H, Ohnishi Y, Ohnishi H, Tokino T, Zembutsu H.
- Organizer
  American Association of Cancer Research(AACR, 米国癌学会)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06279
[Presentation] p53 downregulates CRKL oncogene through miR-200.2016
- Author(s)
  Tokino T, Tamura M, Idogawa M, Sasaki Y
- Organizer
  American Association of Cancer Research (AACR) annual meeting.
- Place of Presentation
  New Orleans Convention Center, USA
- Year and Date
  2016-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07122
[Presentation] p53 downregulates CRKL oncogene through miR-200.2016
- Author(s)
  Tokino T, Tamura M, Idogawa M, Sasaki Y
- Organizer
  American Association of Cancer Research (AACR) annuak meeting.
- Place of Presentation
  New Orleans Convention Center, USA
- Year and Date
  2016-04-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] p53経路と発がん2016
- Author(s)
  時野隆至
- Organizer
  日本癌学会
- Place of Presentation
  パシフィコ横浜，神奈川県横浜市
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] p53ネットワークとがん：最近の話題2015
- Author(s)
  時野隆至
- Organizer
  日本癌学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Invited
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] Genome-wide RNAi screening to identify shRNA that enhance p53-related apoptosis in human cancer cells2015
- Author(s)
  Tokino T
- Organizer
  SNUCRI Cancer Symposium
- Place of Presentation
  Hwasun, Korea
- Year and Date
  2015-04-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] Genome-based personalized medicine in oncology.2014
- Author(s)
  Tokino T
- Organizer
  The 18th International Congress of Personalized Medicine.
- Place of Presentation
  札幌
- Year and Date
  2014-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.2014
- Author(s)
  Tokino T, Tamura M, Idogawa M, Sasaki Y
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting.
- Place of Presentation
  San Diego, USA.
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] Genome-based personalized medicine in oncology2014
- Author(s)
  Tokino T
- Organizer
  The 18th International Congress of Personalized Medicine
- Place of Presentation
  札幌コンベンションセンター(北海道・札幌市)
- Year and Date
  2014-06-14
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Identification and analysis of large intergenic non-coding RNAs regulated by p53 family members through a genome-wide analysis of p53 binding sites.2014
- Author(s)
  Idogawa M, Ohashi T, Sasaki Y, Tokino T
- Organizer
  16th International p53 Workshop.
- Place of Presentation
  Stockholm, Sweden.
- Year and Date
  2014-06-17
- Data Source
  KAKENHI-PUBLICLY-25134715
[Presentation] p53 family network and tumor suppression.2014
- Author(s)
  Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
- Organizer
  The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
- Place of Presentation
  Zhangjiajie, China.
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PUBLICLY-25134715
[Presentation] Forkhead transcription factor FOXFI is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness2014
- Author(s)
  Tokino T, Tamura M, Idogawa M, Sasaki Y
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting
- Place of Presentation
  San Diego, U.S.A.
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] Genome-based personalized medicine in oncology.2014
- Author(s)
  Tokino T
- Organizer
  The 18th International Congress of Personalized Medicine.
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2014-06-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25134715
[Presentation] Forkhead transcription factor FOXF1 is a novel target gene of the p53 family and regulates cancer cell migration and invasiveness.2014
- Author(s)
  Tokino T, Tamura M, Idogawa M, Sasaki Y
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting.
- Place of Presentation
  San Diego, USA.
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PUBLICLY-25134715
[Presentation] p53 family network and tumor suppression.2014
- Author(s)
  Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
- Organizer
  The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
- Place of Presentation
  Zhangjiajie, China.
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-25430115
[Presentation] p53 family network and tumor suppression2014
- Author(s)
  Sasaki Y, Tamura, M, Takeda K, Idogawa M, Maruyama R, Suzuki H, Shinomura Y, Tokino T
- Organizer
  The 3rd International Symposium on Genetic Regulation and Targeted Therapy of Cancer and 5th Symposium of A3 Foresight Program
- Place of Presentation
  Zhangjiajie, China
- Year and Date
  2014-06-13
- Data Source
  KAKENHI-PROJECT-221S0001
[Presentation] p53研究の新展開2012
- Author(s)
  時野　隆至
- Organizer
  第７１回日本癌学会学術総会
- Place of Presentation
  札幌市教育文化会館（札幌）
- Data Source
  KAKENHI-PROJECT-23659658
[Presentation] Identification of novel p53 target genes by ChIP-Seq and mRNA expression analysis combined with genome-wide p53-binding motif analysis in silico.2011
- Author(s)
  Idogawa M, (Tokino T)
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23659658
[Presentation] Apoptosis induction in cancer cells by the simultaneous transduction of p53 and artificial miRNAs based on the screening of genome-wide shRNA library2011
- Author(s)
  Idogawa M, (Tokino T)
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23659658
[Presentation] A comprehensive analysis to screen for epigenetically silenced miRNA genes in colorectal cancer2011
- Author(s)
  Suzuki H, (Tokino T)
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23659658
[Presentation] The functional relationship between CHFR and PARP-1 controls the antephase checkpoint and tumor development2011
- Author(s)
  Kashima L, (Tokino T)
- Organizer
  American Association of Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Orlando, USA
- Year and Date
  2011-04-03
- Data Source
  KAKENHI-PROJECT-23659658
[Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2010
- Author(s)
  Tokino T, Kashima L, Toyota M, Sasaki Y.
- Organizer
  101th American Association of Cancer Research (AACR) Annual Meeting
- Place of Presentation
  Washington DC, USA.
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2010
- Author(s)
  Tokino, Takashi, et al
- Organizer
  米国癌学会年会
- Place of Presentation
  Convention Center, Wasgington, DC(米国)
- Year and Date
  2010-04-20
- Data Source
  KAKENHI-PROJECT-20390519
[Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer.2010
- Author(s)
  Tokino T, Idogawa M, Sasaki Y.
- Organizer
  8th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association.
- Place of Presentation
  Hawaii, USA.
- Year and Date
  2010-02-09
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer2010
- Author(s)
  Tokino, Takashi
- Organizer
  8th Joint Conference of AACR and JCA
- Place of Presentation
  Hilton Waikoloa Village(米国)
- Year and Date
  2010-02-09
- Data Source
  KAKENHI-PROJECT-20390519
[Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer2010
- Author(s)
  Tokino, Takashi
- Organizer
  8th Joint Conference of AACR and JCA
- Place of Presentation
  Hilton Waikoloa Village(米国)
- Year and Date
  2010-02-09
- Data Source
  KAKENHI-PROJECT-21659323
[Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer.2010
- Author(s)
  Tokino, Takashi
- Organizer
  8th Joint Conference of AACR and JCA
- Place of Presentation
  Hilton Waikoloa Village(米国)
- Year and Date
  2010-02-09
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] A single adenovirus expressing p53 protein and p21-targeting artificial microRNAs improves therapeutic outcome in cancer.2010
- Author(s)
  Tokino T, Idogawa M, Sasaki Y.
- Organizer
  8th AACR-JCA Joint International Conference.
- Place of Presentation
  Waikoloa, Hawaii
- Data Source
  KAKENHI-PROJECT-20390519
[Presentation] CHFR, a potential tumor suppressor, downregulates interleukin-8 via inhibition of NF-kB.2010
- Author(s)
  Tokino T, Kashima L, Toyota M, Sasaki Y.
- Organizer
  101st American Association of Cancer Research (AACR) annual meeting.
- Place of Presentation
  Washington D.C
- Data Source
  KAKENHI-PROJECT-20390519
[Presentation] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008
- Author(s)
  Tokino T, Sasaki Y.
- Organizer
  99th American Association of Cancer Research (AACR) Annual Meeting.
- Place of Presentation
  San Diego, USA.
- Year and Date
  2008-04-14
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] Identification of flotillin-2, a major protein on lipid rafts, as a novel target of the p53 family members.2008
- Author(s)
  Tokino T, Sasaki Y.
- Organizer
  American Association of Cancer Research (AACR) Annual meeting.
- Place of Presentation
  San Diego, USA
- Data Source
  KAKENHI-PROJECT-20390519
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2008
- Author(s)
  時野隆至
- Organizer
  米国癌学会年会
- Place of Presentation
  米国ロサンゼルス
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-19659344
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2008
- Author(s)
  時野隆至
- Organizer
  米国癌学会年会
- Place of Presentation
  米国ロサンゼルス
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-20390519
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2008
- Author(s)
  時野隆至
- Organizer
  米国癌学会年会
- Place of Presentation
  米国ロサンゼルス
- Year and Date
  2008-04-17
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007
- Author(s)
  Takashi, Tokino, et. al.
- Organizer
  AACR Annual Meeting
- Place of Presentation
  Los Angeles, CA
- Year and Date
  2007-04-17
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390545
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007
- Author(s)
  Tokino T, Oshima Y, Yamashita T, Sasaki Y.
- Organizer
  98th American Association of Cancer Research (AACR) Annual Meeting.
- Place of Presentation
  Los Angeles, USA.
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007
- Author(s)
  Takashi Tokino
- Organizer
  米国癌学会年会
- Place of Presentation
  ロサンゼルス
- Year and Date
  2007-04-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390545
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007
- Author(s)
  時野隆至
- Organizer
  米国癌学会
- Place of Presentation
  米国ロサンゼルス
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-19659344
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines2007
- Author(s)
  時野隆至
- Organizer
  米国癌学会
- Place of Presentation
  米国ロサンゼルス
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-17013702
[Presentation] Antitumor effect of adenovirus-mediated p53 family gene transfer on osteosarcoma cell lines.2007
- Author(s)
  時野隆至
- Organizer
  米国癌学会(American Association of Cancer Research)
- Place of Presentation
  米国ロサンゼルス
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-18390545
[Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes.2006
- Author(s)
  Tokino T, Sasaki Y.
- Organizer
  97th American Association of Cancer Research (AACR) Annual Meeting.
- Place of Presentation
  Washington DC, USA.
- Year and Date
  2006-04-03
- Data Source
  KAKENHI-PROJECT-17013072
[Presentation] Pigment epithelium derived factor as a direct target of the p53 family member genes2006
- Author(s)
  Takashi Tokino
- Organizer
  米国癌学会年会
- Place of Presentation
  ワシントンDC
- Year and Date
  2006-04-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390545
[Presentation] Identification of laminin beta 3 isoforms downstream of EWS-ETS fusion genes in Ewing family tumor.2005
- Author(s)
  Tokino T, Irifune H, Sasaki Y, Yoshida K, Kawaguchi S, Wada T, Yamashita T.
- Organizer
  96th American Association of Cancer Research (AACR) Annual Meeting.
- Place of Presentation
  Anaheim, USA.
- Year and Date
  2005-04-19
- Data Source
  KAKENHI-PROJECT-17013072

1. FURUHATA Tomohisa (80359992)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. HIRATSUKA Hiroyoshi (50165180)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
3. 中村祐輔 (70217909)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
4. OGI Kazuhiro (40433114)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
5. SASAKI Yasushi (70322328)

# of Collaborated Projects: 3 results

# of Collaborated Products: 43 results
6. SAGAE Satoru (00187056)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. TSUCHIYA Eiju (00072314)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TAKAHASHI Takashi (50231395)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
9. ISHIKAWA Fuyuki (30184493)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HINO Okio (90127910)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
11. MIYAZONO Kohei (90209908)

# of Collaborated Projects: 2 results

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12. KUDO Ryuichi (70045409)

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13. 佐藤孝明 (30225958)

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# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
17. INOUE Junichiro (70176428)

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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19. YAMAMURA Kenichi (90115197)

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20. ARAKI Kimi (90211705)

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35. TANAKA Hideo (60470168)

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36. WAKAI Kenji (50270989)

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37. MIKAMI Haruo (10332355)

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38. SUZUKI Sadao (20226509)

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39. MIURA Katsuyuki (90257452)

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42. TANAKA Keitaro (50217022)

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43. TAKEZAKI Toshiro (50227013)

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45. NAITO Mariko (10378010)

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48. KURIKI Kiyonori (20543705)

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49. TAMAKAOSHI Akiko (90236737)

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55. SUGIMURA Haruhiko (00196742)

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56. TSUGANE Shoichiro (40179982)

# of Collaborated Projects: 1 results

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57. NAKATOCHI Masahiro (10559983)

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198. 藤原義之

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199. 泉本修一

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200. KAMAGATA Kiyoto

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201. INABA Kenji

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202. YAMAMOTO Eiichiro

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203. NAKASE Hiroshi

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206. KOBAYASHI Junichi

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207. YAMANO Hiro-o

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208. SUGAI Tamotsu

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210. Takashima Yasuo

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211. Iwadate Yasuo

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212. 秋山好光

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213. 田中真二

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214. 島田周

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215. 土屋輝一郎

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216. 深町博史

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217. 鈴木利治

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218. 鹿島理沙

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219. 奥村正樹

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220. 高橋聡

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228. 西山廣陽

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229. 宮崎晃亘

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231. 新沼猛

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239. 野田真永

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240. 中野隆史

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241. 久保亘輝

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242. 田村保明

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# of Collaborated Products: 2 results
243. 佐藤昇志

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# of Collaborated Products: 2 results
244. 鳥越俊彦

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# of Collaborated Products: 1 results
245. 平田公一

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# of Collaborated Products: 1 results
246. 高橋あかり

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
247. 眞杉洋平

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# of Collaborated Products: 1 results
248. 山中龍也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
249. 高島康郎

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# of Collaborated Products: 1 results
250. 平川隆史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
251. 柴田淳史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
252. 西山直隆

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# of Collaborated Products: 1 results
253. 進藤哲哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
254. 佐藤亜紀子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
255. 斉藤豪

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
256. 鈴木孝浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

TOKINO Takashi 時野 隆至

時野 隆志 トキノ タカシ

時野 隆臣 トキノ タカオミ

時野 隆至 トキノ タカシ

Research Projects

Research Products

Co-Researchers

p53 pathway and its potential targeted therapeutic approachPrincipal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

A better understanding of p53 network for cancer therapyPrincipal Investigator

Principal Investigator

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Principal Investigator

Principal Investigator(Support)

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Research Institution

バイオインフォマティクスを活用したp53ネットワーク探索と癌治療への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

New insights into p53 signaling regulation to cure cancerPrincipal Investigator

Principal Investigator

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Research Institution

High-throughput screening for peptides that inhibit the interaction or MDM4 with p53Principal Investigator

Principal Investigator

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Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

RNA干渉技術を駆使してアポトーシス誘導シグナルを増強した遺伝子治療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Principal Investigator

Project Period (FY)

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Functional analysis of CHFR: Diagnostic and therapeutic application for oral squamous cell cancerPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

デジタル ゲノム スキャニング法の開発と胃癌関連遺伝子探索への応用Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Diagnostic and therapeutic application of cell-cycle checkpoint genes for oral squamous cell cancer.Principal Investigator

Principal Investigator

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Research Field

Research Institution

p53 family : function and cancer therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

TOKINO Takashi 時野隆至

時野隆志トキノタカシ

時野隆臣トキノタカオミ

時野隆至トキノタカシ

デジタルゲノムスキャニング法の開発と胃癌関連遺伝子探索への応用Principal Investigator