Saya Hideyuki 佐谷秀行

… Alternative Names

Researcher Number	80264282
Other IDs	https://orcid.org/0000-0001-6610-1902
External Links
Affiliation (Current)	2022: 慶應義塾大学, 医学部(信濃町), 名誉教授 2022: 藤田医科大学, がん医療研究センター, センター長
Affiliation (based on the past Project Information) *help	2017 – 2021: 慶應義塾大学, 医学部(信濃町), 教授 2017: 慶応大学, 医学部, 教授 2017: 慶應義塾大学, 医学部, 教授 2006 – 2015: Keio University, School of Medicine, Professor, 医学部, 教授 2010 – 2011: 慶応義塾大学, 医学部, 教授 … More
Review Section/Research Field	Principal Investigator Cerebral neurosurgery / Cerebral neurosurgery / Biological Sciences / Pathological medical chemistry / Medium-sized Section 50:Oncology and related fields / Pathological medical chemistry / Experimental pathology / Tumor biology / Tumor biology / Neurosurgery … More Except Principal Investigator … More
Keywords	Principal Investigator 癌 / 細胞・組織 / 脳腫瘍 / CD44 / 細胞周期 / 遺伝子 / グリオーマ / メタロプロテアーゼ / チェックポイント / 細胞分裂 … More Except Principal Investigator NF2 / NF1 / p53 / Merlin / CD44 / プロテオミクス / Neurofibromin / 腫瘍抑制遺伝子 / 神経線維腫症 / Ku-antigen / Neurofibromatosis Type 2 / 神経線維腫症2型 / merlin / 癌 / メダカ / 口腔扁平上皮癌 / brain tumor / 細胞内シグナル伝達 / ノックアウトマウス / アポトーシス / 細胞・組織 / トランスジェニック / ノックアウト / トランスジェニックメダカ / glioma / トランスクリプトーム / 腫瘍抑制シグナル / siRNA / EMT / RB / 脳腫瘍 / poly(ADP-ribose)polymerase(PARP) / Tumor suppressor gene / Poly (ADP-ribose) polymerase (PARP) / malignant glioma / gene analysis / p16 / EGFR / prognosis / classification / Neurofibromatosis Type 1 / Proteomics / WARTS / グルタチオン / CD44v / がん遺伝子 / がん抑制遺伝子 / シグナル伝達 / がん細胞 / DNA修復 / がん転移 / ヒトゲノム / 2国間協同研究 / 2国間共同研究 / poly(ADP-ribose)polymerase / PARP / 細胞内会合タンパク質 / カイニン酸 / 虚血 / 脳 / 神経細胞 / NE-dlg / 遺伝子疾患モデルマウス / 遺伝学 / ウイルス / ゲノム / 遺伝子 / 細胞組織 / ウィルス / 性分化 / モデル動物 / 性分化異常 / 生殖腺 / マウス / トランスジェニックマウス / 外性器 / 性 / 乏突起神経膠腫 / 抗癌剤感受性 / 臨床マーカー / differential display / データマイニング / 虚血性アポトーシス / 2D-DICE / cICAT / 海馬 / 脳腫瘍学 / 神経系腫瘍 / 細胞分化 / 遺伝子導入 / 癌モデル生物 / 生体分子 / 癌幹細胞 / 幹細胞ニッチ / 分子標的治療 / 実験腫瘍学 / 腫瘍生物学 / 肝臓学 / pathway解析 / 大腸癌 / 浸潤・転移 / 消化器癌 / 細胞骨格 / 細胞運動 / 金属ステント / フリーラジカル / 超音波 / ステント / がん遺伝子導入メダカ / 抗癌剤スクリーニング / メダカ腫瘍モデル / HRAS / HRAS高発現 / RAS / 薬剤スクリーニング / 糖代謝 / pyruvate kinase M2 / 代謝変動 / 既存薬 / 解糖系 / グルコース代謝 / 好気性解糖 / ミトコンドリア呼吸 / 癌抑制遺伝子 / 発現ベクター / トランスフェクション / 分化誘導 / Tumor Suppressor Gene / Expression Vector / Trancefection / Differentiation / Apoptosis / 電気遺伝子療法 / 生体内電気穿孔法 / プラスミドDNA / lacZ遺伝子 / human MCP-1遺伝子 / ケモカイン / MCP-1遺伝子 / hMCP1 / electro-genetherapy (EGT) / in vivo electroporation / MCP-1 / lac Z gene / plasmid DNA / chemokine / 泌尿器癌 / 尿 / competitive RT-PCR / Competitive RT-PCR / 泌尿器科癌 / CD44遺伝子 / UROLOGIC CANCER / URINE / COMPETITIVE RT-PCR / invasin / マイクロスフィアー / 抗癌剤 / GST融合蛋白 / Invasin / microsphere / anti-cancer drug / GST-fusion protein / 肺癌 / 一酸化窒素合成酵素 / 特発性間質性肺炎 / 特発生間質性肺炎 / 繊維化 / NOS / Lung cancer / Nitric oxide synthase / Idiopathic interstitial pneumonia / nuclear export signal(NES) / NF2、 / 神経繊維腫症2型 / Cellular signal transduction / Nuclear export signal (NES) / LOH10 / glioblastoma / グリオーマ / 10番染色体 / LOH / PTEN / 生存日数 / 機能的解析 / LOH 10 / poly (ADP-ribose) polymerase (PARP) / DNA-PKs / 神経線維腫瘍2型 / poly (ADP-ribose)polymerase (PARP) / DNA-Pks / リン酸化 / プロテミクス / 学習障害 / ノックダウン / SiRNA / Omiプロテアーゼ / Lats1キナーゼ / mnd2マウス / 胸腺 / 脾臓 / Omi / HtrA2 protease / Latsl kinase / 小児外科学 / 小児腫瘍学 / 小児がん / 神経芽細胞腫 / 腫瘍幹細胞 / 循環腫瘍細胞 / 微小転移細胞 / 横紋筋肉腫 / 肝芽腫 / CD44v9 / 酸化ストレス / シスチントランスポーター / 胃癌幹細胞 / trastuzumab / シスチン / 胃がん / がん幹細胞 / 5-FU / PET / 生体内イメージング / ROS / 1p/19q codeletion / MGMT / neoadjuvant / chemotherapy / personalized treatment / RGNT / molecular classification / Glioma / neoadjuvant chemotherapy / image / 1p/19q / 神経膠腫 / 画像 / 1p19q / 特発性肺線維症 / 上皮間葉転換 / 肺胞上皮 / 肺線維症マウスモデル / ブレオマイシン / 遺伝子パネル検査 / 悪性リンパ腫 / 微小残存病変 / リキッドバイオプシー / 網羅的遺伝子変異解析 / 口腔がん / PDXマウスモデル / CD44ｖ / PDXモデル Less

Evaluation of minimal residual disease by liquid biopsy in malignant lymphoma for precise therapeutic stratification.
- Principal Investigator
  
  冨田章裕
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Fujita Health University
メチオニン代謝を基盤としたがん治療抵抗性機構の解明と新規治療標的の同定Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
がん関連線維芽細胞誘導分子機構の解明とその阻害に基づく腫瘍微小環境制御Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
PDXモデルを用いたCD44v陽性口腔がん幹細胞の特性評価と新規薬剤治療の確立
- Principal Investigator
  
  吉川桃子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
標準治療抵抗性口腔扁平上皮癌における標的可能遺伝子変異の同定と個別化治療の確立
- Principal Investigator
  
  莇生田整治
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57060:Surgical dentistry-related
- Research Institution
  Keio University
Development of new therapeutic agents for pancreatic cancer targeting 14-3-3dzetaPrincipal Investigator
- Principal Investigator
  
  Saya Hideyuki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Keio University
Elucidation of underlyingmechanism of MKL1-mediated induction of cancer associated fibroblasts and its clinical applicationsPrincipal Investigator
- Principal Investigator
  
  Saya Hideyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Analysis of escaping mechanism from immune system by microenvironment of cancer stem cellsPrincipal Investigator
- Principal Investigator
  
  Saya Hideyuki
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Towards personalized treatment of diffuse gliomas based on molecular characteristics
- Principal Investigator
  
  SASAKI HIKARU
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurosurgery
- Research Institution
  Keio University
EMT inhibitor for the treatment of idiopathic pulmonary fibrosis
- Principal Investigator
  
  Takahashi Fumiyuki
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Juntendo University
Development of a novel anti-invasion therapy targeting the glioma stem cell/endothelial cell invasion complexPrincipal Investigator
- Principal Investigator
  
  Saya Hideyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurosurgery
- Research Institution
  Keio University
The applied strategic research for the sake of cancer treatment; the discovery of puruvate kinase M2 (PKM2) activator out of existing drugs
- Principal Investigator
  
  TAMADA Mayumi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor biology
  Pathological medical chemistry
- Research Institution
  Keio University
Treatment sensitivity evaluation of oral squamous cell carcinoma based on the expression of a functional cancer stem cell marker CD44v
- Principal Investigator
  
  Asoda Seiji
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Keio University
Basic study for the development of PET diagnosis specific for CD44 variant-positive gastric cancer stem like cells
- Principal Investigator
  
  Suzuki Hidekazu
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Keio University
A novel prevention method for re-obstruction using titanium alloy stent with ultrasonic irradiation
- Principal Investigator
  
  ITANO Osamu
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical oncology
- Research Institution
  Keio University
Establishment of transgenic HRAS medaka as a tumor model for in vivo drug screening
- Principal Investigator
  
  MATSUZAKI Yuriko
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
Biological characterization of pediatric cancer stem cell, CTC, and DTC
- Principal Investigator
  
  Kuroda Tatsuo
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatric surgery
- Research Institution
  Keio University
The role of cell cycle regulator Cdh1 in carcinogenesis and development of gastrointestinal cancer.
- Principal Investigator
  
  NAOE Hideaki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Kumamoto University
Development of anti-metastatic strategy based on analysis of premetastatic nichePrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
Development of Novel Treatment Strategies Targeting Cancer Stem Cells
- Principal Investigator
  
  AKASHI Koichi
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Development of strategies to overcome therapeutic resistance by using induced cancer stem cells (iCSCs)Principal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Development of new strategies to overcome glioblastoma invasiveness and drug-resistance using a glioma stem cell modelPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Keio University
Study of the molecular mechanism of neural tumor formation mediatedby NF1 gene deficiency
- Principal Investigator
  
  ARAKI Norie
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
New classification of oral squamous cell carcinoma based on the molecular expression profile controlling the epithelial mesenchymal transition and stem cell-like characteristics
- Principal Investigator
  
  ASODA Seiji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Keio University
上皮間葉転換可視化システムを用いた癌浸潤転移阻害化合物スクリーニングPrincipal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor biology
- Research Institution
  Keio University
New melanoma model using transgenic medaka fish
- Principal Investigator
  
  MATSUZAKI Yuriko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Keio University
遺伝子改変メダカを用いた分裂異常に基づく発癌モデルの構築Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
Research for development of novel therapeutic approaches targeting molecules regulating invasion and drug resistance of malignant gliomasPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Keio University
Analysis of cellular signal transduction via Neurofibromatosis tumor suppressor gene products and development of their clinical targets
- Principal Investigator
  
  ARAKI Norie
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
細胞老化のリアルタイム解析法の確立とその応用による老化シグナルの解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
脳神経系特異的な虚血性細胞死の分子シグナル制御機構の解明
- Principal Investigator
  
  荒木令江
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Analysis of serine protease Omi-mediated-signaling pathway which could affect both tumorigenesis and neurodegenerative disorder
- Principal Investigator
  
  KUNINAKA Shinji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University
  Kumamoto University
Analysis of role of mitotic regulation and its abnormalities in carcinogenesisPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
  Kumamoto University
生体内3D器官再構築システムを用いた細胞周期制御分子異常による腫瘍形成機構の解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
プロテオミクス融合技術による乏突起神経膠腫の化学療法感受性メカニズムの解析
- Principal Investigator
  
  荒木令江
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Identification of molecules regulating resistance and invasiveness of malignant gliomas and development of new therapeutic approachesPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KEIO UNIVERSITY
  Kumamoto University
Genetic and Epigenetic Dysregulation in Cancer
- Principal Investigator
  
  NODA Tetsuo
- Project Period (FY)
  2004 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Japanese Foundation For Cancer Research
  Tohoku University
Reproduction and maintenance of experimental animals for the study of molecular mechanisms of sex differentiation
- Principal Investigator
  
  SASAOKA Toshikuni, NAGAHAMA Yoshitaka, 勝木元也
- Project Period (FY)
  2004 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute for Basic Biology
Aurora-Aキナーゼ過剰発現マウスによる悪性脳腫瘍発生モデルの作製Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Study for the cellular signal transduction of Neurofibromatosis Type 1 and Type 2 tumor suppressor gene products to establish the medical molecular target for NF1 and NF2
- Principal Investigator
  
  ARAKI Norie
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
RNA干渉法(RNAi)を用いた脳腫瘍浸潤抑制のための標的分子同定Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Analysis of molecular mechanisms of chemoresistance in malignant glioma cellsPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Study on cellular signal transduction of Neurofibromatosis Type 1 and Type 2 tumor suppressor gene products
- Principal Investigator
  
  ARAKI Norie
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
生体ストレスによる脳神経組織障害の発生メカニズムの解析--p53を介して誘導される脳神経系細胞死に関連するシグナル分子の検索--
- Principal Investigator
  
  荒木令江
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
細胞増殖の抑制とその破綻機構の解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kumamoto University
ヒト脳腫瘍細胞株を用いたin vitro遺伝子ターゲッティング-遺伝子変異と治療感受性の関連解析-Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Functional analysis of cell cycle regulators by in vitro gene targeting using DT40 cellsPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
Basic analysis for development of inhibitors of malignant glioma invasionPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University School of Medicine
Study on cellular signal transduction of Neurofibromatosis Type 2 tumor suppressor gene product (Merlin)
- Principal Investigator
  
  ARAKI Norie
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University School of Medicine
ヨーロッパなどががん研究先進国との研究交流
- Principal Investigator
  
  黒木登志夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Field
  
  Experimental pathology
- Research Institution
  Showa University
脳神経系腫瘍形成・進展に関与する分子の同定とその機能解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
細胞接着分子CD44の癌細胞における生物学的機能に関する日米協力研究Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kumamoto University
In vitro遺伝子ノックアウトによる細胞周期制御分子の機能解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kumamoto University
CLASSIFICATION OF MALIGNANT GLIOMAS BY MOLECULAR GENETIC ANALYSIS TO DEVELOP RATIONAL THERAPY
- Principal Investigator
  
  USHIO Yukitaka
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KUMAMOTO UNIVERSITY
細胞間接着蛋白E-カドヘリン分解制御による腫瘍細胞浸潤性の変化Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Experimental pathology
- Research Institution
  Kumamoto University
Identification of the novel genes which regulated differentiation of neuronal tissues and the diseases caused by their defectsPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Investigation of correlation between pulmonary fibrosis and carcinogenesis : Analysis about expression of p53, CD44 and nitric oxide synthase(NOS).
- Principal Investigator
  
  MATSUMOTO Mitsuhiro
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Respiratory organ internal medicine
- Research Institution
  Kumamoto University
Analysis of cellular function of Neurofibromatosis Type 2 tumor suppressor gene product (Merlin)
- Principal Investigator
  
  ARAKI Norie
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University School of Medicine
脳神経系腫瘍発生に関与する癌抑制遺伝子の機能とその異常の解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
ショウジョウバエ神経系腫瘍抑制遺伝子のヒト相同遺伝子の同定とその機能解析Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
神経線維腫症2型遺伝子産物(Merlin)の神経系腫瘍形成抑制機構の解析‥ Merlinに対する細胞内結合タンパク質の同定、及びその構造と相互作用機構の解析‥
- Principal Investigator
  
  荒木令江
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
Developement of a method for cancer treatment using invsin-conjugated microsphere
- Principal Investigator
  
  USHIO Yukitaka
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KUMAMOTO UNIVERSITY
酵母発現システムを用いたp53蛋白の転写機能調節因子の同定Principal Investigator
- Principal Investigator
  
  佐谷秀行
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University
Functional analysis of p53-induced apoptosis in glioma cellsPrincipal Investigator
- Principal Investigator
  
  SAYA Hideyuki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Kumamoto University
DEVELOPMENT OF GENE TRANSFER METHOD FOR SOLID TUMORS USING IN VIVO ELECTROPORATION.
- Principal Investigator
  
  USHIO Yukitaka
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  KUMAMOTO UNIVERSITY
THE ANALYSIS OF CD44 ALTERNATIVE SPLICING PATTERN IN UROLOGIC CANCER
- Principal Investigator
  
  MATUI Takashi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Urology
- Research Institution
  KOBE UNIVERSITY
Japan-US Collaborative studies on Tumor Suppressor Genes : Regulation of Cancer Cells by Modulating the Expression of Tumor Suppressor Genes.
- Principal Investigator
  
  TAKAHASHI Rei
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyoto University

[Journal Article] Oncogenic KRAS-expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice2021
- Author(s)
  Kasuga Akiyoshi、Semba Takashi、Sato Ryo、Nobusue Hiroyuki、Sugihara Eiji、Takaishi Hiromasa、Kanai Takanori、Saya Hideyuki、Arima Yoshimi
- Journal Title
  
  Cancer Science
  
  Volume: 印刷中 Pages: 1822-1838
- DOI
  10.1111/cas.14703
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07243
[Journal Article] Targeting of cancer stem cells by differentiation therapy2020
- Author(s)
  Arima Yoshimi、Nobusue Hiroyuki、Saya Hideyuki
- Journal Title
  
  Cancer Science
  
  Volume: 111 Pages: 2689-2695
- DOI
  10.1111/cas.14504
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07243
[Journal Article] Molecular and cellular mechanisms underlying brain metastasis of breast cancer2020
- Author(s)
  Hosonaga Mari、Saya Hideyuki、Arima Yoshimi
- Journal Title
  
  Cancer and Metastasis Reviews
  
  Volume: 39 Pages: 711-720
- DOI
  10.1007/s10555-020-09881-y
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518
[Journal Article] The Inhibitor of Apoptosis Protein Livin Confers Resistance to Fas-Mediated Immune Cytotoxicity in Refractory Lymphoma2020
- Author(s)
  Sugihara Eiji、Hashimoto Norisato、Osuka Satoru、Shimizu Takatsune、Ueno Sayaka、Okazaki Shogo、Yaguchi Tomonori、Kawakami Yutaka、Kosaki Kenjiro、Sato Taka-Aki、Okamoto Shinichiro、Saya Hideyuki
- Journal Title
  
  Cancer Research
  
  Volume: 80 Pages: 4439-4450
- DOI
  10.1158/0008-5472.can-19-3993
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16315, KAKENHI-PROJECT-19K24054, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K07247
[Journal Article] The insulin-PI3K-Rac1 Axis Contributes to Terminal Adipocyte Differentiation Through Regulation of Actin Cytoskeleton Dynamics.2020
- Author(s)
  Kunitomi H, Oki Y, Onishi N, Kano K, Banno K, Aoki D, Saya H, Nobusue H
- Journal Title
  
  Genes Cells
  
  Volume: 25 Pages: 165-174
- DOI
  10.1111/gtc.12747
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07243, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401
[Journal Article] Lung Adenocarcinoma Mouse Models Based on Orthotopic Transplantation of Syngeneic Tumor-Initiating Cells Expressing EpCAM, SCA-1, and Ly6d2020
- Author(s)
  Semba Takashi、Sato Ryo、Kasuga Akiyoshi、Suina Kentaro、Shibata Tatsuhiro、Kohno Takashi、Suzuki Makoto、Saya Hideyuki、Arima Yoshimi
- Journal Title
  
  Cancers
  
  Volume: 12 Pages: 3805-3805
- DOI
  10.3390/cancers12123805
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08968, KAKENHI-PROJECT-20H00518
[Journal Article] 2-Nitroimidazoles induce mitochondrial stress and ferroptosis in glioma stem cells residing in a hypoxic niche.2020
- Author(s)
  Koike Naoyoshi、Kota Ryuichi、Naito Yoshiko、Hayakawa Noriyo、Matsuura Tomomi、Hishiki Takako、Onishi Nobuyuki、Fukada Junichi、Suematsu Makoto、Shigematsu Naoyuki、Saya Hideyuki、Sampetrean Oltea
- Journal Title
  
  Commun Biol.
  
  Volume: 3 Pages: 450-462
- DOI
  10.1038/s42003-020-01165-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07671, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-20K16801, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18K07771
[Journal Article] Blood and lymphatic systems are segregated by the FLCN tumor suppressor2020
- Author(s)
  Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Hirashima M, Suzuki Y, Furuya M, Baba M, Kubota Y
- Journal Title
  
  Nature Communications volume
  
  Volume: 11 Pages: 1-12
- DOI
  10.1038/s41467-020-20156-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07430, KAKENHI-PUBLICLY-19H04791, KAKENHI-PROJECT-20H00518, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-19H03397, KAKENHI-PROJECT-20H03724, KAKENHI-PROJECT-20K07395, KAKENHI-PROJECT-19K16696, KAKENHI-PROJECT-18KK0230, KAKENHI-PROJECT-16H06276
[Journal Article] Rock inhibition suppresses osteosarcoma tumorigenesis by inducing terminal adipocyte differentiation in chemoresistant stemlike cells2019
- Author(s)
  Takahashi N, Nobusue H, Shimizu T, Sugihara E, Yamaguchi-Iwai S, Onishi N, Kunitomi H, Kuroda T, Saya H
- Journal Title
  
  Cancer Research
  
  Volume: online first Issue: 12 Pages: 3088-3099
- DOI
  10.1158/0008-5472.can-18-2693
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-18K07224, KAKENHI-PROJECT-18K07247, KAKENHI-PROJECT-19K07696, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H04355, KAKENHI-PROJECT-16H06276
[Journal Article] Modeling Sporadic Als in Ipsc-Derived Motor Neurons Identifies a Potential Therapeutic Agent2018
- Author(s)
  Fujimori K, Ishikawa M, Otomo A, Atsuta N, Nakamura R, Akiyama T, Hadano S, Aoki M, Saya H, Sobue G, Okano H.
- Journal Title
  
  Nature Medicine
  
  Volume: 24 Pages: 1579-1589
- DOI
  10.1038/s41591-018-0140-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K09778, KAKENHI-ORGANIZER-26117001, KAKENHI-PLANNED-26117002, KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17K16116
[Journal Article] T-type Calcium Channels Determine the Vulnerability of Dopaminergic Neurons to Mitochondrial Stress in Familial Parkinson Disease2018
- Author(s)
  Tabata Yoshikuni、Imaizumi Yoichi、Sugawara Michiko、Andoh-Noda Tomoko、Banno Satoe、Chai MuhChyi、Sone Takefumi、Yamazaki Kazuto、Ito Masashi、Tsukahara Kappei、Saya Hideyuki、Hattori Nobutaka、Kohyama Jun、Okano Hideyuki
- Journal Title
  
  Stem Cell Reports
  
  Volume: 11 Pages: 1171-1184
- DOI
  10.1016/j.stemcr.2018.09.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-26117007, KAKENHI-PROJECT-17H01401
[Journal Article] Synthetic lethality of the ALDH3A1 inhibitor dyclonine and xCT inhibitors in glutathione deficiency-resistant cancer cells.2018
- Author(s)
  Okazaki Shogo、Shintani Subaru、Hirata Yuki、Suina Kentaro、Semba Takashi、Yamasaki Juntaro、Umene Kiyoko、Ishikawa Miyuki、Saya Hideyuki、Nagano Osamu
- Journal Title
  
  Oncotarget
  
  Volume: 9 Pages: 33832-33843
- DOI
  10.18632/oncotarget.26112
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-18J14396
[Journal Article] Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model.2018
- Author(s)
  Shibao S、Minami N、Koike N、Fukui N、Yoshida K、Saya H、Sampetrean O
- Journal Title
  
  Neuro-Oncology
  
  Volume: 20 Pages: 343-354
- DOI
  10.1093/neuonc/nox170
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17J02715
[Journal Article] Inhibiting xCT improves 5-fluorouracil resistance of gastric cancer induced by CD44 variant 9 expression.2018
- Author(s)
  Miyoshi S, Tsugawa H, Matsuzaki J, Hirata K, Mori H, Saya H, Kanai T, Suzuki H.
- Journal Title
  
  Anticancer Res.
  
  Volume: 38 Pages: 6163-6170
- DOI
  10.21873/anticanres.12969
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16H05291, KAKENHI-PROJECT-16K08349
[Journal Article] Epidermal growth factor receptor promotes glioma progression by regulating xCT and GluN2B-containing N-methyl-d-aspartate-sensitive glutamate receptor signaling2018
- Author(s)
  Suina K, Tsuchihashi K, Yamasaki J, Kamenori S, Shintani S, Hirata Y, Okazaki S, Sampetrean O, Baba E, Akashi K, Takahashi F, Takahashi K, Saya H, Nagano O.
- Journal Title
  
  Cancer Science
  
  Volume: 109 Pages: 3874-3882
- DOI
  10.1111/cas.13826
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09669, KAKENHI-PROJECT-18K08185, KAKENHI-PROJECT-18K15215, KAKENHI-PROJECT-18K15223, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03583, KAKENHI-PROJECT-15K09230, KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-18J14396
[Journal Article] Stat3 as a potential therapeutic target for rheumatoid arthritis.2017
- Author(s)
  Oike T, Sato Y, Kobayashi T, Miyamoto K, Nakamura S, Kaneko Y, Kobayashi S, Harato K, Saya H, Matsumoto M, Nakamura M, Niki Y, Miyamoto T.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 10965-10965
- DOI
  10.1038/s41598-017-11233-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10917, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04963, KAKENHI-PROJECT-15K10490
[Journal Article] Reducing inflammatory cytokine production from renal collecting duct cells by inhibiting GATA2 ameliorates acute kidney injury2017
- Author(s)
  Yu L, Moriguchi T, Kaneko H, Hayashi M, Hasegawa A, Nezu M, Saya H, Yamamoto M, Shimizu R.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 37 Pages: 00211-217
- DOI
  10.1128/mcb.00211-17
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04759, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-17J04895
[Journal Article] Inflammatory mediator ultra-low-molecular-weight hyaluronan triggers necrosis of B-precursor leukemia cells with high surface CD44 expression.2017
- Author(s)
  Kasai S, Furuichi Y, Ando N, Kagami K, Abe M, Nakane T, Goi K, Inukai T, Saitoh S, Ohno S, Okazaki S, Nagano O, Saya H, Sugita K.
- Journal Title
  
  Cell Death Dis.
  
  Volume: 8
- DOI
  10.1038/cddis.2017.249
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15K09645
[Journal Article] The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer2017
- Author(s)
  Tayama S, Motohara T, Narantuya D, Li C, Fujimoto K, Sakaguchi I, Tashiro H, Saya H, Nagano O, Katabuchi H
- Journal Title
  
  Oncotarget
  
  Volume: 8 Pages: 44312-44325
- DOI
  10.18632/oncotarget.17871
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K11145, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16H05473
[Journal Article] cRGD peptide installation on cisplatin-loaded nanomedicines enhances efficacy against locally advanced head and neck squamous cell carcinoma bearing cancer stem-like cells.2017
- Author(s)
  Miyano Kazuki、Cabral Horacio、Miura Yutaka、Matsumoto Yu、Mochida Yuki、Kinoh Hiroaki、Iwata Caname、Nagano Osamu、Saya Hideyuki、Nishiyama Nobuhiro、Kataoka Kazunori、Yamasoba Tatsuya
- Journal Title
  
  J. Control. Release
  
  Volume: 261 Pages: 275-286
- DOI
  10.1016/j.jconrel.2017.06.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-16K11226, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15H04635, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-16H05422, KAKENHI-PROJECT-17H06641, KAKENHI-PROJECT-16F16058, KAKENHI-PROJECT-16F16407, KAKENHI-PROJECT-16K15104
[Journal Article] Phase I study of salazosulfapyridine in combination with cisplatin and pemetrexed for advanced non-small-cell lung cancer.2017
- Author(s)
  Otsubo K, Nosaki K, Imamura CK, Ogata H, Fujita A, Sakata S, Hirai F, Toyokawa G, Iwama E, Harada T, Seto T, Takenoyama M, Ozeki T, Mushiroda T, Inada M, Kishimoto J, Tsuchihashi K, Suina K, Nagano O, Saya H, Nakanishi Y, Okamoto I.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1843-1849
- DOI
  10.1111/cas.13309
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401
[Journal Article] Calcitriol exerts an anti-tumor effect in osteosarcoma by inducing the endoplasmic reticulum stress response.2017
- Author(s)
  Shimizu T, Kamel WA, Yamaguchi-Iwai S, Fukuchi Y, Muto A, Saya H.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1793-1802
- DOI
  10.1111/cas.13304
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-16J40108, KAKENHI-PROJECT-15K06845
[Journal Article] Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells2017
- Author(s)
  Ishimoto T, Miyake K, Nandi T, Yashiro M, Onishi N, Huang KK, Joyce LN, Kalpana R, Tay ST, Suzuki Y, Cho BC, Kuroda D, Arima K, Izumi D, Iwatsuki M, Baba Y, Oki E, Watanabe M, Saya H, Hirakawa K, Baba H, Tan P.
- Journal Title
  
  Gastroenterology.
  
  Volume: in press Pages: 191-204
- DOI
  10.1053/j.gastro.2017.03.046
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06257, KAKENHI-PROJECT-26293290, KAKENHI-PROJECT-16K15595, KAKENHI-PROJECT-16K07125, KAKENHI-PROJECT-17K10596, KAKENHI-PROJECT-17K10639, KAKENHI-PROJECT-26293307, KAKENHI-PROJECT-17H01401
[Journal Article] Phase 1 study of sulfasalazine and cisplatin for patients with CD44v-positive gastric cancer refractory to cisplatin (EPOC1407)2017
- Author(s)
  Shitara K, Doi T, Nagano O, Fukutani M, Hasegawa H, Nomura S, Sato A, Kuwata T, Asai K, Einaga Y, Tsuchihashi K, Suina K, Maeda Y, Saya H, Ohtsu A.
- Journal Title
  
  Gastric Cancer
  
  Volume: 20 Pages: 1004-1009
- DOI
  10.1007/s10120-017-0720-y
- NAID
  40021377421
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17J02923
[Journal Article] FZR1 loss increases sensitivity to DNA damage and consequently promotes murine and human B-cell acute leukemia.2017
- Author(s)
  Ishizawa J, Sugihara E, Kuninaka S, Mogushi K, Kojima K, Benton CB, Zhao R, Chachad D, Hashimoto N, Jacamo RO, Qiu Y, Yoo SY, Okamoto S, Andreeff M, Kornblau SM, Saya H.
- Journal Title
  
  Blood
  
  Volume: 129 Pages: 1958-1968
- DOI
  10.1182/blood-2016-07-726216
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461425, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-15K06840
[Journal Article] Organotypic brain explant culture as a drug evaluation system for malignant brain tumors.2017
- Author(s)
  Minami N、Maeda Y、Shibao S、Arima Y、Ohka F、Kondo Y、Maruyama K、Kusuhara M、Sasayama T、Kohmura E、Saya H、Sampetrean O
- Journal Title
  
  Cancer Med
  
  Volume: 6 Pages: 2635-2645
- DOI
  10.1002/cam4.1174
- NAID
  120006373813
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07124, KAKENHI-PROJECT-17K10863, KAKENHI-PROJECT-17H01401, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-17J02715, KAKENHI-PROJECT-15K10332
[Journal Article] MIF maintains the tumorigenic capacity of brain tumor-initiating cells by directly inhibiting p532016
- Author(s)
  Fukaya R, Ohta S, Yaguchi T, Matsuzaki Y, Sugihara E, Okano H, Saya H, Kawakami Y, Kawase T, Yoshida K and Toda M
- Journal Title
  
  Cancer Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253085
[Journal Article] ALKR1275Q perturbs extracellular matrix, enhances cell invasion, and leads to the development of neuroblastoma in cooperation with MYCN.2016
- Author(s)
  Ueda T, Nakata Y, Yamasaki N, Oda H, Sentani K, Kanai A, Onishi N, Ikeda K, Sera Y, Honda ZI, Tanaka K, Sata M, Ogawa S, Yasui W, Saya H, Takita J, Honda H.
- Journal Title
  
  Oncogene
  
  Volume: 無 Pages: 4447-4458
- DOI
  10.1038/onc.2015.519
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K16125, KAKENHI-PROJECT-15J06501, KAKENHI-PROJECT-25460416, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-26670493, KAKENHI-PROJECT-25293184, KAKENHI-PROJECT-26293242, KAKENHI-PROJECT-26293227, KAKENHI-PROJECT-16K08691
[Journal Article] The EGF receptor promotes the malignant potential of glioma by regulating amino acid transport system xc(-)2016
- Author(s)
  Tsuchihashi K, Okazaki S, Ohmura M, Ishikawa M, Sampetrean O, Onishi N, Wakimoto H, Yoshikawa M, Seishima R, Iwasaki Y, Morikawa T, Abe S, Takao A, Shimizu M, Masuko T, Nagane M, Furnari FB, Akiyama T, Suematsu M, Baba E, Akashi K, Saya H and Nagano O
- Journal Title
  
  Cancer Res
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25253085
[Journal Article] Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry2015
- Author(s)
  Ohmura M, Hishiki T, Yamamoto T, Nakanishi T, Kubo A, Tsuchihashi K, Tamada M, Toue S, Kabe Y, Saya H and Suematsu M
- Journal Title
  
  Nitric Oxide
  
  Volume: pii: S1089-8603 Pages: 102-113
- DOI
  10.1016/j.niox.2014.11.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24510304, KAKENHI-PROJECT-25870717, KAKENHI-PUBLICLY-26117726, KAKENHI-PROJECT-15K07011, KAKENHI-PROJECT-25513008
[Journal Article] Dynamic epigenetic regulation of glioblastoma tumorigenicity through LSD1 modulation of MYC expression2015
- Author(s)
  Kozono D, Li J, Nitta M, Sampetrean O, Gonda D, Kushwaha DS, Merzon D, Ramakrishnan V, Zhu S, Zhu K, Matsui H, Harismendy O, Hua W, Mao Y, Kwon CH, Saya H, Nakano I, Pizzo DP, VandenBerg SR and Chen CC
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 112 Pages: 112-130
- DOI
  10.1073/pnas.1501967112
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-26861168
[Journal Article] Expression of TNF-α and CD44 is implicated in poor prognosis, cancer cell invasion, metastasis and resistance to the sunitinib treatment in clear cell renal cell carcinomas.2015
- Author(s)
  Mikami S, Mizuno R, Kosaka T, Saya H, Oya M and Okada Y
- Journal Title
  
  Int J Cancer
  
  Volume: 136 Pages: 1504-1514
- DOI
  10.1002/ijc.29137
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390374, KAKENHI-PROJECT-25460422
[Journal Article] Periostin Is a Key Niche Component for Wound Metastasis of Melanoma2015
- Author(s)
  Fukuda K, Sugihara E, Ohta S, Izuhara K, Funakoshi T, Amagai M, Saya H.
- Journal Title
  
  PLOS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0129704
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PROJECT-15K09553, KAKENHI-PROJECT-15K15372, KAKENHI-PROJECT-15K19704, KAKENHI-PROJECT-15K14384, KAKENHI-PROJECT-25293224
[Journal Article] Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma2015
- Author(s)
  Adachi T, Kobayashi T, Sugihara E, Yamada T, Ikuta K, Pittaluga S, Saya H, Amagai M, Nagao K.
- Journal Title
  
  Nat Med
  
  Volume: 21 Pages: 1272-1272
- DOI
  10.1038/nm.3962
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06840, KAKENHI-PUBLICLY-15H01153, KAKENHI-PROJECT-26253065, KAKENHI-PROJECT-25460589, KAKENHI-PROJECT-15K14384
[Journal Article] TNF-a/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells2014
- Author(s)
  Oshima H, Ishikawa T, Yoshida GJ, Naoi K, Maeda Y, Naka K, Ju X, Yamada Y, Minamoto T, Mukaida N, Saya H, Oshima M.
- Journal Title
  
  Oncogene
  
  Volume: 33 Pages: 1-10
- DOI
  10.1038/onc.2013.356
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22114005, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24300325, KAKENHI-PROJECT-24501314, KAKENHI-PROJECT-25430107, KAKENHI-PROJECT-25670572
[Journal Article] Regulation of MKL1 via actin cytoskeleton dynamics drives adipocyte differentiation2014
- Author(s)
  Nobusue H
- Journal Title
  
  Nature Communications
  
  Volume: 5 Pages: 3368-3368
- DOI
  10.1038/ncomms4368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25253069, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245
[Journal Article] Inversed relationship between CD44 variant and c-Myc due to oxidative stress-induced canonical Wnt activation.2014
- Author(s)
  Yoshida GJ and Saya H
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 443 Pages: 622-627
- DOI
  10.1016/j.bbrc.2013.12.016
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] TSPAN2 Is Involved in Cell Invasion and Motility during Lung Cancer Progression.2014
- Author(s)
  Otsubo C, Otomo R, Miyazaki M, Matsushima-Hibiya Y, Kohno T, Iwakawa R, Takeshita F, Okayama H, Ichikawa H, Saya H, Kiyono T, Ochiya T, Tashiro F, Nakagama H, Yokota J and Enari M
- Journal Title
  
  Cell Rep
  
  Volume: 7 Pages: 527-538
- DOI
  10.1016/j.celrep.2014.03.027
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model.2014
- Author(s)
  Saga I, Shibao S, Okubo J, Osuka S, Kobayashi Y, Yamada S, Fujita S, Urakami K, Kusuhara M, Yoshida K, Saya H, Sampetrean O
- Journal Title
  
  Neuro Oncol
  
  Volume: 16 Pages: 1048-1056
- DOI
  10.1093/neuonc/nou096
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-13J06657, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-26830082, KAKENHI-PROJECT-26861168
[Journal Article] Expression of CD24 is associated with HER2 expression and supports HER2-Akt signaling in HER2-positive breast cancer cells.2014
- Author(s)
  Hosonaga M, Arima Y, Sugihara E, Kohno N and Saya H
- Journal Title
  
  Cancer Sci.
  
  Volume: 105 Pages: 779-787
- DOI
  10.1111/cas.12427
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-25461995, KAKENHI-PROJECT-25860245
[Journal Article] TNFα promotes osteosarcoma progression by maintaining tumor cells in an undifferentiated state2014
- Author(s)
  Mori T
- Journal Title
  
  Oncogene
  
  Volume: Epub ahead of print Pages: 4236-4241
- DOI
  10.1038/onc.2013.545
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390359, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-24592244, KAKENHI-PROJECT-25861341
[Journal Article] A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.2014
- Author(s)
  Inagawa Y, Yamada K, Yugawa T, Ohno SI, Hiraoka N, Esaki M, Shibata T, Aoki K, Saya H and Kiyono T
- Journal Title
  
  Carcinogenesis
  
  Volume: 35 Pages: 1840-1846
- DOI
  10.1093/carcin/bgu112
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-26460406
[Journal Article] がん幹細胞マーカーCD44による細胞内グルタチオン制御2014
- Author(s)
  玉田真由美　佐谷秀行
- Journal Title
  
  細胞
  
  Volume: Vol.46 No.3
- Data Source
  KAKENHI-PROJECT-25870717
[Journal Article] Functional analysis of a novel glioma antigen, EFTUD1.2014
- Author(s)
  Saito K, Iizuka Y, Ohta S, Takahashi S, Nakamura K, Saya H, Yoshida K, Kawakami Y and Toda M
- Journal Title
  
  Neuro-Oncol
  
  Volume: 16 Pages: 1618-1629
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] IGF2 preserves osteosarcoma cell survival by creating an autophagic state of dormancy that protects cells against chemotherapeutic stress.2014
- Author(s)
  Shimizu T, Sugihara E, Yamaguchi-Iwai S, Tamaki S, Koyama Y, Kamel W, Ueki A, Ishikawa T, Chiyoda T, Osuka S, Onishi N, Ikeda H, Kamei J, Matsuo K, Fukuchi Y, Nagai T, Toguchida J, Toyama Y, Muto A, Saya H
- Journal Title
  
  Cancer Research
  
  Volume: 74 Pages: 6531-41
- DOI
  10.1158/0008-5472.can-14-0914
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J06657, KAKENHI-ORGANIZER-22130001, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390353, KAKENHI-PROJECT-24501320, KAKENHI-PROJECT-25830088, KAKENHI-PROJECT-25860245, KAKENHI-PROJECT-26830082
[Journal Article] A stem cell medium containing neural stimulating factor induces a pancreatic cancer stem-like cell-enriched population2014
- Author(s)
  Watanabe Y, Yoshimura K, Yoshikawa K, Tsunedomi R, Shindo Y, Matsukuma S, Maeda N, Kanekiyo S, Suzuki N, Kuramasu A, Sonoda K, Tamada K, Kobayashi S, Saya H, Hazama S and Oka M
- Journal Title
  
  International Journal of Oncology
  
  Volume: 45 Pages: 1857-1866
- DOI
  10.3892/ijo.2014.2603
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24390317, KAKENHI-PROJECT-25290057, KAKENHI-PROJECT-25861192, KAKENHI-PROJECT-26293373, KAKENHI-PROJECT-26670755
[Journal Article] CD44s signals the acquisition of the mesenchymal phenotype required for anchorage-independent cell survival in hepatocellular carcinoma2014
- Author(s)
  Okabe H, Ishimoto T, Mima K, Nakagawa S, Hayashi H, Kuroki H, Imai K, Nitta H, Saito S, Hashimoto D, Chikamoto A, Ishiko T, Watanabe M, Nagano O, Beppu T, Saya H and Baba H
- Journal Title
  
  British Journal of Cancer
  
  Volume: 印刷中 Pages: 958-66
- DOI
  10.1038/bjc.2013.759
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-23791549, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24592008
[Journal Article] Functional analysis of a novel glioma antigen, EFTUD12014
- Author(s)
  Saito K, Iizuka Y, Ohta S, Takahashi S, Nakamura K, Saya H, Yoshida K, Kawakami Y, Toda M
- Journal Title
  
  Neuro-Oncology
  
  Volume: 16 Pages: 1618-1629
- DOI
  10.1093/neuonc/nou132
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24592172, KAKENHI-PROJECT-24659657, KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-25293313
[Journal Article] Characteristics of glioma stem cells2013
- Author(s)
  Sampetrean O and Saya H
- Journal Title
  
  Brain Tumor Pathol2013
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] CD44 variant 9 expression in primary early gastric cancer as a predictive marker for recurrence2013
- Author(s)
  Hirata K, Suzuki H, Imaeda H, Matsuzaki J, Tsugawa H, Nagano O, Asakura K, Saya H, Hibi T
- Journal Title
  
  Br. J. Cancer.
  
  Volume: 109 Pages: 379-386
- DOI
  10.1038/bjc.2013.314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-25460173
[Journal Article] xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma2013
- Author(s)
  Yoshikawa M, Tsuchihashi K, Ishimoto T, Yae T, Motohara T, Sugihara E, Onishi N, Masuko T, Yoshizawa K, Kawashiri S, Mukai M, Asoda S, Kawana H, Nakagawa T, Saya H, Nagano O
- Journal Title
  
  Cancer Resaerch
  
  Volume: 73(6) Pages: 1855-1866
- DOI
  10.1158/0008-5472.can-12-3609-t
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22592100, KAKENHI-PROJECT-23659941, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-24591912, KAKENHI-PROJECT-24592965, KAKENHI-PROJECT-24791713, KAKENHI-PROJECT-24792194, KAKENHI-PROJECT-25293344, KAKENHI-PROJECT-25870730, KAKENHI-PLANNED-22130007
[Journal Article] Establishment of HRASG12V transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs.2013
- Author(s)
  Matsuzaki Y, Hosokai H, Mizuguchi Y, Fukamachi S, Shimizu A, Saya H
- Journal Title
  
  PLoS One
  
  Volume: 8
- DOI
  10.1371/journal.pone.0054424
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24591633, KAKENHI-PLANNED-22130007
[Journal Article] Functional role of CD44v-xCT system in the development of spasmolytic polypeptide-expressing metaplasia.2013
- Author(s)
  Wada T, Ishimoto T, Seishima R, Tsuchihashi K, Yoshikawa M, et al
- Journal Title
  
  Cancer Sci
  
  Volume: 104 Pages: 1323-1329
- DOI
  10.1111/cas.12236
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06428, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24590389, KAKENHI-PROJECT-24591912
[Journal Article] Acquired expression of NFATc1 downregulates E-cadherin and promotes cancer cell invasion2013
- Author(s)
  Oikawa T
- Journal Title
  
  Cancer Res.
  
  Volume: 73 Pages: 5100-5109
- DOI
  10.1158/0008-5472.can-13-0274
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-23659162, KAKENHI-PROJECT-23689020, KAKENHI-PROJECT-25253085, KAKENHI-PROJECT-25830088
[Journal Article] The APC/C activator Cdh1 regulates the G2/M transition during differentiation of placental trophoblast stem cells2013
- Author(s)
  Naoe H, Chiyoda T, Ishizawa J, Masuda K, Saya H, Kuninaka S
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 430(2) Pages: 757-62
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] In vivo pH monitoring using boron doped diamond microelectrode and silver needles: application to stomach disorder diagnosis.2013
- Author(s)
  Fierro S, Seishima R, Nagano O, Saya H and Einaga Y
- Journal Title
  
  Sci Rep.
  
  Volume: 3 Pages: 3257-3257
- DOI
  10.1038/srep03257
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-24590389
[Journal Article] IGF1 receptor signaling regulates adaptive radioprotection in glioma stem cells.2013
- Author(s)
  Osuka S, Sampetrean O, Saya H et al.
- Journal Title
  
  Stem Cells
  
  Volume: 31 Pages: 627-640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Induction of ZEB by inactivation of RB is a key determinant of the mesenchymal phenotype of breast cancer2012
- Author(s)
  Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, Kuninaka S, Shibata T, Ohata H, Nakagama H, Taya Y and Saya H
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 7896-7906
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591444
[Journal Article] LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression2012
- Author(s)
  Chiyoda T, Sugiyama N, Shimizu T, Naoe H, Kobayashi Y, Ishizawa J, Arima Y, Tsuda H, Ito M, Kaibuchi K, Aoki D, Ishihama Y, Saya H, and Kuninaka S.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] Ink4a and Arf are crucial factors in the determination of the cell of origin and the therapeutic sensitivity of Myc-induced mouse lymphoid tumor.2012
- Author(s)
  Sugihara E, Saya H, et al
- Journal Title
  
  Oncogene
  
  Volume: (印刷中) Pages: 2849-2861
- DOI
  10.1038/onc.2011.462
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-23590350, KAKENHI-PROJECT-23616003, KAKENHI-PROJECT-23790376
[Journal Article] odulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012
- Author(s)
  Mayumi Tamada, et al
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 1438-1448
- DOI
  10.1158/0008-5472.can-11-3024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J55543, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-22710222, KAKENHI-PROJECT-23790376
[Journal Article] RNA-Binding Protein Musashi1 Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI(3) Kinase/Akt Signaling Pathways2012
- Author(s)
  Muto J, Saya H et al.
- Journal Title
  
  PLos One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Fibroblast growth factor-2 (Fgf2) is an important factor that maintains cellular immaturity and contributes to aggressiveness of osteosarcoma2012
- Author(s)
  Shimizu T., et al
- Journal Title
  
  Mol. Cancer Res.
  
  Volume: 10(3) Pages: 454-468
- DOI
  10.1158/1541-7786.mcr-11-0347
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J06969, KAKENHI-PLANNED-22130007, KAKENHI-PROJECT-22241052, KAKENHI-PROJECT-22700865, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-23791293, KAKENHI-PROJECT-24590360
[Journal Article] Loss of p16 expression is associated with the stem cell characteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer2012
- Author(s)
  Arima Y, Hayashi N, Hayashi H, Sasaki M, Kai K, Sugihara E, Abe E, Yoshida A, Mikami S, Nakamura S and Saya H
- Journal Title
  
  Int J Cancer
  
  Volume: 130 Pages: 2568-2579
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591444
[Journal Article] Induction of ZEB by inactivation of RB is a key determinant of the mesenchymal phenotype of breast cancer.2012
- Author(s)
  Arima Y, Saya H, et al
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 7896-7906
- DOI
  10.1074/jbc.m111.313759
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650601, KAKENHI-PROJECT-24590360
[Journal Article] Loss of p16 expression is associated with the stem cellcharacteristics of surface markers and therapeutic resistance in estrogen receptor-negative breast cancer.2012
- Author(s)
  Arima Y, Saya H, et al
- Journal Title
  
  Int J Cancer.
  
  Volume: 130 Pages: 2568-2579
- DOI
  10.1002/ijc.26271
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23650601, KAKENHI-PROJECT-23790376, KAKENHI-PROJECT-23791496
[Journal Article] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2012
- Author(s)
  Tamada M, Nagano O, Tateyama S, Ohmura M, Yae T, Ishimoto T, Sugihara E, Onishi N, Yamamoto T, Yanagawa H, Suematsu M and Saya H
- Journal Title
  
  Cancer Res
  
  Volume: 72 Pages: 1438-1448
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591444
[Journal Article] RNA-Binding Protein Musashil Modulates Glioma Cell Growth through the Post-Transcriptional Regulation of Notch and PI(3) Kinase/Akt Signaling Pathways2012
- Author(s)
  Muto J, Saya H, et al
- Journal Title
  
  PLos One
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Induction of ZEB Proteins by Inactivation of RB Protein Is Key Determinant of Mesenchymal Phenotype of Breast Cancer2012
- Author(s)
  Yoshimi Arima, Hidemi Hayashi, Mikako Sasaki, Mari Hosonaga, Takaaki M. Goto, Tatsuyuki Chiyoda, Shinji Kuninaka, Tatsuhiro Shibata, Hirokazu Ohata, Hitoshi Nakagama, Yoichi Taya, Hideyuki Saya
- Journal Title
  
  J Biol Chem
  
  Volume: 287 Pages: 7896-7906
- Data Source
  KAKENHI-PROJECT-23650601
[Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress.2011
- Author(s)
  Ishizawa J, Saya H, et al.
- Journal Title
  
  Cancer Sci
- NAID
  10029293305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] NKX2.2 suppresses self renewal of glioma-initiating cells.2011
- Author(s)
  Muraguchi T, Saya H, et al.
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 1135-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells.2011
- Author(s)
  Sampetrean O, Saya H et al
- Journal Title
  
  Neoplasia
  
  Volume: 13 Pages: 784-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] NKX2.2 suppresses self renewal of glioma-initiating cells.2011
- Author(s)
  Muraguchi T, Saya H, et al.
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 1135-1145
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] Loss of p16 expression is associated with the stem cell characteristics of sureface markers and therapeutic resistance in estrogen receptor-negative breast cancer2011
- Author(s)
  Arima Y, Naoki Hayashi, Hidemi Hayashi, Mikako Sasaki, Kazuharu Kai, Eiji Sugihara, Eriko Abe, Atsushi Yoshida, Shuji Mikami, Seigo Nakamura, Hideyuki Saya
- Journal Title
  
  Int J Cancer
  
  Volume: 130 Pages: 2568-2579
- Data Source
  KAKENHI-PROJECT-23650601
[Journal Article] Establishment of a Choriocarcinoma Model from Immortalized Normal Extravillous Trophoblast Cells Transduced with HRASV122011
- Author(s)
  Kobayashi Y, Shimizu T, Naoe H, Ueki A, Ishizawa J, Chiyoda T, Onishi N, Sugihara E, Nagano O, Banno K, Kuninaka S, Aoki D, Saya H.
- Journal Title
  
  The American Journal of Pathology
  
  Volume: 179 Pages: 1471-1482
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells2011
- Author(s)
  Sampetrean O, Saya H, et al
- Journal Title
  
  Neoplasia
  
  Volume: 13 Pages: 784-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress.2011
- Author(s)
  Ishizawa J, Saya H, et al.
- Journal Title
  
  Cancer Sci
- NAID
  10029293305
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc- and thereby promotes tumor growth.2011
- Author(s)
  Ishimoto T, Saya H, et al.
- Journal Title
  
  Cancer Cell
  
  Volume: 19 Pages: 387-400
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc(-) and Thereby Promotes Tumor Growth2011
- Author(s)
  Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, Oshima M, Ikeda T, Asaba R, Yagi H, Masuko T, Shimizu T, Ishikawa T, Kai K, Takahashi E, Imamura Y, Baba Y, Ohmura M, Suematsu M, Baba H, Saya H
- Journal Title
  
  Cancer Cell
  
  Volume: 19(3) Pages: 387-400
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc- and thereby promotes tumor growth.2011
- Author(s)
  Ishimoto T, Saya H et al
- Journal Title
  
  Cancer Cell
  
  Volume: 19 Pages: 387-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress2011
- Author(s)
  Ishizawa J, Saya H et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 967-974
- NAID
  10029293305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress2011
- Author(s)
  Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H.
- Journal Title
  
  Cancer Science
  
  Volume: 22 Pages: 1-8
- NAID
  10029293305
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590980
[Journal Article] Functional analysis of HOXD9 in human gliomas and glioma cancer stem cells2011
- Author(s)
  Tabuse M, Ohta S, Ohashi Y, Fukaya R, Misawa A, Yoshida K, Kawase T, Saya H, Thirant C, Chneiweiss H, Matsuzaki Y, Okano H, Kawakami Y, Toda M
- Journal Title
  
  Molecular Cancer
  
  Volume: 10 Pages: 60-60
- DOI
  10.1186/1476-4598-10-60
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390062, KAKENHI-PROJECT-22249055, KAKENHI-PROJECT-22390283, KAKENHI-PROJECT-22791356, KAKENHI-PROJECT-23240128
[Journal Article] Invasion precedes tumor mass formation in a malignant brain tumor model of genetically modified neural stem cells2011
- Author(s)
  Sampetrean O, Saga I, Nakanishi M, Sugihara E, Fukaya R, Onishi N, Osuka A, Akahata M, Kai K, Sugimoto H, Hirao A, and Saya H
- Journal Title
  
  Neoplasia
  
  Volume: 13 Pages: 784-791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591444
[Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells2011
- Author(s)
  Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A
- Journal Title
  
  Cancer Res
  
  Volume: 71(3) Pages: 1135-45
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation2010
- Author(s)
  Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
- Journal Title
  
  Mol Cell Biol
  
  Volume: 30(16) Pages: 3994-4005
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] PRKAR1A is over-expressed and represents a possible therapeutic target in human cholangiocarcinoma.2010
- Author(s)
  Loilome W, Saya H, et al.
- Journal Title
  
  Int J Cancer
  
  Volume: 129 Pages: 34-44
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650229
[Journal Article] PSF1, a DNA replication factor expressed widely in stem and progenitor cells, drives tumorigenic and metastatic properties2010
- Author(s)
  Nagahama Y, Ueno M, Miyamoto S, Morii E, Minami T, Mochizuki N, Saya H, Takakura N
- Journal Title
  
  Cancer Res
  
  Volume: 70(3) Pages: 1215-24
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Mad2 targets the mitotic kinesin MKlp2 and inhibits its kinesin function required for cytokinesis.2010
- Author(s)
  Lee SH, Saya H et al
- Journal Title
  
  J Cell Biol
  
  Volume: 191 Pages: 1069-1077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010
- Author(s)
  Naoe H, Araki K, Nagano O, Kobayashi Y, Ishizawa J, Chiyoda T, Shimizu T, Yamamura K, Sasaki Y, Saya H, Kuninaka S
- Journal Title
  
  Mol Cell Biol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells2010
- Author(s)
  Shinoe T, Kuribayashi H, Saya H, Seiki M, Aburatani H, Watanabe S
- Journal Title
  
  J Neurochem
  
  Volume: 115(6) Pages: 1633-42
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Experimental therapies : Investigator-initiated cancer trials with INDs for approval in Japan2010
- Author(s)
  Imamura CK, Takebe N, Nakamura S, Saya H, Ueno NT
- Journal Title
  
  Nat Rev Clin Oncol
  
  Volume: 7(3) Pages: 127-8
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 12010
- Author(s)
  Arima Y, Hayashi H, Kamata K, Goto TM, Sasaki M, Kuramochi A, Saya H
- Journal Title
  
  Exp Dermatol
  
  Volume: 19(8)
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Proteome profiling reveals gender differences in the composition of human serum2010
- Author(s)
  Miike K, Aoki M, Yamashita R, Takegawa Y, Saya H, Miike T, Yamamura K
- Journal Title
  
  Proteomics
  
  Volume: 10(14) Pages: 2678-91
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.2010
- Author(s)
  Shimizu T, Saya H, et al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 5687-5699
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells.2010
- Author(s)
  Shinoe T, Saya H, et al.
- Journal Title
  
  J Neurochem
  
  Volume: 115 Pages: 1633-1642
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] Decreased expression of neurofibromin contributes to epithelial-mesenchymal transition in neurofibromatosis type 1 (NF1).2010
- Author(s)
  Arima Y, Saya H, et al.
- Journal Title
  
  Exp Dermatol
  
  Volume: 19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650229
[Journal Article] NKX2.2 suppresses self-renewal of glioma-initiating cells.2010
- Author(s)
  Muraguchi T, Saya H et al.
- Journal Title
  
  Cancer Res
  
  Volume: 71 Pages: 1135-1145
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Breast cancer stem cells2010
- Author(s)
  Kai K, Arima Y, Kamiya T, Saya H
- Journal Title
  
  Breast Cancer
  
  Volume: 17(2) Pages: 80-5
- NAID
  10027255296
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells2010
- Author(s)
  Tajima K, Ohashi R, Sekido Y, Hida T, Nara T, Hashimoto M, Iwakami S, Minakata K, Yae T, Takahashi F, Saya H, Takahashi K
- Journal Title
  
  Oncogene
  
  Volume: 29(13) Pages: 1941-51
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Myristoylated alanine-rich C kinase substrate phosphorylation promotes cholangiocarcinoma cell migration and metastasis via the protein kinase C-dependent pathway2010
- Author(s)
  Techasen A, Loilome W, Namwat N, Takahashi E, Sugihara E, Puapairoj A, Miwa M, Saya H, Yongvanit P
- Journal Title
  
  Cancer Sci
  
  Volume: 101(3) Pages: 658-65
- NAID
  10026589391
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis2010
- Author(s)
  Ishimoto T, Oshima H, Oshima M, Kai K, Torii R, Masuko T, Baba H, Saya H, Nagano O
- Journal Title
  
  Cancer Sci
  
  Volume: 101(3) Pages: 673-8
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Mad2 targets the mitotic kinesin Mk1-p2 and inhibits its kinesin function required for cytokinesis.2010
- Author(s)
  Lee SH, Saya H, et al.
- Journal Title
  
  J Cell Biol
  
  Volume: 191 Pages: 1069-1077
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Osteopontin-mediated enhanced hyaluronan binding induces multidrug resistance in mesothelioma cells.2010
- Author(s)
  Tajima K, Saya H, et al.
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 1941-1951
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650229
[Journal Article] Tumor necrosis factor-alpha regulates transforming growth factor-beta-dependent epithelial-mesenchymal transition by promoting hyaluronan-CD 44-moesin interaction2010
- Author(s)
  Takahashi E, Nagano O, Ishimoto T, Yae T, Suzuki Y, Shinoda T, Nakamura S, Niwa S, Ikeda S, Koga H, Tanihara H, Saya H
- Journal Title
  
  J Biol Chem
  
  Volume: 285(6) Pages: 4060-73
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Identification of CD44 as a cell surface marker for Muller glia precursor cells.2010
- Author(s)
  Shinoe T, Saya H et al
- Journal Title
  
  J Neurochem
  
  Volume: 115 Pages: 1633-1642
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] The APC/C activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.2010
- Author(s)
  Naoe H, Saya H, et al.
- Journal Title
  
  Mol Cell Biol
  
  Volume: 30 Pages: 3994-4005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650229
[Journal Article] MARCKS phosphorylation promotes cholangiocarcinoma cell migration and metastasis via PKC-dependent pathway.2010
- Author(s)
  Techasen A, Saya H, et al.
- Journal Title
  
  Cancer Sci
  
  Volume: 101 Pages: 655-665
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22650229
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis.2010
- Author(s)
  Shimizu T, Saya H et al
- Journal Title
  
  Oncogene
  
  Volume: 29 Pages: 5687-5699
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249055
[Journal Article] Mad2 targets the mitotic kinesin MKlp2 and inhibits its kinesin function required for cytokinesis.2010
- Author(s)
  Lee SH, Saya H, et al.
- Journal Title
  
  J Cell Biol
  
  Volume: 191 Pages: 1069-1077
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130007
[Journal Article] c-MYC overexpression with loss of Ink4a/Arf transforms bone marrow stromal cells into osteosarcoma accompanied by loss of adipogenesis2010
- Author(s)
  Shimizu T, Ishikawa T, Sugihara E, Kuninaka S, Miyamoto T, Mabuchi Y, Matsuzaki Y, Tsunoda T, Miya F, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Kawai A, Ichikawa H, Hasegawa T, Okada S, Ito T, Ikeda Y, Suda T, Saya H
- Journal Title
  
  Oncogene
  
  Volume: 29(42) Pages: 5687-99
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Mad2 inhibits the mitotic kinesin MKlp22010
- Author(s)
  Lee SH, McCormick F, Saya H
- Journal Title
  
  J Cell Biol
  
  Volume: 191(6) Pages: 1069-77
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] An essential role of the aPKC-Aurora A-NDEL1 pathway on neurite elongation by modulation of microtubule dynamics.2009
- Author(s)
  Mori D, Yamada M, Mimori-Kiyosue Y, Shirai Y, Suzuki A, Ohno S, Saya H, Wynshaw-Boris A, Hirotsune S
- Journal Title
  
  Nat Cell Biol 11
  
  Pages: 1057-1068
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Reversible whole-organism cell cycle arrest in a living vertebrate.2009
- Author(s)
  Sampetrean O, Iida S, Makino S, Matsuzaki Y, Ohno K, Saya H
- Journal Title
  
  Cell Cycle 8
  
  Pages: 620-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] 抗癌剤効果の分子機構2009
- Author(s)
  佐谷秀行
- Journal Title
  
  癌と化学療法(癌と化学療法社) 36
  
  Pages: 1-5
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis2009
- Author(s)
  Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and Suda T
- Journal Title
  
  J Exp Med 206
  
  Pages: 1089-1102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells.2009
- Author(s)
  Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H, Yamashita Y
- Journal Title
  
  Cancer Res 69
  
  Pages: 3901-3909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] K858, a novel inhibitor of mitotic kinesin Eg5 and antitumor agent, induces cell death in cancer cells2009
- Author(s)
  Nakai R, Iida S, Takahashi T, Tsujita T, Okamoto S, Takada C, Akasaka K, Ichikawa S, Ishida H, Kusaka H, Akinaga S, Murakata C, Honda S, Nitta M, Saya H and Yamashita Y
- Journal Title
  
  Cancer Res 69
  
  Pages: 3901-3909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Reversible whole-organism cell cycle arrest in a living vertebrate2009
- Author(s)
  Sampetrean O, Iida S, Makino S, Matsuzaki Y, Ohno K and Saya H
- Journal Title
  
  Cell Cycle 8
  
  Pages: 620-627
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Molecular mechanisms regulating dissociation of cell-cell junction of epithelial cells by oxidative stress2009
- Author(s)
  Inumaru J, Nagano O, Takahashi E, Ishimoto T, Nakamura S, Suzuki Y, NiwaSI, Umezawa K, Tanihara H and Saya H
- Journal Title
  
  Genes Cells(Epub ahead of print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Activated macrophages promote Wnt signaling through tumor necrosis factor- in gastric tumor cells2008
- Author(s)
  Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM and Oshima M
- Journal Title
  
  EMBO J 27
  
  Pages: 1671-1681
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] HBV X protein targets hBubR1, which induces dysregulation of the mitotic checkpoint2008
- Author(s)
  Kim S, Park SY, Yong H, Famulski JK, Chae S, Lee JH, Kang CM, Saya H, Chan GK, and Cho H
- Journal Title
  
  Oncogene 27
  
  Pages: 3457-3464
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] NF1 tumor suppressor, neurofibromin, regulates the neuronal differentiation of PC12 cells via its associating protein,collapsin response mediator protein-22008
- Author(s)
  Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H and Araki N
- Journal Title
  
  J Biol Chem 283
  
  Pages: 9399-9413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] p53 regulates TLR3 expression and function in human epithelial cell lines2008
- Author(s)
  Taura M, Eguma A, Suico MA, Shuto T, Koga T, Komatsu K, Komune T, Sato T, Saya H, Li JD and Kai H
- Journal Title
  
  Mol Cell Biol 28
  
  Pages: 6557-6567
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Aurora-Aの発がんにおける役割2008
- Author(s)
  張東威、佐谷秀行
- Journal Title
  
  実験医学増刊「シグナル伝達研究2008-'09」(羊土社) 26
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice.2008
- Author(s)
  Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M, Saya H
- Journal Title
  
  Oncogene 27
  
  Pages: 4305-4314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice2008
- Author(s)
  Zhang D, Shimizu T, Araki N, Hirota T, Yoshie M, Ogawa K, Nakagata N, Takeya M and Saya H
- Journal Title
  
  Oncogene 27
  
  Pages: 4305-4314
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Aurora-A overexpression induces cellular senescence in mammary gland hyperplastic tumors developed in p53-deficient mice2008
- Author(s)
  D. Zhang, T. Shimizu, N. Araki, T. Hirota, M. Yoshie, K. Ogawa, N. Nakagata, M. Takeya, H. Saya
- Journal Title
  
  Oncogene 27
  
  Pages: 4305-4314
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Neurofibromatosis Type I tumor suppressor, neurofibromin, regulates the neurite outgrowth of PC12 cells via its associating protein, CRMP-22008
- Author(s)
  Patrakitkomjorn S, Kobayashi D, Morikawa T, Wilson MM, Tsubota N, Irie A, Ozawa T, Aoki M, Arimura N, Kaibuchi K, Saya H, Araki N
- Journal Title
  
  J. Biol. Chem 283(14)
  
  Pages: 9399-413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390382
[Journal Article] Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristics of the epithelial to mesenchymal transition2008
- Author(s)
  Arima Y, Inoue Y, Shibata T, Hayashi H, Nagano O, Saya H and Taya Y
- Journal Title
  
  Cancer Res 68
  
  Pages: 5104-5112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] AIP regulates stability of Aurora-A at early mitotic phase coordinately with GSK-32008
- Author(s)
  Fumoto K, Lee PC, Saya H and Kikuchi A
- Journal Title
  
  Oncogene 27
  
  Pages: 4478-4487
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Auroraキナーゼの機能と発がんにおける役割。2007
- Author(s)
  佐谷秀行
- Journal Title
  
  生化学 79
  
  Pages: 131-139
- NAID
  10018733578
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Auroraキナーゼの機能と発がんにおける役割2007
- Author(s)
  佐谷秀行
- Journal Title
  
  日本生化学会 79
  
  Pages: 131-139
- NAID
  10018733578
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation.2007
- Author(s)
  Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S, Saya H
- Journal Title
  
  Oncogene 26
  
  Pages: 2395-2406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Auroraキナーゼの機能と発がんにおける役割。2007
- Author(s)
  佐谷秀行
- Journal Title
  
  生化学 79
  
  Pages: 131-139
- NAID
  10018733578
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17209049
[Journal Article] auroraキナーゼの機能と発がんにおける役割。2007
- Author(s)
  佐谷秀行
- Journal Title
  
  生化学 79
  
  Pages: 131-139
- NAID
  10018733578
- Data Source
  KAKENHI-PROJECT-17209049
[Journal Article] Auroraキナーゼの機能と発がんにおける役割。2007
- Author(s)
  佐谷秀行
- Journal Title
  
  生化学 79
  
  Pages: 131-139
- NAID
  10018733578
- Data Source
  KAKENHI-PROJECT-18659089
[Journal Article] Aurora kinase : Functions and roles in tumorigenesis2007
- Author(s)
  Saya H
- Journal Title
  
  J. Biochemistry 79
  
  Pages: 131-139
- NAID
  10018733578
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17209049
[Journal Article] Wynshaw-Boris A and Hirotsune S. NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation,separation, and TACC3 recruitment2007
- Author(s)
  Mori D, Yano Y, Toyo-oka K, Yoshida N, Yamada M, Muramatsu M, Zhang D, Saya H, Toyoshima YY, Kinoshita K
- Journal Title
  
  Mol Cell Biol 27
  
  Pages: 352-367
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Visualizing the dynamics of p21^<Waf1/Cip1> cyclin-dependent kinase inhibitor expression in living animals2007
- Author(s)
  Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N and Hara E
- Journal Title
  
  Proc Natl Acad Sci USA 104
  
  Pages: 15034-15039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] Serine protease Omi/HtrA2 targets WARTS kinase to control cell proliferation2007
- Author(s)
  Kuninaka S, Iida S, Hara T, Nomura M, Naoe H, Morisaki T, Nitta M, Arima Y, Mimori T, Yonehara S and Saya H
- Journal Title
  
  Oncogene 26
  
  Pages: 2395-2406
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19209048
[Journal Article] WARTSキナーゼを介した器官サイズ制御と発癌抑制の接点2006
- Author(s)
  國仲慎治、佐谷秀行
- Journal Title
  
  実験医学 24
  
  Pages: 1610-1615
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18590300
[Journal Article] Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.2006
- Author(s)
  Takahashi A, Ohtani N, Yamakoshi K, Iida S, Tahara H, Nakayama K, Nakayama KI, Ide T, Saya H, Hara E
- Journal Title
  
  Nat Cell Biol 8
  
  Pages: 1291-1297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Organ size control mediated by WARTS kinase play a role in tumor suppression2006
- Author(s)
  Shinji, Kuninaka, Hideyuki, Saya
- Journal Title
  
  Experimental Medicine 24-11
  
  Pages: 1610-1615
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590300
[Journal Article] 癌におけるゲノム不安定性2005
- Author(s)
  有馬好美、佐谷秀行
- Journal Title
  
  ゲノム医学(メディカルレビュー社) 5
  
  Pages: 115-119
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Aurora A - A guardian of poles.2005
- Author(s)
  Marumoto T, Zhang D, Saya H
- Journal Title
  
  Nat Rev Cancer 5
  
  Pages: 42-50
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Observation of the Intracellular Behavior of Recombinant Yersinia pseudotuberculosis Invasin Protein.2005
- Author(s)
  Koga H, Izawa I, Araki N, Saya H, Mimori T.
- Journal Title
  
  Microbiol Immunol. 49(4)
  
  Pages: 297-302
- NAID
  10015527670
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390413
[Journal Article] 細胞分裂とその制御2005
- Author(s)
  佐谷秀行
- Journal Title
  
  分子細胞治療(特集監修, 先端医学社) 4
  
  Pages: 465-466
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] The neurofibromatosis type 1 gene product neurofibromin enhances cell motility by regulating actin filament dynamics via the Rho-ROCK-LIMK2-cofilin pathway.2005
- Author(s)
  Ozawa T, Araki N, Yunoue S, Tokuo H, Feng L, Patrakitkomjom S, Hara T, Ichikawa Y, Matsumoto K, Fujii K, Saya H
- Journal Title
  
  J Biol Chem 280
  
  Pages: 39524-39533
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390413
[Journal Article] Aurora A - A guardian of poles2005
- Author(s)
  T. Marumoto, D. Zhang, H. Saya
- Journal Title
  
  Nat. Rev. Cancer 5
  
  Pages: 42-50
- Data Source
  KAKENHI-PROJECT-16059101
[Journal Article] Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.2005
- Author(s)
  Sasayama, T. et al.
- Journal Title
  
  Genes To Cells 10
  
  Pages: 627-638
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] The tumor suppressor WARTS activates the Omi/HtrA2-dependent pathway of cell death.2005
- Author(s)
  Kuninaka S, Nomura M, Hirota T, Iida S, Hara T, Honda S, Kunitoku N, Sasayama T, Arima Y, Marumoto T, Koja K, Yonehara S, Saya H
- Journal Title
  
  Oncogene 24
  
  Pages: 5287-5298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B1.2005
- Author(s)
  Sasayama, T. et al.
- Journal Title
  
  Genes To Cells 10
  
  Pages: 627-638
- Data Source
  KAKENHI-PROJECT-17209049
[Journal Article] Transcriptional blockade induces p53-dependent apoptosis associated with translocation of p53 to mitochondria.2005
- Author(s)
  Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y, Nakao M, Saya H
- Journal Title
  
  J Biol Chem 280
  
  Pages: 19166-19176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17013070
[Journal Article] Overexpression of Aurora-A targets cytoplasmic polyadenylation element binding protein and promotes mRNA polyadenylation of Cdk1 and cyclin B12005
- Author(s)
  Sasayama, T. et al.
- Journal Title
  
  Genes To Cells 10
  
  Pages: 627-638
- Data Source
  KAKENHI-PROJECT-17659096
[Journal Article] PKA phosphorylation and 14-3-3 interaction regulate the function of neurofibromatosis type I tumor suppressor, neurofibromin.2004
- Author(s)
  Feng L, Yunoue S, Tokuo H, Ozawa T, Zhang D, Patrakitkomjorn S, Ichimura T, Saya H, Araki N^*.
- Journal Title
  
  FEBS Lett. 557(1-3)
  
  Pages: 275-282
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390413
[Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress
- Author(s)
  Ishizawa J, Kuninaka S, Sugihara E, Naoe H, Kobayashi Y, Chiyoda T, Ueki A, Araki K, Yamamura KI, Matsuzaki Y, Nakajima H, Ikeda Y, Okamoto S, Saya H
- Journal Title
  
  Cancer Sci.
  
  Volume: (in press)
- NAID
  10029293305
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Patent] がん幹細胞の増殖抑制剤および細胞内活性酸素蓄積誘導剤2014
- Inventor(s)
  永野修、佐谷秀行、岡崎章悟
- Industrial Property Rights Holder
  永野修、佐谷秀行、岡崎章悟
- Industrial Property Rights Type
  特許
- Filing Date
  2014-01-29
- Data Source
  KAKENHI-PLANNED-22130007
[Patent] 抗腫瘍剤2011
- Inventor(s)
  佐谷秀行、永野修、益子高、丹羽眞一郎
- Industrial Property Rights Holder
  学校法人慶應義塾、学校法人近畿大学、リンク・ジェノミクス(株)
- Filing Date
  2011-01-13
- Data Source
  KAKENHI-PLANNED-22130007
[Patent] In vitro Fibrotic Focusモデル及び、それを用いた治療薬評価システム2007
- Inventor(s)
  佐谷秀行、永野修、丹羽真一郎、中村賢志、鈴木良美
- Industrial Property Rights Holder
  学校法人慶慮義塾、リンク・ジェノミクス株式会社
- Industrial Property Number
  2007-209591
- Filing Date
  2007-08-10
- Data Source
  KAKENHI-PROJECT-19209048
[Patent] in vitro Fibrotic Focus モデル及び、それを用いた治療薬評価システム2007
- Inventor(s)
  佐谷秀行、永野修、丹羽眞一郎、中村賢志、鈴木良美
- Industrial Property Rights Holder
  学校法人慶應義塾、リンク・ジェノミクス(株)
- Industrial Property Number
  2007-209591
- Filing Date
  2007-08-10
- Data Source
  KAKENHI-PROJECT-19209048
[Patent] In vitro Fibrotic Focusモデル及び、それを用いた治療薬評価システム2007
- Inventor(s)
  佐谷秀行、永野修、丹羽眞一郎、中村賢志、鈴木良美
- Industrial Property Rights Holder
  学校法人慶應義塾、リンク・ジェノミクス株式会社
- Industrial Property Number
  2007-209591
- Filing Date
  2007-08-10
- Data Source
  KAKENHI-PROJECT-17013070
[Patent] 細胞周期作用物質2005
- Inventor(s)
  佐谷秀行他2名
- Industrial Property Rights Holder
  熊本大学, リンク・ジェノミクスKK
- Industrial Property Number
  2005-115926
- Filing Date
  2005-04-13
- Data Source
  KAKENHI-PROJECT-17013070
[Patent] 細胞周期作用物質2005
- Inventor(s)
  佐谷秀行, 他2名
- Industrial Property Rights Holder
  熊本大学, リンク・ジェノミクスKK.
- Industrial Property Number
  2005-115926
- Filing Date
  2005-04-13
- Data Source
  KAKENHI-PROJECT-17209049
[Patent] 細胞周期作用物質2005
- Inventor(s)
  佐谷秀行, 他2名
- Industrial Property Rights Holder
  熊本大学, リンク・ジェノミクスKK
- Industrial Property Number
  2005-115926
- Filing Date
  2005-04-13
- Data Source
  KAKENHI-PROJECT-17659096
[Presentation] 舌に発生した紡錘細胞癌は間葉系幹細胞の性質をもつ2019
- Author(s)
  吉川桃子、黄地健仁、森川暁、高橋萌、相馬智也、宮下英高、河奈裕正、佐谷秀行、中川種昭、莇生田整治
- Organizer
  第64回　日本口腔外科学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-19K10344
[Presentation] Role of actin dynamics in cell fate plasticity of microenvironmental cells2019
- Author(s)
  Hideyuki Saya
- Organizer
  11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research: Biology to Precision Medicine
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01401
[Presentation] Benzaldehydeは腫瘍細胞における14-3-3ζ;の高発現を介してAMPK活性を亢進させる2019
- Author(s)
  齋藤潤、大西伸幸、杉原英志、岡崎章悟、信末博行、笠間隆志、佐谷秀行
- Organizer
  第78回日本癌学会総会
- Data Source
  KAKENHI-PROJECT-19K22568
[Presentation] 口腔に発生した再発紡錘細胞癌における間葉系幹細胞の同定2019
- Author(s)
  吉川桃子、黄地健仁、森川暁、芝田晋介、高橋萌、相馬智也、宮下英高、村岡渡、亀山香織、河奈裕正、有馬好美、佐谷秀行、岡野栄之、中川種昭、莇生田整治
- Organizer
  第43回　日本頭頸部癌学会
- Data Source
  KAKENHI-PROJECT-19K10344
[Presentation] 口腔扁平上皮癌を含めたがん幹細胞について基礎からトレンドまで2016
- Author(s)
  佐谷秀行
- Organizer
  （公社）日本口腔外科学会第45回教育研修会（2016 年口腔四学会合同研修会）
- Place of Presentation
  鶴見大学記念館（神奈川県横浜市）
- Year and Date
  2016-02-27
- Invited
- Data Source
  KAKENHI-PROJECT-25462930
[Presentation] がん幹細胞を標的とする新たながん治療開発の展望2015
- Author(s)
  佐谷秀行
- Organizer
  第53回日本癌治療学会学術集会
- Place of Presentation
  国立京都国際会館（京都府左京区）
- Year and Date
  2015-10-29
- Invited
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] 腫瘍組織の不均一性に基づく治療抵抗性とその治療戦略2015
- Author(s)
  佐谷秀行
- Organizer
  第29回中国四国脳腫瘍研究会
- Place of Presentation
  愛媛県県民文化会館（愛媛県松山市）
- Year and Date
  2015-09-04
- Invited
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] がん幹細胞を標的とした治療戦略2015
- Author(s)
  佐谷秀行
- Organizer
  第56回日本臨床細胞学会総会春期大会
- Place of Presentation
  くにびきメッセ/松江テルサ（島根県松江市）
- Year and Date
  2015-06-13
- Invited
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] New mouse model for mature B cell lymphoma revealing requirement for Fas downregulation in lymphomagenesis.2015
- Author(s)
  Sugihara E, Hashimoto N, Ueno S, Saya H
- Organizer
  20th Congress of European Hematology Association
- Place of Presentation
  Vienna, Austria.
- Year and Date
  2015-06-11
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] New mouse lymphoma model reveals the requirement for Fas downregulation in initiation and maintenance of lymphoma cells2015
- Author(s)
  杉原英志、橋本典愉、植野さやか、清水孝恒、佐谷秀行
- Organizer
  第74回日本癌学会総会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] セツキシマブ耐性口腔扁平上皮癌細胞に対する治療の可能性2015
- Author(s)
  吉川桃子, 莇生田整治, 森川暁, 宮下英高, 臼田慎, 河奈裕正, 中川種昭, 佐谷秀行, 永野修
- Organizer
  第33回日本口腔腫瘍学会総会
- Place of Presentation
  奈良
- Year and Date
  2015-01-30
- Data Source
  KAKENHI-PROJECT-25462930
[Presentation] がん幹細胞の特性解析と標的治療2015
- Author(s)
  佐谷秀行
- Organizer
  第13回日本臨床腫瘍学会学術集会
- Place of Presentation
  札幌市教育文化会館（北海道札幌市）
- Year and Date
  2015-07-16
- Invited
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] Heterogeneity and plasticity of cancer metabolism2015
- Author(s)
  Saya H
- Organizer
  74th Annual Meeting of Japanese Cancer Association
- Place of Presentation
  Nagoya Congress Center (Aichi Prefecture, Nagoya)
- Year and Date
  2015-10-08
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] がん幹細胞を標的とした治療戦略2015
- Author(s)
  佐谷秀行
- Organizer
  第25回日本サイトメトリー学会学術集会
- Place of Presentation
  ソラシティーカンファレンスセンター（東京都千代田区）
- Year and Date
  2015-07-11
- Invited
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] 脳腫瘍の病態と未来の癌治療2015
- Author(s)
  佐谷秀行
- Organizer
  第18回日本臨床脳神経外科学会
- Place of Presentation
  ホテルオークラ神戸（兵庫県神戸市）
- Year and Date
  2015-07-19
- Invited
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] Therapeutic strategies targeting cancer stem cells2015
- Author(s)
  Saya H
- Organizer
  The 3rd Beijing International Symposium on Tumor Microenvironment
- Place of Presentation
  Beijing (China)
- Year and Date
  2015-05-17
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] Novel mouse model for mature B cell lymphoma reveals the requirement for Fas downregulation in lymphomagenesis.2015
- Author(s)
  Sugihara E, Hashimoto N, Ueno S, Saya H
- Organizer
  American Association for Cancer Research Annual meeting
- Place of Presentation
  Philadelphia, USA.
- Year and Date
  2015-04-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] がん幹細胞の代謝不均一性2015
- Author(s)
  佐谷秀行
- Organizer
  第13回日本プロテオーム学会
- Place of Presentation
  くまもと森都心プラザ（熊本県熊本市）
- Year and Date
  2015-07-23
- Invited
- Data Source
  KAKENHI-PROJECT-15K14384
[Presentation] 骨肉腫幹細胞の性状解析と分化制御による治療戦略の考案2014
- Author(s)
  佐谷秀行
- Organizer
  第56回日本小児血液・がん学会学術集会
- Place of Presentation
  岡山コンベンションセンター、岡山
- Year and Date
  2014-11-29
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] 薬剤スクリーニングに用いる癌遺伝子HRAS導入メダカモデルの確立2014
- Author(s)
  松崎ゆり子・佐谷秀行
- Organizer
  日本癌学会
- Place of Presentation
  神奈川・パシフィコ横浜
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-24591633
[Presentation] がん幹細胞を標的とした治療戦略2014
- Author(s)
  佐谷秀行
- Organizer
  第18回日本がん分子標的治療学会学術集会
- Place of Presentation
  ホテルメトロポリタン仙台、仙台
- Year and Date
  2014-06-25
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] CD44v9 results in resistance to trastuzumab via induction of ROS resistance2014
- Author(s)
  Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
- Organizer
  Digestive Disease Week 2014
- Place of Presentation
  Chicago, USA
- Year and Date
  2014-05-03
- Data Source
  KAKENHI-PROJECT-25293178
[Presentation] Establishment of transgenic HRAS medaka as a tumor model for in vivo drug screening2014
- Author(s)
  松崎ゆり子・佐谷秀行他
- Organizer
  小型魚類研究会
- Place of Presentation
  慶應義塾大学薬学部
- Year and Date
  2014-09-20
- Data Source
  KAKENHI-PROJECT-24591633
[Presentation] がん幹細胞の代謝特性2014
- Author(s)
  佐谷　秀行
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2014-11-26
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] 脳腫瘍幹細胞の性状解析に基づく治療戦略の考案2014
- Author(s)
  佐谷　秀行
- Organizer
  第32回脳腫瘍病理学会
- Place of Presentation
  徳島県徳島市
- Year and Date
  2014-05-24
- Invited
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] Mechanisms of adaptive radioprotection in glioma stem cells2014
- Author(s)
  Hideyuki Saya
- Organizer
  20th International Conference on Brain Tumor Research and Therapy
- Place of Presentation
  Lake Tahoe, USA
- Year and Date
  2014-07-21
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] Therapeutic strategies for targeting cancer stem cells.2013
- Author(s)
  佐谷秀行
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] Novel therapeutic strategies for cancer stem cells.2013
- Author(s)
  Hideyuki Saya
- Organizer
  The 39th Annual Meeting of Korean Cancer Association.
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] CD44 and gastric epithelial stem cells.2013
- Author(s)
  Hideyuki Saya
- Organizer
  6th Annual Scientific Meeting, Singapore Gastric Cancer Consortium.
- Place of Presentation
  Singapore
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] 口腔癌細胞の腫瘍形成におけるCD44v-xCTの機能的役割2013
- Author(s)
  吉川桃子, 永野修, 莇生田整治, 中川種昭, 河奈裕正, 佐谷秀行
- Organizer
  第31回日本口腔腫瘍学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-22592100
[Presentation] がん幹細胞マーカーCD44とPKM2の相互作用を介した糖代謝制御2013
- Author(s)
  玉田真由美、末松誠、佐谷秀行
- Organizer
  第１回がんと代謝研究会
- Place of Presentation
  鶴岡メタボロームキャンパスレクチャーホール（山形県）
- Data Source
  KAKENHI-PROJECT-25870717
[Presentation] Novel strategies for targeting cancer stem cells.2013
- Author(s)
  Saya H
- Organizer
  Ninth AACR-Japanes Cancer Association Joint Conference
- Place of Presentation
  Hawaii，米国
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] Invasive and radio-resistant characteristics of glioma stem cells2013
- Author(s)
  Saya H
- Organizer
  10th Asian Society for NeuroOncology (ASNO) Conference
- Place of Presentation
  Mumbai, India
- Invited
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] Modulation of glucose metabolism by CD44 contributes to antioxidant status and drug resistance in cancer cells2013
- Author(s)
  Mayumi Tamada, Makoto Suematsu, Hideyuki Saya
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington Convention Center
- Data Source
  KAKENHI-PROJECT-25870717
[Presentation] Roles of CD44 in cancer stem cells.2013
- Author(s)
  Hideyuki Saya
- Organizer
  The American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington DC, USA
- Invited
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] Characterization of brain tumor stem cells using induced cancer stem cell (iCSC) technology.2012
- Author(s)
  Saya H
- Organizer
  Invited Lecture, Korean Neuro-Oncology Meeting.
- Place of Presentation
  Gyeonggi-do, Korea
- Year and Date
  2012-09-22
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] xCT シスチントランスポーターの阻害はCD44 バリアント陽性扁平上皮癌細胞の生体内における拡大を抑制する.2012
- Author(s)
  吉川桃子, 永野修, 土橋賢治, 莇生田整治, 中川種昭, 佐谷秀行
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22592100
[Presentation] Invasive and radio-resistant characteristics of glioma stem cells2012
- Author(s)
  Saya H
- Organizer
  10th Asian Society for NeuroOncology (ASNO)conference
- Place of Presentation
  Mumbai, India
- Year and Date
  2012-03-22
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] A novel therapeutic approach targeting the CD44 variant functions.2012
- Author(s)
  Saya H
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] Characterization of brain tumor stem cells using induced cancer stem cell (iCSC) technology2012
- Author(s)
  Saya H
- Organizer
  Korean Neuro-Oncology Meeting
- Place of Presentation
  Gyeonggi-do, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] シーズ探索その1「大学における基礎研究を創薬に結び付けるために」2012
- Author(s)
  佐谷秀行
- Organizer
  第12回抗悪性腫瘍開発フォーラム
- Place of Presentation
  東京都、吉田富三記念講堂、がん研究会がん研究所
- Year and Date
  2012-02-18
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] Role of CD44 in cancer stem cells and metastasis2011
- Author(s)
  Saya H
- Organizer
  8^<th> International Symposium on Minmal Residual Cancer
- Place of Presentation
  Osaka International Convention Center, Osaka(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] 悪性脳腫瘍幹細胞の浸潤能の解析2011
- Author(s)
  サンペトラオルテア、佐谷秀行
- Organizer
  第29回日本脳腫瘍学会
- Place of Presentation
  下呂温泉水明館(岐阜)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] Role of CD44 in Cancer Stem Cells.2011
- Author(s)
  Saya H
- Organizer
  The 29^<th> Nagoya International Cancer Treatment Symposium.
- Place of Presentation
  愛知がんセンター(愛知県)
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PROJECT-22650229
[Presentation] Role of CD44 in cancer stem cells and metastasis. Prenary Lecture52011
- Author(s)
  Saya H
- Organizer
  8^<th> International Symposium on Residual Cancer
- Place of Presentation
  Osaka
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23650601
[Presentation] HRAS^<G12V> transgenic medaka fish develop melanoma with high frequency2011
- Author(s)
  松崎ゆり子, 佐谷秀行, 他
- Organizer
  The 1^<st> strategic meeting for medaka research
- Place of Presentation
  愛知県: Okazaki conference center
- Year and Date
  2011-11-23
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] がん幹細胞の治療抵抗性メカニズム2011
- Author(s)
  佐谷秀行
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知県:名古屋国際会議場
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] New strategies in glioblastoma treatment-insights from the induced cancer stem cell (iCSC) model2011
- Author(s)
  Sampetrean O, Saya H
- Organizer
  Taipei VGH and NYMU Brain Tumor Symposium 2011
- Place of Presentation
  Taipei, Taiwan(招待講演)
- Year and Date
  2011-11-30
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] グリオーマ幹細胞モデルを用いた薬剤抵抗性克服2011
- Author(s)
  サンペトラオルテア、佐谷秀行
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場(愛知県名古屋市)
- Year and Date
  2011-10-03
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] 癌幹細胞の治療抵抗性を制御する分子機構。パネルディスカッション3「がん幹細胞研究の進展と治療展開」2011
- Author(s)
  佐谷秀行
- Organizer
  第49回日本癌治療学会学術集会
- Place of Presentation
  愛知県、名古屋国際会議場
- Year and Date
  2011-10-27
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] Role of CD44 in Cancer Stem Cells.2011
- Author(s)
  Saya H
- Organizer
  The 29^<th> Nagoya International Cancer Treatment Symposium.
- Place of Presentation
  愛知がんセンター(愛知県)
- Year and Date
  2011-02-11
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] がん幹細胞の性質を制御する分子機構とその治療戦略2011
- Author(s)
  佐谷秀行
- Organizer
  CBI学会第316回研究講演会
- Place of Presentation
  東京都、総評会館
- Year and Date
  2011-04-18
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] Role of CD44 in cancer stem cells and metastasis2011
- Author(s)
  Saya H
- Organizer
  8^<th> International Symposium on Minmal Residual Cancer
- Place of Presentation
  Osaka International Convention Center, Osaka
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-ORGANIZER-22130001
[Presentation] Role of CD44 in cancer stem cells and metastasis2011
- Author(s)
  Saya H
- Organizer
  Plenary Lecture 5, 8^<th> International Symposium on Minmal Residual Cancer
- Place of Presentation
  Osaka International Convention Center, Osaka(招待講演)
- Year and Date
  2011-09-23
- Data Source
  KAKENHI-PROJECT-23650601
[Presentation] HRAS^<G12V> transgenic medaka fish develop melanoma with high frequency2011
- Author(s)
  松崎ゆり子, 佐谷秀行
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  愛知県:名古屋国際会議場
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] メダカ悪性黒色腫モデル系の構築2010
- Author(s)
  松崎ゆり子, 佐谷秀行, 他
- Organizer
  第16回小型魚類研究会
- Place of Presentation
  埼玉県:プラザイースト
- Year and Date
  2010-09-19
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] New melanoma model using transgenic medaka fish2010
- Author(s)
  松崎ゆり子, 佐谷秀行, 他
- Organizer
  日本分子生物学会年会
- Place of Presentation
  兵庫県:神戸国際会議場
- Year and Date
  2010-12-09
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] 動物モデルを用いた癌幹細胞の性状解析2010
- Author(s)
  佐谷秀行
- Organizer
  第19回泌尿器科分子・細胞研究会
- Place of Presentation
  神戸ポートピアホテル
- Year and Date
  2010-02-20
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Novel Strategy for Glioma Invasion.2010
- Author(s)
  Saya H
- Organizer
  7^<th> Meeting of Asian Society for Neuro-Oncology (ASNO).
- Place of Presentation
  JW Marriott Hotel (Seoul, Korea)
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-22650229
[Presentation] Role of CD44 hyaluronan receptor in cancer stem cells.2010
- Author(s)
  Saya H
- Organizer
  8^<th> International Conference on Hyaluronan.The International Society for Hyaluronan Sciences(ISHAS).
- Place of Presentation
  京都ブライトンホテル
- Year and Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] Role of CD44 hyaluronan receptor in cancer stem cells2010
- Author(s)
  Saya H
- Organizer
  8th International Conference on Hyaluronan. The International Society for Hyaluronan Sciences (ISHAS)
- Place of Presentation
  Kyoto
- Year and Date
  2010-06-09
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] 誘導型がん幹細胞の解析と応用2010
- Author(s)
  佐谷秀行
- Organizer
  第51回日本臨床細胞学会総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2010-05-31
- Data Source
  KAKENHI-PROJECT-22249055
[Presentation] Significance of epithelial mesenchymal transition (EMT) in cancer malignancy.2010
- Author(s)
  Hideyuki Saya
- Organizer
  6^<th> Annual Conference of OOTR.
- Place of Presentation
  The Westin Miyako Hotel
- Year and Date
  2010-02-06
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Drug Development for Cancer Cell Migration.2009
- Author(s)
  Hideyuki Saya
- Organizer
  The International Symposium of Pediatric Neuro-oncology for the 50th Anniversary of Taipei Veterans General Hospital and the Annual Scientific Meeting of Chinese Medical Association.
- Place of Presentation
  Taipei Veterans General Hospital
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 上皮間葉転換の腫疫における意義2009
- Author(s)
  佐谷秀行
- Organizer
  第15回日本家族性腫瘍学会学術集会
- Place of Presentation
  秋葉原コンベンションホール
- Year and Date
  2009-06-12
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009
- Author(s)
  佐谷秀行
- Organizer
  第71回大腸癌研究会
- Place of Presentation
  大宮ソニックシティ
- Year and Date
  2009-07-03
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 誘導性腫瘍形成モデルを用いたがん幹細胞の解析2009
- Author(s)
  佐谷秀行
- Organizer
  第11回泌尿器疾患ゲノム解析研究会
- Place of Presentation
  大阪リーガロイヤルホテル。大阪(招待講演)
- Year and Date
  2009-03-14
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 癌幹細胞誘導研究によって得られた細胞癌化機構の新たな知見2009
- Author(s)
  佐谷秀行
- Organizer
  再生医療の実現化プロジェクト、第2回夏のワークショップ
- Place of Presentation
  熱海KKRホテル
- Year and Date
  2009-07-16
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] マウスモデルを用いた癌幹細胞の性状解析と応用。シンポジウム3がん幹細胞2009
- Author(s)
  佐谷秀行
- Organizer
  第8回日本再生医療学会総会
- Place of Presentation
  東京国際フォーラム。東京
- Year and Date
  2009-03-05
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] がん浸潤転移を標的とした治療の開発戦略2009
- Author(s)
  佐谷秀行
- Organizer
  平成21年度政策創薬総合研究推進事業第35回ヒューマンサイエンス総合研究セミナー「次世代の抗がん剤創薬に向けて」
- Place of Presentation
  全国社会福祉協議会・灘尾ホール
- Year and Date
  2009-11-10
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Role of Hyaluronan-CD44 Interaction in Epithelial-Mesenchymal Transition and Cancer Invasion.2009
- Author(s)
  Saya H.
- Organizer
  Global Center of Excellence (GCOE)Program 1^<st> International Symposium
- Place of Presentation
  名古屋
- Year and Date
  2009-01-23
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 遺伝子改変メダカを用いた発癌モデルの構築2009
- Author(s)
  松崎ゆり子, 佐谷秀行
- Organizer
  日本癌学会学術総会
- Place of Presentation
  神奈川県:横浜国際会議場
- Year and Date
  2009-10-01
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] 癌幹細胞理論に基づく腫瘍治療戦略のパラダイムシフト2009
- Author(s)
  佐谷秀行
- Organizer
  第10回日本分子脳神経外科学会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2009-09-20
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Mouse cancer models using induced cancer stem cells.2009
- Author(s)
  Hideyuki Saya
- Organizer
  A Victor A. Levin Lectureship.
- Place of Presentation
  The University of Texas, M.D. Anderson Cancer Center
- Year and Date
  2009-11-18
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 癌幹細胞理論に基づく治療戦略の変革2009
- Author(s)
  佐谷秀行
- Organizer
  第7回日本乳癌学会近畿地方会
- Place of Presentation
  神戸国際会議場
- Year and Date
  2009-12-05
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 癌幹細胞モデルの作製と応用。ランチョンセミナー2009
- Author(s)
  佐谷秀行
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋国際会議場。名古屋
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] マウス腫瘍形成モデルを用いたがん幹細胞の解析2009
- Author(s)
  佐谷秀行
- Organizer
  癌治療開発&先端医療開発を目指した最前線セミナー
- Place of Presentation
  秋葉原UDX Gallery
- Year and Date
  2009-05-18
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Analysis of Myc-induced cancer stem cell models2009
- Author(s)
  Saya H
- Organizer
  USA-Japan Cooperative Cancer Workshop 'Stem Cells in Normal and Malignant Hematopoiesis'
- Place of Presentation
  Hilton Waikoloa Village in Hawaii Big Island.Hawaii
- Year and Date
  2009-03-28
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009
- Author(s)
  佐谷秀行
- Organizer
  第10回検査血液学会学術集会
- Place of Presentation
  山梨大学甲府キャンパス
- Year and Date
  2009-07-04
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] マウス正常細胞より誘導した癌幹細胞様細胞を用いた治療抵抗性機構の解析2009
- Author(s)
  佐谷秀行
- Organizer
  第68回日本癌学会学術総会
- Place of Presentation
  パシフイコ横浜
- Year and Date
  2009-10-03
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009
- Author(s)
  佐谷秀行
- Organizer
  第31回本郷呼吸器研究会
- Place of Presentation
  山の上ホテル
- Year and Date
  2009-06-23
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] メダカを用いた悪性黒色腫モデル系の構築2009
- Author(s)
  松崎ゆり子, 佐谷秀行
- Organizer
  第15回小型魚類研究会
- Place of Presentation
  愛知県名古屋大学野依記念学術交流館
- Year and Date
  2009-09-12
- Data Source
  KAKENHI-PROJECT-21591444
[Presentation] 動物モデルを用いたがん幹細胞の解析と応用2009
- Author(s)
  佐谷秀行
- Organizer
  北海道癌談話会春期シンポジウム
- Place of Presentation
  小樽商科大学札幌サテライト
- Year and Date
  2009-06-27
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 動物モデルを用いたがん幹細胞の特性解析と治療戦略の考案2009
- Author(s)
  佐谷秀行
- Organizer
  第61回日本皮膚科学会西部支部学術大会
- Place of Presentation
  B-CON PLAZA別府国際コンベンションセンター
- Year and Date
  2009-10-24
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 癌の浸潤転移に関わる分子イベント2009
- Author(s)
  佐谷秀行、永野修
- Organizer
  第98回日本病理学会総会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2009-05-01
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Role of Hyaluronan-CD44 Interaction in Epithelial-Mesenchymal Transition and Cancer Invasion2009
- Author(s)
  Saya H
- Organizer
  Invited Speaker. Global Center of Excellence (COE) Program 1^<st> International Symposium
- Place of Presentation
  Nagoya University School of Medicine.Nagoya
- Year and Date
  2009-01-23
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 抗がん剤による細胞死の分子機構2008
- Author(s)
  佐谷秀行
- Organizer
  第5回婦人科がん会議
- Place of Presentation
  宇都宮
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 癌の浸潤転移能を決定づける細胞-マトリクス相互作用2008
- Author(s)
  佐谷秀行
- Organizer
  第41回日本整形外科学会・骨・軟部腫瘍学術学会
- Place of Presentation
  浜松(教育講演)
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 胎盤からみた細胞周期制御因子APC/cdh1の機能2008
- Author(s)
  佐谷秀行
- Organizer
  第31回日本分子生物学会年会第81回日本生化学会大会合同大会。シンポジウム。
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] Molecular mechanism of cell death induced by anti-cancer drugs2008
- Author(s)
  Saya H
- Organizer
  The 15^<th> Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  東京
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Establishment of osteosarcoma cancer stem cells from mouse bone marrow stromal cells2008
- Author(s)
  Saya H
- Organizer
  Invited Speaker. Cancer Genes and Cancer Stem Cells. The 5^<th> Nikko International Symposium 2008
- Place of Presentation
  Jichi Medical University (JMU) Information and In-service Training Center, Japan
- Year and Date
  2008-10-25
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] Molecular mechanism of cell death induced by anti-cancer drugs. Invited speaker.2008
- Author(s)
  Saya H
- Organizer
  The 15th Takeda Science Foundation Symposium on Bioscience
- Place of Presentation
  Sheraton Miyako Hotel Tokyo, Tokyo
- Year and Date
  2008-12-02
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 癌の浸潤・転移抑制創薬への新しいアプローチ2008
- Author(s)
  佐谷秀行
- Organizer
  第12回がん分子標的治療研究会総会
- Place of Presentation
  東京
- Year and Date
  2008-06-26
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 癌幹細胞に基づく癌発生及び維持機構の解析2008
- Author(s)
  佐谷秀行
- Organizer
  第47回日本臨床細胞学会秋期大会
- Place of Presentation
  東京(要望講演)
- Year and Date
  2008-11-14
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 癌の浸潤転移能を決定づける細胞-マトリクス相互作用2008
- Author(s)
  佐谷秀行
- Organizer
  第41回日本整形外科学会・骨・軟部腫瘍学術学会
- Place of Presentation
  浜松
- Year and Date
  2008-07-18
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 抗がん剤による細胞死の分子機構。シンポジウム4「細胞死と血液疾患」2007
- Author(s)
  佐谷秀行
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] Molecular mechanism of anti-cancer therapies. Luncheon Seminar2007
- Author(s)
  Saya H
- Organizer
  Organization for Oncology and Translational Research 4^<th> Annual Conference
- Place of Presentation
  Kyoto, Japan
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 癌幹細胞について解決すべき諸問題。シンポジウム2007
- Author(s)
  佐谷秀行
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 細胞-マトリクス間相互作用と癌細胞浸潤。ランチョンセミナー2007
- Author(s)
  佐谷秀行
- Organizer
  第25回日本ヒト細胞学会学術集会
- Place of Presentation
  都市センターホテル、東京
- Year and Date
  2007-08-04
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 抗がん剤治療の分子メカニズム。Meet the Expert Seminar2007
- Author(s)
  佐谷秀行
- Organizer
  第66回日本癌学会総会
- Place of Presentation
  パシフィコ横浜。横浜
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] 抗がん剤による細胞死の分子機構2007
- Author(s)
  佐谷秀行
- Organizer
  第69回日本血液学会総会シンポジウム4「細胞死と血液疾患
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-13
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] 癌幹細胞について解決すべき諸問題2007
- Author(s)
  佐谷秀行
- Organizer
  第30回日本分子生物学会年会、第80回日本生化学会大会シンポジウム3S28「癌幹細胞一組織幹細胞と何が似て、何が違うか」
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] Auroraキナーゼの発がんにおける役割,合同シンポジウム5「シグナル伝達研究と分子標的療法」2007
- Author(s)
  佐谷秀行
- Organizer
  第69回日本血液学会総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19209048
[Presentation] Molecular mechanism of anti-cancer therapies. Special Lecture.2007
- Author(s)
  Saya H
- Organizer
  International Symposium on 50th Anniversary of Yonsei University
- Place of Presentation
  Yonsei University College of Medicine, Seoul, Korea
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Dynamic analysis of mitotic catastrophe.2005
- Author(s)
  Saya H
- Organizer
  International Symposium on "DNA replication and cell cycle"
- Place of Presentation
  Tokyo University, Tokyo, Japan
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Role of Aurora kinases in mitotic regulation and tumorigenesis.2005
- Author(s)
  Saya H
- Organizer
  Plenary Lecture. Annual meeting of the Korean Society of Medical Biochemistry and Molecular Biology
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] Molecular understanding and dynamic analysis of anti-cancer therapy. Special Lecture (Prof. Takao Hoshino's Memorial Lecture).2005
- Author(s)
  Saya H
- Organizer
  4th Meeting of the Asian Society of Neuro-Oncology
- Place of Presentation
  Taipei, Taiwan
- Data Source
  KAKENHI-PROJECT-17013070
[Presentation] グリオーマの基礎生物学
- Author(s)
  佐谷秀行
- Organizer
  第33回日本脳神経外科コングレス総会
- Place of Presentation
  大阪国際会議場
- Invited
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] Regulation of cell differentiation by actin dynamics and its application in cancer treatment.
- Author(s)
  Hideyuki Saya
- Organizer
  Aichi Cancer Center 50th Anniversary International Symposium.
- Place of Presentation
  Aichi Cancer Center, Nagoya
- Year and Date
  2015-03-13 – 2015-03-14
- Data Source
  KAKENHI-PLANNED-22130007
[Presentation] Novel therapeutic strategies for cancer stem cells
- Author(s)
  Saya Hideyuki
- Organizer
  The 39th Annual Meeting of Korean Cancer Association
- Place of Presentation
  Seoul, Korea
- Invited
- Data Source
  KAKENHI-PROJECT-25253085
[Presentation] Expression of CD44 Variant 9 Contributes to 5-Fluorouracil Resistance in Gastric Cancer Trough Anti-Oxidative Stress Mechanism.
- Author(s)
  Okada, S., Suzuki, H., Masaoka, T., Tsugawa, H., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Saya, H., Hibi, T.
- Organizer
  Digestive Disease Week 2013
- Place of Presentation
  Orlando
- Data Source
  KAKENHI-PROJECT-25293178
[Presentation] Autophagy causing CagA degradation is triggered by cytoplasmic accumulation of low-density lipoprotein receptor-related protein-1 (LRP1) in gastric epithelial cells infected with H. pylori.
- Author(s)
  Tsugawa, H., Matsuzaki, J., Okada, S., Fukuhara, S., Mori, H., Masaoka, T., Sato, A., Saya, H., Hatakayama, M., Hirayama, T., Suzuki, H.
- Organizer
  UEGW2013
- Place of Presentation
  Berlin
- Data Source
  KAKENHI-PROJECT-25293178
[Presentation] xCT標的治療はCD44v陽性口腔扁平上皮癌細胞を選択的に死滅させる
- Author(s)
  吉川桃子, 莇生田整治, 河奈裕正, 中川種昭, 佐谷秀行
- Organizer
  第58回（社）日本口腔外科学会総会, 福岡, 2013.10.
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-25462930
[Presentation] CD44v9 play a role to anti-tumor effect against human gastric cancer by trastuzumab.
- Author(s)
  Mori, H., Suzuki, H., Matsuzaki, J., Tsugawa, H., Fukuhara, S., Miyoshi, S., Masaoka, T., Kanai, T., Saya, H.
- Organizer
  The 4th JCA-AACR Special Joint Conference
- Place of Presentation
  Urayasu
- Data Source
  KAKENHI-PROJECT-25293178
[Presentation] xCT inhibition depletes CD44v-expressing squamous cell carcinoma cells that are resistant to EGFR-targeted therapy
- Author(s)
  Momoko Yoshikawa, Osamu Nagano, Kenji Tsuchihashi, Seiji Asoda, Hiromasa Kawana, Taneaki Nakagawa, Hideyuki Saya
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25462930
[Presentation] Establishment of the medaka melanoma model and drug administration trials
- Author(s)
  Hosokai H, Shimizu A, Saya H, Fukamachi S, Mizuguchi Y, Matsuzaki Y
- Organizer
  第18回小型魚類研究会
- Place of Presentation
  京都大学（京都）
- Data Source
  KAKENHI-PROJECT-24591633
[Presentation] Novel Therapeutic Strategies for Cancer Stem Cells.
- Author(s)
  Hideyuki Saya
- Organizer
  Weatherall Institute of Molecular Medicine (WIMM) Seminar
- Place of Presentation
  University of Oxford, UK
- Invited
- Data Source
  KAKENHI-ORGANIZER-22130001
[Presentation] H. pyloriがん蛋白質CagAのCD44v9発現がん幹細胞特異的蓄積メカニズムの発見
- Author(s)
  津川仁、鈴木秀和、佐谷秀行、松崎潤太郎、平田賢郎、福原誠一郎、岡田佐和子、正岡建洋、畠山昌則、平山壽哉、日比紀文
- Organizer
  第19回日本ヘリコバクター学会学術集会
- Place of Presentation
  長崎
- Data Source
  KAKENHI-PROJECT-25293178
[Presentation] 抗癌剤スクリーニングに用いるための遺伝子導入メダカ腫瘍モデルの確立
- Author(s)
  松崎ゆり子・佐谷秀行
- Organizer
  日本動物学会
- Place of Presentation
  岡山県岡山市
- Data Source
  KAKENHI-PROJECT-24591633
[Presentation] Expression of CD44 variant 9 contributes to 5-fluorouracil resistance in gastric cancer through anti-oxidative stress mechanism
- Author(s)
  Miyoshi, S., Suzuki, H., Tsugawa, H., Masaoka, T., Matsuzaki, J., Fukuhara, S., Hirata, K., Mori, H., Kanani, T., Saya, H.
- Organizer
  17th Biennial Meeting of Society for Free Radical Research International (SFRRI2014)
- Place of Presentation
  Kyoto
- Data Source
  KAKENHI-PROJECT-25293178
[Presentation] Roles of CD44 in cancer stem cells.
- Author(s)
  Hideyuki Saya
- Organizer
  The American Association for Cancer Research (AACR) Annual Meeting 2013
- Place of Presentation
  Washington, DC, USA
- Invited
- Data Source
  KAKENHI-ORGANIZER-22130001
[Presentation] Establishment of transgenic medaka as a stable tumor model for in vivo screening of anticancer drugs
- Author(s)
  松崎ゆり子・細貝春・水口幸代・清水厚志・佐谷秀行
- Organizer
  アメリカ癌学会
- Place of Presentation
  米国・ワシントンDC
- Data Source
  KAKENHI-PROJECT-24591633

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157. 中村亮一

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158. 岡野栄之

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159. 鈴木ゆり子

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160. 有馬好美

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161. 三輪正直

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162. 菅野雅元

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163. 佐藤結子

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164. 清水律子

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165. 山本雄広

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166. 永野修

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167. 岡崎章悟

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168. 金井昭教

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169. 滝田順子

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170. 佐田政隆

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171. 本田善一郎

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172. 本田浩章

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173. 加部泰明

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174. 犬飼岳史

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175. 森肇

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176. 三上修治

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177. 水野隆一

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178. 大家基嗣

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179. 小坂威雄

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180. 川尻秀一

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181. 中川種昭

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182. 喜納宏昭

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183. 青木伊知男

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184. 西山伸宏

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185. CABRAL Horacio

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186. 持田祐希

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187. 森岡秀夫

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188. 温川恭至

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189. 石本崇胤

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190. 太田昭一郎

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191. 出原賢治

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192. 福田桂太郎

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193. 戸田口淳也

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194. 岡正朗

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195. 恒富亮一

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196. 園田康平

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197. 岡部弘尚

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198. 渡邊雅之

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199. 岩槻政晃

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201. 馬場秀夫

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207. 小島研介

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208. 小池直義

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209. 公田龍一

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211. 伊東史子

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212. 松崎文雄

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213. 古屋充子

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215. 久保田義顕

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217. 甲村英二

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218. 篠山隆司

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219. 近藤豊

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220. 生田宏一

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Saya Hideyuki 佐谷 秀行

SAYA Hideyuki 佐谷 秀行

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メチオニン代謝を基盤としたがん治療抵抗性機構の解明と新規治療標的の同定Principal Investigator

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がん関連線維芽細胞誘導分子機構の解明とその阻害に基づく腫瘍微小環境制御Principal Investigator

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Development of new therapeutic agents for pancreatic cancer targeting 14-3-3dzetaPrincipal Investigator

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Elucidation of underlyingmechanism of MKL1-mediated induction of cancer associated fibroblasts and its clinical applicationsPrincipal Investigator

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Analysis of escaping mechanism from immune system by microenvironment of cancer stem cellsPrincipal Investigator

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Development of a novel anti-invasion therapy targeting the glioma stem cell/endothelial cell invasion complexPrincipal Investigator

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Saya Hideyuki 佐谷秀行

SAYA Hideyuki 佐谷秀行