Chiba Shigeru 千葉滋

… Alternative Names

Researcher Number	60212049
Other IDs
Affiliation (Current)	2019: 筑波大学, 医学医療系, 教授
Affiliation (based on the past Project Information) *help	2011 – 2019: 筑波大学, 医学医療系, 教授 2010 – 2011: 筑波大学, 人間総合科学研究科, 教授 2007 – 2010: University of Tsukuba, 大学院・人間総合科学研究科, 教授 2007: The University of Tokyo, 医学部附属病院, 准教授 2003 – 2006: The University of Tokyo, Faculty of Medicine, Associate Professor, 医学部附属病院, 助教授 … More
Review Section/Research Field	Principal Investigator Hematology / Biological Sciences / Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Hematology / Hematology / Biological Sciences / Complex systems / Laboratory medicine / Molecular biology / Cell biology / Experimental pathology / Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator Notch / 癌 / 白血病 / 遺伝子 / シグナル伝達 / がん / 細胞・組織 / 分化抑制 / GATA2 / 造血器腫瘍 … More Except Principal Investigator 白血病 / 転写因子 / 造血幹細胞 / JNK / MEN / ノックアウトマウス / MLL / Notch / Evi-1 / アポトーシス / 癌抑制遺伝子 / t(11;19) / GATA-2 / Cas / TGFβ / Smad3 / CIZ / 急性リンパ性白血病 / 非ホジキンリンパ腫 / AML1 / 造血器腫瘍 / 細胞周期 / RNAポリメラーゼII伸長因子 / 転写伸長因子 / p53 / MDS / Leukemia / SH3 / 核内蛋白質 / zinc finger / MAP kinase / ストレス刺激 / 染色体転座 / MLL遺伝子 / MEN遺伝子 / 慢性骨髄性白血病 / 細胞分化 / p16遺伝子 / チロシンリン酸化 / 分化 / Notchシグナル / ES細胞 / 活性化型Notch1 / ゲノム / マイクロアレイ / コピー数解析 / モデルマウス / Affymetrix / 癌幹細胞 / 分子標的治療 / SNPアレイ / 急性骨髄性白血病 / 骨髄異形成症候群 / インテグリン / 細胞接着 / focal adhesion / knockout mouse / Jagged1 / EVI-1 / CtBP / apoptosis / BMP / del(7q) / CNAG / UPD / LOH / Blimp-1 / TET2 / RHOA / T細胞リンパ腫 / 染色体欠失 / 発癌機構 / FISH法 / t(3;21)染色体転座 / EVI-1キメラ遺伝子 / リン酸化 / レドックス制御 / 11q23転座 / 転写伸長活性 / AML1遺伝子 / Evi-1融合蛋白質 / 転写活性 / 造血細胞 / 細胞増殖 / キメラ蛋白質 / 転写制御因子 / 癌抑制 / ALL / リンパ系腫瘍 / p15遺伝子 / Rb遺伝子 / p53遺伝子 / DNAミスマッチ修復 / MLH1遺伝子 / AP‐1活性 / p130^<Cas> / actin線維の束状形成 / c-Crk / c-Src / 血管拡張 / FAK / ノックアウト / ノックイン / 骨髄系前駆細胞 / 赤芽球系細胞 / 幹細胞増幅 / 骨髄支持細胞 / Notchl / 赤芽球系前駆細胞 / 6q21 / FISH / 欠失 / 腫瘍抗原 / メラノーマ / T細胞 / 樹状細胞 / 免疫療法 / 網羅的遺伝子解析 / siRNA / DNAクローニング / DNAチップ / SAGE / SEREX / レンチウイルス / 癌抗原 / 色素細胞 / ペプチド / 造血幹細 / 造血発生 / 1次造血 / 2次造血 / HES-1 / paraaortic splanchnopleures / yalk sac / Notchリガンド / 造血幹細胞増幅 / RAS / MAPKシグナル / 可塑性 / ヒトES細胞 / 血球細胞 / Tie2 / GFP / 再生医療 / 幹細胞 / 再生医学 / paraaortic-splanchnopleura(P-SP)領域 / 血管内皮細胞 / アレイCGH / 染色体 / 欠損 / 増幅 / メチル化 / 癌 / 細胞・組織 / 生体分子 / 幹細胞ニッチ / 白血病幹細胞 / 異種移植 / 免疫不全マウス / マクロファージ寛容 / SIRPA / CD47 / マクロフ / がんゲノム / リシーケンス / 癌の個性 / 分子標的 / 大量並列シーケンス / 腫瘍内多様性 / 成人T細胞白血病 / 血管免疫芽球性T細胞リンパ種 / RHOA変異 / Low grade glioma / エクソンシーケンス / がん / RNAスプライシング / ATL / miR31 / SF3B1 / クロマチン制御 / 腎細胞癌 / DNA二重鎖切断 / 放射線 / H2AX / 脱リン酸化 / 修復 / gammaH2AX / 損傷DNA修復 / DNA二重らせん切断 / 末梢血白血球 / フローサイトメトリー / DNA損傷修復 / Hes1 / 腫瘍抑制 / サイトカイン受容体 / 腫瘍抑制因子 / MLL白血病 / レトロウイルス / ウィルムス腫瘍 / がん抑制遺伝子 / Transcription factor / Tmuor suppressor gene / Wilms' tumor / アクチン線維 / シグナル伝達 / subcellular localization / myofibril / smad3 / 増殖抑制 / 増殖抑制因子 / t(11;19)転座型白血病 / 足場非依存性増殖 / Cell growth / Stress / Apoptosis / Notch蛋白質 / DSLドメイン / Notch1 / Notch2 / Notch3 / EGF様リピート / 自己複製能 / ストローマ細胞 / 遺伝子治療 / CD34 / アデノウイルス / EGF受容体 / LTC-IC / DSL domain / differentiation / active Notch1 / transcription factor / MEM / キメラ型転写因子 / t(3;21) / 細胞骨格 / マトリックス・メタロプロテアーゼ / アクチン / 心筋線維 / マトリックスメタロプロテアーゼ / プロモーター / 転写制御 / SH3 domain / matrix metalloproteinase / actin stress fiber / nucleo-cytoplasmic shuttling protein / 生殖細胞 / spermatogenic cell / t(1;7)(q10;p10) / メチル化解析 / アルフォイド配列 / CpGアイルランド / メチル化パターン / CpGアイランド / der(1;7)(q10;p10) / 欠失解析 / t(1;7)(q10:910) / methylation analysis / myelodysplastic syndrome / alphoid sequences / CpG islands / Methylation pattern / アレル特異的解析 / Blimp1 / Copy number analysis / SNP array / Allele-specific analysis / cell cycle / NOTCHシグナル / 造血支持細胞 / 骨髄微小環境 / Ｔ細胞リンパ腫 / 炎症細胞 / 微小環境 / クローン進化 / 支持環境細胞 / 前がん細胞 Less

胚中心B細胞とリンパ球再循環に注目した濾胞性ヘルパーT細胞リンパ腫病態の解明Principal InvestigatorOngoing
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Tsukuba
Mechanisms of tumor-supporting mechanisms in hematologic malinganciesOngoing
- Principal Investigator
  
  坂田麻実子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Tsukuba
Integrated approach toward angioimmunoblastic T-cell lymphoma - elucidation of molecular mechanism and development of diagnostics and therapeuticsPrincipal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Clonal evolution of tumor-infiltrating cells in T-cell lymphomas
- Principal Investigator
  
  Sakata-Yanagimoto Mamiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
エイジングに伴うエピゲノム変化に注目した造血幹細胞の前がん化機構Principal InvestigatorOngoing
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Unraveling bone marrow erythropoiesis nichePrincipal Investigator
- Principal Investigator
  
  Chiba Shigeru
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Elucidation of the pathological mechanism in refractory leukemia,
- Principal Investigator
  
  KATO Takayasu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
悪性リンパ腫における腫瘍細胞と微小環境とのコミュニケーションPrincipal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Origin of inflammatory cells constituting malignant lymphoma tissuePrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
TET2 gene abnormality and epigenetic dysregulation in hematologic malignanciesPrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
造血細胞運命決定においてＨｅｓ１の可逆的短時間発現変動が果たす役割Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Establishment of evaluation method for double strand repair capacity with peripheral blood
- Principal Investigator
  
  SUZUKAWA Kazumi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory medicine
- Research Institution
  University of Tsukuba
Pathophysiology of myelodyspoastic syndrome - network between bone marrow and nervus systemPrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Analysis of Hes1 mediated development and maintenance of leukemic stem cells for myeloid leukemia
- Principal Investigator
  
  SAKATA Mamiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Development of Novel Treatment Strategies Targeting Cancer Stem Cells
- Principal Investigator
  
  AKASHI Koichi
- Project Period (FY)
  2010 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Identification and in vivo analysis of human cancer stem cells
- Principal Investigator
  
  AKASHI Koichi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
seishi
- Principal Investigator
  
  SEISHI ogawa
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
  The University of Tokyo
巨核球産生ニッチの可視化とニッチにおけるNotchシグナルの機能解析Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
がんにおけるNotchシグナル異常の解析とこれを標的とした抗腫瘍療法開発研究Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Tsukuba
Role of cell environmental signaling in the establishment of hematopoietic malignanciesPrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
Notchシグナル亢進による腫瘍化機構の解明Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ハイドロキシアパタイトマイクロキャリアーを利用した造血幹細胞増幅法と移植法の開発Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Notchシグナル亢進による腫瘍化機構の解明Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Notchシグナル阻害によるマスト細胞制御・新たな自己免疫疾患治療法開発に向けてPrincipal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Hematopoietic stem cell regulation by the Notch signaling-including hematopoietic stem cell induction from human embryonic stem cells-Principal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
DNAアレイを用いた造血細胞分化におけるメチル化プロファイルの網羅的経時的検討
- Principal Investigator
  
  小川誠司
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Exploring leukemogenic mechanism using genomic analysis and mouse genetics.
- Principal Investigator
  
  OGAWA Seishi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Functional analysis of Blimp-1
- Principal Investigator
  
  HANGAISHI Akira
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
ゲノムアレイCGHを用いた造血器腫瘍における染色体欠失・増幅領域の網羅的解析
- Principal Investigator
  
  小川誠司
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
幹細胞可塑性の分子メカニズムと再生医学研究Principal Investigator
- Principal Investigator
  
  千葉滋, 平井久丸
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Assessment of immune modulation by Notch signaling-exploration of immunomodulatory intervention targeting Notch system.Principal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Analysisof CIZ disrupted mice
- Principal Investigator
  
  HANGAISHI Akira
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  The University of Tokyo
GENOM IC ANALYSIS OF (1;7) TRANSLOCATION AND del(7q) IN MYELODYSPLASTIC SYNDROME
- Principal Investigator
  
  OGAWA Seishi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  The UNIVERSITY OF TOKYO
白血病を標的とした新たな免疫細胞治療法の開発研究Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
DEVELOPMENT OF IMMUNOTHERAPY To HEMATOLOGIC MALIGNANCIESPrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru, 平井久丸
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Notchシグナルによる造血の制御Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
メラノーマに対する新しい免疫療法の開発
- Principal Investigator
  
  河上裕
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University
Notchリガンドを利用した造血幹細胞の増幅とその実用化
- Principal Investigator
  
  平井久丸
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
11q23転座型白血病の分子機構の解析
- Principal Investigator
  
  三谷絹子
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
ヒト染色体6q16.3-21に存在する新規癌抑制遺伝子の同定と単離
- Principal Investigator
  
  小川誠司
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Notchシグナルによる造血の抑制Principal Investigator
- Principal Investigator
  
  千葉滋
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Analysis of molecular mechanisms in leukemogenesis by chimeric transcription factors
- Principal Investigator
  
  NAKAMURA Yuichi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hematology
- Research Institution
  Dokkyo University School of Medicine
  The University of Tokyo
Notch in hematopoiesisPrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo Hospital
Analyses of Maltipotential Functions of a Novel Signaling Molecule, Cas
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A).
- Research Field
  
  Cell biology
- Research Institution
  University of Tokyo
ノックアウトマウスを用いた新規情報伝達物質p130^<Cas>の生物学的機能解析
- Principal Investigator
  
  小川誠司
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
発生工学的手法を用いたヒト白血病モデルマウスの作製
- Principal Investigator
  
  三谷絹子
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
造血幹細胞複製因子の同定・単離とその実用化
- Principal Investigator
  
  平井久丸
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
基本転写因子異常による造血幹細胞腫瘍化の機構の解析
- Principal Investigator
  
  三谷絹子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Analyses of a Novel Signaling Molecule, Cas
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  University of Tokyo
Analysis of molecular mechanisms of leukemia development
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Practical development of a novel method for hematopoietic stem cell expansion
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Ex vivo expansion of hematopoietic stem cells using adenovirusPrincipal Investigator
- Principal Investigator
  
  CHIBA Shigeru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tokyo
造血器腫瘍の予後に関する遺伝子診断法の開発
- Principal Investigator
  
  平井久丸
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  The University of Tokyo
Functional analysis of the Wilms' tumor suppressor gene WT1 in hematopoiesis.
- Principal Investigator
  
  MIYAGAWA Kiyoshi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  HIROSHIMA UNIVERSITY
造血器腫瘍の遺伝子診断法の開発と実用化
- Principal Investigator
  
  HIRAI Hisamaru
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo

[Book] プレシジョン・メディシン　ビッグデータの構築・分析から臨床応用・課題まで2018
- Author(s)
  千葉　滋、他54名（分担執筆）
- Total Pages
  373
- Publisher
  エヌ・ティー・エス
- ISBN
  9784860435806
- Data Source
  KAKENHI-PROJECT-16H02660
[Book] 実験医学別冊「がんと代謝」2012
- Author(s)
  坂田 (柳元)麻実子, 千葉滋
- Data Source
  KAKENHI-PROJECT-23791068
[Book] 最新医学別冊2011
- Author(s)
  千葉滋
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-23659482
[Book] 血液2011(Annual Review)2011
- Author(s)
  千葉滋(分担執筆)
- Total Pages
  229
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-22390191
[Book] 血液疾患最新の治療2011-20132010
- Author(s)
  千葉滋(分担執筆)
- Total Pages
  408
- Publisher
  南江堂
- Data Source
  KAKENHI-PROJECT-22390191
[Book] 造血器腫瘍アトラス-形態、免疫、染色体と遺伝子- 改訂第4版, 「Notch遺伝子」2009
- Author(s)
  千葉滋
- Publisher
  日本医事新報社
- Data Source
  KAKENHI-PROJECT-19390258
[Book] Annual Review血液2008, 「Notch遺伝子と造血幹細胞増幅および白血病との関わり」2008
- Author(s)
  千葉滋
- Publisher
  中外医学社
- Data Source
  KAKENHI-PROJECT-19390258
[Book] 三輪血液病学(改訂第3版)(造血幹細胞の検査)2006
- Author(s)
  千葉滋(分担執筆)
- Publisher
  文光堂
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Book] 再生医療のための分子生物学(幹細胞のシグナル伝達~Notch~)2006
- Author(s)
  千葉滋(分担執筆)
- Publisher
  コロナ社
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Book] Molecular Biology for Regenerative Medicine (Signal transduction in stem cells〜 Notch〜)2006
- Author(s)
  Shigeru Chiba (co-author)
- Publisher
  Corona Publishing CO., Ltd.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Book] Miwa's Hematology (3rd edition) (Laboratory examination of hematopoietic stem cells)2006
- Author(s)
  Shigeru Chiba (co-author)
- Publisher
  Bunkodo Co.Ltd.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Book] Bessatsu Igaku-no-Ayumi-Hematological disorders-State of arts Ver.3 (Notch signaling and hematopoietic cells)2005
- Author(s)
  Shigeru Chiba (co-author)
- Publisher
  Ishiyaku Publishers, Inc.
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Book] 別冊・医学のあゆみ-血液疾患-State of arts(Notchシグナルと造血細胞)2005
- Author(s)
  千葉滋(分担執筆)
- Publisher
  医歯薬出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Genetic evidence implies that primary and relapsed tumors arise from common precursor cells in primary central nervous system lymphoma2018
- Author(s)
  Hattori Keiichiro、Sakata-Yanagimoto Mamiko、Kusakabe Manabu、Nanmoku Toru、Suehara Yasuhito、Matsuoka Ryota、Noguchi Masayuki、Yokoyama Yasuhisa、Kato Takayasu、Kurita Naoki、Nishikii Hidekazu、Obara Naoshi、Takano Shingo、Ishikawa Eiichi、Matsumura Akira、Muratani Masafumi、Hasegawa Yuichi、Chiba Shigeru
- Journal Title
  
  Cancer Science
  
  Volume: 110 Pages: 401-407
- DOI
  10.1111/cas.13848
- NAID
  120006583035
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09946, KAKENHI-PROJECT-18K16076, KAKENHI-PROJECT-16H02660
[Journal Article] Activation of RHOA?VAV1 signaling in angioimmunoblastic T-cell lymphoma2018
- Author(s)
  Fujisawa M., Sakata-Yanagimoto M., Nishizawa S., Komori D., Gershon P., Kiryu M., Tanzima S., Fukumoto K., Enami T., Muratani M., Yoshida K., Ogawa S., Matsue K., Nakamura N., Takeuchi K., Izutsu K., Fujimoto K., Teshima T., Miyoshi H., Gaulard P., Ohshima K., Chiba S.
- Journal Title
  
  Leukemia
  
  Volume: 32 Pages: 694-702
- DOI
  10.1038/leu.2017.273
- NAID
  120006460147
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-16K15497
[Journal Article] Progression to polythythemia vera from familial thrombocytosis with germline JAK2 R867Q mutation.2018
- Author(s)
  Maie Koichiro、Yokoyama Yasuhisa、Yano Yoko、Kato Takayasu、Nannya Yasuhito、Ogawa Seishi、Noguchi Masayuki、Sakata-Yanagimoto Mamiko、Chiba Shigeru
- Journal Title
  
  Ann Hematol.
  
  Volume: 97 Pages: 737-739
- DOI
  10.1007/s00277-017-3209-1
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-26221308
[Journal Article] Droplet digital polymerase chain reaction assay and peptide nucleic acid-locked nucleic acid clamp method for RHOA mutation detection in angioimmunoblastic T-cell lymphoma2018
- Author(s)
  Tanzima Nuhat S, Sakata-Yanagimoto M, Komori D, Hattori K, Suehara Y, Fukumoto K, Fujisawa M, Kusakabe M, Matsue K, Wakamatsu H, Shimadzu M, Chiba S
- Journal Title
  
  Cancer Science
  
  Volume: - Pages: 1682-1689
- DOI
  10.1111/cas.13557
- NAID
  120006492175
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-18K16076
[Journal Article] Clinical significance of disease-specific MYD88 mutations in circulating DNA in primary central nervous system lymphoma2018
- Author(s)
  Hattori Keiichiro、Sakata-Yanagimoto Mamiko、Suehara Yasuhito、Yokoyama Yasuhisa、Kato Takayasu、Kurita Naoki、Nishikii Hidekazu、Obara Naoshi、Takano Shingo、Ishikawa Eiichi、Matsumura Akira、Hasegawa Yuichi、Chiba Shigeru
- Journal Title
  
  Cancer Science
  
  Volume: 109 Pages: 225-230
- DOI
  10.1111/cas.13450
- NAID
  120006410916
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-15H04947, KAKENHI-PROJECT-16K15497
[Journal Article] Liquid biopsy for the identification of intravascular large B-cell lymphoma2018
- Author(s)
  Suehara Yasuhito、Sakata-Yanagimoto Mamiko、et al
- Journal Title
  
  Haematologica
  
  Volume: in press
- DOI
  10.3324/haematol.2017.178830
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-17K09946, KAKENHI-PROJECT-18K07436, KAKENHI-PROJECT-18K16076, KAKENHI-PROJECT-18K16107, KAKENHI-PROJECT-16H02660
[Journal Article] A phase I/II trial of intrabone marrow cord blood transplantation and comparison of the hematological recovery with the Japanese nationwide database.2017
- Author(s)
  Kurita N, Gosho M, Yokoyama Y, Kato T, Obara N, Sakata-Yanagimoto M, Hasegawa Y, Uchida N, Takahashi S, Kouzai Y, Atsuta Y, Kurata M, Ichinohe T, Chiba S
- Journal Title
  
  Bone marrow transplantation
  
  Volume: 52 Pages: 574-579
- DOI
  10.1038/bmt.2016.319
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19542, KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-15K19543
[Journal Article] Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis.2017
- Author(s)
  Pierini A*, Nishikii H*, Baker J, Kimura T, Kwon H-S, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS. (*equal contribution)
- Journal Title
  
  Nature Communication
  
  Volume: 8 Pages: 15068-15068
- NAID
  120006306174
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15359
[Journal Article] Review of the biologic and clinical significance of genetic mutations in angioimmunoblastic T-cell lymphoma2017
- Author(s)
  Fukumoto K、Nguyen TB、Chiba S、Sakata-Yanagimoto M
- Journal Title
  
  Cancer Science
  
  Volume: 109 Pages: 490-496
- DOI
  10.1111/cas.13393
- NAID
  120006460173
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-16K15497
[Journal Article] Dynamics of clonal evolution in myelodysplastic syndromes2017
- Author(s)
  Makishima H, et al.
- Journal Title
  
  Nature genetics
  
  Volume: 49 Pages: 204-204
- DOI
  10.1038/ng.3742
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PLANNED-15H05912, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16H05338, KAKENHI-PROJECT-15H05668, KAKENHI-PROJECT-15H05707, KAKENHI-PROJECT-16H02660
[Journal Article] Dysregulation of TET2 in hematologic malignancies.2017
- Author(s)
  Chiba S.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 105 Pages: 17-21
- DOI
  10.1007/s12185-016-2122-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02660
[Journal Article] BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma2017
- Author(s)
  Nishizawa S, Sakata-Yanagimoto M, Hattori K, Muto H, Nguyen T, Izutsu K, Yoshida K, Ogawa S, Nakamura N, Chiba S.
- Journal Title
  
  International journal of hematology
  
  Volume: - Pages: 465-469
- DOI
  10.1007/s12185-016-2159-z
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-16H02660
[Journal Article] Detection of the circulating tumor DNAs in angioimmunoblastic T- cell lymphoma2017
- Author(s)
  Sakata-Yanagimoto Mamiko、Nakamoto-Matsubara Rie、Komori Daisuke、Nguyen Tran B.、Hattori Keiichiro、Nanmoku Toru、Kato Takayasu、Kurita Naoki、Yokoyama Yasuhisa、Obara Naoshi、Hasegawa Yuichi、Shinagawa Atsushi、Chiba Shigeru
- Journal Title
  
  Annals of Hematology
  
  Volume: 96 Pages: 1471-1475
- DOI
  10.1007/s00277-017-3038-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-16K15497
[Journal Article] Recent Progress in the Understanding of Angioimmunoblastic T-cell Lymphoma2017
- Author(s)
  Fujisawa M, Chiba S, Sakata-Yanagimoto M
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 57 Issue: 3 Pages: 109-119
- DOI
  10.3960/jslrt.17019
- NAID
  130006286291
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-16K15497
[Journal Article] MYD88 (L265P) mutation is associated with an unfavourable outcome of primary central nervous system lymphoma2017
- Author(s)
  Hattori K, Sakata-Yanagimoto M, Okoshi Y, Goshima Y, Yanagimoto S, Nakamoto-Matsubara R, Sato T, Noguchi M, Takano S, Ishikawa E, Yamamoto T, Matsumura A, Chiba S.
- Journal Title
  
  British Journal of Haematology
  
  Volume: - Pages: 492-494
- DOI
  10.1111/bjh.14080
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-16H02660
[Journal Article] A single institutional retrospective evaluation for younger patients with primary central nervous lymphomas on a modified R-MPV regimen followed by radiotherapy and high dose cytarabine2017
- Author(s)
  Hattori Keiichiro、Sakata-Yanagimoto Mamiko、Okoshi Yasushi、Kato Takayasu、Kurita Naoki、Yokoyama Yasuhisa、Obara Naoshi、Takano Shingo、Ishikawa Eiichi、Yamamoto Tetsuya、Matsumura Akira、Hasegawa Yuichi、Chiba Shigeru
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 57 Issue: 2 Pages: 41-46
- DOI
  10.3960/jslrt.17012
- NAID
  130006854539
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-16K15497
[Journal Article] Identification of cell-type-specific mutations in nodal T-cell lymphomas2017
- Author(s)
  Nguyen TB, Sakata-Yanagimoto M, Asabe Y, Matsubara D, Kano J, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Izutsu K, Nakamura N, Takeuchi K, Miyoshi H, Ohshima K, Minowa T, Ogawa S, Noguchi M, Chiba S.
- Journal Title
  
  Blood cancer journal
  
  Volume: 7
- DOI
  10.1038/bcj.2016.122
- NAID
  120006023408
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-16H02660, KAKENHI-PLANNED-15H05909
[Journal Article] Clinicopathologic Analysis of Angioimmunoblastic T-cell Lymphoma With or Without RHOA G17V Mutation Using Formalin-fixed Paraffin-embedded Sections.2016
- Author(s)
  Nagao R, Kikuti YY, Carreras J, Kikuchi T, Miyaoka M, Matsushita H, Kojima M, Ando K, Sakata-Yanagimoto M, Chiba S, Nakamura N.
- Journal Title
  
  American Journal of Surgical Pathology
  
  Volume: 40 Pages: 1041-1050
- DOI
  10.1097/pas.0000000000000651
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08976, KAKENHI-PROJECT-16K15497, KAKENHI-PROJECT-16H02660
[Journal Article] Notch遺伝子2016
- Author(s)
  加藤貴康，千葉滋.
- Journal Title
  
  造血器腫瘍アトラス
  
  Volume: － Pages: 45-51
- Data Source
  KAKENHI-PROJECT-15K19543
[Journal Article] DR3 signaling modulates the function of Foxp3+ regulatory T cells and the severity of acute graft-versus-host disease.2016
- Author(s)
  Nishikii H, Kim BS, Yokoyama Y, Chen Y, Baker J, Pierini A, Alvarez M, Mavers M, Maas-Bauer K, Pan Y, Chiba S, Negrin RS.
- Journal Title
  
  Blood
  
  Volume: 128 Pages: 2846-2858
- DOI
  10.1182/blood-2016-06-723783
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660, KAKENHI-PROJECT-15K15359
[Journal Article] A nationwide survey of co-occurrence of malignant lymphomas and myelodysplastic syndromes/myeloproliferative neoplasms.2016
- Author(s)
  Sakata-Yanagimoto M, Yokoyama Y, Muto H, Obara N, Kurita N, Kato T, Hasegawa Y, Miyazaki Y, Kurokawa M, Chiba S
- Journal Title
  
  Annals of Hematology.
  
  Volume: 98 Pages: 829-30
- DOI
  10.1007/s00277-016-2612-3
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461408, KAKENHI-PROJECT-25461407, KAKENHI-PROJECT-15K19543
[Journal Article] TET2 as a gatekeeper for hematologic malignancies2015
- Author(s)
  武藤秀治, 坂田（柳元）麻実子, 千葉滋
- Journal Title
  
  Jpn. J. Clin. Hematol.
  
  Volume: 56 Issue: 6 Pages: 651-656
- DOI
  10.11406/rinketsu.56.651
- NAID
  130005093097
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01504, KAKENHI-PROJECT-26860717
[Journal Article] Molecular Pathogenesis of Peripheral T Cell Lymphoma.2015
- Author(s)
  Sakata-Yanagimoto M, Chiba S.
- Journal Title
  
  Curr Hematol Malig Rep
  
  Volume: 10 Pages: 429-437
- DOI
  10.1007/s11899-015-0289-7
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01504
[Journal Article] Somatic mutations and clonal hematopoiesis in aplastic anemia.2015
- Author(s)
  Yoshizato T, Dumitriu B, Hosokawa K, Makishima H, Yoshida K, Townsley D, Sato-Otsubo A, Sato Y, Liu D, Hiromichi Suzuki H, Wu CO, Shiraishi Y, Clemente MJ, Kataoka K, Shiozawa Y, Okuno Y, Chiba K, Tanaka H, Nagata Y, Katagiri T, Kon A, Sanada M, Scheinberg P, Miyano S, Maciejewski JP, Nakao S, Young NS, Ogawa S.
- Journal Title
  
  NEJM.
  
  Volume: 印刷中
- NAID
  120005623244
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134006
[Journal Article] G17V RHOA: Genetic evidence of GTP-unbound RHOA playing a role in tumorigenesis in T cells.2015
- Author(s)
  Chiba S, Enami T, Ogawa S, Sakata-Yanagimoto M.
- Journal Title
  
  Small GTPases
  
  Volume: 6 Pages: 100-103
- DOI
  10.4161/21541248.2014.988088
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-15H01504, KAKENHI-PROJECT-25461407
[Journal Article] Age-Dependent Decrease of DNA Hydroxymethylation in Human T Cells2015
- Author(s)
  Truong TP, Sakata-Yanagimoto M, Yamada M, Nagae G, Enami T, Nakamoto-Matsubara R, Aburatani H, Chiba S.
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 55(1) Issue: 1 Pages: 1-6
- DOI
  10.3960/jslrt.55.1
- NAID
  130005083797
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08987, KAKENHI-PUBLICLY-15H01504, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-25860521, KAKENHI-PROJECT-25461407
[Journal Article] Double somatic mosaic mutations in TET2 and DNMT3A--origin of peripheral T cell lymphoma in a case.2015
- Author(s)
  Nguyen TB, Sakata-Yanagimoto M, Nakamoto-Matsubara R, Enami T, Ito Y, Kobayashi T, Obara N, Hasegawa Y, Chiba S
- Journal Title
  
  Ann Hematol
  
  Volume: EPUB ahead of print Pages: 1221-1223
- DOI
  10.1007/s00277-015-2332-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25670444, KAKENHI-PROJECT-15K15359, KAKENHI-PROJECT-25461408
[Journal Article] Hes1 suppresses acute myeloid leukemia development through FLT3 repression.2015
- Author(s)
  Kato T, Sakata-Yanagimoto M, Nishikii H, Miyake Y, Yokayama Y, Asabe Y, Kamada Y, Ueno M, Obara N, Suzukawa K, Hasegawa Y, Kitabayashi I, Uchida K, Hirao A, Yagita H, Kageyama R, Chiba S
- Journal Title
  
  Leukemia
  
  Volume: 29 Pages: 576-585
- DOI
  10.1038/leu.2014.281
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25860778, KAKENHI-PROJECT-26290059
[Journal Article] Detection of the G17V RHOA mutation in angioimmunoblastic T-cell lymphoma and related lymphomas using quantitative allele-specific PCR.2014
- Author(s)
  Nakamoto-Matsubara R, Sakata-Yanagimoto M, Enami T, Yoshida K, Yanagimoto S, Shiozawa Y, Nanmoku T, Satomi K, Muto H, Obara N, Kato T, Kurita N, Yokoyama Y, Izutsu K, Ota Y, Sanada M, Shimizu S, Komeno T, Sato Y, Ito T, Kitabayashi I, Takeuchi K, Nakamura N, Ogawa S, Chiba S.
- Journal Title
  
  PLoS One.
  
  Volume: 9
- DOI
  10.1371/journal.pone.0109714
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25461407
[Journal Article] Disease-Specific Mutations in Mature Lymphoid Neoplasms-Recent Advances.2014
- Author(s)
  Sakata-Yanagimoto M, Enami T, Yokoyama Y, Chiba S
- Journal Title
  
  Cancer Science
  
  Volume: 105 Pages: 623-629
- DOI
  10.1111/cas.12408
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25461407
[Journal Article] Somatic RHOA mutation in angioimmunoblastic T cell lymphoma2014
- Author(s)
  Sakata-Yanagimoto M, Yoshida K
- Journal Title
  
  Nat Genet
  
  Volume: 46 Pages: 171-175
- DOI
  10.1038/ng.2872
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04216, KAKENHI-PROJECT-24390241, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659458, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25461407, KAKENHI-PROJECT-25670444, KAKENHI-PROJECT-25670446
[Journal Article] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes.2014
- Author(s)
  Haferlach T, Nagata Y, Grossmann V, Okuno Y, Bacher U, Nagae G, Schnittger S, Sanada M, Kon A, Alpermann T, Yoshida K, Roller A, Nadarajah N, Shiraishi Y, Shiozawa Y, Chiba K, Tanaka H, Koeffler HP, Klein HU, Dugas M, Aburatani H, Kohlmann A, Miyano S, Haferlach C, Kern W, Ogawa S.
- Journal Title
  
  Leukemia
  
  Volume: 28(2) Pages: 4241-247
- DOI
  10.1038/leu.2013.336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04875, KAKENHI-PLANNED-22134006, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24659458, KAKENHI-PROJECT-25670446, KAKENHI-PROJECT-25860521
[Journal Article] Reduced TET2 Function Leads to T-cell Lymphoma with Follicular Helper T cell-like Features in mice.2014
- Author(s)
  Muto H, Sakata-Yanagimoto M, Nagae G, Shiozawa Y, Miyake Y, Yoshida K, Enami T, Kamada Y, Kato T, Uchida K, Nanmoku T, Obara N, Suzukawa K, Sanada M, Nakamura N, Aburatani H, Ogawa S, Chiba S
- Journal Title
  
  Blood Cancer Journal
  
  Volume: 12
- DOI
  10.1038/bcj.2014.83
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-25112703, KAKENHI-PROJECT-25461407, KAKENHI-PLANNED-26115009, KAKENHI-PROJECT-26860717
[Journal Article] S.Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocyticleukemia2013
- Author(s)
  Sakaguchi H, Yoshida K
- Journal Title
  
  Nature genetics
  
  Volume: 46 Pages: 3937-41
- DOI
  10.1038/ng.2698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J04216, KAKENHI-PLANNED-22134006, KAKENHI-PROJECT-23249052, KAKENHI-PROJECT-23591536, KAKENHI-PROJECT-24390242, KAKENHI-PROJECT-24390262, KAKENHI-PROJECT-24659458, KAKENHI-PROJECT-24791054, KAKENHI-PROJECT-25670446
[Journal Article] エピゲノム異常による造血器腫瘍の病態2012
- Author(s)
  坂田 (柳元)麻実子, 千葉滋
- Journal Title
  
  最新医学
  
  Volume: 67(10) Pages: 2413-2419
- Data Source
  KAKENHI-PROJECT-23791068
[Journal Article] 造血器腫瘍とNotchシグナル: 腫瘍活性化2ndHes1+/+ MLLAF9 N=72ndHes1-/- MLLAF9 N=7Hes1+/+ Hes-/-サイトカイン受容体の発現および腫瘍抑制の二面的な役割2012
- Author(s)
  加藤貴康, 坂田(柳元)麻実子, 千葉滋
- Journal Title
  
  血液内科
  
  Volume: 64(6) Pages: 756-760
- Data Source
  KAKENHI-PROJECT-23791068
[Journal Article] Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin2012
- Author(s)
  Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
- Journal Title
  
  Oncogene. 9
  
  Volume: 31 Pages: 787-79
- DOI
  10.1038/onc.2011.265
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19679001, KAKENHI-PROJECT-20221010, KAKENHI-PUBLICLY-22121513, KAKENHI-PROJECT-22247010, KAKENHI-PROJECT-23791068, KAKENHI-ORGANIZER-24111001
[Journal Article] Notchシグナルを標的にした新たな分子標的治療薬の開発2012
- Author(s)
  坂田 (柳元)麻実子, 千葉滋
- Journal Title
  
  血液内科
  
  Volume: 63(5) Pages: 568-573
- NAID
  40019086799
- Data Source
  KAKENHI-PROJECT-23791068
[Journal Article] Neutralization of the γ-secretase activity by monoclonal antibody against extracellular domain of nicastrin2012
- Author(s)
  Hayashi I, Takatori S, Urano Y, Miyake Y, Takagi J, Sakata-Yanagimoto M, Iwanari H, Osawa S, Morohashi Y, Li T, Wong PC, Chiba S, Kodama T, Hamakubo T, Tomita T, Iwatsubo T
- Journal Title
  
  Oncogene
  
  Volume: 31 Pages: 787-798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482
[Journal Article] Early Pathologic findings of bronchiolitis obliterans after allogeneic hematopoietic stem cell transplantations: a proposal from a case2012
- Author(s)
  Nakamoto-Matsubara R
- Journal Title
  
  Case Report Hematol
  
  Volume: 2012 Pages: 957612-957612
- DOI
  10.1155/2012/957612
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791068
[Journal Article] Notch2 and immune function2012
- Author(s)
  Mamiko Sakata-Yanagimoto
- Journal Title
  
  Curr Top Bicrobiol Immunol
  
  Volume: 360 Pages: 151-161
- DOI
  10.1007/82_2012_235
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482, KAKENHI-PROJECT-23791068, KAKENHI-PUBLICLY-23118503
[Journal Article] Notch2 regulates the development of marginal zone B cells through Fos2012
- Author(s)
  Iwahashi S, Maekawa Y, Nishida J, Ishifune C, Kitamura A, Arimochi H, Kataoka K, Chiba S, Shimada M, Yasutomo K
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 418 Pages: 701-707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482
[Journal Article] Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes2012
- Author(s)
  Sekine C, Koyanagi A, Koyama N, Hozumi K, Chiba S, Yagita H
- Journal Title
  
  Arthritis Res Ther
  
  Volume: Vol.14
- DOI
  10.1186/ar3758
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591085, KAKENHI-PROJECT-23659482
[Journal Article] Identification of unbalanced genome copy number abnormalities in patients with multiple myeloma by single-nucleotide polymorphism genotyping microarray analysis2012
- Author(s)
  Yuhei Kamada
- Journal Title
  
  IntJ Hematol
  
  Volume: 96 Pages: 492-500
- DOI
  10.1007/s12185-012-1171-1
- NAID
  10031126741
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482, KAKENHI-PROJECT-23791068, KAKENHI-PROJECT-24390241, KAKENHI-PUBLICLY-23118503
[Journal Article] Treatment Outcome of Adult Burkitt Lymphoma in Japanese Patients with Modified LMB Protocol : A Single Center Retrospective Analysis2011
- Author(s)
  Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto S, Enami T, Noguchi M, Chiba S
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 51 Issue: 2 Pages: 109-114
- DOI
  10.3960/jslrt.51.109
- NAID
  10030207641
- ISSN
  1346-4280, 1880-9952
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482, KAKENHI-PROJECT-23791068
[Journal Article] Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol : a single center retrospective analysis2011
- Author(s)
  Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto M, Enami T, Noguchi M, Chiba S
- Journal Title
  
  J Clin Exp Hematop
  
  Volume: 51(2) Pages: 109-114
- NAID
  10030207641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23791068
[Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia2011
- Author(s)
  Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, Sato Y, Sato-Otsubo A, Kon A, Nagasaki M, Chalkidis G, Suzuki Y, Shiosaka M, Kawahata R, Yamaguchi T, Otsu M, Obara N, Sakata-Yanagimoto M, Ishiyama K, Mori H, Nolte F, Hofmann WK, Miyawaki S, Sugano S, Haferlach C, Koeffler HP, Shih LY, Haferlach T, Chiba S, Nakauchi H, Miyaho S, Ogawa S
- Journal Title
  
  Nature
  
  Volume: 478 Pages: 64-69
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134006
[Journal Article] Treatment outcome of adult Burkitt lymphoma in Japanese patients with modified LMB protocol: a single center retrospective analysis.2011
- Author(s)
  Nishikii H, Nakamura N, Kondo Y, Okoshi Y, Suzukawa K, Hasegawa Y, Yokoyama Y, Sakata-Yanagimoto S, Enami T, Noguchi M, Chiba S
- Journal Title
  
  J Clin Exp Hematopathol
  
  Volume: 51 Pages: 109-114
- NAID
  10030207641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482
[Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine2011
- Author(s)
  Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami- Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S.
- Journal Title
  
  Blood
  
  Volume: 117 Pages: 128-134
- NAID
  120002836909
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191
[Journal Article] Procoagulant properties of microparticles released from red blood cells in paroxysmal nocturnal haemoglobinuria2011
- Author(s)
  Yukinori Kozuma
- Journal Title
  
  British Journal of Haematology
  
  Volume: 152 Pages: 631-639
- DOI
  10.1111/j.1365-2141.2010.08505.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191, KAKENHI-PUBLICLY-23118503, KAKENHI-PROJECT-23659482
[Journal Article] The LRF transcription factor regulates mature B cell development and the germinal center response in mice2011
- Author(s)
  Sakurai N, Maeda M, Lee SU, Ishikawa Y, Li M, Williams JC, Wang L, Su L, Suzuki M, Saito TI, Chiba S, Casola S, Yagita H, Teruya-Feldstein J, Tsuzuki S, Bhatia R, Maeda T.
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Pages: 2583-2598
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482
[Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia., Nature2011
- Author(s)
  Kenichi Yoshida
- Journal Title
  
  Nature
  
  Volume: 478 Pages: 332-339
- DOI
  10.1038/nature10496
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22134004, KAKENHI-PROJECT-22390191, KAKENHI-PROJECT-22659058, KAKENHI-PROJECT-22790895, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23118503, KAKENHI-PROJECT-23390269, KAKENHI-PROJECT-23659482, KAKENHI-PROJECT-23659533, KAKENHI-PROJECT-23791068, KAKENHI-PROJECT-23791075
[Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine2011
- Author(s)
  Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S
- Journal Title
  
  Blood
  
  Volume: 117(1) Pages: 128-34
- NAID
  120002836909
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Notch2 signaling is required for proper mast cell distribution and mucosal immunity in the intestine2011
- Author(s)
  Sakata-Yanagimoto M, Sakai T, Miyake Y, Saito TI, Maruyama H, Morishita Y, Nakagami-Yamaguchi E, Kumano K, Yagita H, Fukayama M, Ogawa S, Kurokawa M, Yasutomo K, Chiba S
- Journal Title
  
  Blood
  
  Volume: 117(1) Pages: 128-34
- NAID
  120002836909
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130002
[Journal Article] Notch-dependent and-independent regulation of mature B cell lineage fate and humoral immune response by the LRF transcription factor homodimer2011
- Author(s)
  Nagisa Sakurai
- Journal Title
  
  J Clin Invest
  
  Volume: 121 Pages: 2581-2598
- DOI
  10.1172/jci45682
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130002, KAKENHI-PROJECT-22390191, KAKENHI-PROJECT-22591027, KAKENHI-PUBLICLY-23118503, KAKENHI-PROJECT-23659482
[Journal Article] c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver2011
- Author(s)
  Kusakabe M, Hasegawa K, Hamada M, Nakamura M, Ohsumi T, Suzuki H, Mai TT, Kudo T, Uchida K, Ninomiya H, Chiba S, Takahashi S
- Journal Title
  
  Blood
  
  Volume: 118 Pages: 1374-1385
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23659482
[Journal Article] Treatment of central nervous system lymphoma in rats with intraventricular rituximab and serum2010
- Author(s)
  Miyake Y, Okoshi Y, Machino T, Chiba S.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 92 Pages: 474-480
- NAID
  10027673501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191
[Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia2010
- Author(s)
  Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
- Journal Title
  
  Blood
  
  Volume: 115(14) Pages: 2872-2881
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130002
[Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia2010
- Author(s)
  Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S
- Journal Title
  
  Blood
  
  Volume: 115(14) Pages: 2872-2881
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone hemostasis2010
- Author(s)
  Miyauchi Y, Ninomiya K, Miyamoto H, Sakamoto A, Iwasaki R, Hoshi H, Miyamoto K, Hao W, Yoshida S, Morioka H, Chiba K, Kato S, Tokuhisa T, Saitou M, Toyama Y, Suda T, Miyamoto T
- Journal Title
  
  J Exp Med
  
  Volume: 207 Pages: 751-762
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-22130001
[Journal Article] Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia2010
- Author(s)
  Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, Harada Y, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S.
- Journal Title
  
  Blood 115
  
  Pages: 2878-2881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Hesl immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia2010
- Author(s)
  Nakahara F, Sakata-Yanagimoto M, Komeno Y, Kato N, Uchida T, Haraguchi K, Kumano K, HaradaY, Harada H, Kitaura J, Ogawa S, Kurokawa M, Kitamura T, Chiba S.
- Journal Title
  
  Blood
  
  Volume: 115 Pages: 2872-2881
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191
[Journal Article] Difference in blood tacrolimus concentration between ACMIA and MEIA in samples with low haematocrit values2010
- Author(s)
  Doki K, Homma M, Hori T, Tomita T, Hasegawa Y, Ito S, Fukunaga K, Kaneko M, Chiba S, Sumida T, Ohkohchi N, Kohda Y.
- Journal Title
  
  Journal of Pharmacy and Pharmacology
  
  Volume: 62 Pages: 1185-1188
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191
[Journal Article] A nonradiation-containing, intermediate-dose methotrexate regimen for elderly patients with primary central nervous system lymphoma2010
- Author(s)
  Taoka K, Okoshi Y, Sakamoto N, Takano S, Matsumura A, Hasegawa Y, Chiba S.
- Journal Title
  
  International Journal of Hematology
  
  Volume: 92 Pages: 617-623
- NAID
  10027673973
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191
[Journal Article] Notch2 signaling is required for potent anti-tumor immunity in vivo2010
- Author(s)
  Sugumito K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K.
- Journal Title
  
  Journal of Immunology (印刷中)
  
  Pages: 4673-4678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Notch2 signaling is required for potent anti-tumor immunity in vivo2010
- Author(s)
  Sugimoto K, Maekawa Y, Kitamura A, Nishida J, Koyanagi A, Yagita H, Kojima H, Chiba S, Shimada M, Yasutomo K.
- Journal Title
  
  Journal of Immunology
  
  Volume: 184 Pages: 4673-4678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390191
[Journal Article] Dual antitumor mechanisms of Notch signaling inhibitor in a T cell acute lymph oblastic leukemia xenograft model2009
- Author(s)
  Masuda S, Kumano K, Suzuki T, Tomita T, Iwatsubo T, Natsugari H, Tojo A, Shibutani M, Mitsumori K, Hanazono Y, Ogawa S, Kurokawa M, Chiba S.
- Journal Title
  
  Cancer Science 100
  
  Pages: 2444-2450
- NAID
  10027198807
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Gain-of-function of mutated c-Cbl tumor suppressor associated with myeloid neoplasms having 11q UPD2009
- Author(s)
  Sanada M, Suzuki T, Shih LY, Otsu M, Kato M, Yamazaki S, Tamura A, Honda H, Sakata-Yanagimoto M, Kumano K, Oda H, Yamagata T, Takita J, Gotoh N, Nakazaki K, Kawamata N, Onodera M, Nobuyoshi M, Hayashi Y, Harada H, Kurokawa M, Chiba S, Mori H, Ozawa K, Omine M, Hirai H, Nakauchi H, Koeffler HP, Ogawa S.
- Journal Title
  
  Nature 460
  
  Pages: 904-908
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma2009
- Author(s)
  Lee S-y, Kumano K, Nakazaki K, Sanada M, Matsumoto A, Yamamoto C, Nannya Y, Suzuki R, Ota S, Ota Y, Izutsu K, Sakata-Yanagimoto M, Hangaishi A, Yagita H, Fukayama M, Seto M, Kurokawa M, Ogawa S, Chiba S.
- Journal Title
  
  Cancer Science 100
  
  Pages: 920-926
- NAID
  10025145854
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Derivation of functional mature neutrophils from human embryonic stem cells2009
- Author(s)
  Yokoyama Y, Suzuki T, Sakata-Yanagimoto M, Kumano K, Higashi K, Takato T, Kurokawa M, Ogawa S, Chiba S.
- Journal Title
  
  Blood 113
  
  Pages: 6584-6592
- NAID
  120001466696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Notch signaling confers antigen-presenting cell functions on mast cells2009
- Author(s)
  Nakano N, Nishiyama C, Yagita H, Koyanagi A, Akiba H, Chiba S, Ogawa H, Okumura K.
- Journal Title
  
  J Allergy Clin Immunol 123(1)
  
  Pages: 74-81
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Notch Activation Induces the Generation of Functional NK Cells from Human Cord Blood CD34-Positive Cells Devoid of IL-152009
- Author(s)
  Haraguchi K, Suzuki T, Koyama N, Kumano K, Nakahara F, Matsumoto A, Yokoyama Y, Sakata-Yanagimoto M, Masuda S, Takahashi T, Kamijo A, Takahashi K, Takanashi M, Okuyama Y, Yasutomo K, Sakano S, Yagita H, Kurokawa M, Ogawa S, Chiba S.
- Journal Title
  
  Journal of Immunology 182
  
  Pages: 6168-6178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Jagged1 suppresses collagen-induced arthritis by indirectly providing a negative signal in CD8+ T cells.2009
- Author(s)
  Kijima M, Iwata A, Maekawa Y, Uehara H, Izumi K, Kitamura A, Yagita H, Chiba S, Shiota H, Yasutomo K.
- Journal Title
  
  J Immunol 182(6)
  
  Pages: 3566-3572
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Frequent inactivation of A20 in B-cell lymphomas2009
- Author(s)
  Kato M, Sanada M, Kato I, Sato Y, Takita J, Takeuchi K, Niwa A, Chen Y, Nakazaki K, Nomoto J, Asakura Y, Muto S, Tamura A, Iio M, Akatsuka Y, Hayashi Y, Mori H, Igarashi T, Kurokawa M, Chiba S, Mori S, Ishikawa Y, Okamoto K, Tobinai K, Nakagama H, Nakahata T, Yoshino T, Kobayashi Y, Ogawa S.
- Journal Title
  
  Nature 459
  
  Pages: 712-716
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20015010
[Journal Article] Notch 2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity2008
- Author(s)
  Maekawa Y, Minato Y, Ishifune C, Kurihara T, Kitamura A, Kojima H, Yagita H, Sakata-Yanagimoto S, Saito T, Taniuchi I, Chiba S, Sone S, Yasutomo K
- Journal Title
  
  Nat Immunol 9(10)
  
  Pages: 1140-1147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Regulation Of Notch Signaling By Dynamic Changes In The Precision In S3 Cleavage Of Notch-1.2008
- Author(s)
  Tagami S, Okochi M, Yanagida K, Ikuta A, Fukumori A, Matsumoto N, Ishizuka-Katsura Y, Nakayama T, Itoh N, Jiang J, Nishitomi K, Kamino K, Morihara T, Hashimoto R, Tanaka T, Kudo T, Chiba S, Takeda M.
- Journal Title
  
  Mol Cell Biol 28(1)
  
  Pages: 165-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells2008
- Author(s)
  Goyama S, Yamamoto G, Sato T, Ichikawa M, Ogawa S, Chiba S, Kurokawa M.
- Journal Title
  
  Cell Stem Cell 3(2)
  
  Pages: 207-220
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate2008
- Author(s)
  Sakata-Yanagimoto M, Nakagami- Yamaguchi E, Saito T, Kumano K, Yasutomo K, Ogawa S, Kurokawa M, Chiba S.
- Journal Title
  
  Proc Natl Acad Sci USA 105(22)
  
  Pages: 7839-7844
- NAID
  120001356288
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL2008
- Author(s)
  8. Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, Mashimo Y, Oguro H, Nitta E, Ito K, Miyamoto K, Yoshiwara H, Hosokawa K, Nakamura Y, Gomei Y, Iwasaki H, Hayashi Y, Matsuzaki Y, Nakayama K, Ikeda Y, Hata A, Chiba S, Nakayama KI, Suda T.
- Journal Title
  
  Genes Dev 22(8)
  
  Pages: 986-991
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] AML1-Evi-1 specifically transforms hematopoietic stem cells through fusion of the entire Evi-1 sequence to AML12008
- Author(s)
  Takeshita M, Ichikawa M, Nitta E, Goyama S, Asai T, Ogawa S, Chiba S, Kurokawa M.
- Journal Title
  
  Leukemia 22(6)
  
  Pages: 1241-1249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] Dendritic cell-mediated NK cell activation is controlled by Jagged2-Notch interaction2008
- Author(s)
  Kijima M, Yamaguchi T, Ishifune C, Maekawa Y, Koyanagi A, Yagita H, Chiba S, Kishihara K, Shimada M, Yasutomo K.
- Journal Title
  
  Proc Natl Acad Sci USA 105(19)
  
  Pages: 7010-7015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390258
[Journal Article] A high incidence of late-onset neutropenia following rituximab-containing chemotherapy as a primary treatment for CD20-positive β-cell lymphoma : a single institution study.2007
- Author(s)
  Nitta E, Izutsu K, Sato T, Ota Y, Takeuchi K, Kamijo A, Takahashi K, Oshima K, Kanda Y, Chiba S, Motokura T, Kurokawa M.
- Journal Title
  
  Annals of Oncology 18
  
  Pages: 364-369
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Notch signaling in stem cell systems.2006
- Author(s)
  Chiba S
- Journal Title
  
  Stem Cells 24
  
  Pages: 2437-2447
- Data Source
  KAKENHI-PROJECT-18659276
[Journal Article] DC1d expression level in tumor cells is an important determinant for antitumor immunity by natural killer T cells.2006
- Author(s)
  Haraguchi K, Takahashi T, Nakahara F, Matsumoto A, Kurokawa M, Ogawa S, Oda H, Hirai H, Chiba S.
- Journal Title
  
  Leuk Lymphoma 47
  
  Pages: 2218-2223
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Highly efficient ex vivo expansion of human hematopoietic stem cells using Deltal-Fc chimeric protein.2006
- Author(s)
  Suzuki T, Yokoyama Y, Kumano K, Takanashi M, Kozuma S, Takato T, Nakahata T, Nishikawa M, Sakano S, Kurokawa M, Ogawa S, Chiba S.
- Journal Title
  
  Stem Cells 24
  
  Pages: 2456-2465
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization.2006
- Author(s)
  Hosoya N, Sanada M, Nannya Y, Nakazaki K, Wang L, Hangaishi A, Kurokawa M, Chiba S, Ogawa S.
- Journal Title
  
  Genes Chromosomes Cancer 45
  
  Pages: 482-494
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Genome-wide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization.2006
- Author(s)
  Hosoya N, Sanada M, Nannya Y, Nakazaki K, Wang L, Hangaishi A, Kurokawa A, Chiba S, Ogawa S.
- Journal Title
  
  Genes Chromosomes Cancer 45
  
  Pages: 482-494
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390272
[Journal Article] Pharmacokinetics of alemtuzumab after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab with or without CD52-positive malignancies.2006
- Author(s)
  Oshima K, Kanda Y, Nakahara F, Shoda E, Suzuki T, Imai Y, Watanabe T, Asai T, Izutsu K, Ogawa S, Motokura T, Chiba S, Kurokawa M.
- Journal Title
  
  Am J Hematol 81
  
  Pages: 875-879
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Genomewide screening of DNA copy number changes in chronic myelogenous leukemia with the use of high-resolution array-based comparative genomic hybridization.2006
- Author(s)
  Hosoya N, Sanada M, Nannya Y, Nakazaki K, Wang L, Hangaishi A, Kurokawa M, Chiba S, Ogawa S.
- Journal Title
  
  Genes Chromosomes Cancer. 45(5)
  
  Pages: 482-494
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590924
[Journal Article] Notch signaling in stem cell systems.2006
- Author(s)
  Chiba S
- Journal Title
  
  Stem Cells 24
  
  Pages: 2437-2447
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Notch signaling in stem cell systems.2006
- Author(s)
  Chiba S.
- Journal Title
  
  Stem Cells 24
  
  Pages: 2437-2447
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] AML1/Runx1 rescues Notchl-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis.2006
- Author(s)
  Nakagawa M, Ichikawa M, Kumano K, Goyama S, Kawazu M, Asai T, Ogawa S, Kurokawa M, Chiba S.
- Journal Title
  
  Blood 108
  
  Pages: 3329-3334
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations.2006
- Author(s)
  Nishiyama U, Yoshino T, Ozai M, Yoshioka R, Fujisawa M, Ogasawara Y, Kitahori M, Yoshioka E, Kubo K, Komeno Y, Kurokawa M, Ogawa S, Chiba S, Ogawa T, Kuwaki T, Hirai H, Miwa A.
- Journal Title
  
  Leuk Res 30
  
  Pages: 1541-1546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Preservation of ovarian function by ovarian shielding when undergoing total body irradiation for hematopoietic stem cell transplantation : a report of two successful cases.2006
- Author(s)
  Nakagawa K, Kanda Y, Yamashita H, Hosoi Y, Oshima K, Ohtomo K, Ban N, Yamakawa S, Nakagawa S, Chiba S.
- Journal Title
  
  Bone Marrow Transplant 37
  
  Pages: 583-587
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Treatment results of chemoradiation therapy for localized aggressive lymphomas : a retrospective 20-year study2006
- Author(s)
  Yamashita H, Izutsu K, Nakamura N, Shiraishi K, Chiba S, Kurokawa M, Tago M, Igaki H, Ohtomo K, Nakagawa K.
- Journal Title
  
  Ann Hematol 85
  
  Pages: 523-529
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Notch signaling in stem cell systems.2006
- Author(s)
  Chiba S
- Journal Title
  
  Stem Cells 24
  
  Pages: 2437-2447
- Data Source
  KAKENHI-PROJECT-18013012
[Journal Article] Pharmacokinetics of ganciclovir in haematopoietic stem cell transplantation recipients with or without renal impairment.2006
- Author(s)
  Asano-Mori Y, Kanda Y, Oshima K, Watanabe T, Shoda E, Motokura T, Kurokawa M, Chiba S.
- Journal Title
  
  J Anthnicrob Chemother 57
  
  Pages: 1004-1007
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Mutations of the Notchl gene in T-cell acute lymphoblastic leukemia : analysis in adults and children.2005
- Author(s)
  Lee SY, Chiba S, et al.
- Journal Title
  
  Leukemia 19
  
  Pages: 1841-1843
- Data Source
  KAKENHI-PROJECT-17014023
[Journal Article] A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays.2005
- Author(s)
  Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, Kurokawa M, Chiba S, Bailey DK, Kennedy GC, Ogawa S.
- Journal Title
  
  Cancer Res. 65(14)
  
  Pages: 6071-6079
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590924
[Journal Article] Ki23819 inhibits kinase activity of wild type and mutant FLT3 receptor tyrosine kinase in vitro.2005
- Author(s)
  Komeno Y, Kurokawa M, Imai Y, Takeshita M, Matsumura T, Kubo K, Yoshino T, Nishiyama U, Kuwaki T, Kubo K, Ogawa T, Ogawa S, Chiba S, Miwa A, Hirai H.
- Journal Title
  
  Leukemia 19
  
  Pages: 930-935
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Functional Domains of Runx1 Are Differentially Required for CD4 Repression, TCR{beta} Expression, CD4/8 Double-Negative to CD4/8 Double-Positive Transition in Thymocyte Development.2005
- Author(s)
  Kawazu M, Asai T, Ichikawa M, Yamamoto G, Saito T, Goyama S, Mitani K, Miyazono K, Chiba S, Ogawa S, Kurokawa M, Hirai H.
- Journal Title
  
  J.Immunol. 174
  
  Pages: 3526-3533
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390272
[Journal Article] Host-residual in variant NK T cells attenuate graft-versus-host immunity.2005
- Author(s)
  Haraguchi K, Chiba S, et al.
- Journal Title
  
  J Immunol 175
  
  Pages: 1320-1328
- Data Source
  KAKENHI-PROJECT-17014023
[Journal Article] Functional domains of Runx1 are differentially required for CD4 repression, TCRβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development.2005
- Author(s)
  Kawazu M, Chiba S, et al.
- Journal Title
  
  J Immunol 174
  
  Pages: 3526-3533
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] High-grade cytomegalovirus antigenemia after hematopoietic stem cell transplantation.2005
- Author(s)
  Asano-Mori Y, Oshima K, Sakata-Yanagimoto M, Nakagawa M, Kandabashi K, Izutsu K, Hangaishi A, Motokura T, Chiba S, Kurokawa M, Hirai H, Kanda Y.
- Journal Title
  
  Bone Marrow Transplant 36
  
  Pages: 813-819
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Functional domains of Runxl are differentially required for CD4 repression, TCRIβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development.2005
- Author(s)
  Kawazu M, Chiba S, et al.
- Journal Title
  
  J Immunol 174
  
  Pages: 3526-3533
- Data Source
  KAKENHI-PROJECT-17014023
[Journal Article] Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP.2005
- Author(s)
  Nitta E, Izutsu K, Yamaguchi Y, Imai Y, Ogawa S, Chiba S, Kurokawa M, Hirai H.
- Journal Title
  
  Oncogene 24
  
  Pages: 6165-6173
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation.2005
- Author(s)
  Hosoya N, Qiao Y, Hangaishi A, Wang L, Nannya Y, Sanada M, Kurokawa M, Chiba S, Hirai H, Ogawa S.
- Journal Title
  
  Genes Chromosomes Cancer 42(3)
  
  Pages: 269-279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590924
[Journal Article] The Notch1 oncoprotein antagonizes TGF-β/Smad-mediated cell growth suppression via sequestration of co-activator p300.2005
- Author(s)
  Masuda S, Chiba S, et al.
- Journal Title
  
  Cancer Science 96
  
  Pages: 274-282
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia : analysis in adults and children.2005
- Author(s)
  Lee SY, Chiba S, et al.
- Journal Title
  
  Leukemia 19
  
  Pages: 1841-1843
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery.2005
- Author(s)
  Crcareva A, Chiba S, et al.
- Journal Title
  
  Exp Hematol 33
  
  Pages: 1459-1469
- Data Source
  KAKENHI-PROJECT-17014023
[Journal Article] Functional domains of Runx1 are differentially required for CD4 repression, TCRβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development.2005
- Author(s)
  Kawazu M, Chiba S, et al.
- Journal Title
  
  J Immunol 174
  
  Pages: 3526-3533
- Data Source
  KAKENHI-PROJECT-17659288
[Journal Article] Notch signaling in hematopoietic stem cells.2005
- Author(s)
  Suzuki T, Chiba S
- Journal Title
  
  Intl J Hematol 82
  
  Pages: 285-294
- NAID
  10016878610
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] The Notch1 oncoprotein antagonizes TGF-β/Smad-mediated cell growth suppression via sequestration of co-activator p300.2005
- Author(s)
  Masuda S, Chiba S, et al.
- Journal Title
  
  Cancer Science 96
  
  Pages: 274-282
- Data Source
  KAKENHI-PROJECT-17659288
[Journal Article] Mutations of the Notch1 gene in T-cell acute lymphoblastic leukemia : analysis in adults and children.2005
- Author(s)
  Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K, Kurokawa M, Hayashi Y, Ogawa S, Chiba S.
- Journal Title
  
  Leukemia 19(10)
  
  Pages: 1841-1843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590924
[Journal Article] Mutations of the Notch1 gene in T -cell acute lymphoblastic leukemia : analysis in adults and children.2005
- Author(s)
  Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K, Kurokawa M, Hayashi Y, Ogawa S, Chiba S.
- Journal Title
  
  Leukemia 19
  
  Pages: 1841-1843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390272
[Journal Article] Host-residual invariant NK T cells attenuate graft-versus-host immunity.2005
- Author(s)
  Haraguchi K, Chiba S, et al.
- Journal Title
  
  J Inununol 175
  
  Pages: 1320-1328
- Data Source
  KAKENHI-PROJECT-17659288
[Journal Article] Identification of a SRC-like tyrosine kinase gene, FRK, fused with ETV6 in a patient with acute myelogenous leukemia carrying a t(6;12)(q21;p13) translocation.2005
- Author(s)
  Hosoya N, Qiao Y, Hangaishi A, Wang L, Nannya Y, Sanada M, Kurokawa M, Chiba S, Hirai H, Oagwa S.
- Journal Title
  
  Genes Chromosomes Cancer 42
  
  Pages: 269-279
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390272
[Journal Article] Cardiac complications after haploidentical HLA-mismatched hematopoietic stem cell transplantation using in vivo alemtuzumab.2005
- Author(s)
  Oshima K, Sakata-Yanagimoto M, Asano-Mori Y, Izutsu K, Watanabe T, Shoda E, Ogawa S, Motokura T, Chiba S, Kurokawa M, Hirai H, Kanda Y.
- Journal Title
  
  Bone Marrow Transplant 36
  
  Pages: 821-824
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery.2005
- Author(s)
  Crcareva A, Chiba S, et al.
- Journal Title
  
  Exp Hematol 33
  
  Pages: 1459-1469
- Data Source
  KAKENHI-PROJECT-17659288
[Journal Article] The Notchl oncoprotein antagonizes TGF-β/Smad-mediated cell growth suppression via sequestration of co-activator p300.2005
- Author(s)
  Masuda S, Chiba S, et al.
- Journal Title
  
  Cancer Science 96
  
  Pages: 274-282
- Data Source
  KAKENHI-PROJECT-17014023
[Journal Article] Mutations of the Notchl gene in T-cell acute lymphoblastic leukemia : analysis in adults and children.2005
- Author(s)
  Lee SY, Kumano K, Masuda S, Hangaishi A, Takita J, Nakazaki K, Kurokawa M, Hayashi Y, Ogawa S, Chiba S.
- Journal Title
  
  Leukemia 19
  
  Pages: 1841-1843
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays.2005
- Author(s)
  Nannya Y, Sanada M, Nakazaki K, Hosoya N, Wang L, Hangaishi A, Kurokawa M, Chiba S, Bailey DK, Kennedy GC, Ogagwa S.
- Journal Title
  
  Cancer Res. 65
  
  Pages: 6071-6079
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390272
[Journal Article] Notch signaling in hematopoietic stem cells.2005
- Author(s)
  Suzuki T, Chiba S.
- Journal Title
  
  Intl J Hematol 82
  
  Pages: 285-294
- NAID
  10016878610
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery.2005
- Author(s)
  Crcareva A, Chiba S, et al.
- Journal Title
  
  Exp Hematol 33
  
  Pages: 1459-1469
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance.2005
- Author(s)
  Seo S, Asai T, Saito T, Suzuki T, Morishita Y, Nakamoto T, Ichikawa M, Yamamoto G, Kawazu M, Yamagata T, Sakai R, Mitani K, Ogawa S, Kurokawa M, Chiba S, Hirai H.
- Journal Title
  
  J Immunol 175
  
  Pages: 3492-3501
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery.2005
- Author(s)
  Crcareva A, Saito T, Kunisato A, Kumano K, Suzuki T, Sakata-Yanagimoto M, Kawazu M, Stojanovic A, Kurokawa M, Ogawa S. Chiba S.
- Journal Title
  
  Exp Hematol 33
  
  Pages: 1459-1469
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Journal Article] Stem cell leukemia protein directs hematopoietic stem cell fate.2004
- Author(s)
  Kunisato A, Chiba S, et al.
- Journal Title
  
  Blood 103
  
  Pages: 3336-3341
- Data Source
  KAKENHI-PROJECT-13218021
[Journal Article] Runx1/AML-1 ranks as a master regulator of adult hematopoiesis.2004
- Author(s)
  Ichikawa M, Asai T, Chiba S, Kurokawa M, Oagwa S.
- Journal Title
  
  Cell Cycle 3
  
  Pages: 722-724
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390272
[Journal Article] Recovery of Valpha24(+) NKT cells after hematopoietic stem cell transplantation.2004
- Author(s)
  Haraguchi K, Chiba S, et al.
- Journal Title
  
  Bone Marrow Transplant 34
  
  Pages: 595-602
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.2004
- Author(s)
  Ichikawa M, Chiba S, et al.
- Journal Title
  
  Nature Med 10
  
  Pages: 299-304
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] AML1 Is Functionally Regulated through p300-mediated Acetylation on Specific Lysine Residues.2004
- Author(s)
  Yamaguchi Y, Chiba S, et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 15630-15638
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] AML1 Is Functionally Regulated through p300-mediated Acetylation on Specific Lysine Residues.2004
- Author(s)
  Yamaguchi Y, Chiba S, et al.
- Journal Title
  
  J Biol Chem 279
  
  Pages: 15630-15638
- Data Source
  KAKENHI-PROJECT-13218021
[Journal Article] Recovery of Valpha24(+) NKT cells after hematopoietic steal cell transplantation.2004
- Author(s)
  Haraguchi K, Chiba S, et al.
- Journal Title
  
  Bone Marrow Transplant 34
  
  Pages: 595-602
- Data Source
  KAKENHI-PROJECT-13218021
[Journal Article] AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.2004
- Author(s)
  Ichikawa M, Asai T, Saito T, Yamamoto G, Seo S, Yamazaki I, Yamagata T, Mitani K, Chiba S, Ogawa S, Kurokawa M, Hirai H.
- Journal Title
  
  Nature Med 10
  
  Pages: 299-304
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Stem cell leukemia protein directs hematopoietic stem cell fate.2004
- Author(s)
  Kunisato A, Chiba S, et al.
- Journal Title
  
  Blood 103
  
  Pages: 3336-3341
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis.2004
- Author(s)
  Ichikawa M, Chiba S, et al.
- Journal Title
  
  Nature Med 10
  
  Pages: 299-304
- Data Source
  KAKENHI-PROJECT-13218021
[Journal Article] Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable for Marginal Zone B Lineage Development.2003
- Author(s)
  Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto GS Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H.
- Journal Title
  
  Immunity 18
  
  Pages: 675-685
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Notch but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells.2003
- Author(s)
  Kumano K, Chiba S, et al.
- Journal Title
  
  Immunity 18
  
  Pages: 699-711
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Notch2 Is Preferentially Expressed in Mature B Cells and Indispensable or Marginal Zone B Lineage Development.2003
- Author(s)
  Saito T, Chiba S, et al.
- Journal Title
  
  Immunity 18
  
  Pages: 675-685
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo.2003
- Author(s)
  Kunisato A, Chiba S, et al.
- Journal Title
  
  Blood 101
  
  Pages: 1777-1783
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] HES-1 preserves purified hematopoietic stem cells ex vive and accumulates side population cells in vivo.2003
- Author(s)
  Kunisato A, Chiba S, Nakagami-Yamaguchi E, Kumano K, Saito T, Masuda S, Yamaguchi T, Osawa M, Kageyama R, Nakauchi H, Nishikawa M, Hirai H.
- Journal Title
  
  Blood 101
  
  Pages: 1777-1783
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells.2003
- Author(s)
  Kumano K, Chiba S, Kunisato A, Sata M, Saito T, Nakagami-Yamaguchi E, Yamaguchi T, Masuda S, Shimizu K, Takahashi T, Ogawa S, Hamada Y, Hirai H.
- Journal Title
  
  Immunity 18
  
  Pages: 699-711
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of Notch2 intracellular domain.2002
- Author(s)
  Shimizu K, Chiba S, Saito T, Takahashi T, Kumano K, Hamada Y, Hirai H.
- Journal Title
  
  EMBO J 21
  
  Pages: 294-302
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Analysis of human Va24+CD8+ natural killer T cells activated by a-galactosylceramide-pulsed monocyte-derived dendritic cells.2002
- Author(s)
  Takahashi T, Chiba S, Nieda M, Azuma T, Ishihara S, Shibata Y, Takeo J, Hirai H.
- Journal Title
  
  J Immunol 168
  
  Pages: 3140-3144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Analysis of human Va24+CD8+ natural killer T cells activated by a-galactosylceramide-pulsed monocyte-derived dendritic cells.2002
- Author(s)
  Takahashi T, Chiba S, et al.
- Journal Title
  
  J Immunology 168
  
  Pages: 3140-3144
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of Notch2 intracellular domain.2002
- Author(s)
  Shimizu K, Chiba S, et al.
- Journal Title
  
  EMBO J 21
  
  Pages: 294-302
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantation.
- Author(s)
  Kanda Y, Chiba S, et al.
- Journal Title
  
  Transplantation (in press)
- Data Source
  KAKENHI-PROJECT-13218021
[Journal Article] In vivo alemtuzumab enables haploidentical HLA-mismatched hematopoietic stem cell transplantation without ex vivo graft manipulation.
- Author(s)
  Kanda Y, Chiba S, et al.
- Journal Title
  
  Transplantation (in press)
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] In vivo alemtuzumab enables haploidentical HLA-mismatched hematopoietic stem cell transplantation without ex vivo graft manipulation.
- Author(s)
  Kanda Y, Chiba S, et al.
- Journal Title
  
  Transplantation (in press)
- Data Source
  KAKENHI-PROJECT-13218021
[Journal Article] Graft-versus-tumor effect against advanced pancreatic cancer after allogeneic reduced-intensity stem cell transplantation.
- Author(s)
  Kanda Y, Chiba S, et al.
- Journal Title
  
  Transplantation (in press)
- Data Source
  KAKENHI-PROJECT-14370300
[Journal Article] Unbalanced translocation der(1;7)(q10;p10) defines a unique clinicopathological subgroup of myeloid neoplasms.
- Author(s)
  Sanada M, Uike N, Ohyashiki K, Ozawa K, Lili W, Hangaishi A, Kanda Y, Chiba S, Kurokawa M, Omine M, Mitani K, Ogawa S.
- Journal Title
  
  Leukemia (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390274
[Presentation] Effectiveness of Dasatinib in an Angioimmunoblastic T-Cell Lymphoma Mouse Model2018
- Author(s)
  Tran B. Nguyen, Mamiko Sakata-Yanagimoto, Manabu Fujisawa, Shigeru Chiba
- Organizer
  The 9th JSH International Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Genetic evidence implying the common precursor cells for primary and extra-central nervous system relapsed tumors in primary central nervous system lymphoma2018
- Author(s)
  Keiichiro Hattori, Mamiko Sakata-Yanagimoto, Tohru Nanmoku, Yasuhito Suehara, Ryota Matsuoka, Masayuki Noguchi, Yasuhisa Yokoyama, Takayasu Kato, Naoki Kurita, Hidekazu Nishikii, Naoshi Obara, Shingo Takano, Eiichi Ishikawa, Akira Matsumura, Masafumi Muratani, Yuichi Hasegawa, Shigeru Chiba
- Organizer
  23rd Congress of EHA
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] New waves in graft-versus-host disease control: information posted from Japan2018
- Author(s)
  Shigeru Chiba
- Organizer
  9th Asian Cellular Therapy Organization Meeting
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] TP53 mutations found in the serum of malignant lymphoma patients at remission derive from clonal hematopoiesis rather than minimal residual disease.2018
- Author(s)
  Yasuhito Suehara, Mamiko Sakata-Yanagimoto, Keiichiro Hattori, Taiki Sato, Masayuki Noguchi, Tatsuhiro Sakamoto, Manabu Kusakabe, Naoki Kurita, Takayasu Kato, Yasuhisa Yokoyama, Hidekazu Nishikii, Naoshi Obara, Yuichi Hasegawa, Shigeru Chiba
- Organizer
  2018 ASH Meeting on Lymphoma Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Liquid biopsy for the identification of intravascular large B-cell lymphoma2018
- Author(s)
  末原　泰人, 坂田（柳元）麻実子，服部圭一朗，伊藤孝美，梶　大介，山本　豪，末永孝生，佐藤泰樹，野口雅之，千葉　滋
- Organizer
  第58回　日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Droplet digital PCR and PNA-LNA clamp method for RHOA mutation detection in peripheral T-cell lymphoma2018
- Author(s)
  Sharna Tanzima nuhat, 坂田（柳元）麻実子，小森大輔，服部圭一朗，福本浩太，藤澤　学，末永孝生，若松宏武，島津光伸，千葉　滋
- Organizer
  第58回　日本リンパ網内系学会総会
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Activation of RHOA-VAV1 Signaling Axis in Angioimmunoblastic T-Cell Lymphoma2017
- Author(s)
  Manabu Fujisawa, Mamiko Sakata-Yanagimoto, Shoko Nishizawa, Shigeru Chiba
- Organizer
  22nd Congress of European Hematology Association 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] A novel function of the G17V RHOA mutant in angioimmunoblastic T- cell lymphoma2017
- Author(s)
  坂田（柳元）麻実子，藤澤学，Ngyuen Bich Tran，千葉滋
- Organizer
  第76回日本癌学会学術総会
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Combination of Tet2 loss-of-function and RHOAG17V expression leads to T-cell lymphoma in mice2017
- Author(s)
  Nguyen Bich Tran，Mamiko Sakata-Yanagimoto，Manabu Fujisawa，Shigeru Chiba
- Organizer
  第79回日本血液学会学術集会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Mechanisms of lymphomagenesis by mutant RHOA.2017
- Author(s)
  Shigeru Chiba.
- Organizer
  2017 US-Japan Symposium on Normal/Malignant Hematopoiesis and Novel Therapies for Hematologic Malignancies
- Place of Presentation
  Hilton Waikoloa Village, Waikoloa, HI, USA
- Year and Date
  2017-02-21
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Targeting T-Cell Receptor Signaling Pathway in Angioimmunoblastic T-Cell Lymphoma2017
- Author(s)
  Nguyen Bich Tran，Mamiko Sakata-Yanagimoto，Manabu Fujisawa，Shigeru Chiba
- Organizer
  The American Society of Hematology 59th Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Clonal hematopoiesis as an origin of myeloid and lymphoid cancers2017
- Author(s)
  千葉滋
- Organizer
  第76回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Integrity of TET dioxygenase activity determines leukemic transformation2016
- Author(s)
  Koichiro Maie, Mamiko Sakata-Yanagimoto, Motohiko Oshima, Yaeko Nakajima, Hirotaka Matsui, Takayasu Kato, Hideharu Muto, Haruhiko Koseki, Atsushi Iwama, Shigeru Chiba.
- Organizer
  第76回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜・神奈川県横浜市
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Double inactivation of tet2 and tet4 induces hypomethylating agent-sensitive acute myeloid leukemia.2016
- Author(s)
  Koichiro Maie, Mamiko Sakata-Yanagimoto, Motohiko Oshima, Takayasu Kato, Hideharu Muto, Enguerran Mouly, Olivier A Bernard, Haruhiko Koseki, Atsushi Iwama, Shigeru Chiba
- Organizer
  21th Congress of EHA 2016
- Place of Presentation
  Bella Center, Copenhagen, Denmark
- Year and Date
  2016-06-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Abnormal Increase in a Distinct Subset of Nestin-Expressing Cells in the Bone Marrow of Myelodysplastic Syndromes.2016
- Author(s)
  Luan Cao Sy, Naoshi Obara, Tatsuhiro Sakamoto, Takayasu Kato, Hidekazu Nishikii, Mamiko Sakata-Yanagimoto, Shigeru Chiba.
- Organizer
  The American Society of Hematology 58th Annual Meeting and Exposition
- Place of Presentation
  San Diego Convention Center, San Diego, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15359
[Presentation] TET2 mutations: a predisposing factor for myeloid and T-cell malignancies2016
- Author(s)
  Mamiko Sakata-Yanagimoto, Koichiro Maie, Bich Tran Nguyen, Shigeru Chiba.
- Organizer
  第76回　日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜・神奈川県横浜市
- Year and Date
  2016-10-06
- Invited
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] 多段階的遺伝子変異獲得による血液がんの発症メカニズム.2016
- Author(s)
  坂田（柳元）麻実子，真家紘一郎，Nguyen Tran，千葉　滋.
- Organizer
  第39回　日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜・神奈川県横浜市
- Year and Date
  2016-11-30
- Invited
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Recurrent VAV1 Abnormalities in Angioimmunoblastic T Cell Lymphoma.2016
- Author(s)
  Daisuke Komori, Mamiko Sakata-Yanagimoto, Sharna Tanzima Nuhat, Kota Fukumoto, Manabu Fujisawa, Shoko Nishizawa, Kosei Matsue, Koji Izutsu, Naoya Nakamura, Kenichi Yoshida, Seishi Ogawa, Shigeru Chiba.
- Organizer
  The American Society of Hematology 58th Annual Meeting and Exposition
- Place of Presentation
  San Diego Convention Center, San Diego, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Localization of distinct subsets of nestin-expressing cells in human bone marrow and their abnormalities in myelodysplastic syndromes2016
- Author(s)
  Luan Cao Sy, Naoshi Obara, Tatsuhiro Sakamoto, Takayasu Kato, Hidekazu Nishikii, Satoshi Ikeda, Keiko Suzuki, Shigeru Chiba.
- Organizer
  The 14th Stem Cell Research Symposium
- Place of Presentation
  淡路夢舞台（兵庫県淡路市）
- Year and Date
  2016-05-20
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15359
[Presentation] Unveiling the Molecular Pathogenesis of Angioimmunoblastic T-cell Lymphoma Using Laser Microdissection Based Sequencing2016
- Author(s)
  Tran B. Nguyen, Yukitsugu Asabe, Mamiko Sakata-Yanagimoto, Shigeru Chiba
- Organizer
  The 35th Sapporo International Cancer Symposium 2016 Cancer Epigenome: From discovery to translation
- Place of Presentation
  ロイトン札幌・北海道札幌市
- Year and Date
  2016-06-24
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Localization and Characteristic of Nestin-expressing Cells in Human Bone Marrow and Their Abnormalities in Myelodysplastic Syndromes.2016
- Author(s)
  Luan Cao Sy, Naoshi Obara, Tatsuhiro Sakamoto, Takayasu Kato, Hidekazu Nishikii, Satoshi Ikeda, Keiko Suzuki, Shigeru Chiba.
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  ヒルトン東京ベイ（千葉県浦安市）
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15359
[Presentation] 血液がんの起源と進展のメカニズム.2016
- Author(s)
  坂田（柳元）麻実子，千葉　滋.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜・神奈川県横浜市
- Year and Date
  2016-10-13
- Invited
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Aging and TET Dioxygenases in Leukemo/lymphomagenesis.2016
- Author(s)
  Shigeru Chiba.
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  ヒルトン東京ベイ・千葉県浦安市
- Year and Date
  2016-07-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Unveiling the molecular pathogenesis of Angioimmunoblastic T-cell lymphoma using laser microdissection based sequencing.2016
- Author(s)
  Tran B. Nguyen坂田（柳元）麻実子，千葉　滋浅部幸成，坂田（柳元）麻実子，千葉　滋.
- Organizer
  第56回　日本リンパ網内系学会総会
- Place of Presentation
  ホテル日航熊本・熊本県熊本市
- Year and Date
  2016-09-01
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Combined Loss of Tet2/Tet3 Dioxygenases Induces Acute Myeloid Leukemia Sensitive to Hypomethylating Agents.2016
- Author(s)
  Koichiro Maie, Mamiko Sakata-Yanagimoto, Motohiko Oshima, Yaeko Nakajima-Takagi, Hirotaka Matsui, Takayasu Kato, Hideharu Muto, Enguerran Mouly, Olivier A Bernard, Haruhiko Koseki, Atsushi Iwama, Shigeru Chiba
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  ヒルトン東京ベイ・千葉県浦安市
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] NOTCH signaling in bone marrow nestin-expressing cells is involved in regulating erythropoiesis.2016
- Author(s)
  坂本竜弘，小原　直，藤村亮介，加藤貴康，Luan Cao Sy，錦井秀和，坂田（柳元）麻実子，高橋　智，千葉　滋.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K15359
[Presentation] Notch Signaling in Bone Marrow Nestin-Expressing Cells Controls Balance of Erythropoiesis at the Bone Marrow and Spleen.2016
- Author(s)
  Tatsuhiro Sakamoto, Naoshi Obara, Takayasu Kato, Luan Cao Sy, Hidekazu Nishikii, Mamiko Sakata-Yanagimoto, Satoru Takahashi, Shigeru Chiba.
- Organizer
  The American Society of Hematology 58th Annual Meeting and Exposition
- Place of Presentation
  San Diego Convention Center, San Diego, CA, USA
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15359
[Presentation] Understanding the Molecular Pathogenesis of Peripheral T-cell Lymphoma by Laser Microdissection-based Sequencing.2016
- Author(s)
  Tran B. Nguyen, Mamiko Sakata-Yanagimoto, Yukitsugu Asabe, Kenichi Yoshida, Koji Izutsu, Naoya Nakamura, Kengo Takeuchi, Seishi Ogawa, Shigeru Chiba
- Organizer
  The 5th JCA-AACR Special Joint Conference
- Place of Presentation
  ヒルトン東京ベイ・千葉県浦安市
- Year and Date
  2016-07-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] Combined loss of Tet2 and Tet3 induces AML sensitive to hypomethylating agents.2016
- Author(s)
  Koichiro Maie, Mamiko Sakata-Yanagimoto, Motohiko Oshima, Takayasu Kato, Hideharu Muto, Enguerran Mouly, Olivier A. Bernard, Haruhiko Koseki, Atsushi Iwama, Shigeru Chiba.
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜・神奈川県横浜市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-16H02660
[Presentation] TET2 mutations as an initiator of both myeloid and lymphoid blood cancers2015
- Author(s)
  Shigeru Chiba, Mamiko Sakata-Yanagimoto
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01504
[Presentation] Molecular mechanisms of the development of peripheral T-cell lymphoma2015
- Author(s)
  Mamiko Sakata-Yanagimoto, Shigeru Chiba
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム
- Year and Date
  2015-10-16
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01504
[Presentation] G17V Rhoa Mutation in Circulating DNA Is a Useful Marker for Diagnosis of AITL and AITL-Related Lymphoma2015
- Author(s)
  Rie Nakamoto-Matsubara, Mamiko Sakata-Yanagimoto, Tran Nguyen, Junichi Furuta, Takayoshi Ito, Takuya Komeno, Seishi Ogawa, Shigeru Chiba
- Organizer
  The American Society of Hematology 57th Annual Meeting and Exposition
- Place of Presentation
  Orlando, FL, USA
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01504
[Presentation] FFPEを用いた血管免疫芽球型T細胞リンパ腫のRho A遺伝子変異解析2015
- Author(s)
  長尾涼子, 菊池イアーラ幸江，カレーラスジョアキム，宮岡　雅，菊地智樹，松下弘道，安藤　潔，坂田（柳元）麻実子，千葉　滋，中村直哉
- Organizer
  第55回　日本リンパ網内系学会総会
- Place of Presentation
  岡山コンベンションセンター
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PUBLICLY-15H01504
[Presentation] Abnormalities in nestin-expressing bone marrow stromal cells in MDS patients2015
- Author(s)
  Noshi Obara，Tatsuhiro Sakamoto，Luan Cao Sy，Takayasu Kato，Sachie Suzuki，Naoki Kurita，Yasuhisa Yokoyama，Mamiko Sakata，Yuichi Hasegawa，Shigeru Chiba.
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K15359
[Presentation] Multi-step tumorigenesis in peripheral T-cell lymphoma2014
- Author(s)
  Shigeru Chiba, Mamiko Sakata-Yanagimoto
- Organizer
  6th T-cell Lymphoma Forum
- Place of Presentation
  Parc 55 Wyndham（San Francisco, CA, U.S.A.）
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112703
[Presentation] Multi-step tumorigenesis in peripheral T-cell lymphoma2014
- Author(s)
  Shigeru Chiba, Mamiko Sakata-Yanagimoto
- Organizer
  6th T-cell Lymphoma Forum
- Place of Presentation
  Parc 55 Wyndham（San Francisco, CA, U.S.A.）
- Invited
- Data Source
  KAKENHI-PROJECT-25670444
[Presentation] TET2 binds and regulates O-linked N-acetylglucosamine transferase.2013
- Author(s)
  Terukazu Enami, Mamiko-Sakata Yanagimoto, Yukitsugu Asabe, Yasuyuki Miyake, Satoshi Serada, Tetsuji Naka, Hideharu Muto, Hidekazu Nishikii, Yasuhisa Yokoyama, Naoshi Obara, Kazumi Suzukawa, Shigeru Chiba.
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  ロトイン札幌・ニトリ文化ホール・札幌市教育文化会館（札幌）
- Data Source
  KAKENHI-PROJECT-24390241
[Presentation] Decreased repair activity of double strand DNA break by irradiation in the peripheral lymphocyte with aging2013
- Author(s)
  Kazumi Suzukawa, Yasushi Kawakami, Shigeru Chiba
- Organizer
  第７５回日本血液学会学術集会
- Place of Presentation
  ロイトン札幌（札幌市）
- Data Source
  KAKENHI-PROJECT-23590659
[Presentation] Hypermethylation of Bcl6 Is a Potential Cause of Development of Lymphoma with Tfh Features in Tet2 Knockdown Mice2013
- Author(s)
  Hideharu Muto, Mamiko Sakata-Yanagimoto, Yasuyuki Miyake, Genta Nagae, Terukazu Enami, Yuhei Kamada, Kazumi Suzukawa, Naoya Nakamura, Hiroyuki Aburatani, Seishi Ogawa, Shigeru Chiba.
- Organizer
  The American Society of Hematology 55th Annual Meeting and Exposition
- Place of Presentation
  Ernest N Morial Convention Center (New Orleans, LA, U.S.A.)
- Data Source
  KAKENHI-PROJECT-24390241
[Presentation] 悪性リンパ腫細胞の起源とその進化2013
- Author(s)
  千葉滋、坂田(柳元)麻実子
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Invited
- Data Source
  KAKENHI-PROJECT-24390241
[Presentation] Decreased repair activity of double-strand DNA break by irradiation in the peripheral lymphocyte with aging2013
- Author(s)
  Kazumi Suzukawa, Yasushi Kawakami, Shigeru Chiba
- Organizer
  第75回日本血液学会学術集会
- Place of Presentation
  ロイトン札幌、札幌
- Year and Date
  2013-10-12
- Data Source
  KAKENHI-PROJECT-23590659
[Presentation] 国際的な臍帯血バンクネットワークを基盤とした臍帯血のやり取り2012
- Author(s)
  栗田尚樹, Francesco Frassoni, Nicoletta Sacchi, Claudia Cossu, Alberto Serio, Canieda Cilloni, 千葉滋, Maria Podesta
- Organizer
  第34回日本造血幹細胞移植学会
- Place of Presentation
  大阪
- Data Source
  KAKENHI-PROJECT-23659482
[Presentation] Role of TET2-mediated DNA oxygenation in hematopoiesis2012
- Author(s)
  Shigeru Chiba
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路島
- Data Source
  KAKENHI-PROJECT-23791068
[Presentation] Profiling of multiple gene mutations in myelodysplastic syndromes using high-throughput resequenceing combined with barcode labeling2010
- Author(s)
  Nagata Y, Sanada M, Yoshida K, Nakaya T, Matsubara A, Obara N, Ishiyama N, Miyawaki S, Takita J, Chiba S, Shih L-Y, Koeffler HP, Ogawa S.
- Organizer
  The American Society of Hematology 52nd Annual Meeting
- Place of Presentation
  オーランド(米国フロリダ州)
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22390191
[Presentation]2010
- Author(s)
  千葉滋
- Organizer
  日本再生医療学会
- Place of Presentation
  広島
- Year and Date
  2010-03-19
- Data Source
  KAKENHI-PROJECT-20015010
[Presentation] Outcome of methotrexate-based chemotherapy without whole-brain-irradiation in elderly PCNCL2010
- Author(s)
  Taoka K, Okoshi Y, Suzukawa K, Takano S, Matsumura A, Hasewaga Y, Chiba S.
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22390191
[Presentation] Notch signaling as a mediator of myeloid differentiation and leukemic transformation2010
- Author(s)
  Sakata-Yanagimoto M, Chiba S.
- Organizer
  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
- Place of Presentation
  ポートピアホテル(神戸)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22390191
[Presentation] Distinct roles of Notch signaling and Hes-1 on hematopoietic cell differentiation fate2010
- Author(s)
  Chiba S.
- Organizer
  Notch and Stem Cells
- Place of Presentation
  アテネ(ギリシャ)
- Year and Date
  2010-10-04
- Data Source
  KAKENHI-PROJECT-22390191
[Presentation] Whole exome analysis of myelodysplastic syndromes using next-generation resequencing technology2010
- Author(s)
  Yoshida K, Sanada M, Nagata Y, Kawahata R, Kato M, Matsubara A, Takita J, Mori H, Ishiyama K, Ishikawa T, Miyawaki S, Obara N, Chiba S, Ogawa S.
- Organizer
  The American Society of Hematology 52nd Annual Meeting
- Place of Presentation
  オーランド(米国フロリダ州)
- Year and Date
  2010-12-06
- Data Source
  KAKENHI-PROJECT-22390191
[Presentation] Retrospective analysis of BCL2+DCBCL in the rituximab era : multi-center analysis2010
- Author(s)
  Nishikii H, Nakamura N, Kondo Y, Kojima M, Takizawa J, Hasegawa Y, Okoshi Y, Suzukawa K, Yokoyama Y, Obara N, Sakata-Yanagimoto M, Noguchi M, Aoki M, Ando K, Chiba S.
- Organizer
  第72回日本血液学会総会
- Place of Presentation
  パシフィコ横浜(横浜)
- Year and Date
  2010-09-25
- Data Source
  KAKENHI-PROJECT-22390191
[Presentation] Dual antitumor mechanisms of Notch signaling inhibitor in axenograft model2008
- Author(s)
  千葉滋
- Organizer
  Notch and Cancer
- Place of Presentation
  ギリシャ、アテネ
- Year and Date
  2008-10-06
- Data Source
  KAKENHI-PROJECT-20015010
[Presentation] Notch signaling as a therapeutic target of cancer.2008
- Author(s)
  Mamiko Sakata-Yanagimoto, Shigeru Chiba, 他
- Organizer
  The 13th Japan-Korea Cancer Research Workshop.
- Place of Presentation
  韓国Daejeon
- Year and Date
  2008-12-13
- Data Source
  KAKENHI-PROJECT-19390258
[Presentation] Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma2007
- Author(s)
  Suk-young Lee, Shigeru Chiba, 他
- Organizer
  49th American Society of Hematology Annual Meeting
- Place of Presentation
  米国ジョージア州アトランタ
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19390258
[Presentation] Gain-of-Function Mutations and Copy Number Increases of Notch2 in Diffuse Large B-Cell Lymphoma2007
- Author(s)
  李碩瑛、千葉滋、他
- Organizer
  第49回米国血液学会
- Place of Presentation
  米国(アトランタ)
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-19390258
[Presentation] Gain-of-Function Mutations and Copy Number Increases of Notch2 in Diffuse Large B-Cell Lymphoma2007
- Author(s)
  李碩瑛、千葉滋, 他
- Organizer
  第49回米国血液学科年次総会
- Place of Presentation
  米国アトランタ
- Year and Date
  2007-12-10
- Data Source
  KAKENHI-PROJECT-18013012
[Presentation] 分子標的としてのNotchシグナル2007
- Author(s)
  千葉滋
- Organizer
  第69回日本血液学会・第49回日本臨床血液学合同総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-19390258
[Presentation] Essential role of Notch signaling in in vivo mucosal-type mast cell maturation and localization, and eradication of parasites2007
- Author(s)
  Mamiko Sakata-Yanagimoto, Shigeru Chiba, 他
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Year and Date
  2007-11-21
- Data Source
  KAKENHI-PROJECT-19390258
[Presentation] 分子標的としてのNotchシグナル2007
- Author(s)
  千葉滋
- Organizer
  第69回日本血液学会・第49回日本臨床血液学合同総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-12
- Data Source
  KAKENHI-PROJECT-18013012
[Presentation] Activating mutations and copy number gains of Notch2 in diffuse large B-cell lymphoma2007
- Author(s)
  Suk-young Lee, Shigeru Chiba, 他
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-19390258
[Presentation] Mutations in epigenetic and metabolic regulators in peripheral T-cell lymphoma
- Author(s)
  坂田（柳元）麻実子、千葉滋
- Organizer
  第76回　日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Invited
- Data Source
  KAKENHI-PROJECT-24390241
[Presentation] Somatic mosaic mutations in TET2 and DNMT3A in a case of peripheral T-cell lymphoma
- Author(s)
  Nguyen Bich Tran、千葉滋、他
- Organizer
  第76回　日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-25670444
[Presentation] Multistep tumorigenesis in peripheral T-cell lymphoma
- Author(s)
  坂田（柳元）麻実子、千葉滋
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PROJECT-24390241
[Presentation] Multistep tumorigenesis in peripheral T-cell lymphoma
- Author(s)
  坂田（柳元）麻実子、千葉滋
- Organizer
  第73回　日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112703
[Presentation] Mutations in epigenetic and metabolic regulators in peripheral T-cell lymphoma
- Author(s)
  坂田（柳元）麻実子、千葉滋
- Organizer
  第76回　日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112703
[Presentation] Genetic analysis of T-cell lymphoma developed in TET2 knockdown mice
- Author(s)
  武藤秀治、千葉滋、他
- Organizer
  第76回　日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-30 – 2014-11-02
- Data Source
  KAKENHI-PUBLICLY-25112703
[Presentation] Genetic analysis of T-cell lymphoma developed in TET2 knockdown mice
- Author(s)
  武藤秀治、千葉滋、他
- Organizer
  第76回　日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31 – 2014-11-02
- Data Source
  KAKENHI-PROJECT-24390241

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Chiba Shigeru 千葉 滋

CHIBA Shigeru 千葉 滋

Research Projects

Research Products

Co-Researchers

胚中心B細胞とリンパ球再循環に注目した濾胞性ヘルパーT細胞リンパ腫病態の解明Principal InvestigatorOngoing

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Mechanisms of tumor-supporting mechanisms in hematologic malinganciesOngoing

Principal Investigator

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Integrated approach toward angioimmunoblastic T-cell lymphoma - elucidation of molecular mechanism and development of diagnostics and therapeuticsPrincipal Investigator

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Clonal evolution of tumor-infiltrating cells in T-cell lymphomas

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エイジングに伴うエピゲノム変化に注目した造血幹細胞の前がん化機構Principal InvestigatorOngoing

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Unraveling bone marrow erythropoiesis nichePrincipal Investigator

Principal Investigator

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Elucidation of the pathological mechanism in refractory leukemia,

Principal Investigator

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悪性リンパ腫における腫瘍細胞と微小環境とのコミュニケーションPrincipal Investigator

Principal Investigator

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Origin of inflammatory cells constituting malignant lymphoma tissuePrincipal Investigator

Principal Investigator

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TET2 gene abnormality and epigenetic dysregulation in hematologic malignanciesPrincipal Investigator

Principal Investigator

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造血細胞運命決定においてＨｅｓ１の可逆的短時間発現変動が果たす役割Principal Investigator

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Establishment of evaluation method for double strand repair capacity with peripheral blood

Principal Investigator

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Pathophysiology of myelodyspoastic syndrome - network between bone marrow and nervus systemPrincipal Investigator

Principal Investigator

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Chiba Shigeru 千葉滋

CHIBA Shigeru 千葉滋