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Nishikii Hidekazu  錦井 秀和

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NISHIKII Hidekazu  錦井 秀和

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Researcher Number 30512834
Other IDs
Affiliation (Current) 2022: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help 2018 – 2022: 筑波大学, 医学医療系, 准教授
2015 – 2018: 筑波大学, 医学医療系, 助教
2011 – 2012: 筑波大学, 医学医療系, 講師
2010: 筑波大学, 大学院・人間総合科学研究科, 講師
2009: University of Tsukuba, 附属病院, 病院講師
2008: University of Tsukuba, 附属病院, レジデント
Review Section/Research Field
Principal Investigator
Hematology / Basic Section 54010:Hematology and medical oncology-related
Except Principal Investigator
Basic Section 54010:Hematology and medical oncology-related / Basic Section 52010:General internal medicine-related / Medium-sized Section 28:Nano/micro science and related fields
Keywords
Principal Investigator
造血幹細胞 / Notchシグナル / 移植片対宿主病 / 巨核球 / 造血幹細胞ニッチ / 造血幹細胞移植 / 血栓 / 止血学 / 分化運命 / Hes1 … More / レトロウイルス / センダイウイルス / トロンボポエチン / Notch / 骨髄移植 / 制御性T細胞 / TNFRSF25 / 急性骨髄性白血病 / 造血ニッチ / 造血器腫瘍 / 骨髄異形成症候群 / 骨髄繊維症 / 幹細胞ニッチ / 間葉系幹細胞 … More
Except Principal Investigator
がん微小環境 / T細胞リンパ腫 / TET2 / RHOA / T細胞リンパ腫 / 炎症細胞 / 微小環境 / 加齢性疾患 / 臓器老化 / 骨髄臓器連関 / 1細胞 / 電気泳動 / マイクロ流体工学 / RNA-sequencing Less
  • Research Projects

    (9 results)
  • Research Products

    (28 results)
  • Co-Researchers

    (20 People)
  •  ヒト造血幹細胞の不均一性の解明と機能制御Principal Investigator

    • Principal Investigator
      錦井 秀和
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      University of Tsukuba
  •  革新技術を駆使し骨髄臓器連関からアプローチする加齢性疾患発症と臓器老化機構の解明

    • Principal Investigator
      臼井 丈一
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      University of Tsukuba
  •  ナノ電気穿孔を用いた1細胞ダイナミクス計測法の創成

    • Principal Investigator
      新宅 博文
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 28:Nano/micro science and related fields
    • Research Institution
      Institute of Physical and Chemical Research
  •  Mechanisms of tumor-supporting mechanisms in hematologic malingancies

    • Principal Investigator
      Sakata-Yanagimoto Mamiko
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      University of Tsukuba
  •  Analyses of hematopoietic niche in hematologic malignancyPrincipal Investigator

    • Principal Investigator
      Nishikii Hidekazu
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54010:Hematology and medical oncology-related
    • Research Institution
      University of Tsukuba
  •  Analyses of immune tolerance mechanism in allogeneic transplantationPrincipal Investigator

    • Principal Investigator
      Nishikii Hidekazu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      University of Tsukuba
  •  巨核球・血小板分化における転写因子HES1が担う制御機構の解明Principal Investigator

    • Principal Investigator
      錦井 秀和
    • Project Period (FY)
      2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      University of Tsukuba
  •  The role of Notch signaling in megakaryocytopoiesisPrincipal Investigator

    • Principal Investigator
      NISHIKII Hidekazu
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Hematology
    • Research Institution
      University of Tsukuba
  •  The immunoregulation of Notch signaling in graft versus host disease.Principal Investigator

    • Principal Investigator
      NISHIKII Hidekazu
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (Start-up)
    • Research Field
      Hematology
    • Research Institution
      University of Tsukuba

All 2020 2019 2017 2016 2015 Other

All Journal Article Presentation

  • [Journal Article] 18 FDG-PET imaging and histopathology in neuroleukemiosis with acute myeloid leukemia.2020

    • Author(s)
      Kiyoki Yusuke、Matsuoka Ryota、Kaneta Tomohiro、Nishikii Hidekazu
    • Journal Title

      International journal of hematology

      Volume: 112 Pages: 433-433

    • DOI

      10.1007/s12185-020-02976-w

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K16165, KAKENHI-PROJECT-18K08316
  • [Journal Article] Durable Leukemic Remission and Autologous Marrow Recovery with Random Chromosomal Abnormalities after Allogeneic Hematopoietic Stem Cell Transplantation for Chronic Lymphocytic Leukemia.2019

    • Author(s)
      Nishikii Hidekazu、Kurita Naoki、Shinagawa Atsushi、Sakamoto Tatsuhiro、Kusakabe Manabu、Yokoyama Yasuhisa、Kato Takayasu、Sakata-Yanagimoto Mamiko、Obara Naoshi、Hasegawa Yuichi、Nakamura Naoya、Chiba Shigeru
    • Journal Title

      Case Report in Hematology

      Volume: 2019 Pages: 1-5

    • DOI

      10.1155/2019/9710790

    • NAID

      120007128070

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-18K08316, KAKENHI-PROJECT-18K16076, KAKENHI-PROJECT-18K16107, KAKENHI-PROJECT-17K09946
  • [Journal Article] Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis.2019

    • Author(s)
      Cao-Sy Luan、Obara Naoshi、Sakamoto Tatsuhiro、Kato Takayasu、Hattori Keiichiro、Sakashita Shingo、Nannya Yasuhito、Ogawa Seishi、Harada Hironori、Sakata-Yanagimoto Mamiko、Nishikii Hidekazu、Chiba Shigeru
    • Journal Title

      Int J Hematol

      Volume: 109 Pages: 309-318

    • DOI

      10.1007/s12185-018-02576-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-18K16107, KAKENHI-PROJECT-26221308, KAKENHI-PROJECT-16K09831, KAKENHI-PROJECT-18K08316, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-19H05656
  • [Journal Article] Notch signaling in Nestin-expressing cells in the bone marrow maintains erythropoiesis via macrophage integrity.2019

    • Author(s)
      Sakamoto Tatsuhiro、Obara Naoshi、Nishikii Hidekazu、Kato Takayasu、Luan Cao Sy、Fujimura Ryosuke、Yagita Hideo、Sakata-Yanagimoto Mamiko、Takahashi Satoru、Chiba Shigeru
    • Journal Title

      Stem cells

      Volume: 印刷中 Pages: 924-936

    • DOI

      10.1002/stem.3011

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-18K08316, KAKENHI-PROJECT-18K16107, KAKENHI-PROJECT-17K09915
  • [Journal Article] Successful management of primary immune thrombocytopenia with romiplostim during open heart surgery in a hemodialysis patient2019

    • Author(s)
      錦井 秀和、栗田 尚樹、日下部 学、横山 泰久、加藤 貴康、坂田(柳元) 麻実子、小原 直、長谷川 雄一、千葉 滋
    • Journal Title

      Jpn. J. Clin. Hematol.

      Volume: 60 Issue: 1 Pages: 28-28

    • DOI

      10.11406/rinketsu.60.28

    • NAID

      130007590727

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-18K08316, KAKENHI-PROJECT-18K16076
  • [Journal Article] A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.2017

    • Author(s)
      Ronald JA, Kim BS, Gowrishankar G, Namavari M, Alam IS, D'Souza, Nishikii H, Chuang HY, Ilovich O, Lin CF, Reeves R, Shuhendler A, Hoehne A, Chan CT, Baker J, Yaghoubi SS, VanBrocklin HF, Hawkins R, Franc BL, Jivan S, Slater JB, Verdin EF, Gao KT, Benjamin J, Negrin R, Gambhir SS.
    • Journal Title

      Cancer Research

      Volume: 77(11) Pages: 2893-2902

    • DOI

      10.1158/0008-5472.can-16-2953

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis.2017

    • Author(s)
      Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS.
    • Journal Title

      Nature Communications.

      Volume: 8 Pages: 15068-15068

    • DOI

      10.1038/ncomms15068

    • NAID

      120007129109

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells.2017

    • Author(s)
      Nishikii H, Kurita N, Chiba S.
    • Journal Title

      Stem Cells Translational Medicine

      Volume: 6(8) Pages: 1661-1665

    • DOI

      10.1002/sctm.16-0490

    • NAID

      120007128846

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Haploidentical transplantation using post-transplant high-dose cyclophosphamide for adult T-cell lymphoma after mogamulizumab treatment2017

    • Author(s)
      日下部 学、栗田 尚樹、錦井 秀和ら
    • Journal Title

      Jpn. J. Clin. Hematol.

      Volume: 58 Issue: 5 Pages: 449-454

    • DOI

      10.11406/rinketsu.58.449

    • NAID

      130005690164

    • ISSN
      0485-1439, 1882-0824
    • Language
      Japanese
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-15K09493
  • [Journal Article] DR3 signaling modulates the function of Foxp+ regulatory T cells and the severity of acute graft-versus host disease2016

    • Author(s)
      Nishikii H, KIm BS, Negrin RS
    • Journal Title

      Blood

      Volume: 128 Pages: 2846-2858

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Exogenous TNFR2 activation protests from acute GVHD via host Treg cell expansion.2016

    • Author(s)
      Chopra M Biehi M, Nishikii H (21番目), Beilhack A
    • Journal Title

      Journal of Experimental Medicine

      Volume: 213 Pages: 1881-1900

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] TNF-a priming enhances CD4+Foxp3+regulatory T cell suppressive function in murine GVHD preservation and treatment.2016

    • Author(s)
      Pierini A, Strober W, Nishikii H (5番目), Negrin RS
    • Journal Title

      Blood

      Volume: 128 Pages: 866-871

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Donor requierements for regulatory T cell suppression of murine graft-versus-host disease.2015

    • Author(s)
      3.Pierini A, Colonna L, Alvarez M, Schneidawind D, Nishikii H, BakerJ, Pan Y, Florek M, Kim BS, Negrin RS
    • Journal Title

      Journal of Immunology

      Volume: 195 Pages: 347-355

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Engraftment of Embryonic Stem Cells and Differentiated Progeny by Host Conditioning with Total Lymphoid Irradiation and Regulatory T Cells.2015

    • Author(s)
      Pan Y, Leverson-Gower DB, De Almeida PE, Pierini A, Baker J, Florek M, Nishikii H, Kim BS, Ke R, Wu JC, Negrin RS
    • Journal Title

      Cell Reports

      Volume: 10 Pages: 1793-1802

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Regulatory T cell Immunotherapy in Immune-Mediated Disease.2015

    • Author(s)
      Pierini A, Schneidawind D, Nishikii H (Co first), Negrin RS.
    • Journal Title

      Current Stem Cell Report

      Volume: 1 Pages: 177-186

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Journal Article] Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease.2015

    • Author(s)
      Kim BS, Nishikii H(Co first), Baker J, Pierini A, Schneidawind D, Pan Y, Beilhack A, Park CG, Negrin RS
    • Journal Title

      Blood

      Volume: 126 Pages: 546-557

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Leukemic proliferation-stress induces the defecto of stem cell niche and normal hematopoiesis.2020

    • Author(s)
      斎藤美月、田中紗貴、錦井秀和 清木祐介、坂本竜弘、加藤貴康、坂田(柳元)麻実子、千葉滋
    • Organizer
      第82回日本血液学会学術集会
    • Data Source
      KAKENHI-PROJECT-18K08316
  • [Presentation] Distinct Schwann cell abnormalities in MDS and MPN bone marrow with fibrosis2019

    • Author(s)
      Luan Cao-Sy, Yoshiaki Takahoko, Naoshi Obara, Tatsuhiro Sakamoto, Takayasu Kato, Keiichiro Hattori, Ryota Matsuoka, Shingo Sakashita, Yasuhito Nannya, Hideki Makishima, Seishi Ogawa, Mamiko Sakata-Yanagimoto, Hidekazu Nishikii, Shigeru Chiba
    • Organizer
      日本血液学会総会
    • Data Source
      KAKENHI-PROJECT-18K08316
  • [Presentation] Distinct bone marrow microenvironment abnormalities in MDS and MPN with fibrosis2019

    • Author(s)
      Luan Cao-Sy, Yoshiaki Takahoko, Naoshi Obara, Tatsuhiro Sakamoto, Takayasu Kato, Keiichiro Hattori, Ryota Matsuoka, Shingo Sakashita, Yasuhito Nannya, Hideki Makishima, Seishi Ogawa, Mamiko Sakata-Yanagimoto, Hidekazu Nishikii, Shigeru Chiba
    • Organizer
      Annual Meeting of American Society of Hematology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K08316
  • [Presentation] Foxp3陽性制御性T細胞は骨髄移植後のB細胞分化に必要な造血環境を維持している2017

    • Author(s)
      錦井 秀和
    • Organizer
      日本造血細胞移植学会総会
    • Place of Presentation
      島根県松江市
    • Year and Date
      2017-03-02
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Foxp3+ 陽性制御性T細胞は骨髄移植後のB細胞分化に必要な造血環境を維持している2017

    • Author(s)
      錦井秀和、Pierini Antonio, 横山 泰久, 木村 隆治, Hye-Sook Kwon, Maite Alvarez, Judith A Shizuru, Joy Y Wu, 千葉 滋, Robert S. Negrin.
    • Organizer
      日本造血細胞移植学会
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation From Hematopoietic Stem Cells.2016

    • Author(s)
      Nishikii Hidekazu
    • Organizer
      Hematopoietic Stem Cell Researchers symposium
    • Place of Presentation
      東京都港区 東京大学医科学研究所
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation From Hematopoietic Stem Cells.2016

    • Author(s)
      Nishikii Hidekazu
    • Organizer
      アメリカ血液学会
    • Place of Presentation
      サンディエゴ 米国
    • Year and Date
      2016-12-03
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation。2016

    • Author(s)
      錦井 秀和
    • Organizer
      日本血液学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation From Hematopoietic Stem Cells.2016

    • Author(s)
      Nishikii Hidekazu
    • Organizer
      JSH国際シンポジウム
    • Place of Presentation
      兵庫県淡路島
    • Year and Date
      2016-05-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Expanded CD4+Foxp3+ regulatory T cells through DR3 signaling showed distinct immunophenotype and prevented the lethal acute-graft and host disease after allogeneic transplantation.2015

    • Author(s)
      Hidekazu Nishikii, Byung Su Kim, Antonio Pierini, Jeanette Baker, Yasuhisa Yokoyama, Dominik Schneidawind, Yuqiong Pan, Maite Alvarez, Yan Chen, Shigeru Chiba, Robert S. Negrin
    • Organizer
      ASH annual meeting 2015
    • Place of Presentation
      米国 オーランド
    • Year and Date
      2015-12-05
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09493
  • [Presentation] Implication of distinct differentiation pathway of megakaryocytes from hematopoietic stem cells in the mouse bone marrow.

    • Author(s)
      Hidekazu Nishikii
    • Organizer
      American Society of Hematology Annual Meeting
    • Place of Presentation
      Georgia World Congress Center(Atlanta, 米国)
    • Data Source
      KAKENHI-PROJECT-24790959
  • [Presentation] Identification of monolineage megakaryocyte progenitor through a previously unidentified differentiation pathway.

    • Author(s)
      錦井 秀和
    • Organizer
      第10回幹細胞シンポジウム
    • Place of Presentation
      淡路島夢舞台国際会議場(兵庫県)
    • Data Source
      KAKENHI-PROJECT-24790959
  • 1.  Sakata-Yanagimoto Mamiko (80451805)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  千葉 滋 (60212049)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  加藤 貴康 (20646591)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 7 results
  • 4.  日下部 学 (40804381)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  小原 直 (70422178)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 6 results
  • 6.  横山 泰久 (70512820)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 7.  臼井 丈一 (70447340)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  山崎 聡 (50625580)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  新宅 博文 (80448050)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  口丸 高弘 (10570591)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  塩見 晃史 (60880557)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  金子 泰洸ポール (80873504)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  鳥井 孝太郎 (80878463)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  KURITA Naoki
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 15.  Sato Aiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  HARADA Yuka
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  NANYA Yasuhito
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  坂本 竜弘
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 19.  小川 誠司
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  原田 浩徳
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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