Nishikii Hidekazu 錦井秀和

… Alternative Names

Researcher Number	30512834
Affiliation (Current)	2019: 筑波大学, 医学医療系, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 筑波大学, 医学医療系, 准教授 2015 – 2018: 筑波大学, 医学医療系, 助教 2011 – 2012: 筑波大学, 医学医療系, 講師 2010: 筑波大学, 大学院・人間総合科学研究科, 講師 2009: University of Tsukuba, 附属病院, 病院講師 2008: University of Tsukuba, 附属病院, レジデント
Review Section/Research Field	Principal Investigator Hematology / Basic Section 54010:Hematology and medical oncology-related Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related
Keywords	Principal Investigator 巨核球 / 造血幹細胞 / 移植片対宿主病 / Notchシグナル / 骨髄移植 / レトロウイルス / 制御性T細胞 / 造血器腫瘍 / 造血幹細胞移植 / トロンボポエチン … More Except Principal Investigator Ｔ細胞リンパ腫 / TET2 / T細胞リンパ腫 / RHOA / 微小環境 / 炎症細胞 Less

Mechanisms of tumor-supporting mechanisms in hematologic malinganciesOngoing
- Principal Investigator
  
  坂田麻実子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Tsukuba
造血器腫瘍における造血ニッチ細胞の遺伝子・機能異常解析Principal InvestigatorOngoing
- Principal Investigator
  
  錦井秀和
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  University of Tsukuba
Analyses of immune tolerance mechanism in allogeneic transplantationPrincipal Investigator
- Principal Investigator
  
  Nishikii Hidekazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
巨核球・血小板分化における転写因子ＨＥＳ１が担う制御機構の解明Principal Investigator
- Principal Investigator
  
  錦井秀和
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
The role of Notch signaling in megakaryocytopoiesisPrincipal Investigator
- Principal Investigator
  
  NISHIKII Hidekazu
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba
The immunoregulation of Notch signaling in graft versus host disease.Principal Investigator
- Principal Investigator
  
  NISHIKII Hidekazu
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Hematology
- Research Institution
  University of Tsukuba

All 2017 2016 2015 Other

All Journal Article Presentation

[Journal Article] A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.2017
- Author(s)
  Ronald JA, Kim BS, Gowrishankar G, Namavari M, Alam IS, D'Souza, Nishikii H, Chuang HY, Ilovich O, Lin CF, Reeves R, Shuhendler A, Hoehne A, Chan CT, Baker J, Yaghoubi SS, VanBrocklin HF, Hawkins R, Franc BL, Jivan S, Slater JB, Verdin EF, Gao KT, Benjamin J, Negrin R, Gambhir SS.
- Journal Title
  
  Cancer Research
  
  Volume: 77(11) Pages: 2893-2902
- DOI
  10.1158/0008-5472.can-16-2953
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis.2017
- Author(s)
  Pierini A, Nishikii H, Baker J, Kimura T, Kwon HS, Pan Y, Chen Y, Alvarez M, Strober W, Velardi A, Shizuru JA, Wu JY, Chiba S, Negrin RS.
- Journal Title
  
  Nature Communications.
  
  Volume: 8 Pages: 15068-15068
- DOI
  10.1038/ncomms15068
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Haploidentical transplantation using post-transplant high-dose cyclophosphamide for adult T-cell lymphoma after mogamulizumab treatment2017
- Author(s)
  日下部　学、栗田　尚樹、錦井　秀和ら
- Journal Title
  
  Rinsho Ketsueki.
  
  Volume: 58 Issue: 5 Pages: 449-454
- DOI
  10.11406/rinketsu.58.449
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09898, KAKENHI-PROJECT-15K09493
[Journal Article] The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells.2017
- Author(s)
  Nishikii H, Kurita N, Chiba S.
- Journal Title
  
  Stem Cells Translational Medicine
  
  Volume: 6(8) Pages: 1661-1665
- DOI
  10.1002/sctm.16-0490
- Open Access / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] DR3 signaling modulates the function of Foxp+ regulatory T cells and the severity of acute graft-versus host disease2016
- Author(s)
  Nishikii H, KIm BS, Negrin RS
- Journal Title
  
  Blood
  
  Volume: 128 Pages: 2846-2858
- Acknowledgement Compliant / Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Exogenous TNFR2 activation protests from acute GVHD via host Treg cell expansion.2016
- Author(s)
  Chopra M Biehi M, Nishikii H (21番目), Beilhack A
- Journal Title
  
  Journal of Experimental Medicine
  
  Volume: 213 Pages: 1881-1900
- Acknowledgement Compliant / Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] TNF-a priming enhances CD4+Foxp3+regulatory T cell suppressive function in murine GVHD preservation and treatment.2016
- Author(s)
  Pierini A, Strober W, Nishikii H (５番目), Negrin RS
- Journal Title
  
  Blood
  
  Volume: 128 Pages: 866-871
- Acknowledgement Compliant / Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Regulatory T cell Immunotherapy in Immune-Mediated Disease.2015
- Author(s)
  Pierini A, Schneidawind D, Nishikii H (Co first), Negrin RS.
- Journal Title
  
  Current Stem Cell Report
  
  Volume: 1 Pages: 177-186
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Donor requierements for regulatory T cell suppression of murine graft-versus-host disease.2015
- Author(s)
  3.Pierini A, Colonna L, Alvarez M, Schneidawind D, Nishikii H, BakerJ, Pan Y, Florek M, Kim BS, Negrin RS
- Journal Title
  
  Journal of Immunology
  
  Volume: 195 Pages: 347-355
- Open Access / Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Engraftment of Embryonic Stem Cells and Differentiated Progeny by Host Conditioning with Total Lymphoid Irradiation and Regulatory T Cells.2015
- Author(s)
  Pan Y, Leverson-Gower DB, De Almeida PE, Pierini A, Baker J, Florek M, Nishikii H, Kim BS, Ke R, Wu JC, Negrin RS
- Journal Title
  
  Cell Reports
  
  Volume: 10 Pages: 1793-1802
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Journal Article] Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease.2015
- Author(s)
  Kim BS, Nishikii H(Co first), Baker J, Pierini A, Schneidawind D, Pan Y, Beilhack A, Park CG, Negrin RS
- Journal Title
  
  Blood
  
  Volume: 126 Pages: 546-557
- Int'l Joint Research / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Foxp3陽性制御性T細胞は骨髄移植後のB細胞分化に必要な造血環境を維持している2017
- Author(s)
  錦井　秀和
- Organizer
  日本造血細胞移植学会総会
- Place of Presentation
  島根県松江市
- Year and Date
  2017-03-02
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Foxp3+ 陽性制御性T細胞は骨髄移植後のB細胞分化に必要な造血環境を維持している2017
- Author(s)
  錦井秀和、Pierini Antonio, 横山　泰久, 木村　隆治, Hye-Sook Kwon, Maite Alvarez, Judith A Shizuru, Joy Y Wu, 千葉　滋, Robert S. Negrin.
- Organizer
  日本造血細胞移植学会
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation。2016
- Author(s)
  錦井　秀和
- Organizer
  日本血液学会総会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation From Hematopoietic Stem Cells.2016
- Author(s)
  Nishikii Hidekazu
- Organizer
  アメリカ血液学会
- Place of Presentation
  サンディエゴ　米国
- Year and Date
  2016-12-03
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation From Hematopoietic Stem Cells.2016
- Author(s)
  Nishikii Hidekazu
- Organizer
  Hematopoietic Stem Cell Researchers symposium
- Place of Presentation
  東京都港区　東京大学医科学研究所
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Foxp3+ Regulatory T Cells Maintain Bone Marrow Microenvironment for B Cell Differentiation From Hematopoietic Stem Cells.2016
- Author(s)
  Nishikii Hidekazu
- Organizer
  JSH国際シンポジウム
- Place of Presentation
  兵庫県淡路島
- Year and Date
  2016-05-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Expanded CD4+Foxp3+ regulatory T cells through DR3 signaling showed distinct immunophenotype and prevented the lethal acute-graft and host disease after allogeneic transplantation.2015
- Author(s)
  Hidekazu Nishikii, Byung Su Kim, Antonio Pierini, Jeanette Baker, Yasuhisa Yokoyama, Dominik Schneidawind, Yuqiong Pan, Maite Alvarez, Yan Chen, Shigeru Chiba, Robert S. Negrin
- Organizer
  ASH annual meeting 2015
- Place of Presentation
  米国オーランド
- Year and Date
  2015-12-05
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K09493
[Presentation] Implication of distinct differentiation pathway of megakaryocytes from hematopoietic stem cells in the mouse bone marrow.
- Author(s)
  Hidekazu Nishikii
- Organizer
  American Society of Hematology Annual Meeting
- Place of Presentation
  Georgia World Congress Center（Atlanta, 米国）
- Data Source
  KAKENHI-PROJECT-24790959
[Presentation] Identification of monolineage megakaryocyte progenitor through a previously unidentified differentiation pathway.
- Author(s)
  錦井　秀和
- Organizer
  第10回幹細胞シンポジウム
- Place of Presentation
  淡路島夢舞台国際会議場（兵庫県）
- Data Source
  KAKENHI-PROJECT-24790959

1. 坂田麻実子 (80451805)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
2. 千葉滋 (60212049)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 加藤貴康 (20646591)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 日下部学 (40804381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 小原直 (70422178)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 横山泰久 (70512820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nishikii Hidekazu 錦井 秀和

NISHIKII Hidekazu 錦井 秀和

Research Projects

Research Products

Co-Researchers

Mechanisms of tumor-supporting mechanisms in hematologic malinganciesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

造血器腫瘍における造血ニッチ細胞の遺伝子・機能異常解析Principal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analyses of immune tolerance mechanism in allogeneic transplantationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

巨核球・血小板分化における転写因子ＨＥＳ１が担う制御機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of Notch signaling in megakaryocytopoiesisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The immunoregulation of Notch signaling in graft versus host disease.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] A PET Imaging Strategy to Visualize Activated T Cells in Acute Graft-versus-Host Disease Elicited by Allogenic Hematopoietic Cell Transplant.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Foxp3+ regulatory T cells maintain the bone marrow microenvironment for B cell lymphopoiesis.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Haploidentical transplantation using post-transplant high-dose cyclophosphamide for adult T-cell lymphoma after mogamulizumab treatment2017

Author(s)

Journal Title

DOI

Language

Data Source

[Journal Article] The Road Map for Megakaryopoietic Lineage from Hematopoietic Stem/Progenitor Cells.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] DR3 signaling modulates the function of Foxp+ regulatory T cells and the severity of acute graft-versus host disease2016

Author(s)

Journal Title

Data Source

[Journal Article] Exogenous TNFR2 activation protests from acute GVHD via host Treg cell expansion.2016

Author(s)

Journal Title

Data Source

[Journal Article] TNF-a priming enhances CD4+Foxp3+regulatory T cell suppressive function in murine GVHD preservation and treatment.2016

Author(s)

Journal Title

Data Source

[Journal Article] Regulatory T cell Immunotherapy in Immune-Mediated Disease.2015

Author(s)

Journal Title

Data Source

[Journal Article] Donor requierements for regulatory T cell suppression of murine graft-versus-host disease.2015

Author(s)

Nishikii Hidekazu 錦井秀和

NISHIKII Hidekazu 錦井秀和