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USHIO Yukitaka
生塩 之敬
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Alternative Names
生塩 之敬 ウシオ ユキタカ
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Researcher Number
20028583
External Links
Affiliation (based on the past Project Information)
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1988 – 2002: 熊本大学, 医学部, 教授
1986: 阪大, 医学部, 助手
Review Section/Research Field
Principal Investigator
Cerebral neurosurgery
/
Biological Sciences
Except Principal Investigator
Cerebral neurosurgery
Keywords
Principal Investigator
グリオーマ / MCP-1 / 脳腫瘍 / PDGF / 増殖因子 / malignant glioma / ケモカイン / Glioma / chemokine / 遺伝子治療
…
More
/ 電気遺伝子療法 / IL-12 / サイトカイン / 生体内電気穿孔法 / glioma / growth factor / therapy / dissemination / Growth Factor / Chemotherapy / NF1 / NF2 / monocyte / MCP-1 receptor / gene therapy / drug delivery / chemotherapy / 抗癌剤 / gene analysis / p53 / p16 / EGFR / prognosis / classification / fractalkine / cloning / neurocytoma / ganglioglioma / medulloblastoma / フラクタルカイン / クローニング / 浸潤 / 接着分子 / EST / ライブラリースクリーニング / HS-tk / combination electro-gene therapy / 自殺遺伝子 / TATペプチド融合蛋白 / TAT-lacZ / TAT-p16 / 髄腔内播種 / 悪性脳腫瘍 / C6グリオーマ細胞 / TAT-GFP / 電気穿孔法 / Hsv-tk / DT-A / 臨床応用 / Trapidil / Dissemination / Fluocytometry / トラピジ-ル / スラミン / グリオーマ細胞 / Neurofibromatosis / 遺伝子 / 細胞内情報伝達 / GLIOMA / TRAPIGIL / SURAMIN / プラスミドDNA / lacZ遺伝子 / human MCP-1遺伝子 / MCP-1遺伝子 / hMCP1 / electro-genetherapy (EGT) / in vivo electroporation / brain tumor / lac Z gene / plasmid DNA / CCR2 / 単球 / リンパ球 / 転写因子 / プロモーター / マクロファージ / MCP-1レセプター / 免疫 / 遺伝子療法 / invasin / マイクロスフィアー / GST融合蛋白 / Invasin / microsphere / anti-cancer drug / GST-fusion protein / LOH10 / glioblastoma / 10番染色体 / LOH / PTEN / 生存日数 / 機能的解析 / LOH 10 / LAK細胞 / 養子免疫療法 / インターロイキシー2 / Lymphokine-activated killer(LAK)細胞 / インターロイキン-2 / ガンマ・インターフェロン / モデル / Brain neoplasms / Lymphokine-activated Killer (LAK) cells / Adoptive immunotherapy / 癌化学療法 / 薬剤耐性 / 制癌剤 / インターフェロン / Drug-resistant
…
More
Except Principal Investigator
Striatum / MCP-1 / basal ganglia / substantia nigra / グリオーマ / promoter / transplantation / Basal ganglia / IL-12 / 自殺遺伝子 / 悪性脳腫瘍 / neuronal death / cerebral ischemia / plasticity / マクロファージ / プロモーター / Transplantation / 免疫組織化学 / 遺伝子治療 / 電気遺伝子療法 / 悪性グリオーマ / 髄腔内播種 / 線条体 / 黒質 / monocyte / CCR2 / Oct-1 / C / EBP / gene regulation / glioma / ケモカイン / Cerebral ischemia / N-methyl-D-aspartate / GABA / STEP / 脳虚血 / Globus pallidus / Parkinson's disease / Movement disorders / Monkey / Therapy / monkey / electro-gene therapy / suicide gene / NF2 / gene / cloning / luciferase / methylation / malignant glioma / Reelin / reeler / cerebral cortex / dopaminergic neurons / Cajal-Retzius cells / development / 海馬 / リン酸化反応 / 燐酸化反応 / HIPPOCAMPUS / PHOSPHORYLATION / CREB / Akt / striatum / substntia nigra / MCP-1受容体 / 発現調節機構 / Cerebral Ischemia / Plasticity / 塞栓術 / 粒子塞栓物質 / マイクロキャリーア / 脳動脈瘤 / in situ hybridization / コラゲン / 血管平滑筋 / HS-tk / combination electro-gene therapy / サイトカイン / 生体内電気穿孔法 / 髄腔内化学療法 / ニトロソウレア / リボソーム / BCNU / リポソーム / 髄液腔内潅流療法 / 神経膠腫(グリオーマ) / 髄腔内潅流化学療法 / ACNU / MALIGNANT GLIOMAS / SUBARACHNOID DISSEMINATION / INTRATHECAL CHEMOTHERAPY / NITROSOUREAS / LIPOSOME / 一過性局所脳虚血 / 選択的神経細胞死 / MRI / 脳浮腫 / 血管透過性 / 神経移植 / カルレチニン / 燐酸化チロシン / ミクログリア / 移植 / 再生 / カルシウム結合蛋白 / 一過性虚所脳虚血 / 脳血管透過性 / アポモルフィン / カルシニューリン / TRANSIENT CEREBRAL ISCHEMIA / STRIATUM / SUBSTANTIA NIGRA / MAGNETIC RESONANCE IMAGING / APOMORPHINE / MICROGLIA / IMMUNOHISTOCHEMISTRY / TRANSPLANTATION / 単球 / 受容体 / Ca^<2+>-signal / STFP / Phoaphatase / NMDA receptor / GABA agonist / Second messenger / Tyrosine dephosphorylation / Neuronal development / 神経細胞死 / 細胞内情報伝達 / カルシウム / Calcium signal / Tyrosine-phosphatase / Deep brain stimulation / Basal Ganglia / Movement Disorders / Deep brain Stimulation / gene therapy / chemokine gene / CT26 tumor / アポトーシス / 放射線化学療法感受性 / apoptosis / radio-chemosensitivity / subarachnoid dissemination / 電気穿孔法 / 脳腫瘍 / 臨床応用 / 脳腫瘍モデル / 安全性 / brain tumor / clinical application / ドーパミン / reeler mutant / 細胞遊走 / 軸索形成 / 脳形成 / タウ因子 / 一過性脳虚血 / ISCHEMIA / TAR FACTOR / NEURONAL CELL DEATH / 脳虚血耐性 / CRE-decoy / ISCHEMIC TOLERANCE
Less
Research Projects
(
31
results)
Co-Researchers
(
20
People)
Project Start Year (Newest)
Project Start Year (Oldest)
生体内電気穿孔法を用いた電気遺伝子療法の臨床応用へ向けた安全性に関する研究
Principal Investigator
Principal Investigator
生塩 之敬
Project Period (FY)
2001
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section
Biological Sciences
Research Institution
Kumamoto University
Research for clinical application of electro-gene therapy against malignant brain tumor
Principal Investigator
KOCHI Masato
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Reformation of the dopaminergic nigrostriatal pathway: a role of reeler gene product Reelin
Principal Investigator
GOTO Satoshi
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
The role of phosphorylation reaction of tau factor in ischemic neuronal cell death
Principal Investigator
MORIOKA Motohiro
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Research for the mechanism of ischemic tolerance in neuronal cells
Principal Investigator
YANO Shigetoshi
Project Period (FY)
2001 – 2002
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
固形癌に対する自殺遺伝子とサイトカイン遺伝子群を併用した複合電気遺伝子療法の開発
Principal Investigator
Principal Investigator
生塩 之敬
Project Period (FY)
2000
Research Category
Grant-in-Aid for Scientific Research on Priority Areas (C)
Review Section
Biological Sciences
Research Institution
Kumamoto University
悪性脳腫瘍の自殺遺伝子・複数サイトカイン遺伝子を用いた複合電気遺伝子療法の開発
Principal Investigator
西 徹
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
シッピシグ・タグ付加レコンビナント蛋白質の髄液内投与と悪性脳腫瘍治療への応用
Principal Investigator
Principal Investigator
生塩 之敬
Project Period (FY)
2000
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Research for pathophysiology of subarachnoid dissemination of malignant brain tumors
Principal Investigator
KOCHI Masato
Project Period (FY)
2000 – 2001
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
CLASSIFICATION OF MALIGNANT GLIOMAS BY MOLECULAR GENETIC ANALYSIS TO DEVELOP RATIONAL THERAPY
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1999 – 2001
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
Role of NF2 tumor suppressor gene promoter in the tumorigenesis
Principal Investigator
TAKESHIMA Hideo
Project Period (FY)
1999 – 2000
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kagoshima University
Kumamoto University
脳腫瘍における模型ケモカインのクローニングと解析
Principal Investigator
Principal Investigator
生塩 之敬
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Development of globus pallidus externus stimulation for Parkinson's disease
Principal Investigator
GOTO Satoshi
Project Period (FY)
1998 – 2000
Research Category
Grant-in-Aid for Scientific Research (B).
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Development of a method for combination electro-gene therapy using suicide gene and chemokine gene(s)
Principal Investigator
NISHI Toru
Project Period (FY)
1998 – 1999
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
Developement of a method for cancer treatment using invsin-conjugated microsphere
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
Development of the Gene-missile therapy against human malignant gliomas using monocyte as a carrier.
Principal Investigator
TAKESHIMA Hideo
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Study on the ischemia-induced neuronal injuries with special reference to alterations in the intracellular signaling cascades.
Principal Investigator
GOTO Satoshi
Project Period (FY)
1997 – 1998
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
単球遊走因子受容体の発現調節機構の解明と脳腫瘍治療への応用
Principal Investigator
TAKESHIMA Hideo
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
線条体障害ラットにおける大脳基底核神経回路網の再構築移植治療に関する実験的研究
Principal Investigator
後藤 恵
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
新しい粒子塞栓物質の基礎的研究と臨床応用
Principal Investigator
HAMADA Junichiro
Project Period (FY)
1996
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
脳動脈瘤の増大、破裂機序:細胞外マトリックスの変動に関する研究
Principal Investigator
永廣 信治
Project Period (FY)
1996
Research Category
Grant-in-Aid for Exploratory Research
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
New approach for the treatment of glioblastomas.
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1996 – 1998
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
線条体内神経細胞移殖による大脳基底核神経回路網の再構築:虚血性線条体障害ラットを用いた実験的研究
Principal Investigator
後藤 恵
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
DEVELOPMENT OF GENE TRANSFER METHOD FOR SOLID TUMORS USING IN VIVO ELECTROPORATION.
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1995 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
虚血性大脳基底核障害:動物モデルを用いた病態解折、移植治療に関する実験的研究
Principal Investigator
GOTO Satoshi
Project Period (FY)
1994
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Establishment of the New Approach to the Treatment of Malignant Glioma
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1994 – 1995
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
INTRATHECAL CHEMOTHERAPY AGAINST SUBARACHNOID DISSEMINATION OF MALIGNANT BRAIN TUMORS
Principal Investigator
HAMADA Junichiro
,
河内 正人
Project Period (FY)
1993 – 1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
PATHOPHYSIOLOGY AND TREATMENT OF STRIATONIGRAL ISCHEMIC INJURY
Principal Investigator
NAGAHIRO Shinjl
Project Period (FY)
1993 – 1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY MEDICAL SCHOOL
A Study for New Approaches in the Treatment of Malignant Gliomas.
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Cerebral neurosurgery
Research Institution
KUMAMOTO UNIVERSITY
Molecular Cell Biology of Drug-resistant Glioma and Treatment.
Principal Investigator
Principal Investigator
USHIO Yukitaka
Project Period (FY)
1988 – 1990
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Cerebral neurosurgery
Research Institution
Kumamoto University
Cooperative effects between chemotherapy and adoptive immunotherapy for brain tumors
Principal Investigator
Principal Investigator
YOSHIMINE Toshiki
, 生塩 之敬
Project Period (FY)
1986 – 1987
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Cerebral neurosurgery
Research Institution
Osaka University
# of Projects (Dsc)
# of Projects (Asc)
1.
NISHI Tohru
(00264309)
# of Collaborated Projects:
17 results
# of Collaborated Products:
0 results
2.
KOCHI Masato
(70178218)
# of Collaborated Projects:
17 results
# of Collaborated Products:
0 results
3.
GOTO Satoshi
(50240916)
# of Collaborated Projects:
11 results
# of Collaborated Products:
0 results
4.
NAGAHIRO Shinji
(60145315)
# of Collaborated Projects:
10 results
# of Collaborated Products:
0 results
5.
KURATSU Jun-ichi
(20145296)
# of Collaborated Projects:
10 results
# of Collaborated Products:
0 results
6.
TAKESHIMA Hideo
(70244134)
# of Collaborated Projects:
10 results
# of Collaborated Products:
0 results
7.
HAMADA Junichiro
(40253752)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
8.
SAYA Hideyuki
(80264282)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
9.
MORIOKA Motohiro
(20295140)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
10.
SETO Hiroshi
(60209848)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
11.
TAKADA Akira
(10187966)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
UEMURA Shozaburo
(00128258)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
YANO Shigetoshi
(60332871)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
NAKANO Masahiro
(40002125)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
15.
SAITO Yoshiki
(50304994)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
16.
YOSHIMINE Toshiki
(00201046)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
17.
SHIMIZU Keiji
(50162699)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
三浦 正毅
(00192352)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
SUGIMOTO Yoshikazu
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
SAKATA Tsuneaki
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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