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USHIO Yukitaka  生塩 之敬

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… Alternative Names

生塩 之敬  ウシオ ユキタカ

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Researcher Number 20028583
External Links
Affiliation (based on the past Project Information) *help 1988 – 2002: 熊本大学, 医学部, 教授
1986: 阪大, 医学部, 助手
Review Section/Research Field
Principal Investigator
Cerebral neurosurgery / Biological Sciences
Except Principal Investigator
Cerebral neurosurgery
Keywords
Principal Investigator
グリオーマ / MCP-1 / 脳腫瘍 / PDGF / 増殖因子 / malignant glioma / ケモカイン / Glioma / chemokine / 遺伝子治療 … More / 電気遺伝子療法 / IL-12 / サイトカイン / 生体内電気穿孔法 / glioma / growth factor / therapy / dissemination / Growth Factor / Chemotherapy / NF1 / NF2 / monocyte / MCP-1 receptor / gene therapy / drug delivery / chemotherapy / 抗癌剤 / gene analysis / p53 / p16 / EGFR / prognosis / classification / fractalkine / cloning / neurocytoma / ganglioglioma / medulloblastoma / フラクタルカイン / クローニング / 浸潤 / 接着分子 / EST / ライブラリースクリーニング / HS-tk / combination electro-gene therapy / 自殺遺伝子 / TATペプチド融合蛋白 / TAT-lacZ / TAT-p16 / 髄腔内播種 / 悪性脳腫瘍 / C6グリオーマ細胞 / TAT-GFP / 電気穿孔法 / Hsv-tk / DT-A / 臨床応用 / Trapidil / Dissemination / Fluocytometry / トラピジ-ル / スラミン / グリオーマ細胞 / Neurofibromatosis / 遺伝子 / 細胞内情報伝達 / GLIOMA / TRAPIGIL / SURAMIN / プラスミドDNA / lacZ遺伝子 / human MCP-1遺伝子 / MCP-1遺伝子 / hMCP1 / electro-genetherapy (EGT) / in vivo electroporation / brain tumor / lac Z gene / plasmid DNA / CCR2 / 単球 / リンパ球 / 転写因子 / プロモーター / マクロファージ / MCP-1レセプター / 免疫 / 遺伝子療法 / invasin / マイクロスフィアー / GST融合蛋白 / Invasin / microsphere / anti-cancer drug / GST-fusion protein / LOH10 / glioblastoma / 10番染色体 / LOH / PTEN / 生存日数 / 機能的解析 / LOH 10 / LAK細胞 / 養子免疫療法 / インターロイキシー2 / Lymphokine-activated killer(LAK)細胞 / インターロイキン-2 / ガンマ・インターフェロン / モデル / Brain neoplasms / Lymphokine-activated Killer (LAK) cells / Adoptive immunotherapy / 癌化学療法 / 薬剤耐性 / 制癌剤 / インターフェロン / Drug-resistant … More
Except Principal Investigator
Striatum / MCP-1 / basal ganglia / substantia nigra / グリオーマ / promoter / transplantation / Basal ganglia / IL-12 / 自殺遺伝子 / 悪性脳腫瘍 / neuronal death / cerebral ischemia / plasticity / マクロファージ / プロモーター / Transplantation / 免疫組織化学 / 遺伝子治療 / 電気遺伝子療法 / 悪性グリオーマ / 髄腔内播種 / 線条体 / 黒質 / monocyte / CCR2 / Oct-1 / C / EBP / gene regulation / glioma / ケモカイン / Cerebral ischemia / N-methyl-D-aspartate / GABA / STEP / 脳虚血 / Globus pallidus / Parkinson's disease / Movement disorders / Monkey / Therapy / monkey / electro-gene therapy / suicide gene / NF2 / gene / cloning / luciferase / methylation / malignant glioma / Reelin / reeler / cerebral cortex / dopaminergic neurons / Cajal-Retzius cells / development / 海馬 / リン酸化反応 / 燐酸化反応 / HIPPOCAMPUS / PHOSPHORYLATION / CREB / Akt / striatum / substntia nigra / MCP-1受容体 / 発現調節機構 / Cerebral Ischemia / Plasticity / 塞栓術 / 粒子塞栓物質 / マイクロキャリーア / 脳動脈瘤 / in situ hybridization / コラゲン / 血管平滑筋 / HS-tk / combination electro-gene therapy / サイトカイン / 生体内電気穿孔法 / 髄腔内化学療法 / ニトロソウレア / リボソーム / BCNU / リポソーム / 髄液腔内潅流療法 / 神経膠腫(グリオーマ) / 髄腔内潅流化学療法 / ACNU / MALIGNANT GLIOMAS / SUBARACHNOID DISSEMINATION / INTRATHECAL CHEMOTHERAPY / NITROSOUREAS / LIPOSOME / 一過性局所脳虚血 / 選択的神経細胞死 / MRI / 脳浮腫 / 血管透過性 / 神経移植 / カルレチニン / 燐酸化チロシン / ミクログリア / 移植 / 再生 / カルシウム結合蛋白 / 一過性虚所脳虚血 / 脳血管透過性 / アポモルフィン / カルシニューリン / TRANSIENT CEREBRAL ISCHEMIA / STRIATUM / SUBSTANTIA NIGRA / MAGNETIC RESONANCE IMAGING / APOMORPHINE / MICROGLIA / IMMUNOHISTOCHEMISTRY / TRANSPLANTATION / 単球 / 受容体 / Ca^<2+>-signal / STFP / Phoaphatase / NMDA receptor / GABA agonist / Second messenger / Tyrosine dephosphorylation / Neuronal development / 神経細胞死 / 細胞内情報伝達 / カルシウム / Calcium signal / Tyrosine-phosphatase / Deep brain stimulation / Basal Ganglia / Movement Disorders / Deep brain Stimulation / gene therapy / chemokine gene / CT26 tumor / アポトーシス / 放射線化学療法感受性 / apoptosis / radio-chemosensitivity / subarachnoid dissemination / 電気穿孔法 / 脳腫瘍 / 臨床応用 / 脳腫瘍モデル / 安全性 / brain tumor / clinical application / ドーパミン / reeler mutant / 細胞遊走 / 軸索形成 / 脳形成 / タウ因子 / 一過性脳虚血 / ISCHEMIA / TAR FACTOR / NEURONAL CELL DEATH / 脳虚血耐性 / CRE-decoy / ISCHEMIC TOLERANCE Less
  • Research Projects

    (31 results)
  • Co-Researchers

    (20 People)
  •  生体内電気穿孔法を用いた電気遺伝子療法の臨床応用へ向けた安全性に関する研究Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  Research for clinical application of electro-gene therapy against malignant brain tumor

    • Principal Investigator
      KOCHI Masato
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Reformation of the dopaminergic nigrostriatal pathway: a role of reeler gene product Reelin

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  The role of phosphorylation reaction of tau factor in ischemic neuronal cell death

    • Principal Investigator
      MORIOKA Motohiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Research for the mechanism of ischemic tolerance in neuronal cells

    • Principal Investigator
      YANO Shigetoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  固形癌に対する自殺遺伝子とサイトカイン遺伝子群を併用した複合電気遺伝子療法の開発Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kumamoto University
  •  悪性脳腫瘍の自殺遺伝子・複数サイトカイン遺伝子を用いた複合電気遺伝子療法の開発

    • Principal Investigator
      西 徹
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  シッピシグ・タグ付加レコンビナント蛋白質の髄液内投与と悪性脳腫瘍治療への応用Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Research for pathophysiology of subarachnoid dissemination of malignant brain tumors

    • Principal Investigator
      KOCHI Masato
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  CLASSIFICATION OF MALIGNANT GLIOMAS BY MOLECULAR GENETIC ANALYSIS TO DEVELOP RATIONAL THERAPYPrincipal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Role of NF2 tumor suppressor gene promoter in the tumorigenesis

    • Principal Investigator
      TAKESHIMA Hideo
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kagoshima University
      Kumamoto University
  •  脳腫瘍における模型ケモカインのクローニングと解析Principal Investigator

    • Principal Investigator
      生塩 之敬
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Development of globus pallidus externus stimulation for Parkinson's disease

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Development of a method for combination electro-gene therapy using suicide gene and chemokine gene(s)

    • Principal Investigator
      NISHI Toru
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Developement of a method for cancer treatment using invsin-conjugated microspherePrincipal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Development of the Gene-missile therapy against human malignant gliomas using monocyte as a carrier.

    • Principal Investigator
      TAKESHIMA Hideo
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Study on the ischemia-induced neuronal injuries with special reference to alterations in the intracellular signaling cascades.

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  単球遊走因子受容体の発現調節機構の解明と脳腫瘍治療への応用

    • Principal Investigator
      TAKESHIMA Hideo
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  線条体障害ラットにおける大脳基底核神経回路網の再構築移植治療に関する実験的研究

    • Principal Investigator
      後藤 恵
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  新しい粒子塞栓物質の基礎的研究と臨床応用

    • Principal Investigator
      HAMADA Junichiro
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  脳動脈瘤の増大、破裂機序:細胞外マトリックスの変動に関する研究

    • Principal Investigator
      永廣 信治
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  New approach for the treatment of glioblastomas.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  線条体内神経細胞移殖による大脳基底核神経回路網の再構築:虚血性線条体障害ラットを用いた実験的研究

    • Principal Investigator
      後藤 恵
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  DEVELOPMENT OF GENE TRANSFER METHOD FOR SOLID TUMORS USING IN VIVO ELECTROPORATION.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  虚血性大脳基底核障害:動物モデルを用いた病態解折、移植治療に関する実験的研究

    • Principal Investigator
      GOTO Satoshi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Establishment of the New Approach to the Treatment of Malignant GliomaPrincipal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  INTRATHECAL CHEMOTHERAPY AGAINST SUBARACHNOID DISSEMINATION OF MALIGNANT BRAIN TUMORS

    • Principal Investigator
      HAMADA Junichiro, 河内 正人
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  PATHOPHYSIOLOGY AND TREATMENT OF STRIATONIGRAL ISCHEMIC INJURY

    • Principal Investigator
      NAGAHIRO Shinjl
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY MEDICAL SCHOOL
  •  A Study for New Approaches in the Treatment of Malignant Gliomas.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      KUMAMOTO UNIVERSITY
  •  Molecular Cell Biology of Drug-resistant Glioma and Treatment.Principal Investigator

    • Principal Investigator
      USHIO Yukitaka
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Kumamoto University
  •  Cooperative effects between chemotherapy and adoptive immunotherapy for brain tumorsPrincipal Investigator

    • Principal Investigator
      YOSHIMINE Toshiki, 生塩 之敬
    • Project Period (FY)
      1986 – 1987
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Osaka University
  • 1.  NISHI Tohru (00264309)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 2.  KOCHI Masato (70178218)
    # of Collaborated Projects: 17 results
    # of Collaborated Products: 0 results
  • 3.  GOTO Satoshi (50240916)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 4.  NAGAHIRO Shinji (60145315)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 5.  KURATSU Jun-ichi (20145296)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 6.  TAKESHIMA Hideo (70244134)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 0 results
  • 7.  HAMADA Junichiro (40253752)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 8.  SAYA Hideyuki (80264282)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  MORIOKA Motohiro (20295140)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 10.  SETO Hiroshi (60209848)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  TAKADA Akira (10187966)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  UEMURA Shozaburo (00128258)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  YANO Shigetoshi (60332871)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  NAKANO Masahiro (40002125)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SAITO Yoshiki (50304994)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  YOSHIMINE Toshiki (00201046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  SHIMIZU Keiji (50162699)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  三浦 正毅 (00192352)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  SUGIMOTO Yoshikazu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SAKATA Tsuneaki
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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