Kanekura Kohsuke 金蔵孝介

… Alternative Names

金倉孝介カネクラコウスケ

KANEKURA Kohsuke 金蔵孝介

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Researcher Number	10508568
Other IDs
Affiliation (Current)	2025: 東京医科大学, 医学部, 主任教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京医科大学, 医学部, 主任教授 2021 – 2023: 東京医科大学, 医学部, 准教授 2016 – 2020: 東京医科大学, 医学部, 講師 2008 – 2009: Keio University, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 47040:Pharmacology-related / Basic Section 52020:Neurology-related / Neurology / Pathological medical chemistry Except Principal Investigator Basic Section 56010:Neurosurgery-related / Medium-sized Section 28:Nano/micro science and related fields / Basic Section 56060:Ophthalmology-related / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 28030:Nanomaterials-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Veterinary medical science
Keywords	Principal Investigator ALS / C9ORF72 / 液液相分離 / 筋萎縮性側索硬化症 / C9orf72 / プロテオーム解析 / 相転移 / LLPS / 非膜性オルガネラ / TDP-43 … More / 脳神経疾患 / プロテオミクス / ER stress / VAPB / UPR … More Except Principal Investigator 脳脊髄腫瘍 / 術中蛍光造影 / インドシアニングリーン / グラフェン / 液液相分離 / バイオセンサ / ニコチナミドモノヌクレオチド / 環境 / 角膜移植 / 角膜内皮細胞 / 虹彩萎縮 / 前房関連角膜内皮症 / 治療薬 / 細胞老化 / 前房環境 / 難治性水疱性角膜症 / メタボローム / ATP産生 / mtDNA / 代謝 / ES細胞 / ミトコンドリア / 初期化 / 核置換 / 胚性ゲノム活性化 / iPS細胞 / テロメア / ZGA / ゲノム安定性 / 多能性幹細胞 / ホウ素中性子捕捉療法 / RI創薬 / EPR効果 / 近赤外線 / 腫瘍蛍光 / 転移性脳腫瘍 / ドラックデリバリーシステム / 蛍光ナビゲーション / ドラッグデリバリーシステム / 抗がん薬 / メンブレンレスオルガネラ / 増強ラマン散乱 / 単一分子エンドスコピー / エンドスコピー / ナノプロドラッグ / 細胞内相分離 / membrane-less organelle / 単一細胞エンドスコピー / 単一細胞解析 / ラマン分光 / 薬輸送システム / 信号伝達 / ナノ界面 / ナノ材料 / 自己組織化ペプチド / 2次元ナノ材料 / ナノシート / 自己組織化 / ペプチド / 生体材料 / 機能解析 / 構造解析 / 相分離 / 遺伝性疾患 / 液相分離 / 単一遺伝子疾患 / 先天性疾患 / MIRAGE症候群 / SAMD9 / ポリA鎖 / 上皮悪性腫瘍 / 低分子化合物スクリーニング / CPEB1 / ポリアデニル化複合体 / 乳がん / 低分子化合物 / 転写後調節 / 乳癌 Less

C9ORF72変異ALSにおける非膜性オルガネラ機能障害機構の解明Principal Investigator
- Principal Investigator
  
  金蔵孝介
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 47040:Pharmacology-related
- Research Institution
  Tokyo Medical University
Development of a Novel Treatment Method Using Boron Radioisotope Compounds Targeting Brain and Spinal Cord Tumors
- Principal Investigator
  
  武藤淳
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Fujita Health University
液液相分離における分子間相互作用を検出するナノ材料計測基盤
- Principal Investigator
  
  早水裕平
- Project Period (FY)
  2024 – 2025
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Tokyo Institute of Technology
Establishment of experimental basis to improve the prognosis of corneal transplantation in treating bullous keratoplasty due to pathological aqueous humor.
- Principal Investigator
  
  山口剛史
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56060:Ophthalmology-related
- Research Institution
  Tokyo Dental College
Knowledge-driven Nanodrug design through understanding of a role of Phase-separated condensate in chemotherapy using Single-Cell endoscopy
- Principal Investigator
  
  雲林院宏
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 28:Nano/micro science and related fields
- Research Institution
  Hokkaido University
Establishment of Intraoperative Fluorescence Diagnosis and Development of Therapeutic Techniques for Brain and Spinal Tumors Using Indocyanine Green
- Principal Investigator
  
  Muto Jun
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Fujita Health University
Understanding of signal transduction via peptides at the interface of cells and nanomaterials
- Principal Investigator
  
  Hayamizu Yuhei
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 28030:Nanomaterials-related
- Research Institution
  Tokyo Institute of Technology
Functional-structural relationship of liquid-liquid phase separation caused by ALS-causing proteins and its pathological significance.Principal Investigator
- Principal Investigator
  
  Kanekura Kohsuke
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52020:Neurology-related
- Research Institution
  Tokyo Medical University
全能性獲得へのロードマップ：幹細胞のミトコンドリア・ゲノム安定性機構の解明
- Principal Investigator
  
  山田満稔
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Keio University
Functional, structural and pathological analysis of SAMD9/SAMD9L, liquid-liquid phase separation-related molecules
- Principal Investigator
  
  Satoshi Narumi
- Project Period (FY)
  2019 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Child Health and Development
Investigation of inhibitor molecules focusing on cytoplasmic polyadenylation complex in epithelial malignant tumor
- Principal Investigator
  
  NAGAOKA KENTARO
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Veterinary medical science
- Research Institution
  Tokyo University of Agriculture and Technology
Establishment of ALS treatment strategy using Multi-omics technologyPrincipal Investigator
- Principal Investigator
  
  Kanekura Kohsuke
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Tokyo Medical University
Functional analysis of the novel ALS-causative VAPB gene.Principal Investigator
- Principal Investigator
  
  KANEKURA Kohsuke
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (Start-up)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016 2009 2008

All Journal Article Presentation

[Journal Article] How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?2022
- Author(s)
  Kanekura Kohsuke、Kuroda Masahiko
- Journal Title
  
  Laboratory Investigation
  
  Volume: 102 Issue: 9 Pages: 912-918
- DOI
  10.1038/s41374-022-00791-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-21H04634
[Journal Article] The Patterning and Proportion of Charged Residues in the Arginine-Rich Mixed-Charge Domain Determine the Membrane-Less Organelle Targeted by the Protein2022
- Author(s)
  Miyagi Tamami、Yamazaki Rio、Ueda Koji、Narumi Satoshi、Hayamizu Yuhei、Uji-i Hiroshi、Kuroda Masahiko、Kanekura Kohsuke
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 14 Pages: 7658-7658
- DOI
  10.3390/ijms23147658
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H04634
[Journal Article] Effect of Multivalency on Phase-Separated Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA at the Solid/Liquid Interface2022
- Author(s)
  Chen Chen、Jia Han、Nakamura Yoshiki、Kanekura Kohsuke、Hayamizu Yuhei
- Journal Title
  
  ACS Omega
  
  Volume: 7 Issue: 23 Pages: 19280-19287
- DOI
  10.1021/acsomega.2c00811
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H04634
[Journal Article] Order controls disordered droplets: structure-function relationships in C9ORF72-derived poly(PR)2022
- Author(s)
  Kanekura Kohsuke、Hayamizu Yuhei、Kuroda Masahiko
- Journal Title
  
  American Journal of Physiology-Cell Physiology
  
  Volume: 322 Issue: 2 Pages: C197-C204
- DOI
  10.1152/ajpcell.00372.2021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706
[Journal Article] Nuclear microRNAs release paused Pol II via the DDX21-CDK9 complex2022
- Author(s)
  Shin-Ichiro Ohno, Keiki Oikawa, Toshiaki Tsurui, Yuichirou Harada, Kana Ono, Mizumo Tateishi, Aashiq Mirza, Masakatsu Takanashi, Kosuke Kanekura, Kumiko Nagase, Yoshihisa Shimada, Yujin Kudo, Norihiko Ikeda, Takahiro Ochiya, Xiaozhong Wang , Masahiko Kuroda
- Journal Title
  
  Cell Reports
  
  Volume: 12;39(2) Issue: 2 Pages: 110673-110673
- DOI
  10.1016/j.celrep.2022.110673
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K06953, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706
[Journal Article] Chemically oligomerizable TDP-43: a novel chemogenetic tool for studying the pathophysiology of amyotrophic lateral sclerosis2022
- Author(s)
  Kanekura Kohsuke、Yamanaka Yoshiaki、Miyagi Tamami、Kuroda Masahiko
- Journal Title
  
  Neural Regeneration Research
  
  Volume: 17 Issue: 11 Pages: 2434-2434
- DOI
  10.4103/1673-5374.335803
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-21H04634
[Journal Article] Acerola exosome-like nanovesicles to systemically deliver nucleic acid medicine via oral administration.2021
- Author(s)
  Umezu T, Takanashi M, Murakami Y, Ohno SI, Kanekura K, Sudo K, Nagamine K, Takeuchi S, Ochiya T, Kuroda M.
- Journal Title
  
  Molecular therapy. Methods & clinical development.
  
  Volume: 10;21 Pages: 199-208
- DOI
  10.1016/j.omtm.2021.03.006
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08382, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706
[Journal Article] Establishment of chemically oligomerizable TAR DNA-binding protein-43 which mimics amyotrophic lateral sclerosis pathology in mammalian cells2021
- Author(s)
  Yamanaka Yoshiaki、Miyagi Tamami、Harada Yuichiro、Kuroda Masahiko、Kanekura Kohsuke
- Journal Title
  
  Laboratory Investigation
  
  Volume: 101 Issue: 10 Pages: 1331-1340
- DOI
  10.1038/s41374-021-00623-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706
[Journal Article] Phase separation and toxicity of C9orf72 poly(PR) depends on alternate distribution of arginine.2021
- Author(s)
  Chen C, Yamanaka Y, Ueda K, Li P, Miyagi T, Harada Y, Tezuka S, Narumi S, Sugimoto M, Kuroda M, Hayamizu Y, Kanekura K.
- Journal Title
  
  J Cell Biol.
  
  Volume: 220 Issue: 11
- DOI
  10.1083/jcb.202103160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03627, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706, KAKENHI-PLANNED-20H05743
[Journal Article] An improved macromolecular crowding sensor CRONOS for detection of crowding changes in membrane-less organelles under stressed conditions.2021
- Author(s)
  Miyagi T, Yamanaka Y, Harada Y, Narumi S, Hayamizu Y, Kuroda M, Kanekura K.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 583 Pages: 29-34
- DOI
  10.1016/j.bbrc.2021.10.055
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03627, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706
[Journal Article] Diffusion of LLPS Droplets Consisting of Poly(PR) Dipeptide Repeats and RNA on Chemically Modified Glass Surface2021
- Author(s)
  Chen Chen、Li Peiying、Luo Wei、Nakamura Yoshiki、Dimo Vanessa Seudo、Kanekura Kohsuke、Hayamizu Yuhei
- Journal Title
  
  Langmuir
  
  Volume: 37 Issue: 18 Pages: 5635-5641
- DOI
  10.1021/acs.langmuir.1c00493
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H03593
[Journal Article] Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma.2021
- Author(s)
  Jigjidkhorloo N, Kanekura K, Matsubayashi J, Akahane D, Fujita K, Oikawa K, Kurata A, Takanashi M, Endou H, Nagao T, Gotoh A, Norov O, Kuroda M.
- Journal Title
  
  Sci Rep.
  
  Volume: 11(1) Issue: 1 Pages: 21638-21638
- DOI
  10.1038/s41598-021-00811-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08382, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-21H02706, KAKENHI-PROJECT-20K07398, KAKENHI-PROJECT-20K07417
[Journal Article] Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice2020
- Author(s)
  Yamaguchi Takefumi、Higa Kazunari、Yagi-Yaguchi Yukari、Ueda Koji、Noma Hisashi、Shibata Shinsuke、Nagai Toshihiro、Tomida Daisuke、Yasu-Mimura Ririko、Ibrahim Osama、Matoba Ryo、Tsubota Kazuo、Hamrah Pedram、Yamada Jun、Kanekura Kohsuke、Shimazaki Jun
- Journal Title
  
  Science Advances
  
  Volume: 6 Issue: 20 Pages: 5195-5195
- DOI
  10.1126/sciadv.aaz5195
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16KT0116, KAKENHI-PROJECT-20K21663, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-18K14840
[Journal Article] A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome2020
- Author(s)
  Mahadevan Jana、Morikawa Shuntaro、Yagi Takuya、Abreu Damien、Lu Simin、Kanekura Kohsuke、Brown Cris M.、Urano Fumihiko
- Journal Title
  
  Laboratory Investigation
  
  Volume: 100 Issue: 9 Pages: 1197-1207
- DOI
  10.1038/s41374-020-0436-1
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03593
[Journal Article] miR-27a ameliorates chemoresistance of breast cancer cells by disruption of reactive oxygen species homeostasis and impairment of autophagy2020
- Author(s)
  Ueda S, Takanashi M, Sudo K, Kanekura K, Kuroda M
- Journal Title
  
  Lab Invest.
  
  Volume: - Issue: 6 Pages: 863-873
- DOI
  10.1038/s41374-020-0409-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08382, KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-16H06247, KAKENHI-PROJECT-17K10564, KAKENHI-PROJECT-20K08943, KAKENHI-PROJECT-20H03593
[Journal Article] Poor outcomes in carriers of the RNF213 variant (p.Arg4810Lys) with pulmonary arterial hypertension2020
- Author(s)
  Hiraide Takahiro、Kataoka Masaharu、Suzuki Hisato、Aimi Yuki、Chiba Tomohiro、Isobe Sarasa、Katsumata Yoshinori、Goto Shinichi、Kanekura Kohsuke et al.,
- Journal Title
  
  The Journal of Heart and Lung Transplantation
  
  Volume: 39 Issue: 2 Pages: 103-112
- DOI
  10.1016/j.healun.2019.08.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H06247, KAKENHI-PROJECT-17K15782, KAKENHI-PROJECT-16H05304, KAKENHI-PROJECT-15H05665, KAKENHI-PROJECT-18K08154
[Journal Article] Neuroplastin Modulates Anti-inflammatory Effects of MANF2020
- Author(s)
  Yagi Takuya、Asada Rie、Kanekura Kohsuke、Eesmaa Ave、Lindahl Maria、Saarma Mart、Urano Fumihiko
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 12 Pages: 101810-101810
- DOI
  10.1016/j.isci.2020.101810
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H03593
[Journal Article] Comprehensive analysis of liver and blood miRNA in precancerous conditions2020
- Author(s)
  Umezu Tomohiro、Tsuneyama Koichi、Kanekura Kohsuke、Hayakawa Michiyo、Tanahashi Toshihito、Kawano Mitsuoki、Taguchi Y-h、Toyoda Hidenori、Tamori Akihiro、Kuroda Masahiko、Murakami Yoshiki
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 21766-21766
- DOI
  10.1038/s41598-020-78500-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K12067, KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-18K07069, KAKENHI-PROJECT-18K07244, KAKENHI-PUBLICLY-19H05270, KAKENHI-PUBLICLY-20H04848
[Journal Article] A Novel Homozygous Mutation of Thyroid Peroxidase Gene Abolishes a Disulfide Bond Leading to Congenital Hypothyroidism2020
- Author(s)
  Yakou Fumiyoshi、Suwanai Hirotsugu、Ishikawa Takuya、Itou Mariko、Shikuma Jumpei、Miwa Takashi、Sakai Hiroyuki、Kanekura Kohsuke、Narumi Satoshi、Suzuki Ryo、Odawara Masato
- Journal Title
  
  International Journal of Endocrinology
  
  Volume: 2020 Pages: 1-8
- DOI
  10.1155/2020/9132372
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03593, KAKENHI-PROJECT-19K22607
[Journal Article] Therapeutic potential of PLK1 inhibition in triple-negative breast cancer2019
- Author(s)
  Ueda Ai, Oikawa Keiki, Fujita Koji, Ishikawa Akio, Sato Eiichi, Ishikawa Takashi, Kuroda Masahiko, Kanekura Kohsuke
- Journal Title
  
  Laboratory Investigation
  
  Volume: 99 Issue: 9 Pages: 1275-1286
- DOI
  10.1038/s41374-019-0247-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H04067, KAKENHI-PROJECT-19H03729, KAKENHI-PROJECT-16H06247
[Journal Article] SOX17 Mutations in Japanese Patients with Pulmonary Arterial Hypertension2018
- Author(s)
  Hiraide Takahiro、Kataoka Masaharu、Suzuki Hisato、Aimi Yuki、Chiba Tomohiro、Kanekura Kohsuke、Satoh Toru、Fukuda Keiichi、Gamou Shinobu、Kosaki Kenjiro
- Journal Title
  
  American Journal of Respiratory and Critical Care Medicine
  
  Volume: 198 Issue: 9 Pages: 1231-1233
- DOI
  10.1164/rccm.201804-0766le
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08154, KAKENHI-PROJECT-17K15782, KAKENHI-PROJECT-16H05303, KAKENHI-PROJECT-16H06247, KAKENHI-PROJECT-15H05665
[Journal Article] Characterization of membrane penetration and cytotoxicity of C9orf72-encoding arginine-rich dipeptides.2018
- Author(s)
  Kanekura K, Harada Y, Fujimoto M, Yagi T, Hayamizu Y, Nagaoka K, Kuroda M
- Journal Title
  
  Sci Rep
  
  Volume: 8 Issue: 1 Pages: 12740-12740
- DOI
  10.1038/s41598-018-31096-z
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03923, KAKENHI-PROJECT-16H06247
[Journal Article] Genomic Comparison With Supercentenarians Identifies RNF213 as a Risk Gene for Pulmonary Arterial Hypertension2018
- Author(s)
  Suzuki Hisato、Kataoka Masaharu、Hiraide Takahiro、Aimi Yuki、Yamada Yoshitake、Katsumata Yoshinori、Chiba Tomohiro、Kanekura Kohsuke、Isobe Sarasa、Sato Yasunori、Satoh Toru、Gamou Shinobu、Fukuda Keiichi、Kosaki Kenjiro
- Journal Title
  
  Circulation: Genomic and Precision Medicine
  
  Volume: 11 Issue: 12
- DOI
  10.1161/circgen.118.002317
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08154, KAKENHI-PROJECT-17K15782, KAKENHI-PROJECT-16H05303, KAKENHI-PROJECT-16H06247, KAKENHI-PROJECT-15H05665
[Journal Article] Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death2017
- Author(s)
  Clark AL, Kanekura K, Lavagnino Z, Spears LD, Abreu D, Mahadevan J, Yagi T, Semenkovich CF, Ppiston DW, Urano F
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 5611-5611
- DOI
  10.1038/s41598-017-05935-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06247
[Journal Article] Poly-dipeptides encoded by the C9ORF72 repeats block global protein translation.2016
- Author(s)
  Kanekura K, Yagi T, Carmack AJ, Mahadevan J, Kuroda M, Harms MB, Miller TM, Urano F
- Journal Title
  
  Human Molecular Genetics
  
  Volume: 25 Issue: 9 Pages: 1803-1813
- DOI
  10.1093/hmg/ddw052
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06247
[Journal Article] MicroRNA and gynecologic cancers.2016
- Author(s)
  Kanekura K, Nishi H, Isaka K, Kuroda M.
- Journal Title
  
  J Obstet Gynaecol Res.
  
  Volume: 10.1111/jog.12995 Issue: 6 Pages: 052-052
- DOI
  10.1111/jog.12995
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K15100, KAKENHI-PROJECT-26293088, KAKENHI-PROJECT-16H06247, KAKENHI-PROJECT-26461961
[Journal Article] Abnormal expression of TIP30 and arrested nucleocytoplasmic transport within oligodendrocyte precursor cells in multiple sclerosis.2009
- Author(s)
  Nakahara J, Kanekura K, et al.
- Journal Title
  
  Journal of Clinical Invesitigation 119
  
  Pages: 169-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890216
[Journal Article] ER Stress and Unfolded Protein Response in Amyotrophic Lateral Sclerosis.2009
- Author(s)
  Kanekura K, Suzuki H, Aiso S, Matsuoka M.
- Journal Title
  
  Molecular Neurobiology 39
  
  Pages: 81-89
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890216
[Journal Article] ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB.2009
- Author(s)
  Suzuki H†, Kanekura K†, et al. († : equally contributed)
- Journal Title
  
  Journal of Neurochemistry 108
  
  Pages: 973-985
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20890216
[Presentation] 筋萎縮性側索硬化症(ALS)原因ジペプチドリピートの細胞内局在および毒性メカニズムの解明.2023
- Author(s)
  宮城碧水、金蔵孝介
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] Alternating Arg distribution controls phase separation and toxicity of poly(PR).2022
- Author(s)
  金蔵孝介
- Organizer
  Neuro2022
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] Order controls disordered droplets: structure-function relationships in C9ORF72-derived poly(PR).2022
- Author(s)
  Kohsuke Kanekura
- Organizer
  2nd International research conference on neurodegenerative diseases (IRCND 2022).
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H04634
[Presentation] Alternating Arg distribution controls phase separation and toxicity of poly(PR)2022
- Author(s)
  金蔵孝介
- Organizer
  Neuro2022
- Invited
- Data Source
  KAKENHI-PROJECT-21H04634
[Presentation] 表面増強ラマン分光法を用いたペプチドーRNAの相分離液滴の計測2022
- Author(s)
  山崎唯衣、藤原將行、加藤遼、金蔵孝介、矢野隆章、早水裕平
- Organizer
  応用物理学会秋季学術講演会
- Data Source
  KAKENHI-PROJECT-20H02564
[Presentation] 筋萎縮性側索硬化症(ALS)原因ジペプチドリピートの細胞内局在および毒性メカニズムの解明2022
- Author(s)
  宮城碧水、金蔵孝介
- Organizer
  第147回日本薬理学会関東部会
- Data Source
  KAKENHI-PROJECT-21H04634
[Presentation] アミノ酸の性質から紐解くALS原因ジペプチドリピートの相分離と毒性機構2022
- Author(s)
  金蔵孝介
- Organizer
  第16回日本アミノ酸学会
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] アミノ酸の性質から紐解くALS原因ジペプチドリピートの相分離と毒性機構2022
- Author(s)
  金蔵孝介
- Organizer
  日本アミノ酸学会第16回学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21H04634
[Presentation] Alternating Arg distribution controls phase separation and toxicity of poly(PR).2021
- Author(s)
  金蔵孝介
- Organizer
  第44回日本分子生物学会
- Invited
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] The alternating structure controls phase separation and toxicity of poly-PR C9orf72 dipeptides.2020
- Author(s)
  金蔵孝介
- Organizer
  日本生化学会
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] AGE-DEPENDENT CHARACTERISTICS OF TRANSCRIPTION AND METABOLISM IN PLURIPOTENT STEM CELLS2020
- Author(s)
  Reina Ooka, Mitsutoshi Yamada*, Akihiro Nakamura, Tohru Sugawara, Kohsuke Kanekura, Kenji Miyado, Hidenori Akutsu, Mamoru Tanaka, and Akihiro Umezawa (*correspondence to)
- Organizer
  ISSCR Annual meeting 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K20330
[Presentation] C9orf72遺伝子産物poly-PRの構造機能連関と毒性獲得機構の解明2020
- Author(s)
  金蔵孝介
- Organizer
  日本認知症学会
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] Molecular interactions of poly(PR) dipeptides in liquid liquid phase separation.2020
- Author(s)
  Chen Chen, Kohsuke Kanekura, Yuhei Hayamizu
- Organizer
  応用物理学会
- Data Source
  KAKENHI-PROJECT-20H03593
[Presentation] デバイスに期待する医学2019
- Author(s)
  金蔵孝介
- Organizer
  第80回応用物理学会秋季学術講演会
- Invited
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] Molecular mechanisms underlying Neurodegenerative disorders: From Braak to exosome and cell-breadboard in future2019
- Author(s)
  Kohsuke Kanekura
- Organizer
  The second international workshop by the 174th committee JSPS on Symbiosis of Biology and Nanodevices
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] Molecular mechanisms underlying Neurodegenerative disorders2019
- Author(s)
  Kohsuke Kanekura
- Organizer
  The second international workshop by the 174th committee JSPS on Symbiosis of Biology and Nanodevices
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] ALS/FTD原因遺伝子C9orf72のRAN翻訳産物poly-PRによる神経細胞死機構の解析2019
- Author(s)
  金蔵孝介、Chen Chen、山中喜晃、早水裕平、黒田雅彦
- Organizer
  第38回本認知症学会学術集会
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] ALS 原因遺伝子C9orf72 遺伝子産物によるProteostasis 破綻機構の解明2019
- Author(s)
  金蔵孝介
- Organizer
  第92回日本生化学会
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] トリプルネガティブ乳癌におけるPLK1阻害の治療的有用性2019
- Author(s)
  上田亜衣,金蔵孝介, 黒田雅彦, 石川孝
- Organizer
  第27回日本乳癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] 細胞質ポリアデニル化複合体発現調節を介した乳がん抑制因子の探索2019
- Author(s)
  石井由里子、Sovijit Warcharee、金蔵孝介、渡辺元、永岡謙太郎
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-17H03923
[Presentation] プロテオミクスによる神経変性疾患研究2017
- Author(s)
  金蔵孝介
- Organizer
  第13回日本臨床プロテオーム研究会
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] オミクス技術を駆使した希少疾患研究2017
- Author(s)
  金蔵孝介
- Organizer
  Re-PCR 2017
- Invited
- Data Source
  KAKENHI-PROJECT-16H06247
[Presentation] The two faces of ALS-linked VAPB : the P56S mutation results in "loss-of-function" and gain of "loss of function of VAPB.2008
- Author(s)
  Kanekura K, Suzuki H, et al.
- Organizer
  第31回日本神経科学大会
- Place of Presentation
  東京東京国際フォーラム
- Year and Date
  2008-07-11
- Data Source
  KAKENHI-PROJECT-20890216
[Presentation] Two faces of the amyotrophic lateral sclerosis-linked Pro56Ser-vesicle-associated membrane protein-associated protein B (VAPB) mutant : loss of function and gain of "loss of function2008
- Author(s)
  Kanekura K, Suzuki H, et al.
- Organizer
  Society for Neuroscience Annual Meeting 2008
- Place of Presentation
  San Diego, CA, USA
- Year and Date
  2008-11-15
- Data Source
  KAKENHI-PROJECT-20890216

1. Hayamizu Yuhei (80443216)

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# of Collaborated Products: 6 results
2. Muto Jun (30383839)

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3. 峯裕 (10306730)

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7. Satoshi Narumi (40365317)

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33. MURAKAMI Yoshiki

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40. 原田裕一郎

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Kanekura Kohsuke 金蔵 孝介

金倉 孝介 カネクラ コウスケ

KANEKURA Kohsuke 金蔵 孝介

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C9ORF72変異ALSにおける非膜性オルガネラ機能障害機構の解明Principal Investigator

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Functional-structural relationship of liquid-liquid phase separation caused by ALS-causing proteins and its pathological significance.Principal Investigator

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Establishment of ALS treatment strategy using Multi-omics technologyPrincipal Investigator

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Functional analysis of the novel ALS-causative VAPB gene.Principal Investigator

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[Journal Article] How can we interpret the relationship between liquid-liquid phase separation and amyotrophic lateral sclerosis?2022

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Kanekura Kohsuke 金蔵孝介

金倉孝介カネクラコウスケ

KANEKURA Kohsuke 金蔵孝介