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Yamamoto Masayuki  山本 雅之

… Alternative Names

YAMAMOTO Masayuki  山本 雅之

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Researcher Number 50166823
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-9073-9436
External Links
Affiliation (Current) 2022: 東北大学, 医学系研究科, 教授
2022: 東北大学, 東北メディカル・メガバンク機構, 教授
Affiliation (based on the past Project Information) *help 2016 – 2022: 東北大学, 医学系研究科, 教授
2015 – 2016: 東北大学, 大学院医学系研究科, 教授
2012 – 2015: 東北大学, 医学(系)研究科(研究院), 教授
2011: 東北大学, 医学研究科, 教授
2010 – 2011: 東北大学, 医学系研究科, 教授 … More
2007 – 2011: Tohoku University, 大学院・医学系研究科, 教授
2009: 東北大学, 医学系研究科
2006: 筑波大, 人間総合科学研究科, 教授
2006: University of Tsukuba, Graduate school of Comprehensive human sciences, Professor, 大学院人間総合科学研究科, 教授
2006: 筑疲大学, 大学院・入間総合科学研究科, 教授
2005: 筑波大学, 人間総合科学研究科, 教授
2005: 筑波大学, 基礎医学系先端学際領域研究センター, 教授
2004 – 2005: University of Tsukuba, Graduate School of Comprehensive Human Sciences, Professor, 大学院・人間総合科学研究科, 教授
2004: 筑波大学, 基礎医学系学際領域研究センター, 教授
1995 – 2004: 筑波大学, 基礎医学系, 教授
2003: University of Tsukuba, Institute of Basic Medical Sciences and Center for Tsukuba Advanced Research Alliance, Professor, 基礎医学系(先端学際領域研究センター), 教授
2002 – 2003: 筑波大学, 基礎医学系先端学際領域研究センター, 教授
2001 – 2002: 筑波大学, 先端領域学際センター, 教授
2000 – 2002: 筑波大学, 基礎医学系・先端学際領域研究センター, 教授
2001: 筑波大学, 基礎医学系(先端学際領域研究センター), 教授
2001: 筑波大学, 基礎医学系先端学際領域センター, 教授
1998 – 2001: 筑波大学, TARAセンター, 教授
1999: 筑波大学, 基礎医学系最先端学際領域研究センタ, 教授
1999: Tohoku University, Graduate School of Medicine, Professor
1998 – 1999: 筑波大学, 基礎医学系先端学際領域研究センター, 教授
1995 – 1998: 筑波大学, 先端学際, 教授
1997: 筑波大学, 先端学際領域研究センター, 教授
1995: 筑波大学, 基礎医学系 先端学際領域研究センター, 教授
1991 – 1994: 東北大学, 医学部, 講師
1993: 東北大学, 医学部, 助手
1987 – 1988: 富山医科薬科大学, 医学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Biological Sciences / Pathological medical chemistry / General medical chemistry / Molecular biology / General medical chemistry / Medium-sized Section 48:Biomedical structure and function and related fields / Developmental biology / Hematology / Broad Section H / Medium-sized Section 50:Oncology and related fields … More
Except Principal Investigator
… More Pathological medical chemistry / Biological Sciences / Molecular biology / Applied veterinary science / General medical chemistry / Hematology / General medical chemistry / Pathological medical chemistry / Digestive surgery / Digestive surgery / Clinical veterinary science / Eating habits, studies on eating habits / Human pathology / Hygiene / Functional biochemistry / Environmental pharmacy / Surgical dentistry / Applied veterinary science / Hematology / Risk sciences of radiation and chemicals / Transformative Research Areas, Section (III) Less
Keywords
Principal Investigator
転写因子 / 転写制御 / 赤血球 / 細胞分化 / GATA-1 / GATA-2 / 酸化ストレス / Nrf2 / トランスジェニックマウス / 白血病 … More / NF-E2 / 造血幹細胞 / Keap1 / GATA転写因子 / 遺伝子発現制御 / bZip型転写因子 / GATA因子群 / Maf / 赤血球分化 / 異物代謝 / 環境異物 / モデル動物 / 遺伝子改変マウス / EVI1 / 遺伝子 / セルトリ細胞 / 巨核球 / 遺伝子部分破壊マウス / CNCファミリー / 親電子性物質 / 個体発生 / 白血病幹細胞 / ダウン症候群 / 低酸素 / エリスロポエチン / 発現制御 / 環境 / ストレス / 炎症 / 造血 / 染色体転座 / GATA2 / GATA転写因子群 / transcription factor / differentiation / c-Maf / 遺伝子破壊マウス / ゼブラフィッシュ / bHLH-PAS型転写因子 / ストレス応答 / T細胞受容体 / 遺伝子解析 / NF‐EZ / 細胞特異的遺伝子発現 / 生殖細胞 / プロモーター / ジーンターゲディング / ノックアウトマウス / グルタチオンS-トランスフェラーゼ / ヘムオキシゲナーゼ / 小Maf群タンパク質 / bZip構造 / 形質転換 / b-ZIP構造 / 蛋白質分解 / プロテオソーム / GATA因子 / 転写 / 基本転写因子 / クロヌチン / 自己複製能維持 / 胎児造血幹細胞 / 細胞分化方向性 / OP9ストローマ細胞 / マイクロアレイ法 / c-Kit陽性骨髄造血前駆細胞 / 発癌 / 癌抑制 / 多段階発がん / GATA1 / 幹細胞性 / 治療抵抗性 / 巨核芽球白血病 / 一過性骨髄増殖症 / 前赤芽球性性白血病 / 質的異常 / 量的異常 / Keap1造血 / 発生・分化 / 遺伝子発現 / 血液学 / 環境応答 / Nrf1 / 転写制御機構 / 神経変性疾患 / 病態代謝 / オートファジー / がん / 分子腫瘍学 / 低酸素応答 / 酸化ストレス応答 / 貧血 / 腎臓病 / 染色体逆位 / 精巣 / 遺伝子構造解析 / GATA factors / Erythroid cells / Cell defferentiation / Testis / Sertoli cells / NF-EZ / GATA因子部 / NGF-E2 / Transcription factor / Red Blood Cells / Cell differentiation / CNC family / Hematopoietic Stem Cell / NF・E2 / 血造幹細胞 / ジーンターゲティング / 血球細胞分化 / CNC転写因子群 / 遺伝子破壊 / プロモーター破壊 / 蛋白質間相互作用 / 転写因子ネットワーク / erythroid cells / hematopoietic stem cells / genetargeting / C.Maf / T細胞 / 疾患感受性 / 自己免疫疾患 / Tリンパ球 / C-Maf / transgenic mouse / T lymphocyte / autoimmune disease / 神経変性 / 遺伝子制御ネットワーク / 神経変性症 / bZip transcription factors / gene targeting / transcription / megakaryocytes / neurodegeneration / gene regulatory network / バイオモニター / マウス / electrophiles / xenobiotics / transcriptional regulation / chemicals / oxidative stress / mouse / zebrafish / b-Zip型転写因子 / DETOXIFICATION / XENOBIOTICS / TRANSCRIPTIONAL REGULATION / MODEL ANIMALS / bZip TRANSCRIPTION FACTORS / bHLH-PAS TRANSCRIPTION FACTORS / GATA-1ノックダウンマウス / アポトーシス / 骨髄異型性症候群 / GATA-1 knockdown mouse / Apoptosis / Erythroid differentiation / Myelodysplastic syndrome / Leukemia / Down syndrome / GFPノックインマウス / 条件付きノックアウトマウス / 骨髄移植 / 緑色蛍光蛋白質 / ヘマンジオブラスト / Hematopoietic stem cell / GFP knock-in mouse in the GATA-2 locus / GATA-2 conditional knock-out mouse / Bone marrow transplantation / シグナル伝達 / クロマチン構造変換 / Z-DNA / 発がん防御 / 血病 / 化学発がん / Environment / Signal transduction / Stress / Transcription regulation / Chromatin remodeling / Z-form DNA / 転座 / エンハンサー / 逆位 / Keap1-Nrf2制御系 / 加齢関連疾患 / 健康長寿 / KEAP1-NRF2系 / 前がん細胞 / NRF2 / 食道がん … More
Except Principal Investigator
転写因子 / GATA-1 / Nrf2 / GATA / 赤血球 / NF-E2 / 細胞分化 / 遺伝子 / シグナル伝達 / 鉄芽球性貧血 / トランスジェニックマウス / ノックアウトマウス / 転写制御 / 転写調節 / 酸化ストレス / 赤血球分化 / 癌遺伝子 / 遺伝子発現 / エンハンサー / エリスロポエチン / 造血幹細胞 / アポトーシス / 癌 / 膜骨格 / 赤血球膜 / 生活習慣病 / 脂肪性肝炎 / 肝発癌 / イメージング / 糖尿病 / δ-アミノレブリン酸合成酵素 / GATA-2 / erythropoietin / 標的遺伝子 / プロモーター / バンド3 / 遺伝子改変マウス / 牛 / Myb / c-kit / フェロキラターゼ / 骨髄性プロトポルフィリン症 / c-maf / 5-アミノレブリン酸合成酵素 / コアクチベータ- / 転写伸長 / ダイオキシン / maf / 白血病 / GATA転写因子 / 血液細胞 / 幹細胞 / ゲノム / 血球分化 / 小Maf群因子 / 細胞・組織 / 小胞体 / 遺伝性疾患 / 酸素 / 活性酸素種 / 細胞シグナル / 酸素生物学 / 低酸素 / ヘム生合成 / ヘム代謝 / signal transduction / CD34 / 造血前駆細胞 / p18 / ヘム / GATA-3 / in situ hybridization / 巨核球 / NF-E2p45 / Bach / 発生 / transcription factor / target genes / Hematopoiesis / Transgenic mice / HO-1 / A170 / Prx I / MSP23 / トランスジェニック / GFP / アンキリン / 小胞輸送 / membrane skeleton / band 3 / ankyrin / cattle / BTEB / BTEB2 / FGF4 / transgenic mouse / thioredoxin / ARE / CRE / NGF / promoter / Erythropoietin / gene expression / HIF-1 / L-NMMA / L-arginine / Cadmium / GATA inhibitor / Gene expression / benzo[a]pyrene / AHSP / HIF / VEGF / 膵β細胞 / Keap1 / 肥満 / 肝癌 / 遺伝子レスキューマウス / 5‐アミノレブリン酸合成酵素 / フェロキタラ-ゼ / 骨髓性プロトポルフィリン症 / 遺伝子解析 / c-Myc / 5-アミルブルン酸合成酵素 / c-myc / c-myb / ES細胞 / 遺伝子破壊マウス / STAT / Ahリセプター / 遺伝子欠損マウス / 種特異的転写 / リン酸化 / ホモダイマー / ヘテロダイマー / 相互作用 / マクロファージ / NMR / TBP / ロイシンジッパー / 殺菌機構 / 転写制御因子 / RNAポリメラーゼ / 受容体 / コアクチベター / インヒビター / 食道癌 / 増殖因子 / aFGF / bFGF / amphiregulin / Midkine / hst-1 / EGFR / 細胞分化決定 / 転写 / mafK / 赤白血病 / 二量体 / bZip / セルトリ細胞 / 精子形成 / 基本転写装置 / コリプレッサー / two hybrid法 / マスト細胞 / T細胞 / 骨髄形成 / 遺伝子ターゲティング / 白血球 / 悪性リンパ腫 / アレーCGH / トランスレーショナルリサーチ / マイクロアレー / トランスレーショナリサーチ / MALTリンパ腫 / MALT1 / API2 / API2-MALT1 / MAT1 / 遺伝学 / ウイルス / 細胞組織 / ウィルス / 細胞膜 / トラフィック / 疾患 / 遺伝 / アニオン交換輸送体1 / 機能性食品 / 分子標的治療 / エピジェネティクス / 細胞周期 / 核酸 / 発現制御 / 発生・分化 / バイオテクノロジー / Fucci細胞 / 骨髄異形成症候群 / miRNA / Keap1-Nrf2システム / 生体イメージング / ハイポキシア / ラット / 調節領域 / δーアミノレブリン酸合成酵素 / フィードバック調節 / delta-aminolevulinate synthase / heme biosynthesis / gene / rat / regulatory region / ポルフィリン症 / ヘム代謝調節 / 先天異常 / コプロポルフィリノーゲンオキシダーゼ / ウロポルフィリノーゲンデカルボキシラーゼ / δ-アミノレブリン酸脱水酵素 / Porphyria / Regulation of Heme Metabolism / Genetic Diorder / 細胞増殖 / 細胞死 / 細胞間相互作用 / がん転移 / ヒトがん / がん遺伝子 / がん抑制遺伝子 / がん細胞 / DNA修復 / ヒトゲノム / 2国間共同研究 / cell growth / cell differentiation / apoptosis / cell-cell interaction / cancer metastasis / human cancer / oncogene / tumor suppressor gene / 受容体型チロシンキナーゼ / IL-6可溶性受容体 / 血液幹細胞 / AGM領域 / 細胞運命決定因子 / 自己複製能 / 多分化能 / gp130 / 蛍光細胞分離装置 / IL-6 / 幹細胞増幅 / hemotopoietic stem cells / receptor tyroshine kinases / IL-6R / 赤血球系転写因子 / ヘム合成 / グロビン合成 / 鉄芽球系貧血 / δ-アミルブリン酸合成酵素 / 先天性ヘム代謝障害 / delta-Aminolevulinate synthase / erythroid transcription factor / heme bicsynthesis / globin biosynthesis / 炎症性腸疾患 / 大腸癌 / GATA遺伝子 / in situハイブリダイゼーション / 炎症 / Inflammatory Bowel Disease / Colon cancer / GATA gene / NF-E2 p45 / 増血幹細胞 / トロンボポエチン / MPL / ETSファミリー / megakaryoyte / erythrocyte / hematopoietic stem cell / thrombopoetin / KNOCKOUT MOUSE / 転写共役因子 / 転写因子間相互作用 / 作用機構 / 転写開始 / 報告書 / シンポジウム / 基本転写因子 / 転写伸長反応 / クロマチン再構成系による転写機構 / DNA結合転写調節因子 / シグナル伝達と転写因子 / 総括班会議 / ニュースレター / コンファランス / 研究成果集 / ワークショップ / 公開シンポジウム / 幹細胞と遺伝子発現制御 / 公募研究 / 転写調節から疾患 / 遺伝学的アプローチ / 研究報告書 / 構造生物学 / 合同シンポジウム / 冬のワークショップ / 共同研究 / 中間報告 / 形態形成 / transcriptional cofactor / inter-transcriptional interaction / functional echanism / transcription initiation / transcription elongation / stem cells / 制御因子 / 変異マウス / 転写仲介因子 / 造血系 / 神経系 / 分化 / transcriptional control / transcriptional regulator / mutant mice / transcriptional mediators / development / hematopoietic system / neuronal system / Th1 / Th2 / 自己免疫疾患 / c-Maf / Transgenic mouse / T lymphocyte / Autoimmune disease / Transcription factor / 遺伝子治療 / 赤芽球系造血 / 家畜 / Gene therapy / transcription factors / Promoters / Enhancers / Band 3 / Inberited disorders / 赤血球系細胞 / 鉄代謝 / 環状鉄芽球 / モデル動物 / Heme / Erythroid cells / Knockout mice / PrxI / 酸化LDL / LDL / GATA因子群 / ジーンターゲティング / CATA transcription factors / Transcription factors / Gene tragetting / ゼブラフィッシュ / トランスジェニックフィッシュ / 正のフィードバック機構 / GTAT-1 / 橋渡し分子 / Zebrafish / Erythropoiesis / Transcriptional Regulation / Transgenic fish / Positive autoregulation / 遺伝性溶血性貧血 / プロテアゾーム / 遺伝性溶血性貧 / プロテアソーム / 膜蛋白質 / 膜移行 / 遺伝性バンド3欠損症 / red cell membranes / congenital hemolytic anemia / proeasome / vesicle trafficking / 有害化学物質 / 遺伝子改変動物 / バイオアッセイ / 毒性評価 / ダイオキシン類 / 環境リスク / toxic chemicals / genetically altered mice / bioassay system / toxicological assessment / dioxins / ターゲティングベクター / GCbox配列 / 遺伝子欠失マウス / 小脳 / 海馬 / ターゲッティングペクター / ホモ欠失マウス / in vitro / β-gal / T_3 / targeting vectors / GCbox consensus sequence / gene-knockout mice / cerebellum / hippocampus / 胞体突起形成 / サブトラクション / small Maf proteins / megakaryocytes / proplatelet formation / transcription / subtraction / 3-methylcholanthrene / NFG / 神経突起伸長 / ヘミン / Oxidative stress / Hydrogen peroxide / 変異原物質 / gpt deltaマウス / ディーゼル排気 / ベンゾ[a]ピレン / ニトロピレン / 遺伝子導入マウス / 体内突然変異 / 変異原物質検出 / Nrf2ノックアウトマウス / 変異物質検出 / 1,6-ジニトロピレン / Benzo(a)pyrene / mutagen / gpt delta mouse / diesel exhaust / nitropyrene / in vivo mutagenesis / 赤芽球分化 / 培養細胞 / 赤芽球系分化 / 膜骨格タンパク質 / スペクトリン / erythroid development / red blood cell / membrane trafficking / intracellular vesicles / cell culture / ペルオキシレドキシン / ジーントラップ / Peroxiredoxin / knockout mouse / gene trapping / プリオン病 / 分子診断 / サイトカイン / 人獣共通感染症 / PrPc(cellular prion protein) / prion diseases / molecular diagnosis / hematopoietic precursor cells / cytokine / transcription regulation / zoonosis / エリストポエチン / 酸素センサー / hypoxia inducible factor-1 / K-11706 / vascular endothelial growth factor / 2-oxoglutarate / 血管形成 / enhancer / 複数遺伝子の協調的発現 / グリシン開裂系 / グリシン脱炭酸酵素cDNA / Hー蛋白cDNA / 遺伝子の臓器特異的発現調節 / H-蛋白cDNA / 鶏ゲノムDNAライブラリー / グリシン脱炭酸酵素遺伝子 / H-蛋白遺伝子 / 高グリシン血症 / coupled expression of the genes / glycine decarboxylase cDNA / H-protein cDNA / glycine cleavage system / センサー / 遺伝子改変 / 生体分子 / 腎性尿崩症 / セレノシステイン / 代謝学 / インスリン抵抗性 / レプチン抵抗性 / 視床下部 / 臓器レスキューマウス / 非アルコール性脂肪性肝疾患 / 腸内細菌 / 病態生理 / 肥満関連肝疾患 / 紫外線 / 皮膚 / MIS応答 / 突然変異 / DNA損傷 / 遺伝子組換えマウス / 活性酸素 / 環境応答 / Mrf2 / 環境 / 細胞･組織 / セレノプロテイン / NRF2 / 抗酸化システム / 還元ストレス Less

  • Research Projects

    (93 results)

  • Research Products

    (1,286 results)

  • Co-Researchers

    (381 People)

  •  Role of precancerous cells as components of the tumor microenvironmentPrincipal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2022 – 2023
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 50:Oncology and related fields
    • Research Institution
      Tohoku University

  •  Regulation of signal transduction via crosstalk between supersulfide and selenium

    • Principal Investigator
      斎藤 芳郎
    • Project Period (FY)
      2021 – 2025
    • Research Category
      Grant-in-Aid for Transformative Research Areas (A)
    • Review Section
      Transformative Research Areas, Section (III)
    • Research Institution
      Tohoku University

  •  Deciphering Molecular Basis for the Anti-Oxidative Stress Response and Application of the Basis for Disease Prevention and TherapyPrincipal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2019 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Review Section
      Broad Section H
    • Research Institution
      Tohoku University

  •  生体の酸化ストレス応答の分子メカニズム解明とその疾病予防・治療への応用Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2019
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Tohoku University

  •  Elucidation of cytoprotective mechanisms by structural analysis of stress sensor Keap1Principal Investigator

    • Principal Investigator
      Yamamoto Masayuki
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 48:Biomedical structure and function and related fields
    • Research Institution
      Tohoku University

  •  Promotion of oxygen biology on the basis of international networks

    • Principal Investigator
      Mori Yasuo
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Mechanisms of leukemogenesis by the leukemia-driving enhancerPrincipal Investigator

    • Principal Investigator
      Yamamoto Masayuki
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University

  •  The role of Nrf2 in development and carcinogenesis of NASH using gene rescue mice

    • Principal Investigator
      ISHIGE Kazunori
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Digestive surgery
    • Research Institution
      University of Tsukuba

  •  Mecahistic analysis of a protective response of skin tissue to UV genotoxicity

    • Principal Investigator
      IKEHATA Hironobu
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Risk sciences of radiation and chemicals
    • Research Institution
      Tohoku University

  •  Oxygen biology: a new criterion for integrated understanding of life

    • Principal Investigator
      Mori Yasuo
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University

  •  Systemic mechanisms of response to hypoxic stressesPrincipal Investigator

    • Principal Investigator
      Yamamoto Masayuki
    • Project Period (FY)
      2014 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University

  •  Identification of leukemia-initiating cells in an inv(3)(q21q26) mouse modelPrincipal Investigator

    • Principal Investigator
      Yamamoto Masayuki
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Hematology
    • Research Institution
      Tohoku University

  •  The role of Nrf2 in pancreatic beta-cells; a study of new pancreatic beta-cell specific Nrf2 activation model mice

    • Principal Investigator
      Yoko Yagishita
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  Search for novel physiological function of transcriptional factor Nrf2

    • Principal Investigator
      Suzuki Takafumi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University

  •  The role of Nrf2 in oxidative stress-mediated insulin resistance

    • Principal Investigator
      Akira Uruno
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  The regulatory role of Nrf2 in pathogenesis and carcinogenesis of NASH using gene rescued mice

    • Principal Investigator
      ISHIGE Kazunori
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Digestive surgery
    • Research Institution
      University of Tsukuba

  •  Roles of stress-responsive transcription factors in health and diseasePrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University

  •  Analysis of leukemogenesis caused by disruption of gene regulatory mechanisms mediated by multiple transactivation domainsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  Mechanism of Nrf2-mediated self-renewal of hematopoietic stem cellsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2011
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  Crosstalk between chromosome modification and transcription factors in the differentiation of hematopoietic cells

    • Principal Investigator
      KITAMURA Toshio
    • Project Period (FY)
      2010 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo

  •  転写因子Nrf1の神経細胞恒常性維持機構の解明Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University

  •  The role of Keap1-Nrf2 system in oxidative stress response of pancreatic β-cells

    • Principal Investigator
      URUNO Akira
    • Project Period (FY)
      2010 – 2011
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Research Field
      General medical chemistry
    • Research Institution
      Tohoku University

  •  Novel prevention of development of life style-related liver diseases and liver carcinogenesis through an activation of transcription factor induced by functional foods

    • Principal Investigator
      UTSUNOMIYA Hirotoshi, 中原 朗
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Eating habits, studies on eating habits
    • Research Institution
      Wakayama Medical University
      University of Tsukuba

  •  From the ER to the plasma membrane : Vesicular transport of membrane skeleton units and the diseases

    • Principal Investigator
      INABA Mutsumi
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Clinical veterinary science
    • Research Institution
      Hokkaido University

  •  Molecular Mechanisms of Adaptive Responses to Food and OxygenPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Tohoku University

  •  転写因子の発現量依存的な細胞運命決定機構の解明Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University
      University of Tsukuba

  •  Roles of transcription factors for carcinogenesis and carcinogenesisdefensePrincipal Investigator

    • Principal Investigator
      MASAYUKI Yamamoto
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tohoku University
      University of Tsukuba

  •  Study for the molecular mechanism of oxidative stress responsive transcriptionPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba

  •  Genetic and Epigenetic Dysregulation in Cancer

    • Principal Investigator
      NODA Tetsuo
    • Project Period (FY)
      2004 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Japanese Foundation For Cancer Research
      Tohoku University

  •  Molecular pathology for down-regulation of erythroid-specific genes in prion diseases

    • Principal Investigator
      INABA Mutsumi
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      Hokkaido University

  •  Gene manipulation of hypoxia inducible gene regulation

    • Principal Investigator
      IMAGAWA Shigehiko
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      University of Tsukuba

  •  Transcription factor regulation of malignant cell transformation and its repressionPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba

  •  Molecular mechanisms for hemato-vascular formationPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

  •  赤芽球の増殖・分化・アポトーシスの制御におけるGATA因子の役割の解明Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tsukuba

  •  転写制御複合体形成のダイナミクスとその生物機能の解明Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      University of Tsukuba

  •  分化方向性の制御から挑む再生医工学Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

  •  Sensitive detection of air-born mutagens and their evaluation using gene knockout mice

    • Principal Investigator
      AOKI Yasunobu
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Environmental pharmacy
    • Research Institution
      National Institute for Environmental Studies

  •  Molecular mechanisms for the assembly of the red cell membrane skeleton during erythroid cell development

    • Principal Investigator
      INABA Mutsumi
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      HOKKAIDO UNIVERSITY

  •  Analysis of lymph node metastasis of oral cancer by using peroxiredoxin I knockout mouse

    • Principal Investigator
      YOSHIDA Hiroshi
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      University of Tsukuba

  •  Construction of a repertoire of genetically altered mice for evaluating the toxicity of chemicals

    • Principal Investigator
      MAEDA Shuichiro
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Hygiene
    • Research Institution
      University of Yamanashi
      山梨医科大学

  •  Functional analysis of BTEB and BTEB2 transcription factors by gene-targeting technology

    • Principal Investigator
      FUJII Yoshiaki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Functional biochemistry
    • Research Institution
      University of Tsukuba
      Tohoku University

  •  Functional Contribution of Small Maf Proteins in Hematopoietic Cells

    • Principal Investigator
      MOTOHASHI Hozumi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

  •  Investigation of biological function of thioredoxin by construction of thioredoxin knock down mice

    • Principal Investigator
      MASUTANI Hiroshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      KYOTO UNIVERSITY

  •  Gene Modification of Oxygen Responsiveness by Erythropoietin Gene

    • Principal Investigator
      IMAGAWA Shigehiko
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      University of Tsukuba

  •  転座関連遺伝子及び転写因子による細胞分化とがん化の分子機構

    • Principal Investigator
      瀬戸 加大
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Aichi Cancer Center Research Institute

  •  Analysis of biological function of regulatory network composed of bZip transcription factorsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      University of Tsukuba

  •  Molecular mechanism for the assembly of red cell membrane skeletons based on pathobiology of congenital hemolytic anemia in cattle

    • Principal Investigator
      INABA Mutsumi
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      The University of Tokyo

  •  Development of monitoring system of toxic chemicals base on the Nrf2-dependent detoxification pathwayPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba

  •  APPLICATION OF GENE MANIPULATION TECHNOLOGY TO GENERATION OF MODEL ANIMALS FOR ENVIRONMENTAL ASSESSMENTPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for University and Society Collaboration
    • Research Field
      Pathological medical chemistry
    • Research Institution
      UNIVERSITY OF TSUKUBA

  •  血液細胞の分化と機能発現の制御機構の解明Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      University of Tsukuba

  •  Nrf2による新しい酸化ストレス応答機構の解析Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba

  •  Study on a new defence system against oxidative stress

    • Principal Investigator
      ISHII Tetsuo
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba

  •  Analysis of GATA transcription factors functions on development and differentiation of hematopoietic cells.

    • Principal Investigator
      TAKAHASHI Satoru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

  •  Function of bridging molecules in enhancer-promoter communication during erythropoieis

    • Principal Investigator
      KOBAYASHI Makoto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Molecular biology
    • Research Institution
      University of Tsukuba

  •  転写調節による造血分化制御

    • Principal Investigator
      仲野 徹
    • Project Period (FY)
      1998 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University

  •  Applications of Tissue-specific Transcription Factor in Animal Gene Therapy

    • Principal Investigator
      INABA Mutsumi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      The University of Tokyo

  •  Gene manipulation of heme synthetic pathway enzymes

    • Principal Investigator
      HAYASHI Norio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  エリスロポエチン遺伝子の発現調節機構の解析

    • Principal Investigator
      IMAGAWA Shigehiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Hematology
    • Research Institution
      Jichi Medical University

  •  小Maf群転写因子を用いた形質転換細胞の分化誘導Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba

  •  GENETIC CONTROL OF HEMATOPOIETIC CELL DOFFERENTIATION

    • Principal Investigator
      IGARASHI Kazuhiko
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Molecular biology
    • Research Institution
      Tohoku University
      University of Tsukuba

  •  Transcriptional mechanisms controlling organized function in vertebrate

    • Principal Investigator
      FUJII-KURIYAMA Yoshiaki
    • Project Period (FY)
      1997 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tohoku University

  •  Target genes and biological role of transcription factors in animal

    • Principal Investigator
      ISHII Shunsuke
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      RIKEN INSTITUTE

  •  Regulation and Function of Erythroid Transcription Factors.Principal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      University of Tsukuba

  •  Regulation of Disease Susceptibility through Gene Introduction of Transcriptiom Factors.Principal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

  •  Development of New Therapeutic Strategy for Autoimmune Diseases through Gene Introduction of Oncogene c-maf.

    • Principal Investigator
      TAKAHASHI Satoru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba

  •  細胞の機能分化に関わる遺伝子制御ネットワーク-転写因子間相互作用-

    • Principal Investigator
      FUJII-KURIYAMA Yoshiaki, HANDA Hiroshi
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University
      Tokyo Institute of Technology

  •  生殖細胞と支持細胞の機能的連関とGATA転写因子群

    • Principal Investigator
      高橋 智
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Tsukuba

  •  高等動物細胞の遺伝子発現における転写因子の相互作用と生物作用の分子機構

    • Principal Investigator
      藤井 義明
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      Tohoku University

  •  Transcription factors regulating the erytnroid and megakaryocytic cell differentiation.

    • Principal Investigator
      MINEGISHI Naoko
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      University of Tsukuba
      Tohoku University

  •  転写因子群による赤血球特異的な遺伝子発現制御機序の解析Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Tsukuba

  •  赤血球系転写因子群とMaf関連蛋白質による赤血球分化の制御とその異常の解析

    • Principal Investigator
      五十嵐 和彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  生殖細胞と支持細胞の機能的関連とGATA転写因子群Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      University of Tsukuba

  •  Molecular Mechanism of Erythroid Differentiation

    • Principal Investigator
      FUJITA Hiroyoshi
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  Multiple transcription factors regulation of erythroid cell differeutiation mechanisms.Principal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      University of Tsukuba

  •  Possible involvement of vascular cells-related transcription factors in human inflammatory diseases and cancer tissue.

    • Principal Investigator
      OHTANI Haruo
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Tohoku University

  •  転写因子群による赤血球特異的な遺伝子発現調節機序の解析Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  細胞分化の決定と癌遺伝子の役割

    • Principal Investigator
      帯刀 益夫
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  癌遺伝子mafの関連遺伝子産胸による赤血球系転写因子NF-E2の機能変換

    • Principal Investigator
      五十嵐 和彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  GATA転写因子群による細胞特異的転写調節機序の解析Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Developmental biology
    • Research Institution
      Tohoku University

  •  Cooperation and information exchange with European countries.

    • Principal Investigator
      KUROKI Toshio
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Showa University
      The University of Tokyo

  •  Purification and ampliefication of hematopoietic stem cells

    • Principal Investigator
      SUDA Toshio
    • Project Period (FY)
      1994 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University

  •  細胞分化の決定と癌遺伝子の役割

    • Principal Investigator
      帯刀 益夫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University

  •  ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症

    • Principal Investigator
      林 典夫
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  GATA転写因子群をコードする遺伝子の構造と発現調節機序の解析Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  食道癌に発現する増殖因子の検討-食道癌の増殖の特性と悪性度に関連して-

    • Principal Investigator
      片山 正文
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Tohoku University

  •  Molecular analyzes of heme regulation and its disorders.

    • Principal Investigator
      SHIBAHARA Shigeki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tohoku University

  •  細胞分化の決定と癌移伝子の役割

    • Principal Investigator
      帯刀 益夫
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Tohoku University

  •  ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髄性プロトポルフィリン症

    • Principal Investigator
      林 典夫
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  Structure and function of the regulatory region of the gene encoding non-specific form delta-aminolevulinate synthase

    • Principal Investigator
      HAYASHI Norio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  Analysis of the erythroid-specific gene expression by GATA trenscription factorsPrincipal Investigator

    • Principal Investigator
      YAMAMOTO Masayuki
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Tohoku University

  •  転写因子GATA(NF‐EI)群をコ-ドする遺伝子の構造と発現調節機序の解析Principal Investigator

    • Principal Investigator
      山本 雅之
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  ヘム生合成異常による病態の分子機構:鉄芽球性貧血および骨髓性プロトポルフィリン症

    • Principal Investigator
      林 典夫
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tohoku University

  •  Coupled Expression of The Genes Encoding The Constituents of The Glycine Cleavage System in Chicken

    • Principal Investigator
      HIRAGA Koichi
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      Toyama Medical and Pharmaceutical University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001 1999 1998 Other

All Journal Article Presentation Book Patent

  • [Book] 人体の細胞生物学 : カラー図解　第３章3.遺伝子発現の調節2018
    • Author(s)
      鈴木隆史、山本雅之
    • Total Pages
      271
    • Publisher
      日本医事新報社
    • ISBN
      9784784932320
    • Data Source
      KAKENHI-PROJECT-18K19417

  • [Book] 肝胆膵 HER family：肝内胆管癌のpotential drug targets2016
    • Author(s)
      川本 徹，山本雅一，正田純一
    • Total Pages
      176
    • Publisher
      メディカルビュー社
    • Data Source
      KAKENHI-PROJECT-15K15488

  • [Book] New Horizon of Herbal Medicines2016
    • Author(s)
      Shoda J, Warabi E, Okada K, Yamamoto M
    • Total Pages
      264
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-26293297

  • [Book] 肝胆膵 HER family：肝内胆管癌のpotential drug targets2016
    • Author(s)
      川本 徹，山本雅一，正田純一
    • Total Pages
      176
    • Publisher
      メディカルビュー社
    • Data Source
      KAKENHI-PROJECT-26293297

  • [Book] New Horizon of Herbal Medicines2016
    • Author(s)
      Shoda J, Warabi E, Okada K, Yamamoto M
    • Total Pages
      264
    • Publisher
      Springer
    • Data Source
      KAKENHI-PROJECT-15K15488

  • [Book] Molecular Nutrition and Diabetes. Section 3, 34. Nrf2-mediated gene regulations and glucose homeostasis2015
    • Author(s)
      Yoko Yagishita, Akira Uruno, Masayuki Yamamoto
    • Publisher
      Elsevier.B.V.
    • Data Source
      KAKENHI-PROJECT-26893008

  • [Book] Molecular Nutrition and Diabetes, 1st Edition.2015
    • Author(s)
      Yagishita Y, Uruno A, Yamamoto M
    • Total Pages
      400
    • Publisher
      Elsevier Science B.V.
    • Data Source
      KAKENHI-PROJECT-26460383

  • [Book] Molecular Nutrition and Diabetes2015
    • Author(s)
      Yagishita Y, Uruno A and Yamamoto M.
    • Total Pages
      400
    • Publisher
      Elsevier
    • Data Source
      KAKENHI-PROJECT-26893008

  • [Book] 肝内胆管癌の新規バイオマーカー2014
    • Author(s)
      正田純一，松田厚志，久野　敦，池原　譲，成松　久，大河内信弘，山本雅一，中沼安二
    • Total Pages
      3
    • Publisher
      Hepatology Practice 文光堂
    • Data Source
      KAKENHI-PROJECT-26293297

  • [Book] がんー疾患モデルの作製と利用2012
    • Author(s)
      鈴木未来子,山本雅之(分担執筆)
    • Data Source
      KAKENHI-PROJECT-24659142

  • [Book] Gallbladder Cancer-Pathogenesis and Molecular Targeting Strategies for Therapeutic Options.(Gallbladder Cancer, Christopher V Aiello)2012
    • Author(s)
      Shoda, J, Kawamoto T, Yamamoto, M
    • Publisher
      NOVA Science Publishers(In press)
    • Data Source
      KAKENHI-PROJECT-21300275

  • [Book] 腎と透析2010
    • Author(s)
      峯岸直子、山本雅之
    • Publisher
      東京医学社
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Book] Diabetes Frontier2010
    • Author(s)
      宇留野晃、森口尚、山本雅之
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Book] Diabetes Frontier2010
    • Author(s)
      宇留野晃、森口尚、山本雅之
    • Publisher
      メディカルレビュー社
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Book] 転写制御とエピジェネティクス-ゲノムでコードに向けて-2008
    • Author(s)
      鈴木隆史、山本雅之
    • Publisher
      南山堂
    • Data Source
      KAKENHI-PROJECT-17013017

  • [Book] Keap1-Nrf2システムによる酸化ストレス・親電子性物質応答機構「酸化ストレスの医学」2008
    • Author(s)
      小林聡・山本雅之
    • Publisher
      診断と治療社
    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf22022
    • Author(s)
      Dayalan Naidu S、Suzuki T、Dikovskaya D、Knatko EV、Higgins M、Sato M、Novak M、Villegas JA、Moore TW、Yamamoto M、Dinkova-Kostova AT.
    • Journal Title

      iScience

      Volume: 25 Pages: 103703-103703

    • DOI

      10.1016/j.isci.2021.103703

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-17KK0183, KAKENHI-PROJECT-19H05649

  • [Journal Article] Target Gene Diversity of the Nrf1-MafG Transcription Factor Revealed by a Tethered Heterodimer2022
    • Author(s)
      Katsuoka Fumiki、Otsuki Akihito、Hatanaka Nozomi、Okuyama Haruna、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 42

    • DOI

      10.1128/mcb.00520-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-20K07335

  • [Journal Article] Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration.2022
    • Author(s)
      Nakai Taku、Saigusa Daisuke、Iwamura Yuma、Matsumoto Yotaro、Umeda Keiko、Kato Koichiro、Yamaki Hayato、Tomioka Yoshihisa、Hirano Ikuo、Koshiba Seizo、Yamamoto Masayuki、Suzuki Norio
    • Journal Title

      Biochem Pharmacol

      Volume: 197 Pages: 114939-114939

    • DOI

      10.1016/j.bcp.2022.114939

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-21J21975

  • [Journal Article] Gene expression changes related to bone mineralization, blood pressure and lipid metabolism in mouse kidneys after space travel.2022
    • Author(s)
      Suzuki Norio、Iwamura Yuma、Nakai Taku、Kato Koichiro、Otsuki Akihito、Uruno Akira、Saigusa Daisuke、Taguchi Keiko、Suzuki Mikiko、Shimizu Ritsuko、Yumoto Akane、Okada Risa、Shirakawa Masaki、Shiba Dai、Takahashi Satoru、Suzuki Takafumi、Yamamoto Masayuki
    • Journal Title

      Kidney Intternational

      Volume: 101 Pages: 92-105

    • DOI

      10.1016/j.kint.2021.09.031

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-17KK0183, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-20H03374, KAKENHI-PROJECT-21J21975, KAKENHI-PROJECT-20K07352

  • [Journal Article] AHR and NRF2 in Skin Homeostasis and Atopic Dermatitis2022
    • Author(s)
      Edamitsu T, Taguchi K, Okuyama R, Yamamoto M
    • Journal Title

      Antioxidants

      Volume: 11 Pages: 227-227

    • DOI

      10.3390/antiox11020227

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07395, KAKENHI-PROJECT-19H05649

  • [Journal Article] Multifaceted Roles of the KEAP1-NRF2 System in Cancer and Inflammatory Disease Milieu2022
    • Author(s)
      Panda Harit、Wen Huaichun、Suzuki Mikiko、Yamamoto Masayuki
    • Journal Title

      Antioxidants

      Volume: 11 Pages: 538-538

    • DOI

      10.3390/antiox11030538

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Distinct Regulations of HO-1 Gene Expression for Stress Response and Substrate Induction2021
    • Author(s)
      Zhang Anqi、Suzuki Takafumi、Adachi Saki、Naganuma Eriko、Suzuki Norio、Hosoya Tomonori、Itoh Ken、Sporn Michael B.、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 41

    • DOI

      10.1128/mcb.00236-21

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-17KK0183, KAKENHI-PROJECT-19H05649

  • [Journal Article] Nrf2 plays a critical role in the metabolic response during and after spaceflight.2021
    • Author(s)
      Uruno A、Saigusa D、Suzuki T、Yumoto A、Nakamura T、Matsukawa N、Yamazaki T、Saito R、Taguchi K、Suzuki M、Suzuki N、Otsuki A、Katsuoka F、Hishinuma E、Okada R、Koshiba S、Tomioka Y、Shimizu R、Shirakawa M、Kensler TW.、Shiba D、Yamamoto M
    • Journal Title

      Commun Biol.

      Volume: 4 Pages: 1381-1381

    • DOI

      10.1038/s42003-021-02904-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H03555, KAKENHI-PROJECT-20H03374, KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-20K07352

  • [Journal Article] The KEAP1-NRF2 system as a molecular target of cancer treatment2021
    • Author(s)
      Taguchi K, Yamamoto M
    • Journal Title

      Cancers

      Volume: 13 Pages: 46-46

    • DOI

      10.3390/cancers13010046

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07395, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-16H06276

  • [Journal Article] CL316243 treatment mitigates the inflammation in white adipose tissues of juvenile adipocyte-specific Nfe2l1 knockout mice2021
    • Author(s)
      Wang Zhendi、Hou Yongyong、Ren Suping、Liu Zhiyuan、Zuo Zhuo、Huang Sicui、Wang Wanqi、Wang Huihui、Chen Yanyan、Xu Yuanyuan、Yamamoto Masayuki、Zhang Qiang、Fu Jingqi、Pi Jingbo
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 165 Pages: 289-298

    • DOI

      10.1016/j.freeradbiomed.2021.01.043

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Novel method for evaluating the health condition of mice in space through a video downlink2021
    • Author(s)
      YUMOTO Akane、KOKUBO Toshiaki、IZUMI Ryutaro、SHIMOMURA Michihiko、FUNATSU Osamu、TADA Motoki N.、OTA-MURAKAMI Naoko、IINO Kayoko、SHIRAKAWA Masaki、MIZUNO Hiroyasu、KUDO Takashi、TAKAHASHI Satoru、SUZUKI Takafumi、URUNO Akira、YAMAMOTO Masayuki、SHIBA Dai
    • Journal Title

      Experimental Animals

      Volume: - Issue: 2 Pages: 236-244

    • DOI

      10.1538/expanim.20-0102

    • NAID

      130008037417

    • ISSN
      0007-5124, 1341-1357, 1881-7122
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-20K07352, KAKENHI-PROJECT-19H05649

  • [Journal Article] Identification of Dominant Transcripts in Oxidative Stress Response by a Full-Length Transcriptome Analysis2021
    • Author(s)
      Otsuki Akihito、Okamura Yasunobu、Aoki Yuichi、Ishida Noriko、Kumada Kazuki、Minegishi Naoko、Katsuoka Fumiki、Kinoshita Kengo、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 41 Pages: 1-18

    • DOI

      10.1128/mcb.00472-20

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K07335, KAKENHI-PROJECT-20K12157, KAKENHI-PROJECT-17K08617, KAKENHI-PROJECT-17K10432, KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-19H05649

  • [Journal Article] The Transcription Factor MAFF Regulates an Atherosclerosis Relevant Network Connecting Inflammation and Cholesterol Metabolism2021
    • Author(s)
      von Scheidt Moritz、Zhao Yuqi、de Aguiar Vallim Thomas Q.、Che Nam、Wierer Michael、Seldin Marcus M.、Franzen Oscar、Kurt Zeyneb、Pang Shichao、Bongiovanni Dario、Yamamoto Masayuki、Edwards Peter A.、Ruusalepp Arno、Kovacic Jason C.、Mann Matthias、Bjorkegren Johan L.M.、Lusis Aldons J.、Yang Xia、Schunkert Heribert
    • Journal Title

      Circulation

      Volume: -

    • DOI

      10.1161/circulationaha.120.050186

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Nrf2 is activated by disruption of mitochondrial thiol homeostasis but not by enhanced mitochondrial superoxide production2021
    • Author(s)
      Cvetko Filip、Caldwell Stuart T.、Higgins Maureen、Suzuki Takafumi、Yamamoto Masayuki、Prag Hiran A.、Hartley Richard C.、Dinkova-Kostova Albena T.、Murphy Michael P.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 296 Pages: 100169-100169

    • DOI

      10.1074/jbc.ra120.016551

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-19H05649

  • [Journal Article] Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition2021
    • Author(s)
      Hamada S, Matsumoto R, Tanaka Y, Taguchi K, Yamamoto M, Masamune A.
    • Journal Title

      Int J Mol Sci .

      Volume: 22 Pages: 1870-1870

    • DOI

      10.3390/ijms22041870

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K08300, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H03631

  • [Journal Article] Possible Roles of Proinflammatory Signaling in Keratinocytes Through Aryl Hydrocarbon Receptor Ligands for the Development of Squamous Cell Carcinoma2020
    • Author(s)
      Sato Yota、Fujimura Taku、Hidaka Takanori、Lyu Chunbing、Tanita Kayo、Matsushita Shigeto、Yamamoto Masayuki、Aiba Setsuya
    • Journal Title

      Frontiers in Immunology

      Volume: 11 Pages: 534323-534323

    • DOI

      10.3389/fimmu.2020.534323

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Nrf2 antioxidative system is involved in cytochrome P450 gene expression and activity: a delay in pentobarbital metabolism in Nrf2-deficient mice2020
    • Author(s)
      Ashino Takashi、Yamamoto Masayuki、Numazawa Satoshi
    • Journal Title

      Drug Metab Dispos

      Volume: 48 Pages: 673-680

    • DOI

      10.1124/dmd.120.000010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K06633, KAKENHI-PROJECT-18K08115

  • [Journal Article] Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice2020
    • Author(s)
      Tamatam Chandra M.、Reddy Narsa M.、Potteti Haranatha R.、Ankireddy Aparna、Noone Patrick M.、Yamamoto Masayuki、Kensler Thomas W.、Reddy Sekhar P.
    • Journal Title

      Scientific Reports

      Volume: 10 Pages: 19034-19034

    • DOI

      10.1038/s41598-020-75834-8

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Keap1 deletion accelerates mutant K-ras/p53-driven cholangiocarcinoma2020
    • Author(s)
      1.Nabeshima T, Hamada S, Taguchi K, Tanaka Y, Matsumoto R, Yamamoto M, Masamune A
    • Journal Title

      American Journal of Physiology-Gastrointestinal and Liver Physiology

      Volume: 318

    • DOI

      10.1152/ajpgi.00296.2019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07395, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K19417

  • [Journal Article] Association of single nucleotide polymorphisms in the NRF2 promoter with vascular stiffness with aging2020
    • Author(s)
      Shimizu Sunao、Mimura Junsei、Hasegawa Takanori、Shimizu Eigo、Imoto Seiya、Tsushima Michiko、Kasai Shuya、Yamazaki Hiromi、Ushida Yusuke、Suganuma Hiroyuki、Tomita Hirofumi、Yamamoto Masayuki、Nakaji Shigeyuki、Itoh Ken
    • Journal Title

      PLOS ONE

      Volume: 15

    • DOI

      10.1371/journal.pone.0236834

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Fundamental Biological Features of Spaceflight: Advancing the Field to Enable Deep-Space Exploration2020
    • Author(s)
      Afshinnekoo Ebrahim、Scott Ryan T.、MacKay Matthew J.、Pariset Eloise、Cekanaviciute Egle、Barker Richard、Gilroy Simon、Hassane Duane、Smith Scott M.、Zwart Sara R.、Nelman-Gonzalez Mayra、Crucian Brian E.、Ponomarev Sergey A.、Orlov Oleg I.、Shiba Dai、Muratani Masafumi、Yamamoto Masayuki、以降著者省略
    • Journal Title

      Cell

      Volume: 183 Pages: 1162-1184

    • DOI

      10.1016/j.cell.2020.10.050

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-20H03234

  • [Journal Article] Impacts of NRF2 activation in non-small‐cell lung cancer cell lines on extracellular metabolites2020
    • Author(s)
      Saigusa Daisuke、Motoike Ikuko N.、Saito Sakae、Zorzi Michael、Aoki Yuichi、Kitamura Hiroshi、Suzuki Mikiko、Katsuoka Fumiki、Ishii Hirofumi、Kinoshita Kengo、Motohashi Hozumi、Yamamoto Masayuki
    • Journal Title

      NPJ Aging Mech Dis

      Volume: 111 Pages: 1-15

    • DOI

      10.1111/cas.14278

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-19K07379, KAKENHI-PROJECT-19H05649

  • [Journal Article] Inhibitors of the protein?protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line2020
    • Author(s)
      Daisuke Yasuda, Tomoyuki Ohe, Kyoko Takahashi, Riyo Imamura, Hirotatsu Kojima, Takayoshi Okabe, Yoshinobu Ichimura, Masaaki Komatsu, Masayuki Yamamoto, Tetsuo Nagano, Tadahiko Mashino
    • Journal Title

      Free Radical Research

      Volume: Mar 30 Pages: 1-13

    • DOI

      10.1080/10715762.2020.1732955

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K16322, KAKENHI-PLANNED-19H05706, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02611, KAKENHI-PROJECT-18K19417

  • [Journal Article] NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer2020
    • Author(s)
      Baird Liam、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 41 Pages: 1-18

    • DOI

      10.1128/mcb.00473-20

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19K16512

  • [Journal Article] Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium2020
    • Author(s)
      Horiuchi M, Taguchi K, Hirose W, Tsuchida K, Suzuki M, Taniyama Y, Kamei T, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 41

    • DOI

      10.1128/mcb.00536-20

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07395, KAKENHI-PROJECT-19H05649

  • [Journal Article] Nrf2 contributes to the weight gain of mice during space travel.2020
    • Author(s)
      Suzuki, T., et al., Koshiba, S. et al., Yamamoto, M.（合計37名、本研究者は18番目）
    • Journal Title

      Commun Biol.

      Volume: 3 Pages: 496-496

    • DOI

      10.1038/s42003-020-01227-2

    • NAID

      120007161347

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K07298, KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-20K07352, KAKENHI-PROJECT-20K09474, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-20H04832, KAKENHI-WRAPUP-20H05615, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02614, KAKENHI-PROJECT-18H02621

  • [Journal Article] Protracted rosiglitazone treatment exacerbates inflammation in white adipose tissues of adipocyte-specific Nfe2l1 knockout mice2020
    • Author(s)
      Ren Suping、Hou Yongyong、Zuo Zhuo、Liu Zhiyuan、Wang Huihui、Xu Yuanyuan、Yamamoto Masayuki、Zhang Qiang、Fu Jingqi、Pi Jingbo
    • Journal Title

      Food and Chemical Toxicology

      Volume: 146 Pages: 111836-111836

    • DOI

      10.1016/j.fct.2020.111836

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649

  • [Journal Article] Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers.2020
    • Author(s)
      Okazaki Keito、Anzawa Hayato、Liu Zun、Ota Nao、Kitamura Hiroshi、Onodera Yoshiaki、Alam Md. Morshedul、Matsumaru Daisuke、et al.
    • Journal Title

      Nature Communication

      Volume: 11 Pages: 1-19

    • DOI

      10.1038/s41467-020-19593-0

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07361, KAKENHI-PROJECT-19K07379, KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-20K16350, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17K08617

  • [Journal Article] Environmental pollutants and the immune response2020
    • Author(s)
      Suzuki Takafumi、Hidaka Takanori、Kumagai Yoshito、Yamamoto Masayuki
    • Journal Title

      Nature Immunology

      Volume: 21 Pages: 1486-1495

    • DOI

      10.1038/s41590-020-0802-6

    • NAID

      40022683384

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-20K17336, KAKENHI-PROJECT-18H05293, KAKENHI-PROJECT-19H05649

  • [Journal Article] The Molecular Mechanisms Regulating the KEAP1-NRF2 Pathway2020
    • Author(s)
      Baird Liam、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 40 Pages: 1-23

    • DOI

      10.1128/mcb.00099-20

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19K16512

  • [Journal Article] Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice2020
    • Author(s)
      3)(*Equal contribution) Uruno A*, Matsumaru D*, Ryoke R, Saito R, Kadoguchi S, Saigusa D, Saito T, Saido TC, Kawashima R, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 40

    • DOI

      10.1128/mcb.00467-19

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K07361, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-16KK0195

  • [Journal Article] Effects of post-renal anemia treatment with the HIF-PHD inhibitor molidustat on adenine-induced renal anemia and kidney disease in mice2020
    • Author(s)
      Li Lei、Nakano Daisuke、Zhang Anqi、Kittikulsuth Wararat、Morisawa Norihiko、Ohsaki Hiroyuki、Suzuki Norio、Yamamoto Masayuki、Nishiyama Akira
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 144 Pages: 229-236

    • DOI

      10.1016/j.jphs.2020.09.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H03191

  • [Journal Article] Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF22020
    • Author(s)
      Baird Liam、Suzuki Takafumi、Takahashi Yushi、Hishinuma Eiji、Saigusa Daisuke、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 40 Pages: 1-22

    • DOI

      10.1128/mcb.00377-20

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19K16512

  • [Journal Article] Microenvironmental activation of Nrf2 restricts the progression of Nrf2-atcivated malignant tumors.2020
    • Author(s)
      Makiko Hayashi, Ayumi Kuga, Mikiko Suzuki, Harit Panda, Hiroshi Kitamura, Hozumi Motohashi, Masayuki Yamamoto
    • Journal Title

      Cancer Research

      Volume: 0 Pages: 00-00

    • DOI

      10.1158/0008-5472.can-19-2888

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17J04895, KAKENHI-PROJECT-19K07379, KAKENHI-PUBLICLY-20H04832, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02621

  • [Journal Article] Nrf2 Lowers the Risk of Lung Injury via Modulating the Airway Innate Immune Response Induced by Diesel Exhaust in Mice2020
    • Author(s)
      Li YJ, Shimizu T, Shinkai Y, Ihara T, Sugamata T, Kato K, Kobayashi M, Hirata Y, Inagaki H, Uzuki M, Akimoto T, Umezawa M, Takeda K, Azuma A, Yamamoto M, Kawada T.
    • Journal Title

      Biomedicines

      Volume: 8 Pages: 443-443

    • DOI

      10.3390/biomedicines8100443

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K10032, KAKENHI-PROJECT-19H05649

  • [Journal Article] Bardoxolone methyl analog attenuates proteinuria-induced tubular damage by modulating mitochondrial function.2019
    • Author(s)
      Nagasu Hajime、Sogawa Yuji、Kidokoro Kengo、Itano Seiji、Yamamoto Toshiya、Satoh Minoru、Sasaki Tamaki、Suzuki Takafumi、Yamamoto Masayuki、Wigley W. Christian、Proksch Joel W.、Meyer Colin J.、Kashihara Naoki
    • Journal Title

      FASEB J

      Volume: 33 Pages: 12253-12263

    • DOI

      10.1096/fj.201900217r

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18H02828, KAKENHI-PROJECT-18K19417

  • [Journal Article] GATA2 hypomorphism induces chronic myelomonocytic leukemia in mice.2019
    • Author(s)
      Harada Nobuhiko、Hasegawa Atsushi、Hirano Ikuo、Yamamoto Masayuki、Shimizu Ritsuko
    • Journal Title

      Cancer Sci.

      Volume: 110 Pages: 1183-1193

    • DOI

      10.1111/cas.13959

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507

  • [Journal Article] Role of Nrf2 in inflammatory response in lung of mice exposed to zinc oxide nanoparticles2019
    • Author(s)
      Sehsah Radwa、Wu Wenting、Ichihara Sahoko、Hashimoto Naozumi、Hasegawa Yoshinori、Zong Cai、Itoh Ken、Yamamoto Masayuki、Elsayed Ahmed Ali、El-Bestar Soheir、Kamel Emily、Ichihara Gaku
    • Journal Title

      Particle and Fibre Toxicology

      Volume: 16 Pages: 47-47

    • DOI

      10.1186/s12989-019-0328-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H04279, KAKENHI-PROJECT-18K19417

  • [Journal Article] Molecular Mechanism of Cellular Oxidative Stress Sensing by Keap12019
    • Author(s)
      Suzuki Takafumi、Muramatsu Aki、Saito Ryota、Iso Tatsuro、Shibata Takahiro、Kuwata Keiko、Kawaguchi Shin-ichi、Iwawaki Takao、Adachi Saki、Suda Hiromi、Morita Masanobu、Uchida Koji、Baird Liam、Yamamoto Masayuki
    • Journal Title

      Cell Rep

      Volume: 28 Pages: 746-758

    • DOI

      10.1016/j.celrep.2019.06.047

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19K07340, KAKENHI-PROJECT-19K07341, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-19H00990, KAKENHI-PROJECT-19H01019, KAKENHI-PROJECT-18H02366, KAKENHI-PROJECT-18K19417, KAKENHI-ORGANIZER-15H05935, KAKENHI-PROJECT-17H06170

  • [Journal Article] Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response2019
    • Author(s)
      Nagashima Ryuichi、Kosai Hitomi、Masuo Masahiro、Izumiyama Keiko、Noshikawaji Taketo、Morimoto Motoko、Kumaki Satoru、Miyazaki Yasunari、Motohashi Hozumi、Yamamoto Masayuki、Tanaka Nobuyuki
    • Journal Title

      The Journal of Immunology

      Volume: 202 Pages: 1331-1339

    • DOI

      10.4049/jimmunol.1801180

    • NAID

      40022064970

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-16K09576, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-17K16287, KAKENHI-PUBLICLY-18H04794, KAKENHI-PROJECT-18H02621

  • [Journal Article] Generation and molecular characterization of human ring sideroblasts: A key role of ferrous iron in erythroid differentiation and ring sideroblast formation2019
    • Author(s)
      Saito K, Fujiwara T, Hatta S, Morita M, Ono K, Suzuki C, Fukuhara N, Onishi Y, Nakamura Y, Kawamata S, Shimizu R, Yamamoto M, Harigae H.
    • Journal Title

      Mol Cell Biol

      Volume: 39

    • DOI

      10.1128/mcb.00387-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-18K08314, KAKENHI-PROJECT-17H04668

  • [Journal Article] Direct and Specific Functional Evaluation of the Nrf2 and MafG Heterodimer by Introducing a Tethered Dimer into Small Maf-Deficient Cells2019
    • Author(s)
      Katsuoka Fumiki、Otsuki Akihito、Takahashi Mizue、Ito Shin、Yamamoto Masayuki
    • Journal Title

      Molecular and Cellular Biology

      Volume: 39

    • DOI

      10.1128/mcb.00273-19

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08617, KAKENHI-PROJECT-19K16511, KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K19417

  • [Journal Article] Nrf2 represses the onset of type 1 diabetes in non-obese diabetic mice2019
    • Author(s)
      Yagishita Y, Uruno A, Chartoumpekis DV, Kensler TW, Yamamoto M.
    • Journal Title

      Journal of Endocrinology

      Volume: 未定 Pages: 403-416

    • DOI

      10.1530/joe-18-0355

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-18K19417, KAKENHI-PLANNED-26111002

  • [Journal Article] Dietary supplementation with sulforaphane attenuates liver damage and heme overload in a sickle cell disease murine model2019
    • Author(s)
      Panda Harit、Keleku-Lukwete Nadine、Kuga Ayumi、Fuke Nobuo、Suganuma Hiroyuki、Suzuki Mikiko、Yamamoto Masayuki
    • Journal Title

      Experimental Hematology

      Volume: 77

    • DOI

      10.1016/j.exphem.2019.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H05649, KAKENHI-PROJECT-18K19417

  • [Journal Article] Nrf2 Activation Ameliorates Hepatotoxicity Induced by a Heme Synthesis Inhibitor.2019
    • Author(s)
      Taguchi Keiko、Masui Saho、Itoh Tohru、Miyajima Atsushi、Yamamoto Masayuki
    • Journal Title

      Toxicological Sciences

      Volume: 167 Pages: 227-238

    • DOI

      10.1093/toxsci/kfy233

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PUBLICLY-17H05497, KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic2019
    • Author(s)
      Liu Zhiyuan、Hou Yongyong、Li Lu、Yang Yang、Jia Jingkun、Hong Zhixuan、Li Tingfeng、Xu Yuanyuan、Fu Jingqi、Sun Yongxin、Yamamoto Masayuki、Wang Huihui、Pi Jingbo
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 367 Pages: 62-70

    • DOI

      10.1016/j.taap.2019.02.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-18K19417

  • [Journal Article] Sulforaphane enriched transcriptome of lung mitochondrial energy metabolism and provided pulmonary injury protection via Nrf2 in mice2019
    • Author(s)
      Cho Hye-Youn、Miller-DeGraff Laura、Blankenship-Paris Terry、Wang Xuting、Bell Douglas A.、Lih Fred、Deterding Leesa、Panduri Vijayalakshmi、Morgan Daniel L.、Yamamoto Masayuki、Reddy Anita J.、Talalay Paul、Kleeberger Steven R.
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 364 Pages: 29-44

    • DOI

      10.1016/j.taap.2018.12.004

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417

  • [Journal Article] NFE2-Related Transcription Factor 2 Coordinates Antioxidant Defense with Thyroglobulin Production and Iodination in the Thyroid Gland2018
    • Author(s)
      Ziros PG.、Habeos IG.、Chartoumpekis DV.、Ntalampyra E、Somm E、Renaud CO.、Bongiovanni M、Trougakos IP.、Yamamoto M、Kensler TW.、Santisteban P、Carrasco N、Ris-Stalpers C、Amendola E、Liao XH、Rossich L、Thomasz L、Juvenal GJ.、Refetoff S、Sykiotis GP
    • Journal Title

      Thyroid

      Volume: 28 Pages: 780-798

    • DOI

      10.1089/thy.2018.0018

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PLANNED-26111002

  • [Journal Article] NRF2 mitigates acute alcohol-induced hepatic and pancreatic injury in mice2018
    • Author(s)
      Sun Jing、Fu Jingqi、Zhong Yang、Li Lu、Chen Chengjie、Wang Xiaolei、Wang Linlin、Hou Yongyong、Wang Huihui、Zhao Rui、Zhang Xixuan、Yamamoto Masayuki、Xu Yuanyuan、Pi Jingbo
    • Journal Title

      Food and Chemical Toxicology

      Volume: 121 Pages: 495-503

    • DOI

      10.1016/j.fct.2018.09.042

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417

  • [Journal Article] Phenethyl Isothiocyanate, a Dual Activator of Transcription Factors NRF2 and HSF12018
    • Author(s)
      Dayalan Naidu Sharadha、Suzuki Takafumi、Yamamoto Masayuki、Fahey Jed W.、Dinkova-Kostova Albena T.
    • Journal Title

      Molecular Nutrition & Food Research

      Volume: 62 Pages: 1700908-1700908

    • DOI

      10.1002/mnfr.201700908

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17KK0183, KAKENHI-PROJECT-17K15590

  • [Journal Article] A Gata3 3' Distal Otic Vesicle Enhancer Directs Inner Ear-Specific Gata3 Expression.2018
    • Author(s)
      Moriguchi Takashi、Hoshino Tomofumi、Rao Arvind、Yu Lei、Takai Jun、Uemura Satoshi、Ise Kazue、Nakamura Yasuhiro、Lim Kim-Chew、Shimizu Ritsuko、Yamamoto Masayuki、Engel James Douglas
    • Journal Title

      Mol Cell Biol.

      Volume: 38 Pages: 21-21

    • DOI

      10.1128/mcb.00302-18

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-18H05041, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-15H04759, KAKENHI-PROJECT-16H05147

  • [Journal Article] An Overview of the Advantages of KEAP1-NRF2 System Activation During Inflammatory Disease Treatment2018
    • Author(s)
      Keleku-Lukwete Nadine、Suzuki Mikiko、Yamamoto Masayuki
    • Journal Title

      Antioxid Redox Signal.

      Volume: -

    • DOI

      10.1089/ars.2017.7358

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H06639

  • [Journal Article] KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy2018
    • Author(s)
      Shekh-Ahmad Tawfeeq、Eckel Ramona、Dayalan Naidu Sharadha、Higgins Maureen、Yamamoto Masayuki、Dinkova-Kostova Albena T、Kovac Stjepana、Abramov Andrey Y、Walker Matthew C
    • Journal Title

      Brain

      Volume: 141 Pages: 1390-1403

    • DOI

      10.1093/brain/awy071

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19417

  • [Journal Article] Palmitate deranges erythropoietin production via transcription factor ATF4 activation of unfolded protein response2018
    • Author(s)
      Anusornvongchai Thitinun、Nangaku Masaomi、Jao Tzu-Ming、Wu Chia-Hsien、Ishimoto Yu、Maekawa Hiroshi、Tanaka Tetsuhiro、Shimizu Akira、Yamamoto Masayuki、Suzuki Norio、Sassa Ryoji、Inagi Reiko
    • Journal Title

      Kidney International

      Volume: 94 Pages: 536-550

    • DOI

      10.1016/j.kint.2018.03.011

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K09688, KAKENHI-PROJECT-17K19680, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111003, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-18H02727, KAKENHI-PROJECT-18H02824

  • [Journal Article] Iron attenuates erythropoietin production by decreasing hypoxia-inducible transcription factor 2α concentrations in renal interstitial fibroblasts2018
    • Author(s)
      Suzuki Norio、Matsuo-Tezuka Yukari、Sasaki Yusuke、Sato Koji、Miyauchi Kenichiro、Kato Koichiro、Saito Sakae、Shimonaka Yasushi、Hirata Michinori、Yamamoto Masayuki
    • Journal Title

      Kidney International

      Volume: 94 Pages: 900-911

    • DOI

      10.1016/j.kint.2018.06.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K19680, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691

  • [Journal Article] Deficiency in the transcription factor NRF2 worsens inflammatory parameters in a mouse model with combined tauopathy and amyloidopathy2018
    • Author(s)
      Rojo Ana I.、Pajares Marta、Garcia-Yague Angel J.、Buendia Izaskun、Van Leuven Fred、Yamamoto Masayuki、Lopez Manuela G.、Cuadrado Antonio
    • Journal Title

      Redox Biology

      Volume: 18 Pages: 173-180

    • DOI

      10.1016/j.redox.2018.07.006

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PLANNED-26111002

  • [Journal Article] Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo2018
    • Author(s)
      Yoshida E, Suzuki T, Morita M, Taguchi K, Tsuchida K, Motohashi H, Doita M, and Yamamoto M
    • Journal Title

      Genes to Cells

      Volume: - Pages: 386-392

    • DOI

      10.1111/gtc.12579

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K15590, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-15H02815, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04794, KAKENHI-PUBLICLY-18H04963, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508

  • [Journal Article] Roles of the KEAP1-NRF2 system in mammalian skin exposed to UV radiation2018
    • Author(s)
      Ikehata Hironobu、Yamamoto Masayuki
    • Journal Title

      Toxicology and Applied Pharmacology

      Volume: 360 Pages: 69-77

    • DOI

      10.1016/j.taap.2018.09.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PLANNED-26111002

  • [Journal Article] The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis2018
    • Author(s)
      Yamamoto Masayuki、Kensler Thomas W.、Motohashi Hozumi
    • Journal Title

      Physiological Reviews

      Volume: 98 Pages: 1169-1203

    • DOI

      10.1152/physrev.00023.2017

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PUBLICLY-18H04794, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508

  • [Journal Article] Genetic inactivation of Nrf2 prevents clonal expansion of initiated cells in a nutritional model of rat hepatocarcinogenesis2018
    • Author(s)
      Orru Claudia、Szydlowska Marta、Taguchi Keiko、Zavattari Patrizia、Perra Andrea、Yamamoto Masayuki、Columbano Amedeo
    • Journal Title

      Journal of Hepatology

      Volume: 69 Pages: 635-643

    • DOI

      10.1016/j.jhep.2018.05.010

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15KK0325

  • [Journal Article] Sulforaphane ameliorates steroid insensitivity through an Nrf2-dependent pathway in cigarette smoke-exposed asthmatic mice2018
    • Author(s)
      Sakurai Hirofumi、Morishima Yuko、Ishii Yukio、Yoshida Kazufumi、Nakajima Masayuki、Tsunoda Yoshiya、Hayashi Shih-Yuan、Kiwamoto Takumi、Matsuno Yosuke、Kawaguchi Mio、Yamamoto Masayuki、Hizawa Nobuyuki
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 129 Pages: 473-485

    • DOI

      10.1016/j.freeradbiomed.2018.10.400

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K15454, KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-18H03173, KAKENHI-PROJECT-16K09571

  • [Journal Article] C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape2018
    • Author(s)
      Dayalan Naidu Sharadha、Muramatsu Aki、Saito Ryota、Asami Soichiro、Honda Tadashi、Hosoya Tomonori、Itoh Ken、Yamamoto Masayuki、Suzuki Takafumi、Dinkova-Kostova Albena T.
    • Journal Title

      Sci Rep

      Volume: 8 Pages: 8037-8037

    • DOI

      10.1038/s41598-018-26269-9

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04963, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-17K15590

  • [Journal Article] Quantitative analysis of UV photolesions suggests that cyclobutane pyrimidine dimers produced in mouse skin by UVB are more mutagenic than those produced by UVC.2018
    • Author(s)
      H. Ikehata, T. Mori, T. Douki, J. Cadet, M. Yamamoto
    • Journal Title

      Photochemical and Photobiological Sciences

      Volume: 17 Pages: 404-413

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H02815

  • [Journal Article] Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding2018
    • Author(s)
      Kanamoto Mayu、Tsuchiya Yoshihiro、Nakao Yuki、Suzuki Takafumi、Motohashi Hozumi、Yamamoto Masayuki、Kamata Hideaki
    • Journal Title

      PLoS ONE 13(11) e0203978 2018年

      Volume: 13

    • DOI

      10.1371/journal.pone.0203978

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19417, KAKENHI-PROJECT-17KK0183, KAKENHI-PUBLICLY-18H04794, KAKENHI-PUBLICLY-18H04963, KAKENHI-PROJECT-18H02621, KAKENHI-PROJECT-17F17116, KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-16K18419, KAKENHI-PROJECT-17K15590

  • [Journal Article] Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma2018
    • Author(s)
      Hamada Shin、Shimosegawa Tooru、Taguchi Keiko、Nabeshima Tatsuhide、Yamamoto Masayuki、Masamune Atsushi
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol.

      Volume: 314

    • DOI

      10.1152/ajpgi.00228.2017

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04804

  • [Journal Article] Derepression of the DNA methylation machinery of Gata1 gene triggers the differentiation cue for erythropoiesis.2017
    • Author(s)
      Yu L, Takai J, Otsuki A, Katsuoka F, Suzuki M, Katayama S, Nezu M, Engel JD, Moriguchi T, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 37 Pages: 2272-2281

    • DOI

      10.1128/mcb.00592-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-15H06037, KAKENHI-PROJECT-16H07149, KAKENHI-INTERNATIONAL-15K21759

  • [Journal Article] Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.2017
    • Author(s)
      Nezu Masahiro、Souma Tomokazu、Yu Lei、Sekine Hiroki、Takahashi Nobuyuki、Wei Andrew Zu-Sern、Ito Sadayoshi、Fukamizu Akiyoshi、Zsengeller Zsuzsanna K.、Nakamura Tomohiro、Hozawa Atsushi、Karumanchi S. Ananth、Suzuki Norio、Yamamoto Masayuki
    • Journal Title

      Sci Signal.

      Volume: 10

    • DOI

      10.1126/scisignal.aam5711

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19680, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-17H01519, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-17K08618

  • [Journal Article] Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation.2017
    • Author(s)
      Tsuchida K, Tsujita T, Hayashi M, Ojima A, Keleku-Lukwete N, Katsuoka F, Otsuki A, Kikuchi H, Oshima Y, Suzuki M, Yamamoto M.
    • Journal Title

      Free Radic Biol Med.

      Volume: 103 Pages: 236-247

    • DOI

      10.1016/j.freeradbiomed.2016.12.041

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05922, KAKENHI-PROJECT-16H06639, KAKENHI-PROJECT-16H07149, KAKENHI-PROJECT-26461395

  • [Journal Article] GATA2 haploinsufficiency accelerates EVI1-driven leukemogenesis2017
    • Author(s)
      Katayama Saori、Suzuki Mikiko、Yamaoka Ayaka、Keleku-Lukwete Nadine、Katsuoka Fumiki、Otsuki Akihito、Kure Shigeo、Engel James Douglas、Yamamoto Masayuki
    • Journal Title

      Blood

      Volume: 130 Pages: 908-919

    • DOI

      10.1182/blood-2016-12-756767

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-16H07149

  • [Journal Article] Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus2017
    • Author(s)
      Suzuki T, Seki S, Hiramoto K, Naganuma E, Kobayashi EH, Yamaoka A, Baird L, Takahashi N, Sato H, Yamamoto M.
    • Journal Title

      Nature Communications.

      Volume: 8 Pages: 1-13

    • DOI

      10.1038/ncomms14577

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-15H02815, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-16K19027, KAKENHI-PROJECT-17K15590

  • [Journal Article] Discovery of benzo[g]indoles as a novel class of non-covalent Keap1-Nrf2 protein-protein interaction inhibitor2017
    • Author(s)
      Yasuda Daisuke、Yuasa Akihiro、Obata Rika、Nakajima Mao、Takahashi Kyoko、Ohe Tomoyuki、Ichimura Yoshinobu、Komatsu Masaaki、Yamamoto Masayuki、Imamura Riyo、Kojima Hirotatsu、Okabe Takayoshi、Nagano Tetsuo、Mashino Tadahiko
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 27 Pages: 5006-5009

    • DOI

      10.1016/j.bmcl.2017.10.008

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05137

  • [Journal Article] Regulation of hypoxia-inducible gene expression after HIF activation.2017
    • Author(s)
      Suzuki N, Gradin K, Poellinger L, Yamamoto M.
    • Journal Title

      Exp. Cell Res.

      Volume: 356 Pages: 182-186

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-INTERNATIONAL-15K21759

  • [Journal Article] Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.2017
    • Author(s)
      T. Suzuki, M. Yamamoto
    • Journal Title

      Journal of Biological Chemistry

      Volume: 292 Pages: 16817-16824

    • DOI

      10.1074/jbc.r117.800169

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02815

  • [Journal Article] NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells2017
    • Author(s)
      Murakami S, Suzuki T, Harigae H, Romeo PH, Yamamoto M, Motohashi H
    • Journal Title

      Mol Cell Biol

      Volume: 37

    • DOI

      10.1128/mcb.00086-17

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19508, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-17F17116

  • [Journal Article] The KEAP1-NRF2 system in cancer2017
    • Author(s)
      Taguchi K, Yamamoto M.
    • Journal Title

      Front Oncol

      Volume: 7 Pages: 85-85

    • DOI

      10.3389/fonc.2017.00085

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15KK0325, KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2 improves leptin and insulin resistance provoked by hypothalamic oxidative stress.2017
    • Author(s)
      Yagishita Y, Uruno A, Fukutomi T, Saito R, Saigusa D, Pi J, Fukamizu A, Sugiyama F, Takahashi S, Yamamoto M.
    • Journal Title

      Cell Reports

      Volume: 18 Pages: 2030-2044

    • DOI

      10.1016/j.celrep.2017.01.064

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-16K19046

  • [Journal Article] The novel Nrf2 inducer TFM-735 ameliorates experimental autoimmune encephalomyelitis in mice.2017
    • Author(s)
      Higashi C, Kawaji A, Tsuda N, Hayashi M, Saito R, Yagishita Y, Suzuki T, Uruno A, Nakamura M, Nakao K, Furusako S, Yamamoto M.
    • Journal Title

      European Journal of Pharmacology

      Volume: 802 Pages: 30130-30139

    • DOI

      10.1016/j.ejphar.2017.02.044

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-16K19046, KAKENHI-PROJECT-17K01837, KAKENHI-PROJECT-17K15590

  • [Journal Article] Renal anemia model mouse established by transgenic rescue with erythropoietin gene lacking kidney-specific regulatory element2017
    • Author(s)
      Hirano I, Suzuki N, Yamazaki S, Sekine H, Minegishi N, Shimizu R, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 37

    • DOI

      10.1128/mcb.00451-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-26860625, KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-17K19680

  • [Journal Article] Effects of deficiency of Kelch-like ECH-associated protein 1 on skeletal organization: a mechanism for diminished nuclear factor of activated T cells cytoplasmic 1 during osteoclastogenesis2017
    • Author(s)
      Sakai E., Morita M., Ohuchi M., Kido MA., Fukuma Y., Nishishita K., Okamoto K., Itoh K., Yamamoto M, and Tsukuba T
    • Journal Title

      FASEB J.

      Volume: 31 Pages: 4011-4022

    • DOI

      10.1096/fj.201700177r

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11480, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-15H05298, KAKENHI-PROJECT-17H04379, KAKENHI-PROJECT-16K11510, KAKENHI-PROJECT-16K15790, KAKENHI-PROJECT-25293064

  • [Journal Article] 低酸素ストレスに対する生体応答機構2017
    • Author(s)
      平野育生, 山本雅之
    • Journal Title

      ファルマシア

      Volume: 53 Pages: 201-205

    • NAID

      130005398264

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.2017
    • Author(s)
      Nezu M, Souma T, Yu L, Suzuki T, Saigusa D, Ito S, Suzuki N, Yamamoto M.
    • Journal Title

      Kidney Internatinal.

      Volume: 91 Pages: 387-387

    • DOI

      10.1016/j.kint.2016.08.023

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-17K19680

  • [Journal Article] Regulation of hypoxia-inducible gene expression after HIF activation2017
    • Author(s)
      Suzuki Norio、Gradin Katarina、Poellinger Lorenz、Yamamoto Masayuki
    • Journal Title

      Exp Cell Res

      Volume: 356 Pages: 182-186

    • DOI

      10.1016/j.yexcr.2017.03.013

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19680, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691

  • [Journal Article] Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice.2017
    • Author(s)
      Ano S, Panariti A, Allard B, O'Sullivan M, McGovern TK, Hamamoto Y, Ishii Y, Yamamoto M, Powell WS, Martin JG.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 102 Pages: 1-15

    • DOI

      10.1016/j.freeradbiomed.2016.11.017

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16K15454

  • [Journal Article] Nuclear factor (erythroid derived 2)-like 2 activation increases exercise endurance capacity via redox modulation in skeletal muscles2017
    • Author(s)
      Oh S, Komine S, Warabi E, Akiyama K, Ishii A, Ishige K, Mizokami Y, Kuga K, Horie M, Miwa Y, Iwawaki T, Yamamoto M, Shoda J
    • Journal Title

      Sci Rep.

      Volume: 7 Pages: 12902-12902

    • DOI

      10.1038/s41598-017-12926-y

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19887, KAKENHI-PROJECT-17K19888, KAKENHI-ORGANIZER-15H05935, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-15H04281, KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-17H02174, KAKENHI-PROJECT-16K14589, KAKENHI-PROJECT-16K15188, KAKENHI-PUBLICLY-16H01630

  • [Journal Article] NRF2 deficiency replicates transcriptomic changes in Alzheimer's patients and worsens APP and TAU pathology2017
    • Author(s)
      Rojo Ana I.、Pajares Marta、Rada Patricia、Nunez Angel、Nevado-Holgado Alejo J.、Killik Richard、Van Leuven Fred、Ribe Elena、Lovestone Simon、Yamamoto Masayuki、Cuadrado Antonio
    • Journal Title

      Redox Biol

      Volume: 13 Pages: 444-451

    • DOI

      10.1016/j.redox.2017.07.006

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Verification of WFA-sialylated MUC1 as a sensitive biliary biomarker for human biliary tract cancer.2017
    • Author(s)
      Shoda J, Matsuda A, Shida T, Yamamoto M, Nagino M, Tsuyuguchi T, Yasaka T, Tazuma S, Uchiyama K, Unno M, Ohkohchi N, Nakanuma Y, Kuno A, Narimatsu H.
    • Journal Title

      Journal of Gastroenterology

      Volume: 52 Pages: 218-228

    • DOI

      10.1007/s00535-016-1230-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H03255, KAKENHI-PROJECT-26282191, KAKENHI-PROJECT-26293284, KAKENHI-PROJECT-26293297, KAKENHI-PROJECT-15K15488, KAKENHI-PROJECT-15K10197, KAKENHI-PROJECT-15K21667, KAKENHI-PROJECT-15H04935, KAKENHI-PROJECT-16H05220

  • [Journal Article] Nrf2 promotes mutant K-ras/p53-driven pancreatic carcinogenesis2017
    • Author(s)
      Hamada Shin、Taguchi Keiko、Masamune Atsushi、Yamamoto Masayuki、Shimosegawa Tooru
    • Journal Title

      Carcinogenesis.

      Volume: 38 Pages: 661-670

    • DOI

      10.1093/carcin/bgx043

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04804

  • [Journal Article] Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.2017
    • Author(s)
      Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H
    • Journal Title

      Mol Cell Biol 34,

      Volume: 37

    • DOI

      10.1128/mcb.00063-17

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K19508, KAKENHI-PROJECT-16H06295, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-17F17116

  • [Journal Article] Infiltration of M1, but not M2, macrophages is impaired after unilateral ureter obstruction in Nrf2-deficient mice2017
    • Author(s)
      Sogawa Y, Nagasu H, Iwae S, Ihoriya C, Itano S, Uchida A, Kidokoro K, Taniguchi S, Takahashi M, Satoh M, Sasaki T, Suzuki T, Yamamoto M, Horng T and Kashihara N.
    • Journal Title

      Sci Rep

      Volume: 7 Pages: 8801-8801

    • DOI

      10.1038/s41598-017-08054-2

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K15590, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04838, KAKENHI-PROJECT-15K09146, KAKENHI-PROJECT-16K19501

  • [Journal Article] The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of neurotrophic factor Artemin.2017
    • Author(s)
      Hidaka, T., Ogawa, E., Kobayashi, E.H., Suzuki, T., Funayama, R., Nagashima, T., Fujimura, T., Aiba, S., Nakayama, K., Okuyama, R., Yamamoto, M.
    • Journal Title

      Nature Immunology

      Volume: 18 Pages: 64-73

    • DOI

      10.1038/ni.3614

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-15K08257, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26461686, KAKENHI-PROJECT-16K14664, KAKENHI-PROJECT-16K10143, KAKENHI-PROJECT-17K15590, KAKENHI-PROJECT-17H04240

  • [Journal Article] Role of Keap1-Nrf2 signaling in depression and dietary intake of glucoraphanin confers stress resilience in mice2016
    • Author(s)
      Yao W, Zhang JC, Ishima T, Dong C, Yang C, Ren Q, Ma M, Han M, Wu J, Suganuma H, Ushida Y, Yamamoto M, Hashimoto K.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 30659-30659

    • DOI

      10.1038/srep30659

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016
    • Author(s)
      Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal SS, Yamamoto M.
    • Journal Title

      Mol Cell Biol.

      Volume: 36

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460383

  • [Journal Article] Erythropoietin synthesis in renal myofibroblasts is restored by activation of hypoxia signaling2016
    • Author(s)
      Tomokazu Souma, Masahiro Nezu, Daisuke Nakano, Shun Yamazaki, Ikuo Hirano, Hiroki Sekine, Takashi Dan, Kotaro Takeda, Guo-Hua Fong, Akira Nishiyama, Sadayoshi Ito, Toshio Miyata, Masayuki Yamamoto, Norio Suzuki
    • Journal Title

      J Am Soc Nephrol.

      Volume: 27 Pages: 428-428

    • DOI

      10.1681/asn.2014121184

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25670157, KAKENHI-PROJECT-26860623

  • [Journal Article] The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study2016
    • Author(s)
      Chen Y, Xu Y, Zheng H, Fu J, Hou Y, Wang H, Zhang Q, Yamamoto M, Pi J.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 478 Pages: 87-92

    • DOI

      10.1016/j.bbrc.2016.07.088

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Generation of a new model rat: Nrf2 knockout rats are sensitive to aflatoxin B1 toxicity2016
    • Author(s)
      Taguchi K, Takaku M, Egner PA, Morita M, Kaneko T, Mashimo T, Kensler TW, Yamamoto M.
    • Journal Title

      Toxicol Sci.

      Volume: in press Pages: 40-52

    • DOI

      10.1093/toxsci/kfw065

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460384, KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26290033, KAKENHI-PROJECT-26291005, KAKENHI-PROJECT-15KK0325, KAKENHI-INTERNATIONAL-15K21759

  • [Journal Article] Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.2016
    • Author(s)
      Saito R, Suzuki T, Hiramoto K, Asami S, Naganuma E, Suda H, Iso T, Yamamoto H, Morita M, Baird L, Furusawa Y, Negishi T, Ichinose M, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 36 Pages: 271-284

    • DOI

      10.1128/mcb.00868-15

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460354, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-15H02815

  • [Journal Article] Synthesis of Keap1-phosphorylated p62 and Keap1-Nrf2 protein-protein interaction inhibitors and their inhibitory activity.2016
    • Author(s)
      Yasuda D, Nakajima M, Yuasa A, Obata R, Takahashi K, Ohe T, Ichimura Y, Komatsu M, Yamamoto M, Imamura R, Kojima H, Okabe T, Nagano T, Mashino T.
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 26 Pages: 5956-5959

    • DOI

      10.1016/j.bmcl.2016.10.083

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05137

  • [Journal Article] Unique cistrome defined as CsMBE is strictly required for Nrf2-sMaf heterodimer function in cytoprotection2016
    • Author(s)
      Otsuki A, Suzuki M, Katsuoka F, Tsuchida K, Suda H, Morita M, Shimizu R, Yamamoto M.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 91 Pages: 45-57

    • DOI

      10.1016/j.freeradbiomed.2015.12.005

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K09464, KAKENHI-PROJECT-26461395, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-15J05418, KAKENHI-PROJECT-24591404

  • [Journal Article] p62/Sqstml promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.2016
    • Author(s)
      Saito, T., Ichimura, Y., Taguchi, K., Suzuki, T., Mizushima, T., Takagi, K., Hirose, Y., Nagahashi, M., Iso, T., Fukutomi, T., Ohishi, M., Endo, K., Uemura, T., Nishito, Y., Okuda, S., Obata, M., Kouno, T., Imamura, R., Tada, Y., Obata, R., Yasuda, D., Takahashi, K., Fujimura, T., Pi, J., Lee, M-S., Ueno, T., Ohe, T., Mashino, T., Wakai, T., Kojima, H., Okabe, T., Nagano, T., Motoheshi, H., Waguri, S., Soga, T., Yamamoto, M., Tanaka, K., and Komatsu, M.
    • Journal Title

      Nat Commun.

      Volume: 7 Pages: 12-030

    • DOI

      10.1038/ncomms12030

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01190, KAKENHI-PLANNED-24112009, KAKENHI-PLANNED-25111006, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26242088, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-15H04670, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05137, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-16K15228, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-16K10565, KAKENHI-PROJECT-15KK0325, KAKENHI-PROJECT-26000014

  • [Journal Article] The NRF2-mediated gene regulation and glucose homeostasis.2016
    • Author(s)
      Yagishita Y, Uruno A, and Yamamoto M.
    • Journal Title

      Diabetes and Nutrition

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Gata3 Hypomorphic Mutant Mice Rescued with a Yeast Artificial Chromosome Transgene Suffer a Glomerular Mesangial Cell Defec2016
    • Author(s)
      Moriguchi T, Yu L, Otsuki A, Ainoya K, Lim KC, Yamamoto M, Engel JD.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 36 Pages: 2272-2281

    • DOI

      10.1128/mcb.00173-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-16H07149

  • [Journal Article] Functional links between SQSTM1 and ALS2 in the pathogenesis of ALS: cumulative impact on the protection against mutant SOD1-mediated motor dysfunction in mice2016
    • Author(s)
      Hadano, S., Mitsui, S., Pan, L., Otomo, A., Kubo, M., Sato, K., Ono, S., Onodera, W., Abe, K., Koike, M., Uchiyama, Y., Aoki, M., Warabi, E., Yamamoto, M., Ishii, T., Yanagawa, T., Shang, HF., Yoshii, F
    • Journal Title

      Hum Mol Genet.

      Volume: 25 Pages: 3321-3340

    • DOI

      10.1093/hmg/ddw180

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01388, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-26290018, KAKENHI-PROJECT-26460485

  • [Journal Article] The Mediator subunit MED16 transduces NRF2-activating signals into antioxidant gene expression2016
    • Author(s)
      Sekine H, Okazaki K, Ota N, Shima H, Katoh Y, Suzuki N, Igarashi K, Ito M, Motohashi H, Yamamoto M
    • Journal Title

      Mol. Cell. Biol.

      Volume: 36 Pages: 407-420

    • DOI

      10.1128/mcb.00785-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460677, KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-25460351, KAKENHI-PROJECT-25670157, KAKENHI-PROJECT-26670150

  • [Journal Article] NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth.2016
    • Author(s)
      Satoh H, Moriguchi T, Saigusa D, Baird L, Yu L, Rokutan H, Igarashi K, Ebina M, Shibata T, Yamamoto M.
    • Journal Title

      Cancer Res

      Volume: 76 Pages: 3088-3096

    • DOI

      10.1158/0008-5472.can-15-1584

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16H05147

  • [Journal Article] Roles of renal erythropoietin-producing (REP) cells in the maintenance of systemic oxygen homeostasis2016
    • Author(s)
      Suzuki N, Yamamoto M
    • Journal Title

      Pflugers Arch

      Volume: 468 Pages: 3-12

    • DOI

      10.1007/s00424-015-1740-2

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-INTERNATIONAL-15K21759, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25670157

  • [Journal Article] Nrf2/Keap1 system regulates vascular smooth muscle cell apoptosis for vascular homeostasis: role in neointimal formation after vascular injury.2016
    • Author(s)
      Ashino T, Yamamoto M, Numazawa S.
    • Journal Title

      Sci Rep

      Volume: 6 Pages: 26291-26291

    • DOI

      10.1038/srep26291

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15K07973, KAKENHI-PROJECT-15K19398

  • [Journal Article] Small Maf deficiency recapitulates the liver phenotypes of Nrf1- and Nrf2-deficient mice.2016
    • Author(s)
      Katsuoka F, Yamazaki H, Yamamoto M.
    • Journal Title

      Genes Cells

      Volume: 21 Pages: 1309-1319

    • DOI

      10.1111/gtc.12445

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Absolute amounts and status of Nrf2-Keap1-Cul3 complex within cells2016
    • Author(s)
      Iso T, Suzuki T, Baird L, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 36 Pages: 3100-3112

    • DOI

      10.1128/mcb.00389-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-15H02815, KAKENHI-PROJECT-26460354

  • [Journal Article] Efficacy estimation of erythropoiesis-stimulating agents using erythropoietin-deficiency anemic mice2016
    • Author(s)
      Suzuki N, Sasaki Y, Kato K, Yamazaki S, Kurasawa M, Yorozu K, Shimonaka Y, Yamamoto M.
    • Journal Title

      Haematologica

      Volume: 101 Pages: 356-360

    • DOI

      10.3324/haematol.2015.140814

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04691

  • [Journal Article] Small Maf proteins (MafF, MafG, MafK): History, structure and function2016
    • Author(s)
      Katsuoka F, Yamamoto M.
    • Journal Title

      Gene

      Volume: 586 Pages: 197-205

    • DOI

      10.1016/j.gene.2016.03.058

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription2016
    • Author(s)
      Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M.
    • Journal Title

      Nat Commun.

      Volume: 7 Pages: 11624-11624

    • DOI

      10.1038/ncomms11624

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-16H05147, KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-15K08257, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-15K14414, KAKENHI-PROJECT-16K15228

  • [Journal Article] Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes.2016
    • Author(s)
      Pajares M, Jimenez-Moreno N, Garcia-Yague AJ, Escoll M, de Ceballos ML, Van Leuven F, Rabano A, Yamamoto M, Rojo AI, Cuadrado A.
    • Journal Title

      Autophagy

      Volume: 12 Pages: 1902-1916

    • DOI

      10.1080/15548627.2016.1208889

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016
    • Author(s)
      Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal SS, Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 36 Pages: 1655-1672

    • DOI

      10.1128/mcb.01095-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-16J00431, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-16K19046, KAKENHI-PROJECT-15K16486

  • [Journal Article] Nrf2-mediated regulation of skeletal muscle glycogen metabolism.2016
    • Author(s)
      Uruno A, Yagishita Y, Katsuoka F, Kitajima Y, Nunomiya A, Nagatomi R, Pi J, Biswal S and Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 36

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26893008

  • [Journal Article] Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes2015
    • Author(s)
      Tojo Y, Sekine H, Hirano I, Pan X, Souma T, Tsujita T, Kawaguchi S, Takeda N, Takeda K, Fong GH, Dan T, Ichinose M, Miyata T, Yamamoto M, Suzuki N.
    • Journal Title

      Mol Cell Biol

      Volume: 35 Pages: 2658-2672

    • DOI

      10.1128/mcb.00161-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860623, KAKENHI-PROJECT-26860625, KAKENHI-PLANNED-26111002, KAKENHI-PLANNED-26111003, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25461113, KAKENHI-PROJECT-25670157

  • [Journal Article] In vivo regulation of erythropoiesis by chemically inducible dimerization of the erythropoietin receptor intracellular domain.2015
    • Author(s)
      Suzuki N, Mukai HY, and Yamamoto M.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0119442

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25670157, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702

  • [Journal Article] EPO産生制御機構2015
    • Author(s)
      山本雅之, 鈴木教郎, 祢津昌広
    • Journal Title

      腎と透析

      Volume: 79 Pages: 88-93

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Overexpression and Gene Amplification of HER1, HER2 and HER3 in Biliary Tract Carcinomas and the Possibility for Therapy with a HER2-Targeting Antibody Pertuzumab.2015
    • Author(s)
      Kawamoto T, Thomas M, Yamashita-Kashima Y, Shu S, Ishikura N, Ariizumi S, Yamamoto M, Kurosaki K, Shoda J
    • Journal Title

      J Gastroenterrol

      Volume: 50 Pages: 467-479

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293297

  • [Journal Article] CNC-bZIP Protein Nrf1-Dependent Regulation of Glucose-Stimulated Insulin Secretion.2015
    • Author(s)
      Zheng H, Fu J, Xue P, Zhao R, Dong J, Liu D, Yamamoto M, Tong Q, Teng W, Qu W, Zhang Q, Andersen ME, Pi J.
    • Journal Title

      Antioxid. Redox Signal.

      Volume: 22 Pages: 819-831

    • DOI

      10.1089/ars.2014.6017

    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] LSD1/KDM1A promotes hematopoietic commitment of hemangioblast through downregulation of Etv22015
    • Author(s)
      Takeuchi, M., Fuse, Y., Watanabe, M., Andrea, C.S., Takeuchi, M., Nakajima, H., Ohashi, K., Kaneko, H., Kobayashi-Osaki, M., Yamamoto, M. and Kobayashi, M.
    • Journal Title

      PNAS USA

      Volume: 112 Pages: 13922-13927

    • DOI

      10.1073/pnas.1517326112

    • NAID

      120007135765

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26520101, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116705, KAKENHI-PROJECT-25440007

  • [Journal Article] Whole-body in vivo monitoring of inflammatory diseases exploiting human interleukin 6-luciferase transgenic mice.2015
    • Author(s)
      Hayashi M, Takai J, Yu L, Motohashi H, Moriguchi T, Yamamoto M
    • Journal Title

      Mol Cell Biol.

      Volume: 35 Pages: 3590-3601

    • DOI

      10.1128/mcb.00506-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-26670150

  • [Journal Article] . An integrative approach to analyze microarray datasets for prioritization of genes relevant to lens biology and disease.2015
    • Author(s)
      17.Anand D, Agrawal S, Siddam A, Motohashi H, Yamamoto M, and Lachke SA
    • Journal Title

      Genom Data

      Volume: 5 Pages: 223-227

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] The human GATA1 gene retains a 5' insulator that maintains chromosomal architecture and GATA1 expression levels in splenic erythroblasts.2015
    • Author(s)
      Moriguchi T, Yu L, Takai J, Hayashi M, Satoh H, Suzuki M, Ohneda K, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 35 Pages: 1825-1837

    • DOI

      10.1128/mcb.00011-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590359, KAKENHI-PUBLICLY-25118722, KAKENHI-PROJECT-15K08285, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-26670463

  • [Journal Article] DNA methyltransferase 3a regulates osteoclast differentiation by coupling to an S-adenosylmethionine-producing metabolic pathway2015
    • Author(s)
      Nishikawa et al.
    • Journal Title

      Narure Med.

      Volume: 21 Pages: 281-287

    • DOI

      10.1038/nm.3774

    • NAID

      40020592843

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22113007, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25293423, KAKENHI-PROJECT-25670792, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116719, KAKENHI-PROJECT-26670673, KAKENHI-PROJECT-26713010, KAKENHI-PROJECT-25253070

  • [Journal Article] Inter-Individual Differences in the Oral Bacteriome Are Greater than Intra-Day Fluctuations in Individuals.2015
    • Author(s)
      16.Sato Y, Yamagishi J, Yamashita R, Shinozaki N, Ye B, Yamada T, Yamamoto M, Nagasaki M, and Tsuboi A.
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0131607

    • NAID

      120006473603

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Activation of the NRF2 pathway and its impact on the prognosis of anaplastic glioma patients2015
    • Author(s)
      Kanamori M*, Higa T, Sonoda Y, Murakami S, Dodo M, Kitamura H, Taguchi K, Shibata T, Watanabe M, Suzuki H, Shibahara I, Saito R, Yamashita Y, Kumabe T, Yamamoto M, Motohashi H*, and Tominaga T.
    • Journal Title

      Neuro Oncol.

      Volume: 17 Pages: 555-565

    • DOI

      10.1093/neuonc/nou282

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PUBLICLY-25117703, KAKENHI-PROJECT-25670613, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26860180

  • [Journal Article] Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling.2015
    • Author(s)
      Souma T, Nezu M, Nakano D, Yamazaki S, Hirano I, Sekine H, Dan T, Takeda K, Fong GH, Nishiyama A, Ito S, Miyata T, Yamamoto M, Suzuki N
    • Journal Title

      J. Am. Soc. Nephrol.

      Volume: -

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] The Keap1-Nrf2 system and diabetes mellitus2015
    • Author(s)
      Uruno A, Yagishita Y, Yamamoto M.
    • Journal Title

      Arch Biochem Biophys

      Volume: 566 Pages: 76-84

    • DOI

      10.1016/j.abb.2014.12.012

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26893008, KAKENHI-PLANNED-26111002

  • [Journal Article] Progenitor stage-specific activity of a cis-acting double GATA motif for Gata1 gene expression.2015
    • Author(s)
      Moriguchi T, Suzuki M, Yu L, Takai J, Ohneda K, and Yamamoto M. “
    • Journal Title

      Mol. Cell. Biol.

      Volume: 35 Pages: 805-815

    • DOI

      10.1128/mcb.01011-14

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24591404, KAKENHI-PUBLICLY-25118722, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26461395, KAKENHI-PROJECT-26670463

  • [Journal Article] Identification of a functional antioxidant response element within the eighth intron of the human ABCC3 gene.2015
    • Author(s)
      Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, and Cherrington NJ.
    • Journal Title

      Drug Metab Dispos

      Volume: 43 Pages: 93-99

    • DOI

      10.1124/dmd.114.060103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-26111002

  • [Journal Article] Alcohol dehydrogenase 3 contributes to the protection of liver from nonalcoholic steatohepatitis.2015
    • Author(s)
      Goto M, Kitamura H, Alam MM, Ota N, Haseba T, Akimoto T, Shimizu A, Takano-Yamamoto T, Yamamoto M, Motohashi H.
    • Journal Title

      Genes to Cells

      Volume: - Pages: 464-480

    • DOI

      10.1111/gtc.12237

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860180

  • [Journal Article] The Human GATA1 Gene Retains a 5' Insulator that Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts.2015
    • Author(s)
      Moriguchi T, Yu L, Takai J, Hayashi M, Satoh H, Suzuki M, Ohneda K, Yamamoto M.
    • Journal Title

      Mol. Cell. Biol.

      Volume: -

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-26111002

  • [Journal Article] Molecular basis of the Keap1-Nrf2 system2015
    • Author(s)
      T. Suzuki, M. Yamamoto
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 88 Pages: 93-100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H02815

  • [Journal Article] MAFG Is a Transcriptional Repressor of Bile Acid Synthesis and Metabolism2015
    • Author(s)
      de Aguiar Vallim TQ, Tarling EJ, Ahn H, Hagey LR, Romanoski CE, Lee RG, Graham MJ, Motohashi H, Yamamoto M, Edwards PA.
    • Journal Title

      Cell Metab

      Volume: 21 Pages: 298-310

    • DOI

      10.1016/j.cmet.2015.01.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-26670150, KAKENHI-PLANNED-26111002

  • [Journal Article] Molecular basis of the Keap1-Nrf2 system2015
    • Author(s)
      Suzuki T, Yamamoto M
    • Journal Title

      Free Radic Biol Med

      Volume: 88 Pages: 93-100

    • DOI

      10.1016/j.freeradbiomed.2015.06.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460354, KAKENHI-PLANNED-26111002

  • [Journal Article] Amelioration of inflammation and tissue damage in sickle cell model mice by Nrf2 activation2015
    • Author(s)
      Nadine Keleku-Lukwete, Mikiko Suzuki, Akihito Otsuki, Kouhei Tsuchida, Saori Katayama, Makiko Hayashi, Eriko Naganuma, Takashi Moriguchi, Osamu Tanabe, James Douglas Engel, Masue Imaizumi, Masayuki Yamamoto
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 112 Pages: 12169-12174

    • DOI

      10.1073/pnas.1509158112

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460355, KAKENHI-PROJECT-26461395, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-15H02507, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-26670463

  • [Journal Article] Renal erythropoietin-producing cells in health and disease2015
    • Author(s)
      Souma T, Suzuki N, Yamamoto M
    • Journal Title

      Front Physiol

      Volume: 3 Pages: 167-167

    • DOI

      10.3389/fphys.2015.00167

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26860623, KAKENHI-PLANNED-26111002, KAKENHI-PUBLICLY-26116702, KAKENHI-PROJECT-15H04691, KAKENHI-PROJECT-25670157

  • [Journal Article] In vivo spectrum of UVC-induced mutation in mouse skin epidermis may reflect the cytosine deamination propensity of cyclobutane pyrimidine dimers.2015
    • Author(s)
      H. Ikehata, T. Mori and M. Yamamoto
    • Journal Title

      Photochemistry and Photobiology

      Volume: 91 Pages: 1488-1496

    • DOI

      10.1111/php.12525

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26550042, KAKENHI-PROJECT-15H02815

  • [Journal Article] Hypoxia-Sensitive Reporter System for High-Throughput Screening2015
    • Author(s)
      Tsujita, T.; Kawaguchi, S-i.; Dan, T.; Baird, L.; Miyata, T.; Yamamoto, M.
    • Journal Title

      Tohoku J. Exp. Med.

      Volume: 235 Issue: 2 Pages: 151-159

    • DOI

      10.1620/tjem.235.151

    • NAID

      130004822440

    • ISSN
      0040-8727, 1349-3329
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J05784, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860168

  • [Journal Article] The subcellular localization and activity of cortactin is regulated by acetylation and interaction with Keap1.2015
    • Author(s)
      Ito A, Shimazu T, Maeda S, Shah AA, Tsunoda T, Iemura S, Natsume T, Suzuki T, Motohashi H, Yamamoto M, Yoshida M.
    • Journal Title

      Sci. Signal.

      Volume: 8 Pages: 404-404

    • DOI

      10.1126/scisignal.aad0667

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460354, KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-24115007, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26221204, KAKENHI-PROJECT-15H04692, KAKENHI-PROJECT-26650011, KAKENHI-PROJECT-26670150

  • [Journal Article] Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.2014
    • Author(s)
      Ida T, Sawa T, Ihara H, Tsucr iya Y, Watanabe Y, Kumagai Y, Suematsu M, Motohashi H, Fujii S. Matsunaga T, Yamamoto M, Ono K, Devarie-Baez N O, Xian M, Fukuto J M, Akaike T.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: (印刷中) Pages: 1-6

    • DOI

      10.1073/pnas.1321232111

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-11F01105, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-20117005, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24390082, KAKENHI-PROJECT-24590527, KAKENHI-PROJECT-24790263, KAKENHI-PROJECT-25220103, KAKENHI-PROJECT-25253020, KAKENHI-PROJECT-25430069, KAKENHI-PROJECT-25870549, KAKENHI-ORGANIZER-26111001, KAKENHI-PLANNED-26111008, KAKENHI-PROJECT-26670131, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26670207

  • [Journal Article] Plasticity of renal erythropoietin-producing cells governs fibrosis.2014
    • Author(s)
      Souma T, Yamazaki S, Moriguchi T, Suzuki N, Hirano I, Pan X, Minegishi N, Abe M, Kiyomoto H, Ito S, Yamamoto M
    • Journal Title

      J Am Soc Nephrol.

      Volume: 24 Pages: 1559-1616

    • DOI

      10.1681/asn.2013010030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591187, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25462533, KAKENHI-PROJECT-25670157

  • [Journal Article] GATA2 regulates differentiation of bone marrow-derived mesenchymal stem cells2014
    • Author(s)
      Kamata M, Okitsu Y, Fujiwara T, Kanehira M, Nakajima S, Takahashi T, Inoue A, Fukuhara N, Onishi Y, Ishizawa K, Shimizu R, Yamamoto M, and Harigae H.
    • Journal Title

      Haematologica

      Volume: 11 Pages: 1686-1696

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Nrf2 enhances myocardial clearance of toxic ubiquitinated proteins.2014
    • Author(s)
      Wang W, Li S, Wang H, Li B, Shao L, Lai Y, Horvath G, Wang Q, Yamamoto M, Janicki JS, Wang XL, Tang D, and Cui T.
    • Journal Title

      J Mol Cell Cardiol 72,

      Volume: 72 Pages: 305-315

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis2014
    • Author(s)
      Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, and Yamamoto M.
    • Journal Title

      Cancer Prev Res (Phila)

      Volume: 7 Pages: 835-844

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] IDH2 mutation is frequently observed in giant cell tumor of bone2014
    • Author(s)
      Kato-Kaneko M, Liu X, Oki H, Ogasawara S, Nakamura T, Saidoh N, Tsujimoto Y, Matsuyama Y, Uruno A, Sugawara M, Tsuchiya T, Yamakawa M, Yamamoto M, Takagi M, Kato Y.
    • Journal Title

      Cancer Sci.

      Volume: 105 Pages: 744-748

    • DOI

      10.1111/cas.12413

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25460451, KAKENHI-PROJECT-26460383

  • [Journal Article] Critical role of Nrf2 in oxidative stress-induced retinal ganglion cell death2014
    • Author(s)
      Himori N, Yamamoto K, Maruyama K, Ryu M, Taguchi K, Yamamoto M, Nakazawa T.
    • Journal Title

      J Neurochem

      Volume: 127 Pages: 669-680

    • DOI

      10.1111/jnc.12325

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23592613, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24659756, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-25117703

  • [Journal Article] Transcription factor Nrf1 negatively regulates the cystine/glutamate transporter and lipid-metabolizing enzymes.2014
    • Author(s)
      Tsujita T, Peirce V, Baird L, Matsuyama Y, Takaku M, Walsh SV, Griffin JL, Uruno A, Yamamoto M, and Hayes JD.
    • Journal Title

      Mol Cell Biol.

      Volume: 34 Pages: 3800-3816

    • DOI

      10.1128/mcb.00110-14

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25750357, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460383

  • [Journal Article] Keap1 inhibition attenuates glomerulosclerosis2014
    • Author(s)
      Miyazaki Y, Shimizu A, Pastan I, Taguchi K, Naganuma E, Suzuki T, Hosoya T, Yokoo T, Saito A, Miyata T, Yamamoto M, Matsusaka T.
    • Journal Title

      Ｎｅｐｈｒｏｌ　Ｄｉａｌ　Ｔｒａｎｓｐｌａｎｔ

      Volume: 29 Pages: 783-791

    • DOI

      10.1093/ndt/gfu002

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23591202, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-25112502, KAKENHI-PUBLICLY-25117703, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-26460354, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-26461241

  • [Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder.2014
    • Author(s)
      Onuki K, Sugiyama H, Ishige K, Kawamoto T, Ota T, Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M, Miyoshi E, Shoda J.
    • Journal Title

      J Gastroenterol

      Volume: 49 Pages: 702-714

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293297

  • [Journal Article] Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice2014
    • Author(s)
      Hirotsu Y, Higashi C, Fukutomi T, Katsuoka F, Tsujita T, Yagishita Y, Matsuyama Y, Motohashi H, Uruno A, and Yamamoto M.
    • Journal Title

      Genes Cells.

      Volume: 19 Pages: 650-665

    • DOI

      10.1111/gtc.12165

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25750357, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26670150, KAKENHI-PROJECT-26893008

  • [Journal Article] Possible involvementof nuclear factor erythroid 2-related factor 2 in the gene expression of Cyp2b10and Cyp2a52014
    • Author(s)
      Ashino T, Ohkubo-Morita H, Yamamoto M, Yoshida T, Numazawa S
    • Journal Title

      Redox Biol

      Volume: 10 Pages: 284-288

    • DOI

      10.1016/j.redox.2013.12.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790785

  • [Journal Article] An efficient quantitation method of next-generation sequencing libraries by using MiSeq sequencer.2014
    • Author(s)
      Katsuoka F, Yokozawa J, Tsuda K, Ito S, Pan X, Nagasaki M, Yasuda J, and Yamamoto M.
    • Journal Title

      Anal. Biochem.

      Volume: 466 Pages: 27-29

    • DOI

      10.1016/j.ab.2014.08.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-26111002

  • [Journal Article] Nrf2 induces fibroblast growth factor 21 in diabetic mice.2014
    • Author(s)
      Furusawa Y, Uruno A, Yagishita Y, Higashi C, and Yamamoto M.
    • Journal Title

      Genes Cells.

      Volume: 19 Pages: 864-878

    • DOI

      10.1111/gtc.12186

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26460383, KAKENHI-PROJECT-26893008

  • [Journal Article] A remote GATA2 hematopoietic enhancer drives leukemogenesis in inv(3)(q21;q26) by activating EVI1 expression2014
    • Author(s)
      Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M.
    • Journal Title

      Cancer Cell

      Volume: 25 Pages: 415-27

    • DOI

      10.1016/j.ccr.2014.02.008

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-12J08044, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24790957, KAKENHI-PROJECT-26670463, KAKENHI-PROJECT-26860178

  • [Journal Article] Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by Notch signaling.2014
    • Author(s)
      Wakabayashi N, Skoko JJ, Chartoumpekis DV, Kimura S, Slocum SL, Noda K, Palliyaguru DL, Fujimuro M, Boley PA, Tanaka Y, Shigemura N, Biswal S, Yamamoto M, Kensler TW
    • Journal Title

      Mol. Cell. Biol.

      Volume: 34 Pages: 653-663

    • DOI

      10.1128/mcb.01408-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590103

  • [Journal Article] Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.2014
    • Author(s)
      Murakami S, Shimizu R, Romeo PH, Yamamoto M, Motohashi H.
    • Journal Title

      Gene Cells

      Volume: 19 Pages: 239-253

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659142

  • [Journal Article] Hematopoietic stem and progenitor cell activation during chronic dermatitis provoked by constitutively active aryl-hydrocarbon receptor driven by Keratin14 promoter.2014
    • Author(s)
      Murakami S., Yamamoto M. and Motohashi H
    • Journal Title

      Toxicol Sci

      Volume: 138 Pages: 47-58

    • DOI

      10.1093/toxsci/kft273

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-11J06582, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075

  • [Journal Article] Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population.2014
    • Author(s)
      Motoike IN, Matsumoto M, Danjoh I, Katsuoka F, Kojima K, Nariai N, Sato Y, Yamaguchi-Kabata Y, Ito S, Kudo H, Nishijima I, Nishikawa S, Pan X, Saito R, Saito S, Saito T, Shirota M, Tsuda K, Yokozawa J, Igarashi K, Minegishi N, Tanabe O, Fuse N, Nagasaki M, Kinoshita K, Yasuda J, and Yamamoto M.
    • Journal Title

      BMC Genomics

      Volume: 10 Pages: 637-637

    • DOI

      10.1186/1471-2164-15-673

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25440254, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26461482

  • [Journal Article] Myeloid lineage-specific deletion of antioxidant system enhances tumor metastasis.2014
    • Author(s)
      Hiramoto K, Satoh H, Suzuki T, Moriguchi T, Pi J, Shimosegawa T, Yamamoto M.
    • Journal Title

      Cancer Prev. Res.

      Volume: 7 Pages: 835-844

    • DOI

      10.1158/1940-6207.capr-14-0094

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25112502, KAKENHI-PLANNED-26111010, KAKENHI-PROJECT-26460354

  • [Journal Article] A regulatory network governing Gata1 and Gata2 gene transcription orchestrates erythroid lineage differentiation2014
    • Author(s)
      Moriguchi T, Yamamoto M.
    • Journal Title

      Int J Hematol

      Volume: 100 Pages: 417-424

    • DOI

      10.1007/s12185-014-1568-0

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142

  • [Journal Article] Keap1-Nrf2系と腎臓病2014
    • Author(s)
      祢津昌広・相馬友和・山本雅之
    • Journal Title

      Annual Review腎臓

      Volume: 2014 Pages: 89-96

    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Nrf2 protects pancreatic β-cells from oxidative and nitrosative stress in diabetic model mice.2014
    • Author(s)
      Yagishita Y, Fukutomi T, Sugawara A, Kawamura H, Takahashi T, Pi J, Uruno A, and Yamamoto M.
    • Journal Title

      Deabetes

      Volume: 63 Pages: 605-618

    • DOI

      10.2337/db13-0909

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790306, KAKENHI-PROJECT-23390458

  • [Journal Article] Remarkable induction of UV-signature mutations at the 3’-cytosine of dipyrimidine sites except at 5’-TCG-3’ in the UVB-induced skin epidermis of xeroderma pigmentosum variant model mice.2014
    • Author(s)
      Ikehata H, Chang Y, Yokoi M, Yamamoto M, Hanaoka F
    • Journal Title

      DNA Repair

      Volume: 22 Pages: 112-122

    • DOI

      10.1016/j.dnarep.2014.07.012

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-22131008, KAKENHI-PROJECT-24310036, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26340028

  • [Journal Article] Gata2 regulates differentiation of bone marrow-derived mesenchymal stem cells.2014
    • Author(s)
      Kamata M, Okitsu Y, Fujiwara T, Kanehira M, Nakajima S, Takahashi T, Inoue A, Fukuhara N, Onishi Y, Ishizawa K, Shimizu R, Yamamoto M, Harigae H.
    • Journal Title

      Haematologica

      Volume: 99 Pages: 1686-1696

    • DOI

      10.3324/haematol.2014.105692

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25860776, KAKENHI-PLANNED-26111002, KAKENHI-PROJECT-26860716

  • [Journal Article] Does Nrf2 gene transfer facilitate recovery after contusion spinal cord injury?”2014
    • Author(s)
      Pomeshchik Y, Kidin I, Savchenko E, Rolova T, Yamamoto M, Levonen AL, Yla-Herttuala S, Kanninen K, Malm T, Koistinaho J
    • Journal Title

      Antioxid Redox Signal

      Volume: 20 Pages: 1313-1323

    • DOI

      10.1089/ars.2013.5453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Nrf2 promotes compensatory liver hypertrophy after portal vein branch ligation in mice2014
    • Author(s)
      Shirasaki K, Taguchi K, Unno M, Motohashi H, and Yamamoto M
    • Journal Title

      Hepatology

      Volume: 59 Pages: 2371-2382

    • DOI

      10.1002/hep.27020

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-25117703, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-26670150

  • [Journal Article] Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice2014
    • Author(s)
      Ohneda K, Moriguchi T, Ohmori S, Ishijima Y, Satoh H, Philipsen S, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 34 Pages: 1812-1826

    • DOI

      10.1128/mcb.01524-13

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PUBLICLY-25118722, KAKENHI-PROJECT-25860221

  • [Journal Article] NRF2 immunolocalization in human breast cancer patients as a prognostic factor2014
    • Author(s)
      Onodera Y, Motohashi H, Takagi K, Miki Y, Shibahara Y, Watanabe M, Ishida T, Hirakawa H, Sasano H, Yamamoto M, and Suzuki T.
    • Journal Title

      Endocr Relat Cancer

      Volume: 21 Pages: 241-252

    • DOI

      10.1530/erc-13-0234

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075

  • [Journal Article] The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis2014
    • Author(s)
      Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, Sagami A, Taguchi K, Bechtold D, Loudon A, Yamamoto M, Chan J, van der Horst GTJ, Fukada Y, and Meng Q-J.
    • Journal Title

      Genes and Development

      Volume: 28 Pages: 548-548

    • DOI

      10.1101/gad.237081.113

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-25112504, KAKENHI-PUBLICLY-25117703, KAKENHI-PROJECT-25440041, KAKENHI-PROJECT-26460384, KAKENHI-PROJECT-24227001

  • [Journal Article] Proteasome dysfunction activates autophagy and the Keap1-Nrf2 pathway.2014
    • Author(s)
      Kageyama S, Sou YS, Uemura T, Kametaka S, Saito T, Ishimura R, Kouno T, Bedford L, Mayer RJ, Lee MS, Yamamoto M, Waguri S, Tanaka K, and Komatsu M.
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 289 Pages: 24944-24955

    • DOI

      10.1074/jbc.m114.580357

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-25111006, KAKENHI-PROJECT-26000014, KAKENHI-PROJECT-26253019, KAKENHI-PROJECT-26830080, KAKENHI-PROJECT-26860224

  • [Journal Article] Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis2014
    • Author(s)
      Cazanave SC, Wang X, Zhou H, Rahmani M, Grant S, Durrant DE, Klaassen CD, Yamamoto M, and Sanyal AJ.
    • Journal Title

      Cell Death Differ

      Volume: 21 Pages: 1303-1312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Kinetic, Thermodynamic and Structural Characterizations of Association between Nrf2-DLGex Degron and Keap12014
    • Author(s)
      Fukutomi, T., Takagi, K., Mizushima, T., Ohuchi, N., and Yamamoto, M.
    • Journal Title

      Molecular Cell Biology

      Volume: 34 Pages: 832-846

    • DOI

      10.1128/mcb.01191-13

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-25870631

  • [Journal Article] Nrf2 enhances cholangiocyte expansion in Pten-deficient livers2014
    • Author(s)
      Taguchi K, Hirano I, Itoh T, Tanaka M, Miyajima A, Suzuki A, Motohashi H, and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 34 Pages: 900-913

    • DOI

      10.1128/mcb.01384-13

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22118006, KAKENHI-PLANNED-23116002, KAKENHI-PUBLICLY-24116508, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-25117703, KAKENHI-PROJECT-25670187, KAKENHI-PROJECT-26460384

  • [Journal Article] GATA2 regulates body-water homeostasis through maintaining Aquaporin 2 expression in renal collecting ducts.2014
    • Author(s)
      Yu L, Moriguchi T, Souma T, Takai J, Satoh H, Morito N, Engel JD, Yamamoto M
    • Journal Title

      Mol Cell Biol.

      Volume: 8 Pages: 1929-1941

    • DOI

      10.1128/mcb.01659-13

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-12J07924, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24591223, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-26860623

  • [Journal Article] Nuclear factor erythroid 2-related factor 2 regulates toll-like receptor 4 innate responses in mouse liver ischemia-reperfusion injury through Akt-forkhead box protein O1 signaling network.2014
    • Author(s)
      Huang J, Yue S, Ke B, Zhu J, Shen XD, Zhai Y, Yamamoto M, Busuttil RW, and Kupiec-Weglinski JW.
    • Journal Title

      Transplantation

      Volume: 98 Pages: 721-728

    • DOI

      10.1097/tp.0000000000000316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-26111002

  • [Journal Article] Naturally occurring oncogenic GATA1 mutants with internal deletions in transient abnormal myelopoiesis in Down syndrome.2014
    • Author(s)
      Toki T, Kanezaki R, Kobayashi E, Kaneko H, Suzuki M, Wang R, Terui K, Kanegane H, Maeda M, Endo M, Mizuochi T, Adachi S, Hayashi Y, Yamamoto M, Shimizu R, Ito E.
    • Journal Title

      Blood

      Volume: 121(16) Pages: 3181-3184

    • DOI

      10.1182/blood-2012-01-405746

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390288, KAKENHI-PROJECT-22591171, KAKENHI-PROJECT-22659196, KAKENHI-PROJECT-23390266, KAKENHI-PROJECT-23390273, KAKENHI-PROJECT-23591560, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390268, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24790957, KAKENHI-PROJECT-25461611, KAKENHI-PROJECT-25670482, KAKENHI-PUBLICLY-23118501

  • [Journal Article] Keap1-Nrf2 system regulates cell fate determination of hematopoietic stem cells.2014
    • Author(s)
      Murakami S., Shimizu R., Romeo P. H., Yamamoto M. Motohashi H.
    • Journal Title

      Gene Cells

      Volume: 19 Pages: 239-253

    • DOI

      10.1111/gtc.12126

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-11J06582, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] PGC-1 Coactivator Activity is Required for Murine Erythropoiesis2014
    • Author(s)
      Cui S, Tanabe O, Lim K-C, Xu HE, Zhou XE, Lin JD, Shi L, Shimizu R, Schmidt L, Campbell A, Yamamoto M, and Engel JD,
    • Journal Title

      Mol Cell Biol

      Volume: 34 Pages: 1956-1965

    • DOI

      10.1128/mcb.00247-14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] The absence of macrophage Nrf2 promotes early atherogenesis2013
    • Author(s)
      Ruotsalainen AK, Inkala M, Partanen ME, Lappalainen JP, Kansanen E, Makinen PI, Heinonen SE, Laitinen HM, Heikkila, Vatanen T, Horkko S, Yamamoto M, Yla-Herttuala S, Jauhiainen M, Levonen AL
    • Journal Title

      Cardiovasc Res

      Volume: 98 Pages: 107-115

    • DOI

      10.1093/cvr/cvt008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy2013
    • Author(s)
      Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
    • Journal Title

      Molecular Cell

      Volume: 51 Pages: 618-31

    • DOI

      10.1016/j.molcel.2013.08.003

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-23247034, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790332, KAKENHI-PROJECT-24790967, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25118710, KAKENHI-PROJECT-25460400, KAKENHI-PROJECT-25870631

  • [Journal Article] Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration2013
    • Author(s)
      Holmstrom KM, Baird L, Zhang Y, Hargreaves I, Chalasani A, Land JM, Stanyer L, Yamamoto M, Dinkova-Kostova AT, Abramov AY
    • Journal Title

      Biol Open

      Volume: 2 Pages: 761-770

    • DOI

      10.1242/bio.20134853

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] 4-Hydroxy hexenal derived from docosahexaenoic acid protects endothelial cells via Nrf2 activation.2013
    • Author(s)
      Ishikado A, Morino K, Nishio Y, Nakagawa F, Mukose A, Sono Y, Yoshioka N, Kondo K, Sekine O, Yoshizaki T, Ugi S, Uzu T, Kawai H, Makino T, Okamura T, Yamamoto M, Kashiwagi A, Maegawa H
    • Journal Title

      PLoS One.

      Volume: 8

    • DOI

      10.1371/journal.pone.0069415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591350

  • [Journal Article] Verification of the in vivo activity of three distinct cis-acting elements within the Gata1 gene promoter-proximal enhancer in mice2013
    • Author(s)
      Shimizu R, Hasegawa A, Ottolenghi S, Ronchi A, Yamamoto M.
    • Journal Title

      Gene Cells

      Volume: 18(11) Pages: 1032-1041

    • DOI

      10.1111/gtc.12096

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J07201, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] The nuclear factor erythroid 2-related factor 2 activator oltipraz attenuates chronic hypoxia-induced cardiopulmonary alterations in mice2013
    • Author(s)
      Eba S, Hoshikawa Y, Moriguchi T, Mitsuishi Y, Satoh H, Ishida K, Watanabe T, Shimizu T, Shimokawa H, Okada Y, Yamamoto M, Kondo T
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: 49 Pages: 324-333

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Establishment of erythroleukemic GAK14 cells and characterization of GATA1 N-terminal domain.2013
    • Author(s)
      Mukai HY, Suzuki M, Nagano M, Ohmori S, Otsuki A, Tsuchida K, Moriguchi T, Ohneda K, Shimizu R, Ohneda O, Yamamoto M,
    • Journal Title

      Gene Cells

      Volume: 18 Pages: 886-898

    • DOI

      10.1111/gtc.12084

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24790735, KAKENHI-PROJECT-24790957, KAKENHI-PUBLICLY-25118722, KAKENHI-PROJECT-25860221

  • [Journal Article] Keap1-Nrf2 complex in ischemia-induced hepatocellular damage of mouse liver transplants2013
    • Author(s)
      Ke B, Shen XD, Zhang Y, Ji H, Gao F, Yue S, Kamo N, Zhai Y, Yamamoto M, Busuttil RW, Kupiec-Weglinski JW
    • Journal Title

      J Hepatol

      Volume: 59 Pages: 1200-1207

    • DOI

      10.1016/j.jhep.2013.07.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Loss of a Rho-Regulated Actin Nucleator, mDia2, Impairs Cytokinesis during Mouse Fetal Erythropoiesis2013
    • Author(s)
      Watanabe S, De Zan T, Ishizalki T, Yasuda S, Kamijo H, Yamada D, Aoki T, Kiyonari H, Kaneko H, Shimizu R, Yamamoto M, Goshima G, and, Narummiya S
    • Journal Title

      Cell Report

      Volume: 5(4) Pages: 926-932

    • DOI

      10.1016/j.celrep.2013.10.021

    • NAID

      120005347116

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J04389, KAKENHI-PROJECT-23229003, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PUBLICLY-25121714

  • [Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress- induced liver injury in nutritional steatohepatitis.2013
    • Author(s)
      Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
    • Journal Title

      J Gastroenterol.

      Volume: (印刷中) Pages: 924-935

    • DOI

      10.1007/s00535-012-0552-9

    • NAID

      10031051379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PLANNED-20117010, KAKENHI-PROJECT-22300260, KAKENHI-PROJECT-22500656, KAKENHI-PROJECT-22590802, KAKENHI-PROJECT-22790127, KAKENHI-PROJECT-23300250, KAKENHI-PROJECT-23660033, KAKENHI-PROJECT-24650436, KAKENHI-PROJECT-24659104, KAKENHI-PROJECT-24659122, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-23117503

  • [Journal Article] Erythropoietin production in neuroepithelial and euralcrest cells during primitive erythropoiesis2013
    • Author(s)
      Suzuki N, Hirano I, Pan X, Minegishi N, Yamamoto M
    • Journal Title

      Nature Commun

      Volume: 4 Pages: 2902-2902

    • DOI

      10.1038/ncomms3902

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25670157

  • [Journal Article] 酸化ストレス応答の新展開2013
    • Author(s)
      福富俊明、山本雅之
    • Journal Title

      医学のあゆみ

      Volume: 247 Pages: 731-736

    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] The Keap1-Nrf2 system prevents onset of diabetes mellitus.2013
    • Author(s)
      Uruno A, Furusawa Y, Yagishita Y, Fukutomi T, Muramatsu H, Negishi T, Sugawara A, Kensler TW, Yamamoto M
    • Journal Title

      Molecular and Cellular Biology

      Volume: 33 Pages: 2996-3010

    • DOI

      10.1128/mcb.00225-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790306

  • [Journal Article] Nrf2 prevents initiation but accelerates progression through the Kras signaling pathway during lung carcinogenesis2013
    • Author(s)
      Satoh H, Moriguchi T, Takai J, Ebina M, Yamamoto M
    • Journal Title

      Cancer Res

      Volume: 73 Pages: 4158-4168

    • DOI

      10.1158/0008-5472.can-12-4499

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation.2013
    • Author(s)
      Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
    • Journal Title

      Cancer Prev Res

      Volume: 53 Pages: 149-159

    • DOI

      10.1016/j.freeradbiomed.2012.10.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117010, KAKENHI-PROJECT-23790319, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591223, KAKENHI-PROJECT-24659122, KAKENHI-PROJECT-24790305

  • [Journal Article] A mouse model of adult-onset anaemia due to erythropoietin deficiency.2013
    • Author(s)
      Yamazaki S, Souma T, Hirano I, Pan X, Minegishi N, Suzuki N, Yamamoto M
    • Journal Title

      Nature Commun

      Volume: 4 Pages: 1950-1950

    • DOI

      10.1038/ncomms2950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07924, KAKENHI-PUBLICLY-24116502, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24591404, KAKENHI-PROJECT-25670157

  • [Journal Article] Regulatory nexus of synthesis and degradation deciphers cellular Nrf2 expression levels2013
    • Author(s)
      Suzuki T, Shibata T, Takaya K, Shiraishi K, Kohno T, Kunitoh H, Tsuta K, Furuta K, Goto K, Hosoda F, Sakamoto H, Motohashi H and Yamamoto M.
    • Journal Title

      Molecular and Cellular Biology.

      Volume: 33 Pages: 2402-2412

    • DOI

      10.1128/mcb.00065-13

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790340, KAKENHI-PUBLICLY-25112502

  • [Journal Article] The role of the Nrf2-mediated defense system in corneal epithelial wound healing.2013
    • Author(s)
      Hayashi R, Himori N, Taguchi K, Ishikawa Y, Uesugi K, Ito M, Duncan T, Tsujikawa M, Nakazawa T, Yamamoto M, Nishida K
    • Journal Title

      Free Radic Biol Med.

      Volume: 61C Pages: 333-342

    • DOI

      10.1016/j.freeradbiomed.2013.04.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790307, KAKENHI-PUBLICLY-25117703, KAKENHI-PROJECT-25670731

  • [Journal Article] Erythropoietin contributes to slow oxidative muscle fiber specification via PGC-1a and AMPK activation.2013
    • Author(s)
      Wang L, Jia Y, Rogers H, Suzuki N, Gassmann M, Wang Q, McPherron AC, Kopp J, Yamamoto M, Noguchi CT
    • Journal Title

      Int J Biochem Cell Biol

      Volume: 45 Pages: 1155-1164

    • DOI

      10.1016/j.biocel.2013.03.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PUBLICLY-24116502

  • [Journal Article] Adipose deficiency of Nrf2 in ob/ob mice results in severe metabolic syndrome2013
    • Author(s)
      Xue P, Hou Y, Chen Y, Yang B, Fu J, Zheng H, Yarborough K, Woods CG, Liu D, Yamamoto M, Zhang Q, Andersen ME, Pi J
    • Journal Title

      Diabetes

      Volume: 62 Pages: 845-854

    • DOI

      10.2337/db12-0584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Transforming Growth Factor-β Induces transcription factors MafK and Bach1 to Suppress Expression of the Heme Oxygenase-1 Gene.2013
    • Author(s)
      Okita Y, Kamoshida A, Suzuki H, Itoh K, Motohashi H, Igarashi K, Ogami T, Koinuma D, Kato M.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 288 Pages: 20658-20667

    • DOI

      10.1074/jbc.m113.450478

    • NAID

      120007136878

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PLANNED-23116003, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390066, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-25293092, KAKENHI-PROJECT-25460472, KAKENHI-PROJECT-25640059

  • [Journal Article] Redox-Sensitive Transcription Factor Nrf2 Regulates Vascular Smooth Muscle Cell Migration and Neointimal Hyperplasia.2013
    • Author(s)
      Ashino T, Yamamoto M, Yoshida T, Numazawa S
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 33 Pages: 760-768

    • DOI

      10.1161/atvbaha.112.300614

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590143, KAKENHI-PROJECT-23659068, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24790785

  • [Journal Article] The Gata1 5' region harbors distinct cis-regulatory modules that direct gene activation in erythroid cells and gene inactivation in HSCs2013
    • Author(s)
      Takai J, Moriguchi T, Suzuki M, Yu L, Ohneda K, and Yamamoto M.
    • Journal Title

      Blood

      Volume: 122 Pages: 3450-3460

    • DOI

      10.1182/blood-2013-01-476911

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06534, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24790957, KAKENHI-PUBLICLY-25118722

  • [Journal Article] NF-E2 p45 is important for establishing normal function of platelets2013
    • Author(s)
      Fujita R, Takayama-Tsujimoto M, Satoh H, Gutiérrez L, Aburatani H, Fujii S, Sarai A, Bresnick EH, Yamamoto M*, and Motohashi H* (* corresponding authors)
    • Journal Title

      Mol Cell Biol

      Volume: 33 Pages: 2659-2670

    • DOI

      10.1128/mcb.01274-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24659142

  • [Journal Article] Bigas Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling2013
    • Author(s)
      Guiu J, Shimizu R. D'Altri T,Fraser ST, Hatakeyama J, Bresnick EH, Kageyama R, Dzierzak E, Yamamoto M, Espinosa L, Bigas A.
    • Journal Title

      J Exp Med

      Volume: 210(1) Pages: 71-84

    • DOI

      10.1084/jem.20120993

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390288, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] Nrf2 deficiency leads to behavioral, neurochemical and transcriptional changes in mice2013
    • Author(s)
      Muramatsu H, Katsuoka F, Toide K, Shimizu Y, Furusako S, Yamamoto M
    • Journal Title

      Genes Cells

      Volume: 18 Pages: 899-908

    • DOI

      10.1111/gtc.12083

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding2013
    • Author(s)
      More VR, Xu J, Shimpi PC, Belgrave C, Luyendyk JP, Yamamoto M, Slitt AL
    • Journal Title

      Free Radic Biol Med

      Volume: 61C Pages: 85-94

    • DOI

      10.1016/j.freeradbiomed.2013.03.007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] GATA factor switching from GATA2 to GATA1 contributes to erythroid differentiation.2013
    • Author(s)
      Suzuki M, Kobayashi-Osaki M, Tsutsumi S, Pan X, Ohmori S, Takai J, Moriguchi T, Ohneda O, Ohneda K, Shimizu R, Kanki Y, Kodama T, Aburatani H, Yamamoto M
    • Journal Title

      Genes to Cells

      Volume: 18 Pages: 921-33

    • DOI

      10.1111/gtc.12086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24590359, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24710227, KAKENHI-PROJECT-24790957, KAKENHI-PUBLICLY-25118709, KAKENHI-PUBLICLY-25118722, KAKENHI-PUBLICLY-25125707, KAKENHI-PROJECT-25440007, KAKENHI-PROJECT-25860221

  • [Journal Article] Roles of Keap1-Nrf2 system in upper aerodigestive tract carcinogenesis2013
    • Author(s)
      Ohkoshi A, Suzuki T, Ono M, Kobayashi T, Yamamoto M
    • Journal Title

      Cancer Prev Res

      Volume: 6 Pages: 149-159

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Disruption of the Hbsl1-Myb locus causes hereditary persistence of fetal hemoglobin in mouse.2013
    • Author(s)
      Suzuki M, Yamazaki H, Mukai HY, Motohashi H, Shi L, Tanabe 0, Engel JD, Yamamoto M.
    • Journal Title

      Mol Cel lBiol

      Volume: 33 Pages: 1687-1695

    • DOI

      10.1128/mcb.01617-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J08044, KAKENHI-PLANNED-23116002, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790957

  • [Journal Article] Mature erythrocyte membrane homeostasis is compromised by lass of the GATA1-FOG1 interaction2012
    • Author(s)
      Hasegawa A, Shimizu R, Mohandas N, Yamamoto M
    • Journal Title

      Blood

      Volume: 11 Pages: 2615-2623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] がん細胞におけるKeap1-Nrf2システムの破綻2012
    • Author(s)
      藤田理恵，本橋ほづみ，山本雅之
    • Journal Title

      実験医学

      Volume: 30 Pages: 2814-2821

    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Pathophysiological regulation of cellular stress response by Keap1-Nrf2 system2012
    • Author(s)
      Yamamoto M
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 52 Pages: 861-861

    • NAID

      130004505186

    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks.2012
    • Author(s)
      Hirotsu Y, Katsuoka F, Funayama R, Nagashima T, Nishida Y, Nakayama K, Engel JD, Yamamoto M.
    • Journal Title

      Nucleic Acids Res

      Volume: 40 Pages: 10228-10239

    • DOI

      10.1093/nar/gks827

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07842, KAKENHI-PROJECT-23790351, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24700951

  • [Journal Article] Heme and heme biosynthesis intermediates induce Heme oxygenase-1 and Cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: Different requirement for transcription factor Nuclear factor erythroid-derived 2-like 22012
    • Author(s)
      Lämsä V, Levonen AL, Sormunen R, Yamamoto M, Hakkola J
    • Journal Title

      Toxicol Sci

      Volume: 130 Pages: 132-144

    • DOI

      10.1093/toxsci/kfs237

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Targeted deletion of Nrf2 impairs lung development and oxidant injury in neonatal mice2012
    • Author(s)
      Cho HY, van Houten B, Wang X, Miller-Degraff L, Fostel J, Gladwell W, Perrow L, Panduri V, Kobzik L, Yamamoto M, Bell DA, and Kleeberger SR
    • Journal Title

      Antioxid Redox Signal

      Volume: 17 Pages: 1066-1082

    • DOI

      10.1089/ars.2011.4288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Genetic evidence of an evolutionarily conserved role for Nrf2 in the protection against oxidative stress2012
    • Author(s)
      Mukaigasa K, Nguyen LT, Li L, Nakajima H, Yamamoto M, and Kobayashi M
    • Journal Title

      Mol Cell Biol

      Volume: 32 Pages: 4455-4461

    • DOI

      10.1128/mcb.00481-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] The contribution of GATA1 dysfunction to multi-step leukemogenesis2012
    • Author(s)
      Shimizu R, Yamamoto M
    • Journal Title

      Cancer Sci

      Volume: 103(12) Pages: 2039-2044

    • DOI

      10.1111/cas.12007

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390288, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] p62/SQSTM1Accumulation is associated with poor prognosis of lung adenocarcinomapatients2012
    • Author(s)
      Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M
    • Journal Title

      Cancer Sci.

      Volume: 103 Pages: 760-6

    • DOI

      10.1111/j.1349-7006.2012.02216.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22390163, KAKENHI-PROJECT-23592521, KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-24300326, KAKENHI-PROJECT-24591184, KAKENHI-PROJECT-24592613, KAKENHI-PROJECT-24790306, KAKENHI-PLANNED-23116002

  • [Journal Article] Highly Potent Activation of Nrf2 by Topical Tricyclic Bis (Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy2012
    • Author(s)
      Kalra S, Knatko EV, Zhang Y, Honda T, Yamamoto M, and Dinkova-Kostova AT
    • Journal Title

      Cancer Prev Res

      Volume: 5 Pages: 973-981

    • DOI

      10.1158/1940-6207.capr-12-0041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] The regulation of GATA factor expression is distinct between erythroid and mast cell lineages2012
    • Author(s)
      Ohmori S, Takai J, Ishijima Y, Suzuki M, Moriguchi T, Philipsen S, Yamamoto M, and Ohneda K
    • Journal Title

      Mol Cell Biol

      Volume: 32(23) Pages: 4742-4755

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659142

  • [Journal Article] Accumulation of p62/SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma2012
    • Author(s)
      Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S, Sugawara S, Watanabe M, Sakurada A, Endo C, Uruno A, Sasano H, Nakagawa T, Satoh K, Tanaka N, Kubo H, Motohashi H, Yamamoto M
    • Journal Title

      Cancer Sci

      Volume: 103(4) Pages: 760-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22890014

  • [Journal Article] N- and C-terminal transactivation domains of GATA1 protein coordinate hematopoietic program2012
    • Author(s)
      Kaneko H, Kobayashi E, Yamamoto M, Shimizu R
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 287(25) Pages: 21439-21449

    • DOI

      10.1074/jbc.m112.370437

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390288, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456, KAKENHI-PROJECT-24890015

  • [Journal Article] Embryonic lethality and fetal liver apoptosis in mice lacking all three small mafproteins2012
    • Author(s)
      Yamazaki H, Katsuoka F, Motohashi H, Engel JD, Yamamoto M
    • Journal Title

      Mol. Cell. Biol

      Volume: 32 Pages: 808-816

    • DOI

      10.1128/mcb.06543-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21390074, KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-23790351

  • [Journal Article] Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2/Keap1 pathway in the developing mouse esophagus2012
    • Author(s)
      Chen H, Li J, Li H, Hu Y, Tevebaugh W, Yamamoto M, Que J, and Chen X
    • Journal Title

      PLoS One

      Volume: 7

    • DOI

      10.1371/journal.pone.0036504

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming2012
    • Author(s)
      Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M*, and Motohashi H*.
    • Journal Title

      Cancer Cell

      Volume: 22 Pages: 66-79

    • DOI

      10.1016/j.ccr.2012.05.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-24221011, KAKENHI-PROJECT-24249015, KAKENHI-PLANNED-23116002, KAKENHI-PUBLICLY-23117503

  • [Journal Article] Nuclearfactorerythroid-derivedfactor2-relatedfactor2regulatestranscription of CCAAT/enhancer-bindingprotein β during adipogenesis2012
    • Author(s)
      Hou Y, Xue P, Bai Y, Liu D, Woods CG, Yarborough K, Fu J, Zhang Q, Sun G, Collins S, Chan JY, Yamamoto M, Andersen ME, Pi J
    • Journal Title

      Free Radic Biol Med

      Volume: 52 Pages: 462-473

    • DOI

      10.1016/j.freeradbiomed.2011.10.453

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming2012
    • Author(s)
      Mitsuishi Y, Taguchi K, Kawatani Y, Shibata T, Nukiwa T, Aburatani H, Yamamoto M and Motohashi H
    • Journal Title

      Cancer Cell

      Volume: (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] UG4 enhancer-driven GATA-2 and BMP4 complementation remedies the CAKUT phenotype in Gata2 hypomorphic mutant mice2012
    • Author(s)
      Ainoya K, Moriguchi T, Ohmori S, Souma T, Takai J, Morita M, Chandler KJ, Mortlock DP, Shimizu R, Engel JD, Lim KC, Yamamoto M.
    • Journal Title

      Mol Cell Biol.

      Volume: 32 Pages: 2312-2322

    • DOI

      10.1128/mcb.06699-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07924, KAKENHI-PROJECT-21390288, KAKENHI-PROJECT-24590371, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics2012
    • Author(s)
      Abdullah A, Kitteringham NR, Jenkins RE, Goldring C, Higgins L, Yamamoto M, Hayes J, and Park BK
    • Journal Title

      Pharmacol Rep

      Volume: 64 Pages: 680-697

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism2012
    • Author(s)
      Mitsuishi Y, Motohashi H*, and Yamamoto M*
    • Journal Title

      Front Oncol

      Volume: 2 Pages: 200-200

    • DOI

      10.3389/fonc.2012.00200

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PLANNED-23116002

  • [Journal Article] Targeting Nrf2-mediated gene transcription by extremely potent synthetic triterpenoids attenuates dopaminergic neurotoxicity in the MPTP- mouse model of Parkinson's disease2012
    • Author(s)
      Kaidery NA, Banerjee R, Yang L, Smirnova NA, Hushpulian DM, Liby KT, Williams CR, Yamamoto M, Kensler TW, Ratan RR, Sporn MB, Beal MF, Gazaryan IG, and Thomas B
    • Journal Title

      Antioxid Redox Signal

      Volume: 18 Pages: 139-157

    • DOI

      10.1089/ars.2011.4491

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] Keap1 degradation by autophagy for the maintenance of redox homeostasis.2012
    • Author(s)
      Taguchi K, Fujikawa N, Komatsu M, Ishii T, Unno M, Akaike T, Motohashi H, and Yamamoto M
    • Journal Title

      Proc Natl Acad Sci U S A

      Volume: 109 Pages: 13561-13566

    • DOI

      10.1073/pnas.1121572109

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-20117005, KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PROJECT-24790307, KAKENHI-ORGANIZER-20117001, KAKENHI-PLANNED-23116002, KAKENHI-PUBLICLY-23117503

  • [Journal Article] Mature erythrocyte membrane homeostasis is compromised by loss of the GATA1-FOG1 interaction2012
    • Author(s)
      Hasegawa A, Shimizu R, Mohandas N, Yamamoto M.
    • Journal Title

      Blood

      Volume: 119 Pages: 2615-2623

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Validation of the multiple sensor mechanism of the Keap1-Nrf2 system2012
    • Author(s)
      Takaya K, Suzuki T, Motohashi H, Onodera K, Satomi S, Kensler TW and Yamamoto M.
    • Journal Title

      Free Radical Biology and Medicine

      Volume: 53 Pages: 817-827

    • DOI

      10.1016/j.freeradbiomed.2012.06.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659166, KAKENHI-PROJECT-24249015, KAKENHI-PROJECT-24390075, KAKENHI-PUBLICLY-23112502, KAKENHI-PLANNED-23116002

  • [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia2012
    • Author(s)
      Hasegawa A, Shimizu R, Mohandas N, Yamamoto M
    • Journal Title

      Blood

      Volume: 119(11) Pages: 2615-23

    • DOI

      10.1182/blood-2011-09-382473

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21390288, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-24659142, KAKENHI-PROJECT-24659456

  • [Journal Article] Nrf2 in bone marrow-derived cells positively contributes to the advanced stage of atherosclerotic plaque formation2012
    • Author(s)
      Harada N, Ito K, Hosoya T, Mimura J, Maruyama A, Noguchi N, Yagami KI, Morito N, Takahashi S, Maher JM, Yamamoto M, Itoh K
    • Journal Title

      Free Radic Biol Med

      Volume: 53 Pages: 2256-2262

    • DOI

      10.1158/1940-6207.capr-12-0401-t

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249015

  • [Journal Article] NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1β genes2012
    • Author(s)
      Hirotsu Y, Hataya N, Katsuoka F, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 32 Pages: 2760-2770

    • DOI

      10.1128/mcb.06706-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07842, KAKENHI-PROJECT-23790351, KAKENHI-PROJECT-24249015

  • [Journal Article] Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.2012
    • Author(s)
      Xue M, Rabbani N, Momiji H, Imbasi P, Anwar MM, Kitteringham N, Park BK, Souma T, Moriguchi T, Yamamoto M, Thornalley PJ.
    • Journal Title

      Biochem J

      Volume: 443 Pages: 213-222

    • DOI

      10.1042/bj20111648

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-12J07924, KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22590260, KAKENHI-PROJECT-24590371

  • [Journal Article] Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis2012
    • Author(s)
      Okada K, Warabi E, Sugimoto H, Horie M, Tokushige K, Ueda T, Harada N, Taguchi K, Hashimoto E, Itoh K, Ishii T, Utsunomiya H, Yamamoto M, Shoda J
    • Journal Title

      J Gastroenterol

      Volume: (In press)

    • NAID

      10031051379

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300275

  • [Journal Article] Isolation and Characterization of renal erythropoietin-producing cells from genetically produced anemia mice2011
    • Author(s)
      Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, Yamamoto M
    • Journal Title

      PLoS One

      Volume: 6 Pages: 25839-25839

    • DOI

      10.1371/journal.pone.0025839

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-10J06108, KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591216, KAKENHI-PLANNED-22118002

  • [Journal Article] Constitutive activation of nuclear factor-E2-related factor 2 induces biot ransformation enzyme and transporter expression in livers of mice with hepatocyte-specific deletion of Kelch-like ECH-associated protein 12011
    • Author(s)
      Cheng Q, Taguchi K, Aleksunes LM, Manautou JE, Cherrington NJ, Yamamoto M, Slitt AL
    • Journal Title

      J.Biochem.Mol.Toxicol.

      Volume: 25 Pages: 320-329

    • DOI

      10.1002/jbt.20392

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22790127, KAKENHI-PUBLICLY-23117503

  • [Journal Article] Discovery of the negative regulator of Nrf2, Keapl: A historical overview.2011
    • Author(s)
      Itch K, Mimura J, Yamamoto M.
    • Journal Title

      Antioxid Redox Signal

      Volume: 13 Pages: 1665-1678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice2011
    • Author(s)
      Clarke JD, Hsu A, Williams DE, Dashwood RH, Stevens JF, Yamamoto M, Ho E
    • Journal Title

      Pharm Res

      Volume: 28 Pages: 3171-3179

    • DOI

      10.1007/s11095-011-0500-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 degron-fused reporter system ; a new tool for specific evaluation of Nrf2 inducers.2011
    • Author(s)
      Yosuke Hirotsu, Fumiki Katsuoka, Ken Itoh, Masayuki Yamamoto.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 406-415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Protein aggregation, not polyubiquitin conjugation, serves as a signal forselective autophagy.2011
    • Author(s)
      Riley BE, Kaiser SE, Shaler TA, Ham T, Hipp MS, Sofos E, Ng ACY, Lage K, Xavier RJ, Ryu K-Y, Yamamoto M, Ishii T, Tanaka K, Mizushima N, Komatsu M, Kopito RR.
    • Journal Title

      J Cell Biol

      Volume: 191 Pages: 537-552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Nrf2 degron-fused reporter system : a new tool for specific evaluation of Nrf2 inducers2011
    • Author(s)
      Hirotsu Y, Katsuoka F, Itoh K, and Yamamoto M
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 406-415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia.2011
    • Author(s)
      Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M.
    • Journal Title

      Blood

      Volume: 117 Pages: 986-996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Differential Modulation of Keratin Expression by Sulforaphane Occurs via Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia2011
    • Author(s)
      Kerns M, Depianto D, Yamamoto M, Coulombe PA
    • Journal Title

      Mol Biol Cell

      Volume: 23 Pages: 4068-4057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Role of Nrf2 in Host Defense against Influenza in Cigarette Smoke-Exposed Mice2011
    • Author(s)
      Yageta Y, Ishii Y, Morishima Y, Masuko H, Ano S, Yamadori T, Itoh K, Takeuchi K, Yamamoto M, Hizawa N
    • Journal Title

      J Virology

      Volume: 85 Pages: 4679-4690

    • DOI

      10.1128/jvi.02456-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PLANNED-20117010

  • [Journal Article] Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia.2011
    • Author(s)
      Kerns M, Depianto D, YamamotoM, Coulombe PA.
    • Journal Title

      Mol Biol Cell

      Volume: 23 Pages: 4068-4057

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells2011
    • Author(s)
      Inami Y, Waguri S, Sakamoto A, Kouno T, Nakada K, Hino O, Watanabe S, Ando J, Iwadate M, Yamamoto M, Lee MS, Tanaka K, Komatsu M
    • Journal Title

      Journal of Cell Biology

      Volume: 193 Pages: 275-284

    • DOI

      10.1083/jcb.201102031

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21390234, KAKENHI-PROJECT-21659045, KAKENHI-PROJECT-22650091

  • [Journal Article] Possible Involvement of Oxidative Stress in 5-Fluorouracil-Mediated Myelosuppression in Mice2011
    • Author(s)
      Numazawa S, Sugihara K, Miyake S, Tomiyama H, Hida A, Hatsuno M, Yamamoto M, Yoshida T
    • Journal Title

      Basic Clin Pharmacol Toxicol

      Volume: 108 Pages: 40-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia2011
    • Author(s)
      Kawatani Y, Suzuki T, Shimizu R, Kelly V, Yamamoto M.
    • Journal Title

      Blood

      Volume: 177 Pages: 986-996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes2011
    • Author(s)
      Mimura J, Kosaka K, Maruyama A, Satoh T, Harada N, Yoshida H, Satoh K, Yamamoto M, and Itoh K.
    • Journal Title

      J Biochem

      Volume: 150 Pages: 209-217

    • NAID

      10030587033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Possible involvement of oxidative stress in 5-fluorouracil-mediated myelosuppression in mice2011
    • Author(s)
      Numazawa S, Sugihara K, Miyake S, Tomiyama H, Hida A, Hatsuno M, Yamamoto M, Yoshida T
    • Journal Title

      Basic Clin Pharmacol Toxicol

      Volume: 108 Pages: 40-45

    • DOI

      10.1111/j.1742-7843.2010.00621.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22590143

  • [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia2011
    • Author(s)
      Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M
    • Journal Title

      Blood

      Volume: 117 Pages: 986-996

    • DOI

      10.1182/blood-2010-05-285817

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591216

  • [Journal Article] Luminal alkalization attenuates superoxide production induced by fatty acid-bound albumin in renal proximal tubular cells through Pyk2-dependent pathways2011
    • Author(s)
      Souma T, Abe M, Moriguchi T, Yanagisawa-Miyazawa N, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S
    • Journal Title

      J Am Soc Nephrol

      Volume: (未定)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Acceleration of UVB-induced photoageing in nrf2 gene-deficient mice2011
    • Author(s)
      Hirota A, Kawachi Y, Yamamoto M, Koga T, Hamada K, Otsuka F
    • Journal Title

      Exp Dermatol

      Volume: 20 Pages: 664-668

    • DOI

      10.1111/j.1600-0625.2011.01292.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591454

  • [Journal Article] Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice2011
    • Author(s)
      Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K-i, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M
    • Journal Title

      Journal of Clinical Investigation

      Volume: 121 Pages: 3981-3990

    • DOI

      10.1172/jci57301

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591027, KAKENHI-PROJECT-21591216, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-22600011

  • [Journal Article] Specific contribution of the Erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stage2011
    • Author(s)
      Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, and Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 3896-3905

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Association of Keap1 and Nrf2 Genetic Mutations and Polymorphisms With Endometrioid Endometrial Adenocarcinoma Survival2011
    • Author(s)
      Wong TF, Yoshinaga K, Monma Y, Ito K, Niikura H, Nagase S, Yamamoto M, Yaegashi N
    • Journal Title

      Int J Gynecol Cancer

      Volume: 21 Pages: 1428-1435

    • DOI

      10.1097/igc.0b013e31822d0eb2

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21592119, KAKENHI-PROJECT-23592431

  • [Journal Article] Molecular determinants for small Maf protein control of platelet production2011
    • Author(s)
      Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 151-162

    • DOI

      10.1128/mcb.00798-10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Acute erythropoietin cardioprotection is mediated by endothelial response2011
    • Author(s)
      Teng R, Calvert JW, Sibmooh N, Piknova B, Suzuki N, Sun J, Martinez K, Yamamoto M, Schechter AN, Lefer DJ, Noguchi CT
    • Journal Title

      Basic Res Cardiol

      Volume: 106 Pages: 343-354

    • DOI

      10.1007/s00395-011-0158-z

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia2011
    • Author(s)
      Kawatani Y, Suzuki T, Shimizu R, Kelly V, Yamamoto M
    • Journal Title

      Blood

      Volume: 117 Pages: 986-996

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Discovery of the negative regulator of Nrf2, Keap1 : A historical overview2011
    • Author(s)
      Itoh K, Mimura J, Yamamoto M
    • Journal Title

      Antioxid Redox Signal

      Volume: 13 Pages: 1665-1678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Inducible disruption of autophagy in the lung causes airway hyper-responsivenes2011
    • Author(s)
      Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M
    • Journal Title

      Biochem BiophysRes Commun

      Volume: 405 Pages: 13-18

    • DOI

      10.1016/j.bbrc.2010.12.092

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591216, KAKENHI-PROJECT-22390163

  • [Journal Article] Electrophilic nitro-fatty acids activate NRF2 by a KEAP1 Cysteine 151-independent mechanism2011
    • Author(s)
      Kansanen E, Bonacci G, Schopfer FJ, Kuosmanen SM, Tong KI, Leinonen H, Woodcock SR, Yamamoto M, Carlberg C, Yla-Herttuala S, Freeman BA, Levonen AL
    • Journal Title

      J Biol Chem

      Volume: 286 Pages: 14019-14027

    • DOI

      10.1074/jbc.m110.190710

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nitro-fatty acidsand cyclopentenone prostaglandins sharestrategies to activate the Keap1-Nrf2system : a study using green fluorescentprotein transgenic zebrafish2011
    • Author(s)
      Tsujita T, Li L, Nakajima H, Iwamoto N, Nakajima-Takagi Y, Ohashi K, Kawakami K, Kumagai Y, Freeman BA, Yamamoto M, Kobayashi M
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 46-57

    • DOI

      10.1111/j.1365-2443.2010.01466.x

    • NAID

      120007130821

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21659043

  • [Journal Article] CD36 participates in a signaling pathway that regulates ROS formation in murine VSMC2011
    • Author(s)
      Li W, Febbraio M, Reddy SP, Yu D-Y, Yamamoto M, Silverstein RL
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 3996-4006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Possible Involvement of Oxidative Stress in 5-Fluorouracil-Mediated Myelosuppression in Mice.2011
    • Author(s)
      Numazawa S, Sugihara K, Miyake S, Tomiyama H, Hida A, HatsunoM, Yamamoto M, Yoshida T.
    • Journal Title

      Basic Clin Pharmacol Toxicol.

      Volume: 108 Pages: 40-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells2011
    • Author(s)
      Sugiyama, H., Onuki, K., Ishige, K., Baba, N., Ueda, T., Matsuda, S., Takeuchi, K., Onodera, M., Nakanuma, Y., Yamato, M., Yamamoto, M., Hyodo, I., Shoda, J
    • Journal Title

      J Gastroenterol

      Volume: 46 Pages: 779-789

    • NAID

      10029029679

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300275

  • [Journal Article] Luminal alkalization attenuates superoxide production induced by fattyacid-bound albumin in renal proximal tubular cells through Pyk2-dependent pathways.2011
    • Author(s)
      Souma T, Abe M, Moriguchi T, Yanagisawa-MiyazawaN, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S.
    • Journal Title

      J Am See Nephrol

      Volume: 22 Pages: 635-648

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction2011
    • Author(s)
      Kobayashi A, Tsukide T, Miyasaka T, Morita T, Mizoroki T, Saito Y, Ihara Y, Takashima A, Noguchi N, Fukamizu A, Hirotsu Y, Ohtsuji M, Katsuoka F, Yamamoto M
    • Journal Title

      Genes to Cells

      Volume: 16 Pages: 692-703

    • DOI

      10.1111/j.1365-2443.2011.01522.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22590277

  • [Journal Article] CD36 participates in a signaling pathway that regulates ROS formation inmurine VSMC.2011
    • Author(s)
      Li W, Febbraio M, Reddy SP, Yu D-Y, Yamamoto M, Silverstein RL.
    • Journal Title

      J Clin Invest

      Volume: 120 Pages: 3996-4006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Protein aggregation, not polyubiquitin conjugation, serves as a signal for selective autophagy2011
    • Author(s)
      Riley BE, Kaiser SE, Shaler TA, Hara T, Hipp MS, Sofos E, Ng ACY, Lage K, Xavier RJ, Ryu K-Y, Yamamoto M, Ishii T, Tanaka K, Mizushima N, Komatsu M, Kopito RR
    • Journal Title

      J Cell Biol

      Volume: 191 Pages: 537-552

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Disrupted erythropoietin signaling promotes obesity and alters hypothalamus proopiomelanocortin production2011
    • Author(s)
      Teng R, Gavrilova O, Suzuki N, Chanturiya T, Schimel D, Hugendubler L, Mammen S, Yver DR, Cushman SW, Mueller E, Yamamoto M, Hsu LL, Noguchi CT
    • Journal Title

      Nature Commun

      Volume: 2

    • DOI

      10.1038/ncomms1526

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Up-regulation of p27kip1 contributes to Nrf2-mediated protection against angiotensin II-induced cardiac hypertrophy2011
    • Author(s)
      Li J, Zhang C, Xing Y, Janicki JS, Yamamoto M, Wang XL, Tang DQ, Cui T
    • Journal Title

      Cardiovasc Res

      Volume: 90 Pages: 315-324

    • DOI

      10.1093/cvr/cvr010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution2011
    • Author(s)
      Taguchi K, Motohashi H, Yamamoto M
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 123-140

    • DOI

      10.1111/j.1365-2443.2010.01473.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Itoh K. Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal humanastrocytes. J. Biochem2011
    • Author(s)
      Mimura J, Kosaka K, Maruyama A, Satoh T, Harada N, Yoshida H, Satoh K, Yamamoto M, Itoh K
    • Journal Title

      Tokyo

      Volume: 150 Pages: 209-217

    • DOI

      10.1093/jb/mvr065

    • NAID

      10030587033

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PLANNED-20117010, KAKENHI-PROJECT-22790304, KAKENHI-PROJECT-23592081, KAKENHI-PROJECT-23790319

  • [Journal Article] Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms2011
    • Author(s)
      Tsuchiya Y, Morita T, Kim M, Iemura SI, Natsume T, Yamamoto M, Kobayashi A
    • Journal Title

      Molecular and Cellular Biology

      Volume: 31 Pages: 4500-12

    • DOI

      10.1128/mcb.05663-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22590277, KAKENHI-PROJECT-22790329

  • [Journal Article] Molecular determinants for small Maf protein control of platelet production.2011
    • Author(s)
      Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M.Molecular determinants for small Maf protein control of platelet production.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 151-162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice2011
    • Author(s)
      Asada N, Takase M, Nakamura J, Oguchi A, Asada M, Suzuki N, Yamamura K, Nagoshi N, Shibata S, Rao TN, Fehling HJ, Fukatsu A, Minegishi N, Kita T, Kimura T, Okano H, Yamamoto M, Yanagita M.
    • Journal Title

      J Clin Invest

      Volume: 121 Pages: 3980-3981

    • NAID

      120003338854

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Transcription factor Nrf2 maintains the basa1 expression of Mdm2 : An implication of the regulation of p53 signaling by Nrf22011
    • Author(s)
      You A, Nam CW, Wakabayashi N, Yamamoto M, Kensler TW, Kwak MK
    • Journal Title

      Arch Biochem Biophys

      Volume: 507 Pages: 356-364

    • DOI

      10.1016/j.abb.2010.12.034

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction2011
    • Author(s)
      Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto
    • Journal Title

      Genes Cells

      Volume: (未定)(印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Dual regulation of the transcriptional activity of Nrf1 by { beta}-TrCP-and Hrd1-dependent degradation mechanisms2011
    • Author(s)
      Tsuchiya Y, Morita T, Kim M, Iemura SI, Natsume T, Yamamoto M, and Kobayashi A.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 4500-4512

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis2011
    • Author(s)
      Freigang S, Ampenberger F, Spohn G, Heer S, Shamshiev AT, Kisielow J, Hersberger M, Yamamoto M, Bachmann MF, Kopf M
    • Journal Title

      Eur J Immunol

      Volume: 41 Pages: 2040-2051

    • DOI

      10.1002/eji.201041316

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Hirotsu Y, Katsuoka F, Itoh K, and Yamamoto M. Nrf2 degron-fused reporter system : a new tool for specific evaluation of Nrf2 inducers2011
    • Author(s)
      Hirotsu Y, Katsuoka F, Itoh K, and Yamamoto M.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 406-415

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] Targeted deletion of Nrf2 reduces urethane-induced lung tumor development in mice2011
    • Author(s)
      Bauer AK, Cho HY, Miller-Degraff L, Walker C, Helms K, Fostel J, Yamamoto M, Kleeberger SR
    • Journal Title

      PLoS One

      Volume: 6

    • DOI

      10.1371/journal.pone.0026590

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo2011
    • Author(s)
      Suzuki T, Maher JM, and Yamamoto M
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 1700-1709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keapl-Nrf2 system : study using GFP transgenic zebrafish.2011
    • Author(s)
      Tsujita T, Li L, Nakajima H, Nakajima-Takagi Y, Kawakami K, Freeman B, Yamamoto M, Kobayashi M.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 46-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system : study using GFP transgenic zebrafish2011
    • Author(s)
      Tsujita T, Li L, Nakajima H, Nakajima-Takagi Y, Kawakami K, Freeman B, Yamamoto M, Kobayashi M
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 46-57

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Inducible disruption of autophagy in the lung causes airway hyper-responsiveness.2011
    • Author(s)
      Inoue D, Kubo H, Taguchi K, Suzuki T, Komatsu M, Motohashi H, Yamamoto M.
    • Journal Title

      Biochem Biophys Res Common

      Volume: 405 Pages: 13-18

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury2011
    • Author(s)
      Toyama T, Shinkai Y, Yasutake A, Uchida K, Yamamoto M, Kumagai Y
    • Journal Title

      Environmental Health Perspectives

      Volume: 119 Pages: 1117-1122

    • DOI

      10.1289/ehp.1003123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22790128

  • [Journal Article] Protective role of Nrf2 inage-related hearing loss and gentamicin ototoxicity2011
    • Author(s)
      Hoshino T, Tabuchi K, Nishimura B, Tanaka S, Nakayama M, Ishii T, Warabi E, Yanagawa T, Shimizu R, Yamamoto M, Hara A
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 415 Pages: 94-98

    • DOI

      10.1016/j.bbrc.2011.10.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21390288

  • [Journal Article] Nrf2 degron-fused reporter system: a new tool for specific evaluation of Nrf2 inducers2011
    • Author(s)
      Hirotsu Y, Katsuoka F, Itoh K, Yamamoto M
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 406-415

    • DOI

      10.1111/j.1365-2443.2011.01496.x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PLANNED-20117010

  • [Journal Article] Tissue-restricted induction of Nrf2 andits target genes in zebrafish withgene-specific variations in theinduction profiles2011
    • Author(s)
      Nakajima H, Nakajima-Takagi Y, Tsujita T, Akiyama S, Wakasa T, Mukaigasa K, Kaneko H, Tamaru Y, Yamamoto M, Kobayashi M
    • Journal Title

      PLoS ONE

      Volume: 6

    • DOI

      10.1371/journal.pone.0026884

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21659043

  • [Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction.2011
    • Author(s)
      Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto.
    • Journal Title

      Genes Cells

      Volume: 印刷中(未定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages2011
    • Author(s)
      Kuhn AM, Tzieply N, Schmidt MV, von Knethen A, Namgaladze D, Yamamoto M, Brane B
    • Journal Title

      Free Radic Biol Med

      Volume: 50 Pages: 1382-1391

    • DOI

      10.1016/j.freeradbiomed.2011.02.036

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Molecular mechanisms of the Keapl-Nrf2 pathway in stress response and cancer evolution.2011
    • Author(s)
      Taguchi K, Motohashi H, Yamamoto M.
    • Journal Title

      Genes Cells

      Volume: 16 Pages: 123-140

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Isolation and Characterization of renal erythropoietin-producing cells from genetically produced anemia mice2011
    • Author(s)
      Pan X, Suzuki N, Hirano I, Yamazaki S, Minegishi N, and Yamamoto M
    • Journal Title

      PLos One

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 regulates ferroportin 1-mediated iron efflux and counteracts lipopolysaccharide-induced ferroportin 1 mRNA suppression in macrophages2011
    • Author(s)
      Harada N, Kanayama M, Maruyama A, Yoshida A, Tazumi K, Hosoya T, Mimura J, Toki T, Maher JM, Yamamoto M, Itoh K
    • Journal Title

      Arch. Biochem. Biophys

      Volume: 508 Pages: 101-109

    • DOI

      10.1016/j.abb.2011.02.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PLANNED-20117010, KAKENHI-PROJECT-23790319

  • [Journal Article] The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice2011
    • Author(s)
      Tatsumi, K., Yamamoto-Mukai, H., Shimizu, R., Waguri, S., Sou, Y-S., Sakamoto, A., Taya, C., Shitara, H., Hara, T., Chung, C.H., Tanana, K., Yamamoto, M., Komatsu, M.
    • Journal Title

      Nat Commun 2 Article number

      Volume: 2 Pages: 181-181

    • DOI

      10.1038/ncomms1182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21390288, KAKENHI-PROJECT-23659167

  • [Journal Article] Specific Contribution of the erythropoietin gene 3 enhancer to hepatic erythropoiesis after late embryonic stages2011
    • Author(s)
      Suzuki N, Obara N, Pan X, Watanabe M, Jishage K-i, Minegishi N, Yamamoto M
    • Journal Title

      Molecular cell biology

      Volume: 31 Pages: 3896-3905

    • DOI

      10.1128/mcb.05463-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-21591216, KAKENHI-PLANNED-22118002, KAKENHI-PROJECT-22790895

  • [Journal Article] Initial response and cellular protection through the Keap1/Nrf2 system during exposure of primary mouse hepatocytes to 1,2-naphthoquinone2011
    • Author(s)
      Miura T, Shinkai Y, Jiang HY, Iwamoto N, Sumi D, Taguchi K, Yamamoto M, Jinno H, Tanaka-Kagawa T, Cho AK, Kumagai Y
    • Journal Title

      Chem.Res.Toxicol.

      Volume: 24 Pages: 559-567

    • DOI

      10.1021/tx100427p

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312, KAKENHI-PROJECT-22406004, KAKENHI-PROJECT-22790127, KAKENHI-PUBLICLY-23117503

  • [Journal Article] The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice2011
    • Author(s)
      Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou Y-S, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M
    • Journal Title

      Nature Commun

      Volume: 2 Pages: 181-181

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] NRF2 mutation confers malignant potential and resistance to chemoradiation therapy in advanced esophageal squamous cancer2011
    • Author(s)
      Shibata T, Kokubu A, Saito S, Narisawa-Saito M, Sasaki H, Aoyagi K, Yoshimatsu Y, Tachimori Y, Kushima R, Kiyono T, Yamamoto M
    • Journal Title

      Neoplasia

      Volume: 13 Pages: 864-873

    • DOI

      10.1593/neo.11750

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Oral azathioprine leads to higher incorporation of 6-thioguanine in DNA of skin than liver : The protective role of the Keap1/Nrf2/ARE pathway2011
    • Author(s)
      Kalra S, Zhang Y, Knatko EV, Finlayson S, Yamamoto M, Dinkova-Kostova AT
    • Journal Title

      Cancer Prev Res

      Volume: 4 Pages: 1665-1674

    • DOI

      10.1158/1940-6207.capr-11-0137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Specific contribution of the erythropoietin gene 3' enhancer to hepatic erythropoiesis after late embryonic stages2011
    • Author(s)
      Suzuki N, Obara N, Pan X, Watanabe M, Jishage K, Minegishi N, and Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 31 Pages: 3896-3905

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23659167

  • [Journal Article] The transcriptome of Nrf2^<-/-> Mice provides evidence for impaired cell cycle progression in the development of cigarette-smoke-induced emphysematous changes2010
    • Author(s)
      Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schuller J, Xu H, Taguchi K, Yamamoto M, Muller T
    • Journal Title

      Tox Sci

      Volume: 115 Pages: 238-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Deletion of Nuclear Factor-E2-Related Factor-2 Leads to Rapid Onset and Progression of Nutritional Steatohepatitis in Mice2010
    • Author(s)
      Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M.
    • Journal Title

      Am J Physiol Gastrointest Liver Physiol 298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Genetic analysis of cytoprotective functions supported by graded expression of Keap12010
    • Author(s)
      Taguchi K, Maher JM, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M
    • Journal Title

      Mol Cell Biol

    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation2010
    • Author(s)
      Motohashi H, Kimura M, Fujita R, Takayama M, Pan XQ, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M.
    • Journal Title

      Blood 115

      Pages: 677-686

    • NAID

      40019431698

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance2010
    • Author(s)
      Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, Itoh K, Yamamoto M, Hizawa N., Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance
    • Journal Title

      Respir Res

      Volume: 11 Pages: 31-42

    • NAID

      120007138178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p622010
    • Author(s)
      Komatsu M, Kurokawa H, Waqun S, Iaguchi K, Kobayashi A, Ichimura Y, Sou Y-S, Ueno I, Sakamoto A, Tong KI, Kim M, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M
    • Journal Title

      Nature Cell Biol 12

      Pages: 213-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] ストレスと生体反応. Nrf2-Keap1システムによるストレス応答制御2010
    • Author(s)
      宇留野晃、森口尚、山本雅之
    • Journal Title

      Diabetes Frontier

      Volume: 21 Pages: 412-417

    • Data Source
      KAKENHI-PROJECT-22890014

  • [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation2010
    • Author(s)
      Motohashi H, Kimura M, Fujita R, Takayama M, Pan XQ, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M
    • Journal Title

      Blood 115

      Pages: 677-686

    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene.2010
    • Author(s)
      Becks L, Prince M, Burson H, Christophe C, Broadway M, Itoh K, Yamamoto M, Mathis M, Orchard E, Shi R, McLarty J, Pruitt K, Zhang S, Kleiner-Hancock HE.
    • Journal Title

      BMC Cancer

      Volume: 10 Pages: 540-556

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Keap 1 homodimer is a forked-stem structure with two large spheres en closing the intervening, double glycine repeat, and C-terminal domains2010
    • Author(s)
      Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M.
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 2842-2847

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene2010
    • Author(s)
      Becks L, Prince M, Burson H, Christophe C, Broadway M, Itoh K, Yamamoto M, Mathis M, Orchard E, Shi R, McLarty J, Pruitt K, Zhang S, Kleiner-Hancock HE
    • Journal Title

      BMC Cancer

      Volume: 10 Pages: 540-556

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance.2010
    • Author(s)
      Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, Itch K, Yamamoto M, Hizawa N.
    • Journal Title

      Respir Res

      Volume: 11 Pages: 31-42

    • NAID

      120007138178

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] The rise of antioxidant signaling-the evolution and hormetic actions of Nrf22010
    • Author(s)
      Maher J, Yamamoto M
    • Journal Title

      Antioxidant Redox Biol

      Volume: 244 Pages: 4-15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Cytochrome P450 2A5 constitutive expression and induction by heavy metalsH, is dependent on redox-sensitive transcription factor Nrf2 in liver.2010
    • Author(s)
      lammsa v, levonen AL, Leinonen H Yla-Herttuala S, Yamamoto M, Hakkola J.
    • Journal Title

      Chem Res Toxicol

      Volume: 23 Pages: 977-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response.2010
    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G.
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 30 Pages: 1553-1556

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p622010
    • Author(s)
      M. Komatsu, H. Kurokawa, S. Waguri, K. Taguchi, A. Kobayashi, Y. Ichimura, Y-S. Sou, I. Ueno, A. Sakamoto, K.I. Tong, M. Kim, S. Iemura, T. Natsume, T. Ueno, E. Kominami, H. Motohashi, K. Tanaka, M. Yamamoto
    • Journal Title

      Nat. Cell Biol. 12

      Pages: 213-223

    • Data Source
      KAKENHI-PROJECT-16059101

  • [Journal Article] Role of NrfZ and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells2010
    • Author(s)
      Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, Maruyama A, Yamamoto M, Shirasawa T.
    • Journal Title

      J.Biochem. 147

      Pages: 73-81

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Genetic analysis of hierarchical regulation for Gatal and NF-E2 p45 gene expression in megakaryopoiesis2010
    • Author(s)
      Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 30 Pages: 2668-2680

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap12010
    • Author(s)
      Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y. S., Ueno, I., Sakamoto, A., Tong, K. I., Kim, M., Nishito, Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M.
    • Journal Title

      Nature Cell Biol 12

      Pages: 213-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response2010
    • Author(s)
      Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T
    • Journal Title

      J Biol Chem

      Volume: 285 Pages: 23970-23984

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy.2010
    • Author(s)
      Uno K, Prow TW, Bhutto IA, Yerrapureddy A, McLeod DS, Yamamoto M, Reddy SP, Lutty GA.
    • Journal Title

      Exp Eye Res.

      Volume: 90 Pages: 493-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response2010
    • Author(s)
      Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 30 Pages: 1553-1556

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Increased susceptibility of Nrf2 null mice to 1-bromopropane-induced hepatotoxicity2010
    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G
    • Journal Title

      Toxicol Sci

      Volume: 115 Pages: 596-606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Genetic analysis of cytoprotective functions supported by graded expression of Keapl.2010
    • Author(s)
      Taguchi K, Maher J, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M.
    • Journal Title

      Mol Cell Biol

      Volume: 30 Pages: 3016-3026

    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Select heterozygous Keapl mutations have a dominant-negative effect on wild-type Keapl in vivo.2010
    • Author(s)
      Suzuki T, Maher J, Yamamoto M.
    • Journal Title

      Cancer Res.

      Volume: 71 Pages: 1700-1709

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Increased susceptibility of Nrf2 null mice to 1-bromopropane-induced hepatotoxicity.2010
    • Author(s)
      Liu F, Ichihara S, Valentine WM, Itch K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G.
    • Journal Title

      Toxicol Sci

      Volume: 115 Pages: 596-606

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] ストレスと生体反応～Nrf2-Keaplシステムによるストレス応答制御～2010
    • Author(s)
      宇留丑晃、森口尚、山本雅之
    • Journal Title

      Diabetes Frontier

      Volume: 21 Pages: 412-417

    • Data Source
      KAKENHI-PROJECT-22890014

  • [Journal Article] Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice2010
    • Author(s)
      Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I
    • Journal Title

      Clin Immunol

      Volume: 137 Pages: 234-241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] The transcriptome of Nrf2^-/- Mice provides evidence for impaired cell cycle progression in the development of cigarette-smoke-induced emphysematous changes.2010
    • Author(s)
      Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schuller J, Xu H, Taguchi K, Yamamoto M, Muller T.
    • Journal Title

      Tox Sci

      Volume: 115 Pages: 238-252

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Novel type of E3 ligase for Ufm 1-conjugating system2010
    • Author(s)
      Tatsumi K, Sou Y-S, Tada N, Nakamura E, Iemura S-i, Natsume T, Kang SH, Chung C H, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.
    • Journal Title

      J Biol Chem 285

      Pages: 5417-5427

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Suppression of SLCIIA2 Expression is essential to maintain duodenal integrity during dietary iron overload.2010
    • Author(s)
      Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S.
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 677-685

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Genetic analysis of cytoprotective functions supported by graded expression of Keap12010
    • Author(s)
      Taguchi K, Maher J, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M
    • Journal Title

      Mol Cell Biol

      Volume: 30 Pages: 3016-3026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap12010
    • Author(s)
      Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.S., Ueno, I., Sakamoto, A., Tong, K.I., Kim, M., Nishito, Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M
    • Journal Title

      Nat Cell Biol. 12

      Pages: 213-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung.2010
    • Author(s)
      Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M.
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 1833-1843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] WFA-positive sialylated MUC1 is a high-sensitivity biliary marker for intrahepatic cholangiocarcinoma2010
    • Author(s)
      Matsuda, A., Kuno, A., Kawamoto, K., Matsuzaki, H., Irimura, T., Ikehara, Y., Zen, Y., Nakanuma, Y., Yamamoto, M., Ohkohchi, N., Shoda, J., Hirabayashi, J., Narimatsu, H
    • Journal Title

      Hepatology

      Volume: 52 Pages: 174-182

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300275

  • [Journal Article] The anemia of the newborn induces erythropoietin expression in the developing mouse retina2010
    • Author(s)
      Scheerer N, Dunker N, Imagawa S, Yamamoto M, Suzuki N, Fandrey J., The anemia of the newborn induces erythropoietin expression in the developing mouse retina
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice2010
    • Author(s)
      Sugimoto, H., Okada, K., Shoda, J., Warabi, E., Ishige, K., Ueda, T., Taguchi, K., Yanagawa, T., Nakahara, A., Hyodo, I., Ishii, T., Yamamoto, M
    • Journal Title

      Am J Physiol

      Volume: 298 Pages: 283-294

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300275

  • [Journal Article] Nrf2 is closely related to allergic airway inflammatory responses induced bylow-dose diesel exhaust particles in mice.2010
    • Author(s)
      Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I.
    • Journal Title

      Clin Immunol

      Volume: 137 Pages: 234-241

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Suppression of AhR signaling pathway is associated with the down-regulation of UDP-glucurono syltransferases during BBN-induced urinary bladder carcinogenesis in mice2010
    • Author(s)
      Iida K, Itoh K, Mimura J, Ohyama C, Fujii-Kuriyama Y, Shimazui T, Akaza H, Yamamoto M
    • Journal Title

      J Biochem 147

      Pages: 353-360

    • NAID

      10027874393

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] Novel regulation of the Nrf2-Keap1 pathway by the selective autophagy substrate p622010
    • Author(s)
      Komatsu M, Kurokawa H, Waguri S, Taguchi K, Kobayashi A, Ichimura Y, Sou Y-S, Ueno I, Sakamoto A, Tong KI, Kim M, Iemura S, Natsume T, Ueno T, Kominami E, Motohashi H, Tanaka K, Yamamoto M
    • Journal Title

      Nature Cell Biol 12

      Pages: 213-223

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy2010
    • Author(s)
      Uno K, Prow TW, Bhutto IA, Yerrapureddy A, McLeod DS, Yamamoto M, Reddy SP, Lutty GA
    • Journal Title

      Exp Eye Res

      Volume: 90 Pages: 493-500

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Genetic analysis of hierarchical regulation for Gata1 and NF-E2 p45 gene expression in megakaryopoiesis2010
    • Author(s)
      Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M
    • Journal Title

      Mol Cell Biol 12

      Pages: 3016-3026

    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] Suppression of SLC11A2 Expression is essential to maintain duodenal integrity during dietary iron overload2010
    • Author(s)
      Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S
    • Journal Title

      Am J Pathol

      Volume: 177 Pages: 677-685

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver2010
    • Author(s)
      Lamsa V, Levonen AL, Leinonen H, Yla-Herttuala S, Yamamoto M, Hakkola J
    • Journal Title

      Chem Res Toxicol

      Volume: 23 Pages: 977-985

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway.2010
    • Author(s)
      Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S.
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 9095-9105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung2010
    • Author(s)
      Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M
    • Journal Title

      Carcinogenesis

      Volume: 31 Pages: 1833-1843

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway2010
    • Author(s)
      Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S
    • Journal Title

      Cancer Res

      Volume: 70 Pages: 9095-9105

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] The flavanol(-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway.2010
    • Author(s)
      Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Dore S.
    • Journal Title

      J Cereb Blood Flow Metab

      Volume: 30 Pages: 1951-1961

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defense and lipid metabolism as primary Nrf2-dependent pathways in the liver.2010
    • Author(s)
      Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK.
    • Journal Title

      J Proteomics

      Volume: 73 Pages: 1612-1631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defense and lipid metabolism as primary Nrf2-dependent pathways in the liver2010
    • Author(s)
      Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK
    • Journal Title

      J Proteomics

      Volume: 73 Pages: 1612-1631

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] The anemia of the newborn induces erythropoietin expression in the developing mouse retina.2010
    • Author(s)
      Scheerer N, Dunker N, Imagawa S, Yamamoto M, Suzuki N, Fandrey J.The anemia of the newborn induces erythropoietin expression in the developing mouse retina.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol

      Volume: 299

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22659056

  • [Journal Article] Loss of the Gata1 gene IE exon leads to variant transcript expression and the production of a GATA1 protein lacking the N-terminal domain2010
    • Author(s)
      Kobayashi E, Shimizu R, Kikuchi Y, Takahashi S, Yamamoto M
    • Journal Title

      J Biol Chem 285

      Pages: 773-783

    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] Keap1 homodimer is a forked-stem structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains2010
    • Author(s)
      Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M.
    • Journal Title

      Proc Natl Acad Sci USA 285

      Pages: 5417-5427

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells2010
    • Author(s)
      Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E.
    • Journal Title

      FASEB J 24

      Pages: 39-48

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19GS0312

  • [Journal Article] Keap1 homodimer is a forked-stem structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains2010
    • Author(s)
      Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 2842-2847

    • Data Source
      KAKENHI-PROJECT-17013017

  • [Journal Article] Regulation of Notch1 signaling by Nrf2 : Implications for tissue regeneration2010
    • Author(s)
      Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak M-K, Misra V, Biswal S, Yamamoto M, Kensler TW
    • Journal Title

      Science Signaling

      Volume: 3 Pages: 1-11

    • Peer Reviewed