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Kakizuka Akira  垣塚 彰

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KAKIZUKA Akira  垣塚 彰

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Researcher Number 80204329
Other IDs
External Links
Affiliation (Current) 2022: 京都大学, 生命科学研究科, 教授
Affiliation (based on the past Project Information) *help 2011 – 2021: 京都大学, 生命科学研究科, 教授
2014 – 2015: 京都大学, 大学院生命科学研究科, 教授
2009: Kyoto University, 大学院・生命科学研究科, 教授
2005 – 2009: 京都大学, 生命科学研究科, 教授
2002 – 2005: 京都大学, 大学院・生命科学研究科, 教授 … More
2002: Kyoto University, Graduate school of Biostudies, Professor, 大学院生命科学研究科, 教授
2001 – 2002: 京都大学, 生命科学研究科, 教授
2001: Osaka Bioscience Institute, The fourth department, Head, 第4研究部, 部長
2000: Osaka Bioscience Institute, 4<@D1TH@>D1 DEPARTMENT, HEAD, 第4研究部, 研究部長
1998 – 2000: 大阪バイオサイエンス研究所, 第4研究部, 部長(研究職)
1999: 財団法人 大阪バイオサイエンス研究所, 第4研究部, 研究部長
1999: Osaka Bioscience Institute, The fourth department, Head, 第4研究部, 部長
1998 – 1999: 大阪バイオサイエンス研究所, 第4研究部, 部長
1998: 大阪バイオサイエンス研究所, 部長(研究職)
1997 – 1998: (財)大阪バイオサイエンス研究所, 第4研究部, 部長
1997: 大坂バイオサイエンス研究所, 第4研究所, 部長(研究職)
1997: 大阪バイオサイエンス研究所, 第4研究室, 部長
1996: 京都大学, 大学院・医学研究科, 教授
1995 – 1996: Kyoto University, Faculty of Medicine, Department of Pharmacology, Associate Pro, 医学研究科, 助教授
1995: 京都大学, 医学部, 助教授
1993 – 1995: 京都大学, 医学部, 講師 Less
Review Section/Research Field
Principal Investigator
Pathological medical chemistry / Pathological medical chemistry / Biological Sciences / Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Except Principal Investigator
Biological Sciences / Ophthalmology / Pathological medical chemistry / Urology / Dermatology
Keywords
Principal Investigator
VCP / ポリグルタミン / AAA ATPase / アポトーシス / 神経細胞死 / 細胞死 / APL / アミノ酸修飾 / PML / RAR … More / ドミナント・ネガティブ / プログラム細胞死 / MJD / p97 / SEK1 / ATPase / ストレス / 蛋白質 / 飢餓 / neuronal cell death / polyglutamine / 神経変性疾患 / 白血病 / 染色体転座 / 抗核抗体 / レチノイン酸 / fas / 遺伝子治療 / エストロゲン / 前立腺癌 / CAGリピート / SEKI-JNK / PML body / ドロソフィラ / 出芽酵母 / 腺癌 / 扁平上皮癌 / 温度感受性株 / 細胞周期 / ATP / p160ROCK / p140mDia / rho p21 / PC12 / 蛋白質凝集体 / amino acid modification / protein aggregates / VCP/p97 / 新規機能 / 寛解 / fas抗原 / 脂溶性ホルモン / 受容体 / 遺伝子療法 / トランスジェニック・マウス / エストロジェン / 疾患モデル / 皮フ成型 / CAG / 優性遺伝 / デスシグナル / 癌 / 遺伝子発現 / デスドメイン / Fas / 融合蛋白質 / 急性前骨髄球性白血病 / マシャド・ジョセフ病 / ポリグタミン / 小脳失調 / プルキンエ細胞 / ベータシート / 癌治療 / がん治療 / タモキシフェン / SEKI / 酸化修飾 / ATPase活性 / Hsp70 / RNAi / 亜砒酸 / 前立腺ガン / ASK1 / 酸化ストレス / スプライニングバリアント / AAA / リン酸化 / アセチル化 / Cdc48 / 脱ユビキチン化 / フィードバック機構 / ペウルオキシゾーム / カタラーゼ / ROS / 癌の悪性化 / 細胞内局在 / 紡錘体極 / タイムラプス解析 / p47 / DNA合成 / 細胞増殖 / 活性阻害剤 / ERストレス / 網膜色素変性症 / 緑内障 / 酵素 / 胞・組織 / 阻害剤 / 繊維状構造物 / グルコース代謝 / リン脂質 / rhop21 / 細胞接着斑 / インテグリン / アクチン重合 / 神経可塑性 / 細胞接着 / ボツリヌスC_3酵素 / PKN / P160^<ROCK> / 細胞形態変化 / SH_3 / focal adhesion / intergrin / actin polymerization / Neural plasticity / cell adhesion / Machado-Joseph病 / ストレス応答 / Machado-Josephe病 / ERDA1 / HD / Machada-Joseph disease / CAG Repeat / stress response / 空胞 / 蛋白質凝集 / Cell death / vacuole / protein aggregate / 空胞形成 / Lewy小体 / ポリグルタミ / プロセシング / 空胞変性 / 小胞体 / 小胞体ストレス / vacuole formation / Lewy body / 酸化 / ミスセンス変異 / IBMPFD / 凝集体形成 / oxidation / polyglutmamine / ユビキチン化 / 細胞内不要蛋白質 / 新規創薬標的 / 新規化合物 / 細胞・組織 / オートファジー / 標的蛋白質 / ATP制御 / 恒常性維持 / パーキンソン病 / 心筋梗塞 / 脳梗塞 / 栄養飢餓 / 恒常性維持機構 / 創薬基盤 / 飢餓応答 / 疾患治療 / 細菌 / フェロトーシス / 細胞保護 / p97/VCP / アトピー性皮膚炎 / 新規治療 … More
Except Principal Investigator
ポリグルタミン / VCP / p97 / レチノイン酸 / 神経変性疾患 / 分子シャペロン / 神経変性変異 / 造血器腫瘍 / 転座関連遺伝子 / 遺伝子機能 / 染色体異常 / FISH / PCR / 急性前骨髄球性白血病 / レチノイン酸レセプター / アポトーシス / AAA ATPase / polyglutamine / 凝集体 / 酵母 / アミロイド / 神経保護 / 眼難治疾患 / 遺伝子治療 / 前立腺癌 / PSA / GFP / TSTA system / Hsp104 / buthionine sulfoximine / 基本転写因子 / 特異的転写調節因子 / 転写因子復合体 / 転写因子ファミリー / 細胞機能制御 / 細胞増殖・分化 / 遺伝子欠損マウス / 転写因子ネットワーク / 機能ドメイン / 細胞機能 / 転写活性化機構 / 遺伝子特異的転写因子 / ノックアウト・マウス / 転写調節因子 / DNA非結合型因子 / 胚発生 / HBP-1a / IRF-1,-2 / 細胞分化 / 分子誘導療法 / レチノイド / PML / ポリプレン酸 / ブファリン / AML1遺伝子 / BCL2遺伝子 / MLL遺伝子 / GCL6遺伝子 / 分化誘導療法 / Am-80 / 細胞内レチノイン酸結合蛋白 / ユビキチン・プロテアゾーム / トランスジェニック・マウス / レチノイドアンタゴニスト / 神経細胞死 / ポリグルタミン病 / NAIP / トリブレットリピートインスタビリティー / ハンチントン病 / MJD / DRPLA / ポリグルタミン酸 / トリプレットリピートインスタビリティー / ダイナミックミューテーション / トリプレットリピート病 / 小脳変性疾患 / 脊髄性筋萎縮症 / マシャドジュセフ病 / 分子医学 / 歯状核赤核淡蒼球ルイ体萎縮症 / フォルディング / 腺ガン / 出芽酵母 / CFTR / ER stress / ubiquitin / Lewy body / parkinson's disease / Alzheimer's disease / AAA+ Superfamily蛋白質 / 酵母プリオン / AAA superfamily蛋白質 / Cdc48 / cross-seeding / ミスセンス変異 / IBMPFD / 凝集体形成 / 眼細胞生物学 / プロスタグランジン受容体 / トロンボキサン受容体 / 受容体リガンド結合 / 細胞内情報伝達 / 受容体アイソフォーム / 受容体遺伝子 / 体内分布 / トロンボキサン受容体異常症 / プロスタノイド受容体分子進化 / プロスタサイクリン受容体体内分布 / トロンボキサン受容体アイソフォーム / ラット脳EP_3受容体 / プロスタグランジン受容体遺伝子 / プロスタグランジン / トロンボキサン / 受容体 / G蛋白質 / 情報伝達 / 血小板異常症 / 脳内分布 / 遺伝子 / アポプトーシス / 胸腺 / prostaglandin / thromboxane receptor / ligand binding / signal transduction / receptor isoform / gene receptor / receptor distribution / receptor abnormality / 国際学術 / 海外派遣 / 癌 / 細胞社会学 / シグナル伝達 / 細胞周期 / 薬品設計 / ウイルス発癌 / 細胞接着 / 癌治療 / 化学発癌 / 情報交換 / ドラッグデザイン / 癌遺伝子治療 / 癌化学療法 / 細胞増殖 / International Scientific Research / Cancer / Information Exchange / Signal Transduction / Cell Cycle / Cell Adhesion / Drug Design / Gene Therapy / レチノイン酸受容体 / トランスジェニックマウス / ドミナント・ネガティブ / 角化症 / ケラチン / 表皮分化 / K14プロモーター / ドミナント-ネガティブ / 炎症性角化症 / トランスジェニック マウス / 皮膚特異的発現 / ドミナント ナガティブ / レイノイン酸レセプター / Retinoic acid Receptor / Transgenic mouse / Dominant-negative / keratosis / Retinoic acid / keratin / keratinocyte differentiation / K14 promotor / 転写調節 / 制御因子 / 標的遺伝子 / 変異マウス / 転写仲介因子 / 発生 / 造血系 / 神経系 / ノックアウトマウス / 分化 / transcriptional control / transcriptional regulator / target genes / mutant mice / transcriptional mediators / development / hematopoietic system / neuronal system / LNCAP細胞 / アンドロゲン反応性 / TSTAsystem / アデノウィルスベクター / LNCaP細胞 / GEP / アデノウイルス / Prostate cancer / gene therapy / LNCaP cell / androgen responsiveness / adenovirus vector / 筋萎縮性側索硬化症 / 運動ニューロン / 転写因子 / 誘導 / P19細胞 / 脊髄 / MOTOR NEURON / AMYOTOROPHICLATERAL SCLEROSIS / TRANSCRIPTION FACTORS / INDUCTION / P19 CELLS / SPINALOORD / AAAスーパーファミリー蛋白質 / AAA+ スーパーファミリー蛋白質 / コンフォーメーション / 構造変換 / コンフォーメーション病 / neurodegerative disease / molecular chaperone / amyloid / AAA superfamily protein / aggregates / 3酸化砒素 / 腎癌 / Buthionine sulfooximine / 活性化酸素 / 三酸化ヒ素 / arsenic trioxide / apoptosis / prostate cancer / renal cancer / reactive oxveren species / 眼疾患 / 創薬 / スクリーニング Less
  • Research Projects

    (43 results)
  • Research Products

    (180 results)
  • Co-Researchers

    (147 People)
  •  Construction of a new drug discovery platform for atopic dermatitisPrincipal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      2021 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Kyoto University
  •  Elucidation of novel functions of VCP, a major ATPase in the cellPrincipal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Kyoto University
  •  Analyses on novel functions of VCP, a major ATPase in the cellPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  プロテアゾーム阻害下におけるユビキチン化蛋白質の除去機構の解明Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Development of neuroprotective drugs

    • Principal Investigator
      Ikeda Hanako
    • Project Period (FY)
      2015
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Ophthalmology
    • Research Institution
      Kyoto University
  •  Development of neuroprotective treatment for incurable ocular diseases

    • Principal Investigator
      YOSHIMURA Nagahisa
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Ophthalmology
    • Research Institution
      Kyoto University
  •  Analyses of the function and regulation of VCP, a major ATPase in the cellsPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  Mechanisms for the regulation of growth and cell death in cancer cellsPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  異常蛋白質が引き起こす空胞形成の分子解析

    • Principal Investigator
      堀 清次
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  VCPのATPase活性を阻害する物質の検索Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  ポリグルタミンの凝集体形成、細胞障害におけるストレス蛋白質の役割

    • Principal Investigator
      木村 洋子
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  Functional analyses of VCP protein in neuronal cell deathPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  ポリグルタミンの凝集体形成、細胞障害におけるストレス蛋白質の役割

    • Principal Investigator
      KIMURA Yoko
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  異常蛋白質が引き起こす空胞形成の分子解析

    • Principal Investigator
      堀 清次
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Molecular analyses of cell death and vacuole formation that are induced by abnormal protein accumulationPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      KYOTO UNIVERSITY
  •  Development of As203-besed new chemotherapy for advanced prostate cancer

    • Principal Investigator
      KAKEHI Yoshiyuki
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      KAGAWA UNIVERSITY(FACULTY OF MEDICINE)
  •  The Role of stress proteins in the aggregation and cytotoxicity of polyglutamine

    • Principal Investigator
      KIMURA Yoko
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Metropolitan Organization for Medical Research
  •  単一遺伝子異常による神経細胞死

    • Principal Investigator
      池田 穣衛 (池田 穰衛)
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Tokai University
  •  がん細胞におけるアポトーシスの分子解析Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
      Osaka Bioscience Institute
  •  Molecular analysis on nqurodegenerationPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      OSAKA BIOSCIENCE INSTITUTE(OBI)
  •  THE ANALYSIS OF PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS BASED ON THE ESTABLISHMENT OF IN VITRO MOTOR NEURONAL CELL LINES

    • Principal Investigator
      TANABE Yasuto
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  アポトーシスの分子解析とその癌治療への応用Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Osaka Bioscience Institute
  •  A novel gene transfer method for prostate-specific and potent expression and its utilization in gene therapy

    • Principal Investigator
      KAKEHI Yoshiyuki
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Urology
    • Research Institution
      KYOTO UNIVERSITY
  •  ホルモン依存性プログラム細胞死の癌治療への応用Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka Bioscience Institute
      Kyoto University
  •  Target genes and biological role of transcription factors in animal

    • Principal Investigator
      ISHII Shunsuke
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      RIKEN INSTITUTE
  •  Identification and analysis of the genes responsible for inherited neurodegenerative disordersPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  遺伝性神経変性症の原因遺伝子の同定と解析Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  急性前骨髄球性白血病の発症及び寛解機構の解析Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  遺伝性神経変性疾患の分子機構の解析Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  ホルモン依存性プログラム細胞死の分子機構解析とその応用Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  rho p21 in Neural Development and PlasticityPrincipal Investigator

    • Principal Investigator
      KAKIZUKA Akira, 成宮 周
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KYOTO UNIVERSITY
  •  An animal model for keratosis

    • Principal Investigator
      TANAKA Toshihiro, 今村 貞夫
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Dermatology
    • Research Institution
      KYOTO UNIVERSITY
  •  急性前骨髄球性白血病の発症及び寛解機構の解析Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究

    • Principal Investigator
      大野 竜三
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  造血器腫瘍における転座関連遺伝子の機能とその臨床応用

    • Principal Investigator
      鎌田 七男
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hiroshima University
  •  ホルモン依存性プログラム細胞死の開発と応用Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  Information Exchange on Cancer Research with North American

    • Principal Investigator
      YAMAMOTO Tadashi
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      The University of Tokyo
  •  造血器腫瘍における転座関連遺伝子の機能とその臨床応用

    • Principal Investigator
      鎌田 七男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Hiroshima University
  •  細胞の機能分化に関わる遺伝子制御ネッドワーク-遺伝子の階層的制御システム-

    • Principal Investigator
      岩渕 雅樹
    • Project Period (FY)
      1993 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  急性前骨髄球性白血病の発症及び寛解機構の解析Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  ホルモン依存性プログラム細胞死の開発と応用Principal Investigator

    • Principal Investigator
      垣塚 彰
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  Structures and functions of the Prostanoid Receptors

    • Principal Investigator
      NARUMIYA Shuh
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      KYOTO UNIVERSITY

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] Innovative Medicine: Basic research and develpoment2015

    • Author(s)
      Kakizuka, A.
    • Publisher
      Springer
    • Data Source
      KAKENHI-PUBLICLY-15H01181
  • [Book] Annual Review神経 タンパク質の品質管理と神経変性2014

    • Author(s)
      木村洋子、垣塚 彰 編集:鈴木則宏、祖父江元、荒木信夫、宇川義一、川原信隆
    • Total Pages
      290
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Book] ヒトの分子生物学(分子生物学第2版(編集:柳田光弘、西田栄介、野田亮))2009

    • Author(s)
      垣塚彰
    • Publisher
      東京科学同人
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Book] 脳神経科学 イラストレイテッド 改訂第2版(第7章-6 ポリグルタミン病)2006

    • Author(s)
      垣塚 彰他(編集:森 寿, 真鍋俊也, 渡辺雅彦, 岡野栄之, 宮川 剛)
    • Total Pages
      372
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Book] ポリグルタミン病(脳神経科学イラストレイテッド改訂第2版(編集:森寿、真鍋俊也、渡辺雅彦、岡野栄之、宮川剛))2006

    • Author(s)
      垣塚彰
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Book] 脳神経科学 イラストレイテッド 改訂第2版(第7章-6 ポリグルタミン病)2006

    • Author(s)
      垣塚 彰他(編集:森 寿, 真鍋俊也, 渡辺雅彦, 岡野栄之, 宮川 剛)
    • Total Pages
      372
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17028028
  • [Book] 脳神経科学 イラストレイテッド 改訂第2版(第7章-6ポリグルタミン病)2006

    • Author(s)
      垣塚彰, 他(編集 森 寿, 真鍋俊也, 渡辺雅彦, 岡野栄之, 宮川 剛)
    • Total Pages
      372
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Book] 脳神経科学 イラストレイテッド 改訂第2版(第7章-6 ポリグルタミン病)2006

    • Author(s)
      垣塚 彰他(編集:森 寿, 真鍋俊也, 渡辺雅彦, 岡野栄之, 宮川 剛)
    • Total Pages
      372
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Book] ゲノムと疾患(第7章 ゲノムの不安定性と神経系疾患)2004

    • Author(s)
      垣塚 彰, 他(編集 村松正實)
    • Total Pages
      214
    • Publisher
      南山堂
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Effect of VCP modulators on gene expression profiles of retinal ganglion cells in an acute injury mouse model2020

    • Author(s)
      Hasegawa Tomoko、Ikeda Hanako Ohashi、Gotoh Norimoto、Iida Kei、Iwai Sachiko、Nakano Noriko、Kakizuka Akira、Tsujikawa Akitaka
    • Journal Title

      Sci Rep.

      Volume: 10 Pages: 4251-4251

    • DOI

      10.1038/s41598-020-61160-6

    • NAID

      120006870291

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19610, KAKENHI-PROJECT-18K16923, KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-19H03435
  • [Journal Article] Safety and effectiveness of a novel neuroprotectant, KUS121, in patients with non-arteritic central retinal artery occlusion: An open-label, non-randomized, first-in-humans, phase 1/2 trial2020

    • Author(s)
      Ikeda HO, Muraoka Y, Hata M, Sumi E, Ikeda T, Nakagawa T, Abe H, Tada H, Morita S, Kakizuka A, Yoshimura N, Tsujikawa A
    • Journal Title

      PLoS One

      Volume: 15

    • DOI

      10.1371/journal.pone.0229068

    • NAID

      120006799242

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19610, KAKENHI-PROJECT-19K09991, KAKENHI-PROJECT-19H03435
  • [Journal Article] Genetic screening for potassium channel mutations in Japanese autosomal dominant spinocerebellar ataxia.2020

    • Author(s)
      Tada Yui、Kume Kodai、Matsuda Yukiko、Kurashige Takashi、Kanaya Yuhei、Ohsawa Ryosuke、Morino Hiroyuki、Tabu Hayato、Kaneko Satoshi、Suenaga Toshihiko、Kakizuka Akira、Kawakami Hideshi
    • Journal Title

      J Hum Genet.

      Volume: 65(4) Pages: 363-369

    • DOI

      10.1038/s10038-019-0717-y

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07994, KAKENHI-PROJECT-19H03435
  • [Journal Article] Ellagic acid, extracted from Sanguisorba officinalis, induces G1 arrest by modulating PTEN activity in B16F10 melanoma cells.2019

    • Author(s)
      Tan YH, Shudo T, Yoshida T, Sugiyama Y, Si JY, Tsukano C, Takemoto Y, Kakizuka A.
    • Journal Title

      Genes Cells.

      Volume: 24 Pages: 688-704

    • DOI

      10.1111/gtc.12719

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03435
  • [Journal Article] PPARα-Mediated Positive-Feedback Loop Contributes to Cold Exposure Memory.2019

    • Author(s)
      Alfaqaan Soaad、Yoshida Tomoki、Imamura Hiromi、Tsukano Chihiro、Takemoto Yoshiji、Kakizuka Akira
    • Journal Title

      Scientific Reports

      Volume: 9 Pages: 4538-4538

    • DOI

      10.1038/s41598-019-40633-3

    • NAID

      120006591437

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-19K16124, KAKENHI-PROJECT-16H05151
  • [Journal Article] Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E2 synthesis in the brain and their behavioral relevance.2019

    • Author(s)
      Nie X, Kitaoka S, Shinohara M, Kakizuka A, Narumiya S, Furuyashiki T.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 17548-17548

    • DOI

      10.1038/s41598-019-54082-5

    • NAID

      120006996939

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PLANNED-18H05429, KAKENHI-PUBLICLY-19H05021, KAKENHI-PROJECT-17K08593, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-19H03435
  • [Journal Article] Emodin, as a mitochondrial uncoupler, induces strong decreases in adenosine triphosphate (ATP) levels and proliferation of B16F10 cells, owing to their poor glycolytic reserve.2019

    • Author(s)
      Sugiyama, U., Shudo, T., Hosokawa, S., Watanabe, A., Nakano, M., Kakizuka, A.
    • Journal Title

      Genes Cells.

      Volume: 8 Pages: 569-584

    • DOI

      10.1111/gtc.12712

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K16912, KAKENHI-PROJECT-19H03435
  • [Journal Article] OLIVe: A Genetically Encoded Fluorescent Biosensor for Quantitative Imaging of Branched-Chain Amino Acid Levels inside Single Living Cells.2019

    • Author(s)
      Yoshida Tomoki、Nakajima Hitomi、Takahashi Sena、Kakizuka Akira、Imamura Hiromi
    • Journal Title

      ACS Sens.

      Volume: 4 Pages: 3333-3342

    • DOI

      10.1021/acssensors.9b02067

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-19H03435, KAKENHI-PROJECT-19K22386
  • [Journal Article] KUS121, a valosin-containing protein modulator, attenuates ischemic stroke via preventing ATP depletion.2019

    • Author(s)
      Kinoshita H, Maki T, Yasuda K, Kishida N, Sasaoka N, Takagi Y, Kakizuka A, Takahashi R.
    • Journal Title

      Sci Rep.

      Volume: 9 Pages: 11519-11519

    • DOI

      10.1038/s41598-019-47993-w

    • NAID

      120006786947

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03435
  • [Journal Article] Cardioprotective Effects of VCP Modulator KUS121 in Murine and Porcine Models of Myocardial Infarction.2019

    • Author(s)
      Ide Yuya, at al.
    • Journal Title

      JACC Basic Transl Sci.

      Volume: 4 Pages: 701-714

    • DOI

      10.1016/j.jacbts.2019.06.001

    • NAID

      120006734885

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K15888, KAKENHI-PROJECT-19H03435
  • [Journal Article] Branched chain amino acids attenuate major pathologies in mouse models of retinal degeneration and glaucoma2018

    • Author(s)
      Hasegawa Tomoko、Ikeda Hanako Ohashi、Iwai Sachiko、Muraoka Yuki、Tsuruyama Tatsuaki、Okamoto-Furuta Keiko、Kohda Haruyasu、Kakizuka Akira、Yoshimura Nagahisa
    • Journal Title

      Heliyon

      Volume: 4

    • DOI

      10.1016/j.heliyon.2018.e00544

    • NAID

      120006425863

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16K20316, KAKENHI-PROJECT-16H05151
  • [Journal Article] Analysis of mitochondrial function in human induced pluripotent stem cells from patients with mitochondrial diabetes due to the A3243G mutation.2018

    • Author(s)
      Matsubara M, Kanda H, Imamura H, Inoue M, Noguchi M, Hosoda K, Kakizuka A, Nakao K.
    • Journal Title

      Sci Rep.

      Volume: 8 Pages: 949-949

    • DOI

      10.1038/s41598-018-19264-7

    • NAID

      120006502575

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-17H01566, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-17H03654
  • [Journal Article] KUS121, an ATP regulator, mitigates chorioretinal pathologies in animalmodels of age-related macular degeneration.2018

    • Author(s)
      Muraoka, Y., Yoshimura, N., et al.
    • Journal Title

      Heliyon.

      Volume: 4

    • DOI

      10.1016/j.heliyon.2018.e00624

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24249082, KAKENHI-PROJECT-17K08146, KAKENHI-PROJECT-17H06276, KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16H05151
  • [Journal Article] A Trace Amount of Galactose, a Major Component of Milk Sugar, Allows Maturation of Glycoproteins during Sugar Starvation.2018

    • Author(s)
      Sasaoka Norio、Imamura Hiromi、Kakizuka Akira
    • Journal Title

      iScience

      Volume: 10 Pages: 211-221

    • DOI

      10.1016/j.isci.2018.11.035

    • NAID

      120006715477

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17H03654, KAKENHI-PROJECT-16H05151
  • [Journal Article] In vivo targeted single-nucleotide editing in zebrafish2018

    • Author(s)
      Tanaka, S., Yoshioka, S., Nishida, K., Hosokawa, H., Kakizuka, A., and Maegawa, S.
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 11423-11423

    • DOI

      10.1038/s41598-018-29794-9

    • NAID

      120006510277

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18J14073, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-17H04994
  • [Journal Article] The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation.2018

    • Author(s)
      Nie Xiang、Kitaoka Shiho、Tanaka Kohei、Segi-Nishida Eri、Imoto Yuki、Ogawa Atsubumi、Nakano Fumitake、Tomohiro Ayaka、Nakayama Kazuki、Taniguchi Masayuki、Mimori-Kiyosue Yuko、Kakizuka Akira、Narumiya Shuh、Furuyashiki Tomoyuki
    • Journal Title

      Neuron

      Volume: 99 Pages: 464-479

    • DOI

      10.1016/j.neuron.2018.06.035

    • NAID

      120006541943

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08316, KAKENHI-PROJECT-17K08593, KAKENHI-PUBLICLY-17H05572, KAKENHI-PUBLICLY-17H06057, KAKENHI-PROJECT-17H01531, KAKENHI-PROJECT-16H05132, KAKENHI-PROJECT-17J09360, KAKENHI-PROJECT-17K19457, KAKENHI-PROJECT-20K20379, KAKENHI-PROJECT-16H05151
  • [Journal Article] KUS121, a VCP modulator, attenuates ischemic retinal cell death viasuppressing endoplasmic reticulum stress.2017

    • Author(s)
      Hata, M., Yoshimura, N., et al.
    • Journal Title

      Scientific reports

      Volume: - Pages: 44873-44873

    • DOI

      10.1038/srep44873

    • NAID

      120006222005

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20255, KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-16K20316, KAKENHI-PROJECT-24249082, KAKENHI-PUBLICLY-16H01359
  • [Journal Article] ATP Maintenance via Two Types of ATP Regulators Mitigates Pathological Phenotypes in Mouse Models of Parkinson's Disease.2017

    • Author(s)
      Nakano Masaki、Imamura Hiromi、Sasaoka Norio、Yamamoto Masamichi、Uemura Norihito、Shudo Toshiyuki、Fuchigami Tomohiro、Takahashi Ryosuke、Kakizuka Akira
    • Journal Title

      EBioMedicine.

      Volume: 22 Pages: 225-241

    • DOI

      10.1016/j.ebiom.2017.07.024

    • NAID

      120006338063

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07036, KAKENHI-PROJECT-16K14709, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-17H03654
  • [Journal Article] ATP制御によるパーキンソン病の予防・治療戦略2017

    • Author(s)
      垣塚 彰
    • Journal Title

      日本生物学的精神医学会誌

      Volume: 28 Pages: 153-158

    • NAID

      130007685015

    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Journal Article] A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs2017

    • Author(s)
      Konagaya Y., Terai K., Hirao Y., Takakura K., Imajo M., Kamioka Y., Sasaoka N., Kakizuka A., Sumiyama K., Asano T., Matsuda M.
    • Journal Title

      Cell Reports

      Volume: 21 Pages: 2628-2638

    • DOI

      10.1016/j.celrep.2017.10.113

    • NAID

      120006366781

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K21106, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-16H06280
  • [Journal Article] Neurprotective efficacies by KUS121, a VCP modulator, on animal models of retinal degeneration.2016

    • Author(s)
      Hasegawa, T. Yoshimura, N., et al.
    • Journal Title

      Scientific reports

      Volume: 6 Pages: 31184-31184

    • DOI

      10.1038/srep31184

    • NAID

      120005829364

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04994, KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-24249082, KAKENHI-PUBLICLY-16H01359
  • [Journal Article] Neuroprotective effects of VCP modulators in mouse models of glaucoma.2016

    • Author(s)
      Nakano, N., Yoshimura, N., et al.
    • Journal Title

      Heliyon

      Volume: 2 Pages: 96-96

    • DOI

      10.1016/j.heliyon.2016.e00096

    • NAID

      120005753824

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01181, KAKENHI-PROJECT-15K15633, KAKENHI-PROJECT-16K11285, KAKENHI-PROJECT-16H05151, KAKENHI-PROJECT-24249082, KAKENHI-PUBLICLY-16H01359
  • [Journal Article] BTeam: A novel BRET-based biosensor for the accurate quantification of ATP concentration within living cells.2016

    • Author(s)
      Yoshida T, Kakizuka A, Imamura H.
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 39618-39618

    • DOI

      10.1038/srep39618

    • NAID

      120005947215

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-15H01181, KAKENHI-PUBLICLY-15H01401, KAKENHI-PROJECT-26291027, KAKENHI-PROJECT-16K14709
  • [Journal Article] VCP/Cdc48 rescues the growth defect of a GPI10 mutant in yeast2016

    • Author(s)
      Ohnuma, Y., Takata, T., Kawawaki, J., Yasuda, K., Tanaka, K., Kimura, Y., and Kakizuka A.
    • Journal Title

      FEBS Lett.

      Volume: 589 Pages: 576-580

    • DOI

      10.1016/j.febslet.2015.01.017

    • NAID

      120005531440

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249082, KAKENHI-PROJECT-26440070, KAKENHI-PROJECT-26000014
  • [Journal Article] Coordinated regulation of TIP60 and PARP-1 in damaged chromatin dynamics2016

    • Author(s)
      Ikura M
    • Journal Title

      Mol. Cel. Biol.

      Volume: Epub ahead of print Pages: 1595-1607

    • DOI

      10.1128/mcb.01085-15

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K12203, KAKENHI-PUBLICLY-15H01181, KAKENHI-PROJECT-23221006, KAKENHI-PROJECT-26550028, KAKENHI-PROJECT-26281020
  • [Journal Article] Glucose-stimulated Single Pancreatic Islets Sustain Increased Cytosolic ATP Levels during Initial Ca2+ Influx and Subsequent Ca2+ Oscillations.2014

    • Author(s)
      Tanaka T, Nagashima K, Inagaki N, Kioka H, Takashima S, Fukuoka H, Noji H, Kakizuka A and Imamura H
    • Journal Title

      J Biol Chem.

      Volume: 289 Pages: 2205-16

    • DOI

      10.1074/jbc.m113.499111

    • NAID

      120005689188

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25461346, KAKENHI-PLANNED-26111004
  • [Journal Article] Diversity in ATP concentrations in a single bacterial cell population revealed by quantitative single-cell imaging.2014

    • Author(s)
      Hideyuki Yaginuma, Shinnosuke Kawai, Kazuhito V. Tabata, Keisuke Tomiyama, Akira Kakizuka, Tamiki Komatsuzaki, Hiroyuki Noji, and Hiromi Imamura
    • Journal Title

      Science Report

      Volume: 4 Pages: 6522-6522

    • DOI

      10.1038/srep06522

    • NAID

      120005575159

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-23115002, KAKENHI-PLANNED-23115007, KAKENHI-PROJECT-24249082, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25287105, KAKENHI-PROJECT-25650044, KAKENHI-PROJECT-26291027, KAKENHI-PROJECT-26252064
  • [Journal Article] Novel vcp modulators mitigate major pathologies of rd10, a mouse model of retinitis pigmentosa.2014

    • Author(s)
      Ikeda, H. O., Sasaoka, N., Koike, M., Nakano, N., Muraoka, Y., Toda, Y., Fuchigami, T., Shudo, T., Iwata, A., Hori, S., Yoshimura, N. & Kakizuka, A.
    • Journal Title

      Sci Rep

      Volume: 4 Pages: 5970-5970

    • DOI

      10.1038/srep05970

    • NAID

      120005464816

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Journal Article] Long-term oral administration of hop flower extracts mitigates Alzheimer phenotypes in mice.2014

    • Author(s)
      Sasaoka N, Sakamoto M, Kanemori S, Kan M, Tsukano C, Takemoto Y, Kakizuka A.
    • Journal Title

      PLoS One

      Volume: 9

    • DOI

      10.1371/journal.pone.0087185

    • NAID

      120005367799

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Journal Article] In vivo fluorescent ATP imaging of Drosophila melanogaster and Caenorhabditis elegans by using a genetically encoded fluorescent ATPbiosensor optimized for low temperatures2013

    • Author(s)
      Tsuyama, Taiichi; Kishikawa, Jun-ichi; Han, Yong-Woon; Harada, Yoshie; Tsubouchi, Asako; Noji, Hiroyuki; Kakizuka, Akira; Yokoyama, Ken; Uemura, Tadashi; Imamura, Hiromi.
    • Journal Title

      Anal Chem.

      Volume: 85(16) Pages: 7889-7896

    • DOI

      10.1021/ac4015325

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-22115006, KAKENHI-PLANNED-23115002, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-24657101, KAKENHI-PROJECT-25251016, KAKENHI-PROJECT-25440008
  • [Journal Article] VCP Is an Integral Component of a Novel Feedback Mechanism that Controls Intracellular Localization of Catalase and H2O2 Levels.2013

    • Author(s)
      Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, Kakizuka A.
    • Journal Title

      PLoS One

      Volume: 8

    • DOI

      10.1371/journal.pone.0056012

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Journal Article] Prostaglandin E receptor EP1 forms a complex with dopamine D1 receptor and directs D1-induced cAMP production to adenylyl cyclase 7 through mobilizing Gβγ subunits in human embryonic kidney 293T cells.2013

    • Author(s)
      Ehrlich AT, Furuyashiki T, Kitaoka S, Kakizuka A, Narumiya S.
    • Journal Title

      Molecular Pharmacology

      Volume: 84 Pages: 476-486

    • DOI

      10.1124/mol.113.087288

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-24689015, KAKENHI-PUBLICLY-25116517, KAKENHI-PUBLICLY-25116715
  • [Journal Article] Mdm20 Stimulates PolyQ Aggregation via Inhibiting Autophagy Through Akt-Ser473 Phosphorylation.2013

    • Author(s)
      Yasuda K, Ohyama K, Onga K, Kakizuka A, Mori N
    • Journal Title

      PLoS One.

      Volume: 16;8(12):e82523 Pages: 1-15

    • DOI

      10.1371/journal.pone.0082523

    • NAID

      120006986747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22300121, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-24650200
  • [Journal Article] Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system.2013

    • Author(s)
      Yoko Kimura, Junpei Fukushi, Seiji Hori, Noriyuki Matsuda, Kei Okatsu, Yukie Kakiyama, Junko Kawawaki, Akira Kakizuka, Keiji Tanaka
    • Journal Title

      Genes Cells.

      Volume: 18 Pages: 1131-1143

    • DOI

      10.1111/gtc.12103

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-11J06061, KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-23570184
  • [Journal Article] 神経変性と細胞死2013

    • Author(s)
      垣塚 彰
    • Journal Title

      医学のあゆみ

      Volume: 246 Pages: 449-454

    • Data Source
      KAKENHI-PROJECT-23249016
  • [Journal Article] Real-time imaging of rabbit retina with retinal degeneration by using spectral-domain optical coherence tomography2012

    • Author(s)
      Muraoka Y et al.
    • Journal Title

      PLoS ONE

      Volume: 7

    • DOI

      10.1371/journal.pone.0036135

    • NAID

      120004108231

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23249016, KAKENHI-PROJECT-23390401, KAKENHI-PROJECT-23592603, KAKENHI-PROJECT-24249082, KAKENHI-PROJECT-24791850
  • [Journal Article] Maintaining ATP levels via the suppression of PERK-mediated rRNA synthesis at ER stress.2010

    • Author(s)
      Okamoto, A., Koike, M., Yasuda, K., Kakizuka A.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Pages: 42-47

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Valosin-containing protein (VCP) in novel feedback machinery between abnormal protein accumulation and transcriptional suppression.2010

    • Author(s)
      Koike M, Fukushi J, Ichinohe Y, Higashimae N, Fujishiro M, Sasaki C, Yamaguchi M, Uchihara T, Yagishita S, Ohizumi H, Hori S, Kakizuka A.
    • Journal Title

      J Biol Chem. (In press)

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Glucosamine induces autophagy via an mTOR-independent pathway.2010

    • Author(s)
      Shintani, T., Yamazaki, F., Katoh, T., Umekawa, M., Matahira, Y., Hori, S., Kakizuka, A., Totani, K., Yamamoto, K., Ashida, H.
    • Journal Title

      Biochem. Biophys. Res. Commun. 391

      Pages: 1775-1779

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Enhanced ATPase activities as a primary defect of mutant valosin-containing proteins (VCPs) that cause inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia (IBMPFD).2010

    • Author(s)
      Manno, A., Noguchi, M., Fukushi, J., Motohashi, Y., Kakizuka, A.
    • Journal Title

      Genes Cells (in press)

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患とVCP2009

    • Author(s)
      垣塚彰
    • Journal Title

      Clinical Neuroscience 27

      Pages: 964-965

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] p97/valosine- containing protein (VCP) is highly modulated by phosphorylation and acetylation.2009

    • Author(s)
      Mori-Konya, C., Kato, N., Maeda, R., Yasuda, K., Higashimae, N., Noguchi, M., Koike, M., Kimura, Y., Ohizumi, H., Hori, S., Kakizuka, A.
    • Journal Title

      Genes Cells 14

      Pages: 483-497

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] An inhibitor of a deubiquitingating enzyme regulates ubiquitin homeostasis.2009

    • Author(s)
      Kimura Y, Yashiroda H, Kudo T, Koitabashi S, Murata S, Kakizuka A, Tanaka K.
    • Journal Title

      Cell 137

      Pages: 549-559

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患における異常タンパク質の凝集と除去に関与するVCP2009

    • Author(s)
      垣塚彰
    • Journal Title

      生体の科学 60

      Pages: 579-581

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] ヒトの分子生物学2009

    • Author(s)
      垣塚彰
    • Journal Title

      分子生物学第2版(編集:柳田光弘、西田栄介、野田亮)

      Pages: 261-273

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Listeria monocytogenes ActA-mediated escape from autophagic recognition.2009

    • Author(s)
      Yoshikawa, Y., Ogawa, M., Hain T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., Kakizuka, A., Sztul, E., Chakraborty, T., Sasakawa, C.
    • Journal Title

      Nat Cell Biol.

      Pages: 1233-1240

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Roles of VCP in human neurodegenerative disorders.2008

    • Author(s)
      Kakizuka A.
    • Journal Title

      Biochem. Soc. Trans. 36

      Pages: 105-10

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Roles of VCP in human neurodegenerative disorders.2008

    • Author(s)
      Kakizuka A.
    • Journal Title

      Biochem Soc Trans. 36

      Pages: 105-108

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma- aminobutyric acid receptor.2008

    • Author(s)
      Nomura, R., Suzuki, Y., Kakizuka, A., Jingami, H.
    • Journal Title

      J Biol Chem. 283

      Pages: 4665-4673

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Direct detection of the interaction between recombinantsoluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor.2008

    • Author(s)
      Nomura R, Suzuki Y, Kakizuka A, Jingami H.
    • Journal Title

      J Biol Chem. 283

      Pages: 4665-4673

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患に関わる蛋白質の種々の修飾2007

    • Author(s)
      垣塚 彰
    • Journal Title

      蛋白質・核酸・酵素 (印刷中)

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Involvement of valosin-containing protein(VCP)/p97 in the formation and clearance of abnormal protein aggregates.2007

    • Author(s)
      Kobayashi T, Manno A, Kakizuka A.
    • Journal Title

      Genes Cells 12

      Pages: 889-901

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患に関わる蛋白質の種々の修飾2007

    • Author(s)
      垣塚 彰
    • Journal Title

      蛋白質・核酸・酵素 (印刷中)

    • Data Source
      KAKENHI-PROJECT-17028028
  • [Journal Article] Involvement of valosin-containing protein (VCP)/p97 in the formation and clearance of abnormal protein aggregates.2007

    • Author(s)
      Kobayashi, T., Manno, A., Kakizuka, A.
    • Journal Title

      Genes Cells. 12

      Pages: 889-901

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患にかかわる蛋白質の種々の修飾2007

    • Author(s)
      垣塚 彰、小池雅昭
    • Journal Title

      蛋白質・核酸・酵素 52

      Pages: 768-773

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] In vivo analysis of the role of aberrant histone deacetylase recruitment and RAR alpha blockade in the pathogenesis of acute promyelocytic leukemia.2006

    • Author(s)
      Matsushita, H., Scaglioni, P.P., Bhaumik, M., Rego, E.M., Cai, L. F, Majid, S.M., Miyachi, H., Kakizuka, A., Miller, W.H. Jr., Pandolfi, P.P.
    • Journal Title

      J Exp Med. 203

      Pages: 821-828

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Dominant-negative effect of mutant valosin-containing protein in aggresome formation.2006

    • Author(s)
      Kitami, M.I., Kitami, T., Nagahama, M., Tagaya, M., Hori, S., Kakizuka, A., Mizuno, Y., Hattori, N.
    • Journal Title

      FEBS Lett. 580

      Pages: 474-478

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患と小胞体ストレス2006

    • Author(s)
      野口昌克, 垣塚 彰
    • Journal Title

      医学のあゆみ vol.216

      Pages: 4033-4039

    • Data Source
      KAKENHI-PROJECT-17028028
  • [Journal Article] 神経変性疾患と小胞体ストレス2006

    • Author(s)
      野口昌克, 垣塚 彰
    • Journal Title

      医学のあゆみ vol.216

      Pages: 4033-4039

    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Dominant-negative effect of mutation valosin-containing protein in aggresome formation.2006

    • Author(s)
      Kitami, MI., Kitami, T., Nagahama, M., Tagaya, M., Hori, S., Kakizuka, A., Mizuno, Y., Hattori, N.
    • Journal Title

      FEBS Lett. 580

      Pages: 474-478

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] PGC 1ファミリーと糖・脂質代謝2006

    • Author(s)
      大泉 宏, 垣塚 彰
    • Journal Title

      内分泌・糖尿病科 23

      Pages: 40-47

    • Data Source
      KAKENHI-PROJECT-17028028
  • [Journal Article] 神経変性疾患と小胞体ストレス2006

    • Author(s)
      野口昌克, 垣塚 彰
    • Journal Title

      医学のあゆみ 216

      Pages: 4033-4039

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] 神経変性疾患と核2006

    • Author(s)
      垣塚 彰
    • Journal Title

      蛋白質・核酸・酵素 51

      Pages: 2269-2273

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患と小胞体ストレス2006

    • Author(s)
      野口昌克, 垣塚 彰
    • Journal Title

      医学のあゆみ vol.216

      Pages: 4033-4039

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] PGC 1ファミリーと糖・脂質代謝2006

    • Author(s)
      大泉 宏, 垣塚 彰
    • Journal Title

      内分泌・糖尿病科 23

      Pages: 40-47

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] 神経変性疾患と核2006

    • Author(s)
      垣塚 彰
    • Journal Title

      蛋白質・核酸・酵素 51

      Pages: 2269-2273

    • Data Source
      KAKENHI-PROJECT-17028028
  • [Journal Article] Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-xL.2006

    • Author(s)
      Chou, A.H., Yeh, T.H., Kuo, Y.L., Kao, Y.C., Jou, M.J., Hsu, C.Y., Tsai, S.R., Kakizuka, A., Wang, H.L.
    • Journal Title

      Neurobiol Dis. 21

      Pages: 333-345

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] In vivo analysis of the role of aberrant histone deacetylase recruitment and RARα blockade in the pathogenesis of acute promyelocytic leukemia.2006

    • Author(s)
      Matsushita, H., Scaglioni, P.P., Bhaumik, M., Rego, E.M/, Cai, L.F., Majid, S.M., Miyachi, H., Kakizuka, A., Miller, W.H.Jr., Pandolfi, P.P.
    • Journal Title

      J.ExP.Med. 203

      Pages: 821-828

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] ポリグルタミン病2005

    • Author(s)
      垣塚 彰
    • Journal Title

      脳神経外科速報 15

      Pages: 543-549

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon.2005

    • Author(s)
      Liao, W.L., Wang, H.F., Tsai, H.C., Chambon, P., Wagner, M., Kakizuka, A., Liu, F.C.
    • Journal Title

      Dev Dyn. 232

      Pages: 887-900

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] - alpha, beta -unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor gamma.2005

    • Author(s)
      Shiraki, T., Kamiya, N., Shiki, S., Kodama, T.S., Kakizuka, A., Jingami, H.
    • Journal Title

      J. Biol. Chem. 279

      Pages: 51376-51385

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] ATPase activity of Valosin-containing protein (VCP) is regulated by oxidative modification of the evolutionally conserved 522nd cysteine residue in Walker A motif.2005

    • Author(s)
      Noguchi, M., Takata, T. Kimura, Y., Manno, A., Murakami, K., Koike, M., Ohizumi, H., Hori, S., Kakizuka A.
    • Journal Title

      J. Biol. Chem. 280

      Pages: 41332-41341

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Retinoid signaling competence and RARbeta-mediated gene regulation in the developing mammalian telencephalon.2005

    • Author(s)
      Liao, W.L., Wang, H.F., Tsai, H.C., Chambon, P., Wagner, M., Kakizuka, A., Liu, F.C.
    • Journal Title

      Dev. Dyn. 232

      Pages: 887-900

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] ポリグルタミン病2005

    • Author(s)
      垣塚 彰
    • Journal Title

      脳神経外科速報 vol.15

      Pages: 543-549

    • Data Source
      KAKENHI-PROJECT-17028028
  • [Journal Article] α, β-unsaturated ketone is a core moiety of natural ligands for covalent binding to peroxisome proliferator-activated receptor γ.2005

    • Author(s)
      Shiraki, T., Kamiya, N., Shiki, S., Kodama, T.S., Kakizuka, A., Jingami, H.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 51376-51385

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor α.2005

    • Author(s)
      Wang, Y.A., Sheng, K., Ishida, Y., Wang, Y., Kakizuka, A., Brooks, S.C.
    • Journal Title

      Mol.Carcinog. 44

      Pages: 252-261

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] ポリグルタミン病2005

    • Author(s)
      垣塚 彰
    • Journal Title

      脳神経外科速報 vol.15

      Pages: 543-549

    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] ATPase activity of p97/Valosin-containing protein (VCP) is regulated by oxidative modification of the evolutionally conserved cysteine 522 residue in Walker A motif.2005

    • Author(s)
      Noguchi, M., Takata, T., Kimura, Y., Manno, A., Murakami, K., Koike, M., Ohizumi, H., Hori, S., Kakizuka A.
    • Journal Title

      J.Biol.Chem. 280

      Pages: 41332-41341

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] ポリグルタミン病2005

    • Author(s)
      垣塚 彰
    • Journal Title

      脳神経外科速報 vol.15

      Pages: 543-549

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Induction of murine leukemia and lymphoma by dominant negative retinoic acid receptor alpha.2005

    • Author(s)
      Wang, Y.A., Shen, K., Ishida, Y., Wang, Y., Kakizuka, A., Brooks, S.C.
    • Journal Title

      Mol Carcinog. 44

      Pages: 252-261

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] Polyglutamine-expanded ataxin-3 activates mitochondrial apoptotic pathway by upregulating Bax and downregulating Bcl-x(L).2005

    • Author(s)
      Chou, A.H., Yeh, T.H., Kuo, Y.L., Kao, Y.C., Jou, M.J., Hsu, C, Y., Tsai, S.R., Kakizuka, A., Wang, H.L.
    • Journal Title

      Neurobiol Dis. 21

      Pages: 333-345

    • Data Source
      KAKENHI-PROJECT-17014043
  • [Journal Article] The role of preexisting aggregates in Hsp104-dependent polyglutamine aggregate formation and epifenetic change of yeast prion2004

    • Author(s)
      Kimura, Y., Koitabshi, S., Kakizuka, A., Fujita, T.
    • Journal Title

      Genes to Cells 9

      Pages: 685-696

    • Data Source
      KAKENHI-PROJECT-16015338
  • [Journal Article] A mutant ataxin-3 putative-cleavage fragment in brain of Machado-Joseph disease patients and transgenic mice is cytotoxic above a critical concentration.2004

    • Author(s)
      Goti, D., Katzen S.M., Mez, J., Kurtis, N., Kiluk, J., Ben-Haiem, L., Jenkins, N.A, Copeland, N.G., Kakizuka, A., Sharp, A.H., Ross, C.A., Mouton, P.R., Colmer V.
    • Journal Title

      J.Neuroscience 24

      Pages: 10266-10279

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Molecular clearance of ataxin-3 is regulated by a mammalian E4.2004

    • Author(s)
      Matsumoto, M., Yada, M., Hatakeyama, H., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M., Nakayama, K.I.
    • Journal Title

      EMBO J. 23

      Pages: 659-669

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] 肥満のモデル動物-新たな抗肥満モデル,ERRL1マウス2004

    • Author(s)
      亀井康富, 垣塚 彰
    • Journal Title

      現代医療 36

      Pages: 99-104

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Effective treatment of advanced solid tumors by the combination of Arsenic Trioxide and L-Buthionine-Sulfoximine.2004

    • Author(s)
      Maeda, H., Hori, S., Ohizumi, H., Segawa, T., Kakehi, Y., Ogawa, O., Kakizuka, A.
    • Journal Title

      Cell Death Differ. 7

      Pages: 737-746

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Alteration in the cellular response to retinoic acid of a human acute promyelocytic leukemia cell line, UF-1, carrying a patient-derived mutant PML-RARα chimeric gene.2004

    • Author(s)
      Sato, A., Imaizumi, M., Hoshi, Y., Rikiishi, T., Fujii, K., Kizaki, M., Kagechika, H., Kakizuka, A., Hayashi, Y., Iinuma K.
    • Journal Title

      Leukemia Res. 9

      Pages: 959-967

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] コンフォメーション病2004

    • Author(s)
      垣塚 彰
    • Journal Title

      細胞工学 23

      Pages: 1394-1399

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] ポリグルタミン病における創薬標的2004

    • Author(s)
      堀 清次, 垣塚 彰
    • Journal Title

      蛋白質・核酸・酵素 49

      Pages: 1118-1121

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] フォールディング病としての神経変性疾患とオルガネラ病2004

    • Author(s)
      垣塚 彰, 森 正敏
    • Journal Title

      蛋白質・核酸・酵素 49

      Pages: 1077-1085

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] 神経変性疾患と細胞死2004

    • Author(s)
      垣塚 彰
    • Journal Title

      実験医学 22

      Pages: 134-139

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] The role of pre-existing aggregates in Hsp 104-dependent polyglutamine aggregate formation and epigenetic change of yeast prions.2004

    • Author(s)
      Kimura, Y., Koitabashi, S., Kakizuka, A., Fujita, T.
    • Journal Title

      Genes Cells 8

      Pages: 685-696

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Physical and functional interaction between dorfin and valosin-containing protein that are colocalized in ubiquitylated inclusions in neurodegenerative disorders.2004

    • Author(s)
      Ishigaki, S., Hishikawa, N., Niwa, J., Iemura, S., Natsume, T., Hori, S., Kakizuka, A., Tanaka, K., Sobue, G.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 51376-51385

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] 小胞体ストレスと神経変性疾患2004

    • Author(s)
      野口昌克, 垣塚 彰
    • Journal Title

      Clinical Neurosicence 月刊 臨床神経科学 22

      Pages: 1046-1051

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16390092
  • [Journal Article] Polyglutamine diseases and molecular chaperones.2003

    • Author(s)
      Kimura, Kakizuka.
    • Journal Title

      IUBMB Life. 55

      Pages: 337-345

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13210155
  • [Patent] 心筋細胞の保護用の医薬組成物2019

    • Inventor(s)
      垣塚彰、尾野亘、堀江貴裕、井手裕也、斉藤成達、木村剛
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Overseas
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Patent] 心筋細胞の保護用の医薬組成物2018

    • Inventor(s)
      垣塚彰、尾野亘、堀江貴裕、井手裕也、斉藤成達、木村剛
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-078272
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Patent] 心筋細胞の保護用の医薬組成物2018

    • Inventor(s)
      垣塚彰、尾野亘、堀江貴弘、木村剛
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-078272
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Patent] 脳梗塞の処置用の医薬組成物2018

    • Inventor(s)
      垣塚彰、木下久徳、眞木崇州、高橋良輔
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-143437
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Patent] 角膜保護用の組成物2017

    • Inventor(s)
      池田華子、垣塚彰、木下茂、中村隆宏、永田真帆、他2名
    • Industrial Property Rights Holder
      国立大学法人京都大学、京都府公立大学法人、学校法人同志社
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2017-251839
    • Filing Date
      2017
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Patent] 虚血性眼疾患の処置および/または予防用の医薬組成物2015

    • Inventor(s)
      垣塚彰、池田華子、吉村長久, 他1名
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Filing Date
      2015-02-26
    • Description
      特願2014-038457
    • Overseas
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Patent] 眼疾患処置薬2014

    • Inventor(s)
      垣塚彰、池田華子、吉村長久, 他1名
    • Industrial Property Rights Holder
      国立大学法人京都大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-19
    • Acquisition Date
      2017-12-22
    • Description
      米国 : 9782120 日本特許登録 : 6261011 2017/10/10
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Patent] 虚血性眼疾患の処置および/または予防用の医薬組成物2014

    • Inventor(s)
      垣塚 彰、池田華子、吉村長久、畑匡侑
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-038457
    • Filing Date
      2014-02-28
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] 眼疾患処置薬2014

    • Inventor(s)
      垣塚 彰、池田華子、吉村長久、村岡勇貴
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2014-02-19
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] 加齢黄斑変性予防・治療薬2013

    • Inventor(s)
      垣塚 彰、堀 清次、池田華子、吉村長久、他3名
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-221873
    • Filing Date
      2013-02-20
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] PCT出願2011

    • Inventor(s)
      垣塚彰, 他
    • Industrial Property Rights Holder
      京都大学, 他
    • Filing Date
      2011-09-30
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] 特許出願2011

    • Inventor(s)
      垣塚彰, 他
    • Industrial Property Rights Holder
      京都大学
    • Industrial Property Number
      2011-019043
    • Filing Date
      2011-09-01
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] PCT出願2011

    • Inventor(s)
      垣塚彰, 他
    • Industrial Property Rights Holder
      京都大学, 他
    • Filing Date
      2011-07-28
    • Overseas
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] 眼疾患処置薬2011

    • Inventor(s)
      垣塚彰、堀清次、池田華子、吉村長久, 他3名
    • Industrial Property Rights Holder
      国立大学法人京都大学、他一社
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-09-30
    • Acquisition Date
      2015-10-16
    • Description
      イギリス : 2623494 フランス : 2623494 米国 : 920619
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Patent] 特許出願2011

    • Inventor(s)
      垣塚彰, 他
    • Industrial Property Rights Holder
      京都大学, 他
    • Industrial Property Number
      2011-102330
    • Filing Date
      2011-04-28
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Patent] ペルオキシゾーム増殖剤応答性受容体活性剤および組成物2008

    • Inventor(s)
      垣塚彰、大滝佳代、大泉宏、庭野吉己、別府史章、鈴木尚志
    • Industrial Property Rights Holder
      京都大学、(株)サニーヘルス
    • Industrial Property Number
      2008-227635
    • Filing Date
      2008-09-04
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Patent] 蛋白質切断活性を有する細胞のスクリーニング方法2007

    • Inventor(s)
      垣塚彰、山本幸男
    • Industrial Property Rights Holder
      JST
    • Acquisition Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Patent] 蛋白質切断活性を有する細胞のスクリーニング方法2007

    • Inventor(s)
      垣塚彰、山本幸男
    • Industrial Property Rights Holder
      JST
    • Acquisition Date
      2007-11-02
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 難治性疾患への挑戦2020

    • Author(s)
      垣塚 彰
    • Organizer
      東海医学会講演会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03435
  • [Presentation] 難治性疾患克服への挑戦2019

    • Author(s)
      垣塚 彰
    • Organizer
      第21回生命科学研究科シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03435
  • [Presentation] 難治性疾患の克服への挑戦2018

    • Author(s)
      垣塚彰
    • Organizer
      京都大学第2回創薬医療シンポジウム、第5回バイオ・フロンティア・プラットフォームシンポジウム「オープンイノベーションから創薬へ」
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Presentation] 難病への挑戦:Challenges against incurable diseases2017

    • Author(s)
      垣塚 彰
    • Organizer
      第19回 京都大学生命科学研究科シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Presentation] ATP制御による包括的な疾患の予防・治療戦略:Comprehensive therapeutic strategies for diseases by ATP regulations2017

    • Author(s)
      垣塚 彰
    • Organizer
      第90回日本生化学会大会(2017年度生命科学系学会合同年次大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Presentation] ATP制御による難治性疾患の予防・治療戦略2016

    • Author(s)
      垣塚 彰
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01181
  • [Presentation] プロテアゾーム阻害下におけるユヒキチン化蛋白質の消失機構の解析2016

    • Author(s)
      垣塚 彰
    • Organizer
      平成 28 年度 科学研究費補助金 新学術領域研究 「ユヒキチンネオバイオロジー」班会議
    • Place of Presentation
      シャトレーゼ ガトーキングダムサッポロ(札幌市)
    • Data Source
      KAKENHI-PUBLICLY-15H01181
  • [Presentation] ATP制御による難治性疾患の予防・治療戦略2016

    • Author(s)
      垣塚 彰
    • Organizer
      第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05151
  • [Presentation] プロテアゾーム阻害下におけるユビキチン化蛋白質の除去機構の解析2015

    • Author(s)
      垣塚彰
    • Organizer
      新学術領域「ユビキチンネオバイオロジー」平成27年度領域班会議
    • Place of Presentation
      南房総富浦ロイヤルホテル(千葉県・南房総市)
    • Year and Date
      2015-12-18
    • Data Source
      KAKENHI-PUBLICLY-15H01181
  • [Presentation] VCP modulatorのCCR2欠損マウスにおけるドルーゼン抑制の機序2015

    • Author(s)
      飯田悠人、池田華子、吉川宗光、畑匡侑、長谷川智子、村岡勇貴、垣塚彰、吉村長久
    • Organizer
      119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌ほか(札幌市)
    • Year and Date
      2015-04-16
    • Data Source
      KAKENHI-PROJECT-15K15633
  • [Presentation] プロテアゾーム阻害下におけるユビキチン化蛋白質の除去機構の解明に向けて2015

    • Author(s)
      垣塚彰
    • Organizer
      新学術領域「ユビキチンネオバイオロジー」平成27年度 若手ワークショップ・第一回領域会議
    • Place of Presentation
      アピカルイン京都(京都府・京都市)
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PUBLICLY-15H01181
  • [Presentation] ATP制御による難治性疾患の病態とゲノムストレスの軽減の可能性2015

    • Author(s)
      垣塚彰
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-12-04
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01181
  • [Presentation] Neuroprotective effect of a valosin-containing-protein ATPase inhibitor on late-stage retinal degeneration in a mouse model.2014

    • Author(s)
      Tomoko Hasegawa, Hanako O. Ikeda, Yuki Muraoka1,Akira Kakizuka,Nagahisa Yoshimura.
    • Organizer
      World Ophthalmology Congress
    • Place of Presentation
      Japan, Tokyo
    • Year and Date
      2014-04-05
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] Optical coherence tomography, electroretinography, and histological analysis of mouse models for retinal degeneration2013

    • Author(s)
      Tomoko HasegawaHanako Ohashi Ikeda,1 Noriko Nakano,1 Yuki Muraoka,1 Akira Kakizuka,4 Nagahisa Yoshimura1
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] Novel VCP inhibitors mitigate major pathologies in mouse models of glaucoma and retinitis pigmentosa by their neuroprotective effects.2013

    • Author(s)
      Akira Kakizuka
    • Organizer
      EMBO workshop “AAA+ proteins: from mechanism and disease targets”
    • Place of Presentation
      Neuss (Germanry)
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] VCP 阻害剤によるCCR2欠損マウスのドルーゼン抑制効果の検討2013

    • Author(s)
      村岡勇貴、池田華子、中野紀子、長谷川智子、垣塚彰、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] 新規創薬標的としての細胞内主要ATPase、VCP2013

    • Author(s)
      垣塚 彰
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] VCP阻害剤による網膜神経保護効果のメカニズム2013

    • Author(s)
      池田華子、中野紀子、村岡勇貴、長谷川智子、垣塚彰、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] VCP阻害剤によるグラスト欠損マウスにおける 神経保護効果の検討2013

    • Author(s)
      中野紀子、池田華子、村岡勇貴、板谷正紀、垣塚彰、吉村長久
    • Organizer
      日本眼科学会117回
    • Place of Presentation
      東京国際フォーラム
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] 新規神経保護創薬標的としての細胞内主要ATPase、VCP2013

    • Author(s)
      垣塚 彰
    • Organizer
      「病態に根ざしたALSの新規治療法開発」分科班 平成25年度ワークショップ
    • Place of Presentation
      都市センターホテル
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] A Novel Valosin-Containing Protein Inhibitor Suppresses Photoreceptor Degeneration in a Rabbit Model of Retinitis Pigmentosa2013

    • Author(s)
      Yuki Muraoka,1 Hanako Ohashi Ikeda,1 Noriko Nakano,1 Tomoko Hasegawa,1 Kondo Mineo,2 Hiroko Terasaki,3 Akira Kakizuka,4 Nagahisa Yoshimura1
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] Neuroprotective effect of valosin-containing protein inhibitors on mice models of glaucoma2013

    • Author(s)
      Hanako Ohashi Ikeda、Noriko Nakano,Yuki Muraoka, Masanori Hangai, Akira Kakizuka, Nagahisa Yoshimura
    • Organizer
      ARVO 2013
    • Place of Presentation
      Seattle
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] 新規創薬標的としての細胞内主要ATPase、VCP2013

    • Author(s)
      垣塚 彰
    • Organizer
      第22回日本Cell Death学会学術集会
    • Place of Presentation
      京都大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] Trials for the prevention of incurable disease models by the regulation of ATP2013

    • Author(s)
      垣塚 彰
    • Organizer
      京都大学生命科学研究科シンポジウム
    • Place of Presentation
      京都大学
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] 新規創薬標的としての細胞内主要ATPase、VCP2013

    • Author(s)
      垣塚 彰
    • Organizer
      上原記念生命科学財団 特定研究助成 革新的医療を創生する医学研究
    • Place of Presentation
      下田セントラルホテル
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] VCP as a novel drug target for currently non-curable eye disorders2013

    • Author(s)
      Akira Kakizuka
    • Organizer
      BioJapan 2013
    • Place of Presentation
      パシフィコ横浜
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] 新規神経保護薬の開発とその緑内障動物モデルに対する応用2012

    • Author(s)
      垣塚 彰
    • Organizer
      第23回日本緑内障学会
    • Place of Presentation
      石川県立音楽堂
    • Invited
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] Roles of VCP in neurodegenerative disorders2012

    • Author(s)
      Akira Kakizuka
    • Organizer
      The 10th NTU-Japan International mini-symposium on Molecular and Cell biology & Promotion of Academic Exchange and Collaborations for NTU-Japan
    • Place of Presentation
      Taiwan National University (Taiwan)(招待講演)
    • Year and Date
      2012-01-08
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] 神経変性疾患およびストレス応答におけるVCPの役割2011

    • Author(s)
      垣塚彰
    • Organizer
      第20回日本Cell Death学会
    • Place of Presentation
      東京大学薬学講堂(東京)(招待講演)
    • Year and Date
      2011-07-30
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] VCPが関わる異常蛋白質に対するストレス応答機構とATP制御機構2011

    • Author(s)
      垣塚彰
    • Organizer
      第84回日本生化学会大会シンポジウム(2S2a)ストレスシグナル研究の最前線
    • Place of Presentation
      京都国際会議場(京都)(招待講演)
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] Roles of VCP in polyglutamine diseases2011

    • Author(s)
      Akira Kakizuka
    • Organizer
      Asian Aging Core for Longevity-Nagasaki Symposium Asian Aging 2011
    • Place of Presentation
      Nagasaki University (Japan)(招待講演)
    • Year and Date
      2011-11-21
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] Roles of VCP in abnormal phospholipid metabolisms in polyglutamine disease models2011

    • Author(s)
      Akira Kakizuka
    • Organizer
      9th International conference on AAA proteins
    • Place of Presentation
      Kumamoto City International Center (Japan)(招待講演)
    • Year and Date
      2011-11-10
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] 細胞内ATPの制御機構2011

    • Author(s)
      垣塚彰
    • Organizer
      第13回京都大学生命科学研究科シンポジウム
    • Place of Presentation
      芝蘭会館(京都)(招待講演)
    • Year and Date
      2011-07-08
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] Roles of VCP in human neurodegenerative disorders2011

    • Author(s)
      Akira Kakizuka
    • Organizer
      Kyoto University day in Nanjing
    • Place of Presentation
      Nanjing University (China)(招待講演)
    • Year and Date
      2011-12-02
    • Data Source
      KAKENHI-PROJECT-23249016
  • [Presentation] 細胞機能におけるVCP蛋白質の役割2009

    • Author(s)
      垣塚彰
    • Organizer
      第10回京都大学生命科学研究科シンポジウム
    • Place of Presentation
      京都大学芝蘭会館
    • Year and Date
      2009-07-02
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] ストレス応答におけるVCP蛋白質の役割2009

    • Author(s)
      垣塚彰
    • Organizer
      第82回日本生化学会シンポジウム「ストレス応答の新機軸」
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] A novel feedback machinery between abnormal protein accumulation and transcriptional suppression.2009

    • Author(s)
      Akira Kakizuka
    • Organizer
      The 5th NTU-Kyoto-U mini-symposium on molecular and cellular biology.
    • Place of Presentation
      Raku-yu Kaikan, Kyoto, Japan.
    • Year and Date
      2009-05-23
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 細胞周期におけるVCP/p97のリン酸化の役割の解析: Roles of VCP phosphorylation in cell cycle progression2009

    • Author(s)
      加藤成芳、村上克洋、紺谷千穂、堀清次、垣塚彰
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 細胞機能におけるVCP蛋白質の役割2009

    • Author(s)
      垣塚彰
    • Organizer
      第10回京都大学生命科学研究科シンポジウム
    • Place of Presentation
      芝蘭会館
    • Year and Date
      2009-07-02
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 癌ってどうゆうもの?2009

    • Author(s)
      垣塚彰
    • Organizer
      膳所高等学校・京都大学公開講義
    • Place of Presentation
      京都大学
    • Year and Date
      2009-05-08
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 酵母のGP110温度感受性変異株で見られる出芽阻害とDNA過剰複製: Budding defect and DNA over-replication in a yeast GP110 temperature-sensitive mutant2009

    • Author(s)
      大沼洋平、高田尚寛、安田邦彦、垣塚彰
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-23
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] p97/VCPのATPase活性に作用する新規翻訳後修飾の同定: Identification of novel post-translational modifications which affect the ATPase activity of p97/VCP2009

    • Author(s)
      紺谷千穂、加藤成芳、前田良太、小池雅昭、安田邦彦、野口昌克、東前直樹、木村洋子、大泉宏、堀清次、垣塚彰
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-22
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] ストレス応答におけるVCP蛋白質の役割, ストレス応答の新機軸2009

    • Author(s)
      垣塚彰
    • Organizer
      第82回日本生化学会シンポジウム
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2009-10-24
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 分子が織りなす生命の不思議-どうして病気になるの? 運動しても肥満は防げない? がん・神経難病、肥満・糖尿病をめぐって-2008

    • Author(s)
      垣塚彰
    • Organizer
      徳島県立総合大学校まなーびあ徳島開校記念講演
    • Place of Presentation
      徳島県立総合教育センター(徳島県板野郡)
    • Year and Date
      2008-06-08
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] VCPはペルオキシソームマトリックスタンパク質の輸送と分解に関与する : VCP is involved in peroxisomal matrix protein import and degradation2008

    • Author(s)
      村上克洋、垣塚彰
    • Organizer
      BMB2008
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-09
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] ヒト子宮頸癌及び食道癌におけるVCP co-factor p47の発現上昇による浸潤能の獲得 : Overexpression of p47, a VCP co-factor, in potential acquisition of invasion activities in human esophageal and cervical cancer2008

    • Author(s)
      一戸勇弦、東前直樹、大泉宏、垣塚彰
    • Organizer
      BMB2008
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-10
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 小胞体ストレスに対する新規応答機構 : Inhibition of rRNA synthesis in response to ER stress2008

    • Author(s)
      岡本暁彦、安田邦彦、垣塚彰
    • Organizer
      BMB2008
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2008-12-11
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 異常蛋白質の蓄積がもたらすフィードバック機構2008

    • Author(s)
      垣塚彰
    • Organizer
      第9回京都大学生命科学研究科シンポジウム
    • Place of Presentation
      京大会館
    • Year and Date
      2008-06-26
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 分子が織りなす生命の不思議-どうして病気になるの? 運動しても肥満は防げない? がん・神経難病、肥満・糖尿病をめぐって-2008

    • Author(s)
      垣塚彰
    • Organizer
      徳島県立総合大学校まな-びあ徳島開校記念講演
    • Place of Presentation
      徳島県立総合教育センター
    • Year and Date
      2008-06-08
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 癌ってどうゆうもの2007

    • Author(s)
      垣塚 彰
    • Organizer
      膳所高等学校・京都大学公開講義
    • Place of Presentation
      京都大学
    • Year and Date
      2007-04-27
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] Roles of VCP in human neurodegenerative disorders2007

    • Author(s)
      Kakizuka A.
    • Organizer
      7th international conference on AAA proteins
    • Place of Presentation
      Royal Agricultural College, Cirencester(England)
    • Year and Date
      2007-09-11
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] Roles of VCP in human neurodegenerative disorders2007

    • Author(s)
      Akira Kakizuka
    • Organizer
      7th international conference on AAA proteins.
    • Place of Presentation
      Royal Agricultural College, Cirencester (England)
    • Year and Date
      2007-09-11
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] VCP蛋白質の機能解析, 細胞死研究の新たな展開と関連する素過程2006

    • Author(s)
      垣塚彰
    • Organizer
      平成18年度生理学研究所研究会
    • Place of Presentation
      生理学研究所
    • Year and Date
      2006-10-31
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 「癌ってどういうもの?」文部科学省科学研究費補助金特定領域研究「がん特定」公開シンポジウム 「高校生の諸君に伝えたい、がん研究の今!」2006

    • Author(s)
      垣塚彰
    • Organizer
      第3回出前授業
    • Place of Presentation
      徳島県立城南高等学校
    • Year and Date
      2006-11-20
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] ATPase activity of Valosin-containing protein (VCP) is regulated by oxidative modification of the evolutionally conserved 522nd cysteine residue in Walker A motif2005

    • Author(s)
      Akira Kakizuka
    • Organizer
      6th international conference on AAA proteins.
    • Place of Presentation
      Schloss Seggau, Austria
    • Year and Date
      2005-09-15
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] 細胞周期におけるVCP蛋白質の機能解析2005

    • Author(s)
      垣塚彰
    • Organizer
      第78回日本生化学会大会ランチョンセミナー
    • Place of Presentation
      神戸ポートピアホテル
    • Year and Date
      2005-10-20
    • Data Source
      KAKENHI-PROJECT-17014043
  • [Presentation] Neuroprotective effects of a VCP modulator on rat models of ischemia and reperfusion-induced retinal degeneration

    • Author(s)
      Masayuki Hata, Hanako O. Ikeda, Tomoko Hasegawa, Noriko Nakano, Yuki Muraoka, Akira Kakizuka, Nagahisa Yoshimura
    • Organizer
      ARVO2014
    • Place of Presentation
      Orland, Fla., USA
    • Year and Date
      2014-05-04 – 2014-05-08
    • Data Source
      KAKENHI-PROJECT-24249082
  • [Presentation] 網膜虚血再灌流ラットモデルにおけるvalosin-containing protein modifierの神経保護効果の検討

    • Author(s)
      畑匡侑、池田華子、飯田悠人、吉川宗光、長谷川智子、村岡勇貴、垣塚彰、吉村長久
    • Organizer
      53回日本網膜硝子体学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2014-11-28 – 2014-11-30
    • Data Source
      KAKENHI-PROJECT-24249082
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  • 79.  渋谷 正史 (10107427)
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  • 80.  佐々木 卓也 (40241278)
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  • 84.  矢守 隆夫 (60200854)
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  • 88.  月田 承一郎 (50155347)
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  • 97.  張 祥華 (30274286)
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  • 98.  SYMONDS Marc
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  • 99.  VUORI Kristiina
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  • 116.  FURUYASHIKI Tomoyuki
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  • 119.  IKURA Masae
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  • 120.  岩井 祥子
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  • 121.  中尾 一和
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  • 122.  下澤 律浩
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  • 123.  岩田 岳
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  • 124.  上村 匡
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  • 125.  野地 博行
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  • 126.  韓 龍雲
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  • 127.  長嶋 一昭
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  • 128.  西田 敬二
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  • 129.  寺崎 浩子
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  • 130.  瀬木 恵里
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  • 131.  清末 優子
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  • 132.  山本 正道
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  • 133.  小松崎 民樹
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  • 134.  河合 信之輔
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  • 135.  近藤 峰生
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  • 136.  田中 啓二
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  • 137.  松田 由喜子
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  • 138.  井手 裕也
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  • 139.  森 望
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  • 140.  大山 恭司
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  • 141.  安田 邦彦
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  • 142.  井倉 毅
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  • 143.  松田 知成
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  • 144.  足立 淳
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  • 145.  今城 正道
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  • 146.  松田 道行
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    # of Collaborated Products: 1 results
  • 147.  青木 茂樹
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