ISHIZAKI Kanji 石崎寛治

… Alternative Names

石崎憲治イシザキケンジ

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Researcher Number	70111987
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2004 – 2005: 愛知県がんセンター(研究所), 中央実験部, 部長 2003: 愛知県がんセンター, 研究所・中央実験部, 部長 2002: 愛知県がんセンター, 中央実験部, 部長 2000: 愛知県がんセンター, 中央実験部, 部長 1994 – 1999: 愛知県がんセンター, 放射線部, 部長 … More 1995 – 1996: 愛知県がんセンター研究所, 放射線部, 部長 1994 – 1995: 愛知がんセンター研究所, 部長 1994 – 1995: 愛知県がんセンター研究所, 部長 1993: 放射線生物研究センター, 助教授 1989 – 1993: 京都大学, 放射線生物研究センター, 助教授 1990: 京都大学放射線生物研究センター, 助教授 1986 – 1989: Radiation Biology Center, Kyoto University, 放射線生物研究センター, 助手 1986: 京都大学, 放射線生物研究センター・放射線システム生物学研究部門, 助手 Less
Review Section/Research Field	Principal Investigator 環境影響評価(含放射線生物学) / Biological Sciences / Risk sciences of radiation/Chemicals / 放射線5生物学 Except Principal Investigator 放射線5生物学 / 環境影響評価(含放射線生物学) / Digestive surgery / Orthopaedic surgery
Keywords	Principal Investigator 突然変異 / PCR / 太陽紫外線 / DNA repair / SCE / DNA修復 / 食道がん / 環境変異源 / アルキル化剤耐性 / DNAミスマッチ修復 … More / 遺伝的不安定性 / 色素性乾皮症 / damage response / ATM protein / low-dose, low-dose-rate radiation / human cells / hTERT gene / p53遺伝子誘発 / 生存率 / AT細胞 / 正常ヒト細胞 / テロメラーゼ遺伝子導入不死化 / フォーカス形成 / 特異抗体 / DNA2重鎖切断 / リン酸化H2AX蛋白 / リン酸化ATM蛋白 / γH2AX / p53蛋白 / シグナル伝達系 / リン酸化 / 不死化ヒト細胞株 / 低線量率放射線 / 定量PCR / ヒストンH1ファミリー / 遺伝子発現変化 / マイクロアレイ / 放射線応答 / ATM蛋白 / 低線量、低線量率放射線 / ヒト細胞 / テロメラーゼ遺伝子 / Hot spot / Mutation / supF gene / Checkpoint / p53 gene / X線感受性 / 紫外線感受性 / チェクポイント / タンデムトランジション / ホットスポット / supF遺伝子 / チェックポイント / p53遺伝子 / D310 / Δ4977 / Dループ / 放射線感受性 / ミトコシドリア / 変異 / コモン欠失 / 変異ホットスポット / 放射線 / ミトコンドリアDNA / ヌクレオチド除去修復 / フェーズII酵素 / フェーズI酵素 / 生活習慣 / 遺伝子多型 / 口腔がん / 稀なアリル / 多型性 / アンドロジェン感受性 / AS3遺伝子 / がん抑制遺伝子 / 共通欠失領域 / 13番染色体 / マイクロサテライト配列 / 食道がん細胞 / アポトーシス / 熱応答 / 細胞応答 / ストレス / DNA損傷 / p53 / ゲノム不安定性 / ヘテロデュープレックス / ヒトがん細胞 / DNAミスマッチ塩基対修復 / 染色体マッピング / 微小核融合法 / 皮膚がん / ハイブリダイゼ-ション / ras遺伝子 … More Except Principal Investigator 骨肉腫 / メチル転移酵素 / ヘテロ接合性の消失 / PCNA / 癌遺伝子 / 放射線抵抗性癌 / がん抑制遺伝子 / 内因性因子 / 栄養 / 同時曝露 / 複合要因 / 健康影響 / 環境汚染物質 / Mutation / 突然変異 / 遺伝子発現 / hMSH3 / RT-PCR / linkage analysis / C-myc / 【O^6】-メチルグアニン / 細胞内情報伝達 / ゲノム不安定性 / 放射線応答 / 色素性乾皮症 / p53 / raf / 悪性黒色腫 / PLDR / ウイルムス腫瘍 / 網膜芽細胞腫 / 劣性癌遺伝子 / 予後因子 / Aging / Chromosome aberration / Cell transformation / Nucleotide sequence change / cAMP receptor gene / X-rays / DNA鎖切断の修復 / 損傷修復 / 潜在性致死 / エックス線の影響 / 潜在性致死損傷回復 / DNA塩基置換 / 加令 / 発癌 / 加齢 / 染色体異常 / トランスフオーメーション / 塩基配列の変化 / CAMPレセプター遺伝子 / エックス線 / Excision repair / Pyrimidine dimer / <O^6> -Methylguanine Methyltransferase / Gene cloning / DNA repair mechanisms / 電気穿孔法 / 除去修復 / ピリミジンダイマー / 遺伝子クローニング / DNA修復機構 / Defense mechanism / cDNA cloning / DnaJ homologs / Hsp40 / Stress response / Molecular chaperone / 生体防御 / cDNAクローニング / DnaJ相同体 / 分子シャペロン / ストレス応答 / Radiosensitivity / Genetic instability / Oxidative stress / Cell cycle regulation / Signal transduction / Gene expression / Radiation response / 放射線感受性遺伝子 / 適応応答 / 遺伝子的不安定性 / 放射線感受性 / 遺伝的不安定性 / 酸化ストレス / 細胞周期制御 / 情報伝達 / Gene Therapy / Drug Design / Cell Adhesion / Cell Cycle / Signal Transduction / Information Exchange / Cancer / International Scientific Research / 細胞増殖 / 癌化学療法 / 癌遺伝子治療 / ドラッグデザイン / 情報交換 / 化学発癌 / 癌治療 / 細胞接着 / ウイルス発癌 / 遺伝子治療 / 薬品設計 / 細胞周期 / シグナル伝達 / 細胞社会学 / 癌 / 海外派遣 / 国際学術 / p53-deficient / DNA polymerase alpha / (6-4) photoproduct / 8-hydroxyguanine / caffeine / XPE-BF / 8-ヒドロキシグアニン(oh^8Gua) / PCNAとXPACタンパク質との相互作用 / interstrand cross-links / 8-ヒドロキシングアニン(oh8Gua) / PCNAとXPAタンパク質との相互作用 / p53欠損細胞 / 8-ヒドロキシグアニン(oh8Gua) / p53欠損 / RCNA / DNAポリメラーゼα / (6-4)光産物 / 8-ハイドロオキシグアニン / カフェイン / aspiration cytology / liver function / partial liver transplantation / 肝再生 / PT-PCR / 穿刺吸引細胞診 / 移植肝機能評価 / 部分肝移植 / Transcriptional regulation / Growth control / Cancer cells / Tumor suppressor gene / Tumor promoter / Tumor virus / Oncogene / Information exchange / 研究集会 / 研究室訪問 / 北米 / 研究交流 / がん研究 / 転写調節 / 増殖制御 / がん細胞 / 発がんプロモーター / ウイルス発がん / がん遺伝子 / 研究情報交換 / p53 tumor suppressor gene / loss of heterozygosity / multiple exostosis / ヘテロ接合性消失 / 染色体分析 / 脱分化型軟骨肉腫 / p53癌抑制遺伝子 / 連鎖解析 / 二次性軟骨肉腫 / 多発性外骨腫 / N-methyl-N'-nitro-N-nitrosoguanidine / hot spot / Base substitution / DNA sequencing / E. coli crp gene / X-ray-induced mutations / 塩基置換突然変異 / トランジション突然変異 / DNAシーケンシング / MNNG誘発突然変異 / ニトロソグアニジン / ホットスポット / 塩基置換型突然変異 / DNAシ-ケンシング / 大腸菌crp遺伝子 / X線誘発突然変異 / 老化 / 癌化 / DNAメチル化 / 修復 / DNA損傷 / 紫外線 / 体細胞突然変異 / 網膜芽細胞遺伝子 / モノクローナル抗体 / Mer^-型がん組織 / O^6-メチルグアニン / ACNU / ヌードマウス / Mer^-細胞 / トランスフェクション / ada遺伝子 / O^6ーメチルグアニン / Me【r^-】 / DNAトランスフェクション / アルキル化剤 / DNA修復 / ヒト腫瘍細胞 / 遺伝子損傷性ストレス / 標的理論 / 放射線発がん / レドックス制御 / 放射線影響 / 発癌性突然変異 / UV損傷に対する特異抗体 / 修復遺伝子 / 修復酵素 / PLD / 色素性乾皮症A群の遺伝子診断 / in vitro修復検出系 / UV誘発突然変異 / UV損傷単クロ-ン抗体 / DNA依存性ATPase / DNA除去修復 / A群色素性乾皮症相神遺伝子 / がんの家族集積 / LiーFraumeni症候群 / 家族性大腸ポリポ-ジス / 遺伝性腫瘍 / SLDR / ras / ファイブロサルコ-マ / RB遺伝子 / 肺がん / 乳がん / 多内分泌腺腫瘍症 / 神経芽細胞腫 / p53遺伝子 / 網膜芽細胞腫遺伝子 Less

口腔がんの発生に関与する遺伝子多型と生活習慣の相互作用Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
放射線によるミトコンドリアDNAの変異誘発Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Aichi Cancer Center Research Institute
Molecular mechanisms of the response to low-dose radiation in hTERT-immortalized human cellsPrincipal Investigator
- Principal Investigator
  
  ISHIZAKI Kanji
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Aichi Cancer Center
食道がんの予後に関連する13番染色体上の遺伝子変異の同定Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Aichi Cancer Center Research Institute
DNAミスマッチ塩基対修復欠損と環境変異源高感受性Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Aichi Cancer Center Research Institute
Environmental stress responsive genes and defense mechanisms of living cells
- Principal Investigator
  
  OHTSUKA Kenzo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Aichi Cancer Center Research Institute
DNAミスマッチ塩基対修復欠損と環境変異源高感受性との関連Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Aichi Cancer Center Research Institute
放射線影響研究の新しい展開
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Kyoto University
DNA損傷やストレスに対する細胞応答へのP53遺伝子の関与Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Aichi Cancer Center Research Institute
DNAミスマッチ塩基対修復に欠損を示すヒト集団の検出Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Aichi Cancer Center Research Institute
Information Exchange on Cancer Research with North American
- Principal Investigator
  
  YAMAMOTO Tadashi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The University of Tokyo
Gene regulation of radiation response
- Principal Investigator
  
  SASAKI Masao
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  KYOTO UNIVERSITY
Involvement of tumor suppresser genes in DNA repairPrincipal Investigator
- Principal Investigator
  
  IHSIZAKI Kanji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Aichi Cancer Center
Regulatory mechanisum for maintainance of genetic information
- Principal Investigator
  
  UTSUMI Hiroshi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
放射線抵抗性癌の成因とその増感
- Principal Investigator
  
  内海博司
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
色素性乾皮症の修復欠損に関する遺伝子とタンパク質の異常
- Principal Investigator
  
  藤原美定
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
太陽紫外線によってヒト皮膚細胞に誘発された突然変異の解析Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
染色体移入法による色素性乾皮性C.F.群遺伝子の染色体マッピングPrincipal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
Evaluation of the function and the regeneration ability of the transplanted partial liver using a small amount of hepatocytes obtained by fine needle aspiration biopsy.
- Principal Investigator
  
  TANAKA Koichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Digestive surgery
- Research Institution
  KYOTO UNIVERSITY
がん抑制に関与する遺伝子群の研究
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
放射線抵抗性がんの成因とその増感
- Principal Investigator
  
  内海博司
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
色素性乾皮症の修復欠損に関わる遺伝子とタンパクの異常
- Principal Investigator
  
  藤原美定
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kobe University
太陽紫外線によってヒト皮膚細胞に誘発された突然変異の解析Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Information Exchange on Cancer Research with North American Countries.
- Principal Investigator
  
  YAMAGUCHI Nobuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Institute of Medical Science, University of Tokyo
がん抑制に関与する遺伝子群の研究
- Principal Investigator
  
  佐々木正夫
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
放射線抵抗性癌の成因とその増感
- Principal Investigator
  
  UTSUMI Hiroshi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
太陽紫外線によってヒト皮膚細胞に誘発された突然変異の解析Principal Investigator
- Principal Investigator
  
  石崎寛治
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
The identification of the genes involved in the development and progression of multiple osteo chondromas.
- Principal Investigator
  
  KOTOURA Yoshihiko
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyoto University
骨肉腫の予後因子としての劣性癌遺伝子の変化
- Principal Investigator
  
  山室隆夫
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Analysis of DNA Sequence Changes in Radiation-Induced Mutations.
- Principal Investigator
  
  IKENAGA Mituo
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
O^6メチルグアニン修復不能がん細胞の特性
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
骨肉腫の予後因子としての劣性癌遺伝子の変化
- Principal Investigator
  
  山室隆夫
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
DNA損傷の修復された後にみられるc-myc遺伝子のメチル化と活性の変化
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  放射線5生物学
- Research Institution
  Tohoku University
環境汚染物質の健康影響に関与する複合要因
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
環境汚染物質の健康影響に関与する複合要因
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
環境汚染物質の健康影響に関与する複合要因
- Principal Investigator
  
  井村伸正
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kitasato University
O^6-メチルグアニン修復不能がん細胞の特性
- Principal Investigator
  
  IKENAGA Mituo
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
O^6ーメチルグアニン修復不能がん細胞の特性
- Principal Investigator
  
  池永満生
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
Comparative analysis of DNA repair mechanisms in various species
- Principal Investigator
  
  IKENAGA Mituo
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  Radiation Biology Center, Kyoto University
Molecular mechanisms for X-ray induced mutagenesis, carcinogenesis and aging
- Principal Investigator
  
  IKENAGA Mituo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University

All 2005 2004 Other

All Journal Article

[Journal Article] Two haplotypes of 5' untranslated region in L-myc gene with different internal ribosome entry site activity.2005
- Author(s)
  Kumimoto, H., Yamane, Y., Ishizaki, K.
- Journal Title
  
  Int J Oncol. 26
  
  Pages: 287-293
- Data Source
  KAKENHI-PROJECT-16024224
[Journal Article] No Induction of p53Phosphorylation and Few Focus Formation of Phosphorylated H2AX suggest efficient Repair of DNA Damage During Chronic Low-dose-rate Irradiation in Human Cells2004
- Author(s)
  Kanji Ishizaki
- Journal Title
  
  Journal of Radiation research 45・4
  
  Pages: 521-525
- NAID
  110004041056
- Data Source
  KAKENHI-PROJECT-14380260
[Journal Article] No induction of p53 phosphorylation and few focus formation of γ H2AX suggest efficient repair of DNA damage by LDR irradiation.2004
- Author(s)
  Ishizaki, K. et al.
- Journal Title
  
  J.Radiation Res. 45
  
  Pages: 521-525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14380260
[Journal Article] Frequent somatic mutations of mitochondrial DNA in esophageal squamous cell carcinoma.2004
- Author(s)
  Kumimoto, H., Yamane, Y., Nishimoto, Y., Fukami, H., Shinoda, M., Hatooka, S.Ishizaki, K.
- Journal Title
  
  Int.J.Cancer 108
  
  Pages: 228-231
- Data Source
  KAKENHI-PROJECT-16651029
[Journal Article] 食道がんとミトコンドリアゲノムの変異
- Author(s)
  組本博司, 石崎寛治
- Journal Title
  
  細胞印刷中
- Data Source
  KAKENHI-PROJECT-16651029

1. SASAKI Masao (20013857)

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2. UTSUMI Hiroshi (20025646)

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ISHIZAKI Kanji 石崎 寛治

石崎 憲治 イシザキ ケンジ

Research Projects

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Co-Researchers

口腔がんの発生に関与する遺伝子多型と生活習慣の相互作用Principal Investigator

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放射線によるミトコンドリアDNAの変異誘発Principal Investigator

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Molecular mechanisms of the response to low-dose radiation in hTERT-immortalized human cellsPrincipal Investigator

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食道がんの予後に関連する13番染色体上の遺伝子変異の同定Principal Investigator

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DNAミスマッチ塩基対修復欠損と環境変異源高感受性Principal Investigator

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DNAミスマッチ塩基対修復欠損と環境変異源高感受性との関連Principal Investigator

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DNA損傷やストレスに対する細胞応答へのP53遺伝子の関与Principal Investigator

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DNAミスマッチ塩基対修復に欠損を示すヒト集団の検出Principal Investigator

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Involvement of tumor suppresser genes in DNA repairPrincipal Investigator

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ISHIZAKI Kanji 石崎寛治

石崎憲治イシザキケンジ