ONO Tetsuya 小野哲也

Researcher Number	00107509
Other IDs
Affiliation (based on the past Project Information) *help	2007 – 2011: Tohoku University, 大学院・医学系研究科, 教授 2006: 東北大学, 大学院医学系研究科, 教授 2001 – 2005: 東北大学, 大学院・医学系研究科, 教授 2004: Tohoku University, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 2001: 東北大学, 医学部・ゲノム生物学分野, 教授 … More
Review Section/Research Field	Principal Investigator 放射線5生物学 / Risk sciences of radiation/Chemicals / 環境影響評価(含放射線生物学) / 老化(加齢) / General medical chemistry / Dermatology / Radiation science Except Principal Investigator Radiation science / Cerebral neurosurgery / Radiation science … More
Keywords	Principal Investigator 放射線 / 突然変異 / トランスジェニックマウス / DNAメチル化 / 老化 / 環境変異原 / lacZ / 癌化 / マウス / 分化 … More Except Principal Investigator 放射線 / 突然変異 / ataxia telangiectasia / DNA-PK / DNA修復 / 5ーアザシチジン / 指趾奇形 / cーmyc / ATM / トランスジェニックマウス / transgenic mouse / lacZ gene / bleomycin / mitomycin / phosphatidylinositol 3-kinase / wortmannin / p38 / Rb / ノックアウトマウス / Mutation / AER / ラット / ATDC / 癌化 / SV40 / AT / アンチセンス / 毛細血管拡張性運動失調症 / Ku70 / Ku80 / genomic imprinting / glioma / IGF2 / H19 / human / cancer / 放射線適応応答 / クリプトマイクロコロニー / 放射線治療 / マウス / 被曝時年齢依存性 / 発がん / 被曝時年令依存性 / 【O^6】-メチルグアニン / メチル転移酵素 / ヒト腫瘍細胞 / アルキル化剤 / DNAトランスフェクション / Me【r^-】 / プロトン / α-線 / x-線 / 活性酵素 / supF遺伝子 / tonB遺伝子 / lacZ遺伝子 / LacZ遺伝子 / 水酸ラジカル / トランスバ-ジョン型変異 / 間接作用 / proton / alpha-ray / x-ray / active oxygen / supF gene / tonB gene / インジェノマウス / lacZ / 放射線影響 / 遺伝子突然変異 / プラスミドベクター / P-gal選択法 / Ingeno mouse / Radiation effect / gene mutation / RBE / plasmid vector / p-gal positive selection / 放射線感受性 / PI-3キナーゼ / scidマウス / ionizing radiation / radiation sensitivity / テロメア / 細胞老化 / エピジェネティックス / DNA複製 / 複製 / DNAポリメラーゼα / 温度感受性株 / Robertson融合 / エピジェネティック / 減数分裂 / 紡錘極体 / Taz1 / がん抑制機構 / MAPK / p53 / テロメラーゼ / Rap1 / TERT / 試験管内複製系 / telomere / cellular senescence / epigenetics / DNA replication / チミンDNAグリコシラーゼ(TDG) / 胎生致死 / カテコールアミン / Thymine DNA Glycosylase(TDG) / DNA repair / Knockout mouse / Embryonic lethality / Catecholamine / エックス線 / CAMPレセプター遺伝子 / 塩基配列の変化 / トランスフオーメーション / 染色体異常 / 加齢 / C-myc / 発癌 / 加令 / DNA塩基置換 / 潜在性致死損傷回復 / エックス線の影響 / 潜在性致死 / 損傷修復 / DNA鎖切断の修復 / X-rays / cAMP receptor gene / Nucleotide sequence change / Cell transformation / Chromosome aberration / Aging Less

Studies on age-dependency of radiation-induced mutation and its mechanism
- Principal Investigator
  
  UEHARA Yoshihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
放射線による腸死に対する治療法としての幹細胞移植の可能性の探索Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Molecular mechanisms for a suppressive effect of calorie restriction on cancer induction by radiationPrincipal Investigator
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
放射線適応応答を応用した新放射線治療法の開発
- Principal Investigator
  
  高井良尋
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
脳におけるDNA二重鎖切断の解析Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
Analysis of biological significance of elevated mutationPrincipal Investigator
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  Tohoku University
The Effect of Mismatch-Specific Thymine DNA Glycosylase (TDG) Deficiency on Spontaneous Mutation in Mice
- Principal Investigator
  
  UEHARA Yoshihiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
Characteristics of spontaneous mutations in mouse germ cellsPrincipal Investigator
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Institution
  Tohoku University
Chromosomal Instability Mediated by Telomere Insufficiency
- Principal Investigator
  
  ISHIKAWA Fuyuki
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
  Tokyo Institute of Technology
発現している遺伝子を標的とした新しい変異原検出用マウスの可能性Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
低線量放射線による適応応答は個体レベルでの突然変異誘発にも働くかPrincipal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
Effect of a phosphatidylinositol 3-kinase inhibitor wortmannin on radiation and bleomycin sensitivities.
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
少量の変異原にさらされた時の遺伝子への影響Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
アンチセンスATM遺伝子治療による放射線増感効果
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
皮膚における紫外線誘発突然変異Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Tohoku University
アンチセンスKup70/80DNAを用いた放射線遺伝子治療
- Principal Investigator
  
  細井義夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
ヒト神経膠腫の発癌機構へのloss of imprinting (LOI)の関与
- Principal Investigator
  
  上野眞二
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Tohoku University
少量の変異原に長期間さらされた時の遺伝子への影響Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
DNAメチルトランスフェラーゼ活性の老化への関与Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
ヒト腫瘍の放射線感受性因子としてのATDC遺伝子発現の関与
- Principal Investigator
  
  HOSOI Yoshio
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Radiation science
- Research Institution
  Tohoku University
Research and development of transgenic mouse for biological effect assesment of tritium
- Principal Investigator
  
  KOMATSU Kenshi
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Nuclear fusion studies
- Research Institution
  HIROSHIMA UNIVERSITY
Establishment of transgenic mice for detection of deletion type mutationsPrincipal Investigator
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  Tohoku University
個体の老化に伴う遺伝的変化とエピジェネティックな変化の比較Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  老化(加齢)
- Research Institution
  Tohoku University
Molecular mechanisms of proton and x-ray mutagenesis
- Principal Investigator
  
  YAMAMOTO Kazuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  TOHOKU UNIVERSITY
A search of methods to enhance the capacity to resist against radiation-induced acute injuries.Principal Investigator
- Principal Investigator
  
  ONO Tetsuya
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  放射線5生物学
- Research Institution
  TOHOKU UNIVERSITY
分化、老化、癌化の過程で変化するDNAメチル化の生物学的意義Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
指趾発生過程を指標にした催奇形性物質スクリ-ニング法の開発
- Principal Investigator
  
  栗下昭弘
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
cーmyc遺伝子のメチル化が分化、老化、癌化過程で変化する要因の解析Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tohoku University
指趾発生過程を指標にした催奇形性物質スクリ-ニング法の開発
- Principal Investigator
  
  KURISHITA Akihiro
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
DNA損傷の修復された後にみられるc-myc遺伝子のメチル化と活性の変化Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  放射線5生物学
- Research Institution
  Tohoku University
被爆後生き残った細胞に於ける遺伝子構造の変化Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
O^6-メチルグアニン修復不能がん細胞の特性
- Principal Investigator
  
  IKENAGA Mituo
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
放射線のひきおこす遺伝子活性の変化Principal Investigator
- Principal Investigator
  
  小野哲也
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University
Molecular mechanisms for X-ray induced mutagenesis, carcinogenesis and aging
- Principal Investigator
  
  IKENAGA Mituo
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  放射線5生物学
- Research Institution
  Kyoto University

All 2011 2010 2008 2007 2006 2004 2003

All Journal Article Presentation Book

[Book] 新老年学第3版2010
- Author(s)
  小野哲也, 上原芳彦, 小村潤一郎
- Publisher
  東京大学出版会
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article] Radiation dose-rate effect on mutation induction in spleen and liver of gpt delta mice2010
- Author(s)
  N. Okudaira, Y. Uehara, T. Ono, 他(16名中2番目, 16番目)
- Journal Title
  
  Radiation Research 173(3)
  
  Pages: 138-147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article]2010
- Author(s)
  小野哲也
- Journal Title
  
  新老年学第3版(東京大学出版会)
  
  Pages: 23-29
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article]2010
- Author(s)
  小野哲也
- Journal Title
  
  新老年学第3版(東京大学出版会)
  
  Pages: 23-29
- Data Source
  KAKENHI-PROJECT-21510053
[Journal Article]2010
- Author(s)
  小野哲也, 後藤佐多良, 上原芳彦
- Journal Title
  
  新老年学第3版(東京大学出版会)
  
  Pages: 23-29
- Data Source
  KAKENHI-PROJECT-21659282
[Journal Article] Germ cell tumors in the basal ganglia : problems of early diagnosis and treatment2008
- Author(s)
  Sonoda Y, Kumabe. T, Sugiyama S, et.al.
- Journal Title
  
  J Neurosurg Pediatrics 2
  
  Pages: 118-24
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19659301
[Journal Article] Absence of Ku70 gene obliterates X-ray-induced lacZ mutagenesis of small deletions in mouse tissues2008
- Author(s)
  Y. Uehara, H. Ikehata, T. Ono, 他(16名中1番目, 16番目)
- Journal Title
  
  Radiation Research 170(2)
  
  Pages: 216-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19201011
[Journal Article] Mutation spectrum in UVB-exposed skin epidermis of Xpa-knockout mice : frequent recovery of triplet mutations.2007
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Environmental and Molecular Mutagenesis 48
  
  Pages: 1-13
- Data Source
  KAKENHI-PROJECT-18651023
[Journal Article] Significance of CpG methylation for solar UV-induced mutagenesis and carcinogenesis in skin.2007
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Photochemistry and Photobiology 83
  
  Pages: 196-204
- Data Source
  KAKENHI-PROJECT-18651023
[Journal Article] The maintenance of genome integrity is tissue-specific.2006
- Author(s)
  T.Ono
- Journal Title
  
  Genes and Environment (in press)
- NAID
  110004740318
- Data Source
  KAKENHI-PROJECT-15310031
[Journal Article] The maintenance of genome integrity is tissue-specific.2006
- Author(s)
  T.Ono
- Journal Title
  
  Genes and Environment 28
  
  Pages: 16-22
- NAID
  110004740318
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310031
[Journal Article] Spontaneous mutations in digestive tract of old mice show tissue-specific patterns of genomic instability.2004
- Author(s)
  Tetsuya Ono
- Journal Title
  
  Cancer Research 64・19
  
  Pages: 6919-6923
- Data Source
  KAKENHI-PROJECT-15310031
[Journal Article] Mutation spectrum in sunlight-exposed mouse skin epidermis : small but appreciable contribution of oxidative stress-mediated mutagenesis.2004
- Author(s)
  Hironobu Ikehata
- Journal Title
  
  Mutation Research 556・1-2
  
  Pages: 11-24
- Data Source
  KAKENHI-PROJECT-15310031
[Journal Article] Spontaneous mutations in digestive tract of old mice show tissue-specific patterns of genomic instability.2004
- Author(s)
  T.Ono
- Journal Title
  
  Cancer Research 64
  
  Pages: 6919-6923
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310031
[Journal Article] Molecular nature of mutations induced by irradiation with repeated low doses of X-rays in spleen, liver, brains and testis of lacZ-transgenic mice.2003
- Author(s)
  T.Ono
- Journal Title
  
  International Journal of Radiation Biology 79
  
  Pages: 635-641
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15310031
[Presentation] 放射線誘発突然変異のエイジ依存性2011
- Author(s)
  小野哲也
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸商工会議所会館(神戸市)
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21510053
[Presentation] 放射線誘発突然変異のエイジ依存性2011
- Author(s)
  小野哲也、上原芳彦、池畑広伸、小村潤一郎
- Organizer
  日本放射線影響学会第54回大会
- Place of Presentation
  神戸市
- Year and Date
  2011-11-18
- Data Source
  KAKENHI-PROJECT-21510053
[Presentation] NHEJ plays a major role in radiation-mutagenesis in mouse tissues.2008
- Author(s)
  Tetsuya Ono
- Organizer
  The Fifth International Symposium of 21st Century COE Program Hiroshima University
- Place of Presentation
  広島大学
- Data Source
  KAKENHI-PROJECT-18651023

1. IKEHATA Hironobu (90250737)

# of Collaborated Projects: 13 results

# of Collaborated Products: 1 results
2. HOSOI Yoshio (50238747)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. UEHARA Yoshihiko (30223499)

# of Collaborated Projects: 5 results

# of Collaborated Products: 4 results
4. KURISHITA Akihiro (60201472)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. ISHIZAKI Kanji (70111987)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. 小村潤一郎 (10215410)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. IKENAGA Mituo (70025378)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. YAMAMOTO Kazuo (20093536)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NORIMURA Toshiyuki (20039530)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SHIMADA Yoshiya (10201550)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOMATSU Kenshi (80124577)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ENDO Satoru (90243609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. MATSUURA Shinya (90274133)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SOFUNI Toshio (20132889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YAMADA Shyogo (60158194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. ISHIKAWA Fuyuki (30184493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. NAKAMURA Nori (00010116)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. OKADA Shigefumi (70010048)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. UTSUMI Hiroshi (20025646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. SASAKI Masao (20013857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 上野眞二 (60271897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 吉本高志 (50091765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 高井良尋 (50107653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 仲田栄子 (60375201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 田内広 (70216597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. INOUE Hiroaki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

ONO Tetsuya 小野 哲也

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

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Research Institution

放射線による腸死に対する治療法としての幹細胞移植の可能性の探索Principal Investigator

Principal Investigator

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Molecular mechanisms for a suppressive effect of calorie restriction on cancer induction by radiationPrincipal Investigator

Principal Investigator

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Principal Investigator

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脳におけるDNA二重鎖切断の解析Principal Investigator

Principal Investigator

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Research Institution

Analysis of biological significance of elevated mutationPrincipal Investigator

Principal Investigator

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Principal Investigator

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Research Category

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Characteristics of spontaneous mutations in mouse germ cellsPrincipal Investigator

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Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

発現している遺伝子を標的とした新しい変異原検出用マウスの可能性Principal Investigator

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低線量放射線による適応応答は個体レベルでの突然変異誘発にも働くかPrincipal Investigator

Principal Investigator

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Principal Investigator

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少量の変異原にさらされた時の遺伝子への影響Principal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Research Institution

皮膚における紫外線誘発突然変異Principal Investigator

Principal Investigator

ONO Tetsuya 小野哲也