HASHIMOTO Yuichi 橋本祐一

… Alternative Names

Researcher Number	90164798
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2018 – 2019: 東京大学, 定量生命科学研究所, 教授 1997 – 2017: THE UNIVERSITY OF TOKYO,Insititute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授 1993 – 1996: 東京大学, 分子細胞生物学研究所, 助教授 1995: 東京大学, 分生研, 助教授 1990 – 1992: 東京大学, 応用微生物研究所, 助教授 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / 医薬分子機能学 / Biological Sciences / Living organism molecular science Except Principal Investigator 医薬分子機能学 / Chemical pharmacy / Drug development chemistry
Keywords	Principal Investigator サリドマイド / 構造展開 / レチノイド / フタルイミド / 構造活性相関 / 阻害剤 / 核内受容体 / アンタゴニスト / 腫瘍壊死因子 / 酵素阻害剤 … More Except Principal Investigator レチノイド / レチノイン酸 / チューブリン / 有糸分裂阻害剤 / 分化誘導 / ウスチロキシン / キュラシンA / レチノイドアンタゴニスト / ビタミンA / アンタゴニスト / 急性前骨髄球性白血病 / レセプター / 分化 / オカダ酸 / オカダ酸クラス発がんプロモ-タ- / ミクロチスチン / チュ-ブリン / レチノイドレセプタ- / 形態形成 / 転移 / 血管新生 / 有糸分裂 / Phomopsin A / Rhizoxin / Maytansine部位 / 分子認識機構 / 血管新生阻害 / 微小管機能 / 分子認識 / 複合体構造 / レチノイン酸レセプター / PML / 分化誘導療法 / Am-80 / 細胞内レチノイン酸結合蛋白 / 癌 / リウマチ / アレナスタチンA / サリドマイド / 細胞分化 / ビタミンA酸 / 白血病 / 分子設計 / HL60 / retinoid / retinoic acid / leukemia / differentiation / 蛋白質脱リン酸化酵素2A / プロスタグランジンE_2 / protein kinase C / CNーTPBP / 精密構造認識 / VLB / MAY部位 / リゾキシン / メイタンシン / 核内レセプタ- / アンチセンスDNA / 三重鎖 / (dA)_6 / レ-デオキシアデノシン / Lーアラビノ-ス / 分子進化 / レチイン酸 / プロティンフォスファタ-ゼ / アラキドン酸 / JE遺伝子 / TRE / プロテインキナ-ゼC / 制がん剤 / 転移抑制 / 鶏卵法検定 / チロキシンレセプター / Dolastatin 10 / Ustiloxin / 分子誘導療法 / ポリプレン酸 / ブファリン / ユビキチン・プロテアゾーム / トランスジェニック・マウス / 核内レセプター / 乾癖 / 微小管 / RARA / 亜砒酸 / PET / 高速メチル化 / 蛍光プローブ / 人工核酸 / キナーゼ / 阻害剤 / 神経因性疼痛 / シグナル解析 / 3成分連結PG合成法 / non-RI光親和性標識法 / ABCトランスポーター / Socius / 神経性疼痛 / プラナーポジトロンイメージング / MicroPET / 光親和性標識法 / キナーゼ阻害剤 / 34mCl / プロスグランジン / RXRアンタゴニスト / 可視化プローブ / 4'-チオリボヌクレオシド / ダントロレン誘導体 / Cu-ATSM / リピドA / 15R-TIC / リアノジン受容体 / PGE_2 / アロディニア / DNAチップ / 生物活性物質 / 構造展開 / 構造活性相関 / 代謝物 / LiverX受容体(LXR) / α-グルコシダーゼ / 細胞増殖阻害 / 腫瘍壊死因子(TNF)-α / チューブリン重合阻害 / 核内受容体 / シクロオキシゲナーゼ / 活性評価 / 癌治療薬 / テレフタル酸アリリド / カルコンカルボン酸・分化 / リセプタータンパク / 酸異性化 / 核中レセプター / X線結晶解析 / がん / レチノイドレセプター / 核レセプタ- / 癌治療 / シリコン / vitamin A / retinoid antagonist / cancer / retinoid receptor / 核レセプター / ステロイド / チロイド / チロイドリセプター / 腫瘍悪性化 / チロキシン / フオルボール / ジベンゾジアゼピン / ベンゾラクタム / tyroids / myeloma / antagonist synergist / 作用機作 / antimitotic agent / tubulin / action mechanism / molecular design / ustiloxins / curacin A / arenastatin A Less

Structural and functional development studies of ligands for disease progression factorsPrincipal Investigator
- Principal Investigator
  
  Hashimoto Yuichi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Development of silicon-containing units as expanded bioisostersPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Polypharmacology based on dynamism of the target proteinPrincipal Investigator
- Principal Investigator
  
  Hashimoto Yuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Chemical biology of trafficking regulation of membrane cholesterol transporter proteinPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Chemical control of protein dramatypePrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target ProteinsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
Biological response modification based on multi-template and dramatype approaches.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Thalidomide as a cell differentiation regulator
- Principal Investigator
  
  NOGUCHI Tomomi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Development of anti-tumor agents based on biological response modification.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
サリドマイドの抗糖尿病薬への展開Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
がん増悪因子を阻害する医薬リードの創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Design and development of biological response modifiersPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
サリドマイドの構造展開による、がん増悪因子を阻害する医薬リードの創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
生物新機能と創薬をめざす生体内分子科学
- Principal Investigator
  
  鈴木正昭
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Gifu University
サリドマイドの構造展開による,がん増悪因子を阻害する医薬リードの創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ホルモンとしてのサリドマイド・・・細胞検定を指標にした構造展開Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
生物応答調節剤による発がん過程の修飾と予防Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
生物応答調節分子の設計と活性発現機構Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Structural development of bio-active compounds affecting nuclear receptor functionPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
生物応答調節分子の設計と活性発現機構Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
微小管機能を制御する超分子形成とリガンド機能の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
エンドペプチダーゼ組み合わせ法によるレセプターラベル部位の決定Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
レチノイドの化学・生物学・医学研究
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulatorsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
発癌プロモーターとレチノイドのクロストークPrincipal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
フタルイミド系新規TNF(腫瘍壊死因子)産生抑制剤の創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Preparation of Functional Polylipid BiofactorsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  THE UNIVERSITY OF TOKYO
デキストラン法による脂溶性分子の水溶液中での挙動解析Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Regulatory compound of nuclear receptor functions.
- Principal Investigator
  
  SHUDO Koichi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  University of Tokyo, Faculty of pharm.Sciences
非細胞傷害性抗がん化合物の合成と作用解析
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
発がんプロモーターの校内レセプターPrincipal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
有糸分裂阻害剤-チューブリン間の精密構造認識の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
アンチセンス/エナンチオDNAPrincipal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
発がんプロモ-タ-の核内レセプタ-Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
核内レセプタ-応答遺伝子の認識分子
- Principal Investigator
  
  SHUDO Koichi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
臨床応用を目指すレチノイドの研究
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Molecular design and synthesis of new retinoids
- Principal Investigator
  
  SHUDO Koichi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Univ. of Tokyo
発がんプロモ-ションの機構とその阻害
- Principal Investigator
  
  藤木博太
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
発がんプロモ-ションの機構とその阻害
- Principal Investigator
  
  藤木博太
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
新しい作用機作をもつ抗がん剤の合成と特性
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ビタミンA酸および関連化合物による分化誘導とその作用機作
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新しい作用機作をもつ抗がん剤の合成と特性
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
化学発癌物質によるオンコジンの化学修飾と活性化Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

[Book] 生体有機化学2012
- Author(s)
  橋本祐一・村田道雄　編著
- Total Pages
  215
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-22249006
[Book] Interaction of biological response modifier with proteins. In "Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications"(ed. By Osada H)2009
- Author(s)
  Hashimoto Y
- Publisher
  (John Wiley & Sons, New Jersey)
- Data Source
  KAKENHI-PROJECT-19390028
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆)
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆), 半田宏編
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Data Source
  KAKENHI-PROJECT-15659025
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆), 半田宏編
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Data Source
  KAKENHI-PROJECT-14103018
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆), 半田宏編
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Lucifer's-based HMG-CoA reductase degradation assay for activity and selectivity profiling of oxy(lano) sterols2020
- Author(s)
  Sagimori Ikuya、Yoshioka Hiromasa、Hashimoto Yuichi、Ohgane Kenji
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Pages: 115298-115298
- DOI
  10.1016/j.bmc.2019.115298
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
[Journal Article] Phosphine boranes as less hydrophobic building blocks than alkanes and silanes: Structure-property relationship and estrogen-receptor-modulating potency of 4-phosphinophenol derivatives2020
- Author(s)
  Saito Hiroki、Matsumoto Yuichiro、Hashimoto Yuichi、Fujii Shinya
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Pages: 115310-115310
- DOI
  10.1016/j.bmc.2020.115310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K22486, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997
[Journal Article] Application of protein knockdown strategy targeting β-sheet structure to multiple disease-associated polyglutamine proteins2020
- Author(s)
  Yamashita Hiroko、Tomoshige Shusuke、Nomura Sayaka、Ohgane Kenji、Hashimoto Yuichi、Ishikawa Minoru
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 28 Pages: 115175-115175
- DOI
  10.1016/j.bmc.2019.115175
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16326, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18H02551, KAKENHI-PROJECT-17K15487
[Journal Article] Structure-activity relationship study of estrogen receptor down-regulators with a diphenylmethane skeleton2019
- Author(s)
  Nanjyo Shun、Ohgane Kenji、Yoshioka Hiromasa、Makishima Makoto、Hashimoto Yuichi、Noguchi- Yachide Tomomi
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 27 Pages: 1952-1961
- DOI
  10.1016/j.bmc.2019.03.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K06570, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17K15487
[Journal Article] Multiplexing fluorogenic esterase-based viability assay with luciferase assays2019
- Author(s)
  Ohgane Kenji、Yoshioka Hiromasa、Hashimoto Yuichi
- Journal Title
  
  MethodsX
  
  Volume: 6 Pages: 2013-2020
- DOI
  10.1016/j.mex.2019.09.008
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-18J14851, KAKENHI-PROJECT-17K15487
[Journal Article] Design, synthesis and biological evaluateon of novel nonsteroidal progesterone receptor antagonists based on phenyl-1,3,5-triazine scaffold.2019
- Author(s)
  Kaitoh Kazuma, Nakatsu Aki, Mori Shuji, Kagechika Hiroyuki, Hashimoto Yuichi, Fujii Shinya
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 67 Pages: 566-575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996
[Journal Article] Novel nonsteroidal progesterone receptor (PR) antagonists with a phenanthridinone skeleton.2018
- Author(s)
  Yuko Nishiyama, Shuichi Mori, Madoka Nakagomi, Makoto Makishima, Shinya Fujii, Hiroyuki Kagechika, Yuichi Hashimoto, and Minoru Ishikawa
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 9 Pages: 641-645
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996
[Journal Article] Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative2018
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 28 Pages: 707-710
- DOI
  10.1016/j.bmcl.2018.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Development of novel silanol-based human pregnane X receptor (PXR) agonists with improved receptor selectivity2018
- Author(s)
  Toyama H, Shirakawa H, Komai M, Hashimoto Y, Fujii S.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 26 Pages: 4493-4501
- DOI
  10.1016/j.bmc.2018.07.038
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03814, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15137
[Journal Article] Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility2018
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 28 Pages: 796-801
- DOI
  10.1016/j.bmcl.2017.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997
[Journal Article] Development of nonsteroidal glucocorticoid receptor modulators based on N -benzyl- N -(4-phenoxyphenyl)benzenesulfonamide scaffold2017
- Author(s)
  Yoshioka Hiromasa、Yamada Ayumi、Nishiyama Yuko、Kagechika Hiroyuki、Hashimoto Yuichi、Fujii Shinya
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25 Pages: 3461-3470
- DOI
  10.1016/j.bmc.2017.04.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15138
[Journal Article] Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein2017
- Author(s)
  Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
- Journal Title
  
  Bioorganig and Medicinal Chemistry Letters
  
  Volume: 27 Pages: 2781-2787
- DOI
  10.1016/j.bmcl.2017.04.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015
[Journal Article] Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression2017
- Author(s)
  Yosuke Toyota, Sayaka Nomura, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganig and Medicinal Chemistry Letters
  
  Volume: 27 Pages: 2776-2780
- DOI
  10.1016/j.bmcl.2017.04.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Synthesis and evaluation of novel dual BRD4/HDAC inhibitors2017
- Author(s)
  Amemiya Seika、Yamaguchi Takao、Hashimoto Yuichi、Noguchi-Yachide Tomomi
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 25 Pages: 3131-3134
- DOI
  10.1016/j.bmc.2017.04.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists2017
- Author(s)
  Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 27 Pages: 3131-3134
- DOI
  10.1016/j.bmcl.2017.05.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Progress in the medicinal chemistry of silicon: C/Si exchange and beyond2017
- Author(s)
  Fujii Shinya、Hashimoto Yuichi
- Journal Title
  
  Future Med. Chem.
  
  Volume: 9 Pages: 485-505
- DOI
  10.4155/fmc-2016-0193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15138
[Journal Article] Structure-activity relationship study of N6-benzoyladenine-type BRD4 inhibitors and their effects on cell differentiation and TNF-α production.2016
- Author(s)
  Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Nogichi-Yachide
- Journal Title
  
  Chemal and Pharmaceutical Bulletin
  
  Volume: 64 Pages: 1378-1383
- NAID
  130005261607
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293025
[Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.2016
- Author(s)
  Hirozumi Toyama, Shoko Sato, Hitoshi Shirakawa, Michio Komai, Yuichi Hashimoto, Shinya Fujii
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 26 Pages: 1817-1820
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15137
[Journal Article] Development of tetrachlorophthalimides as liver X receptor β (LXRβ)－selective agonists.2016
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  ChemMedChem.
  
  Volume: 11 Pages: 2347-2360
- DOI
  10.1002/cmdc.201600305
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamices as novel acetyl-CoA carboxylase 2 (AAC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.2016
- Author(s)
  Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 24 Pages: 5258-5269
- DOI
  10.1016/j.bmc.2016.08.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-16K17930
[Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.2016
- Author(s)
  Toyama H, Sato S, Shirakawa H, Komai M, Hashimoto Y, Fujii, S.
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume: 26 Pages: 1817-1820
- DOI
  10.1016/j.bmcl.2016.02.031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26292063, KAKENHI-PROJECT-26293025
[Journal Article] Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand.2016
- Author(s)
  Shusuke Tomoshige, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume: 24 Pages: 3144-3148
- DOI
  10.1016/j.bmc.2016.05.035
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-16K15137
[Journal Article] Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors2015
- Author(s)
  Noguchi-Yachide, T., Sakai, T., Hashimoto, Y., Yamaguchi, Y.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 23 Pages: 953-959
- DOI
  10.1016/j.bmc.2015.01.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-26810091, KAKENHI-PROJECT-15K08015
[Journal Article] Design and synthesis of novel ROR inverse agonists with a dibenzosilole scaffold as a hydrophobic core structure2015
- Author(s)
  Toyama, H.; Nakamura, M.; Hashimoto, Y.; Fujii, S.*
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Pages: 2982-2988
- DOI
  10.1016/j.bmc.2015.05.004
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-26293025
[Journal Article] Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules2015
- Author(s)
  Shusuke Tomoshige, Mikihiko Naito, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume: 13 Pages: 9746-9750
- DOI
  10.1039/c5ob01395j
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists2015
- Author(s)
  Daisuke Kajita, Masaharu Nakamura, Yotaro Matsumoto, Minoru Ishikawa, Yuichi Hashimoto and Shinya Fujii
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 25 Pages: 3350-3354
- DOI
  10.1016/j.bmcl.2015.05.045
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15J12421, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton2015
- Author(s)
  Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 23 Pages: 328-339
- DOI
  10.1016/j.bmc.2014.11.027
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-24590136, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators2015
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Atsushi Aoyama, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 6 Pages: 902-907
- DOI
  10.1021/acsmedchemlett.5b00170
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand2014
- Author(s)
  Y.Nishiyama, M.Nakamura, T.Misawa, M.Nakagomi, M.Makishima, M.Ishikawa, Y.Hashimoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Pages: 2799-2808
- DOI
  10.1016/j.bmc.2014.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670053
[Journal Article] Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout2014
- Author(s)
  Karaki, F., Ohgane, K., Fukuda, H., Nakamura, M., Dodo, K., Hashimoto, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 22 Pages: 3587-3609
- DOI
  10.1016/j.bmc.2014.05.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein2014
- Author(s)
  Ohgane, K., Karaki, F., Noguchi-Yachide, T., Dodo, K. Hashimoto, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 24 Pages: 3480-3485
- DOI
  10.1016/j.bmcl.2014.05.064
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist.2013
- Author(s)
  K. Maruyama, M. Nakamura, S. Tomoshige, K.Sugita, M.Makishima, Yuichi Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 23 Pages: 4031-4036
- DOI
  10.1016/j.bmcl.2013.05.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24590136, KAKENHI-PROJECT-25670053
[Journal Article] タンパク質の折りたたみの異常を直すファーマコロジカルシャペロン～ニーマンピック病C 型治療薬を目指した試み～2013
- Author(s)
  大金賢司、唐木文霞、闐闐孝介、橋本祐一
- Journal Title
  
  現代化学
  
  Volume: No.512, 11月号 Pages: 48-54
- URL
  http://www.tkd-pbl.com/news/nc243.html
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Structure-activity relationship studies of Nieman-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect2013
- Author(s)
  Karaki, F. ; Ohgane, K. ; Dodo, K. ; Hashimoto, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 21 Pages: 5297-5309
- DOI
  10.1016/j.bmc.2013.06.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670052
[Journal Article] Discovery of oxysterolderived pharmacological chaperones for NPC-1 : implication for the existence of second sterol-binding site2013
- Author(s)
  大金賢司, 唐木文霞, 〓〓孝介, 橋本祐一
- Journal Title
  
  Chemistry & Biology
  
  Volume: 20 Pages: 391-402
- DOI
  10.1016/j.chembiol.2013.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J10583, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670052
[Journal Article] フォールディング異常症に対する治療薬創製の可能性2012
- Author(s)
  橋本祐一
- Journal Title
  
  MEDCHEM NEWS
  
  Volume: 22 Pages: 25-28
- NAID
  130007895543
- URL
  http://medchem.pod.ne.jp/index.php?option=com_content&view=category&id=36&Itemid=56&lang=ja
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Design, synthesis, and biological evaluation of novel trans repression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6 H-dibenz[b,e]azepin-6-one skeleton2012
- Author(s)
  Atsushi Aoyama
- Journal Title
  
  J. Med. Chem.
  
  Volume: 55 Pages: 7360-7377
- DOI
  10.1021/jm3002394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006
[Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist.2012
- Author(s)
  Y. Itoh, M. Ishikawa, R.Kitaguchi, K.Okuhira, M.Naito, Y.Hashimoto
- Journal Title
  
  Bioorg Med Chem Lett.
  
  Volume: 22 Pages: 4453-4457
- DOI
  10.1016/j.bmcl.2012.04.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048, KAKENHI-PROJECT-23790125
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylatlon induced by hybrid molecules that crosslink cIAP1 and the target protein2012
- Author(s)
  K. Okuhira, N. Ohoka, K. Sai, T. Nishimaki-Mogami, Y. Itoh, M. Ishikawa, Y. Hashimoto, M. Naito
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 1147-1152
- DOI
  10.1016/j.febslet.2011.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
[Journal Article] Development of target proteinselective degradation inducer for protein knockdown2011
- Author(s)
  Y. Itoh, M. Ishikawa, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19 Pages: 3229-3241
- DOI
  10.1016/j.bmc.2011.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23659048
[Journal Article] フォールディング・トラフィッキング異常の修正作用を有するリガンドの創製～網膜色素変性症への応用を目指した、変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～2011
- Author(s)
  大金賢司,闐闐孝介,橋本祐一
- Journal Title
  
  薬学雑誌
  
  Volume: 131 Pages: 325-334
- NAID
  130000678893
- URL
  https://www.jstage.jst.go.jp/browse/yakushi/131/3/_contents/-char/ja/
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenetylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists2011
- Author(s)
  K.Motoshima, K.Sugita, Y.Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 21 Pages: 3041-3045
- DOI
  10.1016/j.bmcl.2011.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Fused heterocyclic amido compounds as anti-hepatitis C virus agents2011
- Author(s)
  Hiroshi Aoyama, Masahiko Nakamura
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 2675-2687
- DOI
  10.1016/j.bmc.2011.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J09835, KAKENHI-PROJECT-22249006
[Journal Article] Further application of the multitemplate approach for creation of biological response modifiers : discovery of a new class of multifunctional anti-diabetic agents2011
- Author(s)
  K.Motoshima, T.Noguchi-Yachide, M.Ishikawa, Y.Hashimoto, K.Sugita
- Journal Title
  
  Heterocycles
  
  Volume: 82 Pages: 1083-1101
- DOI
  10.3987/rev-10-sr(e)7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Design, Synthesis and Biological Evaluation of Nuclear Receptor-degradation Inducers2011
- Author(s)
  伊藤幸裕
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 19 Pages: 6768-6778
- DOI
  10.1016/j.bmc.2011.09.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09667, KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23790125
[Journal Article] Estrogen receptor α/β ligands derived from thalidomide2011
- Author(s)
  T.Noguchi-Yachide, K.Sugita, Y.Hashimoto
- Journal Title
  
  Heterocycles
  
  Volume: 83 Pages: 2137-2147
- DOI
  10.3987/com-11-12287
- NAID
  40018958922
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Peroxizome proliferator-activated receptor agonists with phenethylphenylpht halimide skeleton derived from thalidomide-related liver X receptor antagonists : relationship between absolute configuration and subtype selectivity2011
- Author(s)
  K.Motoshima, M.Ishikawa, Y.Hashimoto, K.Sugita
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 19 Pages: 3156-3172
- DOI
  10.1016/j.bmc.2011.03.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecules : design andsynthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins2010
- Author(s)
  Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
- Journal Title
  
  J. Amer. Chem. Soc
  
  Volume: 132 Pages: 5820-5826
- DOI
  10.1021/ja100691p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092
[Journal Article] Retinobenzaldehydes as propertrafficking inducers of foldingdefective P23H rhodopsin mutant responsible for Retinitis Pigmentosa2010
- Author(s)
  K.Ohgane, K.Dodo, Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume: 18 Pages: 7022-7028
- DOI
  10.1016/j.bmc.2010.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Nitrogen-containing fused-heteroaromatic compounds as a anti-bovine diarrhea virus (BVDV) agents.2010
- Author(s)
  Aoyama H, Baba M, Hashimoto Y
- Journal Title
  
  Curr. Bioactive Comp. 6(2)
  
  Pages: 118-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.2010
- Author(s)
  Mita Y, Dodo K, Noguchi-Yachide T, Miyachi H, Makishima M, Hashimoto Y, Ishikawa M
- Journal Title
  
  Bioorg. Med. Chem. Lett. 20(5)
  
  Pages: 1712-1717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Novel selective anti-androgens with a diphenylpentane skeleton2010
- Author(s)
  K.Maruyama, T.Noguchi-Yachide, K.Sugita, Y.Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 20 Pages: 6661-6666
- DOI
  10.1016/j.bmcl.2010.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecule: design and sythesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.2010
- Author(s)
  Itoh Y, Ishikawa M, Naito M, Hashimoto Y
- Journal Title
  
  J. Amer. Chem. Soc. 132(16)
  
  Pages: 5820-5826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Structural development studies of anti-hepatitis virus C virus agents2010
- Author(s)
  M.Nakamura, A.Aoyama, M.T.M.Salim, M.Okamoto, M.Baba, M.Baba, H.Miyachi, Y.Hashimoto, H.Aoyama
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume: 18 Pages: 2402-2411
- DOI
  10.1016/j.bmc.2010.02.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epi-gallocatechin gallate.2009
- Author(s)
  Kosuke Dodo, Taro Minato, Yuichi Hashimoto
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 57
  
  Pages: 190-194
- NAID
  110007042048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Discovery of tetramethyltetrahydronaphthalene analogs as adult T-cell leukemia cells-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis.2009
- Author(s)
  Nakamura M, Hamasaki T, Tokitou M, Baba M, Hashimoto Y, Aoyama H
- Journal Title
  
  Bioorg. Med. Chem. 17(13)
  
  Pages: 4740-4746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate2009
- Author(s)
  Dodo, K., Minato, T., Hashimoto, Y.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin 57(2)
  
  Pages: 190-194
- NAID
  110007042048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] マルチテンプレート手法によるサリドマイドの構造展開と活性拡張.2009
- Author(s)
  橋本祐一
- Journal Title
  
  和光純薬時報 77(1)
  
  Pages: 2-5
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.2009
- Author(s)
  Hosoda S, Matsuda D, Tomoda H, Hashimoto Y
- Journal Title
  
  Mini-Rev. Med. Chem. 9(5)
  
  Pages: 572-580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epi-gallocatechin gallate2009
- Author(s)
  Kosuke Dodo, Taro Minato, Yuichi Hashimoto
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 57
  
  Pages: 190-194
- NAID
  110007042048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Enhancement of chemically-induced HL-60 cell differentiation by 3, 3'-diindolulmethane derivatives.2009
- Author(s)
  Noguchi-Yachide T, Tetsuhashi M, Aoyama H, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 57(5)
  
  Pages: 536-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] New tubulin-polymerization inhibitor derived from thalidomide: implication for anti-myeloma therapy.2008
- Author(s)
  Kizaki M, Hashimoto Y
- Journal Title
  
  Curr. Med. Chem. 15(8)
  
  Pages: 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] New tubulin-polymerization inhibitor derived from thalidomide:Implications for anti-myeloma therapy.2008
- Author(s)
  Masahiro Kizaki and Yuichi Hashimoto
- Journal Title
  
  Curr. Med. Chem. 15(8)
  
  Pages: 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] 4-(Anilino)pyrrole-2-carboxiamides: novel non-steroidal/non-anilide type androgen antagonisits effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.2008
- Author(s)
  Wakabayashi K, Imai K, Miyachi H, Hashimoto Y, Tanatani A
- Journal Title
  
  Bioorg. Med. Chem. 16(14)
  
  Pages: 7046-7054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epigallocatechin gallate.2008
- Author(s)
  Kosuke Dodo, Taro Minato and Yuichi Hashimoto
- Journal Title
  
  Chem. Pharm. Bull. 57(2)
  
  Pages: 190-194
- NAID
  110007042048
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008
- Author(s)
  Hashimoto Y
- Journal Title
  
  Arch. Pharm. Life Sci. 341(9)
  
  Pages: 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Anriproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.2008
- Author(s)
  Dodo K, Minato T, Noguchi-Yachide T, Suganuma M, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 16(17)
  
  Pages: 7975-7982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] New tubulin polymerization inhibitor derived from thalidomide : Implications for anti-myeloma therapy2008
- Author(s)
  Kizaki, M. and Hashimoto, Y.
- Journal Title
  
  Current Medicianl Chemistry 15(8)
  
  Pages: 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis.2008
- Author(s)
  Misawa T, Aoyama H, Furuyama T, Dodo K, Sagawa M, Miyachi H, Kizaki M, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 56(10)
  
  Pages: 1490-1495
- NAID
  110006936309
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Co-existence of alpha-glucosidase-inhibitory activity and liver X receptor-regulatory activities and their separation by structural development.2008
- Author(s)
  Dodo K, Aoyama H, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 16(8)
  
  Pages: 4272-4285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008
- Author(s)
  Yuichi Hashimoto
- Journal Title
  
  Arch. Pharm. Life Sci. 341(9)
  
  Pages: 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.2008
- Author(s)
  Sato S, Tetsuhashi M, Sekine K, Miyachi H, Naito M, Hashimoto Y, Aoyama H
- Journal Title
  
  Bioorg. Med. Chem. 16(8)
  
  Pages: 4685-4698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008
- Author(s)
  Hashimoto Y
- Journal Title
  
  Arch. Pharm. Life Sci 341(9)
  
  Pages: 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds2008
- Author(s)
  Hashimoto, Y.
- Journal Title
  
  Archives der Pharmazie, Life Science 341(9)
  
  Pages: 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structural development studies of nuclear receptor ligands.2007
- Author(s)
  Hosoda S, Hashimoto Y
- Journal Title
  
  Pure Appl. Chem. 79(4)
  
  Pages: 615-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Development of tubulin-polymerization inhibitors based on thalidomide skeleton.2007
- Author(s)
  Aoyama H, Noguchi T, Misawa T, Nakamura T, Miyachi H, Hashimoto Y, Kobayashi H
- Journal Title
  
  Chem. Pharm. Bull. 55(6)
  
  Pages: 844-949
- NAID
  110006278705
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] 3, 3-Diphenylpentane skeleton as a steroid substitute: novel inhibitors for human 5α-reductase 1.2007
- Author(s)
  Hosoda S, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17(19)
  
  Pages: 5414-5418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.2006
- Author(s)
  Fujimoto H, Noguchi T, Kobayashi H, Miyachi H, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 54(6)
  
  Pages: 855-860
- NAID
  110004836392
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferators-activated receptor α/σ dual agonists.2006
- Author(s)
  J.Kasuga, M.Makishima, Y.Hashimoto, H.Miyachi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 16・3
  
  Pages: 554-558
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helic-folding inhibition hypothesis.2005
- Author(s)
  K.Hashimoto, H.Miyauchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry 13・17
  
  Pages: 5080-5093
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005
- Author(s)
  Miyachi H, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 13(17)
  
  Pages: 5080-5093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] A new class androgen receptor antagonists bearing carborane in place of a steroidal skeleton.2005
- Author(s)
  S.Fujii, Y.Hashimoto, T.Suzuki, Ohta, Y.Endo
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 15・1
  
  Pages: 227-230
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005
- Author(s)
  Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. 13・17
  
  Pages: 5080-5093
- Data Source
  KAKENHI-PROJECT-13NP0401
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis2005
- Author(s)
  Yuichi Hashimoto, et al.
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 13(17)
  
  Pages: 5080-5093
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005
- Author(s)
  Yuichi Hashimoto, 他1名
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 13・17
  
  Pages: 5080-5093
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Novel non-steroidal/non-anilide type androgen antagonists : discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligand.2005
- Author(s)
  K.Wakabayashi, H.Miyachi, Y.Hashimoto, A.Tanatani
- Journal Title
  
  Bioorganic & Medicinal Chemistry 13・8
  
  Pages: 2837-2846
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] 薬害の克服を目指した創薬化学:サリドマイドをマルチ創薬テンプレートとして活用したサリドマイドの構造展開と活性拡張2005
- Author(s)
  宮地弘幸, 橋本祐一
- Journal Title
  
  ファルマシア 41・1
  
  Pages: 33-37
- Data Source
  KAKENHI-PROJECT-15659025
[Journal Article] サリドマイドとがん治療2005
- Author(s)
  野口友美, 橋本祐一
- Journal Title
  
  がん分子標的治療 3・1
  
  Pages: 16-23
- Data Source
  KAKENHI-PROJECT-14030012
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto 他3名
- Journal Title
  
  Drugs Future 29・4
  
  Pages: 383-391
- Data Source
  KAKENHI-PROJECT-15659025
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto 他3名
- Journal Title
  
  Drugs Future 24・9
  
  Pages: 383-391
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto, 他3名
- Journal Title
  
  Drugs Future 29・4
  
  Pages: 383-391
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design2004
- Author(s)
  Yuichi Hashimoto, et al.
- Journal Title
  
  Drugs Future 29(4)
  
  Pages: 383-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto 他6名
- Journal Title
  
  Drugs Future 29・4
  
  Pages: 383-391
- Data Source
  KAKENHI-PROJECT-14030012
[Journal Article] Structural development of biological response modifiers based on retinoids and thalidomide.2002
- Author(s)
  Yuichi Hashimoto
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry 2・6
  
  Pages: 543-551
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Structural development of biological response modifiers based on retinoids and thalidomide2002
- Author(s)
  Yuichi Hashimoto
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry 2(6)
  
  Pages: 543-551
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.
- Author(s)
  Y.Hashimoto
- Journal Title
  
  Drugs Future (印刷中)
- Data Source
  KAKENHI-PROJECT-13NP0401
[Patent] C型肝炎治療剤2010
- Inventor(s)
  馬場昌範, 橋本祐一, 青山洋史, 中村政彦, 浦田泰生
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Industrial Property Number
  2010-020502
- Filing Date
  2010-02-01
- Data Source
  KAKENHI-PROJECT-19390028
[Patent] ジフェニルメタン誘導体を有効成分とする抗ウイルス剤2009
- Inventor(s)
  馬場昌範, 岡本実佳, 後藤志典, モハメドタハ, アーメドサリム, 橋本祐一, 青山洋史, 細田信之介
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Filing Date
  2009-03-13
- Data Source
  KAKENHI-PROJECT-19390028
[Patent] ベンズアルデヒド化合物2009
- Inventor(s)
  大金賢司、橋本祐一
- Industrial Property Rights Holder
  東京大学
- Industrial Property Number
  2009-148965
- Filing Date
  2009-06-23
- Data Source
  KAKENHI-PROJECT-19390028
[Patent] ベンズアルデヒド化合物2009
- Inventor(s)
  大金賢司, 橋本祐一
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2009-148965
- Filing Date
  2009-06-23
- Data Source
  KAKENHI-PROJECT-19390028
[Patent] 新規置換ビフェニルカルボン酸誘導体2009
- Inventor(s)
  宮地弘幸, 橋本祐一, 春日淳一
- Industrial Property Rights Holder
  国立大学法人岡山大学
- Industrial Property Number
  2009-132055
- Filing Date
  2009-06-01
- Data Source
  KAKENHI-PROJECT-19390028
[Patent] 三環性化合物2008
- Inventor(s)
  宮地弘幸, 橋本祐一, 青山惇
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2008-050690
- Filing Date
  2008-02-29
- Data Source
  KAKENHI-PROJECT-19390028
[Patent] 成人T細胞白血病治療薬2008
- Inventor(s)
  馬場昌範、橋本祐一、永井勝幸
- Industrial Property Rights Holder
  国立大学法人鹿児島大学
- Industrial Property Number
  2008-256620
- Filing Date
  2008-10-01
- Data Source
  KAKENHI-PROJECT-17016013
[Patent] 複素環誘導体2006
- Inventor(s)
  棚谷綾, 宮地弘幸, 中川亜弥, 橋本祐一
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2006-021770
- Filing Date
  2006-01-31
- Data Source
  KAKENHI-PROJECT-14103018
[Patent] 置換イソキサゾール誘導体2006
- Inventor(s)
  宮地弘幸, 貝沼雅彦, 橋本祐一
- Industrial Property Rights Holder
  国立大学法人東京大学
- Industrial Property Number
  2006-054501
- Filing Date
  2006-03-01
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Presentation] 独自の創薬手法・戦略に基づく生物応答調節剤の創製研究2020
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第140年会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] コレステロール合成酵素SMのフィードフォワード制御因子としてのスクアレン2020
- Author(s)
  吉岡広大、Hudson W. Coates、Ngee Kiat Chua、橋本祐一、Andrew J. Brown、大金賢司
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] HMG-CoA還元酵素分解誘導剤SR12813の光親和性標識プローブ化2020
- Author(s)
  豊田洋介、吉岡広大、鷺森郁也、橋本祐一、大金賢司
- Organizer
  日本薬学会第140年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] リン原子の創出する構造多様性に着目した生物活性化合物の創成研究（ホスフィノフェノール誘導体の構造物性相関とERリガンド活性）2019
- Author(s)
  斎藤広樹、松本雄一朗、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第14会年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ジフェニルホスフィン構造を基盤とした含リン化合物の性質の解明と医薬品構造要素としての有用性の検討2019
- Author(s)
  齊藤広樹、松本雄一朗、橋本祐一、影近弘之、藤井晋也
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] Development of novel silicon-containing transcription modulators including sila-heterocyclic compounds.2019
- Author(s)
  H. Toyama, D. Kajita, Y. Hashimoto, S. Fujiii
- Organizer
  BIOHETEROCYCLES 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] Development of bioactive compounds based on bis-aryl (6-X-Y-6) skeleton.2019
- Author(s)
  T. Noguchi-Yachide, K. Ohgane, Y. Hashimoto
- Organizer
  BIOHETEROCYCLES 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] HMG-CoA還元酵素の分解を誘導する低分子化合物の構造活性相関とプローブ化2018
- Author(s)
  鷺森郁也、吉岡広大、橋本祐一、大金賢司
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ER downregulationの母格横断的な構造活性相関2018
- Author(s)
  南條舜、谷内出友美、吉岡広大、槇島誠、石川稔、橋本祐一、大金賢司
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ERダウンレギュレーターの構造活性相関2018
- Author(s)
  谷内出友美、南條舜、大金賢司、橋本祐一
- Organizer
  日本レチノイド研究会第29会学術集会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ビスフェノール構造を基盤としたケイ素官能基の構造物性および構造活性相関2018
- Author(s)
  松本雄一朗、橋本祐一、藤井晋也
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] ケイ素官能基をリンカー構造とするビスフェノール誘導体の構造物性相関と選択的エストロゲン受容体モジュレータへの展開2018
- Author(s)
  松本雄一朗、橋本祐一、藤井晋也
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Development of dual BRD4/HDAC inhibitors.2018
- Author(s)
  Tomomi Noguchi-Yachide, Seika Amemiya, Takao Yamaguchi, and Yuichi Hashimoto
- Organizer
  54th International Conference on Medicinal Chemistry (RICT 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ケイ素官能基をリンカー構造とするビスフェノール誘導体の構造物性相関と選択的エストロゲン受容体モジュレータへの展開2018
- Author(s)
  松本雄一朗、橋本祐一、藤井晋也
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] Silyl groups as fancy isosteres of cis-diatomic functionalities: Development of novel nuclear receptor modulators bearing silyl functionality2018
- Author(s)
  Shinya Fujii, Hirosumi Toyama, Daisuke Kajita, Yuichi Hashimoto
- Organizer
  RICT 2018 54th International Conference on Medicinal Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Silyl groups as fancy isosteres of cis-diatomic functionalities (Development of novel nuclear receptor modulators bearing silyl functionality)2018
- Author(s)
  Shinya Fujii, Hirosumi Toyama, Daisuke Kajita, and Yuichi Hashimoto
- Organizer
  54th International Conference on Medicinal Chemistry (RICT 2018)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ItraconazoleのNPC1シャペロンとしての構造活性相関研究2018
- Author(s)
  安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] Transrepression作用選択的PPARγリガンドの創製を指向した構造活性相関研究2018
- Author(s)
  豊田洋介、野村さやか、槇島誠、橋本祐一、石川稔
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] イトラコナゾールのNPC1に対するシャペロン作用に着目した構造活性相関研究2018
- Author(s)
  安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 創薬化学における高周期元素の利用法の検討－種々の元素をリンカー構造に有するビスフェノール誘導体の構造物性相関および構造活性相関2018
- Author(s)
  松本雄一朗、橋本祐一、藤井晋也
- Organizer
  日本レチノイド研究会第29会学術集会
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] ホスフィネノール構造を基盤とする含リン化合物の構造物性相関と生物活性化合物への応用2018
- Author(s)
  齊籐広樹、松本雄一朗、橋本祐一、藤井晋也
- Organizer
  第36回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 神経変性疾患原因タンパク質のケミカルノックダウン2017
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 神経変性疾患関連凝集タンパク質分解誘導剤の開発2017
- Author(s)
  山下博子、友重秀介、野村さやか、大金賢司、橋本祐一、石川稔
- Organizer
  日本ケミカルバイオロジー学会第12会年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] パーフルオロアルコール基の代替官能基としてのシラノール基の医薬的有用性の検討2017
- Author(s)
  外山大純、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第12会年会
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Phenanthridin-6(5H)-one骨格を有する非ステロイド型プロゲステロン受容体拮抗薬の創製2017
- Author(s)
  西山郵子、森修一、槇島誠、藤井晋也、影近弘之、橋本祐一、石川稔
- Organizer
  日本レチノイド研究会第28会学術集会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ドラッグリポジショニングによるニーマンピック病Ｃ型に対するシャペロンドラッグの探索2017
- Author(s)
  (2)大金賢司、塩井隆太、安藤勇輝、谷内出友美、石川稔、どど幸介、袖岡幹子、橋本祐一
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 新規アンドロゲン受容体AF-1モジュレーターの構造活性相関．2016
- Author(s)
  沼館慧剛、梅田香織、槇島誠、橋本祐一、藤井晋也
- Organizer
  日本レチノイド研究会第27回学術集会
- Place of Presentation
  昭和薬科大学（東京都町田市）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Structural and functional development of retinoids/steroids.2016
- Author(s)
  Yuichi Hashimoto
- Organizer
  International Conference for the 70th Anniversary of Pharmaceutical Society of Korea
- Place of Presentation
  The-K Hotel Seoul（韓国）
- Year and Date
  2016-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] 新規BRD4/HDAC二重阻害活性化合物の創製．2016
- Author(s)
  雨宮聖花、山口卓男、境太希、橋本祐一、谷内出友美
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 小分子による蛋白変性疾患制圧のこころみ．2016
- Author(s)
  橋本祐一
- Organizer
  創薬懇話会 2016
- Place of Presentation
  エクシブ蓼科（長野県茅野市）
- Invited
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] AF-1領域による機能制御を指向した新規アンドロゲン受容体モジュレーターの創製2016
- Author(s)
  沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] N6-ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製研究．2016
- Author(s)
  谷内出友美、橋本祐一
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  大分県別府市別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 核内受容体リガンドを指向した1,3,5-トリアジン誘導体の設計と構造展開2016
- Author(s)
  海東和麻、谷内出友美、中津亜紀、森修一、橋本祐一、影近弘之、藤井晋也
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Structural and functional development of retinoids/steroids.2016
- Author(s)
  Yuichi Hashimoto
- Organizer
  International Conference for the 70th Anniversary of Pharmaceutical Society of Korea
- Place of Presentation
  The-K Hotel Seoul（韓国）
- Year and Date
  2016-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出．2016
- Author(s)
  山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] ハンチントン病原因タンパク質の分解誘導薬の創製．2016
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] アンドロゲン受容体AF-1モジュレーターの構造展開．2016
- Author(s)
  沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製2016
- Author(s)
  雨宮聖花、境太希、橋本祐一、山口卓男、谷内出友美
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Huntingtinタンパク質を減少させるSNIPER化合物の創製2016
- Author(s)
  友重秀介、大金賢司、内藤幹彦、石川稔、橋本祐一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出．2016
- Author(s)
  吉岡広大、西山郵子、山田歩、影近弘之、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] 新規骨格構造を有する非ステロイド型GRリガンドの探索と構造展開．2016
- Author(s)
  吉岡広大、西山郵子、山田歩、影近弘之、橋本祐一、藤井晋也
- Organizer
  日本レチノイド研究会第27回学術集会
- Place of Presentation
  昭和薬科大学（東京都町田市）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Design and synthesis of novel ROR inverse agonists based on silicon-containing hetgerocyclic core structure2015
- Author(s)
  H. Toyama, M. Nakamura, Y. Hashimoto, S. Fujii
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and optimization of distinctive nuclear receptors modulators (I): Inhibitors of the interaction of VDR with coactivators, and nuclear receptors-degradation inducers2015
- Author(s)
  Minoru Ishikawa, Yusuke Mita, Yukihiro Itoh, Risa Kitaguchi, Makoto Makishima, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Transrepression作用選択的なLXRリガンドの創製2015
- Author(s)
  野村さやか、遠藤（梅田）香織、青山惇、槇島誠、橋本祐一、石川稔
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of transrepression-selective liver X receptor (LXR) ligands2015
- Author(s)
  S. Nomura, K. Endo-Umeda, A. Aoyama, M. Ishikawa, M. Makishima, Y. Hashimoto
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Novel BRD4 inhibitors with a N6-benzoyladenine skeleton2015
- Author(s)
  T. Noguchi-Yachide, T. Sakai, Y. Hashimoto, T. Yamaguchi
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Retinoids/steroids as ligands for pharmacological chaperons and protein knockdown approach2015
- Author(s)
  Yuichi Hashimoto
- Organizer
  AIMECS 2015 (10th AFMC International Medicinal Chemistry Symposium), Oct. 18-21, 2015 (Korea, ICC JELU)
- Place of Presentation
  Korea, ICC JELU
- Year and Date
  2015-10-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Retinoids/steroids as ligands for pharmacological chaperons and protein knockdown approach2015
- Author(s)
  Yuichi Hashimoto
- Organizer
  RICT 2015 (Rencontres Internationales de Chimie Therapeutique)
- Place of Presentation
  Avignon, France
- Year and Date
  2015-07-01
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] フェナンスリジノン骨格を有するステロイドホルモン受容体リガンドの創製2015
- Author(s)
  西山郵子、藤井晋也、石川稔、橋本祐一、槇島誠
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of silicon-based biological active compounds by focusing on silyl functionality as a cis-olefin mimetic2015
- Author(s)
  D. Kajita, M. Nakamura, Y. Matsumoto, M. Ishikawa, Y. Hashimoto, S. Fujii
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015
- Author(s)
  岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓男
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and optimization of distinctive nuclear receptor modulators (II): Transrepression selective LXR ligands, and LXRβ selective agonists2015
- Author(s)
  Minoru Ishikawa, Sayaka Nomura, Atsushi Aoyama, Kaori Endo-Umeda, Kazunori Motoshima, Makoto Makishika, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Polypharmacological profiles of phenathridinone derivatives2015
- Author(s)
  Y. Nishiyama, T. Misawa, H. Aoyama, S. Fujii, M. Ishikawa, Y. Hashimoto
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of androgen receptor (AR) activation function-1 (AF-1) modulators2015
- Author(s)
  Shinya Fujii, Akiyoshi Numadate, Tomomi Noguchi-Yachide, Kaori Endo-Umeda, Makoto Makishima, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] マルチテンプレート手法を用いた新規TGR5 リガンドの創製研究2014
- Author(s)
  小針孝夫、三澤隆史、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] NPC1 の局在異常を修正する非ステロイド性リガンドの創製研究2014
- Author(s)
  福田寛充、大金賢司、唐木文霞、闐闐孝介、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 膠芽腫幹細胞を標的としたsirtuin2 阻害剤の創製研究2014
- Author(s)
  境太希、若井信彦、松本洋太郎、林寛敦、石川稔、杉田和幸、北尾彰朗、秋山徹、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 神経変性疾患原因タンパク質分解誘導剤の創製研究2013
- Author(s)
  友重秀介、北口梨沙、大金賢司、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Retinoids as ligands for pharmaceutical chaperone and protein knockdown approach2012
- Author(s)
  Y. Hashimoto
- Organizer
  The 1st International Symposium on Latent TGF-βActivation Reaction
- Place of Presentation
  Kobe
- Year and Date
  2012-02-25
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteosomal degradation of target protein2012
- Author(s)
  M. Naito, K. Okuhira, N. Ohoka, N. Shibata, T. Hattori, Y. Itoh, M. Ishikawa, Y. Hashimoto
- Organizer
  The Sixth International Conference. SUMO, Ubiquitin, UBL Proteins
- Place of Presentation
  Houston
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] PFIC2 の原因となる変位型BSEP の機能を修正する新規小分子の発見と構造展開2012
- Author(s)
  三澤隆史、林久允、杉山雄一、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] タンパク質ノックダウン法を利用した新治療戦略と低分子の標的タンパク質同定法2012
- Author(s)
  石川稔、どど孝介、伊藤幸裕、淺沼三和子、佐藤伸一、袖岡幹子、内藤幹彦、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012
- Author(s)
  谷内出友美、杉田和幸、松本洋太郎、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] NPC1 変異体のフォールディング効率低下をrescue するステロール誘導体の発見、およびNPC1 の第二のステロール結合部位の存在2012
- Author(s)
  大金賢司、唐木文霞、闐闐孝介、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Retinoids as ligands for pharmaceutical chaperone and protein knockdown approach2012
- Author(s)
  Yuichi Hashimoto
- Organizer
  The 1st International Symposium on Latent TGF-β Activation Reaction
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2012-02-25
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012
- Author(s)
  青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
- Organizer
  日本レチノイド研究会第23回学術集会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Pharmacological chaperones and protein knockdown inducers derived from nuclear receptor ligands2012
- Author(s)
  Y.Hashimoto
- Organizer
  The 23^<rd> Symposium of Retinoids
- Place of Presentation
  Yonago
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] プロテインノックダウン法を利用した核内受容体分解誘導低分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 核内受容体を細胞内で選択的に分解誘導する分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本レチノイド研究会第22回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein knockdown : selective degradation of target proteins in cells using methyl bestatin-ligand hybrid molecules2011
- Author(s)
  M. Ishikawa, Y. Itoh, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Organizer
  AIMECS 2011
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の検討2011
- Author(s)
  奥平桂一郎、大岡伸通、最上(西巻)知子、橋本祐一、内藤幹彦
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] タンパク質の形と存在状態を狙う生理活性物質の創製2011
- Author(s)
  橋本祐一
- Organizer
  平成23年度後期(秋季)有機合成化学講習会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] タンパク質の形と存在状態を狙う生理活性物質の創製2011
- Author(s)
  橋本祐一
- Organizer
  平成23年度後期(秋季)有機合成化学講習会
- Place of Presentation
  東京
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] プロテインノックダウン法の開発～低分子CRABP分解誘導剤の創製～2010
- Author(s)
  伊藤幸裕, 石川稔, 内藤幹彦, 橋本祐一
- Organizer
  第8回次世代の担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton2010
- Author(s)
  K.Maruyama, M.Ishikawa, T.Noguchi-Yachide, Y.Hashimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] ケミカルジェネティクスと創薬のための活性物質創製法2010
- Author(s)
  橋本祐一
- Organizer
  創薬懇話会2009
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discoveryof CRABP degradation inducers.2010
- Author(s)
  Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] ニーマンピック病C型の原因となるNPC1 変異体のフォールディング・トラフィッキング異常を修正する低分子化合物の発見と構造活性相関2010
- Author(s)
  大金賢司、闐闐孝介、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究---網膜色素変性症への応用を目指して---2010
- Author(s)
  大金賢司、どど孝介、橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] プロテインノックダウン法の開発2010
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第8回次世代を担う有機科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] プロテインノックダウン法を利用したAR 分解誘導剤の創製2010
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Multi-template and dramatype approaches for lead generation2010
- Author(s)
  橋本祐一
- Organizer
  第3回高度医療都市を創出する未来技術国際シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] Multi-template and dramatype approaches for lead generation.2010
- Author(s)
  橋本祐一
- Organizer
  第3回高度医療都市を創出する未来技術国際シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製2010
- Author(s)
  石川稔、伊藤幸裕、内藤幹彦、橋本祐一
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～網膜色素変性症への応用を目指して～2010
- Author(s)
  大金賢司, 〓〓孝介, 橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] プロテインノックダウン法を利用した創薬指向型CRABP分解誘導剤の創製2010
- Author(s)
  伊藤幸裕、石川稔、奥平桂一郎、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2010
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法.2010
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2010
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discovery of CRABP degradation inducers2010
- Author(s)
  Y.Itoh, M.Ishikawa, M.Naito, Y.Hashimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] フタルイミド骨格を基盤としたトリプターゼ阻害剤の創製2009
- Author(s)
  鉄橋正士、橋本祐一、青山洋史
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 3,3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009
- Author(s)
  谷内出友美、鉄橋正士、青山洋史、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] マルチテンプレート手法とドラマタイプ手法に基づく生物活性物質の創製2009
- Author(s)
  橋本祐一
- Organizer
  日本化学会第3回関東支部大会
- Place of Presentation
  東京
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～網膜色素変性症への応用を目指して～2009
- Author(s)
  大金賢司、どど孝介、橋本祐一
- Organizer
  日本レチノイド研究会第20回学術集会
- Place of Presentation
  東京
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 3, 3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009
- Author(s)
  谷内出友美、鉄橋正士、青山洋史、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] ケミカルジェネティクスと創薬のための活性物質創製法2009
- Author(s)
  橋本祐一
- Organizer
  創薬懇話会2009
- Place of Presentation
  岐阜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 変異型ロドプシンのフォールディングを促進する低分子化合物による網膜色素変性症治療薬創製研究2009
- Author(s)
  大金憲司、〓〓孝介、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～網膜色素変性症への応用を目指して～2009
- Author(s)
  大金賢司、どど孝介、橋本祐一
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2009
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岐阜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] マルチテンプレート手法とドラマタイプ手法に基づく生物活性物質の創製2009
- Author(s)
  橋本祐一
- Organizer
  日本化学会第3回関東支部大会
- Place of Presentation
  東京
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] ネクローシスの分子機構解明を目指した新規細胞死誘導剤の創製2009
- Author(s)
  佐藤伸一、どど孝介、滕玉鴎、橋本祐一、袖岡幹子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] ステロイド代替骨格として機能するジフェニルペンタン誘導体の創製---核内受容体リガンドとHMG-CoA還元酵素阻害剤---2008
- Author(s)
  細田信之介、松田大介、供田洋、橋本祐一
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] Biological response modifiers derived from thalidomide.2007
- Author(s)
  Yuichi Hashimoto
- Organizer
  The 12th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Year and Date
  2007-12-04
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] Biological response modiifiers derived from thalidomide2007
- Author(s)
  Yuichi Hashimoto
- Organizer
  The 12^th Japanese Foundation for Chncer Research International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Year and Date
  2007-12-04
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] ケイ素とcisオレフィンの可換性に着目した含ケイ素PPARアゴニストの創製
- Author(s)
  梶田大資、中村雅陽、松本洋太郎、石川稔、橋本祐一、藤井晋也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 含ケイ素抗エストロゲン様活性物質の創製
- Author(s)
  梶田大資、中村雅陽、松本洋太郎、橋本祐一
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] ステロイド代替骨格としてのジフェニルメタン骨格～胆汁鬱滞性疾患治療薬への展開～
- Author(s)
  小針孝夫、細田信之介、貝沼雅彦、三澤隆、藤井晋也、橋本祐一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 核内受容体選択的なCoactivator Binding Inhibitorの創製研究
- Author(s)
  福田寛充、槇島誠、石川稔、藤井晋也、橋本祐一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Transrepression作用選択的なスチニルフェニルフタルイミド骨格を有するLXRリガンドの創製
- Author(s)
  野村さやか、石川稔、槇島誠、青山惇、橋本祐一
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第32回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第32回メディシナルケミストリ－シンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-25670052
[Presentation] LXR（Liver X Receptor）β選択的アゴニストの創製
- Author(s)
  野村さやか、石川稔、橋本祐一、梅田（遠藤）香織、槇島誠
- Organizer
  第32回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293025

1. KAGECHIKA Hiroyuki (20177348)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
2. ENDO Yasuyuki (80126002)

# of Collaborated Projects: 9 results

# of Collaborated Products: 1 results
3. IWASAKI Shigeo (00013326)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
4. SHUDO Koichi (50012612)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
5. KOBAYASHI Hisayoshi (80225531)

# of Collaborated Projects: 9 results

# of Collaborated Products: 2 results
6. NOGUCHI Tomomi (20401284)

# of Collaborated Projects: 5 results

# of Collaborated Products: 32 results
7. KOISO Yuikiko (50092200)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
8. SHIRAI Ryuichi (80183838)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. OHWADA Tomohiko (20177025)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. NAGASAWA Kazuo (10247223)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. ISHIKAWA Minoru (70526839)

# of Collaborated Projects: 3 results

# of Collaborated Products: 56 results
12. FUJII Shinya (60389179)

# of Collaborated Projects: 3 results

# of Collaborated Products: 42 results
13. MORISAKI Naoko (00092354)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. 大野竜三 (70093002)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
15. 本間良夫 (70142114)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. 武藤泰敏 (20010069)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
17. 直江知樹 (50217634)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. AOYAMA Hiroshi (40374699)

# of Collaborated Projects: 2 results

# of Collaborated Products: 9 results
19. 藤木博太 (60124426)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 深見泰夫 (00156746)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 野瀬清 (70012747)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. 大内和雄 (20006357)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. 垣塚彰 (80204329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. 袖岡幹子 (60192142)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
25. SUGITA Kazuyuki (60542090)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
26. MATSUMOTO Yotaro (90420041)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
27. MISAWA Takashi (40709820)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
28. MIYACHI Hiroyuki (20376643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
29. TANATANI Aya (40361654)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
30. 石川隆俊 (30085633)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 上村大輔 (00022731)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. 柴崎正勝 (30112767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 梅沢一夫 (70114402)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 鈴木正昭 (90093046)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 渡辺恭良 (40144399)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 松田彰 (90157313)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 石川智久 (60193281)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 伊藤誠二 (80201325)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 萩原正敏 (10208423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 根岸学 (60201696)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 鈴木和年 (90162932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 米倉義晴 (60135572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 森望 (00130394)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 長野哲雄 (20111552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 浦野泰照 (20292956)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 大金賢司

# of Collaborated Projects: 0 results

# of Collaborated Products: 9 results
47. 内藤幹彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
48. 山口卓男

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
49. 白川仁

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
50. 駒井三千夫

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
51. 秋山徹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
52. 北尾彰朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
53. 伊藤幸裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
54. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

HASHIMOTO Yuichi 橋本 祐一

橋本 裕一 ハシモト ユウイチ

橋本 祐一 ハシモト ユウイチ

Research Projects

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Co-Researchers

Structural and functional development studies of ligands for disease progression factorsPrincipal Investigator

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Development of silicon-containing units as expanded bioisostersPrincipal Investigator

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Polypharmacology based on dynamism of the target proteinPrincipal Investigator

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Chemical biology of trafficking regulation of membrane cholesterol transporter proteinPrincipal Investigator

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Chemical control of protein dramatypePrincipal Investigator

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Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target ProteinsPrincipal Investigator

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Biological response modification based on multi-template and dramatype approaches.Principal Investigator

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Thalidomide as a cell differentiation regulator

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Development of anti-tumor agents based on biological response modification.Principal Investigator

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サリドマイドの抗糖尿病薬への展開Principal Investigator

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がん増悪因子を阻害する医薬リードの創製Principal Investigator

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Design and development of biological response modifiersPrincipal Investigator

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サリドマイドの構造展開による、がん増悪因子を阻害する医薬リードの創製Principal Investigator

Principal Investigator

HASHIMOTO Yuichi 橋本祐一

橋本裕一ハシモトユウイチ

橋本祐一ハシモトユウイチ