Hashimoto Yuichi 橋本祐一

… Alternative Names

Researcher Number	90164798
Other IDs
External Links
Affiliation (Current)	2019 : 東京大学, 定量生命科学研究所, 教授
Affiliation (based on the past Project Information) *help	2018 – 2019 : 東京大学, 定量生命科学研究所, 教授 1997 – 2017 : THE UNIVERSITY OF TOKYO,Insititute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授 1993 – 1996 : 東京大学, 分子細胞生物学研究所, 助教授 1995 : 東京大学, 分生研, 助教授 1990 – 1992 : 東京大学, 応用微生物研究所, 助教授 … More
Review Section/Research Field	Principal Investigator Drug development chemistry / Chemical pharmacy / Biological Sciences / 医薬分子機能学 / Living organism molecular science Except Principal Investigator Chemical pharmacy / 医薬分子機能学 / Drug development chemistry
Keywords	Principal Investigator サリドマイド / 構造展開 / レチノイド / フタルイミド / 構造活性相関 / 阻害剤 / 核内受容体 / アンタゴニスト / 抗アンドロゲン / 核内受容体リガンド … More Except Principal Investigator レチノイド / レチノイン酸 / チューブリン / 有糸分裂阻害剤 / 分化誘導 / レチノイドアンタゴニスト / キュラシンA / ウスチロキシン / 急性前骨髄球性白血病 / レセプター / 分化 / ビタミンA / アンタゴニスト / 微小管機能 / アレナスタチンA / differentiation / retinoic acid / HL60 / 分化誘導療法 / オカダ酸 / 癌 / 細胞分化 / リウマチ / Rhizoxin / オカダ酸クラス発がんプロモ-タ- / 有糸分裂 / Am-80 / 細胞内レチノイン酸結合蛋白 / Maytansine部位 / retinoid / leukemia / チュ-ブリン / 形態形成 / Phomopsin A / サリドマイド / 血管新生 / 血管新生阻害 / 複合体構造 / PML / 分子設計 / レチノイドレセプタ- / ビタミンA酸 / 分子認識機構 / ミクロチスチン / 転移 / 白血病 / レチノイン酸レセプター / 分子認識 / JE遺伝子 / メイタンシン / アラキドン酸 / molecular design / 3成分連結PG合成法 / antimitotic agent / retinoid antagonist / antagonist synergist / 構造活性相関 / RARA / 阻害剤 / カルコンカルボン酸・分化 / 神経性疼痛 / チロキシン / vitamin A / 4'-チオリボヌクレオシド / ジベンゾジアゼピン / プロスグランジン / 活性評価 / α-グルコシダーゼ / 腫瘍壊死因子(TNF)-α / 光親和性標識法 / 神経因性疼痛 / チロイドリセプター / レ-デオキシアデノシン / 蛍光プローブ / Lーアラビノ-ス / シグナル解析 / 微小管 / リセプタータンパク / 人工核酸 / チロイド / 核内受容体 / ブファリン / 亜砒酸 / VLB / DNAチップ / Cu-ATSM / チューブリン重合阻害 / プラナーポジトロンイメージング / シクロオキシゲナーゼ / protein kinase C / 可視化プローブ / テレフタル酸アリリド / ダントロレン誘導体 / TRE / RXRアンタゴニスト / 精密構造認識 / ベンゾラクタム / トランスジェニック・マウス / curacin A / action mechanism / CNーTPBP / 作用機作 / 15R-TIC / キナーゼ阻害剤 / フオルボール / 核レセプター / 制がん剤 / cancer / PET / retinoid receptor / X線結晶解析 / キナーゼ / 癌治療薬 / レチノイドレセプター / ポリプレン酸 / non-RI光親和性標識法 / 酸異性化 / ステロイド / プロスタグランジンE_2 / arenastatin A / 核内レセプタ- / 三重鎖 / 34mCl / MicroPET / リアノジン受容体 / tubulin / ユビキチン・プロテアゾーム / Socius / がん / プロティンフォスファタ-ゼ / ABCトランスポーター / Dolastatin 10 / tyroids / Ustiloxin / 核内レセプター / myeloma / 核中レセプター / 癌治療 / プロテインキナ-ゼC / リゾキシン / 分子誘導療法 / レチイン酸 / 乾癖 / MAY部位 / ustiloxins / 代謝物 / 腫瘍悪性化 / PGE_2 / アロディニア / 構造展開 / 分子進化 / 核レセプタ- / アンチセンスDNA / 高速メチル化 / LiverX受容体(LXR) / 蛋白質脱リン酸化酵素2A / リピドA / (dA)_6 / シリコン / 細胞増殖阻害 / 生物活性物質 / チロキシンレセプター / 転移抑制 / 鶏卵法検定 Less

疾病増悪因子リガンドの構造展開と機能展開Principal InvestigatorOngoing
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
ケイ素の拡張型バイオアイソスターとしての新たな展開Principal InvestigatorOngoing
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Polypharmacology based on dynamism of the target proteinPrincipal Investigator
- Principal Investigator
  
  Hashimoto Yuichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Chemical biology of trafficking regulation of membrane cholesterol transporter proteinPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Chemical control of protein dramatypePrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2010 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target ProteinsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  The University of Tokyo
Biological response modification based on multi-template and dramatype approaches.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Thalidomide as a cell differentiation regulator
- Principal Investigator
  
  NOGUCHI Tomomi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
Development of anti-tumor agents based on biological response modification.Principal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2005 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
サリドマイドの抗糖尿病薬への展開Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  The University of Tokyo
がん増悪因子を阻害する医薬リードの創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Design and development of biological response modifiersPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
サリドマイドの構造展開による、がん増悪因子を阻害する医薬リードの創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
生物新機能と創薬をめざす生体内分子科学
- Principal Investigator
  
  鈴木正昭
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Gifu University
サリドマイドの構造展開による,がん増悪因子を阻害する医薬リードの創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
ホルモンとしてのサリドマイド・・・細胞検定を指標にした構造展開Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
生物応答調節剤による発がん過程の修飾と予防Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
生物応答調節分子の設計と活性発現機構Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Structural development of bio-active compounds affecting nuclear receptor functionPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1998 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
生物応答調節分子の設計と活性発現機構Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
微小管機能を制御する超分子形成とリガンド機能の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
エンドペプチダーゼ組み合わせ法によるレセプターラベル部位の決定Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん細胞分化機構の分子生物学的解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
レチノイドの化学・生物学・医学研究
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulatorsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
発癌プロモーターとレチノイドのクロストークPrincipal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
がん細胞分化機構の分子生物学的の解明と分化誘導療法の臨床応用に関する基礎的研究
- Principal Investigator
  
  大野竜三
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hamamatsu University School of Medicine
フタルイミド系新規TNF(腫瘍壊死因子)産生抑制剤の創製Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  The University of Tokyo
Preparation of Functional Polylipid BiofactorsPrincipal Investigator
- Principal Investigator
  
  HASHIMOTO Yuichi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Chemical pharmacy
- Research Institution
  THE UNIVERSITY OF TOKYO
デキストラン法による脂溶性分子の水溶液中での挙動解析Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
Regulatory compound of nuclear receptor functions.
- Principal Investigator
  
  SHUDO Koichi
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  University of Tokyo, Faculty of pharm.Sciences
非細胞傷害性抗がん化合物の合成と作用解析
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
発がんプロモーターの校内レセプターPrincipal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
有糸分裂阻害剤-チューブリン間の精密構造認識の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
アンチセンス/エナンチオDNAPrincipal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Chemical pharmacy
- Research Institution
  The University of Tokyo
発がんプロモ-タ-の核内レセプタ-Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
- Principal Investigator
  
  岩崎成夫
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
- Principal Investigator
  
  IWASAKI Shigeo
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
核内レセプタ-応答遺伝子の認識分子
- Principal Investigator
  
  SHUDO Koichi
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
臨床応用を目指すレチノイドの研究
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Molecular design and synthesis of new retinoids
- Principal Investigator
  
  SHUDO Koichi
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Chemical pharmacy
- Research Institution
  Univ. of Tokyo
発がんプロモ-ションの機構とその阻害
- Principal Investigator
  
  藤木博太
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
発がんプロモ-ションの機構とその阻害
- Principal Investigator
  
  藤木博太
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
新しい作用機作をもつ抗がん剤の合成と特性
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
ビタミンA酸および関連化合物による分化誘導とその作用機作
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新しい作用機作をもつ抗がん剤の合成と特性
- Principal Investigator
  
  首藤紘一
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
化学発癌物質によるオンコジンの化学修飾と活性化Principal Investigator
- Principal Investigator
  
  橋本祐一
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo

[Book] 生体有機化学2012
- Author(s)
  橋本祐一・村田道雄　編著
- Total Pages
  215
- Publisher
  東京化学同人
- Data Source
  KAKENHI-PROJECT-22249006
[Book] Interaction of biological response modifier with proteins. In "Protein Targeting with Small Molecules: Chemical Biology Techniques and Applications"(ed. By Osada H)2009
- Author(s)
  Hashimoto Y
- Publisher
  (John Wiley & Sons, New Jersey)
- Data Source
  KAKENHI-PROJECT-19390028
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆)
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆), 半田宏編
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Data Source
  KAKENHI-PROJECT-15659025
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆), 半田宏編
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Data Source
  KAKENHI-PROJECT-14103018
[Book] ケミカルバイオロジー・ケミカルゲノミクス2005
- Author(s)
  橋本祐一(分担執筆), 半田宏編
- Total Pages
  278
- Publisher
  シュプリンガー・フェアラーク東京
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Degradation of huntingtin mediated by a hybrid molecule composed of IAP antagonist linked to phenyldiazenyl benzothiazole derivative2018
- Author(s)
  Shusuke Tomoshige, Sayaka Nomura, Kenji Ohgane, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganig and Medicinal Chemistry Letters
  
  Volume : 28 Pages : 707-710
- DOI
  10.1016/j.bmcl.2018.01.012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Structural development of tetrachlorophthalimides as liver X receptor β (LXRβ)-selective agonists with improved aqueous solubility2018
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Shinya Fujii, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganig and Medicinal Chemistry Letters
  
  Volume : 28 Pages : 796-801
- DOI
  10.1016/j.bmcl.2017.12.024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Development of nonsteroidal glucocorticoid receptor modulators based on N -benzyl- N -(4-phenoxyphenyl)benzenesulfonamide scaffold2017
- Author(s)
  Yoshioka Hiromasa、Yamada Ayumi、Nishiyama Yuko、Kagechika Hiroyuki、Hashimoto Yuichi、Fujii Shinya
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 25 Pages : 3461-3470
- DOI
  10.1016/j.bmc.2017.04.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15138
[Journal Article] Phenanthridin-6-one derivatives as the first class of non-steroidal pharmacological chaperones for Niemann-Pick disease type C1 protein2017
- Author(s)
  Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
- Journal Title
  
  Bioorganig and Medicinal Chemistry Letters
  
  Volume : 27 Pages : 2781-2787
- DOI
  10.1016/j.bmcl.2017.04.062
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15487, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015
[Journal Article] Structure-activity relationships of rosiglitazone for peroxisome proliferator-activated receptor gamma transrepression2017
- Author(s)
  Yosuke Toyota, Sayaka Nomura, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganig and Medicinal Chemistry Letters
  
  Volume : 27 Pages : 2776-2780
- DOI
  10.1016/j.bmcl.2017.04.061
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996
[Journal Article] Synthesis and evaluation of novel dual BRD4/HDAC inhibitors2017
- Author(s)
  Amemiya Seika、Yamaguchi Takao、Hashimoto Yuichi、Noguchi-Yachide Tomomi
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 25 Pages : 3131-3134
- DOI
  10.1016/j.bmc.2017.04.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists2017
- Author(s)
  Ryuta Shioi, Shogo Okazaki, Tomomi Noguchi-Yachide, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 27 Pages : 3131-3134
- DOI
  10.1016/j.bmcl.2017.05.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-17H03996, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K17930
[Journal Article] Progress in the medicinal chemistry of silicon: C/Si exchange and beyond2017
- Author(s)
  Fujii Shinya、Hashimoto Yuichi
- Journal Title
  
  Future Med. Chem.
  
  Volume : 9 Pages : 485-505
- DOI
  10.4155/fmc-2016-0193
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-17H03997, KAKENHI-PROJECT-16K15138
[Journal Article] Structure-activity relationship study of N6-benzoyladenine-type BRD4 inhibitors and their effects on cell differentiation and TNF-α production.2016
- Author(s)
  Seika Amemiya, Takao Yamaguchi, Taki Sakai, Yuichi Hashimoto, Tomomi Nogichi-Yachide
- Journal Title
  
  Chemal and Pharmaceutical Bulletin
  
  Volume : 64 Pages : 1378-1383
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293025
[Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.2016
- Author(s)
  Hirozumi Toyama, Shoko Sato, Hitoshi Shirakawa, Michio Komai, Yuichi Hashimoto, Shinya Fujii
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume : 26 Pages : 1817-1820
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15137
[Journal Article] Development of tetrachlorophthalimides as liver X receptor β (LXRβ)－selective agonists.2016
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  ChemMedChem.
  
  Volume : 11 Pages : 2347-2360
- DOI
  10.1002/cmdc.201600305
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Discovery of N-(1-(3-(4-phenoxyphenyl)-1,2,4-oxadiazol-5-yl)ethyl)acetamices as novel acetyl-CoA carboxylase 2 (AAC2) inhibitors with peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonistic activity.2016
- Author(s)
  Shogo Okazaki, Tomomi Noguchi-Yachide, Taki Sakai, Minoru Ishikawa, Makoto Makishima, Yuichi Hashimoto, Takao Yamaguchi
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume : 24 Pages : 5258-5269
- DOI
  10.1016/j.bmc.2016.08.045
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-16K15137, KAKENHI-PROJECT-16K17930
[Journal Article] Altered activity profile of a tertiary silanol analog of multi-targeting nuclear receptor modulator T0901317.2016
- Author(s)
  Toyama H, Sato S, Shirakawa H, Komai M, Hashimoto Y, Fujii, S.
- Journal Title
  
  Bioorganic and Medicinal Chemistry Letters
  
  Volume : 26 Pages : 1817-1820
- DOI
  10.1016/j.bmcl.2016.02.031
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26292063, KAKENHI-PROJECT-26293025
[Journal Article] Efficient protein knockdown of HaloTag-fused proteins using hybrid molecules consisting of IAP antagonist and HaloTag ligand.2016
- Author(s)
  Shusuke Tomoshige, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Bioorganic and Medicinal Chemistry
  
  Volume : 24 Pages : 3144-3148
- DOI
  10.1016/j.bmc.2016.05.035
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-16K15137
[Journal Article] Discovery and structure-activity relationship studies of N6-benzoyladenine derivatives as novel BRD4 inhibitors2015
- Author(s)
  Noguchi-Yachide, T., Sakai, T., Hashimoto, Y., Yamaguchi, Y.
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 23 Pages : 953-959
- DOI
  10.1016/j.bmc.2015.01.022
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26293025, KAKENHI-PROJECT-26810091, KAKENHI-PROJECT-15K08015
[Journal Article] Design and synthesis of novel ROR inverse agonists with a dibenzosilole scaffold as a hydrophobic core structure2015
- Author(s)
  Toyama, H.; Nakamura, M.; Hashimoto, Y.; Fujii, S.*
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 23 Pages : 2982-2988
- DOI
  10.1016/j.bmc.2015.05.004
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-26293025
[Journal Article] Degradation of HaloTag-fused nuclear proteins using bestatin-HaloTag ligand hybrid molecules2015
- Author(s)
  Shusuke Tomoshige, Mikihiko Naito, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  Organic & Biomolecular Chemistry
  
  Volume : 13 Pages : 9746-9750
- DOI
  10.1039/c5ob01395j
- Open Access / Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Design and synthesis of silicon-containing fatty acid amide derivatives as novel peroxisome proliferator-activated receptor (PPAR) agonists2015
- Author(s)
  Daisuke Kajita, Masaharu Nakamura, Yotaro Matsumoto, Minoru Ishikawa, Yuichi Hashimoto and Shinya Fujii
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 25 Pages : 3350-3354
- DOI
  10.1016/j.bmcl.2015.05.045
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15J12421, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton2015
- Author(s)
  Taki Sakai, Yotaro Matsumoto, Minoru Ishikawa, Kazuyuki Sugita, Yuichi Hashimoto, Nobuhiko Wakai, Akio Kitao, Era Morishita, Chikashi Toyoshima, Tomoatsu Hayashi, Tetsu Akiyama
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 23 Pages : 328-339
- DOI
  10.1016/j.bmc.2014.11.027
- Peer Reviewed / Open Access / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22112004, KAKENHI-PROJECT-23370066, KAKENHI-PROJECT-24590136, KAKENHI-PLANNED-25104002, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Styrylphenylphthalimides as Novel Transrepression-Selective Liver X Receptor (LXR) Modulators2015
- Author(s)
  Sayaka Nomura, Kaori Endo-Umeda, Atsushi Aoyama, Makoto Makishima, Yuichi Hashimoto, Minoru Ishikawa
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume : 6 Pages : 902-907
- DOI
  10.1021/acsmedchemlett.5b00170
- Acknowledgement Compliant / Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26293025
[Journal Article] Structure&-activity relationships of oxysterol-derived pharmacological chaperones for Niemann-Pick type C1 protein2014
- Author(s)
  Ohgane, K., Karaki, F., Noguchi-Yachide, T., Dodo, K. Hashimoto, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume : 24 Pages : 3480-3485
- DOI
  10.1016/j.bmcl.2014.05.064
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationship-guided development of retinoic acid receptor-related orphan receptor gamma (RORγ)-selective inverse agonists with a phenanthridin-6(5H)-one skeleton from a liver X receptor ligand2014
- Author(s)
  Y.Nishiyama, M.Nakamura, T.Misawa, M.Nakagomi, M.Makishima, M.Ishikawa, Y.Hashimoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 22 Pages : 2799-2808
- DOI
  10.1016/j.bmc.2014.03.007
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670053
[Journal Article] Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout2014
- Author(s)
  Karaki, F., Ohgane, K., Fukuda, H., Nakamura, M., Dodo, K., Hashimoto, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 22 Pages : 3587-3609
- DOI
  10.1016/j.bmc.2014.05.022
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-25670052, KAKENHI-PROJECT-26293025
[Journal Article] Structure-activity relationships of bisphenol A analogs at estrogen receptors (ERs): discovery of an ERα-selective antagonist.2013
- Author(s)
  K. Maruyama, M. Nakamura, S. Tomoshige, K.Sugita, M.Makishima, Yuichi Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume : 23 Pages : 4031-4036
- DOI
  10.1016/j.bmcl.2013.05.067
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-24590136, KAKENHI-PROJECT-25670053
[Journal Article] タンパク質の折りたたみの異常を直すファーマコロジカルシャペロン～ニーマンピック病C 型治療薬を目指した試み～2013
- Author(s)
  大金賢司、唐木文霞、闐闐孝介、橋本祐一
- Journal Title
  
  現代化学
  
  Volume : No.512, 11月号 Pages : 48-54
- URL
  http://www.tkd-pbl.com/news/nc243.html
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Structure-activity relationship studies of Nieman-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.2013
- Author(s)
  Karaki, F. ; Ohgane, K. ; Dodo, K. ; Hashimoto, Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 21 Pages : 5297-5309
- DOI
  10.1016/j.bmc.2013.06.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-13J06522, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670052
[Journal Article] Discovery of oxysterol-derived pharmacological chaperones for NPC-1: implication for the existence of second sterol-binding site.2013
- Author(s)
  大金賢司, 唐木文霞, 〓〓孝介, 橋本祐一
- Journal Title
  
  Chemistry & Biology
  
  Volume : 20 Pages : 391-402
- DOI
  10.1016/j.chembiol.2013.02.009
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J10583, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-25670052
[Journal Article] フォールディング異常症に対する治療薬創製の可能性2012
- Author(s)
  橋本祐一
- Journal Title
  
  MEDCHEM NEWS
  
  Volume : 22 Pages : 25-28
- URL
  http://medchem.pod.ne.jp/index.php?option=com_content&view=category&id=36&Itemid=56&lang=ja
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Design, synthesis, and biological evaluation of novel trans repression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6 H-dibenz[b,e]azepin-6-one skeleton2012
- Author(s)
  Atsushi Aoyama
- Journal Title
  
  J. Med. Chem.
  
  Volume : 55 Pages : 7360-7377
- DOI
  10.1021/jm3002394
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21790107, KAKENHI-PROJECT-22249006
[Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist.2012
- Author(s)
  Y. Itoh, M. Ishikawa, R.Kitaguchi, K.Okuhira, M.Naito, Y.Hashimoto
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume : 22 Pages : 4453-4457
- DOI
  10.1016/j.bmcl.2012.04.134
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2012
- Author(s)
  Okuhira K, Ohoka N, Sai K, Nishimaki-Mogami T, Itoh Y, Ishikawa M, Hashimoto Y, Naito M
- Journal Title
  
  FEBS Lett.
  
  Volume : 585 Pages : 1147-1152
- DOI
  10.1016/j.febslet.2011.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006
[Journal Article] Design, Synthesis and Biological Evaluation of Nuclear Receptor-degradation Inducers2011
- Author(s)
  伊藤幸裕
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 19 Pages : 6768-6778
- DOI
  10.1016/j.bmc.2011.09.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J09667, KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23790125
[Journal Article] Development of target proteinselective degradation inducer for protein knockdown2011
- Author(s)
  Y. Itoh, M. Ishikawa, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 19 Pages : 3229-3241
- DOI
  10.1016/j.bmc.2011.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006
[Journal Article] フォールディング・トラフィッキング異常の修正作用を有するリガンドの創製～網膜色素変性症への応用を目指した、変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～2011
- Author(s)
  大金賢司,闐闐孝介,橋本祐一
- Journal Title
  
  薬学雑誌
  
  Volume : 131 Pages : 325-334
- URL
  https://www.jstage.jst.go.jp/browse/yakushi/131/3/_contents/-char/ja/
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenetylphenylphthalimide skeleton derived from thalidomide-related α-glucosidase inhibitors and liver X receptor antagonists2011
- Author(s)
  K.Motoshima, K.Sugita, Y.Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 21 Pages : 3041-3045
- DOI
  10.1016/j.bmcl.2011.03.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Further application of the multitemplate approach for creation of biological response modifiers : discovery of a new class of multifunctional anti-diabetic agents2011
- Author(s)
  K.Motoshima, T.Noguchi-Yachide, M.Ishikawa, Y.Hashimoto, K.Sugita
- Journal Title
  
  Heterocycles
  
  Volume : 82 Pages : 1083-1101
- DOI
  10.3987/rev-10-sr(e)7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Estrogen receptor α/β ligands derived from thalidomide2011
- Author(s)
  T.Noguchi-Yachide, K.Sugita, Y.Hashimoto
- Journal Title
  
  Heterocycles
  
  Volume : 83 Pages : 2137-2147
- DOI
  10.3987/com-11-12287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Peroxizome proliferator-activated receptor agonists with phenethylphenylpht halimide skeleton derived from thalidomide-related liver X receptor antagonists : relationship between absolute configuration and subtype selectivity2011
- Author(s)
  K.Motoshima, M.Ishikawa, Y.Hashimoto, K.Sugita
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume : 19 Pages : 3156-3172
- DOI
  10.1016/j.bmc.2011.03.065
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Fused heterocyclic amido compounds as anti-hepatitis C virus agents2011
- Author(s)
  Hiroshi Aoyama, Masahiko Nakamura
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 19 Pages : 2675-2687
- DOI
  10.1016/j.bmc.2011.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J09835, KAKENHI-PROJECT-22249006
[Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecules : design andsynthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins2010
- Author(s)
  Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
- Journal Title
  
  J. Amer. Chem. Soc
  
  Volume : 132 Pages : 5820-5826
- DOI
  10.1021/ja100691p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092
[Journal Article] Retinobenzaldehydes as propertrafficking inducers of foldingdefective P23H rhodopsin mutant responsible for Retinitis Pigmentosa2010
- Author(s)
  K.Ohgane, K.Dodo, Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem.
  
  Volume : 18 Pages : 7022-7028
- DOI
  10.1016/j.bmc.2010.08.014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Nitrogen-containing fused-heteroaromatic compounds as a anti-bovine diarrhea virus (BVDV) agents.2010
- Author(s)
  Aoyama H, Baba M, Hashimoto Y
- Journal Title
  
  Curr. Bioactive Comp. 6(2)
  
  Pages : 118-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] LXXLL peptide mimetics as inhibitors of the interaction of vitamin D receptor with coactivators.2010
- Author(s)
  Mita Y, Dodo K, Noguchi-Yachide T, Miyachi H, Makishima M, Hashimoto Y, Ishikawa M
- Journal Title
  
  Bioorg. Med. Chem. Lett. 20(5)
  
  Pages : 1712-1717
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Novel selective anti-androgens with a diphenylpentane skeleton2010
- Author(s)
  K.Maruyama, T.Noguchi-Yachide, K.Sugita, Y.Hashimoto, M.Ishikawa
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume : 20 Pages : 6661-6666
- DOI
  10.1016/j.bmcl.2010.09.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Protein knockdown using methyl bestatin-ligand hybrid molecule: design and sythesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins.2010
- Author(s)
  Itoh Y, Ishikawa M, Naito M, Hashimoto Y
- Journal Title
  
  J. Amer. Chem. Soc. 132(16)
  
  Pages : 5820-5826
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Structural development studies of anti-hepatitis virus C virus agents2010
- Author(s)
  M.Nakamura, A.Aoyama, M.T.M.Salim, M.Okamoto, M.Baba, M.Baba, H.Miyachi, Y.Hashimoto, H.Aoyama
- Journal Title
  
  Bioorg. Med. Chem
  
  Volume : 18 Pages : 2402-2411
- DOI
  10.1016/j.bmc.2010.02.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249006
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epi-gallocatechin gallate.2009
- Author(s)
  Kosuke Dodo, Taro Minato, Yuichi Hashimoto
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 57
  
  Pages : 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Discovery of tetramethyltetrahydronaphthalene analogs as adult T-cell leukemia cells-selective proliferation inhibitors in a small chemical library constructed based on multi-template hypothesis.2009
- Author(s)
  Nakamura M, Hamasaki T, Tokitou M, Baba M, Hashimoto Y, Aoyama H
- Journal Title
  
  Bioorg. Med. Chem. 17(13)
  
  Pages : 4740-4746
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to (-)-epigallocatechin gallate2009
- Author(s)
  Dodo, K., Minato, T., Hashimoto, Y.
- Journal Title
  
  Chemical and Pharmaceutical Bulletin 57(2)
  
  Pages : 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] マルチテンプレート手法によるサリドマイドの構造展開と活性拡張.2009
- Author(s)
  橋本祐一
- Journal Title
  
  和光純薬時報 77(1)
  
  Pages : 2-5
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Diphenylpentane skeleton as a multi-template for steroid skeleton-recognizing receptors/enzymes.2009
- Author(s)
  Hosoda S, Matsuda D, Tomoda H, Hashimoto Y
- Journal Title
  
  Mini-Rev. Med. Chem. 9(5)
  
  Pages : 572-580
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epi-gallocatechin gallate2009
- Author(s)
  Kosuke Dodo, Taro Minato, Yuichi Hashimoto
- Journal Title
  
  Chemical & Pharmaceutical Bulletin 57
  
  Pages : 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Enhancement of chemically-induced HL-60 cell differentiation by 3, 3'-diindolulmethane derivatives.2009
- Author(s)
  Noguchi-Yachide T, Tetsuhashi M, Aoyama H, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 57(5)
  
  Pages : 536-540
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] New tubulin-polymerization inhibitor derived from thalidomide: implication for anti-myeloma therapy.2008
- Author(s)
  Kizaki M, Hashimoto Y
- Journal Title
  
  Curr. Med. Chem. 15(8)
  
  Pages : 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] New tubulin-polymerization inhibitor derived from thalidomide:Implications for anti-myeloma therapy.2008
- Author(s)
  Masahiro Kizaki and Yuichi Hashimoto
- Journal Title
  
  Curr. Med. Chem. 15(8)
  
  Pages : 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] 4-(Anilino)pyrrole-2-carboxiamides: novel non-steroidal/non-anilide type androgen antagonisits effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor.2008
- Author(s)
  Wakabayashi K, Imai K, Miyachi H, Hashimoto Y, Tanatani A
- Journal Title
  
  Bioorg. Med. Chem. 16(14)
  
  Pages : 7046-7054
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structure-activity relationship of bis-galloyl derivatives related to(-)-epigallocatechin gallate.2008
- Author(s)
  Kosuke Dodo, Taro Minato and Yuichi Hashimoto
- Journal Title
  
  Chem. Pharm. Bull. 57(2)
  
  Pages : 190-194
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008
- Author(s)
  Hashimoto Y
- Journal Title
  
  Arch. Pharm. Life Sci. 341(9)
  
  Pages : 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Anriproliferative and apoptosis-inducing activities of alkyl gallate and gallamide derivatives related to (-)-epigallocatechin gallate.2008
- Author(s)
  Dodo K, Minato T, Noguchi-Yachide T, Suganuma M, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 16(17)
  
  Pages : 7975-7982
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] New tubulin polymerization inhibitor derived from thalidomide : Implications for anti-myeloma therapy2008
- Author(s)
  Kizaki, M. and Hashimoto, Y.
- Journal Title
  
  Current Medicianl Chemistry 15(8)
  
  Pages : 754-765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structural development of benzhydrol-type 1'-acetoxychavicol acetate (ACA) analogs as human leukemia cell-growth inhibitors based on quantitative structure-activity relationship (QSAR) analysis.2008
- Author(s)
  Misawa T, Aoyama H, Furuyama T, Dodo K, Sagawa M, Miyachi H, Kizaki M, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 56(10)
  
  Pages : 1490-1495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Co-existence of alpha-glucosidase-inhibitory activity and liver X receptor-regulatory activities and their separation by structural development.2008
- Author(s)
  Dodo K, Aoyama H, Noguchi-Yachide T, Makishima M, Miyachi H, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 16(8)
  
  Pages : 4272-4285
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008
- Author(s)
  Yuichi Hashimoto
- Journal Title
  
  Arch. Pharm. Life Sci. 341(9)
  
  Pages : 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin.2008
- Author(s)
  Sato S, Tetsuhashi M, Sekine K, Miyachi H, Naito M, Hashimoto Y, Aoyama H
- Journal Title
  
  Bioorg. Med. Chem. 16(8)
  
  Pages : 4685-4698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds.2008
- Author(s)
  Hashimoto Y
- Journal Title
  
  Arch. Pharm. Life Sci 341(9)
  
  Pages : 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Thalidomide as a multi-template for development of biologically active compounds2008
- Author(s)
  Hashimoto, Y.
- Journal Title
  
  Archives der Pharmazie, Life Science 341(9)
  
  Pages : 536-547
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Structural development studies of nuclear receptor ligands.2007
- Author(s)
  Hosoda S, Hashimoto Y
- Journal Title
  
  Pure Appl. Chem. 79(4)
  
  Pages : 615-626
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19390028
[Journal Article] Development of tubulin-polymerization inhibitors based on thalidomide skeleton.2007
- Author(s)
  Aoyama H, Noguchi T, Misawa T, Nakamura T, Miyachi H, Hashimoto Y, Kobayashi H
- Journal Title
  
  Chem. Pharm. Bull. 55(6)
  
  Pages : 844-949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] 3, 3-Diphenylpentane skeleton as a steroid substitute: novel inhibitors for human 5α-reductase 1.2007
- Author(s)
  Hosoda S, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. Lett. 17(19)
  
  Pages : 5414-5418
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Effects of immunomodulatory derivatives of thalidomide (IMiDs) and their analogs on cell-differentiation, cyclooxygenase activity and angiogenesis.2006
- Author(s)
  Fujimoto H, Noguchi T, Kobayashi H, Miyachi H, Hashimoto Y
- Journal Title
  
  Chem. Pharm. Bull. 54(6)
  
  Pages : 855-860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferators-activated receptor α/σ dual agonists.2006
- Author(s)
  J.Kasuga, M.Makishima, Y.Hashimoto, H.Miyachi
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 16・3
  
  Pages : 554-558
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helic-folding inhibition hypothesis.2005
- Author(s)
  K.Hashimoto, H.Miyauchi
- Journal Title
  
  Bioorganic & Medicinal Chemistry 13・17
  
  Pages : 5080-5093
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005
- Author(s)
  Miyachi H, Hashimoto Y
- Journal Title
  
  Bioorg. Med. Chem. 13(17)
  
  Pages : 5080-5093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17016013
[Journal Article] A new class androgen receptor antagonists bearing carborane in place of a steroidal skeleton.2005
- Author(s)
  S.Fujii, Y.Hashimoto, T.Suzuki, Ohta, Y.Endo
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters 15・1
  
  Pages : 227-230
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005
- Author(s)
  Y.Hashimoto
- Journal Title
  
  Bioorg. Med. Chem. 13・17
  
  Pages : 5080-5093
- Data Source
  KAKENHI-PROJECT-13NP0401
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis2005
- Author(s)
  Yuichi Hashimoto, et al.
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 13(17)
  
  Pages : 5080-5093
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis.2005
- Author(s)
  Yuichi Hashimoto, 他1名
- Journal Title
  
  Bioorganic ＆ Medicinal Chemistry 13・17
  
  Pages : 5080-5093
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Novel non-steroidal/non-anilide type androgen antagonists : discovery of 4-substituted pyrrole-2-carboxamides as a new scaffold for androgen receptor ligand.2005
- Author(s)
  K.Wakabayashi, H.Miyachi, Y.Hashimoto, A.Tanatani
- Journal Title
  
  Bioorganic & Medicinal Chemistry 13・8
  
  Pages : 2837-2846
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] 薬害の克服を目指した創薬化学:サリドマイドをマルチ創薬テンプレートとして活用したサリドマイドの構造展開と活性拡張2005
- Author(s)
  宮地弘幸, 橋本祐一
- Journal Title
  
  ファルマシア 41・1
  
  Pages : 33-37
- Data Source
  KAKENHI-PROJECT-15659025
[Journal Article] サリドマイドとがん治療2005
- Author(s)
  野口友美, 橋本祐一
- Journal Title
  
  がん分子標的治療 3・1
  
  Pages : 16-23
- Data Source
  KAKENHI-PROJECT-14030012
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto 他3名
- Journal Title
  
  Drugs Future 29・4
  
  Pages : 383-391
- Data Source
  KAKENHI-PROJECT-15659025
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto 他3名
- Journal Title
  
  Drugs Future 24・9
  
  Pages : 383-391
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto, 他3名
- Journal Title
  
  Drugs Future 29・4
  
  Pages : 383-391
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design2004
- Author(s)
  Yuichi Hashimoto, et al.
- Journal Title
  
  Drugs Future 29(4)
  
  Pages : 383-391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.2004
- Author(s)
  Yuichi Hashimoto 他6名
- Journal Title
  
  Drugs Future 29・4
  
  Pages : 383-391
- Data Source
  KAKENHI-PROJECT-14030012
[Journal Article] Structural development of biological response modifiers based on retinoids and thalidomide.2002
- Author(s)
  Yuichi Hashimoto
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry 2・6
  
  Pages : 543-551
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Structural development of biological response modifiers based on retinoids and thalidomide2002
- Author(s)
  Yuichi Hashimoto
- Journal Title
  
  Mini-Reviews in Medicinal Chemistry 2(6)
  
  Pages : 543-551
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14103018
[Journal Article] Thalidomide as a multi-target drug and its application as a template for drug design.
- Author(s)
  Y.Hashimoto
- Journal Title
  
  Drugs Future (印刷中)
- Data Source
  KAKENHI-PROJECT-13NP0401
[Presentation] ER downregulationの母格横断的な構造活性相関2018
- Author(s)
  南條舜、谷内出友美、吉岡広大、槇島誠、石川稔、橋本祐一、大金賢司
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ItraconazoleのNPC1シャペロンとしての構造活性相関研究2018
- Author(s)
  安藤有輝、塩井隆太、吉岡広大、谷内出友美、石川稔、橋本祐一、大金賢司
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 神経変性疾患原因タンパク質のケミカルノックダウン2017
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 神経変性疾患関連凝集タンパク質分解誘導剤の開発2017
- Author(s)
  山下博子、友重秀介、野村さやか、大金賢司、橋本祐一、石川稔
- Organizer
  日本ケミカルバイオロジー学会第12会年会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] パーフルオロアルコール基の代替官能基としてのシラノール基の医薬的有用性の検討2017
- Author(s)
  外山大純、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第12会年会
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Phenanthridin-6(5H)-one骨格を有する非ステロイド型プロゲステロン受容体拮抗薬の創製2017
- Author(s)
  西山郵子、森修一、槇島誠、藤井晋也、影近弘之、橋本祐一、石川稔
- Organizer
  日本レチノイド研究会第28会学術集会
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] ドラッグリポジショニングによるニーマンピック病Ｃ型に対するシャペロンドラッグの探索2017
- Author(s)
  (2)大金賢司、塩井隆太、安藤勇輝、谷内出友美、石川稔、どど幸介、袖岡幹子、橋本祐一
- Organizer
  第35回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PROJECT-17H03996
[Presentation] 新規アンドロゲン受容体AF-1モジュレーターの構造活性相関．2016
- Author(s)
  沼館慧剛、梅田香織、槇島誠、橋本祐一、藤井晋也
- Organizer
  日本レチノイド研究会第27回学術集会
- Place of Presentation
  昭和薬科大学（東京都町田市）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Structural and functional development of retinoids/steroids.2016
- Author(s)
  Yuichi Hashimoto
- Organizer
  International Conference for the 70th Anniversary of Pharmaceutical Society of Korea
- Place of Presentation
  The-K Hotel Seoul（韓国）
- Year and Date
  2016-10-18
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] 新規BRD4/HDAC二重阻害活性化合物の創製．2016
- Author(s)
  雨宮聖花、山口卓男、境太希、橋本祐一、谷内出友美
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 小分子による蛋白変性疾患制圧のこころみ．2016
- Author(s)
  橋本祐一
- Organizer
  創薬懇話会 2016
- Place of Presentation
  エクシブ蓼科（長野県茅野市）
- Invited
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] AF-1領域による機能制御を指向した新規アンドロゲン受容体モジュレーターの創製2016
- Author(s)
  沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] N6-ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製研究．2016
- Author(s)
  谷内出友美、橋本祐一
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  大分県別府市別府国際コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 核内受容体リガンドを指向した1,3,5-トリアジン誘導体の設計と構造展開2016
- Author(s)
  海東和麻、谷内出友美、中津亜紀、森修一、橋本祐一、影近弘之、藤井晋也
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Structural and functional development of retinoids/steroids.2016
- Author(s)
  Yuichi Hashimoto
- Organizer
  International Conference for the 70th Anniversary of Pharmaceutical Society of Korea
- Place of Presentation
  The-K Hotel Seoul（韓国）
- Year and Date
  2016-10-18
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出．2016
- Author(s)
  山口卓男、岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] ハンチントン病原因タンパク質の分解誘導薬の創製．2016
- Author(s)
  友重秀介、野村さやか、山下博子、大金賢司、橋本祐一、石川稔
- Organizer
  第34回メディシナルケミストリーシンポジウム
- Place of Presentation
  つくば国際会議場（茨城県つくば市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] アンドロゲン受容体AF-1モジュレーターの構造展開．2016
- Author(s)
  沼館慧剛、谷内出友美、梅田香織、槇島誠、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] ベンゾイルアデニン骨格を有する新規BRD4阻害剤の創製2016
- Author(s)
  雨宮聖花、境太希、橋本祐一、山口卓男、谷内出友美
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Huntingtinタンパク質を減少させるSNIPER化合物の創製2016
- Author(s)
  友重秀介、大金賢司、内藤幹彦、石川稔、橋本祐一
- Organizer
  日本薬学会第136年会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] PPARα/δデュアル転写誘導活性を有する新規ACC2阻害剤の創出．2016
- Author(s)
  吉岡広大、西山郵子、山田歩、影近弘之、橋本祐一、藤井晋也
- Organizer
  日本ケミカルバイオロジー学会第11回年会
- Place of Presentation
  京都テルサ（京都府京都市）
- Year and Date
  2016-06-15
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] 新規骨格構造を有する非ステロイド型GRリガンドの探索と構造展開．2016
- Author(s)
  吉岡広大、西山郵子、山田歩、影近弘之、橋本祐一、藤井晋也
- Organizer
  日本レチノイド研究会第27回学術集会
- Place of Presentation
  昭和薬科大学（東京都町田市）
- Year and Date
  2016-10-22
- Data Source
  KAKENHI-PROJECT-16K15137
[Presentation] Design and synthesis of novel ROR inverse agonists based on silicon-containing hetgerocyclic core structure2015
- Author(s)
  H. Toyama, M. Nakamura, Y. Hashimoto, S. Fujii
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and optimization of distinctive nuclear receptors modulators (I): Inhibitors of the interaction of VDR with coactivators, and nuclear receptors-degradation inducers2015
- Author(s)
  Minoru Ishikawa, Yusuke Mita, Yukihiro Itoh, Risa Kitaguchi, Makoto Makishima, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Transrepression作用選択的なLXRリガンドの創製2015
- Author(s)
  野村さやか、遠藤（梅田）香織、青山惇、槇島誠、橋本祐一、石川稔
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of transrepression-selective liver X receptor (LXR) ligands2015
- Author(s)
  S. Nomura, K. Endo-Umeda, A. Aoyama, M. Ishikawa, M. Makishima, Y. Hashimoto
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Novel BRD4 inhibitors with a N6-benzoyladenine skeleton2015
- Author(s)
  T. Noguchi-Yachide, T. Sakai, Y. Hashimoto, T. Yamaguchi
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Retinoids/steroids as ligands for pharmacological chaperons and protein knockdown approach2015
- Author(s)
  Yuichi Hashimoto
- Organizer
  AIMECS 2015 (10th AFMC International Medicinal Chemistry Symposium), Oct. 18-21, 2015 (Korea, ICC JELU)
- Place of Presentation
  Korea, ICC JELU
- Year and Date
  2015-10-18
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Retinoids/steroids as ligands for pharmacological chaperons and protein knockdown approach2015
- Author(s)
  Yuichi Hashimoto
- Organizer
  RICT 2015 (Rencontres Internationales de Chimie Therapeutique)
- Place of Presentation
  Avignon, France
- Year and Date
  2015-07-01
- Int'l Joint Research / Invited
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] フェナンスリジノン骨格を有するステロイドホルモン受容体リガンドの創製2015
- Author(s)
  西山郵子、藤井晋也、石川稔、橋本祐一、槇島誠
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of silicon-based biological active compounds by focusing on silyl functionality as a cis-olefin mimetic2015
- Author(s)
  D. Kajita, M. Nakamura, Y. Matsumoto, M. Ishikawa, Y. Hashimoto, S. Fujii
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 新規PPARαアゴニストの探索と構造展開、およびhACC2阻害活性評価2015
- Author(s)
  岡崎翔吾、境太希、谷内出友美、石川稔、橋本祐一、山口卓男
- Organizer
  第33回メディシナルケミストリーシンポジウム
- Place of Presentation
  幕張国際研究センター（千葉県千葉市）
- Year and Date
  2015-11-25
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Discovery and optimization of distinctive nuclear receptor modulators (II): Transrepression selective LXR ligands, and LXRβ selective agonists2015
- Author(s)
  Minoru Ishikawa, Sayaka Nomura, Atsushi Aoyama, Kaori Endo-Umeda, Kazunori Motoshima, Makoto Makishika, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Polypharmacological profiles of phenathridinone derivatives2015
- Author(s)
  Y. Nishiyama, T. Misawa, H. Aoyama, S. Fujii, M. Ishikawa, Y. Hashimoto
- Organizer
  PACIFICHEM 2015 (2015 International Chemical Congress of Pacific Basin Societies)
- Place of Presentation
  Honolulu, Hawaii (USA)
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Development of androgen receptor (AR) activation function-1 (AF-1) modulators2015
- Author(s)
  Shinya Fujii, Akiyoshi Numadate, Tomomi Noguchi-Yachide, Kaori Endo-Umeda, Makoto Makishima, and Yuichi Hashimoto
- Organizer
  The 3rd International Conference on Retinoids
- Place of Presentation
  岐阜グランドホテル（岐阜県岐阜市）
- Year and Date
  2015-10-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] マルチテンプレート手法を用いた新規TGR5 リガンドの創製研究2014
- Author(s)
  小針孝夫、三澤隆史、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] NPC1 の局在異常を修正する非ステロイド性リガンドの創製研究2014
- Author(s)
  福田寛充、大金賢司、唐木文霞、闐闐孝介、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 膠芽腫幹細胞を標的としたsirtuin2 阻害剤の創製研究2014
- Author(s)
  境太希、若井信彦、松本洋太郎、林寛敦、石川稔、杉田和幸、北尾彰朗、秋山徹、橋本祐一
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 神経変性疾患原因タンパク質分解誘導剤の創製研究2013
- Author(s)
  友重秀介、北口梨沙、大金賢司、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Retinoids as ligands for pharmaceutical chaperone and protein knockdown approach2012
- Author(s)
  Y. Hashimoto
- Organizer
  The 1st International Symposium on Latent TGF-βActivation Reaction
- Place of Presentation
  Kobe
- Year and Date
  2012-02-25
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteosomal degradation of target protein2012
- Author(s)
  M. Naito, K. Okuhira, N. Ohoka, N. Shibata, T. Hattori, Y. Itoh, M. Ishikawa, Y. Hashimoto
- Organizer
  The Sixth International Conference. SUMO, Ubiquitin, UBL Proteins
- Place of Presentation
  Houston
- Year and Date
  2012-02-08
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] PFIC2 の原因となる変位型BSEP の機能を修正する新規小分子の発見と構造展開2012
- Author(s)
  三澤隆史、林久允、杉山雄一、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] タンパク質ノックダウン法を利用した新治療戦略と低分子の標的タンパク質同定法2012
- Author(s)
  石川稔、どど孝介、伊藤幸裕、淺沼三和子、佐藤伸一、袖岡幹子、内藤幹彦、橋本祐一
- Organizer
  日本ケミカルバイオロジー学会第7回年会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] サリドマイド由来エストロゲン受容体リガンドの創製2012
- Author(s)
  谷内出友美、杉田和幸、松本洋太郎、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] NPC1 変異体のフォールディング効率低下をrescue するステロール誘導体の発見、およびNPC1 の第二のステロール結合部位の存在2012
- Author(s)
  大金賢司、唐木文霞、闐闐孝介、橋本祐一
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Retinoids as ligands for pharmaceutical chaperone and protein knockdown approach2012
- Author(s)
  Yuichi Hashimoto
- Organizer
  The 1st International Symposium on Latent TGF-β Activation Reaction
- Place of Presentation
  神戸(招待講演)
- Year and Date
  2012-02-25
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 疫調節作用選択的な肝臓X受容体(LXR)リガンドの創製2012
- Author(s)
  青山惇、梅田(遠藤)香織、岸田健治、大金賢司、谷内出(野口)友美、青山洋史、石川稔、宮地弘幸、槇島誠、橋本祐一
- Organizer
  日本レチノイド研究会第23回学術集会
- Place of Presentation
  米子
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Pharmacological chaperones and protein knockdown inducers derived from nuclear receptor ligands2012
- Author(s)
  Y.Hashimoto
- Organizer
  The 23^<rd> Symposium of Retinoids
- Place of Presentation
  Yonago
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] プロテインノックダウン法を利用した核内受容体分解誘導低分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本薬学会第131年会
- Place of Presentation
  静岡
- Year and Date
  2011-03-28
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 核内受容体を細胞内で選択的に分解誘導する分子の創製2011
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  日本レチノイド研究会第22回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein knockdown : selective degradation of target proteins in cells using methyl bestatin-ligand hybrid molecules2011
- Author(s)
  M. Ishikawa, Y. Itoh, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Organizer
  AIMECS 2011
- Place of Presentation
  Tokyo
- Year and Date
  2011-11-29
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の検討2011
- Author(s)
  奥平桂一郎、大岡伸通、最上(西巻)知子、橋本祐一、内藤幹彦
- Organizer
  日本がん分子標的治療学会第15回学術集会
- Place of Presentation
  東京
- Year and Date
  2011-06-22
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] タンパク質の形と存在状態を狙う生理活性物質の創製2011
- Author(s)
  橋本祐一
- Organizer
  平成23年度後期(秋季)有機合成化学講習会
- Place of Presentation
  東京(招待講演)
- Year and Date
  2011-11-28
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] タンパク質の形と存在状態を狙う生理活性物質の創製2011
- Author(s)
  橋本祐一
- Organizer
  平成23年度後期(秋季)有機合成化学講習会
- Place of Presentation
  東京
- Year and Date
  2011-11-17
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discovery of CRABP degradation inducers2010
- Author(s)
  Y.Itoh, M.Ishikawa, M.Naito, Y.Hashimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] プロテインノックダウン法の開発～低分子CRABP分解誘導剤の創製～2010
- Author(s)
  伊藤幸裕, 石川稔, 内藤幹彦, 橋本祐一
- Organizer
  第8回次世代の担う有機化学シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] Selective anti-androgens with a 3,3-diphenylpentane skeleton2010
- Author(s)
  K.Maruyama, M.Ishikawa, T.Noguchi-Yachide, Y.Hashimoto
- Organizer
  International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] ケミカルジェネティクスと創薬のための活性物質創製法2010
- Author(s)
  橋本祐一
- Organizer
  創薬懇話会2009
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] Protein knockdown using ubiquitination activity of cIAP1 : Discoveryof CRABP degradation inducers.2010
- Author(s)
  Y. Itoh, M. Ishikawa, M. Naito, Y. Hashimoto
- Organizer
  PACIFICHEM 2010
- Place of Presentation
  Honolulu
- Year and Date
  2010-12-15
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] ニーマンピック病C型の原因となるNPC1 変異体のフォールディング・トラフィッキング異常を修正する低分子化合物の発見と構造活性相関2010
- Author(s)
  大金賢司、闐闐孝介、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究---網膜色素変性症への応用を目指して---2010
- Author(s)
  大金賢司、どど孝介、橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] プロテインノックダウン法の開発2010
- Author(s)
  伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第8回次世代を担う有機科学シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-05-13
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] プロテインノックダウン法を利用したAR 分解誘導剤の創製2010
- Author(s)
  北口梨沙、伊藤幸裕、石川稔、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-22249006
[Presentation] Multi-template and dramatype approaches for lead generation2010
- Author(s)
  橋本祐一
- Organizer
  第3回高度医療都市を創出する未来技術国際シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] Multi-template and dramatype approaches for lead generation.2010
- Author(s)
  橋本祐一
- Organizer
  第3回高度医療都市を創出する未来技術国際シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2010-02-03
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 細胞内レチノイド結合タンパク質の分解を誘導するレチノイン酸連結化合物の創製2010
- Author(s)
  石川稔、伊藤幸裕、内藤幹彦、橋本祐一
- Organizer
  日本ビタミン学会第62回大会
- Place of Presentation
  盛岡
- Year and Date
  2010-06-11
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～網膜色素変性症への応用を目指して～2010
- Author(s)
  大金賢司, 〓〓孝介, 橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] プロテインノックダウン法を利用した創薬指向型CRABP分解誘導剤の創製2010
- Author(s)
  伊藤幸裕、石川稔、奥平桂一郎、内藤幹彦、橋本祐一
- Organizer
  第29回メディシナルケミストリーシンポジウム
- Place of Presentation
  京都
- Year and Date
  2010-11-17
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法.2010
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2010
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岡山
- Year and Date
  2010-03-29
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] フタルイミド骨格を基盤としたトリプターゼ阻害剤の創製2009
- Author(s)
  鉄橋正士、橋本祐一、青山洋史
- Organizer
  第28回メディシナルケミストリーシンポジウム
- Place of Presentation
  東京
- Year and Date
  2009-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 3,3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009
- Author(s)
  谷内出友美、鉄橋正士、青山洋史、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] マルチテンプレート手法とドラマタイプ手法に基づく生物活性物質の創製2009
- Author(s)
  橋本祐一
- Organizer
  日本化学会第3回関東支部大会
- Place of Presentation
  東京
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 変異型ロドプシンのフォールディングを促進するロドプシンリガンドの創製研究～網膜色素変性症への応用を目指して～2009
- Author(s)
  大金賢司、どど孝介、橋本祐一
- Organizer
  日本レチノイド研究会第20回学術集会
- Place of Presentation
  東京
- Year and Date
  2009-11-20
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 3, 3-diindolylmethane (DIM)誘導体におけるHL-60細胞分化促進活性2009
- Author(s)
  谷内出友美、鉄橋正士、青山洋史、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] ケミカルジェネティクスと創薬のための活性物質創製法2009
- Author(s)
  橋本祐一
- Organizer
  創薬懇話会2009
- Place of Presentation
  岐阜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] 変異型ロドプシンのフォールディングを促進する低分子化合物による網膜色素変性症治療薬創製研究2009
- Author(s)
  大金憲司、〓〓孝介、橋本祐一
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] シーズ創製のためのマルチテンプレート法とドラマタイプ法2009
- Author(s)
  橋本祐一
- Organizer
  日本薬学会第130年会
- Place of Presentation
  岐阜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21651092
[Presentation] マルチテンプレート手法とドラマタイプ手法に基づく生物活性物質の創製2009
- Author(s)
  橋本祐一
- Organizer
  日本化学会第3回関東支部大会
- Place of Presentation
  東京
- Year and Date
  2009-09-05
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] ネクローシスの分子機構解明を目指した新規細胞死誘導剤の創製2009
- Author(s)
  佐藤伸一、どど孝介、滕玉鴎、橋本祐一、袖岡幹子
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] ステロイド代替骨格として機能するジフェニルペンタン誘導体の創製---核内受容体リガンドとHMG-CoA還元酵素阻害剤---2008
- Author(s)
  細田信之介、松田大介、供田洋、橋本祐一
- Organizer
  第27回メディシナルケミストリーシンポジウム
- Place of Presentation
  大阪
- Year and Date
  2008-11-26
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] Biological response modifiers derived from thalidomide.2007
- Author(s)
  Yuichi Hashimoto
- Organizer
  The 12th Japanese Foundation for Cancer Research International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Year and Date
  2007-12-04
- Data Source
  KAKENHI-PROJECT-17016013
[Presentation] Biological response modiifiers derived from thalidomide2007
- Author(s)
  Yuichi Hashimoto
- Organizer
  The 12^th Japanese Foundation for Chncer Research International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Year and Date
  2007-12-04
- Data Source
  KAKENHI-PROJECT-19390028
[Presentation] ケイ素とcisオレフィンの可換性に着目した含ケイ素PPARアゴニストの創製
- Author(s)
  梶田大資、中村雅陽、松本洋太郎、石川稔、橋本祐一、藤井晋也
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 含ケイ素抗エストロゲン様活性物質の創製
- Author(s)
  梶田大資、中村雅陽、松本洋太郎、橋本祐一
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] ステロイド代替骨格としてのジフェニルメタン骨格～胆汁鬱滞性疾患治療薬への展開～
- Author(s)
  小針孝夫、細田信之介、貝沼雅彦、三澤隆、藤井晋也、橋本祐一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] 核内受容体選択的なCoactivator Binding Inhibitorの創製研究
- Author(s)
  福田寛充、槇島誠、石川稔、藤井晋也、橋本祐一
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] Transrepression作用選択的なスチニルフェニルフタルイミド骨格を有するLXRリガンドの創製
- Author(s)
  野村さやか、石川稔、槇島誠、青山惇、橋本祐一
- Organizer
  日本レチノイド研究会第25回学術集会
- Place of Presentation
  秋田
- Year and Date
  2014-10-11 – 2014-10-12
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第32回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293025
[Presentation] フェナンスリジノン誘導体の多重薬理学的プロファイリング
- Author(s)
  西山郵子、中村政彦、三澤隆史、青山洋史、杉田和幸、石川稔、橋本祐一、中込まどか、槇島誠、馬場昌範
- Organizer
  第32回メディシナルケミストリ－シンポジウム
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-25670052
[Presentation] LXR（Liver X Receptor）β選択的アゴニストの創製
- Author(s)
  野村さやか、石川稔、橋本祐一、梅田（遠藤）香織、槇島誠
- Organizer
  第32回メディシナルケミストリーシンポジウム講演要旨集
- Place of Presentation
  神戸
- Year and Date
  2014-11-26 – 2014-11-28
- Data Source
  KAKENHI-PROJECT-26293025

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Hashimoto Yuichi 橋本 祐一

HASHIMOTO Yuichi 橋本 祐一

橋本 裕一 ハシモト ユウイチ

橋本 祐一 ハシモト ユウイチ

Research Projects

Research Products

Co-Researchers

疾病増悪因子リガンドの構造展開と機能展開Principal InvestigatorOngoing

Principal Investigator

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ケイ素の拡張型バイオアイソスターとしての新たな展開Principal InvestigatorOngoing

Principal Investigator

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Polypharmacology based on dynamism of the target proteinPrincipal Investigator

Principal Investigator

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Chemical biology of trafficking regulation of membrane cholesterol transporter proteinPrincipal Investigator

Principal Investigator

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Chemical control of protein dramatypePrincipal Investigator

Principal Investigator

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Protein Knockdown Approach : Hybrid Small Molecules which Induce Proteasome Degradation of Target ProteinsPrincipal Investigator

Principal Investigator

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Biological response modification based on multi-template and dramatype approaches.Principal Investigator

Principal Investigator

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Thalidomide as a cell differentiation regulator

Principal Investigator

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Development of anti-tumor agents based on biological response modification.Principal Investigator

Principal Investigator

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Review Section

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サリドマイドの抗糖尿病薬への展開Principal Investigator

Principal Investigator

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がん増悪因子を阻害する医薬リードの創製Principal Investigator

Principal Investigator

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Review Section

Research Institution

Design and development of biological response modifiersPrincipal Investigator

Principal Investigator

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Research Institution

サリドマイドの構造展開による、がん増悪因子を阻害する医薬リードの創製Principal Investigator

Hashimoto Yuichi 橋本祐一

HASHIMOTO Yuichi 橋本祐一

橋本裕一ハシモトユウイチ

橋本祐一ハシモトユウイチ