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IWASAKI Shigeo
岩崎 成夫
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Alternative Names
岩崎 茂夫 イワサキ シゲオ
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Researcher Number
00013326
Affiliation (based on the past Project Information)
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1997: The Kitasato Institute, Head director, 生物機能研究所, 部長
1993 – 1996: INST.MOL.CELL.BIOSCI., UNIV.KYOTO ; PROFESSOR, 分子細胞生物学研究所, 教授
1993: 東京大学, 分子細胞生物研究所, 教授
1987 – 1992: Institute of Applied Microbiology, The University of Tokyo, 応用微生物研究所, 教授
1988: 東京大学, 応微研, 教授
Review Section/Research Field
Principal Investigator
Chemical pharmacy
Except Principal Investigator
Chemical pharmacy
/
Bioorganic chemistry
/
医薬分子機能学
Keywords
Principal Investigator
チューブリン / 有糸分裂阻害剤 / キュラシンA / ウスチロキシン / 分子認識 / 微小管機能 / チュ-ブリン / tubulin / リゾキシン / メイタンシン
…
More
/ アレナスタチンA / Rhizoxin / 有糸分裂 / 分子設計 / Maytansine部位 / 微小管機能制御物質 / Phomopsin A / 生合成 / 複合体構造 / 分子認識機構 / neurotropic / rhizoxin / molecular design / antimitotic agent / 構造活性相関 / arenastatin A / strucuture-activity / Enediyne構造 / 微生物代謝物 / 生物活性 / 抗カビ性 / 微小管 / Medicinal Resources / Effect on eucaryotic cells / キュラシン / アクチン / Endiyne構造 / 微小管タンパク活性阻害 / メイタンシン類 / 活性誘導体 / ustiloxin / VLB / A.nidulans / Dynemicin A / 向真経性 / 光アフィニティラベル / 精密構造認識 / curacin A / curacin / action mechanism / メイタンシン結合部位 / Synthetic Supply / Microbial Products / フォモプシン / molecular recognition / 新規抗がん剤 / 医薬資源 / アザコンブレタスタチン / Photoaffinity label / 抗腫瘍性 / antifungal / Bioactivity / アザコンプレタスタチン / 向真核細胞活性 / antitumor / 作用機構 / microtubules / 生理活性 / aza-combretastatin / Dolastatin 10 / maytansine site / 光アフィニティ-ラベル / β-チュブリン変異株 / Ustiloxin / 100番目アミノ酸 / 100th amino acid / MAY部位 / ustiloxins / 化学合成 / microbial products / 向神経性 / peletelet aggregation inhibition / Esperamicin / 抗腫瘍抗生物質 / 作用機作 / Natural Sources / 天然資源からの検索 / 微生物代謝産物 / 血小板凝集抑制 / 分子機能 / Calicheamicin / 分子確認
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More
Except Principal Investigator
抗腫瘍活性 / 有糸分裂阻害 / 抗ガン物質 / P-glycoprotein / ustiloxin / 海洋糸状菌 / 海綿 / 稲イモチ病菌 / 微小管重合阻害 / リゾキシン / リベロマイシン / 多剤耐性克服 / 生物活性物質 / 抗真菌 / rhizoxin / ポルフィリン / 天然物 / DRUG DEVELOPMENTAL RESEARCH / 群体ホヤ / CPT-11 / イオン輸送 / epiderstatin / leptofuranin / enamidonin / ベラパミール / 発癌プロモーター / イオンチャネル形成機構 / UK-1 / leptomycin / 多剤耐性克服機構 / ヘミン / arenastatin A / 抗癌物質 / ANTITUMOR ACTIVITY / GP120-CD4 BINDING INHIBITION / 薬剤耐性発現機構 / gp120-CD4結合阻害活性 / アポートシス / 生体機能制御 / multidrug-resistance / エポキシド基 / bidirectional regulation / 放線菌 / 2方向性調節 / カンプトテシンのヒドロキシ高級脂肪酸エステル / Epiderstatin / 紅花 / 光学異性体 / ラジンコ-ル / JS49 / MICROTUBULE ASSEMBLY INHIBITION / ホウ素含有化合物 / 腫瘍壊死因子 / カンプトテシンアシル誘導体 / 塩基選択性 / tumor promoter / 子のう菌 / 医薬品化学 / リゾキシンアシル誘導体 / ヒストンデアセチラ-ゼ阻害剤 / フタルイミド / anguinomycin / IMMUNOSUPPRESSIVE ACTIVITY / albuside A / dextran / acetophthalidin / resorcinin / 殺細胞活性 / セコスリキサイド / radicicol / 多剤耐性 / retinoid / サリドマイド / menoxymycin / 不斉合成 / 医薬品開発研究 / malolactomycin / nostodione A / チューブリンへの作用 / curacin A / di-n-buty1 malate / enantio-dependence / 免疫抑制活性 / cororubicin / O2-3D / アフィニティーラベル / cell type / P-糖蛋白質 / intercalator / ベントシアニン / 担子菌 / receptor / 微小管機能制御活性 / MDR modifier / アデノウイルス癌遺伝子 / 細胞周期特異的抗腫瘍性 / 血管新生 / 抗癌抗生物質 / biological response modifier / isojaspisin / クロモマイシン / 血管新生病 / 微生物生産物 / ホヤ / レチノイド / natural products / 細胞種 / MICROORGANISM PRODUCT / 生体機能制御活性 / antitumor / ustiloxin A / ION CHANNEL FORMATION / roseophilin / ジヌクレオチド / tumor necrosis factor / 生物学的応答調節剤 / ヒストン脱アセチル化阻害剤 / porphyrin / reveromycin / デキストラン / サイクロトリプロスタチン / tubulin / イオンチャンネル形成 / thalidomide / 抗微小管活性 / quinolidomicin / がん / gilvocarcinの化学変換 / 生物応答調節剤 / nucleic acid / カプラマイシン誘導体 / 細胞周期特異的阻害剤 / 水溶性ポリマー / gilvocarcin / チューブリン / mechanism of MDR / サイトカイン / 耐性克服物質 / affinity labeling / インターカレーション / BIOFUNCTIONAL CONTROL / スピロトリプロスタチン / 不完全菌 / エトポシド / phthalimide / lavanducyanin / trapoxin / 微生物由来薬品開発 / cytokine / MRSA / 耐性菌 / ギルボカルシンの化学変換 / ウスチロキシン / 核酸 / GP120-CD4結合阻害 / インターカレーター / 受容体 / 光学活性依存性 / 微生物代謝産物 / tryprostatin / 緑膿菌薬剤耐性阻害活性 / jaspisin / アンスラサイクリンのモルホリノ誘導体 / 抗がん物質 / 分子認識
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Research Projects
(
27
results)
Co-Researchers
(
35
People)
Project Start Year (Newest)
Project Start Year (Oldest)
微小管機能を制御する超分子形成とリガンド機能の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
微生物代謝産物リゾキシンによる血管新生阻害の機構解析とその応用
Principal Investigator
及川 勉
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
医薬分子機能学
Research Institution
Tokyo Metropolitan Organization for Medical Research
生物活性天然有機化合物の構造と機能
Principal Investigator
浪越 通夫
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Bioorganic chemistry
Research Institution
東京水産大学
STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1995
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
生物活性物質の構造と機能
Principal Investigator
浪越 通夫
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Bioorganic chemistry
Research Institution
東京水産大学
Search and development for new compounds to overcome drug resistance from natural sources
Principal Investigator
KOBAYASHI Jun'ichi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
HOKKAIDO UNIVERSITY
Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulators
Principal Investigator
HASHIMOTO Yuichi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
新規天然抗がん物質の探索
Principal Investigator
瀬戸 治男
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
DEVELOPMENTAL RESEARCH TO UTILIZE MICROORGANISM PRODUCTS HAVING POTENCY OF BIOFUNCTIONAL CONTROL FOR DRUG MATERIALS
Principal Investigator
YAMAZAKI Mikio
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
CHIBA UNIVERSITY
Preparation of Functional Polylipid Biofactors
Principal Investigator
HASHIMOTO Yuichi
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
THE UNIVERSITY OF TOKYO
新規構造を有する天然物由来抗癌物質に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1993
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
リガンド分子設計によるチューブリンの薬物認識機構の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1993
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
Regulators of Microtubule Assembly : Molecular Recognition Mechanism and Developement of New Regulators.
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Chemical pharmacy
Research Institution
Institute of Molecular and Cellular Biosciences The University of Tokyo
新規構造を有する天然物由来抗癌物質に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1992
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
有糸分裂阻害剤-チューブリン間の精密構造認識の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
新規構造を有する天然物由来抗癌物質に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1991
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Endiyne系抗腫瘍抗生物質クロモフォアの生合成の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Chemical pharmacy
Research Institution
The University of Tokyo
STUDY ON THE MICROBIAL METABOLITRES AS THE MEDICINAL RESOURCES
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Chemical pharmacy
Research Institution
THE UNIVERSITY OF TOKYO
天然物由来制癌物質の探索とその化学的誘導に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1990
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
天然物由来制癌物質の探索とその化学的誘導に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1989
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
天然物由来制癌物質の探索とその化学的誘導に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
Bio-organic Studies on Inhibition of Tubulin Assembly by Mitosis Inhibitors
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Chemical pharmacy
Research Institution
Institute of Applied Microbiology, The University of
Studies on Macrobial Metabolites Effective to Eucaryotic Cells
Principal Investigator
Principal Investigator
IWASAKI Shigeo,
奥田 重信
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Chemical pharmacy
Research Institution
The University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
HASHIMOTO Yuichi
(90164798)
# of Collaborated Projects:
9 results
# of Collaborated Products:
0 results
2.
瀬戸 治男
(10013335)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
3.
長田 裕之
(80160836)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
4.
NAGAO Yoshimitsu
(40027074)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
5.
SHIRAI Ryuichi
(80183838)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
6.
MORISAKI Naoko
(00092354)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
YAMAZAKI Mikio
(70089598)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
NOZOE Shigeo
(50013305)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
9.
別府 輝彦
(80011873)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
10.
大岳 望
(30013303)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
11.
FUJITA Tetsuro
(40027024)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
TSURUO Takashi
(00012667)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
馬替 純二
(60199643)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
吉田 稔
(80191617)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
永井 和夫
(00011974)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
浪越 通夫
(30189196)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
NAKAGAWA Akira
(60050548)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
TANAKA Haruo
(40118823)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
OHTA Tomihisa
(50108560)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
KOBAYASHI Jun'ichi
(90221241)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
YAMAMURA Shosuke
(40076708)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
FUJI Kaoru
(20027056)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
ITOKAWA Hideji
(60057304)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
NAKAMURA Shoshiro
(40013304)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
MIKAMI Yuzuru
(40092100)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
FURUKAWA Jun
(80111574)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
柿沼 勝巳
(90092543)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
内藤 幹彦
(00198011)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
小林 昭雄
(30115844)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
池上 晋
(80011980)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
及川 勉
(40120141)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
嶋村 真里子
(00124462)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
落合 正仁
(50127065)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
佐藤 良博
(20050726)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
奥田 重信
(30013296)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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