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IWASAKI Shigeo
岩崎 成夫
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Alternative Names
岩崎 茂夫 イワサキ シゲオ
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Researcher Number
00013326
Affiliation (based on the past Project Information)
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1997: The Kitasato Institute, Head director, 生物機能研究所, 部長
1993 – 1996: INST.MOL.CELL.BIOSCI., UNIV.KYOTO ; PROFESSOR, 分子細胞生物学研究所, 教授
1993: 東京大学, 分子細胞生物研究所, 教授
1987 – 1992: Institute of Applied Microbiology, The University of Tokyo, 応用微生物研究所, 教授
1988: 東京大学, 応微研, 教授
Review Section/Research Field
Principal Investigator
Chemical pharmacy
Except Principal Investigator
Chemical pharmacy
/
Bioorganic chemistry
/
医薬分子機能学
Keywords
Principal Investigator
チューブリン / 有糸分裂阻害剤 / ウスチロキシン / キュラシンA / 分子認識 / チュ-ブリン / リゾキシン / 微小管機能 / tubulin / メイタンシン
…
More
/ 有糸分裂 / Phomopsin A / Rhizoxin / Maytansine部位 / 分子認識機構 / 生合成 / 微小管機能制御物質 / 分子設計 / 複合体構造 / アレナスタチンA / 精密構造認識 / VLB / MAY部位 / Dynemicin A / 抗腫瘍抗生物質 / Endiyne構造 / Enediyne構造 / Esperamicin / Calicheamicin / Dolastatin 10 / Ustiloxin / アザコンブレタスタチン / 新規抗がん剤 / 微小管 / 医薬資源 / 微生物代謝物 / 生理活性 / 天然資源からの検索 / 活性誘導体 / 生物活性 / 作用機構 / 化学合成 / Medicinal Resources / Microbial Products / Bioactivity / Natural Sources / Synthetic Supply / 分子機能 / アザコンプレタスタチン / キュラシン / 分子確認 / フォモプシン / microtubules / molecular recognition / ustiloxin / aza-combretastatin / curacin / 作用機作 / antimitotic agent / action mechanism / molecular design / ustiloxins / curacin A / arenastatin A / 向真核細胞活性 / 微生物代謝産物 / 向神経性 / 血小板凝集抑制 / 抗腫瘍性 / 抗カビ性 / アクチン / 微小管タンパク活性阻害 / 向真経性 / Effect on eucaryotic cells / microbial products / neurotropic / peletelet aggregation inhibition / antitumor / antifungal / メイタンシン結合部位 / 100番目アミノ酸 / 光アフィニティ-ラベル / 構造活性相関 / 光アフィニティラベル / メイタンシン類 / A.nidulans / β-チュブリン変異株 / rhizoxin / maytansine site / 100th amino acid / Photoaffinity label / strucuture-activity
…
More
Except Principal Investigator
P-glycoprotein / リベロマイシン / 多剤耐性克服 / 抗ガン物質 / ustiloxin / 海洋糸状菌 / 海綿 / 生物活性物質 / 有糸分裂阻害 / 稲イモチ病菌 / リゾキシン / 微小管重合阻害 / 抗腫瘍活性 / lavanducyanin / gilvocarcin / leptomycin / 細胞周期特異的阻害剤 / rhizoxin / エトポシド / epiderstatin / ベントシアニン / カプラマイシン誘導体 / ヒストンデアセチラ-ゼ阻害剤 / リゾキシンアシル誘導体 / カンプトテシンアシル誘導体 / 多剤耐性克服機構 / 抗癌抗生物質 / セコスリキサイド / ウスチロキシン / ラジンコ-ル / ギルボカルシンの化学変換 / ホウ素含有化合物 / JS49 / ustiloxin A / reveromycin / radicicol / gilvocarcinの化学変換 / roseophilin / quinolidomicin / malolactomycin / trapoxin / ヒストン脱アセチル化阻害剤 / 抗がん物質 / resorcinin / leptofuranin / アポートシス / curacin A / スピロトリプロスタチン / サイクロトリプロスタチン / di-n-buty1 malate / アデノウイルス癌遺伝子 / チューブリンへの作用 / 抗癌物質 / anguinomycin / arenastatin A / albuside A / 紅花 / UK-1 / acetophthalidin / tryprostatin / cororubicin / menoxymycin / jaspisin / isojaspisin / nostodione A / enamidonin / 群体ホヤ / 抗真菌 / 微生物代謝産物 / 血管新生 / 血管新生病 / がん / エポキシド基 / ホヤ / 殺細胞活性 / クロモマイシン / O2-3D / 細胞周期特異的抗腫瘍性 / CPT-11 / アンスラサイクリンのモルホリノ誘導体 / カンプトテシンのヒドロキシ高級脂肪酸エステル / Epiderstatin / ベラパミール / 医薬品開発研究 / 微生物生産物 / 生体機能制御 / 免疫抑制活性 / GP120-CD4結合阻害 / イオンチャンネル形成 / 生体機能制御活性 / 微生物由来薬品開発 / 微小管機能制御活性 / gp120-CD4結合阻害活性 / 緑膿菌薬剤耐性阻害活性 / イオンチャネル形成機構 / 不斉合成 / 子のう菌 / 担子菌 / 放線菌 / 不完全菌 / 抗微小管活性 / イオン輸送 / DRUG DEVELOPMENTAL RESEARCH / MICROORGANISM PRODUCT / BIOFUNCTIONAL CONTROL / IMMUNOSUPPRESSIVE ACTIVITY / ANTITUMOR ACTIVITY / MICROTUBULE ASSEMBLY INHIBITION / GP120-CD4 BINDING INHIBITION / ION CHANNEL FORMATION / デキストラン / インターカレーター / レチノイド / ポルフィリン / アフィニティーラベル / 核酸 / 受容体 / 発癌プロモーター / 分子認識 / インターカレーション / ジヌクレオチド / 塩基選択性 / 水溶性ポリマー / ヘミン / dextran / intercalator / retinoid / porphyrin / affinity labeling / nucleic acid / receptor / tumor promoter / 天然物 / 多剤耐性 / P-糖蛋白質 / チューブリン / 薬剤耐性発現機構 / 耐性克服物質 / 耐性菌 / natural products / multidrug-resistance / antitumor / tubulin / mechanism of MDR / MDR modifier / MRSA / 腫瘍壊死因子 / フタルイミド / サイトカイン / サリドマイド / 細胞種 / 生物学的応答調節剤 / 光学活性依存性 / 2方向性調節 / 光学異性体 / 医薬品化学 / 生物応答調節剤 / tumor necrosis factor / phthalimide / cytokine / thalidomide / cell type / bidirectional regulation / enantio-dependence / biological response modifier
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Research Projects
(
27
results)
Co-Researchers
(
35
People)
Project Start Year (Newest)
Project Start Year (Oldest)
微小管機能を制御する超分子形成とリガンド機能の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
微生物代謝産物リゾキシンによる血管新生阻害の機構解析とその応用
Principal Investigator
及川 勉
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
医薬分子機能学
Research Institution
Tokyo Metropolitan Organization for Medical Research
生物活性天然有機化合物の構造と機能
Principal Investigator
浪越 通夫
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (C)
Research Field
Bioorganic chemistry
Research Institution
東京水産大学
STUDIES ON THE ANTIMITOTIC AGENTS-TUBULIN INTERACTION AND DRUG DESIGN
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
INSTITUTE OF MOLECULAR AND CELLULAR BIOSCIENCES,THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1995
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
生物活性物質の構造と機能
Principal Investigator
浪越 通夫
Project Period (FY)
1995
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Bioorganic chemistry
Research Institution
東京水産大学
Search and development for new compounds to overcome drug resistance from natural sources
Principal Investigator
KOBAYASHI Jun'ichi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
HOKKAIDO UNIVERSITY
Development of Phthalimide-type Novel Tumor Necrosis Factor (TNF) Production-regulators
Principal Investigator
HASHIMOTO Yuichi
Project Period (FY)
1995 – 1997
Research Category
Grant-in-Aid for Scientific Research (B)
Research Field
医薬分子機能学
Research Institution
THE UNIVERSITY OF TOKYO
微小管機能を制御する超分子形成とリガンド機能の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1994
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
新規天然抗がん物質の探索
Principal Investigator
瀬戸 治男
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
DEVELOPMENTAL RESEARCH TO UTILIZE MICROORGANISM PRODUCTS HAVING POTENCY OF BIOFUNCTIONAL CONTROL FOR DRUG MATERIALS
Principal Investigator
YAMAZAKI Mikio
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
CHIBA UNIVERSITY
Preparation of Functional Polylipid Biofactors
Principal Investigator
HASHIMOTO Yuichi
Project Period (FY)
1994 – 1996
Research Category
Grant-in-Aid for Scientific Research (A)
Research Field
Chemical pharmacy
Research Institution
THE UNIVERSITY OF TOKYO
新規構造を有する天然物由来抗癌物質に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1993
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
リガンド分子設計によるチューブリンの薬物認識機構の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1993
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
Regulators of Microtubule Assembly : Molecular Recognition Mechanism and Developement of New Regulators.
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1993 – 1994
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Chemical pharmacy
Research Institution
Institute of Molecular and Cellular Biosciences The University of Tokyo
新規構造を有する天然物由来抗癌物質に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1992
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
有糸分裂阻害剤-チューブリン間の精密構造認識の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1992
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
新規構造を有する天然物由来抗癌物質に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1991
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1991
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
Endiyne系抗腫瘍抗生物質クロモフォアの生合成の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1991 – 1992
Research Category
Grant-in-Aid for General Scientific Research (C)
Research Field
Chemical pharmacy
Research Institution
The University of Tokyo
STUDY ON THE MICROBIAL METABOLITRES AS THE MEDICINAL RESOURCES
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1991 – 1993
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Chemical pharmacy
Research Institution
THE UNIVERSITY OF TOKYO
天然物由来制癌物質の探索とその化学的誘導に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1990
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
有糸分裂阻害剤ーチュ-ブリン分子間の精密構造認識の解析
Principal Investigator
Principal Investigator
岩崎 成夫
Project Period (FY)
1990
Research Category
Grant-in-Aid for Scientific Research on Priority Areas
Research Institution
The University of Tokyo
天然物由来制癌物質の探索とその化学的誘導に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1989
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
天然物由来制癌物質の探索とその化学的誘導に関する研究
Principal Investigator
瀬戸 治男
Project Period (FY)
1988
Research Category
Grant-in-Aid for Cancer Research
Research Institution
The University of Tokyo
Bio-organic Studies on Inhibition of Tubulin Assembly by Mitosis Inhibitors
Principal Investigator
Principal Investigator
IWASAKI Shigeo
Project Period (FY)
1988 – 1989
Research Category
Grant-in-Aid for General Scientific Research (B)
Research Field
Chemical pharmacy
Research Institution
Institute of Applied Microbiology, The University of
Studies on Macrobial Metabolites Effective to Eucaryotic Cells
Principal Investigator
Principal Investigator
IWASAKI Shigeo,
奥田 重信
Project Period (FY)
1985 – 1987
Research Category
Grant-in-Aid for Co-operative Research (A)
Research Field
Chemical pharmacy
Research Institution
The University of Tokyo
# of Projects (Dsc)
# of Projects (Asc)
1.
HASHIMOTO Yuichi
(90164798)
# of Collaborated Projects:
9 results
# of Collaborated Products:
0 results
2.
瀬戸 治男
(10013335)
# of Collaborated Projects:
7 results
# of Collaborated Products:
0 results
3.
長田 裕之
(80160836)
# of Collaborated Projects:
6 results
# of Collaborated Products:
0 results
4.
NAGAO Yoshimitsu
(40027074)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
5.
SHIRAI Ryuichi
(80183838)
# of Collaborated Projects:
5 results
# of Collaborated Products:
0 results
6.
MORISAKI Naoko
(00092354)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
7.
YAMAZAKI Mikio
(70089598)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
8.
NOZOE Shigeo
(50013305)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
9.
別府 輝彦
(80011873)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
10.
大岳 望
(30013303)
# of Collaborated Projects:
3 results
# of Collaborated Products:
0 results
11.
FUJITA Tetsuro
(40027024)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
12.
TSURUO Takashi
(00012667)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
13.
馬替 純二
(60199643)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
14.
吉田 稔
(80191617)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
15.
永井 和夫
(00011974)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
16.
浪越 通夫
(30189196)
# of Collaborated Projects:
2 results
# of Collaborated Products:
0 results
17.
NAKAGAWA Akira
(60050548)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
18.
TANAKA Haruo
(40118823)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
19.
OHTA Tomihisa
(50108560)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
20.
KOBAYASHI Jun'ichi
(90221241)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
21.
YAMAMURA Shosuke
(40076708)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
22.
FUJI Kaoru
(20027056)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
23.
ITOKAWA Hideji
(60057304)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
24.
NAKAMURA Shoshiro
(40013304)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
25.
MIKAMI Yuzuru
(40092100)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
26.
FURUKAWA Jun
(80111574)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
27.
柿沼 勝巳
(90092543)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
28.
内藤 幹彦
(00198011)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
29.
小林 昭雄
(30115844)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
30.
池上 晋
(80011980)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
31.
及川 勉
(40120141)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
32.
嶋村 真里子
(00124462)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
33.
落合 正仁
(50127065)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
34.
佐藤 良博
(20050726)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
35.
奥田 重信
(30013296)
# of Collaborated Projects:
1 results
# of Collaborated Products:
0 results
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