NAGAI Kazuo 永井和夫

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NAGAI KAZUO 永井和夫

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Researcher Number	00011974
Other IDs
Affiliation (based on the past Project Information) *help	2001 – 2010: Chubu Univ., Fac. of Appl. Biol., Prof., 応用生物学部, 教授 2002: 中部大学, 応用生命学部, 教授 2000: Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Professor, 大学院・生命理工学研究科, 教授 1990 – 2000: 東京工業大学, 生命理工学部, 教授 1989: 東京工業大学, 工学部, 教授 1986 – 1987: TOKYO UNIVERSITY, ASSOCIATE PROFESSOR, 農学部, 助教授 1986: 東大, 農学部, 助手
Review Section/Research Field	Principal Investigator 応用微生物学・応用生物化学 / Applied biochemistry / 応用微生物学・発酵学 / 応用生物化学・栄養化学 / Science and Engineering / 発酵・醸造 Except Principal Investigator Applied biochemistry / 応用微生物学・応用生物化学 / 遺伝学 / Applied microbiology / Science and Engineering / Biological pharmacy / 応用薬理学・医療系薬学
Keywords	Principal Investigator 破骨細胞 / reveromycin A / bone resorption / osteoclast / 骨吸収 / H-NS / oriC / osteoporosis / EGCG / 骨粗鬆症 … More / デストラクシン / destruxins / アポトーシス / 大腸菌 / 骨吸収抑制剤 / リベロマイシン / cell death / メバスタチン / 細胞死 / actin ring / apoptosis / レベロマイシン / 生存 / 分化 / 骨形成 / rRNA / ams / cafA / カルシウム / mre / SopA / 細胞周期 / 染色体複製 / 微生物代謝産物 / 免疫調節 / 生理活性物質 / 細胞複製 / triphenyltin / nepodin / curcumin / ルテオリン / ケルセチン / 代謝産物 / 有機スズ化合物 / フラボノイド / 植物代謝産物 / トリフェニルスズ / ネポジン / クルクミン / リベロマイシンA / inhibition / mevastatin / 選択作用 / 酸性環境 / tRNA / タンパク質合成 / 阻害 / calcium / 活性化 / ゲラニルゲラニル化 / 骨芽細胞 / カテキン / cell fusion / compactin / 抑制剤 / destruxin E / デストラキシン / コンパクチン / Bioprobe / Vacuolar type H^+-ATPase / Cytotoxic Tcell / Osteoclast / Bone metabolism / Immunomodulator / Biologically active compound / バイオプローブ / 液胞型H^+-ATPase / 細胞傷害性T細胞 / Cytoskeltal protein / Calcium / Cell cycle / Histone-like protein / 超ラセン構造 / DNA gyrase / アルコールデヒドロゲナーゼ / 細胞骨格様蛋白質 / ヒストン様蛋白質 / F plasmid / cell division / replication / Escherichia coli / HーNS / DNAー膜複合体 / sopA / oric / Fプラスミド / 細胞分裂 / DNA-膜複合体 / 細胞表層 / 生物時計 / 複製開始 / 原核細胞 / Prodigiosin / 細胞性免疫 / 免疫抑制 / 免疫修飾物質 / 細胞幼若化 / レクチン / ストレスファイバー / Green fluorescence protein / ルシフェラーゼ / 圧力刺激 / 有機溶媒 / heat shock protein / 電圧刺激 / ストレス応答 / 細胞骨格 / リポソーム / 圧力応答 / 酸化ストレス / 電気刺激 / サイトカイン / NF-κB / アクチン結合蛋白質 / 高圧応答細胞 / 活性酸素 / marRABオペロン / 分化誘導 / 電位印加 / アクチン / 細胞モデル / 加圧応答遺伝子 / 好圧性細菌 / 桿菌形態形成 / S-benzylisothiourea / mar遺伝子 / rpoSプロモーター / 抗酸化物質 / 抗がん物質 / 生薬成分 / 複製 / グリコ-ゲン・シンタ-ゼ / グリコ-ゲン / 染色体複製開始 … More Except Principal Investigator 破骨細胞 / RANKL / プロテインホスファターゼ2C / reveromycin A / osteoporosis / bone resorption / osteoclast / 機能発現 / 骨吸収抑制剤 / 微生物代謝産物 / デストラクシン / 骨粗鬆症 / ATPase / Corynebacterium glutamicum / apoptosis / アポトーシス / PC12 / 大腸菌染色体 / 細胞・組織 / 生理活性 / 酵素 / 発生・分化 / シグナル伝達 / 破骨細胞分化因子 / プロテインホスファターゼ / ustiloxin / セントロメア / トポイソメラーゼ / SEX FACTOR / PARTITION OF DNA / PLASMID / 性決定因子 / DNAの分配 / プラスミド / osteoclasts / protein phosohatase / cells, tissues / biological activity / enzyme / development, differentiation / signal transduction / 破骨細胞分化誘導因子 / berberine / coptisine / compactin / destruxins / 骨密度 / 細胞骨格 / ベロマイシン / アルカロイド / 代謝産物 / ベロマイシンA / ベルベリン / コプチシン / コンパクチン / action mechanism / microbial metabolite / destruxin / 活性化 / 機能 / 分化 / 生存 / アポトーシツ / 作用機構 / リベロマイシン / 骨吸収 / γ -Glutamyltranspeptidase / Cell wall / Cysteine / Alanine / NADH dehydrogenase / Brevibacterium Oactofermentum / γ-グルタミルトランスフェラーゼ / 呼吸鎖 / γ-グルタミルトランスペプチターゼ / γ-グルタミルトランスペプチダーゼ / 細胞壁 / システイン / アラニン / NADH脱水素酵素 / ATP ase / environmental signal responsive cells / viability imaging / cell function analysis / single-cell / 機能評価 / 遺伝子発現制御 / イメージング技術 / ストレスシグナル応答 / 環境シグナル応答 / バイアビリティ / 環境シグナル応答細胞 / バイアビリティーイメージング / 細胞機能評価 / 単一細胞 / concanamycins / cell-differentiation / prodigiosins / nurite outgrowth (NOG) / V-ATPase / bafilomycins / デストラキシン / 突起伸展 / コンカナマイシン / 細胞分化 / プロジギオシン / 突起伸展(NOG) / プロトンポンプ / バフィロマイシン / emdin / kojou / cell cycle inhibition / Antioxdative activity / RRM activity / Yunnan Provience / cytotoxity / Antitumor activity / 雲南植物圏 / エモデイン / 虎杖 / 細胞周期阻害 / 抗酸化活性 / BRM活性 / 雲南植物園 / 細胞毒性 / 抗がん活性 / plasmid partitioning / centromere / DNA methylation / replication origin / cohesion of sister chromosomes / control of replication initiation / chromosome partitioning / chromosome segregation / ヒストン様蛋白 / 修飾環 / モーター蛋白 / プロテアーゼ / 細胞分裂 / ヒトセントロメア / 人工ミニ染色体 / 枯草菌 / ミニFプラスミドDNA / oriCDNA / 免疫蛍光顕微鏡法 / DnaA / SeqA / 複製開始 / 細胞周期 / プラスミド分配 / DNAメチレーション / 複製起点 / 姉妹染色体の対合 / 複製開始の調節 / 染色体分配 / 染色体分離 / プロティンホスファターゼ2C / enamidonin / nostodione A / isojaspisin / jaspisin / menoxymycin / cororubicin / tryprostatin / acetophthalidin / UK-1 / 紅花 / albuside A / arenastatin A / anguinomycin / 抗癌物質 / チューブリンへの作用 / アデノウイルス癌遺伝子 / di-n-buty1 malate / サイクロトリプロスタチン / スピロトリプロスタチン / curacin A / アポートシス / leptofuranin / resorcinin / 抗がん物質 / ヒストン脱アセチル化阻害剤 / trapoxin / malolactomycin / quinolidomicin / 分裂酵母 / 熱ショック転写因子 / ミニ染色体 / アルフォイドDNA / ヒト染色体 / FtsH蛋白 / MukB蛋白 Less

Regulation of osteoclastogenesis by protein phosphatase 2C
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
Supperession of Osteoclast Differentiation by Protein Phosphatase 2C
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
The studies of action mechanism and pharmacological effect of anti-resorptive compounds that target osteocasts.Principal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
A Search and their action mode of microbial bioactive compounds that inhibit osteoclastic Bone Resorption.
- Principal Investigator
  
  WOO Je Tae
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied microbiology
- Research Institution
  Chubu University
A role of protein phosphatase 2C on osteoclast differentiation and activation
- Principal Investigator
  
  OHNISHI Motoko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
Effects of Low Molecular Weight Compounds on Osteoclastic Bone Resorption in vivo and in vitro.Principal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied biochemistry
- Research Institution
  Chubu University
Studies on action mechanism of microbial metabolites that specifically inhibit osteoclastic bone resorption.
- Principal Investigator
  
  WOO Je-tae
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Chubu University
Low Molecular Weight Compounds That Regulate Bone MetabolismPrincipal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Chubu University
雲南地域の植物性抗がん剤に関する研究Principal Investigator
- Principal Investigator
  
  永井和夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Institute of Technology
環境シグナル応答細胞の創製Principal Investigator
- Principal Investigator
  
  AIZAWA Masuo, 永井和夫
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo Institute of Technology
Supervision of the Research of Single-cell Molecular Technology
- Principal Investigator
  
  MATSUOKA Hideaki
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Science and Engineering
- Research Institution
  Tokyo University of Agriculture and Technology
Molecular Understanding of the Coryne-form Bacteria and its Industrial Application
- Principal Investigator
  
  TOMTA Fusao
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  HOKKAIDO UNIVERSITY
Microbial metabolites that regulate osteoclast differentiation and functionPrincipal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tokyo Institute of Technology (TIT)
Studies of Floral Antitumor Medicines in Yunnan Province
- Principal Investigator
  
  NISHIMURA Toshio
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  応用薬理学・医療系薬学
- Research Institution
  Teikyo University
Search for cell-death inducing antitumor agents based on the anti-tumor activity of V-ATPase inhibitors
- Principal Investigator
  
  OHKUMA Shoji
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biological pharmacy
- Research Institution
  Kanazawa University
Studies on physiological functions of vacuolar type H^+-ATPase using low molecular weight probesPrincipal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  TOKYO INSTITUTE OF TECHNOLOGY
Dynamics of chromosome partition apparatus
- Principal Investigator
  
  HIRAGA Sota
- Project Period (FY)
  1996 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Institute of Molecular Embryology and Genetics, Kumamoto University
ゲノムの複製終結と分配制御
- Principal Investigator
  
  HIRAGA Sota (平賀壯太)
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
新規天然抗がん物質の探索
- Principal Investigator
  
  瀬戸治男
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新規構造を有する天然物由来抗癌物質に関する研究
- Principal Investigator
  
  瀬戸治男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Roles of protein phosphorylation, calcium ion and cytoskeltal proteins in bacterial cell cycle.Principal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・応用生物化学
- Research Institution
  Tokyo Institute of Technology
Studies on regulatory factors for bacterial cell cycle.Principal Investigator
- Principal Investigator
  
  NAGAI Kazuo
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  応用微生物学・発酵学
- Research Institution
  Tokyo Institute of Technology
大腸菌oriCおよびforC領域を含む複合体の構造と機能Principal Investigator
- Principal Investigator
  
  永井和夫
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  発酵・醸造
- Research Institution
  Tokyo Institute of Technology
大腸菌oric領域を含む複合体の構造, 形成周期性および染色体複製開始との関連性Principal Investigator
- Principal Investigator
  
  永井和夫
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
マウス免疫細胞に選択的効果を有する微生物代謝産物の単離とその作用機構の解析Principal Investigator
- Principal Investigator
  
  永井和夫
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  応用生物化学・栄養化学
- Research Institution
  The University of Tokyo
Partition Mechanism of Plasmids and the Chromosome of Escherichia coli.
- Principal Investigator
  
  HIRAGA SOTA
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  遺伝学
- Research Institution
  KUMAMOTO UNIVERSITY
  Kyoto University

All 2011 2010 2009 2008 2007 2006 2005 2004 2003

All Journal Article Patent

[Journal Article] a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo.2011
- Author(s)
  Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT
- Journal Title
  
  Eur J Pharmacol. 650(2-3)
  
  Pages: 511-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Honokiol inhibits osteoclast differentiation and function in vitro.2010
- Author(s)
  Hasegawa S, Yonezawa T, Ahn JY, Cha BY, Teruya T, Takami M, Yagasaki K, Nagai K, Woo JT
- Journal Title
  
  Biol Pharm Bull. 33(3)
  
  Pages: 487-92
- NAID
  130000248103
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Phytochemicals that stimulate osteoblastic differentiation and bone formation.2010
- Author(s)
  Woo JT , Yonezawa T, Nagai K
- Journal Title
  
  J Oral Biosci. 52(1)
  
  Pages: 15-21
- NAID
  10027105179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells.2010
- Author(s)
  Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT
- Journal Title
  
  Biol Pharm Bull. 33(10)
  
  Pages: 1733-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells.2009
- Author(s)
  Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT
- Journal Title
  
  Life Sci. 84(25-26)
  
  Pages: 908-14
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells.2009
- Author(s)
  Cha BY, Shi WL, Yonezawa T, Teruya T, Nagai K, Woo JT
- Journal Title
  
  J Pharmacol Sci. 110(1)
  
  Pages: 105-10
- NAID
  10025736841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Antiresorptive microbial compounds that inhibit osteoclast differentiation, function and survival.2008
- Author(s)
  Woo JT, Yonezawa T, Cha BY, Teruya T, Nagai K
- Journal Title
  
  J Pharmacol Sci. 106(4)
  
  Pages: 547-554
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580105
[Journal Article] Food-derived polyphenols that can prevent osteoporosis2007
- Author(s)
  Woo JT, An ZY, Hasegawa S, Nagai K
- Journal Title
  
  New Food Industry 49
  
  Pages: 24-38
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture.2007
- Author(s)
  Nakagawa H, Hasumi K, Takami M, Aida-Hyugaji S, Woo JT, Nagai K, Ishikawa T, Wachi M.
- Journal Title
  
  Biochem Pharmacol. 73
  
  Pages: 34-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.2007
- Author(s)
  Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT
- Journal Title
  
  Biochem.Biophys.Res.Commun. 355
  
  Pages: 10-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Identification of two biologically crucial hydroxyl groups of (-)epigallocatechin gallate in osteoclast culture.2007
- Author(s)
  Nakagawa H, Hasumi K, Takami M, Aida-Hyugaji S, Woo JT, Nagai K, Ishikawa T, Wachi M
- Journal Title
  
  Biochem Pharmacol. 73
  
  Pages: 34-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] 骨粗髪症予防機能性食品としての食品中のポリフェノール2007
- Author(s)
  Woo JT, An ZY, Hasegawa S, Nagai K
- Journal Title
  
  New Food Industry 49
  
  Pages: 24-38
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.2007
- Author(s)
  Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT
- Journal Title
  
  Biophys. Res. Commun. 355
  
  Pages: 10-15
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway.2007
- Author(s)
  Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT
- Journal Title
  
  Biochem Biophys Res Commun 355
  
  Pages: 10-15
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture.2007
- Author(s)
  Nakagawa H, Hasumi K, Takami M, Woo JT, Nagai K, Ishikawa T, Wachi M.
- Journal Title
  
  Biochem Pharmacol 73
  
  Pages: 34-43
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] 骨粗鬆症予防機能性食品素材としての食品中のポリフェノール2007
- Author(s)
  禹済泰, 安哉龍, 長谷川森一, 永井和夫
- Journal Title
  
  ニューフードインダストリー、New Food Industry 49(印刷中)
- NAID
  40015449069
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006
- Author(s)
  Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H
- Journal Title
  
  Eur J Pharmacol. 534
  
  Pages: 55-62
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
- Author(s)
  Woo JT, Kawatani M, Kato M, Shinki T, Stern PH, Nagai K, Osada H.
- Journal Title
  
  Proc Natl Acad Sci U S A. 13. 103
  
  Pages: 4729-4734
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Inhibitoion of osteoclast differentiation by nepodin isolated from Rumex japonicus2006
- Author(s)
  Hasegawa H, Teruya T, Yonezawa T, Cha BY, K Nagai K, Woo JT
- Journal Title
  
  J.JSMUFF 4
  
  Pages: 37-41
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Inhibition of osteoclast differentiation by nepodin isolated from Rumex Japonicus ギシギシの根に含まれる破骨細胞初期分化抑制物質の単利と精製2006
- Author(s)
  Hasegawa S, Teruya T, Yonezawa Y, Cha BY, Nagai K, Woo JT
- Journal Title
  
  J. JSMUFF 4
  
  Pages: 37-41
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006
- Author(s)
  Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H
- Journal Title
  
  Eur J Pharmacol. 534
  
  Pages: 55-62
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] ギシギシの根に含まれる破骨細胞初期分化抑制物質の単利と精製2006
- Author(s)
  Hasegawa H, Teruya T, Yonezawa T, Cha BY, K Nagai K, Woo JT
- Journal Title
  
  J. JSMUFF 4
  
  Pages: 37-41
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
- Author(s)
  Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Stern PH, Nagai K, Osada H
- Journal Title
  
  Proc Natl Acad Sci USA 103
  
  Pages: 4729-4734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006
- Author(s)
  Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H
- Journal Title
  
  Eur J Pharmacol. 53
  
  Pages: 2006-2006
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
- Author(s)
  Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K, Osada H.
- Journal Title
  
  Proc Natl Acad Sci USA. 103(12)
  
  Pages: 4729-4734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
- Author(s)
  Woo JT, Kawatani M, Kato M, Shinki T, Stern PH, Nagai K, Osada H.
- Journal Title
  
  Proc Natl Acad Sci U S A. 13. 103
  
  Pages: 4729-4734
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
- Author(s)
  Woo JT, Kawatani M, Kato M, Shinki T, Stern PH, Nagai K, Osada H.
- Journal Title
  
  Proc Natl Acad Sci USA 103
  
  Pages: 4729-4734
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006
- Author(s)
  Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H, N.Udagawa, In-Sun Lee, Motoko Ohnishi, Hiromi Hagiwara, Kazuo Nagai
- Journal Title
  
  Eur J Pharmacol. 534
  
  Pages: 55-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Curcumin inhibits the proliferation and mineralization of cultured osteoblasts.2006
- Author(s)
  Notoya M, Nishimura H, Woo JT, Nagai K, Ishihara Y, Hagiwara H.
- Journal Title
  
  Eur J Pharmacol. 534
  
  Pages: 55-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts.2006
- Author(s)
  Woo JT, Kawatani M, Kato M, Shinki T, Lee KH, Stern PH, Nagai K, Osada H (他4人)Takami M, Lee KH, Stern PH, Nagai K, Osada H
- Journal Title
  
  Proc Natl Acad Sci U S A. 13. 103
  
  Pages: 4729-4734
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Statins and geranylgeranyl transferase I inhibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005
- Author(s)
  Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai
- Journal Title
  
  Biochemical Pharmacology 69
  
  Pages: 87-95
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005
- Author(s)
  Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton
- Journal Title
  
  Biochemical Pharmacology, 69
  
  Pages: 87-95
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Statins and geranylgeranyl transferase I inhibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005
- Author(s)
  Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai
- Journal Title
  
  Biochemical Pharmacology 69
  
  Pages: 87-95
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005
- Author(s)
  Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton
- Journal Title
  
  Biochemical Pharmacology, 69
  
  Pages: 87-95
- Data Source
  KAKENHI-PROJECT-17380069
[Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclearosteoclast formation induced by RNAKL and TNF2005
- Author(s)
  J-T Woo, H.Nakagawa, A.M.Krecic, K.Nagai, A.D.Hamilton, S.M.Sebti, P.H.Stern
- Journal Title
  
  Biochemical Pharmacology 69
  
  Pages: 87-95
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005
- Author(s)
  Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton, Said M.Sebti, Paula H.Stern
- Journal Title
  
  Biochemical Pharmacology, 69
  
  Pages: 87-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclearosteoclast formation induced by RNAKL and TNF2005
- Author(s)
  J-T Woo, H.Nakagawa, A.M.Krecic, K.Nagai, A.D.Hamilton S.M.Sebti, P.H.Stern
- Journal Title
  
  Biochemical Pharmacology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Statins and geranylgeranyl transferase I inihibitor inhibit mononuclear osteoclast formation induced by RANKL and TNF.2005
- Author(s)
  Je-Tae Woo, Hiroshi Nakagawa, Annette M.Krecic, Kazuo Nagai, Andrew D.Hamilton, Said M.Sebti, Paula H.Stern
- Journal Title
  
  Biochemical Pharmacology 69
  
  Pages: 87-95
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin2004
- Author(s)
  Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 1567-1574
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts.2004
- Author(s)
  Woo, J.-T., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, L.-S., Ohnishi, M., Hagiwara, H., Nagai, K.
- Journal Title
  
  Biol. Pharm. Bull 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Suppression of osteoprotegerin expression by prostaglandin E(2) is crucially involved in lipopolysaccharide-induced osteoclast formation.2004
- Author(s)
  Suda K., Udagawa N., Sato N., Takami M., Itoh K., Woo, J.T, Takahashi N., Nagai K.
- Journal Title
  
  J.Immunol. 172
  
  Pages: 2504-2510
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin2004
- Author(s)
  Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 1567-1574
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts.2004
- Author(s)
  J-T Woo, H Nakagawa, M Notoya, T Yonezawa, M Ohnishi, K.Nagai
- Journal Title
  
  Biological Pharm.Bull 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] The calcineurin/ NFAT signaling pathway regulates osteoclastogenesis in RAW264.7 cells.2004
- Author(s)
  Hirotani H, Tuohy NA, Woo JT, Stern PH, Clipstone NA, N.Udagawa, In-Sun Lee, Motoko Ohnishi, Hiromi Hagiwara, Kazuo.Nagai
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 13984-13992
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts.2004
- Author(s)
  J -T Woo, H Nakagawa, M Notoya, T Yonezawa, M Ohnishi, K.Nagai
- Journal Title
  
  Biological Pharm.Bull. 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Suppression of osteoprotegerin expression by prostaglandin E(2) is crucially involved in lipopolysaccharide-induced osteoclast formation.2004
- Author(s)
  Suda K., Udagawa N., Sato N., Takami M., Itoh K., Woo, J.T., Takahashi N., Nagai K.
- Journal Title
  
  J.Immunol. 172
  
  Pages: 2504-2510
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (-)- epigallocatechin gallate2004
- Author(s)
  Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
- Journal Title
  
  Carcinogenesis 25
  
  Pages: 1567-1574
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts2004
- Author(s)
  Woo, J.-T., Nakagawa, H., Notoya, M., Yonezawa, T., Udagawa, N., Lee, I.-S., Ohnishi, M., Hagiwara, H., Nagai, K.
- Journal Title
  
  Biol.Pharm.Bull. 27
  
  Pages: 504-509
- NAID
  110003608794
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by(-)-epigallocatechin gallate.2004
- Author(s)
  Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
- Journal Title
  
  Carcinogenesis. 25
  
  Pages: 1567-1574
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16580065
[Journal Article] Generation of hydrogen peroxide primarily contributes to the induction of Fe(H)-dependent apoptosis in Jurkat cells by (-)-epigallocatechin gallate2004
- Author(s)
  Nakagawa H, Hasumi K, Woo JT, Nagai K, Wachi M.
- Journal Title
  
  Carcinogenesis
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Journal Article] Insulin-dependent adipogenesis in stromal ST2 cells drived from murine bone marrow.2003
- Author(s)
  J.Ding, K.Nagai, J.T.Woo
- Journal Title
  
  Biosci.Biotechnol.Biochem. 67
  
  Pages: 314-321
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15380077
[Patent] 破骨細胞分化抑制剤2008
- Inventor(s)
  大西素子、永井和夫、禹済泰、木村賢一
- Industrial Property Rights Holder
  学校法人中部大学、国立大学法人岩手大学
- Industrial Property Number
  2008-219666
- Filing Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-20580105
[Patent] 骨吸収抑制剤2008
- Inventor(s)
  大西素子, 木村賢一, 萬済泰, 永井和夫.
- Industrial Property Rights Holder
  中部大学, 岩手大学
- Industrial Property Number
  2008-219666
- Filing Date
  2008-08-28
- Data Source
  KAKENHI-PROJECT-20580105

1. WOO JaeーTae (20272693)

# of Collaborated Projects: 11 results

# of Collaborated Products: 51 results
2. OHNISHI Motoko (00312653)

# of Collaborated Projects: 7 results

# of Collaborated Products: 6 results
3. WACHI Masaaki (90192822)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. HIRAGA Sota (40027321)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. AIZAWA Masuo (00016742)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. OGURA Teru (00158825)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. NISHIMURA Akiko (20142002)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. SAKUDA Shohei (80192087)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NISHIMURA Toshio (10013327)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MINAMI Motoyasu (90340207)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 加藤潤一 (10194820)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 岡崎恒子 (10022584)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 瀬戸治男 (10013335)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. 長田裕之 (80160836)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. 岩崎成夫 (00013326)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. 姚新生

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. OHYA Yoshikazu (20183767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HORIUCHI Takashi (60108644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TSURUO Takashi (00012667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. OHKUMA Shoji (10119563)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SOMEI Masanori (20110546)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. YOKOYAMA Ken (70271377)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ARAI Kunizo (50126562)

# of Collaborated Projects: 1 results

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24. HATANAKA Yasumaru (30111181)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. OHTA Tetsuo (09671290)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MATSUOKA Hideaki (10143653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HORIKOSHI Koki (80087551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KAWATA Satoshi (30144439)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. IMACHI Ko (10010076)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. MATSUE Tomokazu (70173797)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. ANDO Joji (20159528)

# of Collaborated Projects: 1 results

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32. WATANABE Kimitsuna (00134502)

# of Collaborated Projects: 1 results

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33. TOMTA Fusao (60217536)

# of Collaborated Projects: 1 results

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34. KATSUMATA Ryoichi (60292257)

# of Collaborated Projects: 1 results

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35. MATSUSHITA Kazunobu (50107736)

# of Collaborated Projects: 1 results

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36. KUMAGAI Hidehiko (70027192)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. NAKAMORI Shigeru (00254243)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 丹羽修身 (70144318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 内藤幹彦 (00198011)

# of Collaborated Projects: 1 results

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40. 吉田稔 (80191617)

# of Collaborated Projects: 1 results

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41. 小林昭雄 (30115844)

# of Collaborated Projects: 1 results

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42. 池上晋 (80011980)

# of Collaborated Projects: 1 results

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43. 青野力三 (30126643)

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44. 宝谷紘一 (80025444)

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45. 松澤洋 (00011966)

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46. 孫啓時

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47. 邵剛

# of Collaborated Projects: 1 results

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48. 加藤千明

# of Collaborated Projects: 1 results

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49. 崔承彬

# of Collaborated Projects: 1 results

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50. CUI Cheng-bin

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. YAO Xin-sheng

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NAGAI Kazuo 永井 和夫

NAGAI KAZUO 永井 和夫

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The studies of action mechanism and pharmacological effect of anti-resorptive compounds that target osteocasts.Principal Investigator

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Effects of Low Molecular Weight Compounds on Osteoclastic Bone Resorption in vivo and in vitro.Principal Investigator

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Low Molecular Weight Compounds That Regulate Bone MetabolismPrincipal Investigator

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雲南地域の植物性抗がん剤に関する研究Principal Investigator

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環境シグナル応答細胞の創製Principal Investigator

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Microbial metabolites that regulate osteoclast differentiation and functionPrincipal Investigator

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NAGAI Kazuo 永井和夫

NAGAI KAZUO 永井和夫