• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Naito Mikihiko  内藤 幹彦

ORCIDConnect your ORCID iD *help
… Alternative Names

NAITO Mikihiko  内藤 幹彦

内藤 幹彦

Less
Researcher Number 00198011
Other IDs
Affiliation (Current) 2019: 国立医薬品食品衛生研究所, 遺伝子医薬部, 部長
Affiliation (based on the past Project Information) *help 2014 – 2019: 国立医薬品食品衛生研究所, 遺伝子医薬部, 部長
2011 – 2013: 国立医薬品食品衛生研究所, 機能生化学部, 部長
2009: National Institute of Health Sciences, 機能生化学部, 部長
2007 – 2008: The University of Tokyo, 分子細胞生物学研究所, 准教授
2005 – 2006: 東京大学, 分子細胞生物学研究所, 助教授 … More
1995 – 2003: 東京大学, 分子細胞生物学研究所, 助教授
1993 – 1995: 東京大学, 分子細胞生物学研究所, 助手
1994: 東京大学, 分子細胞生物研究所, 助手
1990 – 1993: 東京大学, 応用微生物研究所, 助手
1988: 癌研究会癌化学療法センター, 日本学術振興会, 特別研究員(がん) Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Biological pharmacy / Biological pharmacy / Complex systems
Except Principal Investigator
Biological pharmacy / Complex systems
Keywords
Principal Investigator
ユビキチン / アポトーシス / プロテアソーム / Apollon / IAP / FLIP / プロテインノックダウン / cIAP1 / SNIPER / ネクローシス … More / 核移行シグナル / サイクリン / Apoxin / タンパク質分解 / 蛋白質 / P糖タンパク / 血管内皮細胞 / 血液脳関門 / 接着タンパク / ICE / Cell fusion / Mutant / 抗癌剤 / JNK / c-Abl / アクチン / 耐性 / 脳腫瘍 / ネフローシス / 活性酸素 / 細胞死 / カスパーゼ / HtrA2 / セリンプロテアーゼ / 遺伝子増幅 / HERC2 / Pradar-Willi症候群 / HECTドメイン / ケミカルバイオロジー / サイクリンA / 細胞周期 / UBCドメイン / 細胞分裂 / アミノ酸オキシダーゼ / 蛇毒 / L-amino acid oxidase / snake venom / apoptosis / Wntシグナル / Wnt / HIF / ubiquitin / proteasome / Wnt signal / nuclear localization signal / タンパク質 / Hisタグ / ヘリカルペプチド / エストロゲン受容体 / Notch / 蛋白質分解 / ペプチド / 核内受容体 / ケミカルプロテインノックダウン / PROTAC / セレブロンモジュレーター … More
Except Principal Investigator
抗癌剤耐性 / 耐性タンパク / 耐性遺伝子 / ユビキチン / アポトーシス / モノクロ-ナル抗体 / カルシウム拮抗薬 / 癌化学療法 / 多剤耐性 / モノクローナル抗体 / ビンクリスチン / アドリアマイシン / 腫瘍・宿主条件 / 薬物送達システム / 化学塞栓療法 / メタロチオネイン / P-糖タンパク / 分子標的 / 耐性克服 / 癌転移 / 転移 / シグナル伝達 / 抗癌剤 / Pー糖タンパク / ファ-マコキネティクス / P‐糖タンパク / トポイソメラ-ゼ / ファーマコキネティクス / カルシウム拮抗剤 / quinolidomicin / ustiloxin / malolactomycin / trapoxin / ヒストン脱アセチル化阻害剤 / 抗がん物質 / resorcinin / ドラッグデリバリーシステム / ターゲティング / 遺伝子治療 / 腫瘍ワクチン / 抗癌剤感受性 / 生体防御 / s-myc遺伝子 / Fas / Fasリガンドシステム / 温度感受性変異株 / アポトーシス耐性変異株 / アポトーシス抑制因子 / 癌移転 / 翻訳反応 / ナンセンスサプレッション / サプレッサーグルタミンtRNA / UAGコドン / E-box認識転写制御因子 / ATP / チャネル / トランスポーター / 分子生物学 / 電気生理学 / 糖尿病 / 脳 / 心臓 / トランスポータ / 抗がん剤耐性 / 膜輸送体 / イオン / ポンプ / 足場非依存性増殖 / スクリーニング / U0126 / Rasがん遺伝子 / Srcがん遺伝子 / MAPキナーゼ / p7056キナーゼ / Srcチロシンキナーゼ / Ablチロシンキナーゼ / 細胞接着 / 血管新生 / RB / p21^<waf1> / がん遺伝子 / がん抑制遺伝子 / cyclin D1 / CDKインヒビター / Ets-1 / がん化シグナル / 細胞周期 / チロシンキナーゼ阻害剤 / マクロライド / がん転移 / 転写因子 / 接着 / TACC3 / SNIPER / プロテアソーム / がん / 細胞死 / IAP / ケミカルバイオロジー / ステープルペプチド / 翻訳後修飾 / タンパク質分解 Less
  • Research Projects

    (34 results)
  • Research Products

    (132 results)
  • Co-Researchers

    (67 People)
  •  New frontier for ubiquitin biology driven by chemo-technologiesOngoing

    • Principal Investigator
      佐伯 泰
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science
  •  Chemical protein knockdown technology and cell regulationPrincipal InvestigatorOngoing

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      National Institute of Health Sciences
  •  人為的ユビキチン化修飾による細胞機能の制御Principal InvestigatorOngoing

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technologyPrincipal Investigator

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Development of novel small molecules degrading microtubule-associated proteins

    • Principal Investigator
      Ohoka Nobumichi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  ケミカルバイオロジーを利用した人工的ユビキチン修飾システムの開発Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
  •  Mitosis regulation by ApollonPrincipal Investigator

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  Development of protein knockdown technology to degrade pathogenic proteinsPrincipal Investigator

    • Principal Investigator
      NAITO Mikihiko
    • Project Period (FY)
      2011 – 2012
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
      The University of Tokyo
  •  Apollonによる細胞周期制御因子のユビキチン化と細胞分裂期の制御Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Health Sciences
      The University of Tokyo
  •  細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  巨大タンパク質HERC2の機能解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Regulation of the ubiquitin-proteasome system by cellular FLIPPrincipal Investigator

    • Principal Investigator
      NAITO Mikihiko
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  Caspase非依存性細胞死の誘導剤探索とその分子機構Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  FLIPによるアポトーシス制御機構の解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  細胞がん化のシグナル伝達の解析と特異的阻害剤の探索

    • Principal Investigator
      上原 至雅
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      National Institute of Infectious Diseases
  •  細胞死の分子機構とがん化学療法への応用Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  Molecular function and biosynthesis of apoxin I, an apoptosis inducing factor derived from snake venom.Principal Investigator

    • Principal Investigator
      NAITO Mikihiko
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      Institute of Molecular and Cellular Biosciences, The University of Tokyo
  •  ATP駆動型トランスポータとチャネルの構造・機能協関

    • Principal Investigator
      植田 和光
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  アポトーシス抵抗性変異細胞株の分離と細胞死の情報伝達機構の解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  がん細胞におけるアポトーシスの誘因と機構並びにその制御に関する研究

    • Principal Investigator
      口野 嘉幸
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  がん細胞の薬剤感受性と抵抗性の分子機構とその制御

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1994 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      The University of Tokyo
  •  細胞間相互作用を介してアポトーシスを制御する接着タンパクの解析Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  がん細胞におけるアポトーシスの誘因と機構並びにその制御に関する研究

    • Principal Investigator
      口野 嘉幸
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  新規構造を有する天然物由来抗癌物質に関する研究

    • Principal Investigator
      瀬戸 治男
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The University of Tokyo
  •  腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計

    • Principal Investigator
      橋田 充
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  P糖タンパクの発現を制御する組織因子の研究Principal Investigator

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokyo
  •  腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計

    • Principal Investigator
      橋田 充
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計

    • Principal Investigator
      橋田 充
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Kyoto University
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  難治性癌の薬剤抵抗性の分子機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  制がん剤耐性機構とその克服

    • Principal Investigator
      鶴尾 隆
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Japanese Foundation For Cancer Research

All 2018 2017 2016 2015 2014 2013 2012 2011 2009 2008 2007 2005 Other

All Journal Article Presentation

  • [Journal Article] Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins2018

    • Author(s)
      K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 61 Pages: 576-582

    • DOI
      10.1021/acs.jmedchem.7b00413
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib2017

    • Author(s)
      Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      Cancer Science

      Volume: 108 Pages: 1032-1041

    • DOI
      10.1111/cas.13198
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017

    • Author(s)
      Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Pages: 4985-4988

    • DOI
      10.1016/j.bmcl.2017.10.011
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules2017

    • Author(s)
      Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
    • Journal Title

      Mol Pharmacol

      Volume: 91 Pages: 159-166

    • DOI
      10.1124/mol.116.105569
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
  • [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide2017

    • Author(s)
      T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Pages: 4478-4481

    • DOI
      10.1016/j.bmcl.2017.08.001
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters2017

    • Author(s)
      Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25(6) Pages: 1846-1851

    • DOI
      10.1016/j.bmc.2017.01.044
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26290055, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017

    • Author(s)
      Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Cancer Science

      Volume: 108 Pages: 1657-1666

    • DOI
      10.1111/cas.13284
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic IAP-dependent Protein Erasers (SNIPERs).2017

    • Author(s)
      Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      J Biol Chem.

      Volume: 292 Pages: 4556-4570

    • DOI
      10.1074/jbc.m116.768853
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
  • [Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation2017

    • Author(s)
      Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 8 Pages: 1042-1047

    • DOI
      10.1021/acsmedchemlett.7b00247
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands2017

    • Author(s)
      Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      Journal of Medicinal Chemistry

      Volume: 61 Pages: 543-575

    • DOI
      10.1021/acs.jmedchem.7b00168
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
  • [Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016

    • Author(s)
      Ohoka, N., Shibata, N., Hattori, T. & Naito, M.
    • Journal Title

      Curr Cancer Drug Targets

      Volume: 16 Pages: 136-146

    • Acknowledgement Compliant / Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Journal Article] Development of peptide-based nuclear receptors degradation inducer2016

    • Author(s)
      Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Pages: 2655-2658

    • DOI
      10.1016/j.bmcl.2016.04.013
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERalpha.2016

    • Author(s)
      K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
    • Journal Title

      Methods Mol Biol

      Volume: 1366 Pages: 549-560

    • DOI
      10.1007/978-1-4939-3127-9_42
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
  • [Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016

    • Author(s)
      Ohoka N, Shibata N, Hattori T, Naito M.
    • Journal Title

      Curr. Cancer Drug Targets.

      Volume: 16 Pages: 136-146

    • DOI
      10.2174/1568009616666151112122502
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050
  • [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand2016

    • Author(s)
      Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 26 Pages: 1865-4869

    • DOI
      10.1016/j.bmcl.2016.09.041
    • Peer Reviewed / Open Access / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
  • [Journal Article] Degradation of stop codon read-through mutant proteins via the ubiquitin-proteasome system causes hereditary disorders.2015

    • Author(s)
      Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
    • Journal Title

      J. Biol. Chem

      Volume: 290 Pages: 28428-28437

    • DOI
      10.1074/jbc.m115.670901
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25460084
  • [Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.2015

    • Author(s)
      Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 25 Pages: 5362-5366

    • DOI
      10.1016/j.bmcl.2015.09.030
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
  • [Journal Article] APOLLON Protein Promotes Early Mitotic CYCLIN A Degradation Independent of the Spindle Assembly Checkpoint.2014

    • Author(s)
      Kikuchi, R., Ohata, H., Ohoka, N., Kawabata, A., Naito, M.
    • Journal Title

      J Biol Chem

      Volume: 289 Pages: 3457-3467

    • DOI
      10.1074/jbc.m113.514430
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25460084
  • [Journal Article] Design and synthesis of a tamoxifen derivative of selective estrogen receptor down-regulator2014

    • Author(s)
      Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 87-89

    • DOI
      10.1016/j.bmcl.2013.11.078
    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
  • [Journal Article] Apollon/Bruce is upregulated by Humanin.2014

    • Author(s)
      4.Hashimoto, Y., Takeshita, Y., Naito, M., Uchino, H. and Matsuoka, M
    • Journal Title

      Molecular and Cellular Biochemistry

      Volume: 397 Pages: 147-155

    • DOI
      10.1007/s11010-014-2182-4
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-25460343
  • [Journal Article] Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.2014

    • Author(s)
      1.Ohoka, N., Nagai, K., Hattori, T., Okuhira, K., Shibata, N., Cho, N. and Naito, M
    • Journal Title

      Cell Death and Disease

      Volume: 5

    • DOI
      10.1038/cddis.2014.471
    • Peer Reviewed / Open Access / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26860049
  • [Journal Article] Development of Cell-Penetrating R7 Fragment-Conjugated Helical Peptides as Inhibitors of Estrogen Receptor-Mediated Transcription2014

    • Author(s)
      2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
    • Journal Title

      Bioconjugate Chem.

      Volume: 25 Pages: 1921-1924

    • DOI
      10.1021/bc500480e
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
  • [Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013

    • Author(s)
      Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
    • Journal Title

      Cancer Sci.

      Volume: 104 Pages: 1492-1498

    • DOI
      10.1111/cas.12272
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084
  • [Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012

    • Author(s)
      Itoh, Y., Ishikawa, M., Kitaguchi, R., Okuhira, K., Naito, M. & Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 22 Pages: 4453-4457

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012

    • Author(s)
      Demizu, Y., Okuhira, K., Motoi, H., Ohno, A., Shoda, T., Fukuhara, K., Okuda, H., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 22 Pages: 1793-1796

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.2011

    • Author(s)
      Itoh, Y., Kitaguchi, R., Ishikawa, M., Naito, M. & Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 6768-6778

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Development of target protein-selective degradation inducer for protein knockdown2011

    • Author(s)
      Itoh, Y., Ishikawa, M., Kitaguchi, R., Sato, S., Naito, M. & Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem

      Volume: 19 Pages: 3229-3241

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011

    • Author(s)
      Okuhira, K., Ohoka, N., Sai, K., Nishimaki-Mogami, T., Itoh, Y., Ishikawa, M., Hashimoto, Y. & Naito, M.
    • Journal Title

      FEBS Lett

      Volume: 585 Pages: 1147-1152

    • Data Source
      KAKENHI-PROJECT-23659048
  • [Journal Article] Impairment of the ubiquitin-proteasome system by cellular FLIP.2007

    • Author(s)
      Ishioka, T., Katayama, R., Kikuchi, R., Nishimoto, M., Takada, S., Takada, R., Matsuzawa, S.I., Reed, J.C., Tsuruo, T., Naito, M.
    • Journal Title

      Genes Cells 12

      Pages: 735-744

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.2005

    • Author(s)
      Dohgu, S., Takata, F., Yamauchi, A., Nakagawa, S., Egawa, T., Naito, M., Tsuruo, T., Sawada, Y., Niwa, M., Kataoka, Y.
    • Journal Title

      Brain Res 1038

      Pages: 208-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] Cell differentiation inducers derived from thalidomide.2005

    • Author(s)
      Noguchi, T., Miyachi, H., Katayama, R., Naito, M., Hashimoto, Y.
    • Journal Title

      Bioorg Med Chem Lett 15

      Pages: 3212-5

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.2005

    • Author(s)
      Sekine, K., Hao, Y., Suzuki, Y., Takahashi, R., Tsuruo, T., Naito, M.
    • Journal Title

      Biochem Biophys Res Commun 330

      Pages: 279-85

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Journal Article] Functional characterization of adenosine transport across the BBB in mice.2005

    • Author(s)
      Murakami, H., Ohkura, A., Takanaga, H., Matsuo, H., Koyabu, N., Naito, M., Tsuruo, T., Ohtani, H., Sawada, Y.
    • Journal Title

      Int J Pharm 290

      Pages: 37-44

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-17390017
  • [Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2018

    • Author(s)
      内藤幹彦、大岡伸通、柴田識人、服部隆行
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2018

    • Author(s)
      Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2018

    • Author(s)
      Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析2017

    • Author(s)
      築茂由則、鈴木孝昌、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017

    • Author(s)
      柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2017

    • Author(s)
      内藤幹彦、大岡伸通、柴田識人、服部隆行
    • Organizer
      日本薬学会第138年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017

    • Author(s)
      大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第21回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017

    • Author(s)
      Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      EMBO conference Ubiquitin and SUMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析2017

    • Author(s)
      築茂由則、鈴木孝昌、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017

    • Author(s)
      沖津航陽,服部隆行,出水庸介,三澤隆史,正田卓司,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製2017

    • Author(s)
      鈴木孝昌、築茂由則、内藤幹彦、小原有弘
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      EMBO conference Ubiquitin and SUMO
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製2017

    • Author(s)
      鈴木孝昌、築茂由則、内藤幹彦、小原有弘
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito
    • Organizer
      2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017

    • Author(s)
      大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第21回日本がん分子標的治療学会 学術集会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases2017

    • Author(s)
      Mikihiko Naito
    • Organizer
      2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017

    • Author(s)
      Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017

    • Author(s)
      柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017

    • Author(s)
      Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017

    • Author(s)
      大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2017

    • Author(s)
      Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017

    • Author(s)
      Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通, 奥平桂一郎, 服部隆行, 内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会
    • Place of Presentation
      大分
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016

    • Author(s)
      Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases2016

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 21th 国際化学療法シンポジウム
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2016-12-14
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機構の制御と創薬への応用2016

    • Author(s)
      大岡伸通, 奥平桂一郎, 永井克典, 伊東昌宏, 柴田識人, 服部隆行, 宇治川治, 佐野修, 小山亮吉, 今枝泰宏, 奈良洋, 長展生, 内藤幹彦
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016

    • Author(s)
      Naito M, Hattori T, Ohoka N, Shibata N, Shoda T, Demizu Y, Kurihara M
    • Organizer
      第10回日米がん合同会議
    • Place of Presentation
      ラハイナ
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016

    • Author(s)
      服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
    • Organizer
      第89回日本生化学会大会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-25
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機能の制御と創薬への利用2016

    • Author(s)
      大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      横浜国際会議場(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016

    • Author(s)
      大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016

    • Author(s)
      大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016

    • Author(s)
      大岡伸通, 伊東昌宏, 奥平桂一郎, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立2016

    • Author(s)
      中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] エストロゲン受容体分解誘導剤の分子デザイン2016

    • Author(s)
      正田卓司,奥平桂一郎,内藤幹彦,栗原正明
    • Organizer
      第20回日本がん分子標的治療学会学術集会
    • Place of Presentation
      別府コンベンションセンター(大分県別府市)
    • Year and Date
      2016-05-30
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases2016

    • Author(s)
      Mikihiko Naito
    • Organizer
      The 21th 国際化学療法シンポジウム
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2016-12-14
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-16K15121
  • [Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規標的タンパク質分解誘導剤の開発2016

    • Author(s)
      藤里卓磨、正田卓司、大岡伸通、井上英史、内藤幹彦、栗原正明
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京)
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] 細胞内His タグタンパク質分解誘導剤の開発2016

    • Author(s)
      沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
    • Organizer
      第60回日本薬学会関東支部大会
    • Place of Presentation
      東京大学(東京)
    • Data Source
      KAKENHI-PROJECT-16H05090
  • [Presentation] ユビキチン化誘導剤によるユビキチン関連死の解明2015

    • Author(s)
      大岡伸通, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] Protein knockdown by SNIPER compounds, inducers for target protein-selective degradation2015

    • Author(s)
      Naito M
    • Organizer
      The 20th 国際化学療法シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-12-09
    • Int'l Joint Research / Invited
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Ubiquitin-related cancer cell death induced by small molecules degrading TACC3 protein.2015

    • Author(s)
      大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] Degradation of C-terminally extended proteins by stop codon read-through mutations cause hereditary disorders2015

    • Author(s)
      Shibata N, Ohoka N, Gondo Y, Naito M
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-10-08
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015

    • Author(s)
      大岡伸通, 服部隆行, 内藤幹彦
    • Organizer
      第19回日本がん分子標的治療学会学術集会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015

    • Author(s)
      大岡伸通、柴田識人、服部隆行、内藤幹彦
    • Organizer
      第19回日本がん分子標的治療学会 学術集会
    • Place of Presentation
      松山
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells.2014

    • Author(s)
      Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      Bigsky
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014

    • Author(s)
      Ohoka N, Ohata H, Naito M.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      Bigsky
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] エストロゲン受容体分解誘導剤による乳癌の細胞死誘導分子機構2014

    • Author(s)
      奥平 桂一郎,出水 庸介,服部 隆行,大岡 伸通,柴田 識人,最上(西巻) 知子,栗原 正明,奥田 晴宏,内藤 幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014

    • Author(s)
      Ohoka N, Ohata H, Naito M.
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      Bigsky
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation followed by rapid cell death in breast cancer cells2013

    • Author(s)
      Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
    • Organizer
      Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research
    • Place of Presentation
      ラハイナ市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン効果の検討2013

    • Author(s)
      奥平 桂一郎,大岡 伸通,最上(西巻) 知子,伊藤 幸裕,石川 稔,橋本 祐一,内藤 幹彦
    • Organizer
      第17回日本がん分子標的治療学会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013

    • Author(s)
      Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami, T, Okuda H, Kurihara M, Naito M.
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Boston
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の評価2013

    • Author(s)
      奥平桂一郎,大岡伸通,最上(西巻)知子,伊藤幸裕,石川稔,橋本祐一,内藤幹彦
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013

    • Author(s)
      大岡 伸通,大畑 広和,内藤 幹彦
    • Organizer
      第72回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] 乳癌におけるエストロゲンレセプターの分解を誘導する分子SNIPER(ER)の開発2012

    • Author(s)
      奥平桂一郎, 出水庸介, 大岡伸通, 柴田識人, 服部隆行, 最上(西巻)知子, 奥田晴宏, 栗原正明, 内藤幹彦
    • Organizer
      第16回日本がん分子標的治療学会
    • Place of Presentation
      北九州市
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins2012

    • Author(s)
      Naito, M., Okuhira, K., Ohoka, N., Shibata, N., Hattori, T., Itoh, Y., Ishikawa, M., Hashimoto, Y.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      ヒューストン市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Degradation of estrogen receptor induced by a small hybrid molecule SNIPER(ER)2012

    • Author(s)
      奥平桂一郎、出水庸介、大岡伸通、柴田識人、服部隆行、最上(西巻)知子、栗原正明、奥田晴宏、内藤幹彦
    • Organizer
      The 16th JFCR-ISCC
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] プロテインノックダウン法によるエストロゲンレセプターの分解2012

    • Author(s)
      奥平 桂一郎, 出水 庸介, 大岡 伸通, 柴田 識人, 服部 隆行, 最上(西巻) 知子, 栗原 正明, 奥田 晴宏, 内藤 幹彦
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation2012

    • Author(s)
      Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      Houston
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner2012

    • Author(s)
      Naito, M., Okuhira, K., Demizu, Y., Itoh, Y., Ishikawa, M., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Hashimoto, Y.
    • Organizer
      Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
    • Place of Presentation
      ボストン市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] プロテインノックダウン法を利用したエストロゲン受容体分解誘導剤の開発2012

    • Author(s)
      元井 宏美, 出水 庸介, 佐藤 由紀子, 奥平 桂一郎, 内藤 幹彦, 栗原 正明
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] M.:Development of SNIPER(ER) that induces estrogen receptor degradation2012

    • Author(s)
      Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      ヒューストン市、米国
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner2012

    • Author(s)
      内藤幹彦
    • Organizer
      Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
    • Place of Presentation
      Boston, USA
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins2012

    • Author(s)
      Naito, M., Okuhira, K., Ohoka, N., Shibata, N., Hattori, T., Itoh, Y., Ishikawa, M., Hashimoto, Y.
    • Organizer
      The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
    • Place of Presentation
      Houston
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Design and Synthesis of ER Degradation Inducer for Protein Knockdown Strategy2011

    • Author(s)
      Yosuke Demizu, Hiromi Motoi, Keiichiro Okuhira, Kiyoshi Fukuhara, Haruhiro Okuda, Mikihiko Naito, and Masaaki Kurihara
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Protein Knockdown: Selective Degradation of Target Proteins in Cells Using Methyl Bestatin-ligand Hybrid Molecules2011

    • Author(s)
      Minoru Ishikawa, Yukihiro Itoh, Risa Kitaguchi, Shinichi Sato, Mikihiko Naito, and Yuichi Hashimoto
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] 抗がん剤、がん分子標的治療薬の作用機序と薬剤耐性の分子機構2011

    • Author(s)
      内藤幹彦
    • Organizer
      第55回日本薬学会関東支部大会(招待講演)
    • Place of Presentation
      船橋
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] プロテインノックダウン法によるエストロゲン受容体の分解2011

    • Author(s)
      奥平桂一郎、出水庸介、大岡伸通、柴田識人、服部隆行、最上(西巻)知子、栗原正明、奥田晴宏、内藤幹彦
    • Organizer
      第70回日本癌学会学術総会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の検討2011

    • Author(s)
      奥平桂一郎、大岡伸通、最上(西巻)知子、伊藤幸裕、石川稔、橋本祐一、内藤幹彦
    • Organizer
      第15回日本がん分子標的治療学会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23659048
  • [Presentation] Regulation of Cell Death and Cell Cycle by IAPs2009

    • Author(s)
      内藤幹彦
    • Organizer
      第14回分生研シンポジウム
    • Place of Presentation
      東京大学安田講堂
    • Year and Date
      2009-10-28
    • Data Source
      KAKENHI-PROJECT-20058008
  • [Presentation] Drug resistance and apoptosis of cancer cells2009

    • Author(s)
      内藤幹彦
    • Organizer
      The 14th JFCR lnternational Symposium on Cancer Chemotherapy
    • Place of Presentation
      日航ホテル(東京)
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20015012
  • [Presentation] Small molecules destabilize cIAP1 by activating auto-ubinuitylation2008

    • Author(s)
      Naito M, et.al.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20015012
  • [Presentation] Small molecules destabilize cIAP1 by activating auto-ubiquitylation2008

    • Author(s)
      Naito M, et.al.
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca, Italy
    • Year and Date
      2008-07-10
    • Data Source
      KAKENHI-PROJECT-20058008
  • [Presentation] Molecular function of IAPs and its implication in cancer.2007

    • Author(s)
      内藤幹彦
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18659017
  • [Presentation] Molecular function of IAPs and its implication in cancer.2007

    • Author(s)
      内藤幹彦
    • Organizer
      第66回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-18015009
  • [Presentation] Protein Knockdown: Targeted Destruction of Pathogenic Proteins by SNIPER Compounds

    • Author(s)
      M. Naito
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導.

    • Author(s)
      大岡伸通, 奥平桂一郎, 柴田識人, 服部隆行, 内藤幹彦
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価

    • Author(s)
      大岡伸通、永井克典、服部隆行、奥平桂一郎、柴田識人、長展生、内藤幹彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導.

    • Author(s)
      大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価.

    • Author(s)
      大岡伸通, 永井克典, 服部隆行,奥平桂一郎, 柴田識人,長展生, 内藤幹彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.

    • Author(s)
      Nobumichi Ohoka, Katsunori Nagai, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
    • Organizer
      26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-11-18 – 2014-11-21
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導

    • Author(s)
      大岡伸通,永井克典,奥平桂一郎,柴田識人,服部隆行,長展生,内藤幹彦
    • Organizer
      第37回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] 終止コドンのリードスルー変異によるユビキチン-プロテアソーム系を介した蛋白質の不安定化

    • Author(s)
      柴田 識人,大岡 伸通,権藤 洋一,内藤 幹彦
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.

    • Author(s)
      大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
    • Organizer
      26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2014-11-18 – 2014-11-21
    • Data Source
      KAKENHI-PROJECT-26860049
  • [Presentation] SNIPER: Inducing protein degradation via recruitment to IAP

    • Author(s)
      M. Naito
    • Organizer
      248th ACS National Meeting and Exposition
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2014-08-10 – 2014-08-14
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する

    • Author(s)
      大岡 伸通,内藤 幹彦
    • Organizer
      日本がん分子標的治療学会第18回学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2014-06-25 – 2014-06-27
    • Data Source
      KAKENHI-PROJECT-25460084
  • [Presentation] Destabilization of carboxy-terminally extended proteins encoded by stop codon read-through mutation via ubiquitin-proteasome system

    • Author(s)
      柴田 識人,大岡 伸通,櫻庭 喜行,権藤 洋一,内藤 幹彦
    • Organizer
      Symposium for young ubiquitin researchers in Japan“New Era in the Ubiquitin Research”
    • Place of Presentation
      京都
    • Year and Date
      2014-11-11 – 2014-11-12
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • [Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導

    • Author(s)
      大岡伸通,奥平桂一郎,柴田識人,服部隆行,内藤幹彦
    • Organizer
      第73回日本癌学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Data Source
      KAKENHI-PUBLICLY-25112521
  • 1.  鶴尾 隆 (00012667)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 2.  杉本 芳一 (10179161)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  DEMIZU Yosuke (90389180)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 13 results
  • 4.  八巻 寛 (30013329)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  橋田 充 (20135594)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 6.  谷川 允彦 (00111956)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  西條 長宏 (00215526)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  加藤 哲郎 (40004642)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  Ohoka Nobumichi (80568519)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 40 results
  • 10.  田代 田鶴子 (50085635)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  冨田 章弘 (40251483)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  中島 元夫 (90240738)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  遊佐 敬介 (30200869)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  口野 嘉幸 (60124418)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  須田 貴司 (70250090)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  高橋 秀史 (40231394)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  田代 田鶴子 (20085608)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  永沼 章 (80155952)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  瀬戸 治男 (10013335)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  吉田 稔 (80191617)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  長田 裕之 (80160836)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  永井 和夫 (00011974)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  岩崎 成夫 (00013326)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  林 直之 (50253456)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  仙道 富士郎 (80091833)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  藤田 直也 (20280951)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  清宮 啓之 (50280623)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  馬島 哲夫 (30311228)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  小田 鈎一郎 (40012736)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  田沼 靖一 (10142449)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  植田 和光 (10151789)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  竹口 紀晃 (00019126)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  堀江 稔 (90183938)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  倉智 嘉久 (30142011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  赤池 紀生 (30040182)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  秋山 伸一 (60117413)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  鈴木 裕一 (50091707)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  上原 至雅 (50160213)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  深澤 秀輔 (10218878)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  野瀬 清 (70012747)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  早川 洋一 (20208606)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  井本 正哉 (60213253)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  沖 俊一 (40264676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  小宮山 寛機 (00106676)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  済木 育夫 (80133776)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  濱田 洋文 (00189614)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  服部 隆行 (50377751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 29 results
  • 48.  佐伯 泰 (80462779)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  村田 茂穂 (20344070)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  岩井 一宏 (60252459)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  深井 周也 (10361792)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 52.  岡本 晃充 (60314233)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 53.  伊藤 拓水 (30533179)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 54.  石川 稔 (70526839)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 55.  SYODA Takuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 56.  DEMIZU Yusuke
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 57.  KITTAKA Atsushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 58.  NOGUCHI Tomomi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 59.  MISAWA Takashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 60.  柴田 識人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 61.  権藤 洋一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 62.  栗原 正明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 63.  奥平 桂一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 64.  伊東 進
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 65.  斎藤 博幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 66.  松岡 正明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 67.  橋本 祐一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to connect your ORCID iD to this researcher?
* This action can be performed only by the researcher themselves.

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi