Naito Mikihiko 内藤幹彦

… Alternative Names

Researcher Number	00198011
Other IDs
Affiliation (Current)	2021: 東京大学, 大学院薬学系研究科(薬学部), 特任教授
Affiliation (based on the past Project Information) *help	2020 – 2021: 東京大学, 大学院薬学系研究科(薬学部), 特任教授 2020: 国立医薬品食品衛生研究所, 有機化学部, 主任研究官 2014 – 2019: 国立医薬品食品衛生研究所, 遺伝子医薬部, 部長 2011 – 2013: 国立医薬品食品衛生研究所, 機能生化学部, 部長 2009: National Institute of Health Sciences, 機能生化学部, 部長 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Biological pharmacy / Biological pharmacy / Complex systems / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Biological pharmacy / Complex systems
Keywords	Principal Investigator ユビキチン / アポトーシス / プロテアソーム / IAP / Apollon / FLIP / プロテインノックダウン / SNIPER / cIAP1 / ネクローシス … More Except Principal Investigator 抗癌剤耐性 / 耐性タンパク / 耐性遺伝子 / ユビキチン / アポトーシス / モノクロ-ナル抗体 / カルシウム拮抗薬 / 癌化学療法 / 多剤耐性 / モノクローナル抗体 / ビンクリスチン / アドリアマイシン / 腫瘍・宿主条件 / 薬物送達システム / 化学塞栓療法 / メタロチオネイン / P-糖タンパク / 分子標的 / 耐性克服 / 癌転移 / 転移 / シグナル伝達 / 抗癌剤 / Pー糖タンパク / ファ-マコキネティクス / P‐糖タンパク / トポイソメラ-ゼ / ファーマコキネティクス / カルシウム拮抗剤 / quinolidomicin / ustiloxin / malolactomycin / trapoxin / ヒストン脱アセチル化阻害剤 / 抗がん物質 / resorcinin / ドラッグデリバリーシステム / ターゲティング / 遺伝子治療 / 腫瘍ワクチン / 抗癌剤感受性 / 生体防御 / s-myc遺伝子 / Fas / Fasリガンドシステム / 温度感受性変異株 / アポトーシス耐性変異株 / アポトーシス抑制因子 / 癌移転 / 翻訳反応 / ナンセンスサプレッション / サプレッサーグルタミンtRNA / UAGコドン / E-box認識転写制御因子 / ATP / チャネル / トランスポーター / 分子生物学 / 電気生理学 / 糖尿病 / 脳 / 心臓 / トランスポータ / 抗がん剤耐性 / 膜輸送体 / イオン / ポンプ / 足場非依存性増殖 / スクリーニング / U0126 / Rasがん遺伝子 / Srcがん遺伝子 / MAPキナーゼ / p7056キナーゼ / Srcチロシンキナーゼ / Ablチロシンキナーゼ / 細胞接着 / 血管新生 / RB / p21^<waf1> / がん遺伝子 / がん抑制遺伝子 / cyclin D1 / CDKインヒビター / Ets-1 / がん化シグナル / 細胞周期 / チロシンキナーゼ阻害剤 / マクロライド / がん転移 / 転写因子 / 接着 / TACC3 / SNIPER / プロテアソーム / がん / 細胞死 / IAP / ケミカルバイオロジー / ステープルペプチド / 翻訳後修飾 / タンパク質分解 Less

がん特異的融合タンパク質の分解を阻害する脱ユビキチン化酵素と分子標的治療Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  The University of Tokyo
New frontier for ubiquitin biology driven by chemo-technologies
- Principal Investigator
  
  佐伯泰
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Chemical protein knockdown technology and cell regulationPrincipal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
  National Institute of Health Sciences
Manipulation of cellular function by forced ubiquitylationPrincipal Investigator
- Principal Investigator
  
  NAITO MIKIHIKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technologyPrincipal Investigator
- Principal Investigator
  
  Naito Mikihiko
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Development of novel small molecules degrading microtubule-associated proteins
- Principal Investigator
  
  Ohoka Nobumichi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
ケミカルバイオロジーを利用した人工的ユビキチン修飾システムの開発Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Health Sciences
Mitosis regulation by ApollonPrincipal Investigator
- Principal Investigator
  
  Naito Mikihiko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Development of protein knockdown technology to degrade pathogenic proteinsPrincipal Investigator
- Principal Investigator
  
  NAITO Mikihiko
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Health Sciences
  The University of Tokyo
Apollonによる細胞周期制御因子のユビキチン化と細胞分裂期の制御Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  National Institute of Health Sciences
  The University of Tokyo
細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
巨大タンパク質HERC2の機能解析Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Regulation of the ubiquitin-proteasome system by cellular FLIPPrincipal Investigator
- Principal Investigator
  
  NAITO Mikihiko
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
Caspase非依存性細胞死の誘導剤探索とその分子機構Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2001 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
FLIPによるアポトーシス制御機構の解析Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
細胞がん化のシグナル伝達の解析と特異的阻害剤の探索
- Principal Investigator
  
  上原至雅
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  National Institute of Infectious Diseases
細胞死の分子機構とがん化学療法への応用Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
Molecular function and biosynthesis of apoxin I, an apoptosis inducing factor derived from snake venom.Principal Investigator
- Principal Investigator
  
  NAITO Mikihiko
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Institute of Molecular and Cellular Biosciences, The University of Tokyo
ATP駆動型トランスポータとチャネルの構造・機能協関
- Principal Investigator
  
  植田和光
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
アポトーシス抵抗性変異細胞株の分離と細胞死の情報伝達機構の解析Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
がん細胞におけるアポトーシスの誘因と機構並びにその制御に関する研究
- Principal Investigator
  
  口野嘉幸
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
がん細胞の薬剤感受性と抵抗性の分子機構とその制御
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1994 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokyo
細胞間相互作用を介してアポトーシスを制御する接着タンパクの解析Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
がん細胞におけるアポトーシスの誘因と機構並びにその制御に関する研究
- Principal Investigator
  
  口野嘉幸
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
新規構造を有する天然物由来抗癌物質に関する研究
- Principal Investigator
  
  瀬戸治男
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
P糖タンパクの発現を制御する組織因子の研究Principal Investigator
- Principal Investigator
  
  内藤幹彦
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  The University of Tokyo
腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
腫瘍・宿主条件の系統的解析に基づく癌化学療法の最適化設計
- Principal Investigator
  
  橋田充
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyoto University
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
難治性癌の薬剤抵抗性の分子機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
制がん剤耐性機構とその克服
- Principal Investigator
  
  鶴尾隆
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Japanese Foundation For Cancer Research

[Book] 実験医学2020年9月号2020
- Author(s)
  内藤　幹彦
- Total Pages
  147
- Publisher
  羊土社
- ISBN
  9784758125352
- Data Source
  KAKENHI-PLANNED-18H05502
[Book] "Chapter 16， Protein degradation inducers SNIPERs and PROTACs against oncogenic proteins, In Pharmaceutical Biocatalysis Fundamentals, Enzyme Inhibitors, and Enzymes in Health and Diseases"2019
- Author(s)
  Shibata N, Ohoka N, Hattori T, Naito M.
- Total Pages
  20
- Publisher
  Jenny Stanford Publishing
- ISBN
  9789814800617
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] TRIP12 promotes small molecule-induced degradation of BRD4 through K29/K48 branched ubiquitin chains.2021
- Author(s)
  Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
- Journal Title
  
  Mol Cell
  
  Volume: 81
- DOI
  10.1016/j.molcel.2021.01.023
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997
[Journal Article] ハイブリッド化合物（PROTAC、SNIPER）2021
- Author(s)
  内藤幹彦
- Journal Title
  
  細胞
  
  Volume: 53 Pages: 136-139
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
- Author(s)
  Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 12 Pages: 236-241
- DOI
  10.1021/acsmedchemlett.0c00605
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502
[Journal Article] Gluing Proteins for Targeted Degradation2021
- Author(s)
  Naito Mikihiko、Murata Shigeo
- Journal Title
  
  Cancer Cell
  
  Volume: 39 Pages: 19-21
- DOI
  10.1016/j.ccell.2020.12.020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.2020
- Author(s)
  Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
- Journal Title
  
  J. Cell Biol.
  
  Volume: 219 Pages: 1-1
- DOI
  10.1083/jcb.201912144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237
[Journal Article] 脱ユビキチン化酵素阻害によるプロテインノックダウン2020
- Author(s)
  柴田識人、内藤幹彦
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2337-2341
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
- Author(s)
  Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Pages: 74-74
- DOI
  10.3390/ph13040074
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551
[Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.2020
- Author(s)
  Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
- Journal Title
  
  Bioorg Med Chem.
  
  Volume: 28 Pages: 115595-115595
- DOI
  10.1016/j.bmc.2020.115595
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety2020
- Author(s)
  Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
- Journal Title
  
  Pharmaceuticals
  
  Volume: 13 Pages: 34-34
- DOI
  10.3390/ph13030034
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502
[Journal Article] プロテインノックダウン技術の沿革と今後の展開2020
- Author(s)
  内藤幹彦
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2300-2304
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.2020
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
- Journal Title
  
  Oncogene
  
  Volume: - Pages: 3867-3878
- DOI
  10.1038/s41388-020-1253-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502
[Journal Article] 開発経緯と最新の動向2020
- Author(s)
  大岡伸通、内藤幹彦
- Journal Title
  
  FARUAW
  
  Volume: 56 Issue: 1 Pages: 41-45
- DOI
  10.14894/faruawpsj.56.1_41
- ISSN
  0014-8601, 2189-7026
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Journal Article] キメラ化合物PROTAC/SNIPERの作用機序と新たな開発の動向2020
- Author(s)
  大岡伸通、内藤幹彦
- Journal Title
  
  実験医学
  
  Volume: 38 Pages: 2321-2325
- Data Source
  KAKENHI-PLANNED-18H05502
[Journal Article] SNIPERs?Hijacking IAP activity to induce protein degradation2019
- Author(s)
  Naito M, Ohoka N, Shibata N.
- Journal Title
  
  Drug Discov Today Technol.
  
  Volume: 印刷中 Pages: 35-42
- DOI
  10.1016/j.ddtec.2018.12.002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502
[Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues2019
- Author(s)
  Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
- Journal Title
  
  MedChemComm
  
  Volume: 印刷中 Pages: 896-900
- DOI
  10.1039/c9md00166b
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385
[Journal Article] Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs2019
- Author(s)
  Naito M, Ohoka N, Shibata N, Tsukumo Y.
- Journal Title
  
  Frontiers in Chemistry
  
  Volume: 7 Pages: 1-5
- DOI
  10.3389/fchem.2019.00849
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07724, KAKENHI-PLANNED-18H05502
[Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019
- Author(s)
  Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 67 Issue: 3 Pages: 203-209
- DOI
  10.1248/cpb.c18-00567
- NAID
  130007607114
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery2019
- Author(s)
  T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
- Journal Title
  
  Chemical Communications
  
  Volume: 55 Pages: 7792-7795
- DOI
  10.1039/c9cc02203a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502
[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 67 Issue: 3 Pages: 165-172
- DOI
  10.1248/cpb.c18-00703
- NAID
  130007606378
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.2019
- Author(s)
  N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
- Journal Title
  
  ACS Chemical Biology
  
  Volume: 14 Pages: 2822-2832
- DOI
  10.1021/acschembio.9b00704
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340
[Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor alpha degradation.2018
- Author(s)
  Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Pages: 6776-6790
- DOI
  10.1074/jbc.ra117.001091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.2018
- Author(s)
  Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 13549-13549
- DOI
  10.1038/s41598-018-31913-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins2018
- Author(s)
  K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
- Journal Title
  
  . Med. Chem.
  
  Volume: 61 Pages: 576-582
- DOI
  10.1021/acs.jmedchem.7b00413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385
[Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib2017
- Author(s)
  Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1032-1041
- DOI
  10.1111/cas.13198
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121
[Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017
- Author(s)
  Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Pages: 4985-4988
- DOI
  10.1016/j.bmcl.2017.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 91 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide2017
- Author(s)
  T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Pages: 4478-4481
- DOI
  10.1016/j.bmcl.2017.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic alpha,alpha-disubstituted amino acids as helical promoters2017
- Author(s)
  Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
- Journal Title
  
  Bioorganic & Medicinal Chemistry
  
  Volume: 25(6) Pages: 1846-1851
- DOI
  10.1016/j.bmc.2017.01.044
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26290055, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017
- Author(s)
  Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1657-1666
- DOI
  10.1111/cas.13284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)2017
- Author(s)
  Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Pages: 4556-4570
- DOI
  10.1074/jbc.m116.768853
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
[Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation2017
- Author(s)
  Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 8 Pages: 1042-1047
- DOI
  10.1021/acsmedchemlett.7b00247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands2017
- Author(s)
  Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 61 Pages: 543-575
- DOI
  10.1021/acs.jmedchem.7b00168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016
- Author(s)
  Ohoka, N., Shibata, N., Hattori, T. & Naito, M.
- Journal Title
  
  Curr Cancer Drug Targets
  
  Volume: 16 Pages: 136-146
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090
[Journal Article] Development of a peptide-based inducer of nuclear receptors degradation2016
- Author(s)
  Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 26 Pages: 2655-2658
- DOI
  10.1016/j.bmcl.2016.04.013
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.2016
- Author(s)
  K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1366 Pages: 549-560
- DOI
  10.1007/978-1-4939-3127-9_42
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
[Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016
- Author(s)
  Ohoka N, Shibata N, Hattori T, Naito M.
- Journal Title
  
  Curr. Cancer Drug Targets.
  
  Volume: 16 Pages: 136-146
- DOI
  10.2174/1568009616666151112122502
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Pages: 1865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article] Degradation of stop codon read-through mutant proteins via the ubiquitin-proteasome system causes hereditary disorders.2015
- Author(s)
  Shibata N, Ohoka N, Sugaki Y, Onodera C, Inoue M, Sakuraba Y, Takakura D, Hashii N, Kawasaki N, Gondo Y, Naito M
- Journal Title
  
  J. Biol. Chem
  
  Volume: 290 Pages: 28428-28437
- DOI
  10.1074/jbc.m115.670901
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-25460084
[Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.2015
- Author(s)
  Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 25 Pages: 5362-5366
- DOI
  10.1016/j.bmcl.2015.09.030
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049
[Journal Article] Apollon protein promotes early mitotic cyclin A degradation independent of the spindle assembly checkpoint2014
- Author(s)
  Kikuchi, R., Ohata, H., Ohoka, N., Kawabata, A., Naito, M.
- Journal Title
  
  J Biol Chem
  
  Volume: 289 Pages: 3457-3467
- DOI
  10.1074/jbc.m113.514430
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25460084
[Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator2014
- Author(s)
  Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Pages: 87-89
- DOI
  10.1016/j.bmcl.2013.11.078
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Apollon/Bruce is upregulated by Humanin.2014
- Author(s)
  4.Hashimoto, Y., Takeshita, Y., Naito, M., Uchino, H. and Matsuoka, M
- Journal Title
  
  Molecular and Cellular Biochemistry
  
  Volume: 397 Pages: 147-155
- DOI
  10.1007/s11010-014-2182-4
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-25460343
[Journal Article] Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.2014
- Author(s)
  1.Ohoka, N., Nagai, K., Hattori, T., Okuhira, K., Shibata, N., Cho, N. and Naito, M
- Journal Title
  
  Cell Death and Disease
  
  Volume: 5
- DOI
  10.1038/cddis.2014.471
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26860049
[Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription2014
- Author(s)
  2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
- Journal Title
  
  Bioconjugate Chem.
  
  Volume: 25 Pages: 1921-1924
- DOI
  10.1021/bc500480e
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
[Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013
- Author(s)
  Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Pages: 1492-1498
- DOI
  10.1111/cas.12272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084
[Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist2012
- Author(s)
  Itoh, Y., Ishikawa, M., Kitaguchi, R., Okuhira, K., Naito, M. & Hashimoto, Y.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 22 Pages: 4453-4457
- Data Source
  KAKENHI-PROJECT-23659048
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
- Author(s)
  Demizu, Y., Okuhira, K., Motoi, H., Ohno, A., Shoda, T., Fukuhara, K., Okuda, H., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg Med Chem Lett
  
  Volume: 22 Pages: 1793-1796
- Data Source
  KAKENHI-PROJECT-23659048
[Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.2012
- Author(s)
  Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
- Journal Title
  
  Bioorg.Med.Chem.Lett.
  
  Volume: 22 Pages: 1793-1796
- DOI
  10.1016/j.bmcl.2011.11.086
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylatlon induced by hybrid molecules that crosslink cIAP1 and the target protein2012
- Author(s)
  K. Okuhira, N. Ohoka, K. Sai, T. Nishimaki-Mogami, Y. Itoh, M. Ishikawa, Y. Hashimoto, M. Naito
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 1147-1152
- DOI
  10.1016/j.febslet.2011.03.019
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
[Journal Article] Design, synthesis and biological evaluation of nuclear receptor-degradation inducers.2011
- Author(s)
  Itoh, Y., Kitaguchi, R., Ishikawa, M., Naito, M. & Hashimoto, Y.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19 Pages: 6768-6778
- Data Source
  KAKENHI-PROJECT-23659048
[Journal Article] Development of target protein-selective degradation inducer for protein knockdown2011
- Author(s)
  Itoh, Y., Ishikawa, M., Kitaguchi, R., Sato, S., Naito, M. & Hashimoto, Y.
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19 Pages: 3229-3241
- Data Source
  KAKENHI-PROJECT-23659048
[Journal Article] Development of target proteinselective degradation inducer for protein knockdown2011
- Author(s)
  Y. Itoh, M. Ishikawa, R. Kitaguchi, S. Sato, M. Naito, Y. Hashimoto
- Journal Title
  
  Bioorg Med Chem
  
  Volume: 19 Pages: 3229-3241
- DOI
  10.1016/j.bmc.2011.03.057
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-23659048
[Journal Article] Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein2011
- Author(s)
  Okuhira, K., Ohoka, N., Sai, K., Nishimaki-Mogami, T., Itoh, Y., Ishikawa, M., Hashimoto, Y. & Naito, M.
- Journal Title
  
  FEBS Lett
  
  Volume: 585 Pages: 1147-1152
- Data Source
  KAKENHI-PROJECT-23659048
[Journal Article] Impairment of the ubiquitin-proteasome system by cellular FLIP.2007
- Author(s)
  Ishioka, T., Katayama, R., Kikuchi, R., Nishimoto, M., Takada, S., Takada, R., Matsuzawa, S.I., Reed, J.C., Tsuruo, T., Naito, M.
- Journal Title
  
  Genes Cells 12
  
  Pages: 735-744
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390017
[Journal Article] Brain pericytes contribute to the induction and up-regulation of blood-brain barrier functions through transforming growth factor-beta production.2005
- Author(s)
  Dohgu, S., Takata, F., Yamauchi, A., Nakagawa, S., Egawa, T., Naito, M., Tsuruo, T., Sawada, Y., Niwa, M., Kataoka, Y.
- Journal Title
  
  Brain Res 1038
  
  Pages: 208-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390017
[Journal Article] Cell differentiation inducers derived from thalidomide.2005
- Author(s)
  Noguchi, T., Miyachi, H., Katayama, R., Naito, M., Hashimoto, Y.
- Journal Title
  
  Bioorg Med Chem Lett 15
  
  Pages: 3212-5
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390017
[Journal Article] HtrA2 cleaves Apollon and induces cell death by IAP-binding motif in Apollon-deficient cells.2005
- Author(s)
  Sekine, K., Hao, Y., Suzuki, Y., Takahashi, R., Tsuruo, T., Naito, M.
- Journal Title
  
  Biochem Biophys Res Commun 330
  
  Pages: 279-85
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390017
[Journal Article] Functional characterization of adenosine transport across the BBB in mice.2005
- Author(s)
  Murakami, H., Ohkura, A., Takanaga, H., Matsuo, H., Koyabu, N., Naito, M., Tsuruo, T., Ohtani, H., Sawada, Y.
- Journal Title
  
  Int J Pharm 290
  
  Pages: 37-44
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390017
[Patent] 新規化合物及び医薬組成物2021
- Inventor(s)
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Holder
  出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-016808
- Filing Date
  2021
- Data Source
  KAKENHI-PLANNED-18H05502
[Patent] 複素環化合物2016
- Inventor(s)
  内藤幹彦, 大岡伸通, 柴田識人, 奥平桂一郎, 他12名
- Industrial Property Rights Holder
  内藤幹彦, 大岡伸通, 柴田識人, 奥平桂一郎, 他12名
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2016-196803
- Filing Date
  2016-10-04
- Data Source
  KAKENHI-PROJECT-26860049
[Patent] アポトーシス阻害タンパク質リガンド－エストロゲン受容体リガンドハイブリッド化合物並びにそれを利用したエストロゲン受容体分解誘導剤及び乳癌、子宮頚癌又は卵巣癌の予防及び治療剤2011
- Inventor(s)
  内藤幹彦、奥平桂一郎、出水庸介、栗原正明
- Industrial Property Rights Holder
  内藤幹彦、奥平桂一郎、出水庸介、栗原正明
- Industrial Property Number
  2011-195081
- Filing Date
  2011
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] 標的タンパク質を分解するプロテインノックダウン技術2021
- Author(s)
  内藤幹彦
- Organizer
  第99回産研テクノサロン
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] タンパク質の選択的分解技術と細胞機能制御2021
- Author(s)
  内藤幹彦
- Organizer
  千里ライフサイエンスセミナーP5
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 核内受容体分解誘導ペプチドの創製2020
- Author(s)
  横尾英知，大岡伸通，内藤幹彦，出水庸介
- Organizer
  日本薬学会第140回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Targeted Protein Degradation by Small Molecules2020
- Author(s)
  Mikihiko Naito
- Organizer
  第79回日本癌学会総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 化合物による標的タンパク質分解技術と創薬2020
- Author(s)
  内藤幹彦
- Organizer
  第69回バイオインターフェイス
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPERを用いたユビキチンプロテアソーム創薬2020
- Author(s)
  内藤幹彦
- Organizer
  第93回日本薬理学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] SNIPER化合物によるケミカルプロテインノックダウン技術の開発と細胞制御2020
- Author(s)
  内藤幹彦
- Organizer
  日本化学会第100春期年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019
- Author(s)
  Mikihiko Naito
- Organizer
  第78回日本癌学会学術総会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019
- Author(s)
  内藤幹彦
- Organizer
  日本薬学会第35回創薬セミナー
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質を特異的に分解するハイブリッド型低分子化合物SNIPERの開発と応用2019
- Author(s)
  内藤幹彦
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019
- Author(s)
  内藤幹彦
- Organizer
  日本薬学会第35回創薬セミナー
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019
- Author(s)
  内藤幹彦
- Organizer
  日本再生医療
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2019
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
- Organizer
  日本薬学会第139年会　国際創薬シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質を特異的に分解するハイブリッド型低分子化合物SNIPERの開発と応用2019
- Author(s)
  内藤幹彦
- Organizer
  第24回日本病態プロテアーゼ学会学術集会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook.2019
- Author(s)
  Mikihiko Naito
- Organizer
  Targeted Protein Degradation forum in Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2019
- Author(s)
  大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPER化合物によるプロテインノックダウン2019
- Author(s)
  内藤幹彦
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  Misawa T, Ohoka N, Goto C, Oba M, Tanaka M, Naito M, Demizu Y.
- Organizer
  European Symposium on Organic Chemistry
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  ケミカルバイオロジー第14回年会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 細胞内の標的タンパク質を特異的に分解するプロテインノックダウン技術の開発2019
- Author(s)
  内藤幹彦
- Organizer
  日本再生医療学会　第１回秋季科学シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] キメラ型タンパク質分解薬SNIPERの開発2019
- Author(s)
  内藤幹彦
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 次世代の医薬品開発プラットフォーム技術：プロテインノックダウン法の開発2019
- Author(s)
  内藤幹彦
- Organizer
  東北大学大学院薬学系研究科医薬品開発研究センターキックオフシンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Induced Protein Degradation by Chimeric Small Molecules; Recent Progress and Outlook2019
- Author(s)
  Mikihiko Naito
- Organizer
  Targeted Protein Degradation forum in Japan
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 次世代の医薬品開発プラットフォーム技術：プロテインノックダウン法の開発2019
- Author(s)
  内藤幹彦
- Organizer
  東北大学大学院薬学系研究科医薬品開発研究センターキックオフシンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation2019
- Author(s)
  Mikihiko Naito
- Organizer
  2nd Annual Targeted Protein Degradation Summit
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第56回ペプチド討論会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPER化合物によるプロテインノックダウン2019
- Author(s)
  内藤幹彦
- Organizer
  第42回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第37回メディシナルケミストリーシンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] IAPを利用して細胞内の標的タンパク質を分解するプロテインノックダウン技術の開発2019
- Author(s)
  内藤幹彦
- Organizer
  第28回日本Cell Death学会学術集会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation.2019
- Author(s)
  Mikihiko Naito
- Organizer
  Symposium on Frontier in PROTAC Drug Discovery and Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] キメラ型タンパク質分解薬SNIPERの開発2019
- Author(s)
  内藤幹彦
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019
- Author(s)
  三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第13回バイオ関連化学シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 化合物による標的タンパク質分解技術と創薬2019
- Author(s)
  内藤幹彦
- Organizer
  第69回バイオインターフェイス
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019
- Author(s)
  三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] IAPを利用して細胞内の標的タンパク質を分解するプロテインノックダウン技術の開発2019
- Author(s)
  内藤幹彦
- Organizer
  第28回日本Cell Death学会学術集会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPERs: Hijacking IAP Ubiquitin Ligases for Targeted Protein Degradation2019
- Author(s)
  Mikihiko Naito
- Organizer
  2nd Annual Targeted Protein Degradation Summit
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Hijacking IAP ubiquitin ligases by SNIPERs to induce protein degradation2019
- Author(s)
  Mikihiko Naito
- Organizer
  Symposium on Frontier in PROTAC Drug Discovery and Development
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] SNIPERによるプロテインノックダウン技術の開発2018
- Author(s)
  内藤幹彦
- Organizer
  理研第４回DMP創薬ワークショップ
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
- Organizer
  日本薬学会第139年会　国際創薬シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018
- Author(s)
  内藤幹彦
- Organizer
  第62回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2018
- Author(s)
  内藤幹彦、大岡伸通、柴田識人、服部隆行
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018
- Author(s)
  Mikihiko Naito
- Organizer
  EFMC-ISMC 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2018
- Author(s)
  大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
- Organizer
  日本薬学会第139年会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018
- Author(s)
  Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] SNIPERによるプロテインノックダウン技術の開発2018
- Author(s)
  内藤幹彦
- Organizer
  理研第４回DMP創薬ワークショップ
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases2018
- Author(s)
  Mikihiko Naito
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2018
- Author(s)
  Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018
- Author(s)
  Mikihiko Naito
- Organizer
  薬物動態懇話会第41回年会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018
- Author(s)
  Mikihiko Naito
- Organizer
  薬物動態懇話会第41回年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPのユビキチンリガーゼ活性を利用した標的蛋白質分解誘導剤SNIPERの開発2018
- Author(s)
  内藤幹彦
- Organizer
  日経バイオテクプロフェッショナルセミナー　低分子薬の新たなモダリティ：標的蛋白質分解誘導薬の最前線
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPのユビキチンリガーゼ活性を利用した標的蛋白質分解誘導剤SNIPERの開発2018
- Author(s)
  内藤幹彦
- Organizer
  日経バイオテクプロフェッショナルセミナー　低分子薬の新たなモダリティ：標的蛋白質分解誘導薬の最前線
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018
- Author(s)
  内藤幹彦
- Organizer
  第62回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] SNIPERによるプロテインノックダウン技術の開発2018
- Author(s)
  内藤幹彦
- Organizer
  理研第４回DMP創薬ワークショップ
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPによる細胞死・細胞周期制御とIAPのユビキチンリガーゼ活性を利用したプロテインノックダウン法の開発2018
- Author(s)
  内藤幹彦
- Organizer
  日本がん分子標的治療学会　鶴尾隆賞　受賞講演
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018
- Author(s)
  出水庸介，三澤隆史，大岡伸通，服部隆行，内藤幹彦
- Organizer
  第 44 回反応と合成の進歩シンポジウム
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018
- Author(s)
  Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Inducing target-specific protein degradation by SNIPER compounds recruiting IAP ubiquitin ligases2018
- Author(s)
  Mikihiko Naito
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2018
- Author(s)
  Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 標的タンパク質を分解する新しい創薬技術、プロテインノックダウン法の開発2018
- Author(s)
  内藤幹彦
- Organizer
  第91回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 標的タンパク質を分解する新しい創薬技術、プロテインノックダウン法の開発2018
- Author(s)
  内藤幹彦
- Organizer
  第91回日本内分泌学会学術総会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] キメラ型タンパク質分解薬SNIPERの開発2018
- Author(s)
  内藤幹彦
- Organizer
  日本薬学会第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPによる細胞死・細胞周期制御とIAPのユビキチンリガーゼ活性を利用したプロテインノックダウン法の開発2018
- Author(s)
  内藤幹彦
- Organizer
  日本がん分子標的治療学会　鶴尾隆賞　受賞講演
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018
- Author(s)
  Mikihiko Naito
- Organizer
  EFMC-ISMC 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] Development of Protein Knockdown Technology to Induce Selective Degradation of Target Proteins2018
- Author(s)
  Mikihiko Naito
- Organizer
  薬物動態懇話会第41回年会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] A novel strategy for destabilizion of oncogenic fusion protein BCR-ABL to inhibit the growth of chronic myelogenous leukemea2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Mikihiko Naito
- Organizer
  日本薬学会第139年会　国際創薬シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] Recent Advances in Bifunctional Degrader Molecules (e.g. SNIPER) for Targeted Protein Degradation via the Ubiquitin Proteasome System; Status and Outlook2018
- Author(s)
  Mikihiko Naito
- Organizer
  EFMC-ISMC 2018
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05502
[Presentation] 標的タンパク質を分解するプロテインノックダウン技術の開発と創薬への応用2018
- Author(s)
  内藤幹彦
- Organizer
  第62回日本薬学会関東支部大会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析2017
- Author(s)
  築茂由則、鈴木孝昌、内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017
- Author(s)
  柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2017
- Author(s)
  内藤幹彦、大岡伸通、柴田識人、服部隆行
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017
- Author(s)
  大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第21回日本がん分子標的治療学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017
- Author(s)
  Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  EMBO conference　Ubiquitin and SUMO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低コピーEGFR L858R変異アレルを有する細胞の作製とEGFR阻害剤感受性の解析2017
- Author(s)
  築茂由則、鈴木孝昌、内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、柴田識人、服部隆行、内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製2017
- Author(s)
  鈴木孝昌、築茂由則、内藤幹彦、小原有弘
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  EMBO conference　Ubiquitin and SUMO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] NCCオンコパネルの90遺伝子を網羅する変異細胞株パネルの作製2017
- Author(s)
  鈴木孝昌、築茂由則、内藤幹彦、小原有弘
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases2017
- Author(s)
  Mikihiko Naito
- Organizer
  2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、柴田識人、服部隆行、内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017
- Author(s)
  大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第21回日本がん分子標的治療学会　学術集会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Protein knockdown by SNIPER compounds recruiting IAP ubiquitin ligases2017
- Author(s)
  Mikihiko Naito
- Organizer
  2017 Chinese Medicinal Chemistry Symposium, CPA-EFMC International Symposium on Medicinal Chemistry
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017
- Author(s)
  柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017
- Author(s)
  Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2017
- Author(s)
  Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017
- Author(s)
  Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016
- Author(s)
  大岡伸通, 奥平桂一郎, 服部隆行, 内藤幹彦
- Organizer
  第20回日本がん分子標的治療学会
- Place of Presentation
  大分
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases2016
- Author(s)
  Mikihiko Naito
- Organizer
  The 21th 国際化学療法シンポジウム
- Place of Presentation
  日本科学未来館（東京）
- Year and Date
  2016-12-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機構の制御と創薬への応用2016
- Author(s)
  大岡伸通, 奥平桂一郎, 永井克典, 伊東昌宏, 柴田識人, 服部隆行, 宇治川治, 佐野修, 小山亮吉, 今枝泰宏, 奈良洋, 長展生, 内藤幹彦
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016
- Author(s)
  大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016
- Author(s)
  大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016
- Author(s)
  Naito M, Hattori T, Ohoka N, Shibata N, Shoda T, Demizu Y, Kurihara M
- Organizer
  第１０回日米がん合同会議
- Place of Presentation
  ラハイナ
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016
- Author(s)
  服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016
- Author(s)
  大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機能の制御と創薬への利用2016
- Author(s)
  大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016
- Author(s)
  大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016
- Author(s)
  大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016
- Author(s)
  大岡伸通, 伊東昌宏, 奥平桂一郎, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  横浜
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立2016
- Author(s)
  中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] エストロゲン受容体分解誘導剤の分子デザイン2016
- Author(s)
  正田卓司，奥平桂一郎，内藤幹彦，栗原正明
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] In vivo protein knockdown by SNIPER recruiting IAP ubiquitin ligases2016
- Author(s)
  Mikihiko Naito
- Organizer
  The 21th 国際化学療法シンポジウム
- Place of Presentation
  日本科学未来館（東京）
- Year and Date
  2016-12-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15121
[Presentation] 芳香族炭化水素受容体のユビキチンリガーゼ活性を利用した新規標的タンパク質分解誘導剤の開発2016
- Author(s)
  藤里卓磨、正田卓司、大岡伸通、井上英史、内藤幹彦、栗原正明
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京）
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 細胞内His タグタンパク質分解誘導剤の開発2016
- Author(s)
  沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京）
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチン化誘導剤によるユビキチン関連死の解明2015
- Author(s)
  大岡伸通, 永井克典, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会　合同大会）
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Protein knockdown by SNIPER compounds, inducers for target protein-selective degradation2015
- Author(s)
  Naito M
- Organizer
  The 20th 国際化学療法シンポジウム
- Place of Presentation
  東京
- Year and Date
  2015-12-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] Ubiquitin-related cancer cell death induced by small molecules degrading TACC3 protein.2015
- Author(s)
  大岡伸通, 柴田識人, 服部隆行, 内藤幹彦
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] Degradation of C-terminally extended proteins by stop codon read-through mutations cause hereditary disorders2015
- Author(s)
  Shibata N, Ohoka N, Gondo Y, Naito M
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015
- Author(s)
  大岡伸通, 服部隆行, 内藤幹彦
- Organizer
  第19回日本がん分子標的治療学会学術集会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015
- Author(s)
  大岡伸通、柴田識人、服部隆行、内藤幹彦
- Organizer
  第19回日本がん分子標的治療学会　学術集会
- Place of Presentation
  松山
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells.2014
- Author(s)
  Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M.
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
- Place of Presentation
  Bigsky
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014
- Author(s)
  大岡伸通，大畑広和，内藤幹彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014
- Author(s)
  Ohoka N, Ohata H, Naito M.
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
- Place of Presentation
  Bigsky
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] エストロゲン受容体分解誘導剤による乳癌の細胞死誘導分子機構2014
- Author(s)
  奥平桂一郎，出水庸介，服部隆行，大岡伸通，柴田識人，最上（西巻）知子，栗原正明，奥田晴宏，内藤幹彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2014
- Author(s)
  Ohoka N, Ohata H, Naito M.
- Organizer
  Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
- Place of Presentation
  Bigsky
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する2014
- Author(s)
  大岡伸通，大畑広和，内藤幹彦
- Organizer
  日本薬学会第134年会
- Place of Presentation
  熊本
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation followed by rapid cell death in breast cancer cells2013
- Author(s)
  Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
- Organizer
  Ninth AACR-Japanese Cancer Association Joint Conference: Breakthroughs in Basic and Translational Cancer Research
- Place of Presentation
  ラハイナ市、米国
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン効果の検討2013
- Author(s)
  奥平桂一郎，大岡伸通，最上（西巻）知子，伊藤幸裕，石川稔，橋本祐一，内藤幹彦
- Organizer
  第17回日本がん分子標的治療学会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013
- Author(s)
  Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami, T, Okuda H, Kurihara M, Naito M.
- Organizer
  AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Boston
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013
- Author(s)
  大岡伸通，大畑広和，内藤幹彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の評価2013
- Author(s)
  奥平桂一郎,大岡伸通,最上(西巻)知子,伊藤幸裕,石川稔,橋本祐一,内藤幹彦
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Apollon binds cyclin A and promotes degradation in early mitosis independent of spindle assembly checkpoint2013
- Author(s)
  大岡伸通，大畑広和，内藤幹彦
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] 乳癌におけるエストロゲンレセプターの分解を誘導する分子SNIPER(ER)の開発2012
- Author(s)
  奥平桂一郎, 出水庸介, 大岡伸通, 柴田識人, 服部隆行, 最上(西巻)知子, 奥田晴宏, 栗原正明, 内藤幹彦
- Organizer
  第16回日本がん分子標的治療学会
- Place of Presentation
  北九州市
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins2012
- Author(s)
  Naito, M., Okuhira, K., Ohoka, N., Shibata, N., Hattori, T., Itoh, Y., Ishikawa, M., Hashimoto, Y.
- Organizer
  The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
- Place of Presentation
  ヒューストン市、米国
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Degradation of estrogen receptor induced by a small hybrid molecule SNIPER(ER)2012
- Author(s)
  奥平桂一郎、出水庸介、大岡伸通、柴田識人、服部隆行、最上(西巻)知子、栗原正明、奥田晴宏、内藤幹彦
- Organizer
  The 16th JFCR-ISCC
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] プロテインノックダウン法によるエストロゲンレセプターの分解2012
- Author(s)
  奥平桂一郎, 出水庸介, 大岡伸通, 柴田識人, 服部隆行, 最上（西巻）知子, 栗原正明, 奥田晴宏, 内藤幹彦
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation2012
- Author(s)
  Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
- Organizer
  The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
- Place of Presentation
  Houston
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner2012
- Author(s)
  Naito, M., Okuhira, K., Demizu, Y., Itoh, Y., Ishikawa, M., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Hashimoto, Y.
- Organizer
  Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
- Place of Presentation
  ボストン市、米国
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] プロテインノックダウン法を利用したエストロゲン受容体分解誘導剤の開発2012
- Author(s)
  元井宏美, 出水庸介, 佐藤由紀子, 奥平桂一郎, 内藤幹彦, 栗原正明
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] M.:Development of SNIPER(ER) that induces estrogen receptor degradation2012
- Author(s)
  Okuhira, K., Demizu, Y., Ohoka, N., Shibata, N., Hattori, T., Nishimaki-Mogami, T., Kurihara, M., Okuda, H., Naito, M.
- Organizer
  The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
- Place of Presentation
  ヒューストン市、米国
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins in a specific manner2012
- Author(s)
  内藤幹彦
- Organizer
  Cell Symposia: Genetics and Chemistry Sharing a Language of Discovery
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Development of small molecules that induce IAP-mediated ubiquitylation and proteasomal degradation of target proteins2012
- Author(s)
  Naito, M., Okuhira, K., Ohoka, N., Shibata, N., Hattori, T., Itoh, Y., Ishikawa, M., Hashimoto, Y.
- Organizer
  The 6th International Conference SUMO, Ubiquitin, UBL Proteins: Implications for Human Diseases
- Place of Presentation
  Houston
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Design and Synthesis of ER Degradation Inducer for Protein Knockdown Strategy2011
- Author(s)
  Yosuke Demizu, Hiromi Motoi, Keiichiro Okuhira, Kiyoshi Fukuhara, Haruhiro Okuda, Mikihiko Naito, and Masaaki Kurihara
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Protein Knockdown: Selective Degradation of Target Proteins in Cells Using Methyl Bestatin-ligand Hybrid Molecules2011
- Author(s)
  Minoru Ishikawa, Yukihiro Itoh, Risa Kitaguchi, Shinichi Sato, Mikihiko Naito, and Yuichi Hashimoto
- Organizer
  8th AFMC International Medicinal Chemistry Symposium
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] 抗がん剤、がん分子標的治療薬の作用機序と薬剤耐性の分子機構2011
- Author(s)
  内藤幹彦
- Organizer
  第55回日本薬学会関東支部大会(招待講演)
- Place of Presentation
  船橋
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] プロテインノックダウン法によるエストロゲン受容体の分解2011
- Author(s)
  奥平桂一郎、出水庸介、大岡伸通、柴田識人、服部隆行、最上（西巻）知子、栗原正明、奥田晴宏、内藤幹彦
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン技術の検討2011
- Author(s)
  奥平桂一郎、大岡伸通、最上（西巻）知子、伊藤幸裕、石川稔、橋本祐一、内藤幹彦
- Organizer
  第15回日本がん分子標的治療学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23659048
[Presentation] Regulation of Cell Death and Cell Cycle by IAPs2009
- Author(s)
  内藤幹彦
- Organizer
  第14回分生研シンポジウム
- Place of Presentation
  東京大学安田講堂
- Year and Date
  2009-10-28
- Data Source
  KAKENHI-PROJECT-20058008
[Presentation] Drug resistance and apoptosis of cancer cells2009
- Author(s)
  内藤幹彦
- Organizer
  The 14th JFCR lnternational Symposium on Cancer Chemotherapy
- Place of Presentation
  日航ホテル(東京)
- Year and Date
  2009-12-02
- Data Source
  KAKENHI-PROJECT-20015012
[Presentation] Small molecules destabilize cIAP1 by activating auto-ubinuitylation2008
- Author(s)
  Naito M, et.al.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Lucca, Italy
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20015012
[Presentation] Small molecules destabilize cIAP1 by activating auto-ubiquitylation2008
- Author(s)
  Naito M, et.al.
- Organizer
  Gordon Research Conference
- Place of Presentation
  Lucca, Italy
- Year and Date
  2008-07-10
- Data Source
  KAKENHI-PROJECT-20058008
[Presentation] Molecular function of IAPs and its implication in cancer.2007
- Author(s)
  内藤幹彦
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18659017
[Presentation] Molecular function of IAPs and its implication in cancer.2007
- Author(s)
  内藤幹彦
- Organizer
  第66回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-10-05
- Data Source
  KAKENHI-PROJECT-18015009
[Presentation] Protein Knockdown: Targeted Destruction of Pathogenic Proteins by SNIPER Compounds
- Author(s)
  M. Naito
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導.
- Author(s)
  大岡伸通, 奥平桂一郎, 柴田識人, 服部隆行, 内藤幹彦
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価
- Author(s)
  大岡伸通、永井克典、服部隆行、奥平桂一郎、柴田識人、長展生、内藤幹彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導.
- Author(s)
  大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤の開発と抗がん活性評価.
- Author(s)
  大岡伸通, 永井克典, 服部隆行,奥平桂一郎, 柴田識人,長展生, 内藤幹彦
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-25 – 2015-03-28
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.
- Author(s)
  Nobumichi Ohoka, Katsunori Nagai, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
- Organizer
  26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-11-18 – 2014-11-21
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤による癌細胞死の誘導
- Author(s)
  大岡伸通，永井克典，奥平桂一郎，柴田識人，服部隆行，長展生，内藤幹彦
- Organizer
  第37回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2014-11-25 – 2014-11-27
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] 終止コドンのリードスルー変異によるユビキチン-プロテアソーム系を介した蛋白質の不安定化
- Author(s)
  柴田　識人，大岡伸通，権藤　洋一，内藤　幹彦
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] SNIPER(TACC3) degrades TACC3 protein via the ubiquitin-proteasome pathway and induces apoptosis in cancer cells expressing a large amount of TACC3.
- Author(s)
  大岡伸通, 永井克典, 奥平桂一郎, 柴田識人, 服部隆行, 長展生, 内藤幹彦
- Organizer
  26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2014-11-18 – 2014-11-21
- Data Source
  KAKENHI-PROJECT-26860049
[Presentation] SNIPER: Inducing protein degradation via recruitment to IAP
- Author(s)
  M. Naito
- Organizer
  248th ACS National Meeting and Exposition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-08-10 – 2014-08-14
- Invited
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] Apollon細胞分裂初期においてスピンドルチェックポイント非依存的なcyclin Aの分解を促進する
- Author(s)
  大岡伸通，内藤幹彦
- Organizer
  日本がん分子標的治療学会第18回学術集会
- Place of Presentation
  仙台
- Year and Date
  2014-06-25 – 2014-06-27
- Data Source
  KAKENHI-PROJECT-25460084
[Presentation] Destabilization of carboxy-terminally extended proteins encoded by stop codon read-through mutation via ubiquitin-proteasome system
- Author(s)
  柴田　識人，大岡伸通，櫻庭　喜行，権藤　洋一，内藤　幹彦
- Organizer
  Symposium for young ubiquitin researchers in Japan“New Era in the Ubiquitin Research”
- Place of Presentation
  京都
- Year and Date
  2014-11-11 – 2014-11-12
- Data Source
  KAKENHI-PUBLICLY-25112521
[Presentation] ユビキチン・プロテアソームシステムを利用したTACC3分解誘導剤によるがん細胞死の誘導
- Author(s)
  大岡伸通，奥平桂一郎，柴田識人，服部隆行，内藤幹彦
- Organizer
  第73回日本癌学会学術集会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PUBLICLY-25112521

1. 鶴尾隆 (00012667)

# of Collaborated Projects: 5 results

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2. DEMIZU Yosuke (90389180)

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5. 橋田充 (20135594)

# of Collaborated Projects: 3 results

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6. 谷川允彦 (00111956)

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7. 西條長宏 (00215526)

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8. 加藤哲郎 (40004642)

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9. Ohoka Nobumichi (80568519)

# of Collaborated Projects: 2 results

# of Collaborated Products: 49 results
10. 田代田鶴子 (50085635)

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11. 冨田章弘 (40251483)

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12. 中島元夫 (90240738)

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13. 遊佐敬介 (30200869)

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14. 口野嘉幸 (60124418)

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15. 須田貴司 (70250090)

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16. 高橋秀史 (40231394)

# of Collaborated Projects: 2 results

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17. 田代田鶴子 (20085608)

# of Collaborated Projects: 1 results

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18. 永沼章 (80155952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 瀬戸治男 (10013335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 吉田稔 (80191617)

# of Collaborated Projects: 1 results

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21. 長田裕之 (80160836)

# of Collaborated Projects: 1 results

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Naito Mikihiko 内藤 幹彦

NAITO Mikihiko 内藤 幹彦

内藤 幹彦

Research Projects

Research Products

Co-Researchers

がん特異的融合タンパク質の分解を阻害する脱ユビキチン化酵素と分子標的治療Principal Investigator

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New frontier for ubiquitin biology driven by chemo-technologies

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Chemical protein knockdown technology and cell regulationPrincipal Investigator

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Manipulation of cellular function by forced ubiquitylationPrincipal Investigator

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Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technologyPrincipal Investigator

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Development of novel small molecules degrading microtubule-associated proteins

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ケミカルバイオロジーを利用した人工的ユビキチン修飾システムの開発Principal Investigator

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Mitosis regulation by ApollonPrincipal Investigator

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Development of protein knockdown technology to degrade pathogenic proteinsPrincipal Investigator

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細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

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Apollonによる細胞周期制御因子のユビキチン化と細胞分裂期の制御Principal Investigator

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細胞死阻害タンパク質の機能解析とがん治療への応用Principal Investigator

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巨大タンパク質HERC2の機能解析Principal Investigator

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Naito Mikihiko 内藤幹彦

NAITO Mikihiko 内藤幹彦

内藤幹彦