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Demizu Yousuke  出水 庸介

… Alternative Names

DEMIZU Yosuke  出水 庸介

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Researcher Number 90389180
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-7521-4861
Affiliation (Current) 2021: 国立医薬品食品衛生研究所, 有機化学部, 部長
2021: 横浜市立大学, 生命医科学研究科, 客員教授
Affiliation (based on the past Project Information) *help 2017 – 2021: 国立医薬品食品衛生研究所, 有機化学部, 部長
2014 – 2016: 国立医薬品食品衛生研究所, 有機化学部, 室長
2015: 国立医薬品食品研究所, 有機化学部, 室長
2012: 国立医薬品食品衛生研究所, 有機化学部
2008 – 2010: National Institute of Health Sciences, 有機化学部, 研究官 … More
2008: National Institute of Health Sciences, 研究官
2007: Nagasaki University, 大学院・医歯薬学総合研究科, 助教
2006: 長崎大学, 大学院医歯薬学総合研究科, 助手
2005: 徳島文理大学, 香川薬学部, 助手 Less
Review Section/Research Field
Principal Investigator
Chemical pharmacy / Drug development chemistry / Basic Section 37030:Chemical biology-related
Except Principal Investigator
Complex systems / Drug development chemistry / Tumor therapeutics / Biological pharmacy / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
Keywords
Principal Investigator
ペプチド / 非天然型アミノ酸 / 二次構造 / アミノ酸 / フォルダマー / ヘリカル構造 / 中分子ペプチド / PPI阻害 / α,α-ジ置換アミノ酸 / フォールドマー … More / α-ヘリックス / 3_<10>-ヘリックス / 計算化学 / 電極酸化 / フォールダマー / N-オキシル / 電極反応 / 酸化反応 / 環状アミン / コンフォメーション / ペプチド触媒 / PPI阻害剤 / 標的タンパク質分解誘導剤 / 細胞膜透過性ペプチド / ユビキチン-プロテアソームシステム / Hisタグタンパク質 / 膜透過ペプチド / タンパク質分解誘導剤 / プロテインノックダウン / 癌 / 二次構造制御 / 分解誘導剤 / 核内受容体 / DDSキャリア / Post-modification / 二次構造解析 / ヘリックス … More
Except Principal Investigator
ペプチド / ユビキチン / ヘリカルペプチド / エストロゲン受容体 / SNIPER / プロテアソーム / タンパク質分解 / ステープルペプチド / 核内レセプター / コアクチベータ / ヘリックス / ビタミンＤレセプター / 転写阻害 / ビタミンDレセプター / 乳癌 / エストロゲンレセプター / プロテインノックダウン / Notch / 蛋白質分解 / 核内受容体 / 蛋白質 / ペプチド核酸 / ゲノム / 有機化学 / 核酸医薬 / アンチジーン / 人工核酸 / 人工塩基 / ケミカルプロテインノックダウン / PROTAC / セレブロンモジュレーター / サリドマイド / 血管新生 / 脱ユビキチン化酵素 / セレブロン / IAP / ケミカルバイオロジー / 翻訳後修飾 Less

  • Research Projects

    (12 results)

  • Research Products

    (575 results)

  • Co-Researchers

    (51 People)

  •  革新的中分子医薬品創出を目指したペプチドフォルダマー研究Principal Investigator

    • Principal Investigator
      出水 庸介
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 37030:Chemical biology-related
    • Research Institution
      National Institute of Health Sciences

  •  アンチジーン法における配列制限の克服を目指したペプチド核酸の医薬分子設計

    • Principal Investigator
      杉山 亨
    • Project Period (FY)
      2018 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Teikyo University

  •  Chemical protein knockdown technology and cell regulation

    • Principal Investigator
      内藤 幹彦
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      The University of Tokyo
      National Institute of Health Sciences

  •  New frontier for ubiquitin biology driven by chemo-technologies

    • Principal Investigator
      佐伯 泰
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Complex systems
    • Research Institution
      Tokyo Metropolitan Institute of Medical Science

  •  二次構造制御を基軸としたペプチド創薬研究Principal Investigator

    • Principal Investigator
      出水 庸介
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Health Sciences

  •  Design of peptide ligands based on protein-protein interaction and their application to protein knockdown technology

    • Principal Investigator
      Naito Mikihiko
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences

  •  Development of stabilized helical peptides as POI degradation inducersPrincipal Investigator

    • Principal Investigator
      DEMIZU YOSUKE
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Health Sciences

  •  Development of estrogen receptor degrader and analysis of drug-induced cell death mechanism for breast cancer therapy

    • Principal Investigator
      OKUHIRA Keiichiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      The University of Tokushima
      National Institute of Health Sciences

  •  Design of a stabilized short helical peptide and its application

    • Principal Investigator
      KURIHARA Masaaki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Drug development chemistry
    • Research Institution
      National Institute of Health Sciences

  •  Design of proline analogues based on hybrid methods and their applicationPrincipal Investigator

    • Principal Investigator
      DEMIZU Yosuke
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      National Institute of Health Sciences

  •  Design and synthesis of non-proteinogenic amino acids and peptide foldamers by anodic functionalizatonPrincipal Investigator

    • Principal Investigator
      DEMIZU Yosuke
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      National Institute of Health Sciences
      Nagasaki University

  •  ペプチド-フォールドマーのナノ二次構造を利用した機能性分子の創製Principal Investigator

    • Principal Investigator
      出水 庸介
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Chemical pharmacy
    • Research Institution
      Nagasaki University
      Tokushima Bunri University

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 Other

All Journal Article Presentation Book Patent

  • [Book] ペプチド創薬の最前線，第5章「二次構造制御を基軸としたペプチド創薬研究」2019
    • Author(s)
      出水庸介
    • Total Pages
      265
    • Publisher
      CMC出版
    • ISBN
      9784781314174
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Book] 医薬品開発における中分子領域(核酸医薬・ペプチド医薬)の開発戦略，「ペプチド医薬品の品質に関するガイドラインおよび規制の現状」2019
    • Author(s)
      出水庸介，石井明子
    • Total Pages
      206
    • Publisher
      情報機構
    • ISBN
      9784865021769
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Journal Article] Development of a Hematopoietic Prostaglandin D Synthase-Degradation Inducer2021
    • Author(s)
      Yokoo Hidetomo、Shibata Norihito、Naganuma Miyako、Murakami Yuki、Fujii Kiyonaga、Ito Takahito、Aritake Kosuke、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      ACS Medicinal Chemistry Letters

      Volume: 12 Pages: 236-241

    • DOI

      10.1021/acsmedchemlett.0c00605

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K07311, KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502

  • [Journal Article] Synthesis and characterization of PNA oligomers containing preQ1 as a positively charged guanine analogue2021
    • Author(s)
      Moriya Shun-suke、Shibasaki Hatsune、Kohara Misaki、Kuwata Keiko、Imamura Yasutada、Demizu Yosuke、Kurihara Masaaki、Kittaka Atsushi、Sugiyama Toru
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 39 Pages: 127850-127850

    • DOI

      10.1016/j.bmcl.2021.127850

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06556, KAKENHI-PROJECT-18K06557

  • [Journal Article] Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence2021
    • Author(s)
      Hirano Motoharu、Saito Chihiro、Yokoo Hidetomo、Goto Chihiro、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
    • Journal Title

      Molecules

      Volume: 26 Pages: 444-444

    • DOI

      10.3390/molecules26020444

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880

  • [Journal Article] TRIP12 promotes small molecule-induced degradation of BRD4 through K29/K48 branched ubiquitin chains.2021
    • Author(s)
      Kaiho-Soma Ai、Akizuki Yoshino、Igarashi Katsuhide、Endo Akinori、Shoda Takuji、Kawase Yasuko、Demizu Yosuke、Naito Mikihiko、Saeki Yasushi、Tanaka Keiji、Ohtake Fumiaki
    • Journal Title

      Mol Cell

      Volume: 81

    • DOI

      10.1016/j.molcel.2021.01.023

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07009, KAKENHI-PROJECT-20K22726, KAKENHI-PROJECT-17H01882, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-19H00997

  • [Journal Article] Targeted Protein Degrader合成の戦略2021
    • Author(s)
      横尾英知、出水庸介
    • Journal Title

      細胞

      Volume: 53 Pages: 148-151

    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Journal Article] Helical Antimicrobial Peptide Foldamers Containing Non‐proteinogenic Amino Acids2021
    • Author(s)
      Yokoo Hidetomo、Hirano Motoharu、Misawa Takashi、Demizu Yosuke
    • Journal Title

      ChemMedChem

      Volume: 16 Pages: 1226-1233

    • DOI

      10.1002/cmdc.202000940

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K22711, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880

  • [Journal Article] Critical role of mitochondrial ubiquitination and the OPTN-ATG9A axis in mitophagy.2020
    • Author(s)
      Yamano Koji、Kikuchi Reika、Kojima Waka、Hayashida Ryota、Koyano Fumika、Kawawaki Junko、Shoda Takuji、Demizu Yosuke、Naito Mikihiko、Tanaka Keiji、Matsuda Noriyuki
    • Journal Title

      J. Cell Biol.

      Volume: 219 Pages: 1-1

    • DOI

      10.1083/jcb.201912144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05500, KAKENHI-PLANNED-18H05502, KAKENHI-PLANNED-19H05712, KAKENHI-PROJECT-19H00997, KAKENHI-PROJECT-18K06237

  • [Journal Article] Temperature-Dependent Formation of <i>N</i>-Nitrosodimethylamine during the Storage of Ranitidine Reagent Powders and Tablets2020
    • Author(s)
      Abe Yasuhiro、Yamamoto Eiichi、Yoshida Hiroyuki、Usui Akiko、Tomita Naomi、Kanno Hitomi、Masada Sayaka、Yokoo Hidetomo、Tsuji Genichiro、Uchiyama Nahoko、Hakamatsuka Takashi、Demizu Yosuke、Izutsu Ken-ichi、Goda Yukihiro、Okuda Haruhiro
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 68 Issue: 10 Pages: 1008-1012

    • DOI

      10.1248/cpb.c20-00431

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Journal Article] Design and synthesis of peptide-based chimeric molecules to induce degradation of the estrogen and androgen receptors.2020
    • Author(s)
      Yokoo Hidetomo、Ohoka Nobumichi、Naito Mikihiko、Demizu Yosuke
    • Journal Title

      Bioorg Med Chem.

      Volume: 28 Pages: 115595-115595

    • DOI

      10.1016/j.bmc.2020.115595

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PLANNED-18H05502

  • [Journal Article] De Novo Design of Cell‐Penetrating Foldamers2020
    • Author(s)
      Yokoo Hidetomo、Misawa Takashi、Demizu Yosuke
    • Journal Title

      The Chemical Record

      Volume: 20 Pages: 912-921

    • DOI

      10.1002/tcr.202000047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18K14880

  • [Journal Article] Selective Degradation of Target Proteins by Chimeric Small-Molecular Drugs, PROTACs and SNIPERs2020
    • Author(s)
      Ishikawa Minoru、Tomoshige Shusuke、Demizu Yosuke、Naito Mikihiko
    • Journal Title

      Pharmaceuticals

      Volume: 13 Pages: 74-74

    • DOI

      10.3390/ph13040074

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K16326, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-18H02551

  • [Journal Article] Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety2020
    • Author(s)
      Shoda T, Ohoka N, Tsuji G, Fujisato T, Inoue H, Demizu Y, Naito M, Kurihara M.
    • Journal Title

      Pharmaceuticals

      Volume: 13 Pages: 34-34

    • DOI

      10.3390/ph13030034

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-PLANNED-18H05502

  • [Journal Article] Synthesis of Chiral α‐Trifluoromethyl α,α‐Disubstituted α‐Amino Acids and Conformational Analysis of L‐Leu‐Based Peptides with (R)‐ or (S)‐α‐Trifluoromethylalanine2020
    • Author(s)
      Ueda Atsushi、Ikeda Misuzu、Kasae Takuya、Doi Mitsunobu、Demizu Yosuke、Oba Makoto、Tanaka Masakazu
    • Journal Title

      ChemistrySelect

      Volume: 5 Pages: 10882-10882

    • DOI

      10.1002/slct.202002888

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K06967, KAKENHI-PROJECT-17K19495, KAKENHI-PROJECT-18K14870

  • [Journal Article] Development of Photoswitchable Estrogen Receptor Ligands2020
    • Author(s)
      K. Tsuchiya, T. Umeno, G. Tsuji, H. Yokoo, M. Tanaka, K. Fukuhara, Y. Demizu, T. Misawa
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 68 Issue: 4 Pages: 398-402

    • DOI

      10.1248/cpb.c19-01108

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K06588, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385

  • [Journal Article] Design, synthesis, and biological activity of conformationally restricted analogues of silibinin2020
    • Author(s)
      Mizuno Mirei、Mori Kazunori、Tsuchiya Keisuke、Takaki Takashi、Misawa Takashi、Demizu Yosuke、Shibanuma Motoko、Fukuhara Kiyoshi
    • Journal Title

      ACS Omega

      Volume: 5 Pages: 23164-23174

    • DOI

      10.1021/acsomega.0c02936

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K15486, KAKENHI-PROJECT-18K06588

  • [Journal Article] Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.2020
    • Author(s)
      Shibata Norihito、Ohoka Nobumichi、Tsuji Genichiro、Demizu Yosuke、Miyawaza Keiji、Ui-Tei Kumiko、Akiyama Tetsu、Naito Mikihiko
    • Journal Title

      Oncogene

      Volume: - Pages: 3867-3878

    • DOI

      10.1038/s41388-020-1253-0

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K07311, KAKENHI-PLANNED-17H06325, KAKENHI-PROJECT-17H01537, KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502

  • [Journal Article] Rational Design of Helix‐Stabilized Antimicrobial Peptide Foldamers Containing α,α‐Disubstituted Amino Acids or Side‐Chain Stapling2020
    • Author(s)
      Hirano Motoharu、Saito Chihiro、Goto Chihiro、Yokoo Hidetomo、Kawano Ryuji、Misawa Takashi、Demizu Yosuke
    • Journal Title

      ChemPlusChem

      Volume: 85 Pages: 2731-2736

    • DOI

      10.1002/cplu.202000749

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-20K22711, KAKENHI-PROJECT-18K14880

  • [Journal Article] Facile Synthesis of Kwakhurin, a Marker Compound of <i>Pueraria mirifica</i> and Its Quantitative NMR Analysis for Standardization as a Reagent2020
    • Author(s)
      Tsuji Genichiro、Yusa Masaaki、Masada Sayaka、Yokoo Hidetomo、Hosoe Junko、Hakamatsuka Takashi、Demizu Yosuke、Uchiyama Nahoko
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 68 Issue: 8 Pages: 797-801

    • DOI

      10.1248/cpb.c20-00346

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Journal Article] Copper‐Catalyzed Enantioselective Synthesis of Oxazolines from Aminotriols via Asymmetric Desymmetrization2020
    • Author(s)
      Yamamoto Kosuke、Tsuda Yutaro、Kuriyama Masami、Demizu Yosuke、Onomura Osamu
    • Journal Title

      Chemistry - An Asian Journal

      Volume: 15 Pages: 840-844

    • DOI

      10.1002/asia.201901742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19K05459, KAKENHI-PROJECT-19K16317, KAKENHI-PROJECT-17K08385

  • [Journal Article] Design and Synthesis of 4-(2-Pyrrolyl)-4-phenylheptane Derivatives as Estrogen Receptor Antagonists2020
    • Author(s)
      Tsuji Genichiro、Demizu Yosuke、Naganuma Miyako、Yokoo Hidetomo、Misawa Takashi、Matsuno Kenji
    • Journal Title

      HETEROCYCLES

      Volume: 101 Pages: 429-429

    • DOI

      10.3987/com-19-14121

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17K08371

  • [Journal Article] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2020
    • Author(s)
      Shun-suke Moriya, Yuko Sasa, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, and Toru Sugiyama
    • Journal Title

      Peptide Science

      Volume: 2019 Pages: 173-174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Journal Article] Development of Amphipathic Antimicrobial Peptide Foldamers Based on Magainin 2 Sequence2019
    • Author(s)
      C. Goto, M. Hirano, K. Hayashi, Y. Kikuchi, Y. Hara-Kudo, T. Misawa,* Y. Demizu*
    • Journal Title

      ChemMedChem

      Volume: 14 Pages: 1911-1916

    • DOI

      10.1002/cmdc.201900460

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PLANNED-18H05502

  • [Journal Article] PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine2019
    • Author(s)
      Toru Sugiyama, Hatsune Shibasaki, Shun-suke Moriya, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
    • Journal Title

      Peptide Science

      Volume: 2018 Pages: 44-44

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Journal Article] Rapid and efficient high-performance liquid chromatography analysis of N-nitrosodimethylamine impurity in valsartan drug substance and its medicines2019
    • Author(s)
      S. Masada, G. Tsuji, R. Arai, N. Uchiyama,* Y. Demizu,* T. Tsutsumi, Y. Abe, H. Akiyama, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda
    • Journal Title

      Sci. Rep.

      Volume: 9 Pages: 11852-11852

    • DOI

      10.1038/s41598-019-48344-5

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Journal Article] Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides2019
    • Author(s)
      M. Kuriyama,* G. Yano, H. Kiba, T. Morimoto, K. Yamamoto, Y. Demizu, O. Onomura*
    • Journal Title

      Organic Process Research & Development

      Volume: 23 Pages: 1552-1557

    • DOI

      10.1021/acs.oprd.9b00193

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06582, KAKENHI-PROJECT-19K05459

  • [Journal Article] Inhibition of β-amyloid induced neurotoxicity by planar analogues of procyanidin B32019
    • Author(s)
      M. Mizuno, K. Mori, T. Misawa, Y. Demizu, M. Shibanuma, K. Fukuhara*
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Pages: 2659-2663

    • DOI

      10.1016/j.bmcl.2019.07.038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06588, KAKENHI-PROJECT-19K07423

  • [Journal Article] Facile synthesis of alpha-exo-methylene ketones from alpha,alpha-disubstituted allyl alcohols by electrochemical oxidative migration2019
    • Author(s)
      Yamamoto, K.; Kikuchi, N.; Hamamizu, T.; Yoshimatsu, H.; Kuriyama, M.; Demizu, Y.; Onomura, O.
    • Journal Title

      ChemElectroChem

      Volume: 印刷中 Pages: 4169-4172

    • DOI

      10.1002/celc.201900172

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08167, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-19K05459

  • [Journal Article] Refining Calibration Procedures of Circular Dichroism Spectrometer to Improve Usability2019
    • Author(s)
      K. Sakai-Kato,* K. Yoshida, T. Ohgita, Y. Takechi-Haraya, Y. Demizu, H. Saito
    • Journal Title

      Analytical Sciences

      Volume: 35 Issue: 11 Pages: 1275-1278

    • DOI

      10.2116/analsci.19n022

      10.2116/analsci.19N022

    • NAID

      130007680293

    • ISSN
      0910-6340, 1348-2246
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17H03979

  • [Journal Article] Development of Small Molecule Chimeras That Recruit AhR E3 Ligase to Target Proteins.2019
    • Author(s)
      N. Ohoka, G. Tsuji, T. Shoda, T. Fujisato, M. Kurihara, Y. Demizu, M. Naito*
    • Journal Title

      ACS Chemical Biology

      Volume: 14 Pages: 2822-2832

    • DOI

      10.1021/acschembio.9b00704

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-19K07009, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16K08340

  • [Journal Article] Rational design of novel amphipathic antimicrobial peptides focused on distribution of cationic amino acid residues2019
    • Author(s)
      Misawa T, Goto C, Shibata N, Hirano M, Kikuchi Y, Naito M, Demizu Y
    • Journal Title

      MedChemComm

      Volume: 印刷中 Pages: 896-900

    • DOI

      10.1039/c9md00166b

    • Peer Reviewed
    • Data Source
      KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-17K08385

  • [Journal Article] Development of 2-aminoisobutyric acid (Aib)-rich cell-penetrating foldamers for efficient siRNA delivery2019
    • Author(s)
      T. Misawa,* N. Ohoka,* M. Oba, H. Yamashita, M. Tanaka, M. Naito, Y. Demizu*
    • Journal Title

      Chemical Communications

      Volume: 55 Pages: 7792-7795

    • DOI

      10.1039/c9cc02203a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502

  • [Journal Article] Analysis of an Impurity, <i>N</i>-Nitrosodimethylamine, in Valsartan Drug Substances and Associated Products Using GC-MS2019
    • Author(s)
      T. Tsutsumi, H. Akiyama,* Y. Demizu, N. Uchiyama, S. Masada, G. Tsuji, R. Arai, Y. Abe, Y. Haraya, T. Hakamatsuka, K. Izutsu, Y. Goda, H. Okuda
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 42 Issue: 4 Pages: 547-551

    • DOI

      10.1248/bpb.b19-00006

    • NAID

      130007622070

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Journal Article] The extent of helical induction caused by introducing a-aminoisobutyric acid into an oligovaline sequence2018
    • Author(s)
      G. Tsuji, T. Misawa, M. Doi, Y. Demizu*
    • Journal Title

      ACS Omega

      Volume: 3 Pages: 6395-6399

    • DOI

      10.1021/acsomega.8b01030

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880

  • [Journal Article] Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives2018
    • Author(s)
      H. Kobayashi, T. Misawa,* M. Oba, N. Hirata, Y. Kanda, M. Tanaka, K. Matsuno, Y. Demizu*
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 66 Issue: 5 Pages: 575-580

    • DOI

      10.1248/cpb.c18-00079

    • NAID

      130006729546

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14880, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-17K19503

  • [Journal Article] Development of a Small Hybrid Molecule That Mediates Degradation of His-Tag Fused Proteins2018
    • Author(s)
      K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
    • Journal Title

      . Med. Chem.

      Volume: 61 Pages: 576-582

    • DOI

      10.1021/acs.jmedchem.7b00413

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385

  • [Journal Article] Design and synthesis of estrogen receptor ligands with a 4-heterocycle-4-phenylheptane skeleton.2018
    • Author(s)
      Eto Ryo、Misawa Takashi、Noguchi-Yachide Tomomi、Ohoka Nobumichi、Kurihara Masaaki、Naito Mikihiko、Tanaka Masakazu、Demizu Yosuke
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Pages: 1638-1642

    • DOI

      10.1016/j.bmc.2018.02.010

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16J03592, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K06570

  • [Journal Article] Design and synthesis of cell-permeable fluorescent nitrilotriacetic acid derivatives2018
    • Author(s)
      Tsuji G, Hattori T, Kato M, Hakamata W, Inoue H, Naito M, Kurihara M, Demizu Y, Shoda T.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Pages: 5494-5498

    • DOI

      10.1016/j.bmc.2018.09.028

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385

  • [Journal Article] Left-Handed Helix of Three-Membered Ring Amino Acid Homopeptide Interrupted by an N-H・・・Ethereal O-Type Hydrogen Bond2018
    • Author(s)
      Y. Koba, A. Ueda, M. Oba, M. Doi, T. Kato, Y. Demizu, M. Tanaka*
    • Journal Title

      Organic Letters

      Volume: 20 Pages: 7830-7834

    • DOI

      10.1021/acs.orglett.8b03331

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-18K14870, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17H07269, KAKENHI-PROJECT-16K18847

  • [Journal Article] Structural development of non-secosteroidal vitamin D receptor (VDR) ligands without any asymmetric carbon2018
    • Author(s)
      Misawa T, Tsuji G, Takahashi T, Ochiai E, Takagi KI, Horie K, Kakuda S, Takimoto-Kamimura M, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 26 Pages: 6146-6152

    • DOI

      10.1016/j.bmc.2018.11.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385

  • [Journal Article] Diastereomeric Right- and Left-Handed Helical Structures with Fourteen (R)-Chiral Centers2017
    • Author(s)
      R. Eto, M. Oba, A. Ueda, T. Uku, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Chemistry - A European Journal

      Volume: 23 Pages: 18120-18124

    • DOI

      10.1002/chem.201705306

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16K18847, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-16J03592, KAKENHI-PROJECT-26460169

  • [Journal Article] PNA monomers fully compatible with standard Fmoc-based solid-phase synthesis of pseudocomplementary PNA2017
    • Author(s)
      Toru Sugiyama, Genki Hasegawa, Chie Niikura, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 (15) Pages: 3337-3341

    • DOI

      10.1016/j.bmcl.2017.06.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169

  • [Journal Article] Rational Design and Synthesis of Post-Functionalizable Peptide Foldamers as Helical Templates.2017
    • Author(s)
      T. Misawa,* Y. Kanda, Y. Demizu*
    • Journal Title

      Bioconjugate Chemistry

      Volume: 28 Pages: 3029-3035

    • DOI

      10.1021/acs.bioconjchem.7b00621

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17K19503, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-17H04107, KAKENHI-PROJECT-26460169

  • [Journal Article] Development of an ON/OFF switchable fluorescent probe targeting His tag fused proteins in living cells2017
    • Author(s)
      Okitsu K, Misawa T, Shoda T, Kurihara M, Demizu Y.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 27 Pages: 3417-3422

    • DOI

      10.1016/j.bmcl.2017.05.087

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169

  • [Journal Article] Low pH-triggering changes in peptide secondary structures2017
    • Author(s)
      K. Furukawa, M. Oba,* K. Toyama, G. O. Opiyo, Y. Demizu, M. Kurihara, M. Doi, M. Tanaka*
    • Journal Title

      Organic & Biomolecular Chemistry

      Volume: 15 Pages: 6302-6305

    • DOI

      10.1039/c7ob01374d

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-17J03086, KAKENHI-PROJECT-26460169

  • [Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide2017
    • Author(s)
      T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Pages: 4478-4481

    • DOI

      10.1016/j.bmcl.2017.08.001

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121

  • [Journal Article] Development of helix-stabilized cell-penetrating peptides containing cationic alpha,alpha-disubstituted amino acids as helical promoters2017
    • Author(s)
      Yamashita H, Misawa T, Oba M, Tanaka M, Naito M, Kurihara M, Demizu Y.
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 25(6) Pages: 1846-1851

    • DOI

      10.1016/j.bmc.2017.01.044

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26290055, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121

  • [Journal Article] Efficient synthesis of a multi-substituted diphenylmethane skeleton as a steroid mimetic2017
    • Author(s)
      takashi misawa, katsuya tanaka, yosuke demizu, masaaki kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 印刷中 Pages: 2590-2593

    • DOI

      10.1016/j.bmcl.2017.03.066

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169

  • [Journal Article] Preorganized cyclic alpha,alpha-disubstituted alpha-amino acids bearing functionalized side chains that act as peptide-helix inducers2017
    • Author(s)
      H. Kobayashi, T. Misawa, K. Matsuno, Y. Demizu*
    • Journal Title

      J. Org. Chem.

      Volume: 82 Pages: 10722-10726

    • DOI

      10.1021/acs.joc.7b01946

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169

  • [Journal Article] Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton2017
    • Author(s)
      T. Misawa, T. Fujisato, Y. Kanda, N. Ohoka, T. Shoda, M. Yorioka, M. Makishima, Y. Sekino, M. Naito, Y. Demizu, Masaaki Kurihara
    • Journal Title

      MedChemComm

      Volume: 8 Pages: 239-246

    • DOI

      10.1039/c6md00553e

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-26460169

  • [Journal Article] Tamoxifen and fulvestrant hybrids showed potency as selective estrogen receptor down-regulators.2017
    • Author(s)
      Takuji Shoda, Masashi Kato, Takuma Fujisato, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Med. Chem. (Bentham)

      Volume: 13 Pages: 206-213

    • DOI

      10.2174/1573406412666160805101408

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-26460169

  • [Journal Article] Helical l-Leu-Based Peptides Having Chiral Five-Membered Carbocyclic Ring Amino Acids with an Ethylene Acetal Moiety2017
    • Author(s)
      Y. Koba, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      ChemistrySelect

      Volume: 2 Pages: 8108-8114

    • DOI

      10.1002/slct.201700832

    • NAID

      120006484354

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16K18847, KAKENHI-PROJECT-17H03998, KAKENHI-PROJECT-26460169

  • [Journal Article] Development of a peptide-based inducer of protein degradation targeting NOTCH12017
    • Author(s)
      Ohoka N, Misawa T, Kurihara M, Demizu Y, Naito M.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 27 Pages: 4985-4988

    • DOI

      10.1016/j.bmcl.2017.10.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121

  • [Journal Article] Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules2017
    • Author(s)
      Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
    • Journal Title

      Mol Pharmacol

      Volume: 91 Pages: 159-166

    • DOI

      10.1124/mol.116.105569

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979

  • [Journal Article] Development of helix-stabilized antimicrobial peptides composed of lysine and hydrophobic a,a-disubstituted 1-amino acid resides2017
    • Author(s)
      T. Misawa, M. Imamura, Y. Ozawa, K. Haishima, M. Kurihara, Y. Kikuchi,* Y. Demizu*
    • Journal Title

      Bioorganic Medicinal chemistry letter

      Volume: 27 Pages: 3950-3953

    • DOI

      10.1016/j.bmcl.2017.07.074

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26460169

  • [Journal Article] alpha-Helical structures of oligopeptides with alternating L-Leu-Aib segment2016
    • Author(s)
      Y. Demizu,* K. Okitsu, H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      Eur. J. Org. Chem.

      Volume: XX Pages: 2815-2820

    • DOI

      10.1002/ejoc.201600327

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator.2016
    • Author(s)
      Akiyama N, Takizawa N, Miyauchi M, Yanai H, Tateishi R, Shinzawa M, Yoshinaga R, Kurihara M, Demizu Y, Yasuda H, Yagi S, Wu G, Matsumoto M, Sakamoto R, Yoshida N, Penninger JM, Kobayashi Y, Inoue J, Akiyama T.
    • Journal Title

      J Exp Med

      Volume: 213 Pages: 1441-1458

    • DOI

      10.1084/jem.20151780

    • NAID

      120006532434

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01150, KAKENHI-PUBLICLY-15H01176, KAKENHI-ORGANIZER-15H05935, KAKENHI-PUBLICLY-16H01631, KAKENHI-ORGANIZER-16H06495, KAKENHI-PLANNED-16H06496, KAKENHI-PLANNED-16H06575, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-16H02691, KAKENHI-PROJECT-16H05342, KAKENHI-PROJECT-26460169, KAKENHI-INTERNATIONAL-16K21731, KAKENHI-PROJECT-16H06276

  • [Journal Article] Syntheses of chiral five-membered ring amino acids with an acetal moiety and helical conformations of its homo-chiral homopeptides2016
    • Author(s)
      Y. Koba, Y. Hirata, A. Ueda, M. Oba, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka
    • Journal Title

      Biopolymers (Pept. Sci.)

      Volume: 印刷中 Pages: 555-562

    • DOI

      10.1002/bip.22769

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169

  • [Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.2016
    • Author(s)
      K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
    • Journal Title

      Methods Mol Biol

      Volume: 1366 Pages: 549-560

    • DOI

      10.1007/978-1-4939-3127-9_42

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090

  • [Journal Article] Handedness preferences of heterochiral helical peptides containing homochiral peptide segments2016
    • Author(s)
      Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      Eur. J. Org. Chem.

      Volume: 4 Pages: 840-846

    • DOI

      10.1002/ejoc.201501146

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Synthesis and evaluation of raloxifene derivatives as a selective estrogen receptor down-regulator.2016
    • Author(s)
      T. Kato, H. Yamashita, T. Misawa, K. Nishida, M. Kurihara, M. Tanaka, Y. Demizu, M. Oba
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 24 Pages: 2681-2687

    • DOI

      10.1016/j.bmc.2016.04.031

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169

  • [Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand2016
    • Author(s)
      Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 26 Pages: 1865-4869

    • DOI

      10.1016/j.bmcl.2016.09.041

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916

  • [Journal Article] A helix-stabilized cell-penetrating peptide as an intracellular-delivery tool2016
    • Author(s)
      Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
    • Journal Title

      chembiochem

      Volume: 17 Pages: 137-140

    • DOI

      10.1002/cbic.201500468

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905

  • [Journal Article] Helical structures of homo-chiral isotope-labeled α-aminoisobutyric acid peptides2016
    • Author(s)
      A. Ueda, M. Oba, Y. Izumi, Y. Sueyoshi, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Tetrahedron

      Volume: 39 Pages: 5864-5871

    • DOI

      10.1016/j.tet.2016.08.011

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K18847

  • [Journal Article] Development of a peptide-based inducer of nuclear receptors degradation2016
    • Author(s)
      Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Pages: 2655-2658

    • DOI

      10.1016/j.bmcl.2016.04.013

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121

  • [Journal Article] Development of a cell-penetrating peptide that exhibits responsive changes in its secondary structure in the cellular environment2016
    • Author(s)
      H. Yamashita, T. Kato, M. Oba, T. Misawa, T. Hattori, N. Ohoka, M. Tanaka, M. Naito, M. Kurihara, Y. Demizu
    • Journal Title

      Sci. Rep.

      Volume: 6 Pages: 33003-33003

    • DOI

      10.1038/srep33003

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15J05945, KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169

  • [Journal Article] Influence of L-Leu to D-Leu replacement on the helical secondary structures of L-Leu-Aib-based dodecapeptides2016
    • Author(s)
      Y. Demizu,* K. Okitsu, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      ChemistrySelect

      Volume: 1 Pages: 5805-5811

    • DOI

      10.1002/slct.201601493

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Peptide Nucleic Acid with a Lysine Side Chain at the β-Position: Synthesis and Application for DNA Cleavage2016
    • Author(s)
      Toru Sugiyama, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Masashi Takano, and Atsushi Kittaka
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 64 Issue: 7 Pages: 2255-2268

    • DOI

      10.1248/cpb.c16-00191

    • NAID

      130005160035

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15H04349, KAKENHI-PROJECT-26650033

  • [Journal Article] Design and synthesis of novel selective estrogen receptor degradation inducers based on diphenylheptane skeleton2016
    • Author(s)
      Takuji Shoda, Masashi Kato, Takuma Fujisato, Takashi Misawa, Yosuke Demizu, Hideshi Inoue, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      MedChemComm

      Volume: 24 Pages: 239-246

    • DOI

      10.1016/j.bmc.2016.04.068

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K18916

  • [Journal Article] The side-chain hydroxy groups of a cyclic alpha,alpha-disubstituted alpha-amino acid promote oligopeptide helix packing in the crystalline state2016
    • Author(s)
      Y. Demizu,* M. Doi, H. Yamashita, T. Misawa, M. Oba, M. Kurihara, H. Suemune, M. Tanaka
    • Journal Title

      Biopolymers (Pept. Sci.)

      Volume: 106 Pages: 757-768

    • DOI

      10.1002/bip.22881

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] A synthetic cannabinoid FDU-NNEI, two 2H-indazole isomers of synthetic cannabinoids AB-CHMINACA and NNEI indazole analog (MN-18), a phenethylamine derivative N-OH-EDMA, and a cathinone derivative dimethoxy-α-PHP, newly identified in illegal products2015
    • Author(s)
      N. Uchiyama,* Y. Shimokawa, R. Kikura-Hanajiri, Y. Demizu, Y. Goda, T. Hakamatsuka
    • Journal Title

      Forensic Toxicol.

      Volume: 33 Pages: 244-259

    • DOI

      10.1007/s11419-015-0268-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Design, synthesis and anti-HIV-1 activity of 1-aromatic methyl-substituted 3-(3,5-dimethylbenzyl)uracil and N-3,5-dimethylbenzyl-substituted urea derivatives2015
    • Author(s)
      N. Sakakibara,* M. Baba, M. Okamoto, M. Toyama, Y. Demizu, T. Misawa, M. Kurihara, K. Irie, Y. Kato, T. Maruyama
    • Journal Title

      Antiviral Chem. Chemother.

      Volume: 24 Pages: 3-18

    • DOI

      10.1177/2040206614566584

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化2015
    • Author(s)
      出水庸介*，三澤隆史，栗原正明*
    • Journal Title

      有機合成化学協会誌

      Volume: 72 Pages: 1336-1359

    • NAID

      130004749130

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Synthesis of a bis-cationic α,α-disubstituted amino acid (9-amino-bispidine-9-carboxylic acid) and its effects on the conformational properties of peptides2015
    • Author(s)
      H. Yamashita, Y. Demizu,* T. Misawa, T. Shoda, M. Kurihara*
    • Journal Title

      Tetrahedron

      Volume: 71 Pages: 2241-2245

    • DOI

      10.1016/j.tet.2015.02.076

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085

  • [Journal Article] Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.2015
    • Author(s)
      T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*
    • Journal Title

      Bioorg Med Chem.

      Volume: 23 Pages: 3091-3096

    • DOI

      10.1016/j.bmc.2015.05.002

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-25430164

  • [Journal Article] Synthesis and Evaluation of Novel Carbocyclic Oxetanocin A (COA-Cl) Derivatives as Potential Tube Formation Agents2015
    • Author(s)
      N. Sakakibara,* J. Igarashi, M. Takata, Y. Demizu, T. Misawa, M. Kurihara, R. Konishi, Y. Kato, T. Maruyama, I. Tsukamoto
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 63 Issue: 9 Pages: 701-709

    • DOI

      10.1248/cpb.c15-00386

    • NAID

      130005096030

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25461132

  • [Journal Article] Effects of D-Leu Residues on the Helical Secondary Structures of L-Leu-Based Nonapeptides2015
    • Author(s)
      Y. Demizu,* H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara*
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 63 Issue: 3 Pages: 218-224

    • DOI

      10.1248/cpb.c14-00760

    • NAID

      130004803775

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Synthesis and Resolution of Substituted [5]Carbohelicenes2015
    • Author(s)
      K. Usui,* K. Yamamoto, T. Shimizu, M. Biao, M. Okazumi, Y. Demizu, M. Kurihara, H. Suemune*
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 80 Pages: 6502-6508

    • DOI

      10.1021/acs.joc.5b00759

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-14J03777, KAKENHI-PROJECT-25410096

  • [Journal Article] Plasmid DNA delivery using fluorescein-labeled arginine-rich peptides.2015
    • Author(s)
      M. Oba,* Y. Demizu, H. Yamashita, M. Kurihara, M. Tanaka
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 23 Pages: 4911-4918

    • DOI

      10.1016/j.bmc.2015.05.025

    • NAID

      120005646371

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25713008

  • [Journal Article] Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.2015
    • Author(s)
      Takashi Misawa, Momoko Yorioka, Yosuke Demizu, Tomomi Noguchi-Yachide, Nobumichi Ohoka, Megumi Kurashima-Kinoshita, Hitomi Motoyoshi, Hisao Nojiri, Atsushi Kittaka, Makoto Makishima, Mikihiko Naito, Masaaki Kurihara
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 25 Pages: 5362-5366

    • DOI

      10.1016/j.bmcl.2015.09.030

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K07869, KAKENHI-PROJECT-15K08015, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905, KAKENHI-PROJECT-26860049

  • [Journal Article] Amino equatorial effect of a six-membered ring amino acid on its peptide 310- and α-helices2015
    • Author(s)
      Takayuki Hirata, Atsushi Ueda, Makoto Oba, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Masanobu Nagano, Hiroshi Suemune, Masakazu Tanaka
    • Journal Title

      Tetrahedron

      Volume: 71 Pages: 2409-2420

    • DOI

      10.1016/j.tet.2015.02.075

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J03534, KAKENHI-PROJECT-25410096, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169

  • [Journal Article] A preorganized β-amino acid bearing a guanidinium side chain and its use in cell-penetrating peptides2015
    • Author(s)
      Y. Demizu,* M. Oba, K. Okitsu, H. Yamashita, T. Misawa, M. Doi, M. Tanaka, M. Kurihara, S. H. Gellman
    • Journal Title

      Org. Biomol. Chem.

      Volume: 13 Pages: 5617-5620

    • DOI

      10.1039/c5ob00389j

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives2015
    • Author(s)
      N. Sakakibara,* G. Balboni, C. Congiu, V. Onnis, Y. Demizu, T. Misawa, M. Kurihara, Y. Kato, T. Maruyama, M. Toyama, M. Okamoto, M. Baba
    • Journal Title

      Antiviral Chem. Chemother.

      Volume: 24 Pages: 62-71

    • DOI

      10.1177/2040206615612208

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Peptide foldamers composed of six-membered ring alpha,alpha-disubstituted alpha-amino acids with two changeable chiral acetal moieties2015
    • Author(s)
      K. Tanda, R. Eto, K. Kato, M. Oba, A. Ueda, H. Suemune, M. Doi, Y. Demizu, M. Kurihara, M. Tanaka*
    • Journal Title

      Tetrahedron

      Volume: 71 Pages: 3909-3914

    • DOI

      10.1016/j.tet.2015.04.031

    • NAID

      120005615572

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PUBLICLY-26105745

  • [Journal Article] Topological Study of the Structures of Heterochiral Peptides Containing Equal Amounts of L-Leu and D-Leu.2015
    • Author(s)
      Y. Demizu,* H. Yamashita, M. Doi, T. Misawa, M. Oba, M. Tanaka, M. Kurihara*
    • Journal Title

      European Journal of Organic chemistry

      Volume: 80 Pages: 8597-8603

    • DOI

      10.1021/acs.joc.5b01541

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905

  • [Journal Article] Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.2015
    • Author(s)
      Y. Demizu*, T. Misawa, T. Nagakubo, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 23 Pages: 4132-4138

    • DOI

      10.1016/j.bmc.2015.06.067

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26670041

  • [Journal Article] 12.Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015
    • Author(s)
      T. Misawa, Y. Demizu, M. Kawamura, N. Yamagata, M. Kurihara.
    • Journal Title

      Bioorg. Med. Chem.

      Volume: 23 Pages: 1055-1061

    • DOI

      10.1016/j.bmc.2015.01.007

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25893038, KAKENHI-PROJECT-26460169

  • [Journal Article] 短鎖ペプチドのヘリカル構造制御と機能化2014
    • Author(s)
      出水庸介*
    • Journal Title

      ペプチドニュースレター

      Volume: 94 Pages: 3-7

    • NAID

      130004749130

    • Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator2014
    • Author(s)
      Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 87-89

    • DOI

      10.1016/j.bmcl.2013.11.078

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085

  • [Journal Article] NAD-dependent isocitrate dehydrogenase as a novel target of tributyltin in human embryonic carcinoma cells2014
    • Author(s)
      Yamada S, Kotake Y, Demizu Y, Kurihara M, Sekino Y, Kanda Y.
    • Journal Title

      Sci. Rep.

      Volume: 4 Pages: 5952-5952

    • DOI

      10.1038/srep05952

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24406004, KAKENHI-PROJECT-26460169

  • [Journal Article] Conformational studies on peptides having chiral five-membered ring amino acid with two azido or triazole functional groups within the sequence of Aib residues.2014
    • Author(s)
      Makoto Oba, Naomi Kawabe, Hiroomi Takazaki, Yosuke Demizu, Mitsunobu Doi, Masaaki Kurihara, Hiroshi Suemune, Masakazu Tanaka
    • Journal Title

      Tetrahedron

      Volume: 70 Pages: 8900-8907

    • DOI

      10.1016/j.tet.2014.09.086

    • NAID

      120005572525

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169

  • [Journal Article] Amphipathic short helix-stabilized peptides with cell-membrane penetration2014
    • Author(s)
      Hiroko Yamashita, Yosuke Demizu, Takuji Shoda, Yukiko Sato, Makoto Oba, Masakazu Tanaka, Masaaki Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 22 Pages: 2403-2408

    • DOI

      10.1016/j.bmc.2014.03.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25713008, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085

  • [Journal Article] Isoheleproline: a new amino acid-sesquiterpene adduct from Inula helenium2014
    • Author(s)
      K. Zaima, D. Wakana, Y. Demizu, Y. Kumeta, H. Kamakura, T. Maruyama, M. Kurihara, Y. Goda*
    • Journal Title

      J. Nat. Med.

      Volume: 68 Pages: 432-435

    • DOI

      10.1007/s11418-013-0806-8

    • NAID

      40020023355

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Journal Article] Helical Peptide-Floldamers Having a Chiral Five-Membered Ring Amino Acid with Two Azido Functional Groups2014
    • Author(s)
      Makoto Oba, Hiroomi Takazaki, Naomi Kawabe, Mitsunobu Doi, Yosuke Demizu, Masaaki Kurihara, Hiromu Kawakubo, Masanobu Nagano, Hiroshi Suemune, and Masakazu Tanaka
    • Journal Title

      J. Org. Chem.

      Volume: 79 Pages: 9125-9140

    • DOI

      10.1021/jo501493x

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-13J03534, KAKENHI-PROJECT-25410096, KAKENHI-PROJECT-25713008, KAKENHI-PUBLICLY-26105745, KAKENHI-PROJECT-26460169

  • [Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription2014
    • Author(s)
      2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
    • Journal Title

      Bioconjugate Chem.

      Volume: 25 Pages: 1921-1924

    • DOI

      10.1021/bc500480e

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085

  • [Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013
    • Author(s)
      Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
    • Journal Title

      Cancer Sci.

      Volume: 104 Pages: 1492-1498

    • DOI

      10.1111/cas.12272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084

  • [Journal Article]2013
    • Author(s)
      Y. Demizu, S. Nagoya, M. Shirakawa, M. Kawamura, N. Yamagata, Y. Sato, M. Doi, M. Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 23

    • URL

      http://www.sciencedirect.com/science/article/pii/S0960894X13007099

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] One-Handed Helical Screw Direction of Homopeptide Foldamer Exclusively Induced by Cyclic α-Amino Acid Side-Chain Chiral Centers2012
    • Author(s)
      Y.Demizu
    • Journal Title

      Chem.Eur.J.

      Volume: 18 Pages: 2430-2439

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
    • Author(s)
      Y.Demizu
    • Journal Title

      Bioorg.Med.Chem.Lett

      Volume: 22 Pages: 1793-1796

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Twisted Structure of a Cyclic Hexapeptide Containing a Combination of Alternating L-Leu-D-Leu- Aib Segments2012
    • Author(s)
      Demizu, Y., Nagoya, S., Doi, M., Sato, Y., Tanaka, M., Kurihara, M
    • Journal Title

      J. Org. Chem

      Volume: 77 Pages: 9361-9365

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Conformations of helical Aib peptides containinga pair of L-amino acid and D-amino acid2012
    • Author(s)
      Y. Demizu, Y. Yabuki, M. Doi, Y. Sato,M. Tanaka, M. Kurihara
    • Journal Title

      J. Pept. Sci

      Volume: 18 Pages: 466-475

    • DOI

      10.1002/psc.2418

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Solid-phase nucleophilic fluorination2012
    • Author(s)
      Y. Demizu
    • Journal Title

      Synth. Commun.

      Volume: 42 Pages: 1724-1730

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy2012
    • Author(s)
      Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
    • Journal Title

      Bioorg. Med. Chem. Lett

      Volume: 22 Pages: 1793-1796

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Identification of Mutaprodenafil in a Dietary Supplement and its Subsequent Synthesis2011
    • Author(s)
      Y.Demizu
    • Journal Title

      Chem.Pharm.Bull.

      Volume: 59 Pages: 1314-1316

    • NAID

      130001087104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor2011
    • Author(s)
      Demizu, Y.
    • Journal Title

      Lett.Org.Chem

      Volume: 8 Pages: 43-47

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Effect of one D-Leu residue on right-handed helical-L-Leu-Aib-peptides in the crystal state2011
    • Author(s)
      Y.Demizu
    • Journal Title

      J.Pept.Sci.

      Volume: 17 Pages: 420-426

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor2011
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      Lett.Org.Chem.

      Volume: 8 Pages: 43-47

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Effect of one D-Leu residue on right-handed helical -L-Leu-Aibpeptides in the crystal state2011
    • Author(s)
      Y. Demizu, M. Doi, Y. Sato, M. Tanaka, H. Okuda, M. Kurihara
    • Journal Title

      J. Pept. Sci

      Volume: 17 Pages: 420-426

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state2011
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      J.Pept.Sci.

      Volume: 17 Pages: 420-426

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Enantioselective epoxidation of α,β-unsaturated ketones catalyzed by stapled helical L-Leu-based peptides2011
    • Author(s)
      Y. Demizu, N. Yamagata, S. Nagoya, Y. Sato, M. Doi, M. Tanaka, K. Nagasawa, H. Okuda, M. Kurihara
    • Journal Title

      Tetrahedron

      Volume: 67 Pages: 6155-6165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone2011
    • Author(s)
      Yamagata, N., Demizu, Y., Sato, Y., Doi, M., Tanaka, M., Nagasawa, K., Okuda, H., Kurihara, M
    • Journal Title

      Tetrahedron Letters

      Volume: 52 Pages: 798-801

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Conformational studies on peptides containing α,α-disubstituted α-amino acids : chiral cyclic α,α-disubstituted α-amino, acid as an α-helical inducer2011
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 3303-3312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Design of a stabilized short helical peptide and its application to catalytic enantioselective epoxidation of (E)-chalcone2011
    • Author(s)
      N.Yamagata, Y.Demizu, Y.Sato, M.Doi, M.Tanaka, K.Nagasawa, H.Okuda, M.Kurihara
    • Journal Title

      Tetrahedron Lett. 52

      Pages: 798-801

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Screw-Sense Control of Helical Oligopeptides Containing Equal Amounts of l- and d-Amino Acids2011
    • Author(s)
      Y. Demizu, M. Doi, M. Tanaka, H. Okuda, M. Kurihara
    • Journal Title

      Chem. Eur. J.,

      Volume: 17 Pages: 11107-11109

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Conformational studies on peptides containing α,α-disubstituted α-amino acids : chiral cyclic α,α-dsubstituted α-amino acid as an α-helical inducer2011
    • Author(s)
      Y.Demizu
    • Journal Title

      Org.Biomol.Chem.

      Volume: 9 Pages: 3303-3312

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Design, synthesis and X-ray crystallographic study of new nonsecosteroidal vitamin D receptor ligands2011
    • Author(s)
      Y.Demizu
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 21 Pages: 6104-6107

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor2011
    • Author(s)
      Y.Demizu
    • Journal Title

      Lett.Org.Chem.

      Volume: 8 Pages: 43-47

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Three-Dimensional Structural Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences in the Solid State2010
    • Author(s)
      Demizu, Y.
    • Journal Title

      J Org.Chem.

      Volume: 75 Pages: 5234-5239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Conformational analysis of water-soluble oligopeptide composed of chiral cyclic α, α-disubstituted α-amino acids2010
    • Author(s)
      Y.Demizu
    • Journal Title

      Peptide Science 2009

      Pages: 381-382

    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Controlling the helical screw sense of peptides by N-terminal proline2010
    • Author(s)
      N.Yamagata, Y.Demizu, Y.Sato, M.Oba, M.Tanaka, M.Doi, K.Nagasawa, H.Suemune, H.Okuda, M.Kurihara
    • Journal Title

      Peptide Science 2009

      Pages: 383-384

    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Three-dimensional structure control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state2010
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      J.Org.Chem.

      Volume: 75 Pages: 5234-5239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Conformational analysis of water-soluble oligopeptides composed of chiral cyclicα,α-disubstitutedα,-amino acids2010
    • Author(s)
      Y.Demizu, M.Tanaka, H.Suemune, M.Doi, Y.Sato, H.Okuda, M.Kurihara
    • Journal Title

      Peptide Science 2009

      Pages: 381-382

    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Conformations of peptides containing a chiral cyclic α,α-disubstituted α-amino acid within the sequence of Aib residues2010
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      J.Pept.Sci.

      Volume: 16 Pages: 621-626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      J.Pept.Sci. 16

      Pages: 153-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Three-dimensional structure control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state2010
    • Author(s)
      Y.Demizu, M.Doi, Y.Sato, M.Tanaka, H.Okuda, M.Kurihara
    • Journal Title

      J.Org.Chem. 75

      Pages: 5234-5239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Three-Dimensional Structural Control of Diastereomeric Leu-Leu-Aib-Leu-Leu-Aib Sequences in the Solid State2010
    • Author(s)
      Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M
    • Journal Title

      J. Org. Chem

      Volume: 75 Pages: 5234-5239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
    • Author(s)
      Demizu, Y., Yamagata, N., Sato, Y., Doi, M., Tanaka, M., Okuda, H., Kurihara, M
    • Journal Title

      J. Pept. Sci.

      Volume: 16 Pages: 153-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Computational study on helical structure of chiralα,α-disubstituted oligopeptides2010
    • Author(s)
      M.Kurihara, Y.Sato, N.Yamagata, Y.Demizu, H.Okuda, M.Nagano, M.Doi, M.Tanaka, H.Suemune
    • Journal Title

      Peptide Science 2009

      Pages: 385-386

    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Conformations of peptides containing a chiral cyclic-α,α-disubstituted α-amino acid within the sequence of Aib residues2010
    • Author(s)
      Y.Demizu, M.Tanaka, M.Doi, M.Kurihara, H.Okuda, H.Suemune
    • Journal Title

      J.Pept.Sci. 16

      Pages: 621-626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
    • Author(s)
      Demizu, Y.
    • Journal Title

      J.Pent. Sci.

      Volume: 16 Pages: 153-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues2010
    • Author(s)
      Demizu, Y.
    • Journal Title

      J.Pept.Sci.

      Volume: 16 Pages: 621-626

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Journal Article] Facile synthesis of optically active oxindoles by copper-catalyzed asymmetric monotosylation of prochiral 1,3-diols2010
    • Author(s)
      M.Kuriyama, S.Tanigawa, Y.Kubo, Y.Demizu, O.Onomura
    • Journal Title

      Tetrahedron : Asymmetry 21

      Pages: 1370-1373

    • NAID

      120002098362

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Controlling the helical screw sense of peptides with C-terminal L-valine2010
    • Author(s)
      Y.Demizu, N.Yamagata, Y.Sato, M.Doi, M.Tanaka, H.Okuda, M.Kurihara
    • Journal Title

      J.Pept.Sci. 16

      Pages: 153-158

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Solid-state conformation of diastereomeric -Pro-Pro-(Aib)_4 sequences2010
    • Author(s)
      M.Oba, Y.Demizu, N.Yamagata, Y.Sato, M.Doi, M.Tanaka, H.Suemune, H.Okuda, M.Kurihara
    • Journal Title

      Tetrahedron 66

      Pages: 2293-2296

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Helical-screw directions of diastereoisomeric cyclic α-amino acid oligomers2009
    • Author(s)
      M.Nagano, M.Tanaka, M.Doi, Y.Demizu, M.Kurihara, H.Suemune
    • Journal Title

      Org.Lett. 11

      Pages: 1135-1137

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Ring contraction of α,β-unsaturated cyclic amines with cis-dihydroxylation at the α,β-position,S.2009
    • Author(s)
      S.Libendi, Y.Demizu, Y.Matsumura, O.Onomura
    • Journal Title

      Heterocycles 77

      Pages: 311-321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Non-enzymatic kinetic resolut with chiral conner catalvstion of racemic α-hydroxyalkanephosphonates2009
    • Author(s)
      Y.Demizu, et al.
    • Journal Title

      Tetrahedron Lett. 37

      Pages: 5241-5244

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Direct electrochemical α-cyanation of N-protected cyclic amines, S. S. Libendi2009
    • Author(s)
      Y.Demizu, O.Onomura
    • Journal Title

      Org.Biomol.Chem. 7

      Pages: 351-356

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Computational study on helical structure of α,α-disubstituted oligopeptides containing chiral α-amino acids2009
    • Author(s)
      M.Kurihara, Y.Sato, N.Yamagata, H.Okuda, M.Nagano, Y.Demizu, M.Doi, M.Tanaka, H.Suemune
    • Journal Title

      Peptide Science 2008

      Pages: 149-150

    • NAID

      10027166112

    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Non-enzymatic kinetic resolution of racemic alpha-hydroxyalkanephosphonates with chiral copper catalyst2009
    • Author(s)
      Y.Demizu, A.Moriyama, O.Onomura
    • Journal Title

      Tetrahedron Lett.<Highlighted by Synfacts 1126 (2009)> 37

      Pages: 5241-5244

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008
    • Author(s)
      Y. Demizu, Y. Kubo, Y. Matsumura, O. Onomura
    • Journal Title

      Synlett

      Pages: 433-437

    • NAID

      120001096870

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls2008
    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Tetrahedron : Asymmetry 19

      Pages: 2659-2665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008
    • Author(s)
      Demizu, Y., et. al.
    • Journal Title

      Synlett 3

      Pages: 433-437

    • NAID

      120001096870

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Oxidative C-C bond cleavage of N-alkoxycarbonylated cyclic amines by sodium nitrite in trifluoroacetic acid2008
    • Author(s)
      O. Onomura, A. Moriyama, K. Fukae, Y. Yamamoto, T. Maki, Y. Matsumura, Y. Demizu
    • Journal Title

      Tetrahedron Lett 49

      Pages: 6728-6731

    • NAID

      120000912070

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Asymmetric electrochemical oxidation of 1,2-diols, aminoalcohols and aminoaldehydes in the presenceof chiral copper catalyst2008
    • Author(s)
      D. Minato, H. Arimoto, Y. Nagasue, Y. Demizu, O. Onomura
    • Journal Title

      Tetrahedron 64

      Pages: 6675-6683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Regioselective protection of sugars catalyzed by dimethyltin dichloride2008
    • Author(s)
      Y. Demizu, Y. Kubo, H. Miyoshi, T. Maki, Y. Matsumura, N. Moriyama, O. Onomura
    • Journal Title

      Org. Lett 10

      Pages: 5075-5077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Diastereoselective arylation of L-proline derivatives at the 5-position2008
    • Author(s)
      O. Onomura, P. G. Kirira, T. Tanaka, S. Tsukada, Y. Matsumura, Y. Demizu
    • Journal Title

      Tetrahedron 64

      Pages: 7498-7503

    • NAID

      120000911528

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Convenient synthesis of enantiomerically enriched bicyclic proline and the corresponding N-oxyls2008
    • Author(s)
      Y. Demizu, H. Shiigi, H. Mori, K. Matsumoto, O. Onomura
    • Journal Title

      Tetrahedron: Asymmetry 19

      Pages: 2659-2665

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Regioselective introduction of electrophiles into piperidine derivatives at the 4-position2008
    • Author(s)
      O. Onomura, N. Fujimura, T. Oda, Y. Matsumura, Y. Demizu
    • Journal Title

      Heterocycles 76

      Pages: 177-182

    • NAID

      120001348583

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Chiral azabicyclo-N-oxyls mediated enantioselective electrooxidation of sec-alcohols2008
    • Author(s)
      H. Shiigi, H.Mori, T. Tanaka, Y. Demizu, O. Onomura
    • Journal Title

      Tetrahedron Lett 49

      Pages: 5247-5251

    • NAID

      120000911612

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Non-enzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst2008
    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Synlett

      Pages: 433-437

    • NAID

      120001096870

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Effecient kinetic resolution of racemic-aminoaldehydes by oxidation with NIS2008
    • Author(s)
      D. Minato, Y. Nagasue, Y. Demizu, O. Onomura
    • Journal Title

      Angew. Chem. Int. Ed 47

      Pages: 9458-9461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Regioselective protection of sugars catalyzed by dimethyltin dichloride2008
    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Organic Letters 10

      Pages: 5075-5077

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Computational study on secondary structure of oligopeptides containing α,α-disubstituted α-amino acids2008
    • Author(s)
      M. Kurihara, Y. Sato, F. Kaneko, H. Okuda, M. Nagano, Y. Demizu, M. Doi, M. Tanaka, H. Suemune
    • Journal Title

      Peptide Science 2007

      Pages: 137-138

    • NAID

      10021906747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008
    • Author(s)
      Demizu, Y. et al.
    • Journal Title

      Tetrahedron Letters 49

      Pages: 48-52

    • NAID

      120000916320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008
    • Author(s)
      Demizu, Y., et. al.
    • Journal Title

      Tetrahedron Letters 49

      Pages: 48-52

    • NAID

      120000916320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] High regioselective in electrochemical α-methoxylation of N-protected cyclic amines2008
    • Author(s)
      S. S. Libendi, Y. Demizu, Y. Matsumura, O. Onomura
    • Journal Title

      Tetrahedron 64

      Pages: 3935-3942

    • NAID

      120003720803

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Efficient oxidation of alcohols electrochemically mediated by azabicyclo-N-oxyls2008
    • Author(s)
      Y. Demizu, H. Shiigi, T. Oda, Y. Matsumura, O. Onomura
    • Journal Title

      Tetrahedron Lett 49

      Pages: 48-52

    • NAID

      120000916320

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: Synthetic application to chiral seven-membered ring α,α-disubstituted α-amino acid2007
    • Author(s)
      M. Tanaka, Y. Demizu, M. Nagano, M. Hama, Y. Yoshida, M. Kurihara, H. Suemune
    • Journal Title

      J. Org. Chem 72

      Pages: 7750-7756

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Antiviral activity of 3-(3,5-dimethylbenzyl)uracil derivatives against HIV-1 and HCM2007
    • Author(s)
      T. Maruyama, Y. Demizu, S. Kozai, M. Witvrouw, C. Pannecouque, P. J. Balzarini, R. Snoecks, G. Andrei, E. De Clercq
    • Journal Title

      Nucleosides, Nucleotides & Nucleic Acids 26

      Pages: 1553-1558

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] 1,2-ジオール分子認識に基づく選択的分子変換反応2007
    • Author(s)
      松村功啓、尾野村治、出水庸介
    • Journal Title

      有機合成化学協会誌 第65巻

      Pages: 46-55

    • NAID

      10018578272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Controlling 310-helix and α-helix of short peptides in the solid state2007
    • Author(s)
      Y. Demizu, M. Tanaka, M. Nagano, M. Kurihara, M. Doi, T. Maruyama, H. Suemune
    • Journal Title

      Chem. Pharm. Bull 55

      Pages: 840-842

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Controlling 3_<10>-helix and α-helix of short peptides in the solid state2007
    • Author(s)
      Y.Demizu, M.Tanaka, M.Nagano, M.Kurihara, M.Doi, T.Maruyama, H.Suemune
    • Journal Title

      Chemical ＆ Pharmaceutical Bulletin. (in press)

    • NAID

      110006273081

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Asymmetric tosylation of racemic 2-hydroxyalkanamides with chiral copper catalyst2007
    • Author(s)
      O. Onomura, M. Mitsuda, T. T. M. Nguyen, Y. Demizu
    • Journal Title

      Tetrahedron Lett 48

      Pages: 9080-9084

    • NAID

      120000916321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Copper complex catalyzed asymmetric monosulfonylation of meso-vic-diols2007
    • Author(s)
      Y. Demizu, K. Matsumoto, O. Onomura, Y. Matsumura
    • Journal Title

      Tetrahedron Lett 48

      Pages: 7605-7609

    • NAID

      120000916324

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Computational study on conformation of oligopeptides containing chiral cyclic α,α-disubstituted a-amino acids2007
    • Author(s)
      M. Kurihara, Y. Sato, W. Hakamata, H. Okuda, Y. Demizu, M. Nagano, N. Kawabe, M. Doi, M. Tanaka, H. Suemune
    • Journal Title

      Peptides 2006

      Pages: 546-547

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Secondary structure of heteropeptides using chiral cyclic α,α-disubstituted amino acids2007
    • Author(s)
      M. Nagano, M. Tanaka, Y. Demizu, M. Kurihara, M. Doi, H. Suemune
    • Journal Title

      Peptides 2006

      Pages: 476-477

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Side-chain chiral centers of amino acids and helical-screw handedness of their peptides2007
    • Author(s)
      M. Tanaka, M. Nagano, Y. Demizu, K. Anan, M. Kurihara, M. Doi, H. Suemune
    • Journal Title

      Peptides 2006

      Pages: 268-269

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Asymmetric oxidation of 1,2-diols using N-bromosuccinimide in the presence of chiral copper catalyst2007
    • Author(s)
      O. Onomura, H. Arimoto, Y. Matsumura, Y. Demizu
    • Journal Title

      Tetrahedron Lett 48

      Pages: 8668-8672

    • NAID

      120000916322

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Journal Article] Kinetic resolution of vic-amino alcohols catalyzed by a chiral Cu(II) complex2006
    • Author(s)
      M.Mitsuda, T.Tanaka, T.Tanaka, Y.Demizu, O.Onomura, Y.Matsumura
    • Journal Title

      Tetrahedron Letters 47(46)

      Pages: 8073-8073

    • NAID

      120000916325

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Asymmetric desymmetrization of meso-vic-diols by carbamoylation catalyzed with chiral Cu(II) complex2006
    • Author(s)
      K.Matsumoto, M.Mitsuda, N.Ushijima, Y.Demizu, O.Onomura, Y.Matsumura
    • Journal Title

      Tetrahedron Letters 47(48)

      Pages: 8453-8453

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Synthesis of 6-arylthio analogs of 2'3'-dideoxy-3'-fluoroguanosine and their effect against hepatitis B virus replication2006
    • Author(s)
      T.Torii, T.Onishi, K.Izawa, T.Maruyama, Y.Demizu, J.Neyts, E.D.Clerq
    • Journal Title

      Nucleotides, Nucleotides ＆ Nucleic Acids 25(4-6)

      Pages: 655-655

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Electrochemical oxidation of L-prolinol derivative protected with 1-alkoxy-2,2,2-trifluoroethyl group2006
    • Author(s)
      O.Onomura, Y.Ishida, T.Maki, D.Minato, Y.Demizu, Y.Matsumura
    • Journal Title

      Electrochemistry 74(8)

      Pages: 645-645

    • NAID

      130002150955

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Side-Chain Chiral Centers of Amino Acid and Helical Screw Handedness of Its Peptides2005
    • Author(s)
      M.Tanaka, K.Anan, Y.Demizu, M.Kurihara, M.Doi, H.Suemune
    • Journal Title

      Journal of the American Chemical Society 127(33)

      Pages: 11570-11570

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Reaction of O6-Methylguanosine with Nitrite in the Presence of Carboxylic Acid : Synthesis of the Purin-2-yl Carboxylate2005
    • Author(s)
      T.Maruyama, N.Moriwaka, Y.Demizu, M.Ohtsuka
    • Journal Title

      Tetrahedron Letters 46(47)

      Pages: 8225-8225

    • Data Source
      KAKENHI-PROJECT-17790028

  • [Journal Article] Facile synthesis of stereoisomers of the non-secosteroidal ligand LG190178 and their evaluation using the mutant vitamin D receptor
    • Author(s)
      Y.Demizu, A.Nakatsu, S.Honzawa, A.Yamashita, T.Sugiura, A.Kittaka, S.Kato, H.Okuda, M.Kurihara
    • Journal Title

      Lett.Org.Chem. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Conformational studies on peptides containing α,α-disubstituted α-amno acids : chiral cyclic ,α,α-disubstituted α-amino acidas an α-helical inducer
    • Author(s)
      Y.Demizu, M.Doi, M.Kurihara, H.Okuda, M.Nagano, H.Suemune, M.Tanaka
    • Journal Title

      Org. Biomol.Chem. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Journal Article] Solid-phase nucleophilic fluorination
    • Author(s)
      Y.Demizu, K.Sano, N.Terayama, W.Hakamata, Y.Sato, H.Inoue, H.Okuda, M.Kurihara
    • Journal Title

      Synth. Commun. (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] 新規化合物及び医薬組成物2021
    • Inventor(s)
      2.出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
    • Industrial Property Rights Holder
      2.出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-016808
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Patent] 新規化合物及び医薬組成物2021
    • Inventor(s)
      出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
    • Industrial Property Rights Holder
      出水庸介，柴田識人，内藤幹彦，有竹浩介，横尾英知
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-016808
    • Filing Date
      2021
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Patent] 新規化合物及び抗コロナウイルス剤2020
    • Inventor(s)
      出水庸介ら
    • Industrial Property Rights Holder
      出水庸介ら
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-195723
    • Filing Date
      2020
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Patent] 構築物，及び，カーゴ分子を細胞内に輸送する方法2018
    • Inventor(s)
      出水庸介，三澤隆 史，大岡伸通，内藤幹彦
    • Industrial Property Rights Holder
      出水庸介，三澤隆 史，大岡伸通，内藤幹彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-000461
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Patent] 構築物，及び，カーゴ分子を細胞内に輸送する方法2018
    • Inventor(s)
      出水庸介，三澤隆史，大岡伸通，内藤幹彦
    • Industrial Property Rights Holder
      出水庸介，三澤隆史，大岡伸通，内藤幹彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2018-000461
    • Filing Date
      2018
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Patent] 細胞膜透過性を有するペプチド，構築物，及び，カーゴ分子を細胞内に輸送する方法2017
    • Inventor(s)
      出水庸介，栗原正明，三澤隆史
    • Industrial Property Rights Holder
      出水庸介，栗原正明，三澤隆史
    • Industrial Property Rights Type
      特許
    • Filing Date
      2017-02-02
    • Overseas
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Patent] 細胞膜透過性を有するペプチド，構築物，及び，カーゴ分子を細胞内に輸送する方法2016
    • Inventor(s)
      出水庸介，栗原正明，三澤隆史
    • Industrial Property Rights Holder
      出水庸介，栗原正明，三澤隆史
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2016-018416
    • Filing Date
      2016-02-02
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Patent] ラムノシドエステル誘導体およびその製造方法2010
    • Inventor(s)
      尾野村治、出水庸介、久保裕紀、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、久保裕紀、岩崎史哲
    • Patent Publication Number
      2010-030916
    • Acquisition Date
      2010-02-12
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] ピラノシドエステル化合物およびその製造方法2009
    • Inventor(s)
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、岩崎史哲
    • Patent Publication Number
      2009-215175
    • Acquisition Date
      2009-09-24
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] 光学活性α-スルポニルオキシカルボン酸アミド誘導体及びそれらの製造方法2009
    • Inventor(s)
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、岩崎史哲
    • Patent Publication Number
      2009-091327
    • Acquisition Date
      2009-04-30
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] グルコシドエステル誘導体およびその製造方法2009
    • Inventor(s)
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、岩崎史哲
    • Patent Publication Number
      2009-221161
    • Acquisition Date
      2009-10-01
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] キシロシドエステル誘導体およびその製造方法2009
    • Inventor(s)
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、岩崎史哲
    • Patent Publication Number
      2009-227610
    • Acquisition Date
      2009-10-08
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] 光学活性アミノ酸エステル誘導体,および光学活性アミノアセタール誘導体の製造方法2009
    • Inventor(s)
      尾野村治、出水庸介、山本博将
    • Industrial Property Rights Holder
      尾野村治、出水庸介、山本博将
    • Patent Publication Number
      2009-227594
    • Acquisition Date
      2009-10-08
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Patent] 光学活性モノスルホネート化合物の製造方法2008
    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Patent Publication Number
      2008-290981
    • Acquisition Date
      2008-12-04
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性α-アシルオキシリン酸誘導体の製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Number
      2008-286370
    • Filing Date
      2008-11-07
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 脂肪族ジカルボン酸化合物の製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-025594
    • Filing Date
      2008-02-05
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] ピラノシドジエステル化合物及びその製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-057503
    • Filing Date
      2008-03-07
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] キシロシドエステル誘導体およびその製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-075320
    • Filing Date
      2008-03-24
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] グルコシドエステル誘導体およびその製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-068124
    • Filing Date
      2008-03-17
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] ピラノシドジエステル化合物及びその製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-057503
    • Filing Date
      2008-03-07
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] グルコシドエステル誘導体およびその製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-068124
    • Filing Date
      2008-03-17
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性アミノ酸エステル誘導体、及び光学活性アミノアセタール誘導体の製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 山本博将
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 山本博将
    • Industrial Property Number
      2008-072911
    • Filing Date
      2008-03-21
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性アミノ酸エステル誘導体、及び光学活性アミノアセタール誘導体の製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 山本博将
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 山本博将
    • Industrial Property Number
      2008-072911
    • Filing Date
      2008-03-21
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] α、α-ジ置換環状含窒素化合物の製造方法2008
    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Patent Publication Number
      2008-240106
    • Acquisition Date
      2008-10-09
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性ビスオキサゾリン-銅錯体を不斉触媒とするN-保護アミノアルコール化合物の不斉エステル化反応2008
    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Patent Publication Number
      2008-037865
    • Acquisition Date
      2008-02-21
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 含窒素レドックス触媒2008
    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Filing Date
      2008-03-28
    • Overseas
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 含窒素レドックス触媒2008
    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Filing Date
      2008-03-28
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 脂肪族ジカルボン酸化合物の製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-025594
    • Filing Date
      2008-02-05
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性ビスオキサゾリン-銅錯体を不斉触媒おするN-保護アミノアルコール化合物の不斉エステル化反応2008
    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Patent Publication Number
      2008-037865
    • Acquisition Date
      2008-02-21
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性α-アシルオキシリン酸誘導体の製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 森山敦, 岩崎史哲
    • Industrial Property Number
      2008-286370
    • Filing Date
      2008-11-07
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] ラムノシドエステル誘導体およびその製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Number
      2008-192243
    • Filing Date
      2008-07-25
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性モノスルホネート化合物の製造方法2008
    • Inventor(s)
      松村功啓, 尾野村冶, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村冶, 出水庸介
    • Patent Publication Number
      2008-290981
    • Acquisition Date
      2008-12-04
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] ラムノシドエステル誘導体およびその製造方法2008
    • Inventor(s)
      尾野村冶, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 久保裕紀, 岩崎史哲
    • Industrial Property Number
      2008-192243
    • Filing Date
      2008-07-25
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] α, α-ジ置換環状含窒素化合物の製造方法2008
    • Inventor(s)
      松村功啓, 尾野村治, 出水庸介
    • Industrial Property Rights Holder
      松村功啓, 尾野村治, 出水庸介
    • Patent Publication Number
      2008-240106
    • Acquisition Date
      2008-10-09
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] キシロシドエステル誘導体およびその製造方法2008
    • Inventor(s)
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村治, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2008-075320
    • Filing Date
      2008-03-24
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性α-スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法2007
    • Inventor(s)
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Rights Holder
      尾野村治、出水庸介、岩崎史哲
    • Industrial Property Number
      2007-265700
    • Filing Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Patent] 光学活性α-スルホニルオキシカルボン酸アミド誘導体及びそれらの製造方法2007
    • Inventor(s)
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Rights Holder
      尾野村冶, 出水庸介, 岩崎史哲
    • Industrial Property Number
      2007-265700
    • Filing Date
      2007-10-11
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] シリビニンの高機能化を目指した創薬研究2021
    • Author(s)
      水野美麗，森一憲，土屋圭輔，髙木孝士，三澤隆史，出水庸介，柴沼質子，福原潔
    • Organizer
      日本農芸化学会2021年度大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ヘリカル構造制御に基づく高機能生理活性ペプチドの創出2021
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第141回年会シンポジウム：中分子創薬研究のフロンティア ～生体分子を標的とした機能性ペプチドの創製～
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] LSD類縁体MiPLAの合成とその性状解析2021
    • Author(s)
      正田卓司，河村麻衣子，花尻瑠璃，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] カチオン性グアニンアナログを導入したペプチド核酸オリゴマーによるストランドインベージョンの検討2021
    • Author(s)
      森谷俊介、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
    • Organizer
      日本薬学会第１４１年会
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] アミン骨格を有するc-di-GMP誘導体の合成とバイオフィルム形成阻害評価2021
    • Author(s)
      辻厳一郎，池田健太郎，栁瀬雄太，林克彦，工藤由起子，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 抗アデノウイルス活性を期待した2’-デオキシ炭素環ヌクレオシドの合成2021
    • Author(s)
      荒井慎之介，斎藤智亜季，水石彩菜，三澤隆史，出水庸介，栗原正明，紺野奇重
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 免疫系制御を指向した新規STINGリガンドの効率的探索2021
    • Author(s)
      栁瀨雄太，池田健太郎，辻厳一郎，柴田識人，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 光異性化に基づくエストロゲン受容体の活性制御2021
    • Author(s)
      土屋圭輔，梅野智大，辻厳一郎，横尾英知，福原潔，三澤隆史，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 造血器型プロスタグランジン合成酵素を標的とした分解誘導剤の開発2021
    • Author(s)
      横尾英知，柴田識人，永沼美弥子，村上優希，藤井清永，伊藤貴仁，有竹浩介，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 核内受容体を標的とするペプチド型分解誘導剤の開発2021
    • Author(s)
      伊藤貴仁，横尾英知，大岡伸通，内藤幹彦，井上貴雄，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 5,6,7,8-Tetrahydronaphtalene骨格を用いた選択的TGR5アゴニストの開発2021
    • Author(s)
      三澤隆史，照井龍晟，栁瀨雄太，横尾英知，槇島誠，須原義智，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ペプチドリガンドを利用したタンパク質分解誘導キメラ分子の開発2021
    • Author(s)
      大岡伸通，横尾英知，井上貴雄，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] アプタマーをリガンドとしたエストロゲン受容体分解誘導剤の創製2021
    • Author(s)
      辻村はるな，永沼美弥子，大岡伸通，須原義智，松野研司，内藤幹彦，井上貴雄，辻厳一郎，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 両親媒性抗菌ペプチドフォルダマーの合理的設計2021
    • Author(s)
      平野元春，齋藤千尋，後藤千尋，川野竜司，三澤隆史，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] デコイ核酸をリガンドとしたエストロゲン受容体分解誘導剤の創製2021
    • Author(s)
      永沼美弥子，辻村はるな，大岡伸通，松野研司，須原義智，内藤幹彦，上貴雄，辻厳一郎，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] LXRを標的とした分解誘導剤の開発2021
    • Author(s)
      許涵喬，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 非天然型アミノ酸含有ヘリカルペプチドによるVDR-コアクチベータ相互作用阻害剤の創製2021
    • Author(s)
      田京茉実，佐藤友海，石田寛明，山本恵子，三澤隆史，出水庸介
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ヘリカル構造制御に基づく高機能生理活性ペプチドの創出2021
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第141回年会シンポジウム：中分子創薬研究のフロンティア 生体分子を標的とした機能性ペプチドの創製
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] カチオン性グアニンアナログを導入したペプチド核酸オリゴマーによるストランドインベージョンの検討2021
    • Author(s)
      森谷俊介，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
    • Organizer
      日本薬学会第141回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of post-functionalizable antimicrobial peptide foldamers2020
    • Author(s)
      三澤隆史，平野元春，横尾英知，出水庸介
    • Organizer
      第57回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of stapled peptides against inhibiting VDR-coactivator interaction2020
    • Author(s)
      佐藤友海，田京茉実，三澤隆史，石田寛明，山本恵子，出水庸介
    • Organizer
      第57回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Carbocyclic-2'-deoxynucleosideの合成研究 －carbocyclic-2'-deoxyuridineの合成－2020
    • Author(s)
      斎藤智亜季，水石彩菜，目黒公太郎，植松明星，原島利彰，林宏典，児玉栄一，三澤隆史，出水庸介，栗原正明，紺野奇重
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 長鎖アルキル基を有するエストロゲン受容体分解誘導剤のERサブタイプ選択性に関する検討2020
    • Author(s)
      津田萌菜，正田卓司，井上英史，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2020
    • Author(s)
      出水庸介
    • Organizer
      第58回日本生物物理学会年会シンポジウム：膜の海を旅するペプチド 脂質膜とペプチドの相互作用研究の新展開
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] c-di-GMP誘導体の合成とバイオフィルム形成阻害評価2020
    • Author(s)
      池田健太郎，栁瀨雄太，辻厳一郎，林克彦，工藤（原）由起子，出水庸介
    • Organizer
      第34回日本バイオフィルム学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 造血器型プロスタグランジン合成酵素を標的とした分解誘導剤の開発2020
    • Author(s)
      横尾英知，柴田識人，永沼美弥子，伊藤貴仁，内藤幹彦，有竹浩介，出水庸介
    • Organizer
      第64回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 核内受容体分解誘導ペプチドの創製2020
    • Author(s)
      横尾英知，大岡伸通，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 新規TGR5リガンドの開発2020
    • Author(s)
      照井龍晟，三澤隆史，須原義智，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 国内標品確保のためのフェンタニル構造類似化合物の合成研究2020
    • Author(s)
      辻厳一郎，三澤隆史， 正田卓司，河村麻衣子，花尻（木倉）瑠璃，袴塚高志，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ペプチド核酸によるdouble duplex invasionを応用した目視可能判定可能な一塩基多型検出系の検討2020
    • Author(s)
      森谷俊介，笹祐子，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する研究2020
    • Author(s)
      馬庭愛加，辻厳一郎，内山奈穂子，細江潤子，大槻崇，松藤寛，合田幸広，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] プエラリア・ミリフィカ由来kwakhurinの形式全合成と相対モル感度係数を利用したプエラリア・ミリフィカ含有食品中のmiroestrolの定量2020
    • Author(s)
      政田さやか，遊佐仁曉，辻厳一郎，横尾英知，細江潤子，新井玲子，田中誠司，出水庸介，袴塚高志，合田幸広，内山奈穂子
    • Organizer
      第62回天然有機化合物討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 新しい細胞膜透過性ペプチドフォルダマーの開発と細胞特異的なsiRNAの導入2020
    • Author(s)
      大岡伸通，三澤隆史，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 新規TGR5リガンドの開発2020
    • Author(s)
      三澤隆史，照井龍晟，槇島眞，須原義智，出水庸介
    • Organizer
      日本ビタミン学会第72回大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] LXRを標的とした分解誘導剤の開発2020
    • Author(s)
      根本可南子，辻厳一郎，大岡伸通，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 非天然型構造を有するペプチド医薬品の非臨床評価の方向性2020
    • Author(s)
      斎藤嘉朗，出水庸介
    • Organizer
      第47回日本毒性学会学術年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 非天然型アミノ酸を有するヘリカルペプチドを利用したタンパク質分解誘導キメラ分子の開発2020
    • Author(s)
      大岡伸通，横尾英知，内藤幹彦，井上貴雄，出水庸介
    • Organizer
      第43回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] NMRフィンガープリント法を用いたペプチド医薬品の立体構造解析2020
    • Author(s)
      三澤隆史，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 核内受容体分解誘導ペプチドの創製2020
    • Author(s)
      横尾英知，大岡伸通，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 国際調和に向けた日本薬局方の医薬品各条における試験法の改定に関する検討：qNMRを利用した類縁物質の純度決定2020
    • Author(s)
      辻厳一郎，伊藤貴仁，内山奈穂子，細江潤子，合田幸広，出水庸介
    • Organizer
      第2回日本定量ＮＭＲ研究会年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Temperature-dependent formation of N-nitrosodimethylamine (NDMA) during the storage of ranitidine reagent powders and tablets2020
    • Author(s)
      Abe Y., Yamamoto, E., Yoshida, Masada, S., Yokoo, H., Tsuji, G., Uchiyama, N., Hakamatsuka, T., Demizu, Y., Izutsu, K., Goda, Y., Okuda, H.
    • Organizer
      AAPS 2020 PHARMSCI 360
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Carbocyclic-2'-deoxynucleosideの合成研究 －carbocyclic-2'-deoxy-7-deazaadenosineの合成－2020
    • Author(s)
      水石彩菜，斎藤智亜季，目黒公太郎，植松明星，原島利彰，林宏典，児玉栄一，三澤隆史，出水庸介，栗原正明，紺野奇重
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2020
    • Author(s)
      出水庸介
    • Organizer
      第10回レギュラトリーサイエンス学会学術大会
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 抗アデノウイルス活性を期待した炭素環2’-デオキシ炭素環7-デアザアデノシンの合成2020
    • Author(s)
      今田敦之，水石彩菜，紺野奇重，三澤隆史，出水庸介，栗原正明，藤井幹雄
    • Organizer
      第64回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ペプチド核酸によるdouble duplex invasionを応用した目視判定可能な一塩基多型検出系の検討2020
    • Author(s)
      森谷俊介、笹祐子、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
    • Organizer
      日本薬学会第１４０年会
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] STINGを標的としたCDN誘導体の設計と合成2020
    • Author(s)
      栁瀨雄太，池田健太郎，辻厳一郎，柴田識人，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2020
    • Author(s)
      平野元春，後藤千尋，三澤隆史，出水庸介
    • Organizer
      第57回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ステープル構造を持つ抗菌ペプチドフォルダマーの開発2020
    • Author(s)
      平野元春，後藤千尋，林克彦，菊池裕，三澤隆史，工藤由起子，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2020
    • Author(s)
      出水庸介
    • Organizer
      第10回レギュラトリーサイエンス学会学術大会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 発がん因子BCR-ABLの脱ユビキチン化は慢性骨髄性白血病細胞の増殖に必要である2020
    • Author(s)
      柴田識人，大岡伸通，辻厳一郎，出水庸介，内藤幹彦
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 疎水性タグを利用したCRABP分解誘導剤の開発2020
    • Author(s)
      正田卓司，大岡伸通，辻厳一郎，井上英史，内藤幹彦，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ステープル構造を持つ抗菌ペプチドフォルダマーの開発2020
    • Author(s)
      平野元春，後藤千尋，林克彦，菊池裕，三澤隆史，工藤由起子，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] アミン骨格を利用した環状ジヌクレオチド誘導体の合成とバイオフィルム形成阻害評価2020
    • Author(s)
      池田健太郎，栁瀨雄太，辻厳一郎，林克彦，菊池裕，工藤（原）由起子，出水庸介
    • Organizer
      日本薬学会第140回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 抗アデノウイルス活性を期待した炭素環2’-デオキシ炭素環ピリミジンヌクレオシドの合成2020
    • Author(s)
      石綱遥，斎藤智亜季，紺野奇重，三澤隆史，出水庸介，栗原正明，藤井幹雄
    • Organizer
      第64回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of peptide-based degraders against estrogen and androgen receptor2020
    • Author(s)
      横尾英知，大岡伸通，内藤幹彦，井上貴雄，出水庸介
    • Organizer
      第57回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 中分子ペプチド医薬品の非臨床安全性評価における留意点2020
    • Author(s)
      斎藤嘉朗，出水庸介
    • Organizer
      第10回レギュラトリーサイエンス学会学術大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] アミン構造を基盤とした環状ジヌクレオチド等価体の創製2019
    • Author(s)
      栁瀨雄太，池田健太郎，辻厳一郎，林克彦，菊池裕，工藤由起子，出水庸介
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Peptide foldamers in drug discovery2019
    • Author(s)
      Demizu Y, Goto C, Misawa T, Tsuji G.
    • Organizer
      26th American Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] マガイニン2配列を基にした安定化ヘリカルペプチドの開発2019
    • Author(s)
      後藤千尋，平野元春，林克彦，菊池裕，工藤由起子，三澤隆史，出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 新しいユビキチンリガーゼを利用して標的タンパク質を分解するキメラ化合物の開発2019
    • Author(s)
      大岡伸通、辻厳一郎、正田卓司、藤里卓磨、栗原正明、出水庸介、内藤幹彦
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2019
    • Author(s)
      森谷俊介，笹祐子，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
    • Author(s)
      Misawa T, Ohoka N, Goto C, Oba M, Tanaka M, Naito M, Demizu Y.
    • Organizer
      European Symposium on Organic Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 7-Aminomethyl-7-deazaguanineをもつPNAオリゴマー2019
    • Author(s)
      森谷俊介，柴崎初音，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
    • Organizer
      第45回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] siRNAを高効率で細胞内に導入する細胞膜透過性ペプチドフォルダマーの開発2019
    • Author(s)
      大岡伸通，三澤隆史，内藤幹彦，出水庸介
    • Organizer
      第42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] ヘリカルテンプレートペプチドの合成とpost-modificationによる機能化2019
    • Author(s)
      三澤隆史，出水庸介
    • Organizer
      日本薬学会第139回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 芳香族複素環を有するエストロゲン受容体アンタゴニストの構造活性相関研究2019
    • Author(s)
      永沼美弥子，横尾英知，三澤隆史，松野研司，辻厳一郎，出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
    • Author(s)
      出水庸介
    • Organizer
      有機合成化学協会九州山口支部講演会「合成有機化学のフロンティア」
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      ケミカルバイオロジー第14回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
    • Author(s)
      出水庸介
    • Organizer
      有機合成化学協会九州山口支部講演会「合成有機化学のフロンティア」
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ヘリカル構造に着目した抗菌ペプチドの開発とその毒性評価に関する研究2019
    • Author(s)
      後藤千尋，三澤隆史，菊池裕，出水庸介
    • Organizer
      日本薬学会第139回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019
    • Author(s)
      出水庸介
    • Organizer
      MOEフォーラム2019
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 新規カチオン性グアニンアナログをもつPNAオリゴマー2019
    • Author(s)
      森谷俊介、柴崎初音、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
    • Organizer
      日本薬学会第１３９年会
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] 強い抗菌活性を示す両親媒性ペプチドフォルダマーの開発2019
    • Author(s)
      後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ペプチドフォルダマー創薬研究2019
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第139回年会シンポジウム:フォルダマーの魅力-新たな創薬への可能性-
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] ペプチドフォルダマー創薬研究2019
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第139回年会シンポジウム：フォルダマーの魅力-新たな創薬への可能性-
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2019
    • Author(s)
      出水庸介
    • Organizer
      第4回レギュラトリーサイエンス公開シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 7-Aminomethyl-7-deazaguanineをもつPNAの合成2019
    • Author(s)
      森谷俊介、柴崎初音、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史、杉山　亨
    • Organizer
      第４５回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] イオンモビリティー質量分析計を用いた生体試料中フェンタニル類スクリーニング分析法の検討2019
    • Author(s)
      河村麻衣子，辻厳一郎，三澤隆史，出水庸介，袴塚高志，花尻瑠理
    • Organizer
      日本法中毒学会第38年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 非天然型アミノ酸の開発と含有ペプチドの二次構造制御2019
    • Author(s)
      出水庸介
    • Organizer
      CMC+AndTech FORUM特殊ペプチドの合成技術と創薬の最新動向
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019
    • Author(s)
      出水庸介
    • Organizer
      MOEフォーラム2019
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497

  • [Presentation] 強い抗菌活性を示す両親媒性ペプチドフォルダマーの開発2019
    • Author(s)
      後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] フェンタニル類似化合物の化学合成に関する研究2019
    • Author(s)
      辻厳一郎，三澤隆史，河村麻衣子，花尻瑠理，袴塚高志，出水庸介
    • Organizer
      第56回全国衛生科学技術協議会年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発とDDSキャリアへの応用2019
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第13回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] An approach toward visual detection of single nucleotide polymorphism using pseudocomplementary peptide nucleic acid2019
    • Author(s)
      Shun-suke Moriya, Yuko Sasa, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, Atsushi Kittaka, and Toru Sugiyama
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] HPLCによる高血圧治療薬バルサルタン中N-nitrosodimethylamine (NDMA)の迅速定量法2019
    • Author(s)
      内山奈穂子，政田さやか，辻厳一郎，新井玲子，出水庸介，袴塚高志，堤智昭，穐山浩，阿部康弘，伊豆津健一，合田幸広，奥田晴宏
    • Organizer
      第86回日本分析化学会有機微量分析研究懇談会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 医薬品に混入する懸念のあるN-nitrosodimethylamine(NDMA)の迅速分析法の開発2019
    • Author(s)
      政田さやか, 辻厳一郎, 新井玲子, 内山奈穂子, 出水庸介, 袴塚高志, 堤智明, 穐山浩, 阿部康弘, 原矢佑樹, 伊豆津健一, 合田幸広, 奥田晴宏
    • Organizer
      第56回全国衛生科学技術協議会年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of small molecule chimeras that recruit aryl-hydrocarbon receptor (AhR) E3 ligase to induce degradation of target proteins2019
    • Author(s)
      Ohoka, N., Tsuji, G., Shoda, T., Fujisato, T., Kurihara, M., Demizu, Y., Naito, M.
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Peptide foldamers in drug discovery2019
    • Author(s)
      Demizu, Y., Goto, C., Misawa, T., Tsuji, G.
    • Organizer
      26th American Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 中分子ペプチド医薬品の開発効率化に資するレギュラトリーサイエンス研究2019
    • Author(s)
      出水庸介
    • Organizer
      2019年度衛研シンポジウム
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497

  • [Presentation] Peptide foldamers in drug discovery2019
    • Author(s)
      Tsuji, G., Misawa, T., Demizu, Y.
    • Organizer
      27th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 分析用標品確保のためのフェンタニル構造類似化合物の合成に関する研究2019
    • Author(s)
      辻厳一郎，三澤隆史，河村麻衣子，花尻瑠理，袴塚高志，出水庸介
    • Organizer
      日本法中毒学会第38年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] M7(R2):「潜在的発がんリスクを低減するための医薬品中DNA反応性(変異原性)不純物の評価及び管理」に対する補遺2019
    • Author(s)
      出水庸介
    • Organizer
      第40回ICH即時報告会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2019
    • Author(s)
      後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] Development of antimicrobial peptide foldamers based on Magainin 2 sequence2019
    • Author(s)
      後藤千尋，平野元春，林克彦，三澤隆史，菊池裕，出水庸介
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
    • Author(s)
      出水庸介
    • Organizer
      第1回新学術「ケモユビキチン」班会議・第2回ユビキチン研究会合同会議
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Design and synthesis of 4-(2-pyrrolyl)-4-phenylheptane derivatives as estrogen receptor ligands2019
    • Author(s)
      Tsuji, G., Naganuma, M., Yokoo, H., Misawa, T., Matsuno, K., Demizu, Y.
    • Organizer
      17th Annual Discovery on TARGET
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 新しいユビキチンリガーゼをリクルートして標的蛋白質を分解するキメラ化合物の開発と抗がん剤としての可能性2019
    • Author(s)
      大岡伸通，辻厳一郎，正田卓司，藤里卓磨，出水庸介，内藤幹彦
    • Organizer
      第23回日本がん分子標的治療学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2019
    • Author(s)
      平野元春，後藤千尋，林克彦，三澤隆史，菊池裕，工藤由起子，出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 新規環状ジヌクレオチド誘導体の合成とバイオフィルム形成阻害能の評価2019
    • Author(s)
      池田健太郎，栁瀨雄太，辻厳一郎，林克彦，菊池裕，工藤由起子，出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of peptide foldamers changing their secondary structures in response to the environmental milieu2019
    • Author(s)
      Oba, M., Furukawa, K., Nonaka, H., Demizu, Y., Tanaka, M.
    • Organizer
      26th American Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤としたペプチド創薬研究2019
    • Author(s)
      出水庸介
    • Organizer
      有機合成化学協会九州山口支部講演会
    • Invited
    • Data Source
      KAKENHI-ORGANIZER-18H05497

  • [Presentation] ヘリカル構造制御に基づく抗菌ペプチドフォルダマーの開発2019
    • Author(s)
      平野元春，後藤千尋，林克彦，三澤隆史，菊池裕，工藤由起子，出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of amphipathic cell-penetrating foldamers for delivery of biomacromolecules2019
    • Author(s)
      Misawa, T., Ohoka, N., Goto, C., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
    • Organizer
      European Symposium on Organic Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 中分子ペプチド医薬品開発に向けた規制上の課題と取組2019
    • Author(s)
      出水庸介
    • Organizer
      中分子ペプチド医薬品開発に向けた規制上の課題と取組
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] Development of cell-penetrating foldamers for delivery of biomacromolecules2019
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第56回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 創薬研究および違法薬物の規制におけるインシリコ技術の活用2019
    • Author(s)
      出水庸介
    • Organizer
      MOEフォーラム2019
    • Invited
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 新規カチオン性グアニンアナログをもつPNAオリゴマー2019
    • Author(s)
      森谷俊介，柴崎初音，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史，杉山亨
    • Organizer
      日本薬学会第139回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Peptide foldamers in drug discovery2019
    • Author(s)
      Tsuji G, Misawa T, Demizu Y.
    • Organizer
      27th French-Japanese Symposium on Medicinal and Fine Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] アミロイドβを創薬標的としたシリビニン誘導体の開発2019
    • Author(s)
      水野美麗，森一憲，三澤隆史，高木孝士，出水庸介，柴沼質子，福原潔
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第35回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] マガイニン2配列を基にした安定化ヘリカルペプチドの開発2019
    • Author(s)
      後藤千尋，平野元春，林克彦，菊池裕，工藤由起子，三澤隆史，出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 生体高分子を効率的に細胞内へ輸送する細胞膜高透過性フォルダマーの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      ケミカルバイオロジー第14回年会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] Synthesis of alpha-exo-methylene ketones from alpha,alpha-disubstituted allyl alcohols by electrochemical oxidative migration2019
    • Author(s)
      Yamamoto, K., Kikuchi, N., Hamamizu, T., Yoshimatsu, H., Kuriyama, M., Demizu, Y., Onomura, O.
    • Organizer
      The 4th International Symposium on Process Chemistry
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 生体高分子を細胞内に導入するキャリアペプチドの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] アミン骨格を基盤とした環状ジヌクレオチド等価体の合成とバイオフィルム形成阻害能の評価2019
    • Author(s)
      池田健太郎，栁瀨雄太，辻厳一郎，林克彦，菊池裕，出水庸介
    • Organizer
      第63回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 生体分子を細胞内に輸送する細胞膜透過性ペプチドフォルダマーの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 芳香族/複素環骨格を有するエストロゲン受容体調整薬の創製2019
    • Author(s)
      永沼美弥子，三澤隆史，辻厳一郎，横尾英知，松野研司，出水庸介
    • Organizer
      第37回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] バイオフィルム測定によるMycoplasma pneumoniaeに対する抗菌成分のスクリーニング系の構築2019
    • Author(s)
      林克彦，三澤隆史，後藤千尋，出水庸介，工藤由起子，菊池裕
    • Organizer
      第46回日本マイコプラズマ学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 生体高分子を細胞内に効率的に輸送するキャリアペプチドの開発2019
    • Author(s)
      三澤隆史，大岡伸通，後藤千尋，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第35回日本DDS学会学術集会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析2018
    • Author(s)
      河村麻衣子，三澤隆史，出水庸介，花尻瑠理，袴塚高志
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基軸とした細胞膜高透過性ペプチドの開発2018
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第50回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Peptide foldamers in drug discovery2018
    • Author(s)
      Demizu, Y., Misawa, T., Tsuji, G.
    • Organizer
      Bordeaux 2018 Symposium on Foldamers
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] タンパク質の寿命を制御できる分子の開発2018
    • Author(s)
      出水庸介
    • Organizer
      生体分子コバレント修飾の革新的解析拠点形成シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] タンパク質の寿命を制御できる分子の開発2018
    • Author(s)
      出水庸介
    • Organizer
      生体分子コバレント修飾の革新的解析拠点形成シンポジウム(招待講演)
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析2018
    • Author(s)
      古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖上にのみ不斉中心を持つ環状ジ置換アミノ酸よりなるヘリカルペプチドの巻き方制御2018
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，田中正一
    • Organizer
      第16回次世代を担う有機化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発と核酸デリバリーへの応用2018
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第34回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] PNA oligomers possessing PreQ1 as a cationic analogue of guanine2018
    • Author(s)
      Sugiyama, T., Shibasaki, H., Moriya, S., Kuwata, K., Imamura, Y., Demizu, Y., Kurihara, M., Kittaka, T.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Post-modificationによる官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018
    • Author(s)
      出水庸介，三澤隆史，辻厳一郎
    • Organizer
      第48回複素環化学討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 核酸デリバリーを指向した細胞膜高透過性ペプチドフォルダマーの開発2018
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第12回バイオ関連化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 液体クロマトグラフィー／多段階質量分析を利用した特殊環状ペプチドの構造解析2018
    • Author(s)
      橋井則貴，三澤隆史，鈴木琢雄，出水庸介，石井明子
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖上にキラルなアセタールを有する環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，田中正一
    • Organizer
      第48回複素環化学討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018
    • Author(s)
      出水庸介，三澤隆史，大岡伸通，服部隆行，内藤幹彦
    • Organizer
      第44回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価2018
    • Author(s)
      辻厳一郎，小林寛幸，三澤隆史，木下恵愛，松野研司，出水庸介
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 種々の側鎖官能基を有する環状α,α-ジ置換アミノ酸の合成と含有ペプチドの機能評価2018
    • Author(s)
      辻厳一郎，小林寛幸，三澤隆史，木下恵愛，松野研司，出水庸介
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 正電荷を帯びたグアニン誘導体をもつPNAオリゴマーの合成2018
    • Author(s)
      杉山　亨、柴崎初音、森谷俊介、桑田啓子、今村保忠、出水庸介、栗原正明、橘高敦史
    • Organizer
      第３６回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] 正電荷を帯びたグアニン誘導体を持つPNAオリゴマーの合成2018
    • Author(s)
      杉山亨，柴崎初音，森谷俊介，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of helix-stabilized amphipathic cell-penetrating peptides for siRNA delivery2018
    • Author(s)
      Misawa, T., Ohoka, N., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
    • Organizer
      35th European Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Low pH-responsive cyclic alpha,alpha-disubstituted alpha-amino acids for controlling secondary structures of peptide foldamers2018
    • Author(s)
      Oba, M., Furukawa, K., Toyama, K., Opiyo, G. O., Demizu, Y., Kurihara, M., Doi, M., Tanaka, M.
    • Organizer
      Bordeaux 2018 Symposium on Foldamers
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Post-modificationによる官能基修飾可能なα,α-ジ置換アミノ酸の設計と合成2018
    • Author(s)
      辻厳一郎，三澤隆史，出水庸介
    • Organizer
      ケミカルバイオロジー第13回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Post-modification による官能基修飾 可能なα,α-ジ置換アミノ酸の設計と合成2018
    • Author(s)
      出水庸介，三澤隆史，辻厳一郎
    • Organizer
      第 48 回複素環化学討論会
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] 側鎖にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドのヘリックス二次構造2018
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，田中正一
    • Organizer
      第28回福岡万有シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018
    • Author(s)
      杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Helical secondary structures of peptides composed of cyclic amino acids with a chiral acetal moiety2018
    • Author(s)
      Eto, R., Oba, M., Ueda, A., Doi, M., Demizu, Y., Kurihara, M., Tanaka, M.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第36回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 核酸医薬を細胞内に導入するオリゴペプチドの開発2018
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      ケミカルバイオロジー第13回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖上にキラルなアセタールを有する4員環状ジ置換アミノ酸よりなるペプチドの二次構造解析2018
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018
    • Author(s)
      三澤隆史，諫田泰成，出水庸介
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Peptide foldamers in drug discovery2018
    • Author(s)
      Demizu, Y., Misawa, T., Tsuji, G.
    • Organizer
      Bordeaux 2018 Symposium on Foldamers
    • Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] LC-CDを用いた危険ドラッグMethylphenidate類似体のキラル分析2018
    • Author(s)
      河村麻衣子，三澤隆史，出水庸介，花尻瑠理，袴塚高志
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] グアニンPNAモノマーの新規カチオン性アナログ2018
    • Author(s)
      杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 多様な官能基修飾を志向したヘリカルテンプレートペプチドの開発2018
    • Author(s)
      三澤隆史，諫田泰成，出水庸介
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 細胞膜高透過性ペプチドフォルダマーの開発と核酸デリバリーへの応用2018
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，出水庸介
    • Organizer
      第62回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] キラルな3員環状アミノ酸の合成と含有ペプチドのコンフォメーション解析2018
    • Author(s)
      古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
    • Organizer
      日本薬学会第138回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ペプチドリガンドを利用した標的タンパク質分解誘導剤の開発2018
    • Author(s)
      出水庸介，三澤隆史，大岡伸通，服部隆行，内藤幹彦
    • Organizer
      第 44 回反応と合成の進歩 シンポジウム
    • Data Source
      KAKENHI-PLANNED-18H05502

  • [Presentation] Development of cell-penetrating peptide foldamers for siRNA delivery2018
    • Author(s)
      Misawa, T., Ohoka, N., Oba, M., Tanaka, M., Naito, M., Demizu, Y.
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] PNA Oligomers Possessing PreQ1 as a Cationic Analogue of Guanine2018
    • Author(s)
      Toru Sugiyama, Hatsune Shibasaki, Shun-suke Moriya, Keiko Kuwata, Yasutada Imamura, Yosuke Demizu, Masaaki Kurihara, and Atsushi Kittaka
    • Organizer
      10th International Peptide Symposium
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06557

  • [Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017
    • Author(s)
      杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成2017
    • Author(s)
      古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
    • Organizer
      第54回化学関連支部合同九州大会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発2017
    • Author(s)
      小林寛幸，三澤隆史，内藤幹彦，出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids2017
    • Author(s)
      Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
    • Organizer
      Lindau Nobel Laureate Meetings 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] カチオン性プロリン誘導体を導入した細胞膜透過性ペプチドの開発2017
    • Author(s)
      小林寛幸，三澤隆史，内藤幹彦，出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析2017
    • Author(s)
      小林寛幸，三澤隆史，松野研司，出水庸介
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究2017
    • Author(s)
      古場百合恵，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発2017
    • Author(s)
      小林寛幸，三澤隆史，松野研司，出水庸介
    • Organizer
      第49回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製2017
    • Author(s)
      三澤隆史，出水庸介，栗原正明
    • Organizer
      日本ビタミン学会第69回大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究2017
    • Author(s)
      小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Peptide foldamers changing their conformations in response to low pH trigger2017
    • Author(s)
      古川かほり，大庭誠，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] カチオン性プロリン誘導体を含む細胞膜透過性ペプチドの開発2017
    • Author(s)
      小林寛幸，三澤隆史，松野研司，出水庸介
    • Organizer
      第49回若手ペプチド夏の勉強会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
    • Author(s)
      沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      仙台国際センター（宮城県仙台市）
    • Year and Date
      2017-03-25
    • Data Source
      KAKENHI-PROJECT-16K15121

  • [Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017
    • Author(s)
      栗原正明，三澤隆史，出水庸介
    • Organizer
      第3回Neo Vitamin D Workshop
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 二次構造に着目したカチオン性膜透過ペプチドの創製研究2017
    • Author(s)
      小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発2017
    • Author(s)
      小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
    • Organizer
      第47回複素環化学討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発2017
    • Author(s)
      大庭誠，古川かほり，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
    • Author(s)
      大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
    • Organizer
      2017年度生命科学系学会合同年次大会(ConBio2017)
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ジフェニルメタンを基本骨格とするリガンドの創製2017
    • Author(s)
      栗原正明，三澤隆史，出水庸介
    • Organizer
      第3回Neo Vitamin D Workshop
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造2017
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] カチオン性プロリン誘導体を含む細胞膜高透過性ペプチドの開発2017
    • Author(s)
      小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
    • Organizer
      第47回複素環化学討論会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 低pHに応答して二次構造を変化させるペプチドフォルダマーの開発2017
    • Author(s)
      大庭誠，古川かほり，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017
    • Author(s)
      三澤隆史，出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，栗原正明，出水庸介
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of post functionalizable oligopeptides as helical templates2017
    • Author(s)
      三澤隆史，出水庸介
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 小員環状ジ置換アミノ酸を用いたヘリカル二次構造の制御に関する研究2017
    • Author(s)
      古場百合恵，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of post functionalizable oligopeptides as helical templates2017
    • Author(s)
      三澤隆史，出水庸介
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures2017
    • Author(s)
      小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Peptide foldamers changing their conformations in response to low pH trigger2017
    • Author(s)
      古川かほり，大庭誠，遠山琴美，George Ouma Opiyo，出水庸介，栗原正明，土井光暢，田中正一
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発2017
    • Author(s)
      三澤隆史，小林寛幸，大庭誠，田中正一，栗原正明，出水庸介
    • Organizer
      第33回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖上にのみ不斉中心を持つ4員環状アミノ酸よりなるペプチドのヘリックス二次構造2017
    • Author(s)
      江藤諒，大庭誠，上田篤志，土井光暢，出水庸介，栗原正明，宇久翼，田中正一
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御に基づくペプチド創薬研究2017
    • Author(s)
      出水庸介，三澤隆史，栗原正明
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成2017
    • Author(s)
      沖津航陽，服部隆行，三澤隆史，栗原正明，内藤幹彦，出水庸介
    • Organizer
      ケミカルバイオロジー第12回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of helical cell penetrating peptides using non-proteinogenic amino acids2017
    • Author(s)
      Yamashita, H., Misawa, M., Kurihara, M., Demizu, Y.
    • Organizer
      Lindau Nobel Laureate Meetings 2017
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成2017
    • Author(s)
      池田光生，古場百合恵，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
    • Organizer
      第34回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御に基づくペプチド創薬研究2017
    • Author(s)
      出水庸介，三澤隆史，栗原正明
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 親水性分子の細胞内導入を志向した細胞膜高透過性ペプチドの開発2017
    • Author(s)
      三澤隆史，大岡伸通，大庭誠，田中正一，内藤幹彦，栗原正明，出水庸介
    • Organizer
      第15回次世代を担う有機化学シンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 正電荷を帯びたグアニン誘導体をもつPNAの合成2017
    • Author(s)
      杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，橘高敦史
    • Organizer
      第34回メディシナルケミストリーシンポジウム
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Hisタグ融合タンパク質分解誘導分子の設計と合成2017
    • Author(s)
      沖津航陽，服部隆行，三澤隆史，栗原正明，内藤幹彦，出水庸介
    • Organizer
      ケミカルバイオロジー第12回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究2017
    • Author(s)
      出水庸介，田中理恵，袴塚高志，栗原正明，花尻瑠理
    • Organizer
      日本法中毒学会第36回年会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] コンピュータシミュレーションによる違法薬物の活性予測に関する研究2017
    • Author(s)
      出水庸介，田中理恵，袴塚高志，栗原正明，花尻瑠理
    • Organizer
      日本法中毒学会第36回年会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides2017
    • Author(s)
      古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] キラルな三員環状ジ置換アミノ酸とそのペプチドの合成2017
    • Author(s)
      古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
    • Organizer
      第54回化学関連支部合同九州大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Development of cationic cell-penetrating peptides focused on their secondary structures2017
    • Author(s)
      小林寛幸，三澤隆史，大庭誠，田中正一，内藤幹彦，松野研司，出水庸介
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
    • Author(s)
      大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
    • Organizer
      2017年度生命科学系学会合同年次大会（ConBio2017）
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] Post-modification可能なα,α-ジ置換アミノ酸の合成と含有ペプチドの二次構造解析2017
    • Author(s)
      小林寛幸，三澤隆史，松野研司，出水庸介
    • Organizer
      第43回反応と合成の進歩シンポジウム
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 側鎖に不斉中心を有する三員環状ジ置換アミノ酸とそのペプチドの合成2017
    • Author(s)
      池田光生，古場百合恵，上田篤志，大庭誠，出水庸介，栗原正明，田中正一
    • Organizer
      第34回日本薬学会九州支部大会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
    • Author(s)
      大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
    • Author(s)
      大岡伸通，正田卓司，藤里卓磨，柴田識人，服部隆行，栗原正明，出水庸介，内藤幹彦
    • Organizer
      第76回日本癌学会学術総会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Synthesis of chiral three-membered ring α,α-disubstituted α-amino acid and conformational analysis of its peptides2017
    • Author(s)
      古場百合恵，池田光生，上田篤志，大庭誠，出水庸介，土井光暢，田中正一
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine2017
    • Author(s)
      杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] 二次構造制御を基盤とした膜透過性ペプチドの開発2017
    • Author(s)
      三澤隆史，小林寛幸，大庭誠，田中正一，栗原正明，出水庸介
    • Organizer
      第33回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Peptide nucleic acid possessing PreQ1 as a cationic analogue of guanine2017
    • Author(s)
      杉山亨，小原美咲，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
    • Organizer
      第54回ペプチド討論会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ヘリカルペプチドを用いたビタミンD受容体(VDR)―コアクチベータ相互作用阻害剤の創製2017
    • Author(s)
      三澤隆史，出水庸介，栗原正明
    • Organizer
      日本ビタミン学会第69回大会
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 多様な生理活性付与を志向した安定化ヘリカルテンプレートペプチドの開発2017
    • Author(s)
      三澤隆史，出水庸介
    • Organizer
      第61回日本薬学会関東支部大会
    • Data Source
      KAKENHI-PROJECT-17K08385

  • [Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの開発2016
    • Author(s)
      出水庸介，山下博子，三澤隆史，大庭誠，田中正一，栗原正明
    • Organizer
      第14回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2016-05-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エチレンアセタールを有するキラル5員環アミノ酸を含有するペプチドのヘリカル二次構造2016
    • Author(s)
      古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体分解誘導ペプチドの創製2016
    • Author(s)
      出水庸介，大岡伸通，三澤隆史，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ペプチド二次構造制御に基づく細胞膜高透過性ペプチドの創製2016
    • Author(s)
      出水庸介，山下博子，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
    • Organizer
      ケミカルバイオロジー第11回年会
    • Place of Presentation
      京都
    • Year and Date
      2016-06-15
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of helix-stabilized cell-penetrating peptides as an intracellular delivery tool2016
    • Author(s)
      Demizu, Y., Yamashita, H., Misawa, T., Oba, M., Tanaka, M., Kurihara, M.
    • Organizer
      34th European Peptide Symposium & 8th International Peptide Symposium
    • Place of Presentation
      Germany
    • Year and Date
      2016-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 二次構造制御を基軸とした膜透過ペプチドの創製研究2016
    • Author(s)
      出水庸介，三澤隆史，山下博子，大庭誠，田中正一，内藤幹彦，栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      つくば
    • Year and Date
      2016-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Hisタグタンパク質分解誘導分子の開発2016
    • Author(s)
      沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体分解活性を有するラロキシフェン誘導体の開発2016
    • Author(s)
      正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発2016
    • Author(s)
      山下博子，出水庸介，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 核内受容体を標的とした転写活性化阻害および分解誘導ペプチドの開2016
    • Author(s)
      出水庸介
    • Organizer
      第48回若手ペプチド夏の勉強会
    • Place of Presentation
      東京
    • Year and Date
      2016-07-31
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] デアザグアニン誘導体を持つPNAの合成2016
    • Author(s)
      杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Hisタグ融合タンパク質分解誘導分子の開発2016
    • Author(s)
      出水庸介，沖津航陽，服部隆行，三澤隆史，内藤幹彦，栗原正明
    • Organizer
      第42回反応と合成の進歩シンポジウム
    • Place of Presentation
      静岡
    • Year and Date
      2016-11-07
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 二次構造制御に基づく抗菌ペプチドフォルダマーの開発2016
    • Author(s)
      小澤佑斗，出水庸介，三澤隆史，菊池裕，栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016
    • Author(s)
      Naito, M., Hattori, T., Ohoka, N., Shibata, N., Shoda, T., Demizu, Y., Kurihara, M.
    • Organizer
      The 10th AACR-JCA Joint Conference
    • Place of Presentation
      Hawaii
    • Year and Date
      2016-02-16
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果2016
    • Author(s)
      三澤隆史，山下博子，加藤巧馬，服部隆行，大庭誠，田中正一，内藤幹彦，出水庸介，栗原正明
    • Organizer
      日本薬学会第136回年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 側鎖にグアニジノ基を有するプロリン誘導体の合成と細胞膜透過性ペプチドへの応用2016
    • Author(s)
      出水庸介，小林寛幸，山下博子，三澤隆史，大庭誠，田中正一，松野研司，栗原正明
    • Organizer
      第46回複素環化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2016-09-26
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Structure-activity relationship analysis of short helical peptides as VDR-coactivator interaction inhibitors2015
    • Author(s)
      Misawa, T., Demizu, Y., Kurihara, M.
    • Organizer
      第43回構造活性相関シンポジウム，第10回薬物の分子設計と開発に関する日中シンポジウム
    • Place of Presentation
      新潟
    • Year and Date
      2015-09-27
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ヘリカルペプチドを用いたビタミンD受容体（VDR）-コアクチベータ相互作用阻害剤の創製2015
    • Author(s)
      三澤隆史，出水庸介，栗原正明
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ジフェニルメタンを基本骨格としたエストロゲン受容体転写阻害剤および分解誘導剤の開発2015
    • Author(s)
      依岡桃子，三澤隆史，出水庸介，大岡伸通，槇島誠，南雲紳史，内藤幹彦，栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ジフェニルメタンを基本骨格とするエストロゲン受容体アンタゴニストの創製2015
    • Author(s)
      田中克哉，三澤隆史，出水庸介，諫田泰成，槇島誠，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体を標的とした転写活性化阻害および分解誘導ペプチドの創製2015
    • Author(s)
      出水庸介，三澤隆史，諫田泰成，大岡伸通，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] アルギニン含有ペプチドの細胞膜透過性とpDNAデリバリーに関する研究2015
    • Author(s)
      大庭誠，古川かほり，加藤巧馬，山下博子，出水庸介，栗原正明，田中正一
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 血管新生促進作用を有する新規2-クロル炭素環オキセタノシンA（COA-Cl）誘導体の創製2015
    • Author(s)
      榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ノンセコステロイド型VDRリガンドによるATRA耐性急性前骨髄球性白血病細胞の分化誘導2015
    • Author(s)
      野尻久雄，村田拓哉，橘高敦史，出水庸介，三澤隆史，栗原正明
    • Organizer
      第36回日本臨床薬理学会学術総会
    • Place of Presentation
      東京
    • Year and Date
      2015-12-09
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of His-tag fused protein degradation inducer based on protein knockdown strategy2015
    • Author(s)
      沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of helix-stabilized cationic peptides with cell-membrane penetrating ability2015
    • Author(s)
      山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of stabilized helical peptides and their functionalization2015
    • Author(s)
      Demizu, Y., Misawa, T., Kurihara, M.
    • Organizer
      13th International Kyoto Conference on New Aspects of Organic Chemistry
    • Place of Presentation
      京都
    • Year and Date
      2015-11-09
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] コンピュータシミュレーションによる合成カンナビノイドのCB1受容体への結合様式解析2015
    • Author(s)
      出水庸介，三澤隆史，内山奈穂子，花尻瑠理，袴塚高志，栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 新規トリアジン誘導体の合成とそれらの抗HIV-1活性評価2015
    • Author(s)
      榊原紀和，Gianfranco Balboni，Cenzo Congiu，Valentina Onnis，出水庸介，三澤隆史，栗原正明，加藤善久，丸山徳見，外山政明，岡本実佳，馬場昌範
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ノンセコステロイド型VDRリガンドの創製2015
    • Author(s)
      三澤隆史，出水庸介，槇島誠，栗原正明
    • Organizer
      第1回Neo Vitamin D Workshop
    • Place of Presentation
      滋賀
    • Year and Date
      2015-08-28
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of cell-penetrating fragment conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription2015
    • Author(s)
      Demizu, Y., Misawa, T., Kanda, Y., Sekino, Y., Kurihara, M.
    • Organizer
      The 11th Australian Peptide Conference 2015
    • Place of Presentation
      Australia
    • Year and Date
      2015-10-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体転写阻害剤および分解誘導剤の創製2015
    • Author(s)
      依岡桃子，三澤隆史，出水庸介，大岡伸通，諫田泰成，槇島誠，南雲紳史，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Development of helical peptide as inhibitors of estrogen receptor-mediated transcription2015
    • Author(s)
      出水庸介，三澤隆史，諫田泰成，大岡伸通，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 長鎖アルキルを有するノンセコステロイド型VDRリガンドの創製2015
    • Author(s)
      三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Hisタグタンパク質応答性蛍光プローブの開発2015
    • Author(s)
      沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Estrogen induces proliferation of breast cancer stem cells via NO/sGC/cGMP signaling pathway2015
    • Author(s)
      Hirata, N.; Demizu, Y.; Kurihara, M.; Sekino, Y.; Kanda, Y.
    • Organizer
      第13回幹細胞シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2015-05-29
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Design and synthesis of short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015
    • Author(s)
      三澤隆史，出水庸介，栗原正明
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Structural development of stapled short helical peptides as vitamin D receptor (VDR)-coactivator interaction inhibitors2015
    • Author(s)
      Misawa, T., Demizu, Y., Kurihara, M.
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲンによるNOを介した乳癌幹細胞の増殖2015
    • Author(s)
      平田尚也，山田茂，出水庸介，栗原正明，関野祐子，諫田泰成
    • Organizer
      第132回日本薬理学会関東部会
    • Place of Presentation
      千葉
    • Year and Date
      2015-07-04
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ラロキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発2015
    • Author(s)
      正田卓司，加藤雅士，藤里卓磨，三澤隆史，出水庸介，井上英史，内藤幹彦，栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 血管新生促進剤を指向した2-クロル炭素環オキセタノシンA（COA-Cl）の新規誘導体の創製研究2015
    • Author(s)
      榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
    • Organizer
      第54回薬学会中国四国支部学術大会
    • Place of Presentation
      高知
    • Year and Date
      2015-10-31
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体転写活性化阻害能を有するヘリカルペプチドの開発2015
    • Author(s)
      出水庸介，三澤隆史，長久保貴哉，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
    • Organizer
      ケミカルバイオロジー第10回年会
    • Place of Presentation
      宮城
    • Year and Date
      2015-06-10
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 修飾デアザグアニン含有PNAオリゴマーの合成2015
    • Author(s)
      杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] グアニジノ基を有する環状アミノ酸の合成と細胞膜透過性ペプチドへの応用2015
    • Author(s)
      出水庸介，山下博子，三澤隆史，大庭誠，田中正一，栗原正明
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発2015
    • Author(s)
      山下博子，出水庸介，三澤隆史，大庭誠，田中正一，服部隆行，内藤幹彦，栗原正明
    • Organizer
      第31回日本DDS学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2015-07-02
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用2015
    • Author(s)
      山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
    • Organizer
      第41回反応と合成の進歩シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2015-10-26
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Design, synthesis and evaluation of tamoxifen derivatives as new selective estrogen receptor down-regulators2015
    • Author(s)
      Shoda, T., Kato, M., Okuhira, K., Demizu, Y., Inoue, H., Naito, M., Kurihara, M.
    • Organizer
      PACIFICHEM 2015
    • Place of Presentation
      Hawaii
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 長鎖アルキル基を有するビタミンD受容体リガンドの創製2015
    • Author(s)
      三澤隆史，依岡桃子，出水庸介，大岡伸通，木下恵愛，槇島誠，内藤幹彦，栗原正明
    • Organizer
      第59回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2015-09-12
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ノンセコステロイド型ビタミンD受容体リガンドの創製―官能基変換による活性制御―2015
    • Author(s)
      三澤隆史，依岡桃子，出水庸介，谷内出友美，大岡伸通，木下恵愛，野尻久雄，橘高敦史，槇島誠，内藤幹彦，栗原正明
    • Organizer
      第33回メディシナルケミストリーシンポジウム
    • Place of Presentation
      千葉
    • Year and Date
      2015-11-25
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Cell-penetrating ability and plasmid DNA delivary using fluorescein-labeled arginine-rich peptides2015
    • Author(s)
      Oba, M., Furukawa, K., Kato, T., Demizu, Y., Yamashita, H., Kurihara, M., Tanaka, M.
    • Organizer
      The 11th Australian Peptide Conference 2015
    • Place of Presentation
      Australia
    • Year and Date
      2015-10-25
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Synthesis of PNA oligomers containing modified deazaguanines for the development of functional PNA2015
    • Author(s)
      杉山亨，桑田啓子，今村保忠，出水庸介，栗原正明，高野真史，橘高敦史
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Conformational analysis of peptides composed of chiral cyclic amino acids2015
    • Author(s)
      古場百合恵，上田篤志，大庭誠，土井光暢，出水庸介，栗原正明，田中正一
    • Organizer
      第52回ペプチド討論会
    • Place of Presentation
      神奈川
    • Year and Date
      2015-11-16
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 2-クロル炭素環オキセタノシンA (COA-Cl)の新規誘導体の合成とその血管新生促進作用2015
    • Author(s)
      榊原紀和，五十嵐淳介，高田麻紀，出水庸介，三澤隆史，栗原正明，小西良士，加藤善久，丸山徳見，塚本郁子
    • Organizer
      第45回複素環化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2015-11-19
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 細胞内Hisタグタンパク質応答性蛍光プローブの開発2014
    • Author(s)
      沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体分解誘導剤による乳癌の細胞死誘導分子機構2014
    • Author(s)
      奥平桂一郎，出水庸介，服部隆行，大岡伸通，柴田識人，最上（西巻）知子，栗原正明，奥田晴宏，内藤幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25430164

  • [Presentation] エストロゲン受容体転写阻害ペプチドの創製2014
    • Author(s)
      長久保貴哉，出水庸介，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25430164

  • [Presentation] Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells2014
    • Author(s)
      Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      米国ビッグスカイ
    • Data Source
      KAKENHI-PROJECT-25430164

  • [Presentation] エストロゲン受容体転写阻害能を有するペプチドの創製2014
    • Author(s)
      長久保貴哉，出水庸介，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 合成カンナビノイドのCB1受容体に対する結合様式解析に関する研究2014
    • Author(s)
      出水庸介，三澤隆史，内山奈穂子，花尻瑠理，袴塚高志，栗原正明
    • Organizer
      第58回日本薬学会関東支部大会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-04
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] LXXLL モチーフを有する安定化ヘリカルペプチド2013
    • Author(s)
      白川真奈美,名児耶早織,出水庸介,正 田卓司,佐藤由紀子,栗原正明
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] らせん構造を有する新規フォルダマーの創製2013
    • Author(s)
      山崎徳和,出水庸介,正田卓司,佐藤由 紀子,栗原正明
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] SNIPER induces ubiquitylation and proteasomal degradation of estrogen receptor followed by rapid cell death in breast cancer cells2013
    • Author(s)
      Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M
    • Organizer
      The 35th Naito Conference; The Ubiquitin-Proteasome System
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-25430164

  • [Presentation] 安定化ヘリカルペプチドを用いたVDR-コアクチベータ結合阻害剤の創製2013
    • Author(s)
      名児耶早織,出水庸介,佐藤由紀子,正 田卓司,土井光暢,田中正一,栗原正明
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013
    • Author(s)
      Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami, T, Okuda H, Kurihara M, Naito M
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      米国ボストン
    • Data Source
      KAKENHI-PROJECT-25430164

  • [Presentation] ジ置換アミノ酸によるLD-ペプチドの二次構造制御2013
    • Author(s)
      出水庸介,土井光暢,佐藤由紀子,田中 正一,栗原正明
    • Organizer
      日本薬学会第133 年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] 安定化ヘリカルペプチドを用いたビタミンD 受容体転写阻害剤の創製2012
    • Author(s)
      名児耶早織,出水庸介,山縣奈々子,佐 藤由紀子,土井光暢,田中正一,栗原正 明
    • Organizer
      日本薬学会第132 年会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] 安定化ヘリカルペプチドを用いたVDR 転写阻害剤の設計と合成2012
    • Author(s)
      名児耶早織,出水庸介,佐藤由紀子,土 井光暢,田中正一,栗原正明
    • Organizer
      日本ケミカルバイオロジー学会 第7回年会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] 安定化ヘリカルペプチドを用いたα,β-不飽和ケトンの不斉エポキシ化2011
    • Author(s)
      出水庸介,名児耶早織,佐藤由紀子,奥 田晴宏,栗原正明,土井光暢,田中正一
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      徳島
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Design of Stabilized α-Helical Peptides for Transcriptional Inhibitor of Nuclear Receptor2011
    • Author(s)
      S. Nagoya, Y. Demizu, Y. Sato, M. Doi, M. Tanaka, H. Okuda, M. Kurihara
    • Organizer
      AIMECS11
    • Place of Presentation
      Tokyo
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Design of a stabilized helical peptides and its application2011
    • Author(s)
      M. Kurihara, Y. Demizu, N. Yamagata, Y. Sato, Y. Takeuchi, M. Doi, M. Tanaka, H. Okuda
    • Organizer
      22nd American peptide symposium
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] ヘリカルペプチドの制御とカルコン類の不斉エポキシ化への応用2011
    • Author(s)
      出水庸介,山縣奈々子,佐藤由紀子,土 井光暢,田中正一,奥田 晴宏,栗原 正 明
    • Organizer
      日本薬学会第131 年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Design of non-secosteroidal VDR ligands and binding mode to VDR-LBD2011
    • Author(s)
      Y.Demizu
    • Organizer
      4^<th> European Conference on Chemisitry for Life Sciences
    • Place of Presentation
      Budapest, Hungary
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] ノンセコ型VDRリガンドの創製およびVDRとの相互作用解析2011
    • Author(s)
      出水庸介
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Controlling helical peptides containing equal numbers of L- and D-amino acids2011
    • Author(s)
      Y.Demizu
    • Organizer
      22^<nd> American peptide symposium
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] ステープルペプチドを用いたα,β-不飽和ケトンの不斉エポキシ化2011
    • Author(s)
      出水庸介
    • Organizer
      第55回日本薬学会関東支部大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] ヘリカルペプチドの制御とカルコン類の不斉エポキシ化への応用2011
    • Author(s)
      出水庸介, 山縣奈々子, 佐藤由紀子, 土井光暢, 田中正一, 奥田晴宏, 栗原正明
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Design of Stapled Helical Peptides for Catalyic Eenantioselective Epoxidation of α,α-Unsaturated Ketones2011
    • Author(s)
      出水庸介
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Controlling the helical screw sense of Aib-based peptides with chiral α-amino acids2010
    • Author(s)
      Y.Demizu
    • Organizer
      PACIFICHEM 2010
    • Place of Presentation
      ハワイ
    • Year and Date
      2010-12-18
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Controlling the helical screw sense of Aib-based peptides with chiral a-amino acids2010
    • Author(s)
      Demizu, Y., Sato, Y., Tanaka, M, Doi, M, Suemune, H, Okuda, H, Kurihara, M
    • Organizer
      PACIFICHEM 2010
    • Place of Presentation
      Honolulu, USA
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] ヘリカルオリゴマーによるα,β-不飽和ケトンの不斉エポキシ化2010
    • Author(s)
      出水庸介, 田中正一
    • Organizer
      「協奏機能触媒」第7回公開シンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Development of non-secosteroidal VDR ligands2010
    • Author(s)
      Demizu, Y, Sato, Y, Ochiai, E, Horie, K, Kakua, S, Takimoto-Kamimura, M, Okuda, H, Kurihara, M
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
    • Author(s)
      Y.Demizu
    • Organizer
      31st European Peptide Symposium
    • Place of Presentation
      デンマーク
    • Year and Date
      2010-09-07
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Conformational studies of diastereomeric-Leu-Aib-peptides2010
    • Author(s)
      Demizu, Y., Doi, M., Sato, Y., Tanaka, M., Okuda, H., Kurihara, M
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Conformational studies of diastereomeric -Leu-Aib- peptides2010
    • Author(s)
      Y.Demizu
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      京都
    • Year and Date
      2010-12-06
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Conformational studies of diastereomeric-Leu-Aib-peptides2010
    • Author(s)
      Y.Demizu
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
    • Author(s)
      Demizu, Y, Doi, M, Sato, Y, Tanaka, M, Okuda, H Kurihara, M
    • Organizer
      31st European Peptide Symposium
    • Place of Presentation
      Copenhagen, Denmark
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Development of non-secosteroidal VDR ligands2010
    • Author(s)
      Y.Demizu
    • Organizer
      The 21st French-Japanese Symposium on Medicinal and Fine Chemistry
    • Place of Presentation
      京都
    • Year and Date
      2010-05-10
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] C末端バリンによるヘリカル二次構造の制御2010
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] ノンセコVDRリガンドの創製と結合様式の解析2010
    • Author(s)
      出水庸介
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-17
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] 新たな水素結合ネットワークを指向したVDRリガンド2010
    • Author(s)
      出水庸介, 佐藤由紀子, 竹内由起, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] ノンセコVDRリガンドの創製と結合様式の解析2010
    • Author(s)
      出水庸介, 佐藤由紀子, 落合鋭士, 堀江恭平, 高木健一郎, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] C末端バリンによるヘリカル二次構造の制御2010
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山桃太郎アリーナ(岡山)
    • Year and Date
      2010-03-28
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] C末端バリンによるヘリカル二次構造の制御2010
    • Author(s)
      出水庸介, 佐藤由紀子, 土井光暢, 田中正一, 奥田晴宏, 栗原正明
    • Organizer
      日本薬学会第130回年会
    • Place of Presentation
      岡山
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences2010
    • Author(s)
      Y.Demizu
    • Organizer
      31'st European Peptide Symposium
    • Place of Presentation
      Copenhagen
    • Data Source
      KAKENHI-PROJECT-22590114

  • [Presentation] 新たな水素結合ネットワークを指向したVDRリガンド2010
    • Author(s)
      出水庸介
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-18
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] 水溶性キラル環状α,α-ジ置換アミノ酸およびペプチドの合成とコンフォメーション解析2009
    • Author(s)
      出水庸介
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州国際会議場(福岡)
    • Year and Date
      2009-11-04
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] ノンセコステロイド型VDRリガンドのデノボ設計2009
    • Author(s)
      出水庸介, 金子文也, 岩井すみれ, 高橋健男, 佐藤由紀子, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] ノンセコステロイド型VDRリガンドの設計と合成2009
    • Author(s)
      出水庸介
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京大学(東京)
    • Year and Date
      2009-11-25
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] 水溶性キラル環状α,α-ジ置換アミノ酸およびペプチドの合成とコンフォメーション解析2009
    • Author(s)
      出水庸介, 田中正一, 末宗洋, 土井光暢, 佐藤由紀子, 奥田晴宏, 栗原正明
    • Organizer
      第46回ペプチド討論会
    • Place of Presentation
      北九州
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] ノンセコステロイド型VDRリガンドのデノボ設計2009
    • Author(s)
      出水庸介
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢市文化ホール(石川)
    • Year and Date
      2009-11-16
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] ノンセコステロイド型VDRリガンドの設計と合成2009
    • Author(s)
      出水庸介, 金子文也, 岩井すみれ, 高橋健男, 佐藤由紀子, 落合鋭士, 堀江恭平, 角田真二, 上村みどり, 奥田晴宏, 栗原正明
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-21790018

  • [Presentation] Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them2008
    • Author(s)
      Demizu, Y.; Shiigi, H.; Mori, H.; Matsumoto, K.; Matsumura, Y.; Onomura, O
    • Organizer
      213th ECS Meeting
    • Place of Presentation
      Phoenix
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] Chiral azabicyclo-N-oxyls and asymmetric oxidation of secondary alcohols mediated by them2008
    • Author(s)
      Demizu, Y. et al.
    • Organizer
      The 213th ECS Meeting
    • Place of Presentation
      Phoenix, USA
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] 分子認識に基づくアルコール類の不斉トシル化2008
    • Author(s)
      出水庸介, ,満田勝, 松本和也, 松村功啓, 尾野村治
    • Organizer
      日本薬学会第128年会
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] 新規キラルN-オキシルを用いる二級アルコールの不斉電極酸化2007
    • Author(s)
      出水庸介
    • Organizer
      第31回有機電子移動化学討論会
    • Place of Presentation
      鳥取
    • Year and Date
      2007-06-14
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] Electrochemical oxidation of alcohols catalyzed by new organic mediators2007
    • Author(s)
      Demizu, Y.
    • Organizer
      211th ECS Meeting
    • Place of Presentation
      アメリカ
    • Year and Date
      2007-05-11
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] 新規キラルN-オキシンを用いる二級アルコールの不斉電極酸化2007
    • Author(s)
      出水庸介, 末続肇, 尾野村治, 松村功啓
    • Organizer
      第31回有機電子移動化学討論会
    • Place of Presentation
      鳥取
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] 分子認識に基づくキラル銅触媒を用いたアルコール類の不斉トシル化2007
    • Author(s)
      出水庸介
    • Organizer
      第1回若手交流合宿セミナー
    • Place of Presentation
      福岡
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] 分子認識に基づくアルコール類の不斉トシル化2007
    • Author(s)
      出水庸介
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2007-03-26
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] Electrochemical oxidation of alcohols catalyzed by new organic mediators2007
    • Author(s)
      Demizu, Y.; Oda, T.; Onomura, O.; Matsumura, Y
    • Organizer
      211th ECS Meeting
    • Place of Presentation
      Chicago
    • Data Source
      KAKENHI-PROJECT-19790017

  • [Presentation] Synthesis and conformational analysis of helical oligomers with a changeable chiral acetal moiety
    • Author(s)
      江藤諒，大庭誠，上田篤志，石川奈保子，栗原正明，出水庸介，末宗洋，土井光暢，田中正一
    • Organizer
      第51回ペプチド討論会
    • Place of Presentation
      徳島
    • Year and Date
      2014-10-22 – 2014-10-24
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] HIV-1剤を指向した1-置換型ウラシル誘導体および尿素誘導体の創製研究
    • Author(s)
      榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
    • Organizer
      第52回薬学会中国四国支部学術大会
    • Place of Presentation
      愛媛
    • Year and Date
      2014-10-26 – 2014-10-27
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 三重螺旋構造の安定化を指向したβ-ペプチド導入型コラーゲン模倣物の創製
    • Author(s)
      杖本望，出水庸介，百合野翔太郎，中村陽菜，土井麻緒，栗原正明，須原義智
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 抗ウィルス薬を目指した新規O-硫酸化多糖類の合成
    • Author(s)
      岡崎優祐，出水庸介，細谷翼，川口潤一郎，栗原正明，須原義智
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 3,5-ジメチルベンジル基を有するウラシル誘導体および尿素誘導体の合成とそれらの抗HIV-1活性評価
    • Author(s)
      榊原紀和，馬場昌範，岡本実佳，外山政明，出水庸介，三澤隆史，栗原正明，入江晃司，加藤善久，丸山徳見
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Helical secondary structures of peptides having chiral cyclic amino acid with two azido functional groups
    • Author(s)
      Tanaka, M., Takazaki, H., Kawabe, N., Doi, M., Demizu, Y., Kurihara, M., Suemune, H., Oba, M.
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-08-31 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] VDR-コアクチベータ結語阻害作用を有するステープルペプチドの創製
    • Author(s)
      川村愛，出水庸介，三澤隆史，栗原正明
    • Organizer
      ケミカルバイオロジー第9回年会
    • Place of Presentation
      大阪
    • Year and Date
      2014-06-12 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体転写阻害ペプチドの開発
    • Author(s)
      出水庸介，長久保貴哉，三澤隆史，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] ヘリカルペプチドを用いたエストロゲン受容体転写阻害剤の創製
    • Author(s)
      三澤隆史，長久保貴哉，出水庸介，佐藤由紀子，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
    • Organizer
      第32回メディシナルケミストリーシンポジウム
    • Place of Presentation
      神戸
    • Year and Date
      2014-11-26 – 2014-11-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 細胞内タンパク質に対する蛍光スイッチング機能を持つ小分子プローブの開発
    • Author(s)
      沖津航陽，出水庸介，三澤隆史，正田卓司，服部隆行，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 二次構造制御に基づく膜透過性ヘリカルペプチドの創製
    • Author(s)
      山下博子，出水庸介，三澤隆史，大庭誠，田中正一，栗原正明
    • Organizer
      第40回反応と合成の進歩シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2014-11-10 – 2014-11-11
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] エストロゲン受容体転写活性化阻害ペプチドの創製
    • Author(s)
      出水庸介，長久保貴哉，三澤隆史，諫田泰成，奥平桂一郎，関野祐子，内藤幹彦，栗原正明
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Stapled short helical peptides for vitamin D receptor-coactivator interaction inhibitor
    • Author(s)
      Kurihara, M., Kawamura, M., Misawa, T., Sato, Y., Demizu, Y.
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-08-31 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] Conformations of LD-peptides containing equal amounts of L-amino acids, D-amino acids, and achiral α,α-disubstitued amino acids
    • Author(s)
      Demizu, Y., Misawa, T., Yamashita, H., Doi, M., Sato, Y., Tanaka, M., Kurihara
    • Organizer
      33rd European Peptide Symposium
    • Place of Presentation
      ブルガリア
    • Year and Date
      2014-08-31 – 2014-09-05
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] リパーゼ触媒を用いた[5]ヘリセン類の速度論的光学分割
    • Author(s)
      清水貴士，山本耕介，メイビョウ，出水庸介，栗原正明，末宗洋，臼井一晃
    • Organizer
      日本薬学会第135回年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-26 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-26460169

  • [Presentation] 二次構造制御に基づくカチオン性膜透過ペプチドの開発
    • Author(s)
      山下博子,