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Okuhira Keiichiro  奥平 桂一郎

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OKUHIRA Keiichiro  奥平 桂一郎

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Researcher Number 10425671
Other IDs
Affiliation (Current) 2022: 大阪医科薬科大学, 薬学部, 教授
Affiliation (based on the past Project Information) *help 2021 – 2022: 大阪医科薬科大学, 薬学部, 教授
2020: 大阪薬科大学, 薬学部, 教授
2018 – 2019: 徳島大学, 大学院医歯薬学研究部(薬学域), 准教授
2016 – 2017: 徳島大学, 大学院医歯薬学研究部(薬学系), 准教授
2015 – 2016: 徳島大学, 大学院医歯薬学研究部, 准教授 … More
2014: 徳島大学, ヘルスバイオサイエンス研究部, 准教授
2013: 国立医薬品食品衛生研究所, 機能生化学部, 室長
2008 – 2012: National Institute of Health Sciences, 機能生化学部, 主任研究官
2011: 国立医薬品食品衛生研究所, 機能生化学部, 研究員
2007: National Institute of Health Sciences, 機能生化学部, 研究員
2006: 国立医薬品食品衛生研究所, 代謝生化学部, 研究員 Less
Review Section/Research Field
Principal Investigator
Biological pharmacy / Tumor therapeutics / Basic Section 59040:Nutrition science and health science-related
Except Principal Investigator
Environmental pharmacy / Basic Section 63040:Environmental impact assessment-related / Basic Section 54040:Metabolism and endocrinology-related
Keywords
Principal Investigator
脂質 / 動脈硬化 / シグナル伝達 / 神経 / 乳癌 / エストロゲン受容体 / エストロゲンレセプター / 薬学 / リポタンパク質 / HDL … More / 高密度リポ蛋白質 / 高密度リポタンパク質 / アポリポタンパク質 / アポリポタンタンパク質 … More
Except Principal Investigator
ナノ材料 / カーボンナノチューブ / コレステロール / インフラマソーム / IL-1β / NLRP3 / IL-1beta / 環境 / エピジェネティクス / 大気 / 遊離コレステロール / SR-BI / HDL Less
  • Research Projects

    (10 results)
  • Research Products

    (108 results)
  • Co-Researchers

    (40 People)
  •  Studies on novel HDL cholesterol efflux mechanisms

    • Principal Investigator
      辻田 麻紀
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 54040:Metabolism and endocrinology-related
    • Research Institution
      Nagoya City University
  •  動脈硬化治療法の確立に向けたHDLリモデリングの分子基盤の解明とその応用Principal Investigator

    • Principal Investigator
      奥平 桂一郎
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 59040:Nutrition science and health science-related
    • Research Institution
      Osaka Medical and Pharmaceutical University
      Osaka University of Pharmaceutical Sciences
  •  Seasonal fluctuation and regional characteristics of epigenetic induction via miRNA by airborne particles

    • Principal Investigator
      長谷井 友尋
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 63040:Environmental impact assessment-related
    • Research Institution
      Osaka University of Pharmaceutical Sciences
  •  動脈硬化治療に向けたapoA-I/HDL結合タンパク質の機能解明研究(国際共同研究強化)Principal Investigator

    • Principal Investigator
      奥平 桂一郎
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Fund for the Promotion of Joint International Research (Fostering Joint International Research)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokushima
  •  Elucidation of the mechanism for acivity regulation of HDL-interacting proteinsPrincipal Investigator

    • Principal Investigator
      OKUHIRA Keiichiro
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Biological pharmacy
    • Research Institution
      The University of Tokushima
  •  Development of estrogen receptor degrader and analysis of drug-induced cell death mechanism for breast cancer therapyPrincipal Investigator

    • Principal Investigator
      OKUHIRA Keiichiro
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Tumor therapeutics
    • Research Institution
      The University of Tokushima
      National Institute of Health Sciences
  •  Control of multiwall carbon nanotube-induced inflammatory responses by cellular cholesterol

    • Principal Investigator
      NISHIMAKI-MOGAMI Tomoko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  A novel potential mechanism for the transcriptional regulation by ABCA1Principal Investigator

    • Principal Investigator
      OKUHIRA Keiichiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  The function and regulation of ABCA1 in neuronPrincipal Investigator

    • Principal Investigator
      OKUHIRA Keiichiro
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences
  •  ABCA1と相互作用する新規蛋白質のHDL形成における機能の解明Principal Investigator

    • Principal Investigator
      奥平 桂一郎
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      National Institute of Health Sciences

All 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article Presentation Patent

  • [Journal Article] Albumin domain mutants with enhanced Aβ binding capacity identified by phage display analysis for application in various peripheral Aβ elimination approaches of Alzheimer's disease treatment2020

    • Author(s)
      Ishima Yu、Mimono Ai、Tuan Giam Chuang Victor、Fukuda Tetsuya、Kusumoto Kohshi、Okuhira Keiichiro、Suwa Yoshiaki、Watanabe Hiroshi、Ishida Tatsuhiro、Morioka Hiroshi、Maruyama Toru、Otagiri Masaki
    • Journal Title

      IUBMB Life.

      Volume: 72 Pages: 641-651

    • DOI

      10.1002/iub.2203

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06810, KAKENHI-PROJECT-18H02587, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-20H04124
  • [Journal Article] Apolipoprotein A‐I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high‐density lipoproteins assembled by ABCA1 and LCAT2020

    • Author(s)
      Tsujita Maki、Vaisman Boris、Chengyu Liu、Vickers Kasey C.、Okuhira Kei‐ichiro、Braesch‐Andersen Sten、Remaley Alan T.
    • Journal Title

      FEBS Letters

      Volume: 595 Pages: 773-788

    • DOI

      10.1002/1873-3468.13950

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20H04124
  • [Journal Article] Sequence-Independent Traceless Method for Preparation of Peptide/Protein Thioesters Using CPaseY-Mediated Hydrazinolysis2020

    • Author(s)
      Ueda Masahiro、Komiya Chiaki、Arii Sayuki、Kusumoto Kohshi、Denda Masaya、Okuhira Keiichiro、Shigenaga Akira、Otaka Akira
    • Journal Title

      CHEMICAL & PHARMACEUTICAL BULLETIN

      Volume: 68 Issue: 12 Pages: 1226-1232

    • DOI

      10.1248/cpb.c20-00674

    • NAID

      130007948412

    • ISSN
      0009-2363, 1347-5223
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K21483, KAKENHI-PROJECT-20H04124
  • [Journal Article] Cancer cell-type tropism is one of crucial determinants for the efficient systemic delivery of cancer cell-derived exosomes to tumor tissues2019

    • Author(s)
      Emam Sherif E.、Abu Lila Amr Selim、Elsadek Nehal E.、Ando Hidenori、Shimizu Taro、Okuhira Keiichiro、Ishima Yu、Mahdy Mahmoud A.、Ghazy Fakhr-eldin S.、Ishida Tatsuhiro
    • Journal Title

      European Journal of Pharmaceutics and Biopharmaceutics

      Volume: 145 Pages: 27-34

    • DOI

      10.1016/j.ejpb.2019.10.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Journal Article] Distribution of polysulfide in human biological fluids and their association with amylase and sperm activities2019

    • Author(s)
      Ikeda Mayumi、Ishima Yu、Chuang Victor T. G.、Sakai Maki、Osafune Hiroki、Ando Hidenori、Shimizu Taro、Okuhira Keiichiro、Watanabe Hiroshi、Maruyama Toru、Otagiri Masaki、Akaike Takaaki、Ishida Tatsuhiro
    • Journal Title

      Molecules

      Volume: 24 Pages: 1689-1689

    • DOI

      10.3390/molecules24091689

    • NAID

      120006995454

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02587, KAKENHI-PROJECT-18H02604, KAKENHI-PROJECT-18J10935, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18H05277
  • [Journal Article] A Photo-Activatable Peptide Mimicking Functions of Apolipoprotein A-I2019

    • Author(s)
      Haruka Kawahara, Naoki Miyashita, Kohki Tachibana, Yusuke Tsuda, Kyohei Morimoto, Kouhei Tsuji, Akira Shigenaga, Akira Otaka, Tatsuhiro Ishida and Keiichiro Okuhira
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 42 Issue: 6 Pages: 1019-1024

    • DOI

      10.1248/bpb.b19-00114

    • NAID

      130007657697

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16K08236
  • [Journal Article] A simplified method for manufacturing RNAi therapeutics for local administration2019

    • Author(s)
      Ando Hidenori、Abu Lila Amr S.、Fukushima Masakazu、Matsuoka Rie、Shimizu Taro、Okuhira Keiichiro、Ishima Yu、Huang Cheng-Long、Wada Hiromi、Ishida Tatsuhiro
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 564 Pages: 256-262

    • DOI

      10.1016/j.ijpharm.2019.04.054

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor alpha degradation.2018

    • Author(s)
      Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
    • Journal Title

      J Biol Chem

      Volume: 293 Pages: 6776-6790

    • DOI

      10.1074/jbc.ra117.001091

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
  • [Journal Article] Effect of Phosphatidylserine and Cholesterol on Membrane-mediated Fibril Formation by the N-terminal Amyloidogenic Fragment of Apolipoprotein A-I2018

    • Author(s)
      Mizuguchi Chiharu、Nakamura Mitsuki、Kurimitsu Naoko、Ohgita Takashi、Nishitsuji Kazuchika、Baba Teruhiko、Shigenaga Akira、Shimanouchi Toshinori、Okuhira Keiichiro、Otaka Akira、Saito Hiroyuki
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 5497-5497

    • DOI

      10.1038/s41598-018-23920-3

    • NAID

      120006535031

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H02611, KAKENHI-PROJECT-16J01828, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-17H03979, KAKENHI-PROJECT-17K19492, KAKENHI-PROJECT-17K16123
  • [Journal Article] Reactivity of IgM antibodies elicited by PEGylated liposomes or PEGylated lipoplexes against auto and foreign antigens2018

    • Author(s)
      8.Ando, H., Abu Lila, A.S., Kawanishi, M., Shimizu, T., Okuhira, K., Ishima, Y., Ishida, T.
    • Journal Title

      Journal of Controlled Release

      Volume: 270 Pages: 114-119

    • DOI

      10.1016/j.jconrel.2017.12.002

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04639, KAKENHI-PROJECT-16K15108, KAKENHI-PROJECT-16K08236
  • [Journal Article] A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes2018

    • Author(s)
      Shimizu Taro、Abu Lila Amr S.、Fujita Risako、Awata Mizuki、Kawanishi Munehira、Hashimoto Yosuke、Okuhira Keiichiro、Ishima Yu、Ishida Tatsuhiro
    • Journal Title

      European Journal of Pharmaceutics and Biopharmaceutics

      Volume: 127 Pages: 142-149

    • DOI

      10.1016/j.ejpb.2018.02.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-17J03990
  • [Journal Article] A Novel Platform for Cancer Vaccines: Antigen-Selective Delivery to Splenic Marginal Zone B Cells via Repeated Injections of PEGylated Liposomes2018

    • Author(s)
      Shimizu Taro、Abu Lila Amr S.、Kawaguchi Yoshino、Shimazaki Yuna、Watanabe Yuki、Mima Yu、Hashimoto Yosuke、Okuhira Keiichiro、Storm Gert、Ishima Yu、Ishida Tatsuhiro
    • Journal Title

      The Journal of Immunology

      Volume: 201 Pages: 2969-2976

    • DOI

      10.4049/jimmunol.1701351

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-17J03990
  • [Journal Article] Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways2018

    • Author(s)
      Emam Sherif E.、Ando Hidenori、Lila Amr S. Abu、Shimizu Taro、Okuhira Keiichiro、Ishima Yu、Mahdy Mahmoud A.、Ghazy Fakhr-eldin S.、Sagawa Ikuko、Ishida Tatsuhiro
    • Journal Title

      Scientific Reports

      Volume: 8 Pages: 14493-14493

    • DOI

      10.1038/s41598-018-32861-w

    • NAID

      120006875666

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Journal Article] A Cell Assay for Detecting Anti-PEG Immune Response against PEG-Modified Therapeutics2018

    • Author(s)
      Shimizu Taro、Abu Lila Amr S.、Awata Mizuki、Kubo Yukiyo、Mima Yu、Hashimoto Yosuke、Ando Hidenori、Okuhira Keiichiro、Ishima Yu、Ishida Tatsuhiro
    • Journal Title

      Pharmaceutical research

      Volume: 35 Pages: 223-223

    • DOI

      10.1007/s11095-018-2505-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-17J03990
  • [Journal Article] A Novel Strategy to Increase the Yield of Exosomes (Extracellular Vesicles) for an Expansion of Basic Research2018

    • Author(s)
      Emam Sherif E.、Ando Hidenori、Abu Lila Amr Selim、Shimizu Taro、Ukawa Masami、Okuhira Keiichiro、Ishima Yu、Mahdy Mahmoud A.、Ghazy Fakhr-eldin S.、Ishida Tatsuhiro
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 41 Issue: 5 Pages: 733-742

    • DOI

      10.1248/bpb.b17-00919

    • NAID

      130006730692

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Journal Article] Intratumoral Visualization of Oxaliplatin within a Liposomal Formulation Using X-ray Fluorescence Spectrometry2018

    • Author(s)
      5.Ando, H., Abu Lila, A.S., Tanaka, M., Doi, Y., Terada, Y., Yagi, N., Shimizu, T., Okuhira, K., Ishima, Y., Ishida, T.,
    • Journal Title

      Molecular Pharmaceutics

      Volume: 15 Pages: 403-409

    • DOI

      10.1021/acs.molpharmaceut.7b00762

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04639, KAKENHI-PROJECT-16K08236
  • [Journal Article] Doxorubicin Expands <i>in Vivo</i> Secretion of Circulating Exosome in Mice2018

    • Author(s)
      Emam Sherif E.、Ando Hidenori、Abu Lila Amr Selim、Kobayashi Shinya、Shimizu Taro、Okuhira Keiichiro、Ishima Yu、Ishida Tatsuhiro
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 41 Issue: 7 Pages: 1078-1083

    • DOI

      10.1248/bpb.b18-00202

    • NAID

      130007387206

    • ISSN
      0918-6158, 1347-5215
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Journal Article] Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules2017

    • Author(s)
      Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
    • Journal Title

      Mol Pharmacol

      Volume: 91 Pages: 159-166

    • DOI

      10.1124/mol.116.105569

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
  • [Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)2017

    • Author(s)
      Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
    • Journal Title

      J Biol Chem.

      Volume: 292 Pages: 4556-4570

    • DOI

      10.1074/jbc.m116.768853

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
  • [Journal Article] Improved anticancer effects of albumin-bound paclitaxel nanoparticle via augmentation of EPR effect and albumin-protein interactions using S-nitrosated human serum albumin dimer2017

    • Author(s)
      Kinoshita R, Ishima Y, Chuang VTG, Nakamura H, Fang J, Watanabe H, Shimizu T, Okuhira K, Ishida T, Maeda H, Otagiri M, Maruyama T.
    • Journal Title

      Biomaterials

      Volume: 140 Pages: 162-169

    • DOI

      10.1016/j.biomaterials.2017.06.021

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-15H04758, KAKENHI-PROJECT-15K08076
  • [Journal Article] Development of a peptide-based inducer of nuclear receptors degradation2016

    • Author(s)
      Demizu Y, Ohoka N, Nagakubo T, Yamashita H, Misawa T, Okuhira K, Naito M, Kurihara M.
    • Journal Title

      Bioorg Med Chem Lett

      Volume: 26 Pages: 2655-2658

    • DOI

      10.1016/j.bmcl.2016.04.013

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
  • [Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.2016

    • Author(s)
      K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
    • Journal Title

      Methods Mol Biol

      Volume: 1366 Pages: 549-560

    • DOI

      10.1007/978-1-4939-3127-9_42

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
  • [Journal Article] Iowa Mutant Apolipoprotein A-I (ApoA-I Iowa) Fibrils Target Lysosomes2016

    • Author(s)
      Kameyama H., Nakajima H., Nishitsuji K., Mikawa S., Uchimura K., Kobayashi N., Okuhira K., Saito H., and Sakashita N.
    • Journal Title

      Sci Rep.

      Volume: 6 Pages: 30391-30391

    • DOI

      10.1038/srep30391

    • NAID

      120006534966

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-15K19488, KAKENHI-PROJECT-15K08629, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-16K08712, KAKENHI-PROJECT-15K08265
  • [Journal Article] Formation of stable nanodiscs by bihelical apolipoprotein A-I mimetic peptide.2016

    • Author(s)
      Kariyazono, H., Nadai, R., Miyajima, R., Takechi-Haraya, Y., Baba, T., Shigenaga, A., Okuhira, K., Otaka, A., and Saito, H.
    • Journal Title

      J Pept Sci.

      Volume: 22 Pages: 116-122

    • DOI

      10.1002/psc.2847

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25293006, KAKENHI-PROJECT-16K08236
  • [Journal Article] Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.2015

    • Author(s)
      T. Shoda,* M. Kato, T. Fujisato, K. Okuhira, Y. Demizu, H. Inoue, M. Naito, M. Kurihara*
    • Journal Title

      Bioorg Med Chem.

      Volume: 23 Pages: 3091-3096

    • DOI

      10.1016/j.bmc.2015.05.002

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-25430164
  • [Journal Article] Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.2015

    • Author(s)
      Y. Demizu*, T. Misawa, T. Nagakubo, Y. Kanda, K. Okuhira, Y. Sekino, M. Naito, M. Kurihara*
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 23 Pages: 4132-4138

    • DOI

      10.1016/j.bmc.2015.06.067

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26670041
  • [Journal Article] Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator2014

    • Author(s)
      Shoda, T., Okuhira, K., Kato, M., Demizu, Y., Inoue, H., Naito, M., and Kurihara, M.
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 87-89

    • DOI

      10.1016/j.bmcl.2013.11.078

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
  • [Journal Article] Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin-proteasome pathway.2014

    • Author(s)
      1.Ohoka, N., Nagai, K., Hattori, T., Okuhira, K., Shibata, N., Cho, N. and Naito, M
    • Journal Title

      Cell Death and Disease

      Volume: 5

    • DOI

      10.1038/cddis.2014.471

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26860049
  • [Journal Article] Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription2014

    • Author(s)
      2.Nagakubo, T., Demizu, Y., Kanda, Y., Misawa, T., Shoda, T., Okuhira, K., Sekino., Y., Naito, M. and Kurihara, M
    • Journal Title

      Bioconjugate Chem.

      Volume: 25 Pages: 1921-1924

    • DOI

      10.1021/bc500480e

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860085
  • [Journal Article] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013

    • Author(s)
      Okuhira, K., Demizu, Y., Hattori, T., Ohoka, N., Shibata, N., Nishimaki-Mogami, T., Okuda, H., Kurihara, M., Natiro, M.
    • Journal Title

      Cancer Sci.

      Volume: 104 Pages: 1492-1498

    • DOI

      10.1111/cas.12272

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23790117, KAKENHI-PUBLICLY-25112521, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-25460084
  • [Journal Article] Hepatocyte Nuclear Factor 4alpha Increases Liver-specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to ApoA-I in Response to Cholesterol Depletion.2012

    • Author(s)
      Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito M, Nishimaki-Mogami T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 1005-1014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Journal Article] HDL産生におけるABCトランスポーターA1の活性制御機構2012

    • Author(s)
      奥平 桂一郎
    • Journal Title

      生化学

      Volume: 84巻 4号 Pages: 285-290

    • NAID

      10030741431

    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] HNF4α increases liver-specific human ATP-binding cassette transporter A1 expression and cholesterol efflux to apolipoprotein A-I in response to cholesterol depletion.2012

    • Author(s)
      Ohoka N, Okuhira K, Cui H, Wu W, Sato R, Naito N, and Nishimaki-Mogami T
    • Journal Title

      Arterioscler Thromb Vase Biol

      Volume: 32 Pages: 1005-1014

    • DOI

      10.1161/atvbaha.111.238360

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19108002, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23790117
  • [Journal Article] HDL 産生におけるABC トランスポーターA1 の活性制御機構2012

    • Author(s)
      奥平桂一郎
    • Journal Title

      生化学

      Volume: 84巻4号 Pages: 285-290

    • NAID

      10030741431

    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] Hepatocyte Nuclear Factor 4alpha Increases Liver-specific Human ATP- Binding Cassette Transporter A1 Expression and Cholesterol Efflux to ApoA-I in Response to Cholesterol Depletion2012

    • Author(s)
      Ohoka N, Okuhira K, Cui H, Wu W, Sato R,Naito M, Nishimaki-Mogami T
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Pages: 1005-1014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Journal Article] Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist.2012

    • Author(s)
      Y. Itoh, M. Ishikawa, R.Kitaguchi, K.Okuhira, M.Naito, Y.Hashimoto
    • Journal Title

      Bioorg Med Chem Lett.

      Volume: 22 Pages: 4453-4457

    • DOI

      10.1016/j.bmcl.2012.04.134

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048, KAKENHI-PROJECT-23790125
  • [Journal Article] Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.2012

    • Author(s)
      Y. Demizu, K. Okuhira, H. Motoi, A. Ohno, T. Shoda, K. Fukuhara, H. Okuda, M. Naito, M. Kurihara
    • Journal Title

      Bioorg.Med.Chem.Lett.

      Volume: 22 Pages: 1793-1796

    • DOI

      10.1016/j.bmcl.2011.11.086

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20390038, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-22790126, KAKENHI-PROJECT-23659048
  • [Journal Article] Specific degradation of CRABP-II via cIAP1-mediatd ubiquitylatlon induced by hybrid molecules that crosslink cIAP1 and the target protein2012

    • Author(s)
      K. Okuhira, N. Ohoka, K. Sai, T. Nishimaki-Mogami, Y. Itoh, M. Ishikawa, Y. Hashimoto, M. Naito
    • Journal Title

      FEBS Lett

      Volume: 585 Pages: 1147-1152

    • DOI

      10.1016/j.febslet.2011.03.019

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21651092, KAKENHI-PROJECT-22249006, KAKENHI-PROJECT-22790102, KAKENHI-PROJECT-23659048
  • [Journal Article] Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR2011

    • Author(s)
      Cui H, Okuhira K, Ohoka N, Naito M, Kagechika H, Hirose A, Nishimaki-Mogami T
    • Journal Title

      Biochemical Pharmacology

      Volume: 81 Pages: 819-24

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.2011

    • Author(s)
      Cui H, Okuhira K, Ohoka N, Naito M, Kagechika H, Hirose A, Nishimaki-Mogami T
    • Journal Title

      Biochem Pharmacol

      Volume: 81(6) Pages: 819-24

    • DOI

      10.1016/j.bcp.2010.12.023

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] (*corresponding author) Binding of PDZ-RhoGEF to ATP-Binding Cassette Transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.2010

    • Author(s)
      Okuhira K*, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T.
    • Journal Title

      J Biol Chem (in press)

    • Data Source
      KAKENHI-PROJECT-20790091
  • [Journal Article] Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation2010

    • Author(s)
      Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 285 Pages: 16369-77

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] Modulation of RIP1 ubiquitylation and distribution by MeBS to sensitize cancer cells to tumor necrosis factor α-induced apoptosis.2010

    • Author(s)
      Kim S, Ohoka N, Okuhira K, Sai K, Nishimaki-Mogami T, Naito M
    • Journal Title

      Cancer Sci

      Volume: 101(11) Pages: 2425-9

    • DOI

      10.1111/j.1349-7006.2010.01697.x

    • NAID

      10027833689

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] Binding of PDZ-RhoGEF to ATP-binding cassette transporter A1 (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation.2010

    • Author(s)
      Okuhira K, Fitzgerald ML, Tamehiro N, Ohoka N, Suzuki K, Sawada J, Naito M, Nishimaki-Mogami T
    • Journal Title

      J Biol Chem

      Volume: 285(21) Pages: 16369-77

    • DOI

      10.1074/jbc.m109.061424

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Journal Article] The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines.2008

    • Author(s)
      Nishimaki-Mogami T, Tamehiro N, Sato Y, Okuhira K, Sai K, Kagechika H, Shudo K, Abe-Dohmae S, Yokoyama S, Ohno Y, Inoue K, Sawada J.
    • Journal Title

      Biochem Pharmacol 76(8)

      Pages: 1006-13

    • Data Source
      KAKENHI-PROJECT-20790091
  • [Journal Article] SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter.2008

    • Author(s)
      Tamehiro N, Zhou S, Okuhira K, Benita Y, Brown CE, Zhuang DZ, Latz E, Hornemann T, von Eckardstein A, Xavier RJ, Freeman MW, Fitzgerald ML.
    • Journal Title

      Biochemistry 47(23)

      Pages: 6138-47

    • Data Source
      KAKENHI-PROJECT-20790091
  • [Journal Article] Binding of PDZ-RhoGEF to ATP-binding cassette transporter Al (ABCA1) induces cholesterol efflux through RhoA activation and prevention of transporter degradation

    • Author(s)
      Okuhira, et al.
    • Journal Title

      The Journal of Biological Chemistry (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Patent] アポトーシス阻害タンパク質リガンド-エストロゲン受容体リガンドハイブリッド化合物並びにそれを利用したエストロゲン受容体分解誘導剤及び乳癌、子宮頸癌又は卵巣癌の予防及び治療剤2011

    • Inventor(s)
      内藤幹彦、奥平桂一郎、出水庸介、栗原正明
    • Industrial Property Rights Holder
      財団法人ヒューマンサイエンス財団
    • Industrial Property Number
      2011-195081
    • Filing Date
      2011-09-07
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] 免疫抑制剤フィンゴリモドがマクロファージへの脂質蓄積に与える影響2021

    • Author(s)
      立花 洸季、小川 真依、石田 竜弘、異島 優、奥平 桂一郎
    • Organizer
      日本薬学会 第141年会
    • Data Source
      KAKENHI-PROJECT-20H04124
  • [Presentation] 3T3-L1前駆脂肪細胞の分化誘導に対するスルフォラファン及びアリルイソチオシアネートの影響2021

    • Author(s)
      佐久間 覚、奥平 桂一郎
    • Organizer
      日本薬学会 第141年会
    • Data Source
      KAKENHI-PROJECT-20H04124
  • [Presentation] 脂質トランスポーターABCA7の発現制御機構解明に向けた研究2020

    • Author(s)
      奥平 桂一郎
    • Organizer
      第15回トランスポーター研究会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H04124
  • [Presentation] 動脈硬化性疾患を標的としたHDL創薬への挑戦2020

    • Author(s)
      奥平 桂一郎
    • Organizer
      徳島大学大学院医歯薬学研究部・BRIGHT合同公開シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-20H04124
  • [Presentation] 天然物による膜トランスポーターABCA7の発現増強機構の解析2019

    • Author(s)
      楠本嵩志,堂前純子,田中直伸,柏田良樹,辻大輔,伊藤孝司,石田竜弘,奥平桂一郎
    • Organizer
      第92回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 難治性膵臓がんへの高い移行性を有するアルブミンナノ粒子の開発2019

    • Author(s)
      平川尚樹,異島優,木下遼,清水太郎,丸山徹,奥平桂一郎,石田竜弘
    • Organizer
      日本薬剤学会第34年会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] プロテインノックダウン法を用いたチミジル酸合成酵素分解誘導剤開発2019

    • Author(s)
      有井紗由季,上田将弘,重永章,大髙章,石田竜弘,奥平桂一郎
    • Organizer
      第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 多発性硬化症治療薬FTY720のアポリポタンパク質発現に対する影響2019

    • Author(s)
      小川真依,立花洸季,石田竜弘,奥平桂一郎
    • Organizer
      第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] アンチセンスのキャリア非依存性取り込み機構に寄与する膜タンパク質の検討2019

    • Author(s)
      内海彩花,佐々木澄美、楠本嵩志,吉田徳幸,石田竜弘,井上貴雄,奥平桂一郎
    • Organizer
      第58回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] Sphingosine-1-phosphate (S1P) affects the secretion of high density lipoprotein (HDL)-constituent protein.2018

    • Author(s)
      Tachibana, K., Tanaka, T., Kogure, K., Ishida, T., Okuhira, K.
    • Organizer
      12th International Symposium on Nanomedicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 膜タンパク質ABCA7を増加させる新規天然物2018

    • Author(s)
      楠本嵩志、堂前純子、田中直伸、柏田良樹、辻大輔、伊藤孝司、石田竜弘、奥平桂一郎
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 共有結合型アルブミンナノ粒子をキャリアとしたナノDDS抗がん剤の開発及び有用性評価2018

    • Author(s)
      平川尚樹、木下遼、異島優、清水太郎、丸山徹、奥平桂一郎、石田竜弘
    • Organizer
      第34回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 共有結合型アルブミンナノ粒子を用いたセラノスティックナノDDS抗がん剤の開発2018

    • Author(s)
      平川尚樹、異島優、木下遼、清水太郎、丸山徹、奥平桂一郎、石田竜弘
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 炎症モデルマウスにおけるapoA-I結合タンパク質AIBPの抗炎症作用の検討2018

    • Author(s)
      橘茉里奈、末永翔平、楠本嵩志、杉原涼、髙田春風、西辻和親、辻田麻紀、石田竜弘、奥平桂一郎
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] HDL構成タンパク質分泌に対するスフィンゴシン-1-リン酸及びフィンゴリモドの影響2018

    • Author(s)
      立花洸季、田中保、小暮健太朗、石田竜弘、奥平桂一郎
    • Organizer
      第91回日本生化学会大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] HDL構成タンパク質分泌に対するスフィンゴシン-1-リン酸及びフィンゴリモドの影響2018

    • Author(s)
      立花洸季、田中保、小暮健太朗、石田竜弘、奥平桂一郎
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 人工HDLの化学的性状と体内動態への影響に関する検討2018

    • Author(s)
      金山忠史、奥平桂一郎、大川内健人、清水太郎、重永章、大高章、石田竜弘
    • Organizer
      第57回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] apoA-I結合タンパク質AIBPの抗炎症活性発現メカニズムの検討2018

    • Author(s)
      末永翔平、金山忠史、橘茉里奈、楠本嵩志、杉原涼、西辻和親、辻田麻紀、石田竜弘、奥平桂一郎
    • Organizer
      日本薬学会第139年会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] ヒトアポA-I結合タンパク質AIBPの新規機能解明2018

    • Author(s)
      橘 茉里奈, 杉原 涼, 藤見 紀明, 西辻 和親, 坂下 直実, 辻田 麻紀, 石田 竜弘, 奥平 桂一郎
    • Organizer
      日本薬学会第138年会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] Xanthohumol を用いたDNAトランスフェクション効率の改善2018

    • Author(s)
      宮下直樹、奥平桂一郎、石田竜弘
    • Organizer
      第34回日本DDS学会学術集会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 抗動脈硬化性タンパク質を利用した創薬への挑戦2018

    • Author(s)
      奥平桂一郎
    • Organizer
      日本薬学会第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 動脈硬化治療を指向した光制御型HDL構成ペプチドの開発2018

    • Author(s)
      宮下直樹、奥平桂一郎、川原遥華、津田雄介、森本恭平、辻耕平、重永章、大高章、石田竜弘
    • Organizer
      日本薬剤学会第33年会
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] ヒトアポA-I結合タンパク質AIBPのLPS誘導性マクロファージ炎症反応抑制効果2017

    • Author(s)
      藤見紀明,杉原涼,西辻和親,坂下直実,辻大輔,伊藤孝司,辻田麻紀,奥平桂一郎
    • Organizer
      日本薬学会第137年会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2017-03-24
    • Data Source
      KAKENHI-PROJECT-16K08236
  • [Presentation] 網羅的人工ユビキチン修飾システムの構築2016

    • Author(s)
      大岡 伸通, 伊東 昌宏, 奥平 桂一郎, 永井 克典, 柴田 識人, 服部 隆行, 長 展生, 内藤 幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016

    • Author(s)
      服部 隆行, 正田 卓司, 奥平 桂一郎, 柴田 識人, 大岡 伸通, 伊藤 進, 栗原 正明, 内藤 幹彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-03-26
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] タモキシフェン骨格を有する新規エストロゲン受容体分解誘導剤の開発2014

    • Author(s)
      加藤雅士,正田卓司,奥平桂一郎,井上英史,内藤幹彦, 栗原正明
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] Bestatin/tamoxifen hybrid molecule induces proteasomal degradation of estrogen receptor a and necrotic cell death in breast cancer cells2014

    • Author(s)
      Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M
    • Organizer
      Keystone Symposia on Molecular and Cellular Biology, The Ubiquitin System: From Basic Science to Drug Discovery
    • Place of Presentation
      米国ビッグスカイ
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] エストロゲン受容体転写阻害ペプチドの創製2014

    • Author(s)
      長久保貴哉,出水庸介,佐藤由紀子,諫田泰成,奥平桂一郎,関野祐子,内藤幹彦,栗原正明
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] エストロゲン受容体分解誘導剤による乳癌の細胞死誘導分子機構2014

    • Author(s)
      奥平桂一郎,出水庸介,服部隆行,大岡伸通,柴田識人,最上(西巻)知子,栗原正明,奥田晴宏,内藤幹彦
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] エンドキシフェン骨格を持つ新規エストロゲン受容体分解誘導剤の開発2013

    • Author(s)
      加藤雅士,正田卓司,奥平桂一郎,井上英史,内藤幹彦,栗原正明
    • Organizer
      第31回メディシナルケミストリーシンポジウム
    • Place of Presentation
      広島市
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells2013

    • Author(s)
      Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami, T, Okuda H, Kurihara M, Naito M
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      米国ボストン
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] 細胞内に局在するタンパク質を標的としたプロテインノックダウン効果の検討2013

    • Author(s)
      奥平桂一郎,大岡伸通,最上(西巻)知子,伊藤幸裕,石川稔,橋本祐一,内藤幹彦
    • Organizer
      第17回日本がん分子標的治療学会学術集会
    • Place of Presentation
      京都市
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubes have abilities to induce IL-1beta secretion through NLRP3-dependent mechanism depending on their lengths2013

    • Author(s)
      Nishimaki-Mogami T, Cui H, Wu W, Okuhira K, Naito M, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Miyazawa K, Hirose A
    • Organizer
      Eurotox2013
    • Place of Presentation
      Interlaken, Switzerland
    • Year and Date
      2013-09-03
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] SNIPER induces ubiquitylation and proteasomal degradation of estrogen receptor followed by rapid cell death in breast cancer cells2013

    • Author(s)
      Okuhira K, Demizu Y, Ohoka N, Shibata N, Hattori T, Nishimaki-Mogami T, Kurihara M, Okuda H, Naito M
    • Organizer
      The 35th Naito Conference; The Ubiquitin-Proteasome System
    • Place of Presentation
      札幌市
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] Mechanism underlying multiwall carbon nanotube-induced IL-1beta secretion2012

    • Author(s)
      Nishimaki-Mogami T, Cui H, Okuhira K, Naito M, Suzuki K, Nishimura T, Hirose A
    • Organizer
      EUROTOX 2012
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2012-06-19
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] Hepatocyte Nuclear Factor 4alpha(HNF4alpha) Regulates Liver-specific Human ATP-binding Cassette Protein A1 (ABCA1) Gene Expression in Response to Cholesterol Depletion2012

    • Author(s)
      Ohoka N, Okuhira K, Cui H, Wu W, Naito M, Nishimaki-Mogami T
    • Organizer
      ASBMB Symposium "Frontiers in Lipid Biology"
    • Place of Presentation
      Banff, Canada
    • Year and Date
      2012-09-05
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] An Anion-Exchange Chromatography Isolated Subfraction of Mouse Apolipoprotein A-I Is Unable to Activate Cellular Cholesterol Release from Mouse Peritoneal Macrophage Foam Cells2012

    • Author(s)
      Okumura-Noji K, Cavigiolio G, Huang R, Davidson WS, Akita N, Okuhira K, Yokoyama S, Tsujita M.
    • Organizer
      ATVB, 2012
    • Place of Presentation
      Chicago, IL, USA
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] Anion-Exchange Chromatography Isolated Subfraction of Mouse Apolipoprotein A-I Is Unable to Activate Cellular Cholesterol Release from Mouse Peritoneal Macrophage Foam Cells.2012

    • Author(s)
      Okumura-Noji K, Okuhira K
    • Organizer
      Arteriosclerosis, Thrombosis, and Vascular Biology
    • Place of Presentation
      シカゴ、米国
    • Year and Date
      2012-04-18
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] 多層カーボンナノチューブはNLRP3活性化を介してIL-1β産生を促進する2011

    • Author(s)
      最上(西巻)知子, 崔紅艶, 岩崎香里, 奥平桂一郎, 内藤幹彦, 鈴木和博, 広瀬明彦
    • Organizer
      第38回日本トキシコロジー学会学術年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-11
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] 多層カーボンナノチューブによるIL-1β産生促進とその機構2011

    • Author(s)
      最上(西巻) 知子, 崔 紅艶, 岩崎 香里, 奥平 桂一郎, 内藤 幹彦, 鈴木 和博, 広瀬 明彦
    • Organizer
      フォーラム2011 衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] 多層カーボンナノチューブによるIL-1β産生促進とその機構2011

    • Author(s)
      最上(西巻)知子, 崔紅艶, 岩崎香里, 奥平桂一郎, 内藤幹彦, 鈴木和博, 広瀬明彦
    • Organizer
      フォーラム2011衛生薬学・環境トキシコロジー
    • Place of Presentation
      金沢
    • Year and Date
      2011-10-28
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] PDZ-RhoGEF binds ABCA1 and increases transporter expression and cholesterol effiux via RhoA activation2010

    • Author(s)
      奥平桂一郎
    • Organizer
      The 27th Naito Conference
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-30
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] ABCA1 相互作用タンパク質とRho を介した脂質搬出反応の制御2010

    • Author(s)
      最上知子、奥平桂一郎
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2010-11-30
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] PDZ-RhoGEF binds ABCA1 and increases transporter expression and cholesterol efflux via RhoA activation.2010

    • Author(s)
      奥平桂一郎
    • Organizer
      第27回内藤カンファレンス
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-30
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] Binding of PDZ-RhoGEF to ABCA1 induces cholesterol efflux through RhoA activation and prevention of transporter degradation2010

    • Author(s)
      奥平桂一郎
    • Organizer
      第42回日本動脈硬化学会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] グアニンヌクレオチド交換因子によるABCA1活性制御機構2010

    • Author(s)
      奥平桂一郎
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Presentation] Binding of PDZ-RhoGEF to ABCA1 induces cholesterol efflux through RhoA activation and prevention of transporter degradation.2010

    • Author(s)
      奥平桂一郎
    • Organizer
      第42回日本動脈硬化学会
    • Place of Presentation
      岐阜
    • Year and Date
      2010-07-16
    • Data Source
      KAKENHI-PROJECT-22790102
  • [Presentation] 最上(西巻)知子グアニンヌクレオチド交換因子によるABCA1活性制御機構2010

    • Author(s)
      奥平桂一郎, 大岡伸通, 崔紅艶, 岩崎香里, 内藤幹彦
    • Organizer
      日本薬学会130年会
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Presentation] ABCA1相互作用タンパク質とPHoAによるHDL形成制御機構2009

    • Author(s)
      奥平桂一郎
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-26
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Presentation] 最上(西巻)知子ABCA1相互作用タンパク質とRhoAによるHDL形成制御機構2009

    • Author(s)
      奥平桂一郎, 大岡伸通, 崔紅艶, 澤田純一
    • Organizer
      日本薬学会129年会
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Presentation] 最上(西巻)知子ABCA1相互作用タンパク質とRhoAによるHDL形成制御機構2009

    • Author(s)
      奥平桂一郎, 大岡伸通, 崔紅艶, 内藤幹彦
    • Organizer
      第51回日本脂質生化学会
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Presentation] ABCA1相互作用タンパク質とRhoAによるHDL形成制御機構2009

    • Author(s)
      奥平桂一郎
    • Organizer
      第51回日本脂質生化学会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-31
    • Data Source
      KAKENHI-PROJECT-20790091
  • [Presentation] GEF11によるABCA1安定化機構2008

    • Author(s)
      奥平 桂一郎
    • Organizer
      日本薬学会128年会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-18790078
  • [Presentation] The guanine exchange factor 11 PDZ protein binds ABCA1 positively regulating transporter expression and cholesterol efflux via Rho activation2007

    • Author(s)
      Okuhira K
    • Organizer
      American Heart Association, scientific sessions 2007
    • Place of Presentation
      Orland, FL
    • Data Source
      KAKENHI-PROJECT-18790078
  • [Presentation] エストロゲン受容体転写活性化阻害ペプチドの創製

    • Author(s)
      出水 庸介, 長久保 貴哉, 三澤 隆史, 諫田 泰成, 奥平 桂一郎, 関野 祐子, 内藤 幹彦, 栗原 正明
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] ユビキチン・プロテアソームシステムを利用した TACC3 分解誘導剤の開発と抗がん活性評価

    • Author(s)
      大岡 伸通, 永井 克典, 服部 隆行, 奥平 桂一郎, 柴田 識人, 長 展生, 内藤 幹彦
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] タモキシフェン骨格を有する分解誘導剤のアルキル鎖長および末端構造の最適化

    • Author(s)
      正田 卓司, 加藤 雅士, 藤里 卓磨, 原田 麟太郎, 奥平 桂一郎, 井上 英史, 内藤 幹彦, 栗原 正明
    • Organizer
      日本薬学会第135年会
    • Place of Presentation
      神戸学院大学(兵庫県・神戸市)
    • Year and Date
      2015-03-25 – 2015-03-28
    • Data Source
      KAKENHI-PROJECT-25430164
  • [Presentation] High-temperature calcined fullerene nanowhiskers and multi-wall carbon nanotubes have abilities to induce IL-1beta secretion through NLRP3-dependent mechanism, depending on their lengths

    • Author(s)
      Nishimaki-Mogami T, Cui H, Wu W, Okuhira K, Naito M, Nishimura T, Sakamoto Y, Ogata A, Maeno T, Inomata A, Nakae D, Miyazawa K, Hirose A
    • Organizer
      Eurotox2013
    • Place of Presentation
      Interlaken, Switzerland
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] Hepatocyte Nuclear Factor 4alpha(HNF4alpha) Regulates Liver-specific Human ATP-binding Cassette Protein A1 (ABCA1) Gene Expression in Response to Cholesterol Depletion

    • Author(s)
      Ohoka N, Okuhira K, Cui H, Wu W, Naito M, Nishimaki-Mogami T.
    • Organizer
      ASBMB Symposium "Frontiers in Lipid Biology"
    • Place of Presentation
      Banff
    • Data Source
      KAKENHI-PROJECT-23590164
  • [Presentation] Mechanism underlying multiwall carbon nanotube-induced IL-1beta secretion.

    • Author(s)
      Nishimaki-Mogami T, Cui H, Okuhira K, Naito M, Suzuki K, Nishimura T, Hirose A.
    • Organizer
      EUROTOX 2012
    • Place of Presentation
      Stockholm
    • Data Source
      KAKENHI-PROJECT-23590164
  • 1.  NISHIMAKI-MOGAMI Tomoko (90174333)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 11 results
  • 2.  DEMIZU Yosuke (90389180)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 16 results
  • 3.  清水 太郎 (30749388)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  田中 将史 (40411904)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  石田 竜弘 (50325271)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 5 results
  • 6.  長谷井 友尋 (10388027)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  鳥羽 陽 (50313680)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  辻田 麻紀 (10253262)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  横山 信治 (10142192)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  ISHIMA Yu
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 11.  WATANABE Hiroshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 12.  MARUYAMA Toru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 13.  ISHIKAWA Minoru
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 14.  SYODA Takuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 5 results
  • 15.  UCHIMURA Kenji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 16.  SHIGENAGA Akira
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 17.  KANDA Yasunari
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 18.  OKUDA Haruhiro
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 19.  OHNO Akiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  大岡 伸通
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 8 results
  • 21.  内藤 幹彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 11 results
  • 22.  伊藤 拓水
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  服部 隆行
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 24.  大高 章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 25.  斎藤 博幸
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 4 results
  • 26.  西辻 和親
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 27.  栗原 正明
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 28.  小田切 優樹
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 29.  赤池 孝章
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 30.  伊東 進
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 31.  森岡 弘志
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 32.  柴田 識人
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 33.  原 孝彦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 34.  安藤 英紀
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 35.  赤路 健一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 36.  小林 典裕
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 37.  坂下 直実
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 38.  佐藤 隆一郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 39.  橋本 祐一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 40.  福原 潔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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