Iwai Kazuhiro 岩井一宏

… Alternative Names

Researcher Number	60252459
Other IDs	https://orcid.org/0000-0001-5620-5951
External Links
Affiliation (Current)	2022: 京都大学, 医学研究科, 教授
Affiliation (based on the past Project Information) *help	2015 – 2022: 京都大学, 医学研究科, 教授 2017: 京都大学, 大学院医学研究科細胞機能制御学講座, 教授 2017: 京都大学, 大学院医学研究科, 教授 2012 – 2015: 京都大学, 医学(系)研究科(研究院), 教授 2012: 大阪大学, 医学(系)研究科(研究院), 招聘教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / Functional biochemistry / Pathological medical chemistry / Complex systems / Medium-sized Section 48:Biomedical structure and function and related fields / Broad Section H Except Principal Investigator Biological Sciences / Pathological medical chemistry / Immunology … More
Keywords	Principal Investigator ユビキチン / ユビキチン修飾 / プロテアソーム / 選択的蛋白分解 / 生体分子 / NF-kappaB / 直鎖状ユビキチン鎖 / 鉄イオン代謝 / ストレス / IRP2 … More Except Principal Investigator ユビキチン / 細胞・組織 / 蛋白質 / Rap1 / 出芽酵母 / 酵素 / 鉄代謝 / 鉄-硫黄クラスター / シグナル伝達 / 細胞周期 / 転写制御 / 核外移行 / タンパク質分解 / オートファジー / 低分子量G蛋白 / GTPase活性化蛋白 / バキュロウイルス / 低分子G蛋白 / Ras / SPA-1 / cell adhesion / C3G / 32D / integrin / 細胞内鉄濃度 / 転写因子 / 代謝 / 鉄取り込み / バンド・シフト法 / 鉄センシング機構 / 核移行 / ストレス応答 / ユビキチン様蛋白質 / 脱ユビキチン化 / プロテアソーム / ユビキチンワールド / ストレス / カルパイン / プロテアーゼ / プロテオリシス / 細胞内情報伝達 / 細胞構造・機能 / 構造生物学 / パーキンソン病 / 遺伝性パーキンソン病 / 共通機構 / 新規原因遺伝子 / 劣性遺伝性パーキンソン病 / ミトコンドリア機能 / PINK1 / Parkin / DJ-1 / autophagy-lysosomal path& / ATP132 / ユビキチン化 / 常染色体劣性晩発性パーキンソン病 / 連鎖解析 / タンバク質 / 酵素の調節 / 細胞内タンパク質分解 / タンパク質 / 分子腫瘍学 / 炎症 / arthritis / inflammation / NF kappa B / LUBAC / 関節リウマチ / NF-kB / リンパ球 / 細胞増殖 / 染色体マッピング / G蛋白活性化蛋白 / がん遺伝子 / がん抑制遺伝子 / サイトカイン / リンパ球活性化 / 細胞分裂 / 細胞同期 / 核内蛋白 / ロイシンジッパー / lymphocutes / small G protein / GTPase activating protein / cell cycle / baculovirus / proliferation / chusmosomal mapping / 細胞骨格 / 抗原レセプター / 免疫応答 / GTPase活性化蛋白(GAP) / アナ-ジ- / クローン増巾 / Small GTPases / Rap 1 / Cytaskleton / Signal transduction / Antigen receptors / Immune response / GTPase activating protain(GAP) / B型肝炎ウイルス / 肝細胞癌 / トランス活性化 / B型肝炎ウィルス / ubiquitin / hepatitis B virus / NF-κB / transactivation / henatocarcinoma / ミトコンドリア / ノックアウト / 鉄-硫黄ラスター / DT40 / 鉄 / 鉄ー硫黄クラスター / トリBリンパ細胞 / mitochondria / iron metabolism / iron-sulfur cluster / knock-out / Saccharomyces cerevisiae / ウイルス / 癌 / protein / enzyme / virus / transcription / 細胞内分解 / リソソーム / 生理学 / 遺伝子 / 脳神経疾患 / 神経変性疾患 / 悪性リンパ腫 / マウスモデル / Ｂ細胞リンパ腫 / MyD88 / HOIP / NF-kappaB / ケミカルバイオロジー / 翻訳後修飾 / ステープルペプチド Less

Involvement of linear ubiquitination in regulation of cancer and immunityPrincipal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 48:Biomedical structure and function and related fields
- Research Institution
  Kyoto University
Integrated analyses of LUBAC-mediated linear ubiquitinationPrincipal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2022 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Review Section
  
  Broad Section H
- Research Institution
  Kyoto University
New frontier for ubiquitin biology driven by chemo-technologies
- Principal Investigator
  
  佐伯泰
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tokyo Metropolitan Institute of Medical Science
Functional regulation of ubiquitin chains using chemo-technologiesPrincipal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Kyoto University
ユビキチンネオバイオロジー：拡大するタンパク質制御システムPrincipal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Kyoto University
Extensive analyses of the LUBAC ubiquitin ligasePrincipal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
直鎖状ユビキチン鎖による生体制御機構の解析Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2017
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Clarifying the pathogenesis of ABC-DLBCL in a mouse model
- Principal Investigator
  
  Nishikori Momoko
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hematology
- Research Institution
  Kyoto University
Development of small molecules inhibiting linear ubiquitin-medaited NF-kappaB actviationPrincipal Investigator
- Principal Investigator
  
  Kazuhiro wai
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyoto University
Patho-physiological function of the ubiquitin ligase that generates linear ubiquitin chains (LUBAC)Principal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
Multidisciplinary research on autophagy: from molecular mechanisms to disease states
- Principal Investigator
  
  Mizushima Noboru
- Project Period (FY)
  2013 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
New aspect of the ubiquitin system : its enormous roles in protein regulationPrincipal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Generation and function of linear ubiquitin chainsPrincipal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Development of regulators of the LUBAC ubiquitin ligase that modulate NF-kappaB activationPrincipal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
New aspect of the ubiquitin system : its enormous roles in protein regulationArea Organizer
- Area Organizer
  
  岩井一宏
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
Analysis of pathophysiology of LUBAC mediated NF-kappaB activationPrincipal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Kyoto University
  Osaka University
Novel activation pathway of NF-kB via LUBAC in patient with rheumatoid arthritis
- Principal Investigator
  
  TOMITA Tetsuya
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Osaka University
PUBドメイン含有ユビキチンリガーゼの品質管理における役割
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Relationship between inflammation and novel NF-κB activation pathway which is regulated by ubiquitin system
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka University
Identification of a common pathway among gene products for familial Parkinson's disease and screening for a novel causative gene for
- Principal Investigator
  
  HATTORI Nobutaka
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Juntendo University
鉄イオンによる転写制御機構の分子基盤
- Principal Investigator
  
  岩井裕子
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Mechanism underlying selective substrate recognition by the ubiquitin systemPrincipal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2006 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
  Osaka City University
Proteolysis in the Regulation of Biological Processes
- Principal Investigator
  
  MIZUSHIMA Noboru
- Project Period (FY)
  2006 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
新規RING型ユビキチンリガーゼ複合体のタンパク質品質管理における役割
- Principal Investigator
  
  徳永文稔
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
鉄イオンによる転写制御の分子基盤
- Principal Investigator
  
  岩井裕子
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
Involvement of ubiquitin system on the hepatitis B virus X protein (HBx)-mediated transactivation activity
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
Roles of mitochondria in iron metabolism
- Principal Investigator
  
  IWAI Yuko
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyoto University
酸化修飾認識ユビキチンリガーゼ(HOIL-1)のタンパク質品質管理における役割
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
Effects of HOIL-1 ubiquitin ligase complex on the physiological function of hepatitis B virus X protein
- Principal Investigator
  
  TOKUNAGA Fuminori
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Osaka City University
酸化タンパクを識別するユビキチンリガーゼHOIL―1の機能解析Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Osaka City University
Physiology and pathology of the ubiquitin-mediated quality control systemPrincipal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  Osaka City University
pVHLリガーゼによる環境応答Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka City University
  Kyoto University
酸化変化を認識するユビキチンシステムの神経変性疾患の封入体形成への関与Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
がん抑制遺伝子産物pVHLユビキチンリガーゼ欠損による発がん機構Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
ユビキチンワールド:新しい生体反応制御システム
- Principal Investigator
  
  横沢英良
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hokkaido University
細胞内鉄濃度を制御する転写因子の鉄センシング機構と転写活性化機構
- Principal Investigator
  
  IWAI Yuko
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
Identification of a ubiquitin-ligase which recognizes oxidized proteins.Principal Investigator
- Principal Investigator
  
  IWAI Kazuhiro
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  KYOTO UNIVERSITY
酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kyoto University
低分子G蛋白シグナル系を介した造血系細胞分化制御機構
- Principal Investigator
  
  服部雅一
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyoto University
酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割Principal Investigator
- Principal Investigator
  
  岩井一宏
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Molecular mechanisms of lymphocyte proliferation during the development
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  KYOTO UNIVERSITY
Molecular mechanisms for cell cycle control in the immune system
- Principal Investigator
  
  MINATO Nagahiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  KYOTO UNIVERSITY

[Book] プログレッシブ生命科学　（第一版）2014
- Author(s)
  吉森保、岡正啓、米田悦啓、田中亀代次、西條將文、岩井一宏、菊池章、松本真司、岡村康司、山本浩靖、木原進士、松岡達、高木都、犬束歩、山中章弘、金井好克、磯谷綾子、伊川正人古川貴久、戸田達史、他
- Total Pages
  312
- Publisher
  南山堂
- Data Source
  KAKENHI-ORGANIZER-25111001
[Book] LUBAC, a novel ubiquitin ligase for linear ubiquitination, is crucial for inflammation and immune responses2012
- Author(s)
  Tokunaga, F., and Iwai, K
- Publisher
  Microbes Infect.
- Data Source
  KAKENHI-PROJECT-22249008
[Book] Generation and physiological roles of linear ubiquitin chains2012
- Author(s)
  Walczak, H., Iwai, K., and Dikic, I
- Publisher
  BMC Biol.
- Data Source
  KAKENHI-PROJECT-22249008
[Book] A novel NF-κB regulatory mechanism for inflammatory and immune responses by the LUBAC ubiquitin ligase complex Endocr J2012
- Author(s)
  Tokunaga, F. and Iwai K
- Publisher
  Linear ubiquitination
- Data Source
  KAKENHI-PROJECT-22249008
[Book] Diverse ubiquitin signaling in NF-B activation2012
- Author(s)
  Iwai, K
- Publisher
  Trends Cell Biol.
- Data Source
  KAKENHI-PROJECT-22249008
[Book] Methods Mol Biol.担当分Synthesis and analysis of linear ubiquitin chains. 229-238ページ2012
- Author(s)
  Iwai K.
- Total Pages
  661
- Publisher
  Humana Press
- Data Source
  KAKENHI-PROJECT-22249008
[Book] Linear polyubiquitin chains : a new modifier involved in NF-B activation and chronic inflammation including dermatitis2011
- Author(s)
  Iwai, K
- Publisher
  -Extra View- Cell Cycle
- Data Source
  KAKENHI-PROJECT-22249008
[Book] M.eds Landes Biosciences2010
- Author(s)
  Iwai, K.
- Publisher
  FUNCTIONS OF LINEAR UBIQUITIN CHAINS IN THE NF-κB PATHWAY Linear Polyubiquitin in NF-κB Signaling. Conjugation and Deconjugation of Ubiquitin Family Modifiers Groettrup
- Data Source
  KAKENHI-PLANNED-18076004
[Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers2010
- Author(s)
  Iwai K.
- Total Pages
  272
- Publisher
  Groettrup, M.eds Landes Biosciences
- Data Source
  KAKENHI-PLANNED-18076004
[Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers2010
- Author(s)
  Iwai K.
- Total Pages
  272
- Publisher
  Groettrup, M.eds Landes Biosciences
- Data Source
  KAKENHI-PROJECT-22249008
[Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers2010
- Author(s)
  Iwai, K.
- Publisher
  Landes Biosciences(In Press)
- Data Source
  KAKENHI-PLANNED-18076004
[Book] Conjugation and Deconjugation of Ubiquitin Family Modifiers2010
- Author(s)
  Iwai K.
- Total Pages
  272
- Publisher
  Groettrup, M.eds Landes Biosciences
- Data Source
  KAKENHI-ORGANIZER-18076008
[Book] Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12. Current Protocols in Cell Biology2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K., Weissman, A.M.
- Total Pages
  75
- Publisher
  Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino J, eds. John Wiley and Sons
- Data Source
  KAKENHI-PLANNED-18076004
[Book] J, eds.John Wiley and Sons2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K.Weissman, A.M.
- Publisher
  Studies of the ubiquitin proteasome system. Units 15.9 Current Protocols in Cell Biology Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino
- Data Source
  KAKENHI-PLANNED-18076004
[Book] Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12. Current Protocols in Cell Biology2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K.and Weissman, A.M.
- Total Pages
  75
- Publisher
  Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, eds. John Wiley and Sons;
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Book] Current Protocols in Cell(Biology Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino J, eds. John Wiley and Sons)2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K., Weissman, A.M.
- Publisher
  Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12.
- Data Source
  KAKENHI-ORGANIZER-18076008
[Book] Studies of the ubiquitin proteasome system. Units 15.9 Sections I-12. Current Protocols in Cell Biology2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K., Weissman, A.M.
- Total Pages
  75
- Publisher
  Bonifacino J. Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, Bonafacino J, (eds. John Wiley and Sons;)
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Structural Dynamic Heterogeneity of Polyubiquitin Subunits Affects Phosphorylation Susceptibility2021
- Author(s)
  Morimoto Daichi、Walinda Erik、Takashima Shingo、Nishizawa Mayu、Iwai Kazuhiro、Shirakawa Masahiro、Sugase Kenji
- Journal Title
  
  Biochemistry
  
  Volume: 60 Pages: 573-583
- DOI
  10.1021/acs.biochem.0c00619
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K15757, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19J13259, KAKENHI-PROJECT-18K19297, KAKENHI-PROJECT-18K14665
[Journal Article] LUBAC-mediated linear ubiquitination: a crucial regulator of immune signaling2021
- Author(s)
  IWAI Kazuhiro
- Journal Title
  
  Proc. Jpn. Acad., Ser. B
  
  Volume: 97 Issue: 3 Pages: 120-133
- DOI
  10.2183/pjab.97.007
- NAID
  130007996827
- ISSN
  0386-2208, 1349-2896
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174
[Journal Article] LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells.2020
- Author(s)
  Jo Tomoyasu、Nishikori Momoko、Kogure Yasunori、Arima Hiroshi、Sasaki Katsuhiro、Sasaki Yoshiteru、Nakagawa Tomoko、Iwai Fumie、Momose Shuji、Shiraishi Aki、Kiyonari Hiroshi、Kagaya Noritaka、Onuki Tetsuo、Shin-ya Kazuo、Yoshida Minoru、Kataoka Keisuke、Ogawa Seishi、Iwai Kazuhiro、Takaori-Kondo Akifumi
- Journal Title
  
  Blood
  
  Volume: 136 Pages: 684-697
- DOI
  10.1182/blood.2019002654
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-18H05499, KAKENHI-PLANNED-18H05503, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H05640, KAKENHI-PROJECT-19H05656, KAKENHI-PROJECT-17K08880, KAKENHI-PROJECT-18K08324
[Journal Article] Linear ubiquitin assembly complex regulates lung epithelial?driven responses during influenza infection2020
- Author(s)
  Brazee Patricia L.、Morales-Nebreda Luisa、Magnani Natalia D.、Garcia Joe G.N.、Misharin Alexander V.、Ridge Karen M.、Budinger G.R. Scott、Iwai Kazuhiro、Dada Laura A.、Sznajder Jacob I.
- Journal Title
  
  Journal of Clinical Investigation
  
  Volume: 130 Pages: 1301-1314
- DOI
  10.1172/jci128368
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174
[Journal Article] LUBAC, the E3 ligase complex generating linear polyubiquitin chains2020
- Author(s)
  佐々木克博、岩井一宏
- Journal Title
  
  生化学
  
  Volume: 92 Issue: 1 Pages: 20-27
- DOI
  10.14952/SEIKAGAKU.2020.920020
- ISSN
  0037-1017
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K15118, KAKENHI-ORGANIZER-18H05497
[Journal Article] Discovery of linear ubiquitination, a crucial regulator for immune signaling and cell death2020
- Author(s)
  Iwai Kazuhiro
- Journal Title
  
  The FEBS Journal
  
  Volume: 288 Pages: 1060-1069
- DOI
  10.1111/febs.15471
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174
[Journal Article] The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC.2020
- Author(s)
  Fuseya Yasuhiro、Fujita Hiroaki、Kim Minsoo、Ohtake Fumiaki、Nishide Akira、Sasaki Katsuhiro、Saeki Yasushi、Tanaka Keiji、Takahashi Ryosuke、Iwai Kazuhiro
- Journal Title
  
  Nat Cell Biol.
  
  Volume: － Pages: 663-673
- DOI
  10.1038/s41556-020-0517-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PROJECT-20K16144, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-19H00997, KAKENHI-PLANNED-18H05498
[Journal Article] Modulation of autoimmune pathogenesis by T cell-triggered inflammatory cell death2019
- Author(s)
  Sasaki, K., Himeno, A., Nakagawa, T., Sasaki, Y., Kiyonari, H. and Iwai, K.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Pages: 3878-3878
- DOI
  10.1038/s41467-019-11858-7
- NAID
  120006716601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08880, KAKENHI-PROJECT-18K15118, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174
[Journal Article] LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores2019
- Author(s)
  Wu Min、Chang Yan、Hu Huaibin、Mu Rui、Zhang Yucheng、Qin Xuanhe、Duan Xiaotao、Li Weihua、Tu Haiqing、Zhang Weina、Wang Guang、Han Qiuying、Li Ailing、Zhou Tao、Iwai Kazuhiro、Zhang Xuemin、Li Huiyan
- Journal Title
  
  Nature Communications
  
  Volume: 10 Pages: 273-273
- DOI
  10.1038/s41467-018-08043-7
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174
[Journal Article] Crucial Role of Linear Ubiquitin Chain Assembly Complex Mediated Inhibition of Programmed Cell Death in TLR4-Mediated B Cell Responses and B1b Cell Development2018
- Author(s)
  Sasaki Yoshiteru、Iwai Kazuhiro
- Journal Title
  
  The Journal of Immunology
  
  Volume: 印刷中 Pages: 3438-3449
- DOI
  10.4049/jimmunol.1701526
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08880, KAKENHI-PUBLICLY-17H05502, KAKENHI-PROJECT-17H06174
[Journal Article] SHARPIN-mediated regulation of protein arginine methyltransferase 5 controls melanoma growth.2018
- Author(s)
  Tamiya, H., Kim, H., Klymenko, O., Kim, H., Feng, Y., Zhang, T., Han, J.Y., Murao, A., Snipas, S.J., Jilaveanu, L., Brown, K., Kluger, H., Zhang, H., Iwai, K., and Ronai, Z.A.
- Journal Title
  
  J. Clin. Invest.
  
  Volume: 128 Pages: 517-530
- DOI
  10.1172/jci95410
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-17H06078, KAKENHI-PROJECT-17H06174
[Journal Article] Pathological endogenous α-synuclein accumulation in oligodendrocyte precursor cells potentially induces inclusions in multiple system atrophy.2018
- Author(s)
  Kaji Seiji、Maki Takakuni、Kinoshita Hisanori、Uemura Norihito、Ayaki Takashi、Kawamoto Yasuhiro、Furuta Takahiro、Urushitani Makoto、Hasegawa Masato、Kinoshita Yusuke、Ono Yuichi、Mao Xiaobo、Quach Tran H.、Iwai Kazuhiro、Dawson Valina L.、Dawson Ted M.、Takahashi Ryosuke
- Journal Title
  
  Stem Cell Reports
  
  Volume: 10 Pages: 30530-1
- DOI
  10.1016/j.stemcr.2017.12.001
- NAID
  120006377705
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26290023, KAKENHI-PUBLICLY-17H05698, KAKENHI-PLANNED-26117005, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H02356, KAKENHI-PROJECT-15H04266, KAKENHI-PROJECT-16K18383
[Journal Article] HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection2018
- Author(s)
  MacDuff Donna A.、Baldridge Megan T.、Qaqish Arwa M.、Nice Timothy J.、Darbandi Azad D.、 Hartley Victoria L.、Peterson Stefan T.、Miner Jonathan J.、Iwai Kazuhiro、Virgin Herbert W.
- Journal Title
  
  Journal of Virology
  
  Volume: 92
- DOI
  10.1128/jvi.01368-18
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05499, KAKENHI-PROJECT-17H06174
[Journal Article] Cooperative domain formation by homologous motifs in HOIL-1L and SHARPIN plays crucial roles in LUBAC stabilization.2018
- Author(s)
  Fujita Hiroaki、Tokunaga Akira、Shimizu Satoshi、Whiting Amanda L.、Aguilar-Alonso Francisco、Takagi Kenji、Walinda Erik、Sasaki Yoshiteru、Shimokawa Taketo、Mizushima Tsunehiro、Ohki Izuru、Ariyoshi Mariko、Tochio Hidehito、Bernal Federico、Shirakawa Masahiro、Iwai Kazuhiro
- Journal Title
  
  Cell reports
  
  Volume: 23 Pages: 1192-1204
- DOI
  10.1016/j.celrep.2018.03.112
- NAID
  120006460107
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06969, KAKENHI-PROJECT-18K06083, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-17H06174, KAKENHI-PUBLICLY-17H06002, KAKENHI-PROJECT-17K15594
[Journal Article] HOIL-1L-mediated PKCζ degradation stabilizes plasma membrane Na,K-ATPase to protect against hypoxia-induced lung injury.2017
- Author(s)
  Magnani, N.D., Dada, D.A., Queisser, M,A., Brazee, P., Welch, L,C., Anekalla, K., Zhou, G., Misharin, A., Budinger, G.R.S., Iwai, K., Ciechanover, A.J., and Sznajder J.I.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA.
  
  Volume: 114 Pages: 10178-10186
- DOI
  10.1073/pnas.1713563114
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-17H06078, KAKENHI-PROJECT-17H06174
[Journal Article] Ubiquitination of exposed glycoproteins by SCFFBX027 directs damaged lysosomes for autophagy.2017
- Author(s)
  Yoshida, Y., Yasuda, S., Fujita, T., Hamasaki, M., Murakami, A., Kawawaki, J., Iwai, K., Saeki, Y., Yoshimori, T., Matsuda, N., and Tanaka, K
- Journal Title
  
  Proc Natl Acad Sci USA
  
  Volume: 114 Pages: 8574-8579
- DOI
  10.1073/pnas.1702615114
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07705, KAKENHI-WRAPUP-17H06078, KAKENHI-PLANNED-25111002, KAKENHI-PROJECT-17H06174, KAKENHI-PROJECT-15H04371, KAKENHI-PROJECT-26000014
[Journal Article] HTLV-1 Tax induces formation of the active macromolecular IKK complex by generating Lys63- and Metl-linked hybrid polyubiquitin chains.2017
- Author(s)
  Shibata, Y., Tokunaga, F., Goto, E., Komatsu, G., Gohda, J., Saeki, Y., Tanaka, K., Takahashi, H., Sawasaki, T., Inoue, S., Oshiumi, H., Seya, T., Nakano, H., Tanaka, Y., Iwai, K., and Inoue, JI.
- Journal Title
  
  PLoS Pathog.
  
  Volume: 13 Issue: 12
- DOI
  10.1371/journal.ppat.1006162
- NAID
  120005980879
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01553, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PLANNED-26110003, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26290036, KAKENHI-PROJECT-15K15353, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08517, KAKENHI-PROJECT-16K01378, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-26000014
[Journal Article] Roles of the NF-kappaB Pathway in B-Lymphocyte Biology.2016
- Author(s)
  Sasaki, Y. and Iwai, K.
- Journal Title
  
  Curr. Top. Microbiol. Immunol.
  
  Volume: 393 Pages: 177-209
- DOI
  10.1007/82_2015_479
- Data Source
  KAKENHI-PROJECT-26460573, KAKENHI-ORGANIZER-24112001
[Journal Article] Survival of mature T cells depends on signaling through HOIP.2016
- Author(s)
  Okamura, K., Kitamura, A., Sasaki, Y., Chung, D.H., Kagami, S., Iwai, K., and Yasutomo, K.
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 36135-36135
- DOI
  10.1038/srep36135
- NAID
  120005867034
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-26460573
[Journal Article] Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis2016
- Author(s)
  Nakazawa S, Oikawa D, Ishii R, Ayaki T, Takahashi H, Takeda H, Ishitani R, Kamei K, Takeyoshi I, Kawakami H, Iwai K, Hatada I, Sawasaki T, Ito H, Nureki O, and Tokunaga F.
- Journal Title
  
  Nat Commun
  
  Volume: 7 Pages: 12547-12547
- DOI
  10.1038/ncomms12547
- NAID
  120006323739
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-16H01192, KAKENHI-PLANNED-16H06575, KAKENHI-PLANNED-16H06579, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-15H04270, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-25291011, KAKENHI-PROJECT-15K18468, KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-16K15210, KAKENHI-PROJECT-16K18383
[Journal Article] Differential involvement of the NZF domains of SHARPIN and HOIL-1L in LUBAC-mediated cell death protection2016
- Author(s)
  Shimizu S, Fujita H, Sasaki Y, Tsuruyama T, Fukuda K, Iwai K.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 01049-15 Pages: 1569-1583
- DOI
  10.1128/mcb.01049-15
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19007, KAKENHI-PROJECT-14J01829, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-26460573
[Journal Article] Immunoblot analysis of linear polyubiquitination of NEMO.2015
- Author(s)
  Sasaki, Y., Fujita, H., Nakai, M., and Iwai, K.
- Journal Title
  
  Methods. Mol. Biol.
  
  Volume: 1280 Pages: 297-309
- DOI
  10.1007/978-1-4939-2422-6_17
- Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460573, KAKENHI-PROJECT-15K19007, KAKENHI-ORGANIZER-24112001
[Journal Article] The Structural differences between a glycoprotein specific F-box protein Fbsl and its homologous protein FBG32015
- Author(s)
  Kumanomidou, T., Nishio, K., Takagi, K., Nakagawa, T., Suzuki, A., Yamane, T., Tokunaga, F., Iwai, K., Murakami, A., Yoshida, Y., Tanaka, K., and Mizushima, T.
- Journal Title
  
  PRoS ONE
  
  Volume: 10
- DOI
  10.1371/journal.pone.0140366
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PUBLICLY-15H01172, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-26000014, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] Phenotypic complementation of genetic immunodeficiency by chronic herpesvirus infection.2015
- Author(s)
  MacDuff, D. A., Reese, T. A,, Kimmey, J. M., Weiss, L. A., Song, C., Zhang, X., Kambal, A., Duan, E., Carrero, J. A., Boisson, B., Laplantine, E., Israel, A., Picard, C., Colonna, M., Edelson, B. T., Sibley, L. D., Stallings, C. L., Casanova, J. L., Iwai, K., Virgin, H. W.
- Journal Title
  
  eLife
  
  Volume: 4
- DOI
  10.7554/elife.04494
- NAID
  120005997705
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] Gliotoxin Suppresses NF-κB Activation by Selectively Inhibiting Linear Ubiquitin Chain Assembly Complex(LUBAC)2015
- Author(s)
  Hiroki Sakamoto, Shinichiro Egashira, Nae Saito, Takayoshi Kirisako, Simon Miller, Yoshiteru Sasaki, Tadahiko Matsumoto, Manabu Shimonishi, Toru Komatsu, Takuya Terai, Tasuku Ueno, Kenjiro Hanaoka, Hirotatsu Kojima, Takayoshi Okabe, Soichi Wakatsuki, Kazuhiro Iwai, Tetsuo Nagano
- Journal Title
  
  ACS Chem. Biol.
  
  Volume: 10 Pages: 675-681
- DOI
  10.1021/cb500653y
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J11914, KAKENHI-PROJECT-22000006, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PUBLICLY-26104509, KAKENHI-PROJECT-26460573, KAKENHI-PROJECT-26670154, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-15H05371
[Journal Article] Posttranslational Modification of HOIP Blocks Toll-Like Receptor 4-Mediated Linear-Ubiquitin-Chain Formation.2015
- Author(s)
  Bowman, J., Rodgers, M.A., Shi, M., Amatya, R., Hostager, B., Iwai, K., Gao, S.J., and Jung, J.U.
- Journal Title
  
  MBio.
  
  Volume: 6
- DOI
  10.1128/mbio.01777-15
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] LUBAC formation is impaired in the livers of mice with MCD-dependent non-alcoholic steatohepatitis2015
- Author(s)
  Matsunaga Y, Nakatsu Y, Fukushima T, Okubo H, Iwashita M, Sakoda H, Fujishiro M, Yamamotoya T, Kushiyama A, Takahashi S, Tsuchiya Y, Kamata H, Tokunaga F, Iwai K, Asano T.
- Journal Title
  
  Mediators of Inflammation
  
  Volume: 2015 Pages: 10-10
- DOI
  10.1155/2015/125380
- NAID
  120005745641
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08259, KAKENHI-PROJECT-26460369, KAKENHI-PUBLICLY-15H01172, KAKENHI-PUBLICLY-15H01382, KAKENHI-PUBLICLY-15H01406, KAKENHI-PROJECT-15H04694, KAKENHI-PROJECT-25461372, KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25221204, KAKENHI-PROJECT-25253019
[Journal Article] Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system.2015
- Author(s)
  Sasaki, K. and Iwai, K.
- Journal Title
  
  Immunol. Rev.
  
  Volume: 266 Pages: 175-189
- DOI
  10.1111/imr.12308
- NAID
  120005672572
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] CYLD and the NEMO zinc finger regulate tumor necrosis factor signaling and early embryogenesis.2015
- Author(s)
  Zhao, Y., Ma, C. A., Wu, L., Iwai, K., Ashwell, J. D., Oltz, E. M., Ballard, D. W., and Jain, A.
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Pages: 22076-22084
- DOI
  10.1074/jbc.m115.658096
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26670154, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates2015
- Author(s)
  Morimoto, D., Walinda, E. Fukada, H., Sou, Y. S., Kageyama, S., Hoshino, M., Fujii, T., Tsuchiya, H., Saeki, Y., Arita, K., Ariyoshi, M., Tochio, H., Iwai, K., Namba, K., Komatsu, M., Tanaka, K., and Shirakawa M.
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  Nat Commun.
  
  Volume: 6 Pages: 000-000
- DOI
  10.1038/ncomms7116
- NAID
  120005528125
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-21121006, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-25000013, KAKENHI-PLANNED-25111006, KAKENHI-PUBLICLY-25112514, KAKENHI-PLANNED-26119004, KAKENHI-PROJECT-26440025, KAKENHI-PROJECT-26860224, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-26000014
[Journal Article] Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms.2014
- Author(s)
  Yang, Y., Schmitz, R., et al.
- Journal Title
  
  Cancer Discov.
  
  Volume: 4 Pages: 480-493
- DOI
  10.1158/2159-8290.cd-13-0915
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-24659136, KAKENHI-PROJECT-25253019
[Journal Article] Mechanism underlying IKK activation mediated by the linear ubiquitin2014
- Author(s)
  Fujita, H., Rahighi, S., Akita, M., Kato, R., Sasaki, Y., Wakatsuki, S., and Iwai, K.
- Journal Title
  
  Mol Cell Biol.
  
  Volume: 34 Pages: 1322-1335
- DOI
  10.1128/mcb.01538-13
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112009, KAKENHI-PROJECT-24659136, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-26460573
[Journal Article] The linear ubiquitin assembly complex (LUBAC) is essential for NLRP3 inflammasome activation.2014
- Author(s)
  Rodgers, M. A., Bowman, J., Fujita, H., Orazio, N., Shi, M., Liang, Q., Amatya, R., Kelly, T. J., Iwai, K., Ting, J., and Jung, J. U.
- Journal Title
  
  J. Exp. Med.
  
  Volume: 211 Pages: 1333-1347
- DOI
  10.1084/jem.20132486
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] Suppression of LUBAC-mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN2014
- Author(s)
  Takiuchi, T., Nakagawa, T., Tamiya, H., Fujita, H., Sasaki, Y., Saeki, Y., Takeda, H., Sawasaki, T., Buchberger, A., Kimura, T., and Iwai. K.
- Journal Title
  
  Genes Cells
  
  Volume: 19 Pages: 254-272
- DOI
  10.1111/gtc.12128
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PLANNED-24112008, KAKENHI-PROJECT-24659136, KAKENHI-PROJECT-24790279, KAKENHI-PROJECT-25253019
[Journal Article] HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth.2014
- Author(s)
  Queisser, M. A., Dada, L. A., Deiss-Yehiely, N., Angulo, M., Zhou, G., Kouri, F. M., Knab, L. M., Liu, J., Stegh, A. H., DeCamp, M. M., Budinger, G. R., Chandel, N. S., Ciechanover, A., Iwai, K., and Sznajder, J. I.
- Journal Title
  
  Am. J. Respir. Crit. Care Med.
  
  Volume: 190 Pages: 688-698
- DOI
  10.1164/rccm.201403-0463oc
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-25253019
[Journal Article] IFN-γ or IFN-α Ameliorates Chronic Proliferative Dermatitis by Inducing Expression of Linear Ubiquitin Chain Assembly Complex2014
- Author(s)
  Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, and Iwai K.
- Journal Title
  
  Journal of Immunology.
  
  Volume: 192 Pages: 3793-3804
- DOI
  10.4049/jimmunol.1302308
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-24689045, KAKENHI-PROJECT-26460573, KAKENHI-PROJECT-25253019
[Journal Article] IFN-γor IFN-αameliorates chronic proliferative dermatitis by inducing expression of linear ubiquitin chain assembly complex2014
- Author(s)
  Tamiya H, Terao M, Takiuchi T, Nakahara M, Sasaki Y, Katayama I, Yoshikawa H, and Iwai K
- Journal Title
  
  J. Immunol.
  
  Volume: 192 Pages: 3793-3804
- Data Source
  KAKENHI-PROJECT-24659136
[Journal Article] Linear ubiquitin chains: NF-κB signaling, cell death and beyond.2014
- Author(s)
  Iwai, K., Fujita, H., and Sasaki, Y.
- Journal Title
  
  Nat. Rev. Mol. Cell Biol.
  
  Volume: 15 Pages: 503-508
- DOI
  10.1038/nrm3836
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-26460573
[Journal Article] Ubiquitin chain elongation: An intriguing strategy.2014
- Author(s)
  Iwai, K. and Tanaka, K.
- Journal Title
  
  Molecular Cell
  
  Volume: 56
- DOI
  10.1016/j.molcel.2014.10.009
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002
[Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells.2013
- Author(s)
  Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, T., and lwai, K.
- Journal Title
  
  EMBO J
  
  Volume: 32 Pages: 2463-2476
- DOI
  10.1038/emboj.2013.184
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-21000012, KAKENHI-PROJECT-21229007, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-24659136, KAKENHI-PROJECT-25221102, KAKENHI-PROJECT-25253019
[Journal Article] IOP1 protein is an external component of human cytosolic iron-sulfur cluster assembly (CIA) machinery and functions in MMS19 protein-dependent CIA pathway.2013
- Author(s)
  Mineaki Seki, Yukiko Takeda, Kazuhiro Iwai and Kiyoji Tanaka
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 16680-16689
- DOI
  10.1074/jbc.m112.416602
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-22131009, KAKENHI-PROJECT-22510061, KAKENHI-ORGANIZER-24112001, KAKENHI-PROJECT-25253019
[Journal Article] Two coordinated mechanisms underlie TNFα-induced immediate and delayed IKK activation.2013
- Author(s)
  Blackwell, K., Zhang, L., Workman, L.M., Ting, A.T., Iwai, K., Habelhah, H.
- Journal Title
  
  Mol. Cell. Biol.
  
  Volume: 33 Pages: 1901-1915
- DOI
  10.1128/mcb.01416-12
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24112001, KAKENHI-PROJECT-25253019
[Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin.2013
- Author(s)
  Naonobu Fujita et al.
- Journal Title
  
  J Cell Biol
  
  Volume: 203 Pages: 115-128
- DOI
  10.1083/jcb.201304188
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22117006, KAKENHI-PROJECT-23247034, KAKENHI-PROJECT-23390070, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002, KAKENHI-PROJECT-24370077, KAKENHI-PROJECT-24659136, KAKENHI-PLANNED-25111002, KAKENHI-PUBLICLY-25117717, KAKENHI-PROJECT-25253019, KAKENHI-PROJECT-25293372, KAKENHI-PROJECT-25650073, KAKENHI-PROJECT-25670027, KAKENHI-PROJECT-25670137
[Journal Article] Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells2013
- Author(s)
  Sasaki, Y., Sano, S., Nakahara, M., Murata, S., Kometani, K., Aiba, Y., Sakamoto, S., Watanabe, Y., Tanaka, K., Kurosaki, K. and Iwai, K
- Journal Title
  
  EMBO J.
  
  Volume: 32 Pages: 2463-2476
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells2012
- Author(s)
  Tomonaga, M., Hashimoto, N., Tokunaga, F., Onishi, M., Myoui, A., Yoshikawa, H. and Iwai, K
- Journal Title
  
  Int. J. Oncol.
  
  Volume: 40 Pages: 409-417
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Linear ubiquitination of NEMO negatively regulates the interferon antiviral response through disruption of the MAVS-TRAF3 complex2012
- Author(s)
  Belgnaoui, S.M., Paz, S., Samuel, S., Goulet, M.L., Sun, Q., Kikkert, M., Iwai, K., Dikic, I., Hiscott, J. and Lin, R
- Journal Title
  
  Cell Host Microbe.
  
  Volume: 12(2) Pages: 211-222
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Activation of nuclear factor-kappa B by linear ubiquitin chain assembly complex contributes to lung metastasis of osteosarcoma cells.2012
- Author(s)
  Tomonoga, M., et al.
- Journal Title
  
  Ann Thorac Surg
  
  Volume: 40 Pages: 409-417
- DOI
  10.3892/ijo.2011.1209
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22117006, KAKENHI-PROJECT-22249008, KAKENHI-PROJECT-23390070, KAKENHI-PROJECT-23390364, KAKENHI-PROJECT-23657075
[Journal Article] Diverse ubiquitin signaling in NF-κB activation.2012
- Author(s)
  Iwai, K.
- Journal Title
  
  Trends Cell Biol.
  
  Volume: 22 Pages: 355-364
- DOI
  10.1016/j.tcb.2012.04.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249008, KAKENHI-PROJECT-24659136, KAKENHI-ORGANIZER-24112001, KAKENHI-PLANNED-24112002
[Journal Article] Non-canonical UBA–UBL interaction mediates formation of linear ubiquitin chain assembly complex2012
- Author(s)
  Yagi, H., Ishimoto, K., Takeshi Hiromoto, T., Fujita, H., Mizushima, T., Uekusa, Y., Yagi-Utsumi, M., Kurimoto, E., Noda, M., Uchiyama, S., Tokunaga, F., Iwai, K. (Correspondence author) and Kato, K
- Journal Title
  
  EMBO Rep.
  
  Volume: 13 Pages: 462-468
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Analysis of Nuclear factor-κB (NF-κB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-κB2012
- Author(s)
  Kensche, T., Tokunaga, F., Ikeda, F., Goto, E., Iwai, K. and Dikic, I
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287(28) Pages: 23626-23634
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation2012
- Author(s)
  Tokunaga, F., Nishimasu, H., Ishitani, R., Goto, E., Noguchi, T., Mio, K., Kamei, K., Ma, A., Iwai, K. and Nureki, O
- Journal Title
  
  EMBO J.
  
  Volume: 31(19) Pages: 3856-3870
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] SHARPIN is a component of the NF-kB activating linear ubiquitin assembly complex.2011
- Author(s)
  Tokunaga F., Nakagawa T., Nakahara M., Saeki Y., Taniguchi M., S Sakata S.-i., Tanaka K., Nakano H., Iwai K.
- Journal Title
  
  Nature 471
  
  Pages: 633-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] SHARPIN is a component of the NF-B activating linear ubiquitin chain assembly complex2011
- Author(s)
  Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sataka, S.-I., Tanaka, K., Nakano, H., and Iwai, K
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 633-636
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis2011
- Author(s)
  Ikeda, F., Deribe, Y. L., Skånland, S.S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S.J.L., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, J.P., Rittinger, K., Schaefer, L., Macek, B. and Dikic, I
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 637-641
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] SHARPIN is a component of the NF-κB activating linear ubiquitin chain assembly complex.2011
- Author(s)
  Tokunaga, F., Nakagawa, T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., Iwai, K.
- Journal Title
  
  Nature 471
  
  Pages: 633-636
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.2011
- Author(s)
  Ikeda, F., Deribe, Y.L., Skanland, S.S., Stieglitz, B., Grabbe, C., Franz-Wachtel, M., van Wijk, S.J.L., Goswami, P., Nagy, V., Terzic, J., Tokunaga, F., Androulidaki, A., Nakagawa, T., Pasparakis, M., Iwai, K., Sundberg, J.P., Rittinger, K., Schaefer, L., Macek, B., Dikic, I.
- Journal Title
  
  Nature 471
  
  Pages: 637-641
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.2011
- Author(s)
  Ikeda F., Deribe Y.L, Skanland S.S., Stieglitz B., Grabbe C., van WijK S., Franz-Wachtel M., Goswami P., Nagy V., Terzic J., Tokunaga F., Androulidaki A., Nakagawa T., Pasparakis M., Iwai K., Sundberg J.P., Schaefer L., Macek B., Rittinger K., Dikic, I.
- Journal Title
  
  Nature 471
  
  Pages: 637-641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO2011
- Author(s)
  Niu, J., Shi, Y., Iwai, K. and Wu, Z.-H
- Journal Title
  
  EMBO J.
  
  Volume: 30 Pages: 3741-3753
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex.2011
- Author(s)
  Tokunaga, F., Nakagawa T., Nakahara, M., Saeki, Y., Taniguchi, M., Sakata, S.-I., Tanaka, K., Nakano, H., Iwai, K.
- Journal Title
  
  Nature
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-1 interferon induction2011
- Author(s)
  Inn, K.-S., Gack, M.U., Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K.,(責任著者), Jung, J.U.
- Journal Title
  
  Molecular Cell
  
  Volume: 41 Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Sharpin is a component of the NF-κB activating linear ubiquitin chain assembly complex2011
- Author(s)
  Tokunaga, F., Nakagawa T., Nakahara, M., Saeki, Y., Taniguchi, M., Sataka, S.-I., Tanaka, K., Nakano, H., Iwai, K.
- Journal Title
  
  Nature
  
  Volume: 471 Pages: 633-636
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Specific Recognition of Linear Ubiquitin Chains by the HOIL-1L NZF domain2011
- Author(s)
  Sato, Y., Fujita, H., Yoshikawa, A.,Yamashita, M., Yamagata, A., Kaiser, S. E., Iwai, K., and Fukai, S
- Journal Title
  
  Proc. Natl. Acad. Sci.
  
  Volume: USA 108 Pages: 20520-20525
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ub iquitination of NEMO2011
- Author(s)
  Niu, J., Shi, Y., Iwai, K., Wu, Z.-H.
- Journal Title
  
  EMBO J
  
  Volume: 30(18) Pages: 3741-3753
- DOI
  10.1038/emboj.2011.264
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-I interferon induction.2011
- Author(s)
  Inn, K.-S., Gack, M.U. Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K., (責任者著), Jung, J.U.
- Journal Title
  
  Molecular Cell
  
  Volume: 41 Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.2011
- Author(s)
  Inn K.S., Gack M.U., Tokunaga F., Shi M., Wong L.Y., Iwai K., Jung J.U.
- Journal Title
  
  Mol Cell 41
  
  Pages: 354-365
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex2011
- Author(s)
  Sato, Y., Fujita, H., Yoshikawa, A., Yamashita, M., Yamagata, A., Kaiser, S. E., Iwai, K., Fukai, S
- Journal Title
  
  Proc.Natl.Acad.Sci.
  
  Volume: 108巻 Pages: 20520-20525
- DOI
  10.1073/pnas.1109088108
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21687009, KAKENHI-PLANNED-22121003, KAKENHI-PROJECT-22249008, KAKENHI-PROJECT-22770099, KAKENHI-PROJECT-22770100, KAKENHI-PUBLICLY-23117514
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I-and TRIM25-mediated type-I interferon induction.2011
- Author(s)
  Inn, K.-S., Gack, M.U.Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K., (corresponding author) Jung, J.U.
- Journal Title
  
  Molecular Cell 41
  
  Pages: 354-365
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type-I interferon induction2011
- Author(s)
  Inn, K.-S., Gack, M. U. Tokunaga, F., Shi, M., Wong, L.-Y., Iwai, K. (corresponding author) and Jung, J. U
- Journal Title
  
  Molecular Cell
  
  Volume: 41 Pages: 354-365
- Data Source
  KAKENHI-PROJECT-22249008
[Journal Article] ユビキチン修飾系によるNF-κBグナル伝達制御:新規直鎖状ポリユビキチン鎖形成を介するNF-κB制御機構の発見2010
- Author(s)
  徳永文稔、岩井一宏
- Journal Title
  
  細胞工学 29
  
  Pages: 1224-1230
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Crystallization and prelimiary X-ray characterization of the Skp1-Fbg3 complex.2010
- Author(s)
  Kumanomidou T., Nakagawa T., Mizushima T., Suzoki A., Tokunaga F., Iwai K., Yoshida Y., Tanaka K., Yamane T.
- Journal Title
  
  Acta Crystallogr.Sect.F Struct.Biol.Cryst.Commun 66
  
  Pages: 95-98
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] NEMOの直鎖状ポリユビキチン化修飾によるNF-κB活性化2009
- Author(s)
  徳永文稔、岩井一宏
- Journal Title
  
  蛋白質核酸酵素 54
  
  Pages: 635-642
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Involvement of linear polyubiquitination of NEMO in NF-κB activation.2009
- Author(s)
  Tokunaga, F., Sakata, S.-I., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K.Iwai, K.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear polyubiquitination : a new regulator of NF-kB activation2009
- Author(s)
  Iwai K., Tokunaga F.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20059031
[Journal Article] アレルギーやガンに関わるNF-κBの新しい活性化機構の発見:新規ユビキチン修飾2009
- Author(s)
  岩井一宏、坂田真一、中川朋子、徳永文稔
- Journal Title
  
  直鎖状ポリユビキチン化によるNF-κB活性化.化学と生物 47
  
  Pages: 602-604
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Involvement of linear polyubiquitylation of NEMO in NF-κB activation.2009
- Author(s)
  Tokunaga F., Sakata S.-i., Saeki Y., Satomi Y., Kirisako T., Kamei K., Nakagawa T., Kato M., Murata S., Yamaoka S., Yamamoto M., Akira S., Takao T., Tanaka K., Iwai K.
- Journal Title
  
  Nature Cell Biol. 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Linear polyubiquitination : a new regulator of NF-κB activation.2009
- Author(s)
  Iwai, K., Tokunaga, F.
- Journal Title
  
  EMBO Rep 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Involvement of linear polyubiquitinatioh of NEMO in NF-κB activation2009
- Author(s)
  Tokunaga, F., Sakata, Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato,_M., Murata, S., Yamaoka, S., Yamamoto, M., Akira, S., Takao, T., Tanaka, K., and Iwai K.
- Journal Title
  
  Nature Cell Biology 11
  
  Pages: 123-132
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Coordination of PGC-1b and iron uptake in mitochondrial biogenesis and osteoclast activation.2009
- Author(s)
  Ishii, K., Fumoto, T., Iwai, K., et al.
- Journal Title
  
  Nature Medicine 15
  
  Pages: 259-266
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Linear polyubiquitination : a new regulator of NF-κB activation2009
- Author(s)
  Iwai K., Tokunaga F.
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Linear polyubiquitination : a new regulator of NF-kB activation.2009
- Author(s)
  岩井一宏, 徳永文稔
- Journal Title
  
  EMBO Rep. 10
  
  Pages: 706-713
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase.mediated hypoxia inducible factor-α ubiquitination.2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 16622-16631
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Hypoxia-mediated Na-K-ATPase degradation requires von Hippel Lindau protein.2008
- Author(s)
  Zhou, G., Dada, L.A., Chandel, N.S., Iwai, K., Lecuona, E., Ciechanover, A., Sznajder, J.I.
- Journal Title
  
  FASEB J. 22
  
  Pages: 1335-1342
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Gp78 Cooperates with RMA1 in ER-associated Degradation of CFTRΔF508.2008
- Author(s)
  Morito, D., Hirao, K., Oda, Y., Hosokawa, N., Tokunaga, F., Cyr, D.M., Tanaka, K., Iwai, K., Nagata K.
- Journal Title
  
  Mol.Biol.Cell. 19
  
  Pages: 1328-1336
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-α ubiquitination2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., and Iwai, K.
- Journal Title
  
  J. Biol. Chem 283
  
  Pages: 16622-16631
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Structural basis for specific cleavage of Lys63-linked polyubiquitin chains.2008
- Author(s)
  Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai, K., Komada, M., Fukai, S.
- Journal Title
  
  Nature 455
  
  Pages: 358-362
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] ユビキチン修飾によるタンパク質機能制御機構の分子基盤2008
- Author(s)
  岩井一宏
- Journal Title
  
  実験医学 26
  
  Pages: 2356-2361
- Data Source
  KAKENHI-ORGANIZER-18076008
[Journal Article] Structural basis for specific cleavage of Lys63-linked polyubiquitin chains2008
- Author(s)
  Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai. K., Komada, M., and Fukai, S.
- Journal Title
  
  Nature 455
  
  Pages: 358-362
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] The COP9/signalosome increases the efficiency of von Hippel-Linubiquitin ligase-mediated hypoxia-inducible factor-alpha ubiquitination.2008
- Author(s)
  Miyauchi Y., Kato M., Tokunaga F., Iwai K.
- Journal Title
  
  J.Biol.Chem. 283
  
  Pages: 1662-16631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] Structural basis for specific cleavage of Lys63-linked polyubiquitin chains2008
- Author(s)
  Sato, Y., Yoshikawa, A., Yamagata, A., Mimura, H., Yamashita, M., Ookata, K., Nureki, O., Iwai, K., Komada, M., and Fukai, S.
- Journal Title
  
  Nature 455
  
  Pages: 358-362
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] ユビキチン2008
- Author(s)
  岩井一宏
- Journal Title
  
  蛋白質核酸酵素 53
  
  Pages: 1012-1012
- Data Source
  KAKENHI-ORGANIZER-18076008
[Journal Article] 鉄代謝を制御するタンパク質分解システム2008
- Author(s)
  岩井一宏
- Journal Title
  
  癌と化学療法 35
  
  Pages: 16-20
- Data Source
  KAKENHI-ORGANIZER-18076008
[Journal Article] gp78 cooperates with RMA1 in ER-associadegradation of CFTRDF508.2008
- Author(s)
  Morito D., Hirao K., Oda Y., Hosokawa N., Tokunaga F., Cyr D.M., Tanaka K., Iwai K., Nagata K.
- Journal Title
  
  Mol.Biol.Cell 19
  
  Pages: 1328-1336
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390097
[Journal Article] The COP9/signalosome increases the efficiency of pVHL ubiquitin ligase-mediated hypoxia inducible factor-a ubiquitination2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
- Journal Title
  
  J. Biol. Chem. 283
  
  Pages: 16622-16631
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity2007
- Author(s)
  Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K. Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K., Kato, K.
- Journal Title
  
  Nature Struct. Mol. Biol. 14
  
  Pages: 167-168
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] A neural-specific F-box protein Fbsl functions as a chaperone suppressing glycoprotein aggregation2007
- Author(s)
  Yoshida, Y., Murakami, A., Iwai, K., Tanaka, K.
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 7137-7144
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Direct interactions between Nedd8 and uE2 conjugating enzymes contribute up-regulation of cullin-based E3 ligase activity.2007
- Author(s)
  Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K.Kato, K.
- Journal Title
  
  Nature Struct.Mol.Biol. 14:
  
  Pages: 167-168
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Ubiquitin is degraded by the ubiquitin system as a monomer and as part of its conjugated target.2007
- Author(s)
  Shabek, N., Iwai, K., Ciechanover, A.
- Journal Title
  
  Biochem Biophys Res Commun. 363
  
  Pages: 425-431
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Herne induces ubiquitination and degradation of the transcription factor Bachl2007
- Author(s)
  Zenke-Kawasaki, Y., Dohi, Y., Katoh, Y., Ikura, T., lkura, M., Asahara, T., Tokunaga, F., Iwai, Igarashi, K.
- Journal Title
  
  Mol. Cell Biol. 27
  
  Pages: 6962-6971
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contribute to up-regulation of cullin-based E3 ligase activity.2007
- Author(s)
  Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K., Chiba, T., Saeki, Y., Matsuda, N., Tanaka, K., Kato, K.
- Journal Title
  
  Nat. Struct. Mol. Biol. 14・2
  
  Pages: 167-168
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.2007
- Author(s)
  Yoshida, Y., Murakami, A., Iwai, K., Tanaka, K.
- Journal Title
  
  J.Biol.Chem. 282・10
  
  Pages: 7137-7144
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] A neural-specific F-box protein Fbs1 functions as a chaperone suppressing glycoprotein aggregation.2007
- Author(s)
  Yoshida, Y., Murakami, A., Iwai, K., Tanaka, K.
- Journal Title
  
  J. Biol. Chem. 282・10
  
  Pages: 7137-7144
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Mechanism Underlying the Iron-Dependent Nuclear Export of the Iron-Responsive Transcription Factor Aft1p in Saccharomyces Cervisiae2007
- Author(s)
  Fujiwara N., Ueta R., Iwai K., Yamaguchi-Iwai Y.
- Journal Title
  
  Molecular Biology of the Cell (In revision)
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Direct interactions between Nedd8 and ubiquitin E2 conjugating enzymes contibute to up-regulation of cullin-based E3 ligase activity.2007
- Author(s)
  Sakata, E., Yamaguchi, Y., Miyauchi, Y., Iwai, K.Chiba, T., Sacki, Y., Matsuda, N., Tanaka, K., Kato, K.
- Journal Title
  
  Nat.Struct.Mol.Biol. 14・2
  
  Pages: 167-168
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Neural-specific F-box protein Fbsl functions as a chaperone suppressing glycoprotein aggregation.2007
- Author(s)
  Yoshida, Y., Murakami, A., Iwai. K. and Tanaka, K. A
- Journal Title
  
  J. Biol. Chem. 282
  
  Pages: 7137-7144
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells2006
- Author(s)
  Wang, D., Masutani, H., Oka, S.I., Tanaka T., Yamaguchi-Iwai, Y., Nakamura, H., Yodoi, J.
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 7384-7391
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells.2006
- Author(s)
  Wang, D., Masutani, H., Oka, S.I., Tanaka, T., Yamaguchi-Iwai, Y., Nakamura, H., Yodoi, J.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 7384-7391
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Zinc Transport Complexes Contribute to the Homeostatic Maintenance of Secretory Pathway Function in Vertebrate Cells2006
- Author(s)
  Ishihara K., Yamazaki T., Ishida Y., Suzuki T., Oda K., Nagao M., Yamaguchi-Iwai Y., Kambe T.
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 17743-17750
- Data Source
  KAKENHI-PROJECT-18055016
[Journal Article] Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters2006
- Author(s)
  Kambe T., Suzuki T., Nagao M., Yamaguchi-Iwai Y.
- Journal Title
  
  Genomics, Proteomics ＆ Bioinformatics 4
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-18055016
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex(LUBAC).2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sokoto, S.-I. and Iwai, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351
  
  Pages: 340-347
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells.2006
- Author(s)
  Wang, D., Masutani, H., Oka, S.I., Tanaka, T., Yamaguchi-Iwai, Y., Nakamura.H., Yodoi, J.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 7384-7391
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells.2006
- Author(s)
  Ishihara, K, Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J. Biol. Chem 281
  
  Pages: 17743-17750
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Chemoenzymatic Ubiquitination of Artificial Substrates.2006
- Author(s)
  Barchak, O.N., Jaquinod, M., Cottin, C., Mugherli, L., Iwai, K., Chatelain, F., Balakirev, M.Y.
- Journal Title
  
  Chembiochem. 7・11
  
  Pages: 1667-1669
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Zinc Transport Complexes Contribute to the Homeostatic Maintenance of Secretory Pathway Function in Vertebrate Cells2006
- Author(s)
  Ishihara K., Yamazaki T., Ishida Y., Suzuki T., Oda K., Nagao, M., Yamaguchi-Iwai Y., Kambe T.
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 17743-17750
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Studies of the ubiquitin proteasome system. Units 15.9 Sections 1-12.2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K., Weissman, A. M.
- Journal Title
  
  Current Protocols in Cell Biology Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, eds. John Wiley and Sons 75
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.2006
- Author(s)
  Bayle, J., Lopez, S., Iwai, K., Dubreuil, P., De Sepulveda, P.
- Journal Title
  
  FEBS Lett. 580・11
  
  Pages: 2609-2614
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Studies of the ubiquitin proteasome system2006
- Author(s)
  Lorick, K., Yang, Y., Jensen, J., Iwai, K.and Weissman, A.M.
- Journal Title
  
  Units 15.9 Sections 1-12.Current Protocols in Cell Biology, Bonifacino J, Dasso M, Lippincott-Schwartz J, Harford J, Yamada K, eds.John Wiley and Sons
  
  Pages: 75-75
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells.2006
- Author(s)
  Wang, D., Masutani, H., Oka, S.I., Tanaka, T., Yamaguchi-Iwai, Y., Nakamura, H., Yodoi, J.
- Journal Title
  
  J.Biol.Chem. 281(in press)
- Data Source
  KAKENHI-PROJECT-17054019
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains.2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S., Tokunaga, F., Tanaka, K., Iwai, K.
- Journal Title
  
  EMBO J. 25・20
  
  Pages: 4877-4887
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC)2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sakata , S.-I., Iwai, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351
  
  Pages: 340-347
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Chemoenzymatic Ubiquitination of Artificial Substrates.2006
- Author(s)
  Burchak, O.N., Jaquinod, M., Cottin, C., Mugherli, L., Iwai, K., Chatelain, F., Balakirev.M.Y.
- Journal Title
  
  Chembiochem. 7・11
  
  Pages: 1667-1669
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Zinc transport complexes contribute to the homeostatic maintenance of secretory pathway function in vertebrate cells2006
- Author(s)
  Ishihara, K, Yamazaki, T., Ishida, Y., Suzuki, T., Oda, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J. Biol. Chem. 281
  
  Pages: 17743-17750
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains.2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S.Tokunaga, F., Tanaka, K.Iwai, K.
- Journal Title
  
  EMBO J. 25
  
  Pages: 4877-4887
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex(LUBAC).2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sakata, S.-I., Iwai, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 351・2
  
  Pages: 340-347
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin ligase complex (LUBAC).2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sakata, S.-I., Iwai, K.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 351・2
  
  Pages: 340-347
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains2006
- Author(s)
  Kirisako, T., Katnei, K., Murata, S., Kato, M., Fukumoto., H, , Kanie, K., Sano, S.Tokunaga, F., Tanaka, K.and Iwai, K.
- Journal Title
  
  EMBO J. 25・20
  
  Pages: 4877-4887
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters.2006
- Author(s)
  Kambe, T., Suzuki, T., Nagao, M., Yamaguchi-Iwai, Y.
- Journal Title
  
  Genomics Proteomics Bioinformatics. 4
  
  Pages: 1-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.2006
- Author(s)
  Bayle, J., Lopez, S., Iwai, K., Dubreuil, P., De Sepulveda, P.
- Journal Title
  
  FEBS Lett. 580・11
  
  Pages: 2609-2614
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters.2006
- Author(s)
  Kambe, T., Suzuki, T., Nagao, M., Yamaguchi- Iwai, Y.
- Journal Title
  
  Genomics Proteomics Bioinformatics. 4
  
  Pages: 1-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Mutual regulation of conventional protein kinase C and a ubiquitin liease complex(LUBAC)2006
- Author(s)
  Nakamura, M., Tokunaga, F., Sakata, S.-I.and Iwai, K.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 351・2
  
  Pages: 340-347
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains.2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S. Tokunaga, F., Tanaka, K., Iwai, K.
- Journal Title
  
  EMBO J. 25
  
  Pages: 4877-4887
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells2006
- Author(s)
  Wang, D., Masutani, H., Oka, S.I., Tanaka, T., Yamaguchi-Iwai, Y., Nakamura, H., Yodoi, J.
- Journal Title
  
  The Journal of Biological Chemistry 281
  
  Pages: 7384-7391
- Data Source
  KAKENHI-PROJECT-18055016
[Journal Article] A ubiquitin ligase complex assembles linear polyubiquitin chains.2006
- Author(s)
  Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, K., Sano, S., Tokunaga, F., Tanaka.K., Iwai.K.
- Journal Title
  
  EMBO J. 25・20
  
  Pages: 4877-4887
- Data Source
  KAKENHI-PLANNED-18076004
[Journal Article] Sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters2006
- Author(s)
  Kambe T., Suzuki T., Nagao M., Yamaguchi-Iwai Y.
- Journal Title
  
  Genomics, Proteomics ＆ Bioinformatics 4
  
  Pages: 1-9
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Control of mitochondrial outer membrane permeabilization and Bcl-xL levels by thioredoxin 2 in DT40 cells.2006
- Author(s)
  Wang, D., Masutani, H., Oka, S.I., Tanaka, T., Yamaguchi-Iwai, Y., Nakamura, H., Yodoi, J.
- Journal Title
  
  J.Biol.Chem. 281(in press)
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphates in vertebrate cells.2005
- Author(s)
  Suzuki, T, Ishihara, K., Migaki, H., Ishihara, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 30956-30962
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1.2005
- Author(s)
  Iwai, K., Ishikawa, H., Kirisako, T.
- Journal Title
  
  Methods Enzymol. 398
  
  Pages: 256-271
- Data Source
  KAKENHI-PROJECT-17054019
[Journal Article] Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1.2005
- Author(s)
  Iwai, K., et al.
- Journal Title
  
  Methods Enzymol 398
  
  Pages: 256-271
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatase in vertebrate cells.2005
- Author(s)
  Suzuki, T, Ishihara, K., Migaki, H., Ishihara, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 30956-30962
- Data Source
  KAKENHI-PROJECT-17054019
[Journal Article] Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.2005
- Author(s)
  Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., Iwai, K.
- Journal Title
  
  Molecular Cell 19
  
  Pages: 171-181
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.2005
- Author(s)
  Suzuki, T, Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 637-643
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.2005
- Author(s)
  Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., Iwai, K.
- Journal Title
  
  Mol.Cell. 19
  
  Pages: 171-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] 2004年度ノーベル化学賞ユビキチン依存性タンパク質分解幾構の発見2005
- Author(s)
  岩井一宏
- Journal Title
  
  現代化学 406
  
  Pages: 31-34
- Data Source
  KAKENHI-PROJECT-12146202
[Journal Article] Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.2005
- Author(s)
  Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., Iwai, K.
- Journal Title
  
  Mol Cell 19
  
  Pages: 171-181
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.2005
- Author(s)
  Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 637-643
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Zinc transporters, ZnT5, ZnT7 are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane.2005
- Author(s)
  Suzuki, T., Ishihara, K., Migaki, H., Matsuura, W., Kohda, A., Okumura, K., Nagao, M., Yamaguchi- Iwai, Y., Kambe, T.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 637-643
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.2005
- Author(s)
  Measday, V., Baetz, K., Guzzo, J., Yuen, K., Kwok, T., Sheikh, B., Ding, H., Ueta, R., Hoac, T., Cheng, B., Pot, I., Tong, A., Yamaguchi-Iwai, Y., Boone, C., Hieter, P., Andrews, B.
- Journal Title
  
  Proc.Natl.Acad.Sci. USA 102
  
  Pages: 13956-13961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.2005
- Author(s)
  Suzuki, T., Ishihara, K., Migaki, H., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J.Biol.Chem. 280
  
  Pages: 30956-30962
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Invovlement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.2005
- Author(s)
  Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., Iwai, K.
- Journal Title
  
  Molecular Cell. 19
  
  Pages: 171-181
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP2.2005
- Author(s)
  Ishikawa, H., Kato, M., Hori, H., Ishimori, K., Kirisako, T., Tokunaga, F., Iwai, K.
- Journal Title
  
  Molecular Cell 19
  
  Pages: 171-181
- Data Source
  KAKENHI-PROJECT-17054019
[Journal Article] Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.2005
- Author(s)
  Measday, V., Baetz, K., Guzzo, J., Yuen, K., Kwok, T., Sheikh, B., Ding, H., Ueta, R., Hoac, T., Cheng, B., Pot, I., Tong, A., Yamaguchi-Iwai, Y., Boone, C., Hieter, P., Andrews, B.
- Journal Title
  
  Proc.Natl.Acad.Sci. 102
  
  Pages: 13956-13961
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Two different zinc transport complexes of cation diffusion facilitator proteins localized in the secretory pathway operate to activate alkaline phosphatases in vertebrate cells.2005
- Author(s)
  Suzuki, T., Ishihara, K., Migaki, H., Nagao, M., Yamaguchi-Iwai, Y., Kambe, T.
- Journal Title
  
  J. Biol. Chem. 280
  
  Pages: 30956-30962
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] and assay of an oxidation-specific ubiquitin ligase, HOIL-1.2005
- Author(s)
  Iwai, K., Ishikawa, H., Kirisako, T., Identification, expression
- Journal Title
  
  Methods Enzymol. 398
  
  Pages: 256-271
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.2005
- Author(s)
  Measday, V., Baetz, K., Guzzo, J., Yuen, K., Kwok, T., Sheikh, B., Ding, H., Ueta, R., Hoac, T., Cheng, B., Pot, I., Tong, A., Yamaguchi-Iwai, Y., Boone, C., Hieter, P., Andrews.B.
- Journal Title
  
  Proc. Natl. Acad. Sci. USA 102
  
  Pages: 13956-13961
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1.2005
- Author(s)
  Iwai, K., Ishikawa, H., Kirisako, T.
- Journal Title
  
  Methods Enzymol. 398
  
  Pages: 256-271
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Involvement of heme regulatory motif in heme-mediated ubiquitination and degradation of IRP22005
- Author(s)
  Ishikawa, H., Kato, M., Hori, H., Ishmori, K., Kirisako, T., Tokunaga, F.and Iwai, K.
- Journal Title
  
  Molecular Cell 19
  
  Pages: 171-181
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Identification, expression, and assay of an oxidation-specific ubiquitin ligase, HOIL-1.2005
- Author(s)
  Iwai, K., Ishikawa, H., Kirisako, T.
- Journal Title
  
  Methods Enzymol 398
  
  Pages: 256-271
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Systematic yeast synthetic lethal and synthetic dosage lethal screens identify genes required for chromosome segregation.2005
- Author(s)
  Measday, V., Baetz, K., Guzzo, J., Yuen, K., Kwok, T., Sheikh, B., Ding, H., Ueta, R., Hoac, T., Cheng, B., Pot, I., Tong, A., Yamaguchi-Iwai, Y., Boone, C., Hieter, P., Andrews, B.
- Journal Title
  
  Proc.Natl.Acad.Sci. 102
  
  Pages: 13956-13961
- Data Source
  KAKENHI-PROJECT-17054019
[Journal Article] Structural basis of sugar-recognizing ubiquitin ligase.2004
- Author(s)
  Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K.
- Journal Title
  
  Nat.Struct.Mol.Biol. 11
  
  Pages: 365-370
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Structural basis of sugar-recognizing ubiquitin ligase.2004
- Author(s)
  Mizushima, T., Hiro, T., Yoshida, Y., Lee, S. J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K., Tsukihara, T., Tanaka, K.
- Journal Title
  
  Nature Structural & Molecular Biology 11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Structural basis of sugar-recognizing ubiquitin ligase2004
- Author(s)
  Mizushima, T., Hirao, T., Yoshida, Y., Lee, S.J., Chiba, T., Iwai, K., Yamaguchi, Y., Kato, K, Tsukihara, T.and Tallaka, K.
- Journal Title
  
  Nature Structural & Molecular Biology 11
  
  Pages: 365-370
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains.2004
- Author(s)
  Tenno, T., Fujiwara, K., Tochio, H., Iwai, K., Morita, E.H., Hayashi, H., Murata, S., Hiroaki, H., Sato, M., Tanaka, K., Shirakawa, M.
- Journal Title
  
  Genes Cells. 9
  
  Pages: 865-875
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Overview of mammalian zinc transporter.2004
- Author(s)
  Kambe, T., Yamaguchi-Iwai, Y., Sasaki R., Nagao, M.
- Journal Title
  
  Cell. Mol. Life Sci. 61
  
  Pages: 49-68
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] The Ubiquitin System : From Basic Mechanisms to the Patient Bed.2004
- Author(s)
  Ciechanover, A, Iwai, K.
- Journal Title
  
  IUBMB Life 56
  
  Pages: 193-201
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] 分子遺伝学アプローチによる鉄代謝機構研究の進展2004
- Author(s)
  岩井裕子
- Journal Title
  
  生化学 76
  
  Pages: 441-444
- NAID
  10013052821
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Overview of mammalian zinc transporter.2004
- Author(s)
  Kambe, T., Yamaguchi-Iwai, Y., Sasaki R., Nagao, M.
- Journal Title
  
  Cell.Mol.Life Sci. 61
  
  Pages: 49-68
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Identification of the ubiquitin-protein ligase that recognizes oxidized IRP22003
- Author(s)
  Yamanaka, K., Ishikawa, H., Megumi, Y., Tokunaga, F., Kanie, M., Rouault, T. A., Morishima, I., Minato, N., Ishimori, K., Iwai K.
- Journal Title
  
  Nature Cell Biology 5
  
  Pages: 336-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Identification of the Ubiquitin-protein Ligase that Recognizes Oxidized IRP22003
- Author(s)
  Koji Yamanaka, Hartuto Ishikawa, Yuzuru Megumi, Fuminori Tokunaga, Masato Kanie, Tracy A.Rouault, Isao Morishima, Nagahiro Minato, Koichiro Ishimori, Kazuhiro Iwai
- Journal Title
  
  Nat.Cell Biol. 5
  
  Pages: 336-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains.2003
- Author(s)
  Yukiko Yoshida, Fuminori Tokunaga, Tomoki Chiba, Kazuhiro Iwai, Keiji Tanaka, Tadashi Tai
- Journal Title
  
  J.Biol.Chem. 278
  
  Pages: 43877-43884
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590279
[Journal Article] Identification of the ubiquitin-protein ligase that recognizes oxidized IRP22003
- Author(s)
  Yamanaka, K., Ishikawa, H., Megmni, Y., Tokunaga, F., Kanie, M., Rouault, T.A., Morishima L, Minato, N., Ishimori, K., Iwai, K.
- Journal Title
  
  Nature Cell Biology 5
  
  Pages: 336-340
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] E3 ubiquitin-ligase that recognises sugar chains2002
- Author(s)
  Yosbida, Y., Chiba, T., Tokunaga, F., Kawasaki, H., Iwai K, Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K.and Tai, T.
- Journal Title
  
  Nature 418
  
  Pages: 438-442
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] E3 ubiquitin-ligase that recognises sugar chains2002
- Author(s)
  Yoshida, Y., Chiba, T., Tokunaga, F., Kawasaki, H., Iwai K., Suzuki, T., Ito, Y., Matsuoka, K., Yoshida, M., Tanaka, K., Tai, T.
- Journal Title
  
  Nature. 418
  
  Pages: 438-442
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14GS0322
[Journal Article] Sequence similarlity and functional relationship among eukaryotic ZIP and CDF transporters
- Author(s)
  Kambe, K., Suzuki, T., Nagao, M., Yamaguchi-Iwai, Y.
- Journal Title
  
  Genomics Proteomics and Bioinformatics (in press)
- Data Source
  KAKENHI-PROJECT-17054019
[Journal Article] Mechanism Underlying the Iron-Dependent Nuclear Export of the Iron-Responsive Transcription Factor Aftlp in Saccharomyces Cervisiae
- Author(s)
  Fujiwara N., Ueta R., Iwai K., Yamaguchi-Iwai Y.
- Journal Title
  
  Molecular Biology of the Cell (In revision)
- Data Source
  KAKENHI-PROJECT-18055016
[Journal Article] Mechanism Underlying the Iron-Dependent Nuclear Export of the Iron-Responsive Transcription Factor Aftlp in Saccharomyces Cervisiae
- Author(s)
  Ueta R., Fujiwara N., Iwai K., Yamaguchi-Iwai Y.
- Journal Title
  
  Molecular Biology of the Cell (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Sequence similarlity and functional relationship among eukaryotic ZIP and CDF transporters
- Author(s)
  Kambe, K., Suzuki, T., Nagao, M., Yamaguchi-Iwai, Y.
- Journal Title
  
  Genomics Proteomics and Bioinformatics (in press)
- Data Source
  KAKENHI-PROJECT-16370061
[Journal Article] Mechanism Underlying the Iron-Dependent Nuclear Export of the Iron-Responsive Transcription Factor Aftlp in Saccharomyces Cervisiae
- Author(s)
  Ueta R., Fujiwara N., Iwai K., Yamaguchi-Iwai Y.
- Journal Title
  
  Molecular Biology of the Cell (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370061
[Patent] 特許2012
- Inventor(s)
  岩井一宏
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Number
  2011-525944
- Filing Date
  2012-02-20
- Data Source
  KAKENHI-PROJECT-22249008
[Patent] 新規なユビキチンリガーゼおよびその利用2010
- Inventor(s)
  岩井一宏
- Industrial Property Rights Holder
  大阪大学
- Filing Date
  2010-08-06
- Overseas
- Data Source
  KAKENHI-PLANNED-18076004
[Patent] 新規なユビキチンリガーゼおよびその利用2010
- Inventor(s)
  岩井一宏
- Industrial Property Rights Holder
  大阪大学
- Filing Date
  2010-08-06
- Overseas
- Data Source
  KAKENHI-PROJECT-22249008
[Patent] 新規なユビキチンリガーゼおよびその利用2010
- Inventor(s)
  岩井一宏
- Industrial Property Rights Holder
  大阪大学
- Filing Date
  2010-08-06
- Overseas
- Data Source
  KAKENHI-ORGANIZER-18076008
[Patent] 新規なユビキチンリガーゼ及びその利用2010
- Inventor(s)
  岩井一宏
- Industrial Property Rights Holder
  大阪大学
- Filing Date
  2010-08-06
- Data Source
  KAKENHI-PLANNED-18076004
[Patent] 新規なユビキチンリガーゼ及びその利用2009
- Inventor(s)
  岩井一宏
- Industrial Property Rights Holder
  大阪大学
- Industrial Property Number
  2009-184878
- Filing Date
  2009-08-07
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] 直鎖状ユビキチン鎖：免疫疾患、がんに寄与する新規シグナル伝達系2020
- Author(s)
  岩井　一宏
- Organizer
  第70回日本薬学会関西支部大会　特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] From Bench to Bedsides:ユビキチン研究の進展～COVID-19創薬の可能性も含めて～2020
- Author(s)
  岩井　一宏
- Organizer
  第68回日本職業災害医学会学術大会　特別講演
- Invited
- Data Source
  KAKENHI-PLANNED-18H05499
[Presentation] LUBACの2つのユビキチンリガーゼ活性による免疫シグナル制御2020
- Author(s)
  岩井　一宏
- Organizer
  第45回医用マススペクトル学会年会　シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] LUBACの2つのユビキチンリガーゼ活性による免疫シグナル制御2020
- Author(s)
  岩井　一宏
- Organizer
  第45回医用マススペクトル学会年会　シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05499
[Presentation] 直鎖状ユビキチン鎖：免疫疾患、がんに寄与する新規シグナル伝達系2020
- Author(s)
  岩井　一宏
- Organizer
  第70回日本薬学会関西支部大会　特別講演
- Invited
- Data Source
  KAKENHI-PLANNED-18H05499
[Presentation] From Bench to Bedsides:ユビキチン研究の進展～COVID-19創薬の可能性も含めて～2020
- Author(s)
  岩井　一宏
- Organizer
  第68回日本職業災害医学会学術大会　特別講演
- Invited
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] ユビキチン研究の現況と創薬への応用2019
- Author(s)
  岩井一宏
- Organizer
  第21回日本応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] がん、免疫疾患を惹起するユビキチン・シグナリング系：ケミカルバイオロジーを用いた介入の可能性2019
- Author(s)
  岩井　一宏
- Organizer
  日本生化学会　近畿地方会
- Invited
- Data Source
  KAKENHI-PLANNED-18H05499
[Presentation] ユビキチン研究の現況と創薬への応用2019
- Author(s)
  岩井　一宏
- Organizer
  第21回日本応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] がん、免疫疾患を惹起するユビキチン・シグナリング系：ケミカルバイオロジーを用いた介入の可能性2019
- Author(s)
  岩井　一宏
- Organizer
  日本生化学会　近畿地方会
- Invited
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] がん、免疫疾患を惹起するユビキチン・シグナリング系：ケミカルバイオロジーを用いた介入の可能性2019
- Author(s)
  岩井一宏
- Organizer
  第66回日本生化学会近畿支部例会
- Invited
- Data Source
  KAKENHI-ORGANIZER-18H05497
[Presentation] ユビキチン研究の現況と創薬への応用2019
- Author(s)
  岩井　一宏
- Organizer
  第21回日本応用薬理シンポジウム
- Invited
- Data Source
  KAKENHI-PLANNED-18H05499
[Presentation] Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis2017
- Author(s)
  Iwai, K.
- Organizer
  2017 International protein metabolism and disease conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] Ubiquitin in signaling: a tale of atypical linear ubiquitin chains2017
- Author(s)
  Iwai, K.
- Organizer
  hanghaiTech Life Science Seminar Series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H06174
[Presentation] Ubiquitin in signaling: a tale of atypical linear ubiquitin chains2017
- Author(s)
  Iwai, K.
- Organizer
  hanghaiTech Life Science Seminar Series
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-17H06078
[Presentation] Linear ubiquitin chains: NF-kappaB activation, cell death, and oncogenesis2017
- Author(s)
  Iwai, K.
- Organizer
  2017 International protein metabolism and disease conference
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-WRAPUP-17H06078
[Presentation] Pathophysiology of the atypical linear ubiquitin chain2016
- Author(s)
  Iwai, K
- Organizer
  Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond
- Place of Presentation
  Kyoto Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Pathophysiology of the atypical linear ubiquitin chain2016
- Author(s)
  Iwai, K
- Organizer
  Diverse functions of Ubiquitin : Degradation, Signaling, and Beyond
- Place of Presentation
  Kyoto Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death.2015
- Author(s)
  Shimizu, S., Fujita, H., Sasaki, Y., and Iwai, K.
- Organizer
  EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases”
- Place of Presentation
  Cavtat, Croatia
- Year and Date
  2015-09-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.2015
- Author(s)
  Iwai, K.
- Organizer
  1st SPS International Symposium Xiamen University
- Place of Presentation
  Xiamen, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.2015
- Author(s)
  Iwai, K.
- Organizer
  International Symposium on Ubiquitin and Diseases.
- Place of Presentation
  Zhangjiajie, China
- Year and Date
  2015-06-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Patho-physiological functions of a new type of ubiquitin modification, linear ubiquitination.2015
- Author(s)
  Iwai, K.
- Organizer
  LLS Lecture, Northwestern University, Feinberg School of Medicine.
- Place of Presentation
  Chicago, IL, USA.
- Year and Date
  2015-10-13
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Differential involvement of subunits of LUBAC ubiquitin ligase in signalling and cell death.2015
- Author(s)
  Shimizu, S., Fujita, H., Sasaki, Y., and Iwai, K.
- Organizer
  EMBO Conference “Ubiquitin and ubiquitin-like modifiers: From molecular mechanisms to human diseases”
- Place of Presentation
  Cavtat, Croatia
- Year and Date
  2015-09-18
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear ubiquitin chains: a new regulator of NF-κB activation and cell death signaling.2015
- Author(s)
  Iwai, K.
- Organizer
  1st SPS International Symposium Xiamen University
- Place of Presentation
  Xiamen, China
- Year and Date
  2015-06-13
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin.2015
- Author(s)
  Sakamoto, H., Egashira, S., Okabe, T., Nagano, T., and Iwai, K.
- Organizer
  Cold Spring Harbor Laboratory meeting “The Ubiquitin Family”
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear ubiquitin chains: NF-kappaB activation, cell death, and cancer.2015
- Author(s)
  Iwai, K.
- Organizer
  International Symposium on Ubiquitin and Diseases.
- Place of Presentation
  Zhangjiajie, China
- Year and Date
  2015-06-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear ubiquitin chains: a new regulator of NF-kappaB activation and cell death signaling.2015
- Author(s)
  Iwai, K.
- Organizer
  1st SPS International Symposium Xiamen University
- Place of Presentation
  Xiamen, China
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] LUBAC-mediated linear ubiquitination by a virulence factor of Aspergillus, gliotoxin.2015
- Author(s)
  Sakamoto, H., Egashira, S., Okabe, T., Nagano, T., and Iwai, K.
- Organizer
  Cold Spring Harbor Laboratory meeting “The Ubiquitin Family”
- Place of Presentation
  Cold Spring Harbor, NY, USA
- Year and Date
  2015-04-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Molecular mechanism and regulation of linear chain-mediated NF-κB activation.2014
- Author(s)
  Fujita, H., Takiuchi, T., and Iwai, K.
- Organizer
  Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis”
- Place of Presentation
  Suzhou, China
- Year and Date
  2014-06-16
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.2014
- Author(s)
  Iwai, K.
- Organizer
  1st International Symposium for New Aspects of the Ubiquitin Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-11-10
- Invited
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.2014
- Author(s)
  Iwai, K.
- Organizer
  1st International Symposium for New Aspects of the Ubiquitin Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-11-10
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Phenotypical difference between mice lacking subunits of LUBAC ubiquitin ligase.2014
- Author(s)
  Iwai, K.
- Organizer
  1st International Symposium for New Aspects of the Ubiquitin Research
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2014-11-10
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear Polyubiquitination: a Crucial Regulator of NF-κB Activation.2014
- Author(s)
  Iwai, K.
- Organizer
  THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development.
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2014-06-14
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Induction of expression of linear ubiquitin chain generating LUBAC ligase and amelioration of dermatitis in cpdm mice by interferons.2014
- Author(s)
  Tamiya, H. and Iwai, K.
- Organizer
  he EMBO conference “Ubiquitin & ubiquitin-like proteins: At the crossroads from chromatin to protein”
- Place of Presentation
  Buenos Aires, Argentina
- Year and Date
  2014-10-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Increased redox-active iron induces mitochondrial damage that recruits Parkin.2014
- Author(s)
  Iwai, K. and Takeda, Y.
- Organizer
  The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment”
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Mechanism underlying linear ubiquitin-mediated NF-κB activation.2014
- Author(s)
  Iwai, K.
- Organizer
  Benzon Symposium Nuclear regulation by ubiquitin
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-18
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Linear ubiquitination : a new regulator of NF-κB and cell death signaling.2014
- Author(s)
  Iwai, K.
- Organizer
  2014 International Conference on Protein Metabolism & Diseases
- Place of Presentation
  Yangyang, Korea
- Year and Date
  2014-07-09
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Increased redox-active iron induces mitochondrial damage that recruits Parkin.2014
- Author(s)
  Iwai, K.
- Organizer
  The 17th Biennial Meeting of Society for Free Radical Research International. Symposium “Redox-Active Iron in Disease Pathology and Treatment”
- Place of Presentation
  Kyoto, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Linear polyubiquitination : a new regulator of NF-B activation2013
- Author(s)
  Iwai, K
- Organizer
  The 38^<th> FEBS congress symposium"Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease : proteolysis, autophagy and apoptosis"
- Place of Presentation
  St. Petersburg, Russia (Invited)
- Year and Date
  2013-07-07
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation2013
- Author(s)
  Iwai, K.
- Organizer
  The 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
- Place of Presentation
  Sapporo, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Linear polyubiquitination : a new regulator of NF-κB activation2013
- Author(s)
  Iwai, K
- Organizer
  The 35^<th> Naito Conference"The Ubiquitin-Proteasome System : From Basic Mechanisms to Pathophysiological Roles"
- Place of Presentation
  Sapporo, Japan (Invited)
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-κB activation in B cells.2013
- Author(s)
  Sasaki, Y., Fujita, H., and Iwai, K.
- Organizer
  The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”
- Place of Presentation
  Riva del Garda, Italy.
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.2013
- Author(s)
  Iwai, K.
- Organizer
  he 38th FEBS congress
- Place of Presentation
  St. Petersburg, Russia
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-κB activation in B cells.2013
- Author(s)
  Sasaki, Y., Fujita, H., and Iwai, K.
- Organizer
  The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”
- Place of Presentation
  Riva del Garda, Italy.
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation2013
- Author(s)
  Iwai, K.
- Organizer
  The 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
- Place of Presentation
  Sapporo, Japan
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.2013
- Author(s)
  Iwai, K.
- Organizer
  he 38th FEBS congress
- Place of Presentation
  St. Petersburg, Russia
- Invited
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Mechanism underlying generation of linear polyubiquitin chains2012
- Author(s)
  Iwai, K
- Organizer
  4th Annual Ubiquitin Drug Discovery & Diagnostics Conference
- Place of Presentation
  Four Seasons Hotel, Philadelphia, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination : A crucial regulator of NF-kB signaling2012
- Author(s)
  Iwai, K.
- Organizer
  The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems
- Place of Presentation
  Magdeburg, Germany
- Year and Date
  2012-11-22
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Linear polyubiquitination : A crucial regulator of NF-B signaling2012
- Author(s)
  Iwai, K
- Organizer
  The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems"
- Place of Presentation
  Magdeburg, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination : A crucial regulator of NF-kB signaling.2012
- Author(s)
  Iwai, K.
- Organizer
  The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“
- Place of Presentation
  Magdeburg, Germany
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination: a regulator of NF-κB activation.2012
- Author(s)
  Iwai, K.
- Organizer
  2012 FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation”
- Place of Presentation
  Vermont, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24659136
[Presentation] Linear polyubiquitination : A crucial regulator of NF-kB signaling.2012
- Author(s)
  Iwai, K.
- Organizer
  The 3rd International Symposium "Signaling and Regulation in the Immune and Nervous Systems“
- Place of Presentation
  Magdeburg, Germany
- Year and Date
  2012-11-22
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear polyubiquitination : a regulator of NF-B activation2012
- Author(s)
  Iwai, K
- Organizer
  2012 FASEB Summer Research Conferences"Ubiquitin & Cellular Regulation"
- Place of Presentation
  Saxtons River, Vermont, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Mechanism underlying generation of linear polyubiquitin chains.2012
- Author(s)
  Iwai, K.
- Organizer
  4th Annual Ubiquitin Drug Discovery & Diagnostics Conference 2012
- Place of Presentation
  Philadelphia, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Mechanism underlying generation of linear polyubiquitin chains2012
- Author(s)
  Iwai, K
- Organizer
  4th Annual Ubiquitin Drug Discovery Diagnostics Conference 2012
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-07-23
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Linear polyubiquitination: a regulator of NF-κB activation.2012
- Author(s)
  Iwai, K.
- Organizer
  2012 FASEB Summer Research Conferences “Ubiquitin & Cellular Regulation”
- Place of Presentation
  Vermont, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination : A crucial regulator of NF-B signaling2012
- Author(s)
  Iwai, K., Fujita, H., Nakahara, M., Sano, S. and Tokunaga. F
- Organizer
  Keystone Symposium"NF-B signaling and Biology : From Bench to Bedside"and"Ubiquitin Signaling"
- Place of Presentation
  Whistler, Canada
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination : A crucial regulator of NF-B signalling2012
- Author(s)
  Fujita, H., Sasaki, Y., Nakahara, M. Iwai, K
- Organizer
  A crucial regulator of NF-B signalling ZOMESVII conference
- Place of Presentation
  Munich Germany
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Mechanism underlying generation of linear polyubiquitin chains.2012
- Author(s)
  Iwai, K.
- Organizer
  4th Annual Ubiquitin Drug Discovery Diagnostics Conference 2012
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2012-07-23
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear polyubiquitination : A new regulator of NF-B activation2011
- Author(s)
  Iwai, K
- Organizer
  The EMBO Conference"Ubiquitin and Ubiquitin-like Modifiers : From functional modules to system biology"
- Place of Presentation
  Cavtat, Croatia
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] 関節リウマチにおける NFκB 活性化経路の新規ユビキチンリガーゼ LUBAC の発現2011
- Author(s)
  冨田哲也、森口悠、椚座康夫、徳永文稔、岩井一宏、吉川秀樹
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22591685
[Presentation] Linear polyubiquitination : A new regulator of NF-κB activation2011
- Author(s)
  Iwai, K.
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers From functional modules to system biology"
- Place of Presentation
  Cavtat(クロアチア)(招待講演)
- Year and Date
  2011-09-25
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear Polyubiquitination : A Newly Identified Regulator of NF-κB Signaling.2010
- Author(s)
  Iwai, K.
- Organizer
  BIOLOGY OF THE UBIQUITIN AND THE UBIQUITIN-LIKE SYSTEMS Research Conference of the Institute for Advanced Studies, the Israel Science Foundation.(Invited)
- Place of Presentation
  Jerusalem, Israel.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling.2010
- Author(s)
  Iwai, K.
- Organizer
  Banbury Center meetings,"SIGNALING THROUGH UBIQUITIN(Invited)
- Place of Presentation
  The Banbury Center, Cold Spring Harbor Laboratory, New York, USA.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] 新規直鎖状ポリユビキチン化によるNF-κB活性化制御と疾患(ワークショップ)2010
- Author(s)
  徳永文稔、岩井一宏
- Organizer
  VMB2010
- Place of Presentation
  神戸
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling.2010
- Author(s)
  Iwai, K.
- Organizer
  FASEB Summer Research Conferences "Ubiquitin and Cellular Regulation"
- Place of Presentation
  Saxtons River, Vermont, USA(招待講演)
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear Polyubiquitination : A Newly Identified Regulator of NF-κB Signaling2010
- Author(s)
  Iwai, K.
- Organizer
  Biology of the Ubiquitin and the Ubiquitin-Like Systems
- Place of Presentation
  イスラエル(エルサレム市)
- Year and Date
  2010-03-15
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Dissection of intracellular heme transport mechanism using a baker's yeast, Saccharomyces cerevisiae2010
- Author(s)
  Ueta, R. and Iwai, K
- Organizer
  JSH International Symposium 2010 in Akita, Seven Wonders of Erythropoiesis
- Place of Presentation
  Akita, Japan
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling.2010
- Author(s)
  Iwai, K.
- Organizer
  2010 FASEB Summer Research Conferences "Ubiquitin and Cellular Regulation"(Invited)
- Place of Presentation
  Saxtons River, Vermont, USA.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear polyubiquitination : a new regulator of NF-B signaling. Banbury Center meetings2010
- Author(s)
  Iwai, K
- Organizer
  SIGNALING THROUGH UBIQUITIN
- Place of Presentation
  The Banbury Center, Cold Spring Harbor Laboratory, New York, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Linear polyubiquitination : a new regulator of NF-B signaling2010
- Author(s)
  Iwai, K
- Organizer
  2010 FASEB Summer Research Conferences"Ubiquitin and Cellular Regulation"
- Place of Presentation
  Saxtons River, Vermont, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] 直鎖状ポリユビキチン鎖生成ユビキチンリガーゼ(LUBAC)の新規サブユニットの同定2010
- Author(s)
  徳永文稔、岩井一宏
- Organizer
  第2回シグナルネットワーク研究会
- Place of Presentation
  大阪
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Linear polyubiquitination : A newly identified regulator of NF-κB signaling.2010
- Author(s)
  Iwai, K., Sakata, S.-I., Nakagawa, T., Tokunaga, F.
- Organizer
  Keystone Symposium "NF-κB in Inflammation and Disease"
- Place of Presentation
  Santa Fe, New Mexico, USA.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling.2010
- Author(s)
  Kazuhiro Iwai.
- Organizer
  Banbury Center meetings, Signaling through ubiquitin.The Banbury Center, Cold Spring Harbor Laboratory
- Place of Presentation
  New York, USA.
- Data Source
  KAKENHI-ORGANIZER-18076008
[Presentation] Linear polyubiquitination : a new regulator of NF-κB signaling2010
- Author(s)
  Iwai, K.
- Organizer
  FASEB Summer Research Conferences "Ubiquitin and Cellular Regulation"
- Place of Presentation
  Saxtons River, Vermont, USA(招待講演)
- Data Source
  KAKENHI-PROJECT-22249008
[Presentation] Involvement of linear polyubiquitination of NEMO in NF-κB activation2009
- Author(s)
  Tokunaga, F., Sakata, S.-I., Nakagawa, T., Iwai, K.
- Organizer
  Cold Spring Harbor Laboratory meeting "The Ubiquitin Family"
- Place of Presentation
  Cold Spring Harbor, NY, USA.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] NEM2分子以上の直鎖状ポリユビキチン化はNF-κB活性化を導く2009
- Author(s)
  徳永文稔、亀井希代子、岩井一宏
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Physiological function of linear polyubiquitin chain2009
- Author(s)
  Iwai K.
- Organizer
  Keystone Symposium "The Many Faces of Ubiquitin"
- Place of Presentation
  Copper Mountain Resort, CO, LISA
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Physiological function of linear polyubiquitin chain2009
- Author(s)
  岩井一宏(Kazuhiro Iwai)
- Organizer
  Keystone Symposium"The Many Faces of Ubiquitin"
- Place of Presentation
  Copper Mountahi Resort, 米国コロラド州
- Year and Date
  2009-01-13
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] polyubiquitination : A newly identified regulator of NF-κB signaling.2009
- Author(s)
  Iwai, K., Tokunaga, F.Linear
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
- Place of Presentation
  Riva Del Garda, Italy.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] 直鎖状ポリユビキチン化:NF-κB活性化を導く新たなポリユビキチン鎖(ワークショップ)2009
- Author(s)
  徳永文稔、中川朋子、坂田真一、岩井一宏
- Organizer
  第32回日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] 直鎖状ポリユビキチン化:NF-κB活性化に必須な新たなユビキチン修飾系(シンポジウム)2009
- Author(s)
  徳永文稔、岩井一宏
- Organizer
  第1回シグナルネットワーク研究会
- Place of Presentation
  東京
- Year and Date
  2009-05-29
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Physiological Function of Linear Polyubiquitin Chain.2009
- Author(s)
  Iwai, K.
- Organizer
  Keystone Symposium "The Many Faces of Ubiquitin"(Invited)
- Place of Presentation
  Copper Mountain Resort, CO, USA
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] The COP9/Signalosome increases the efficiency of pVHL-containing ubiquitin ligase.mediated HIF-α ubiquitination.2008
- Author(s)
  Miyauchi, Y., Kato, M., Tokunaga, F., Iwai, K.
- Organizer
  ZOMESV : The Fifth International Symposium on the COP9 signalosome, Proteasome and eIF3 : At the interface between signaling and proteolysis(Invited)
- Place of Presentation
  Yokohama, Japan.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] LUBACユビキチンリガーゼによるNEMOの直鎖状ポリユビキチン化修飾とNF-κB活性化の分子機構2008
- Author(s)
  徳永文稔、坂田真一、佐伯泰、亀井希代子、中川朋子、山岡昇司、山本雅裕、審良静男、高尾敏文、田中啓二、岩井一宏
- Organizer
  BMB2008
- Place of Presentation
  神戸
- Year and Date
  2008-12-11
- Data Source
  KAKENHI-PROJECT-20390097
[Presentation] Linear ubiquitination of NEMO triggers NF-kB activation.2007
- Author(s)
  Tokunaga, F., Sakata, S.-I., Kirisako, T., Nakagawa, T., Murata, S.Tanaka, K.Iwai, K.
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
- Place of Presentation
  Riva Del Garda, Italy.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear ubiquitination of NEMO triggers NF-KB activation2007
- Author(s)
  Tokunaga, F., Sakata, S.-I., Kirisako, T., Nakagawa, T., Murata, S. Tanaka, K. and Iwai, K.
- Organizer
  The EMBO Conference "Ubiquitin and Ubiquitin-like Modifiers in Cellular Regulation"
- Place of Presentation
  Riva Del Garda Italy
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Identification of a ligase complex polymerizing linear polyubiquitin chains and its physiological role.2006
- Author(s)
  Kirisako, T., Tokunaga, F., Nakamura, M., Iwai, K.
- Organizer
  The Fourth NIBB-EMBL Symposium,(Invited)
- Place of Presentation
  Okazaki, Japan.
- Data Source
  KAKENHI-PLANNED-18076004
[Presentation] Linear ubiquitination : a new regulator of NF-κB and cell death signaling.
- Author(s)
  Iwai, K.
- Organizer
  2014 International Conference on Protein Metabolism & Diseases
- Place of Presentation
  Yangyang, Korea
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Linear Polyubiquitination: a Crucial Regulator of NF-κB Activation.
- Author(s)
  Iwai, K.
- Organizer
  THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development.
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2014-06-14 – 2014-06-17
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.
- Author(s)
  Iwai, K.
- Organizer
  The 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2013-07-09 – 2013-07-12
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-κB activation in B cells
- Author(s)
  Sasaki, Y., Fujita, H., and Iwai, K.
- Organizer
  The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2013-10-01 – 2013-10-05
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.
- Author(s)
  Iwai, K.
- Organizer
  The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis”
- Place of Presentation
  St. Petersburg, Russia
- Year and Date
  2013-07-06 – 2013-07-12
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Differential requirement of LUBAC-mediated linear polyubiquitination in CD40- or BCR-mediated canonical NF-κB activation in B cells
- Author(s)
  Sasaki, Y., Fujita, H., and Iwai, K.
- Organizer
  The EMBO Conference “Ubiquitin and Ubiquitin-like Proteins: From structure to function”
- Place of Presentation
  Riva del Garda, Italy
- Year and Date
  2013-10-01 – 2013-10-05
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Molecular mechanism and regulation of linear chain-mediated NF-κB activation.
- Author(s)
  Fujita, H., Takiuchi, T., and Iwai, K.
- Organizer
  Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis”
- Place of Presentation
  Suzhou, China
- Year and Date
  2014-06-16 – 2014-06-20
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Mechanism underlying linear ubiquitin-mediated NF-κB activation.
- Author(s)
  Iwai, K.
- Organizer
  Benzon Symposium Nuclear regulation by ubiquitin
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-18 – 2014-08-21
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Linear ubiquitination : a new regulator of NF-κB and cell death signaling.
- Author(s)
  Iwai, K.
- Organizer
  2014 International Conference on Protein Metabolism & Diseases
- Place of Presentation
  Yangyang, Korea
- Year and Date
  2014-07-09 – 2014-07-11
- Invited
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear Polyubiquitination: a Crucial Regulator of NF-κB Activation.
- Author(s)
  Iwai, K.
- Organizer
  THE UEHARA MEMORIAL FOUNDATION SYMPOSIUM 2014, Innovative Medicine : Basic Research and Development.
- Place of Presentation
  Tokyo, Japan
- Year and Date
  2014-06-14 – 2014-06-17
- Invited
- Data Source
  KAKENHI-ORGANIZER-24112001
[Presentation] Mechanism underlying linear ubiquitin-mediated NF-κB activation.
- Author(s)
  Iwai, K.
- Organizer
  Benzon Symposium Nuclear regulation by ubiquitin
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-18 – 2014-08-21
- Data Source
  KAKENHI-PLANNED-24112002
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.
- Author(s)
  Iwai, K.
- Organizer
  The 35th Naito Conference “The Ubiquitin-Proteasome System: From Basic Mechanisms to Pathophysiological Roles”
- Place of Presentation
  Sapporo, Japan
- Year and Date
  2013-07-09 – 2013-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Linear polyubiquitination: a new regulator of NF-κB activation.
- Author(s)
  Iwai, K.
- Organizer
  The 38th FEBS congress symposium “Regulation of biological processes by ubiquitin and ubiquitin-like proteins in health and disease: proteolysis, autophagy and apoptosis”
- Place of Presentation
  St. Petersburg, Russia
- Year and Date
  2013-07-06 – 2013-07-12
- Invited
- Data Source
  KAKENHI-PROJECT-25253019
[Presentation] Molecular mechanism and regulation of linear chain-mediated NF-κB activation.
- Author(s)
  Fujita, H., Takiuchi, T., and Iwai, K.
- Organizer
  Cold Spring Harbor Asia Conference “ Protein Modifications & Homeostasis”
- Place of Presentation
  Suzhou, China
- Year and Date
  2014-06-16 – 2014-06-20
- Invited
- Data Source
  KAKENHI-PLANNED-24112002

1. MINATO Nagahiro (40137716)

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2. TOKUNAGA Fuminori (00212069)

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54. TAKAGI Kenji

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56. SAITOH Tatsuya

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57. KOBAYASHI Shouhei

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58. HASHIMOTO Nobuyuki

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Iwai Kazuhiro 岩井 一宏

IWAI Kazuhiro 岩井 一宏

Research Projects

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Co-Researchers

Involvement of linear ubiquitination in regulation of cancer and immunityPrincipal Investigator

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Integrated analyses of LUBAC-mediated linear ubiquitinationPrincipal Investigator

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Functional regulation of ubiquitin chains using chemo-technologiesPrincipal Investigator

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ユビキチンネオバイオロジー：拡大するタンパク質制御システムPrincipal Investigator

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Extensive analyses of the LUBAC ubiquitin ligasePrincipal Investigator

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直鎖状ユビキチン鎖による生体制御機構の解析Principal Investigator

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Development of small molecules inhibiting linear ubiquitin-medaited NF-kappaB actviationPrincipal Investigator

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Patho-physiological function of the ubiquitin ligase that generates linear ubiquitin chains (LUBAC)Principal Investigator

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New aspect of the ubiquitin system : its enormous roles in protein regulationPrincipal Investigator

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Generation and function of linear ubiquitin chainsPrincipal Investigator

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Development of regulators of the LUBAC ubiquitin ligase that modulate NF-kappaB activationPrincipal Investigator

Iwai Kazuhiro 岩井一宏

IWAI Kazuhiro 岩井一宏