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Hattori Masakazu  服部 雅一

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HATTORI Masakazu  服部 雅一

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Researcher Number 40211479
Other IDs
Affiliation (Current) 2022: 京都大学, 医学研究科, 特定教授
Affiliation (based on the past Project Information) *help 2018 – 2019: 京都大学, 医学研究科, 特定教授
2017: 京都大学, 医学(系)研究科(研究院), 教授
2016: 京都大学, 医学研究科, 特定教授
2014 – 2015: 京都大学, 医学(系)研究科(研究院), 教授
2012: 北里大学, 理学部, 教授 … More
2011: 京都大学, 医学研究科, 教授
2010: 京都大学, 生命科学研究科, 准教授
2008 – 2010: Kitasato University, 理学部, 教授
2007: Kyoto University, 医学研究科, 准教授
2006: 京都大学, 生命科学研究所, 助教授
2003 – 2006: 京都大学, 生命科学研究科, 助教授
2003: 京都大学, 大学院・生命科学研究科, 助教授
1999 – 2001: Kyoto University, Graduate school of Biostudies, Dept. of Immunology and Cell Biology, Associate Professor, 生命科学研究科, 助教授
1997 – 1998: 京都大学, 医学研究科, 助教授
1997: 京都大学, 医学研究所, 助教授
1995 – 1996: Kyoto University, Faculty of Medicine Assistant, 医学研究科, 助手
1995: 京都大学, 医科研究科, 助手
1993 – 1995: 京都大学, 医学部, 助手
1989 – 1991: 北海道大学, 獣医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Immunology / Applied veterinary science / 基礎獣医学 / Basic veterinary science/Basic zootechnical science / Integrative animal science / Experimental pathology / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Veterinary medical science
Except Principal Investigator
Immunology … More / Biological Sciences / Applied veterinary science / Pathological medical chemistry / Urology / Biomedical engineering/Biological material science / Applied veterinary science Less
Keywords
Principal Investigator
Rap1 / SPA-1 / アナジー / Spa-1 / PD-1 / 核内蛋白 / 細胞周期 / プロセッシング / RaplGAP / 慢性骨髄性白血病 … More / 免疫監視 / 自己免疫疾患 / 免疫老化 / T細胞 / CD153 / 老化関連T細胞 / Ran GAP / 有糸分裂破綻 / 低分子G蛋白 / ロイシンジッパー / Rapl / ノックアウトマウス / T細胞機能不全 / Ras-ERKシグナル経路 / インターフェロン / SCIDマウス / 免疫学 / 白血病 / 老化 / アジュバント / オステオポンチン / 自己抗体 / RanGAP / Ran / cell cycle progression / GAP / 11q13.3 / bHLH / RAG2 / T cell / p27kip1 / B-CLL / CD3複合体 / CD153リバースシグナル / LGL / T細胞レセプタ- / 初期分化 / 1L3@1L2培養システム / 1L2依存性増殖 / 1L2レセプタ- / 細胞周期進行阻害 / 核内GTPase活性化蛋白 / PEST配列 / 第19染色体 / ガン抑制遺伝子 / Spa‐1 / PEST / ATP依存性プロテアーゼ / cell adhesion / C3G / 32D / integrin / インテグリン / AF6 / Eph / 骨髄微小環境 / SPA-1遺伝子破壊マウス / CD44陽性メモリーT細胞 / 白血病原性 / 骨髄性白血病 / 免疫監視機構 / B1a細胞 / OCaB / 癌 / CML / 白血病幹細胞 / BCR-Abl / C/EBPα / SATB1 / C / EBPα / 人工リンパ節 / 二次リンパ組織 / モノクローナル抗体 / インフルエンザウイルス / VEGF-A / 皮下移植 / 全身性エリテマトーデス / 死細胞処理 / 貪食 / 胚中心 / miR181a / 細胞周期進行 / インターロイキン2 / differential hybridization / RCC-1系 / リン酸化会合分子 / Rap1GAPホモログ / 翻訳時ホッピング / GAP活性 / 細胞増殖抑制 / nuclear protein / RCC-1 system / Interleukin-2 / differntial hybridization / 11g13.3 / リンパ球活性化 / GTPase活性化蛋白 / がん抑制遺伝子 / Hes1 / T / Notch / 胸腺 / HES1 / T細胞増殖制御 / ストローマ細胞 / Pre T細胞 / T細胞初期分化 / double negative / TCR非依存性増殖 / Hesl / Notchl / thymus / アポトーシス / アポプトーシス / P27kip1 / FAS / Rap1GAP / APC / LFA-1 / ICAM-1 / SPA- 1 / anergy / apoptosis / 自己免疫 / B1細胞 / OCAB / T細胞免疫不全 / 癌抑制遺伝子 / Ran1 / chronic myelogenous leukemia / Autoimmune disease / B1 cell / OcaB / DNAマイクロアレイ / 免疫不全 / ERK活性化 / T-cell immune deficiency / DNA microarray / Anergy / メモリーT細胞 / 免疫チェックポイント分子 / CD30L / CD30 / リバースシグナル / 加齢関連疾患 / TCRシグナル抑制 / CD163-CD30相互作用 / TCRシグナル阻害 / SLE … More
Except Principal Investigator
Rap1 / SPA-1 / 低分子G蛋白 / T細胞抗原レセプター / 4F2抗原 / small G protein / シグナル伝達 / GTPase活性化蛋白 / 胎生期抗原 / 胎児性抗原 / 胎生癌細胞 / 髄外造血 / 胎生造血 / 主要組織適合抗原 / 個体発生 / ユビキチン修飾 / 鉄イオン代謝 / プロテアソーム / 選択的蛋白分解 / γδ型T細胞 / ピロリン酸モノエステル / 非ペプチド抗原 / 自然免疫 / 前立腺癌 / 癌転移 / ゲノム / 原虫 / タイレリア / CD45 / Signal transduction / 核内蛋白 / ロイシンジッパー / がん抑制遺伝子 / 低分子量G蛋白 / バキュロウイルス / Ras / MHC抗原 / 造血系幹細胞 / T細胞レセプター / T細部亜群 / 酸化的修飾 / 酸化変化 / パターシ認識 / Spa-1 / 転移 / RAP1 / ECM / タイレリヤ / アビコンプレックス / 進化 / 細胞・組織工学 / 積層型高密度培養 / コラーゲン / コラーゲン細線維 / 血管再生 / PK15細胞 / バイオリアクター / ePTFE人工血管 / INTERGARD人工血管 / PLAシート / 人工血管 / CBD-cytokine / PEAC細胞 / HepG2細胞 / アルブミン / 免疫不全マウス / インタ-ロイキン2 / インタ-ロイキン2レセプタ- / トランスジェニックマウス / フォスファチジル・イノシト-ル / DNA結合蛋白 / リンフォカイン / 抗原レセプタ- / ハイブリド-マ / インタ-ロイキン3 / T細胞レセプタ- / アポプト-シス / フォスファチジルイノシト-ル結合蛋白 / 遺伝子再構成 / 細胞分化 / Interleukin 2 / IL 2 receptor / Transgenic mice / Phosphatidylinositol / DNA-binding protein / ヌードマウス / T細胞レパトア / 造血前駆細胞 / 骨髄 / インターロイキン3 / 胎児抗原 / 造血系前駆細胞 / T-cell Receptor / Major thstocompatibility Antigens / 4F2 antigen / Ontogeny / Fetal antigens / Extramedullary Hematopoiesis / Embryonal Carcinomas / Nude Mice / プロセッシング / PEST配列 / 第19染色体 / Ran binding / nuclear protein / processing / cell cycle progression / Ran / RCC-1 system / PEST / leucine zipper motif / リンパ球 / 細胞周期 / 細胞増殖 / 染色体マッピング / G蛋白活性化蛋白 / がん遺伝子 / サイトカイン / リンパ球活性化 / 細胞分裂 / 細胞同期 / lymphocutes / GTPase activating protein / cell cycle / baculovirus / proliferation / chusmosomal mapping / リコンビナントワクチン / 家禽 / アジュバント / マレック病 / ボツリヌス毒素 / 大腸菌発現ベクター / 真核生物発現ベクター / 鳥類インフルエンザウイルス / 高速液体クロマトグラフィー / コンポーネントワクチン / ニューカッスル病 / B抗原 / 細胞接着 / recombinant vaccine / chicken / adjuvant / Marek's disease virus / Botulinum toxin / prokaryotic expression vector / Newcastle disease virus / avian influenza virus / 細胞骨格 / 抗原レセプター / 免疫応答 / GTPase活性化蛋白(GAP) / アナ-ジ- / クローン増巾 / Small GTPases / Rap 1 / Cytaskleton / Antigen receptors / Immune response / GTPase activating protain(GAP) / 免疫系 / 非ペプチド性抗原 / T細胞受容体 / 病原性細菌 / 獲得性免疫 / がん細胞 / アルキルアミン / 結核菌 / 病原性大腸菌 / パターン抗原 / パターン認識 / immune system / γδ T cell / nonpeptide antigen / T cell receptor / pathogenic microbe / innate immunity / acquired_immunity / tumor cell / 免疫監視 / がん免疫 / 白血病 / 免疫抑制 / 免疫療法 / T細胞応答 / メモリーT細胞 / G蛋白 / T細胞 / 自己免疫病 / 自己抗体 / 造血幹細胞 / ループス腎炎 / レセプター編集 / 遺伝子ノックアウトマウス / 骨髄幹細胞異常症 / 免疫不全 / 抗DNA抗体 / アナジー / 癌抑制遺伝子 / 免疫記憶 / Immune surveillance / Tumor immunity / Leukemia / Immune suppression / Tumor immunotherapy / T cell responsiveness / Memory T cells / 獣医学 / 微生物 / 感染症 / ショットガン解析 / cDNA / Genome / Veterinary Medicine / Microbe / Infectious disease / Protozoa Less
  • Research Projects

    (41 results)
  • Research Products

    (42 results)
  • Co-Researchers

    (47 People)
  •  Study on a new ajuvant that induce memory T cells efficientlyPrincipal Investigator

    • Principal Investigator
      Hattori Masakazu
    • Project Period (FY)
      2018 – 2019
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 42:Veterinary medical science, animal science, and related fields
    • Research Institution
      Kyoto University
  •  Control of senescence-associated T cell-inductionPrincipal Investigator

    • Principal Investigator
      Hattori Masakazu
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Veterinary medical science
    • Research Institution
      Kyoto University
  •  Study on the mechanism(s) of immunosenescence and its application for vaccine development.Principal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Integrative animal science
    • Research Institution
      Kyoto University
  •  Generating artificial parenchymal and hollow organs fabricated with collagen fibrils,various cells, and cytokines using a bioreactor that we have developed

    • Principal Investigator
      ADACHI Eijiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biomedical engineering/Biological material science
    • Research Institution
      Kitasato University
  •  人工リンパ節技術を用いた新規アジュバントの開発と高機能型抗体の作製Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2010
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Applied veterinary science
    • Research Institution
      Kitasato University
  •  比較ゲノム解析によるタイレリア原虫病原性進化の解明

    • Principal Investigator
      杉本 千尋
    • Project Period (FY)
      2009 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      Hokkaido University
  •  がん・病原微生物によるT細胞機能抑制の分子メカニズム解明とその制御Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Basic veterinary science/Basic zootechnical science
    • Research Institution
      Kitasato University
  •  Research for a mechanism of prostate cancer metastasis through a SPA-1(Rap1GAP) signaling pathway.

    • Principal Investigator
      YOSHIMURA Kouji
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Urology
    • Research Institution
      Kyoto University
  •  smallGproteinを介した新たな癌転移機構の解明

    • Principal Investigator
      NAKAMURA Eijirou
    • Project Period (FY)
      2007
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Kyoto University
  •  骨髄性白血病発症モデルマウスを用いた免疫監視機構の総合的研究Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Raplシグナル遺伝子改変動物を用いた白血病発症に関わる免疫監視機構の総合的研究Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Genome analysis of Theileria orientalis and its functional genomics

    • Principal Investigator
      SUGIMOTO Chihiro
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      Hokkaido University
  •  Study on the second immune response by using SPA-1-deficient mice.Principal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Applied veterinary science
    • Research Institution
      KYOTO UNIVERSITY
  •  慢性骨髄性白血病を発症するSPA-1遺伝子破壊マウスを用いた免疫監視機構の研究Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  SPA-1遺伝子破壊マウスを用いた慢性骨髄性白血病発症に関わる免疫監視機構の研究Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Regulation and Control of Immune Surveillance

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  A new model mice for human chronic myelogenous leukemia by the disruption of SPA-1 gene.Principal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      KYOTO UNIVERSITY
  •  低分子G蛋白シグナル系を介した骨髄微小環境形成の分子機構の解析Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  ヒトγδ型T細胞を用いた特異的癌免疫療法の開発

    • Principal Investigator
      TANAKA Yoshimasa
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Pattern recognition by human γδ T cells and innate immunity.

    • Principal Investigator
      TANAKA Yoshimasa
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  Regulation of T-cell and antigen-presenting cell interactions by Rapl.Principal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  造血系生成過程における低分子G蛋白シグナル系の関与Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割

    • Principal Investigator
      岩井 一宏
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  低分子G蛋白シグナル系を介した造血系細胞分化制御機構Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Kyoto University
  •  Essential role of transcriptional regulator Hesl in the early development of T cells.Principal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割

    • Principal Investigator
      IWAI Kazuhiro
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  Molecular mechanisms of lymphocyte proliferation during the development

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  核内GTPase活性化蛋白の機能制御に関与する細胞内蛋白質限定分解機構の解析Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  細胞周期調節機構における核内GTPase活性化蛋白の機能Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  MHC非拘束性T細胞の抗原レセプターと認識抗原の研究

    • Principal Investigator
      湊 長博
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  Nuclear small G protein system involved in cell cycle.

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      KYOTO UNIVERSITY
  •  Molecular mechanisms for cell cycle control in the immune system

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  Development of avian component vaccine with built-in adjuvanting potencial.

    • Principal Investigator
      KON Yasuhiro, 佐藤 文昭
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Applied veterinary science
    • Research Institution
      HOKKAIDO UNIVERSITY
  •  Cell cycle regulation of a lympho-hematopoietic specific Rap1GTPase-activating protein, Spa-1 in lymphocyres.Principal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  核に局在するsmallG蛋白系による細胞増殖調節機構の解析Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  造血組織に局在する新しいT細胞亜群の認識レパートリーの研究

    • Principal Investigator
      湊 長博
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  骨髄局在T細胞の認識レパートリー形成に関わる新しい拘束因子とその制御

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kyoto University
  •  Analysis of Ligands Involved in the T-cell Receptor Repartoire Formation of T-cells Lecalized in Hematopoiatic Tissues.

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  Analysis of a lympho-hematopoietic specific nuclear protein with homology to RaplGAPPrincipal Investigator

    • Principal Investigator
      HATTORI Masakazu
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      KYOTO UNIVERSITY
  •  Studies on the Signal Transduction in T Lymphocytes via Antigen and Lymphokine Receptors.

    • Principal Investigator
      MINATO Nagahiro
    • Project Period (FY)
      1990 – 1991
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      Jichi Medical School
  •  Large granular lymphocytesの初期分化に関する研究Principal Investigator

    • Principal Investigator
      服部 雅一
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      基礎獣医学
    • Research Institution
      Hokkaido University

All 2020 2019 2017 2016 2015 2014 2012 2011 2010 2009 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book Patent

  • [Book] 獣医微生物学 第2版2003

    • Author(s)
      服部 雅一
    • Total Pages
      379
    • Publisher
      文永堂出版
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590337
  • [Journal Article] Physiology and pathology of T-cell aging.2020

    • Author(s)
      Minato Nagahiro、Hattori Masakazu、Hamazaki Yoko
    • Journal Title

      International Immunology

      Volume: 32 Pages: 223-231

    • DOI

      10.1093/intimm/dxaa006

    • NAID

      120006936327

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K19442, KAKENHI-PROJECT-17H03925, KAKENHI-PROJECT-18K19268
  • [Journal Article] The impact of senescence-associated T cells on immunosenescence and age-related disorders.2019

    • Author(s)
      Fukushima Y, Minato N, Hattori M
    • Journal Title

      Inflammation and Regeneration

      Volume: 38 Pages: 24-30

    • DOI

      10.1186/s41232-018-0082-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18K19268, KAKENHI-PROJECT-17H03925
  • [Journal Article] The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine2017

    • Author(s)
      Ito K, Nakajima A1, Fukushima Y1, Suzuki K1, Sakamoto K, Hamazaki Y, Ogasawara K, Minato N, and Hattori M.
    • Journal Title

      PLOS ONE

      Volume: 12

    • DOI

      10.1371/journal.pone.0173629

    • NAID

      120006488574

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-24111008, KAKENHI-PLANNED-16H06497, KAKENHI-PROJECT-16H05530, KAKENHI-PROJECT-26450443, KAKENHI-PROJECT-15K19075, KAKENHI-PROJECT-15K15151, KAKENHI-PUBLICLY-15H01154, KAKENHI-PROJECT-17H03925
  • [Journal Article] Osteopontin in spontaneous germinal centers inhibits apoptotic cell engulfment and promotes anti-nuclear antibody production in lupus-prone mice.2016

    • Author(s)
      Sakamoto、K., Fukushima、Y., Itoh、K., Matsuda, M., Nagata, S., Minato, N., and Hattori, M.
    • Journal Title

      The Journal of Immunology

      Volume: 197 Pages: 2177-2186

    • DOI

      10.4049/jimmunol.1600987

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PLANNED-24111008, KAKENHI-PROJECT-26450443, KAKENHI-PROJECT-15K19075, KAKENHI-PROJECT-15H05785
  • [Journal Article] A CD153+ CD4+ T follicular cell population with cell-senescence features plays a crucial role in lupus pathogenesis via osteopontin production2015

    • Author(s)
      1.Tahir S, Fukushima Y, Sakamoto K, Sato K, Fujita H, Inoue J, Uede T, Hamazaki Y, Hattori M, Minato N.
    • Journal Title

      J. Immunol.

      Volume: 194 Pages: 5725-35

    • DOI

      10.4049/jimmunol.1500319

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26450443, KAKENHI-PROJECT-26460066, KAKENHI-PROJECT-15K15151, KAKENHI-PUBLICLY-25111505, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24590580, KAKENHI-PUBLICLY-15H01154, KAKENHI-PLANNED-24111008
  • [Journal Article] T-cell senescence and Autoimmune diseases2015

    • Author(s)
      服部雅一,湊 長博
    • Journal Title

      アレルギー

      Volume: 64 Pages: 110-118

    • NAID

      110009917671

    • Data Source
      KAKENHI-PROJECT-26450443
  • [Journal Article] SPA-1 controls the invasion and metastasis of human prostate cancer.2011

    • Author(s)
      Yosuke Shimizu, Yoko Hamazaki, Masakazu Hattori, Keiko Doi, Naoki Terada, Takashi Kobayashi, Yoshinobu Toda, Toshinari Yamasaki, Takahiro Inoue, Yoichiro Kajita, Atsushi Maeno, Tomomi Kamba, Yoshiki Mikami, Toshiyuki Kamoto, Tomomi Yamada, Toru Kanno, Kiyotsugu Yoshikawa, Osamu Ogawa, Nagahiro Minato, Eijiro Nakamura.
    • Journal Title

      Cancer Sci 102

      Pages: 828-836

    • NAID

      10029292527

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20591855
  • [Journal Article] Spa-1 (Sipa1)and Rap signaling in leukemia and cancer metastasis.2009

    • Author(s)
      Minato N & Hattori M
    • Journal Title

      Cancer Science 100

      Pages: 17-23

    • NAID

      10025141008

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20380160
  • [Journal Article] Intestinal tumors inactivated in TGF-b signaling secrete CCL9 and recruit CCR1+ myeloid cells that help invasion.2007

    • Author(s)
      Kitamura, T., Kometani, K., Hashiba, H., Matsunaga, A., Miyoshi.H., Hosogi, H., Aoki, M., Oshima, M., Hattori, M., Takabayashi, A., Minato, N., Taketo, M.
    • Journal Title

      Nature Gen. 39

      Pages: 467-475

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Regulation of immune responses and hematopoiesis by the Rap1 signal. (Review)2007

    • Author(s)
      Minato, N, K.Kometani, M.Hattori.
    • Journal Title

      Adv. Immunol. 93

      Pages: 229-264

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Rapl Signal Controls B Cell Receptor Repertoire and Generation of Self-reactive B1 Cells2006

    • Author(s)
      Ishida, D., Su, L., Shinozuka, Y., Tamura, A., Katayama, Y., Kawai, Y., Wang, S-F, Taniwaki, M., Hamazaki, Y., Hattori, M., Minato, N.
    • Journal Title

      Immunity 24

      Pages: 417-427

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Role of SPA-1 in phenotypes of CML induced by BCR-ABL-expressing hematopoietic progenitors in mouse model.2006

    • Author(s)
      Kometani, K., Kawamata, S., Shinozuka, Y., Era, T., Taniwaki, M., Hattori, M., Minato, N.
    • Journal Title

      Cancer Res. 66

      Pages: 9967-9976

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] BCR/ABL and IL-3 activate Rap1 to stimulate B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion.2006

    • Author(s)
      Jin, A., Kurosu, T., Tsuji, K., Mizuchi, D., Arai, A., Fujita, H., Hattori, M., Minato, N., Miura, 0.
    • Journal Title

      Oncogene 20

      Pages: 4332-4340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Prethymic stage of T cell development defined by the expression of paired immunoglobulin-like receptors.2005

    • Author(s)
      Masuda, K., Kubagawa, H., Cooper, M.D., Kakugawa, K., Hattori, M., Kageyama, R., Minato, N., Katsura, Y., H.Kawamoto.
    • Journal Title

      EMBO J. 24

      Pages: 4052-4060

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Minato-Hes-1 directly controls cell proliferation through the transcriptional repression of p27Kipl.2005

    • Author(s)
      Murata, K, M.Hattori, N, Hirai, Y, Shinozuka, H, Hirata, R, Kageyama, T, Sakai, N
    • Journal Title

      Mol.Cell.Biol. 25

      Pages: 4262-4271

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] 1 Bromodomain protein Brd4 binds to the GTPase activating SPA-1 modulating its activity and subcellular localization.2004

    • Author(s)
      Farina, A., Hattori, M., Qin, J., Nakatani, Y., Minato, N., Ozato, K.
    • Journal Title

      Mol.Cell.Biol. 24

      Pages: 9059-9069

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Rapl and SPA-1 in hematologic malignancy. (Review)2004

    • Author(s)
      Kometani, K., Ishida, D., Hattori, M., Minato, N.
    • Journal Title

      Trends in Mol. Med. 10

      Pages: 401-408

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Myeloproliferative stem cell disorders by deregulated Rapl activation in SPA-1-deficient mice.2003

    • Author(s)
      Ishida D, Kometani, K., Yang, H, Kakugawa, K., Masuda, K, Iwai, K, Suzuki, M, Itohara, S, Nakahata, T, Hiai, H, Kawamoto, H., Hattori, M, Minato, N.
    • Journal Title

      Cancer Cell 4

      Pages: 55-65

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Functions, regulation, and malignancy. (Review).2003

    • Author(s)
      Hattori, M., Minato, N.Rapl GTPase
    • Journal Title

      J. Biochem. 134

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Rapl GTPase : Functions, regulation, and malignancy.2003

    • Author(s)
      Hattori, M., (他2名)
    • Journal Title

      J. Biochem. 134

      Pages: 479-484

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] 2003.., and Minato, N. AF-6 negatively regulates integrin-mediated cell adhesion by binding both Rap1GTP and Rapl GTPase-activating proteins and enhancing Rapl inactivation.

    • Author(s)
      Su, L., Hattori, M., Moriyama, M., Murata, N., Harazaki, M., Kaibuchi, K
    • Journal Title

      J. Biol. Chem. 278

      Pages: 15232-15238

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Journal Article] Antigen-driven T cell anergy and defective memory T cell response via deregulated Rapl activation in SPA-1-deficient mice.

    • Author(s)
      Ishida, D., Yang, H., Masuda, K., Uesugi, K., Kawamoto, H., Hattori, M., Minato.N.
    • Journal Title

      Proc. Natl. Acad. Sci. USA 100

      Pages: 10919-10924

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15078204
  • [Patent] オステオポンチン産生抑制剤2014

    • Inventor(s)
      服部雅一
    • Industrial Property Rights Holder
      服部雅一
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-215211
    • Filing Date
      2014-10-22
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Patent] 粘膜、上皮および鼓膜の少なくとも一つの再生材および再生評価法2010

    • Inventor(s)
      宮下武憲, 森望, 西望, 安達栄治郎, 松下治, 服部雅一, 伊藤周平, 坂本恵子
    • Industrial Property Rights Holder
      国立大学法人香川大学、学校法人北里研究所
    • Industrial Property Number
      2010-110694
    • Filing Date
      2010-05-12
    • Data Source
      KAKENHI-PROJECT-22300167
  • [Patent] 抗原特異的モノクローナル産生ハイブリドーマの作製方法および抗原特異的モノクローナル抗体の製造方法2010

    • Inventor(s)
      服部雅一, ら
    • Industrial Property Rights Holder
      北里大学東レ
    • Industrial Property Number
      2010-279636
    • Filing Date
      2010-11-22
    • Data Source
      KAKENHI-PROJECT-20380160
  • [Patent] 抗原特異的モノクローナル産生ハイブリドーマの作製方法および抗原特異的モノクローナル抗体の製造方法2010

    • Inventor(s)
      服部雅一, ら
    • Industrial Property Rights Holder
      北里大学東レ
    • Industrial Property Number
      2010-279636
    • Filing Date
      2010-11-22
    • Data Source
      KAKENHI-PROJECT-22658096
  • [Patent] 粘膜、上皮および鼓膜の少なくとも一つの再生材および再生評価法2010

    • Inventor(s)
      宮下武憲、森望、西望、安達栄治郎、松下治、服部雅一、伊藤周平、坂本恵子
    • Industrial Property Rights Holder
      国立大学法人香川大学、学校法人北里研究所
    • Industrial Property Number
      2010-110694
    • Filing Date
      2010-05-12
    • Data Source
      KAKENHI-PROJECT-22300167
  • [Presentation] 老化関連T細胞の誘導メカニズムとその制御2017

    • Author(s)
      服部雅一
    • Organizer
      第38回日本炎症・再生医学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-17H03925
  • [Presentation] CD153-CD30 interaction is involved in immunosenescence of T cells and spontaneous germinal center reactions2016

    • Author(s)
      Fukushima Y, Yamada H, Yoshikai Y, Minato N, Hattori M.
    • Organizer
      日本免疫学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      2016-12-05
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Presentation] Osteopontin produced by CD153+ follicular T cells suppresses apoptotic cell-engulfment by tingible body macrophages in germinal centers to accelerate SLE in NZB/W F1 mice.2016

    • Author(s)
      Sakamoto K, Nagata S, Minato N, Hattori M
    • Organizer
      Keystone symposia "T Follicular Helper Cells and Germinal Centers"
    • Place of Presentation
      Hyatt Regency Monterey
    • Year and Date
      2016-02-26
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Presentation] Osteopontin accelerates the formation of spontaneous germinal centers in NZB/W F1 mice via inhibition of apoptotic cell-engulfment by tingible body macrophages.2015

    • Author(s)
      Sakamoto K, Nagata S, Minato N, Hattori M
    • Organizer
      日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Presentation] Accumulation of naive TMRMlo CD4 T cells promotes generation and functional polarozation of effector cells leading to enhanced germinal center reactions in lupus-prone NZB/W F1 mice.2015

    • Author(s)
      Fukushima Y, Hattori M
    • Organizer
      日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Presentation] Osteopontin-secreting TCRgd+CD8+ intraepithelial lymphocyte maintains homeostasis of commensal bacteria in the intestine.2015

    • Author(s)
      Ito K, Fukushima Y, Sakamoto K, Minato N, Hattori M
    • Organizer
      日本免疫学会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Presentation] タイレリア感染による宿主細胞アポトーシス回避機構の解明2012

    • Author(s)
      林田京子、服部雅一、梶野喜一、Maura Wallace、Ivan Morrison、杉本千尋
    • Organizer
      第153回日本獣医学会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Year and Date
      2012-03-29
    • Data Source
      KAKENHI-PROJECT-21248035
  • [Presentation] COX-2^+ tumor-infiltrating DCs suppress anti-tumor immunity in tumor tissue.2010

    • Author(s)
      井上浄, 服部雅一
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-20380160
  • [Presentation] Intracellular recognition of LPS activates TRIF-dependent pathway and induces typeI IFN-dependent Th1 differentiation.2010

    • Author(s)
      渡邊幸子, 井上浄, 服部雅一
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-22658096
  • [Presentation] Intracellular recognition of LPS activates TRIF-dependent pathway and induces typel IFN-dependent Th1 differentiation.2010

    • Author(s)
      渡邊幸子, 井上浄, 服部雅一
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-20380160
  • [Presentation] COX-2^+ tumor-infiltrating DCs suppress anti-tumor immunity in tumor tissue.2010

    • Author(s)
      井上浄, 服部雅一
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-08-23
    • Data Source
      KAKENHI-PROJECT-22658096
  • [Presentation] Notch3によるNKT細胞の活性化制御2009

    • Author(s)
      井上浄, 服部雅一
    • Organizer
      日本免疫学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20380160
  • [Presentation] Senescence associated follicular CD4+ T cell population underlies systemic lupus erythematosus.

    • Author(s)
      Tahir S, Fukushima Y, Sakamoto K, Sato K, Hamazki Y, Hattori M, Minato N.
    • Organizer
      日本免疫学会
    • Place of Presentation
      京都国際会議場
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-26450443
  • [Presentation] Osteopontin is involved in the formation of spontaneous germinal centers in NZB/W F1 mice via the inhibition of apoptotic cell-engulfment.

    • Author(s)
      Sakamoto K, Minato N, Hattori M
    • Organizer
      Keystone symposia "Autoimmunity and Tolerance"
    • Place of Presentation
      Keystone Resort
    • Year and Date
      2015-02-03 – 2015-02-08
    • Data Source
      KAKENHI-PROJECT-26450443
  • 1.  MINATO Nagahiro (40137716)
    # of Collaborated Projects: 25 results
    # of Collaborated Products: 15 results
  • 2.  IWAI Kazuhiro (60252459)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 3.  TANAKA Yoshimasa (90280700)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  KUBOTA Hiroshi (80263094)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  SUGIMOTO Chihiro (90231373)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 6.  福島 祐二 (90583146)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  NAKAMURA Eijirou (90293878)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 8.  YOSHIMURA Kouji (40397542)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 9.  OGAWA Osamu (90260611)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 10.  KANEMATSU Akihiro (90437202)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  ADACHI Eijiro (30110430)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  AKAIKE Toshihiro (30101207)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  TAGAWA Youichi (70262079)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  NISHIYAMA Toshio (60372455)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  MATSUSHITA Osamu (00209537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  MASHIMO Tomoji (80397554)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  KON Yasuhiro (10178402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  ITO Toshihiro (00176348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  FUJII Nobuhiro (90133719)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  SHUDO Bunei (60001533)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  ENDOH Daiji (40168828)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  KUWABARA Mikinori (10002081)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  KAGEYAMA Ryuichiro (80224369)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  INOUE Noboru (10271751)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  HATTORI Masahira (70175537)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  SUGAWARA Hideaki (80231372)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  ABE Takashi (30390628)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  WATANABE Junichi (20201189)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  NAKAJIMA Yoshiaki (10300724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  西山 博之 (20324642)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  宗田 武 (50422928)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  大橋 和彦 (90250498)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  梶野 喜一 (80322147)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 34.  佐藤 文昭 (10162471)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  福井 宣規 (60243961)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  木梨 達雄 (30202039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  渡邊 武 (40028684)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  玄 学南 (10292096)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  保富 康宏 (90281724)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  MARUTA Hiroshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  牧 与志幸
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  田中 雅之
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  INOUE Joe
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  ITO KOYU
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 45.  濱崎 洋子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 3 results
  • 46.  長田 重一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  小笠原 康悦
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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