HATTORI Takayuki 服部隆行

Researcher Number	50377751
Other IDs
Affiliation (based on the past Project Information) *help	2014 – 2018: 国立医薬品食品衛生研究所, 遺伝子医薬部, 主任研究官 2011 – 2013: 国立医薬品食品衛生研究所, 機能生化学部, 主任研究官 2006: 浜松医科大学, COE研究員 2006: 浜松医科大学, 医学部, 研究員 2005 – 2006: Hamamatsu University School of Medicine, Department of Biochemistry 1, Post-doctorial Fellow, 医学部, COE研究員
Review Section/Research Field	Principal Investigator Drug development chemistry / Functional biochemistry Except Principal Investigator General medical chemistry / Functional biochemistry / Biological pharmacy
Keywords	Principal Investigator Ras / タンパク質分解 / ユビキチンリガーゼ / 蛋白質分解 / p27^<Kip1> / CDK阻害蛋白質 / 細胞周期 / 細胞癌化 / p27^<Kipl> / 癌 … More Except Principal Investigator 細胞周期 / ユビキチン / プロテアソーム / RB / Cell cycle / サイクリン / p27 / RBタンパク質 / 癌化 / Mdm2 / ubiquitin / p27^<Kip1> / 分解 / p27<kip1> / p27kip1 / Ubiquitin / Proteasome / Degradation / タンパク質分解 / プロテインノックダウン / SNIPER / エストロゲン受容体 / アンドロゲン受容体 / BCR-ABL / タンパク質 / Hisタグ / 蛋白質 Less

Manipulation of cellular function by forced ubiquitylation
- Principal Investigator
  
  NAITO MIKIHIKO
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  National Institute of Health Sciences
Mechanism of Shiga toxin-induced cell death and development of therapeutic agentPrincipal Investigator
- Principal Investigator
  
  HATTORI TAKAYUKI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Development of novel molecular target drug for activated Ras protein by the specific protein degradation systemPrincipal Investigator
- Principal Investigator
  
  HATTORI TAKAYUKI
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
Development of novel antitumor drugs targeting activated Ras by protein knockdownPrincipal Investigator
- Principal Investigator
  
  HATTORI Takayuki
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Health Sciences
個体レベルでの細胞周期のリアルタイムイメージングの試み
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
CDK阻害蛋白質p27^<Kip1>の新規ユビキチンリガーゼの細胞癌化への関与Principal Investigator
- Principal Investigator
  
  服部隆行
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hamamatsu University School of Medicine
Degradation of the CDK inhibitor p27^<Kip1> by a novel ubiquitin ligase.
- Principal Investigator
  
  UCHIDA Chiharu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hamamatsu University School of Medicine
Regulation of tumor suppressor RB pathway via ubiquitin system.
- Principal Investigator
  
  KITAGAWA Masatoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Hamamatsu University School of Medicine

All 2019 2018 2017 2016 2015 2013 2012 2011 2006

All Journal Article Presentation Book

[Book] Estrogen Receptors Methods and Protocols2016
- Author(s)
  1.Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Kurihara M, Naito M
- Total Pages
  576
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-15K08040
[Book] 細胞周期集中マスター「第6章ユビキチンシステムによる細胞周期制御」2006
- Author(s)
  服部隆行
- Total Pages
  154
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-17770110
[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019
- Author(s)
  Shibata Norihito、Ohoka Nobumichi、Hattori Takayuki、Naito Mikihiko
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 67 Issue: 3 Pages: 165-172
- DOI
  10.1248/cpb.c18-00703
- NAID
  130007606378
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-PROJECT-18K07311, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019
- Author(s)
  Ohoka Nobumichi、Ujikawa Osamu、Shimokawa Kenichiro、Sameshima Tomoya、Shibata Norihito、Hattori Takayuki、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  CHEMICAL & PHARMACEUTICAL BULLETIN
  
  Volume: 67 Issue: 3 Pages: 203-209
- DOI
  10.1248/cpb.c18-00567
- NAID
  130007607114
- ISSN
  0009-2363, 1347-5223
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.2018
- Author(s)
  Shibata Norihito、Shimokawa Kenichiro、Nagai Katsunori、Ohoka Nobumichi、Hattori Takayuki、Miyamoto Naoki、Ujikawa Osamu、Sameshima Tomoya、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Pages: 13549-13549
- DOI
  10.1038/s41598-018-31913-5
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Development of a small hybrid molecule that mediates degradation of His tag-fused proteins2018
- Author(s)
  K. Okitsu, T. Hattori, T. Misawa, T. Shoda, M. Kurihara, M. Naito, Y. Demizu
- Journal Title
  
  . Med. Chem.
  
  Volume: 61 Pages: 576-582
- DOI
  10.1021/acs.jmedchem.7b00413
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-17K08385
[Journal Article] Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor alpha degradation.2018
- Author(s)
  Ohoka Nobumichi、Morita Yoko、Nagai Katsunori、Shimokawa Kenichiro、Ujikawa Osamu、Fujimori Ikuo、Ito Masahiro、Hayase Youji、Okuhira Keiichiro、Shibata Norihito、Hattori Takayuki、Sameshima Tomoya、Sano Osamu、Koyama Ryokichi、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  J Biol Chem
  
  Volume: 293 Pages: 6776-6790
- DOI
  10.1074/jbc.ra117.001091
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-18K06567, KAKENHI-ORGANIZER-18H05497, KAKENHI-PLANNED-18H05502, KAKENHI-PROJECT-16H05090
[Journal Article] Targeting the Allosteric Site of Oncoprotein BCR-ABL as an Alternative Strategy for Effective Target Protein Degradation2017
- Author(s)
  Shimokawa Kenichiro、Shibata Norihito、Sameshima Tomoya、Miyamoto Naoki、Ujikawa Osamu、Nara Hiroshi、Ohoka Nobumichi、Hattori Takayuki、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  ACS Medicinal Chemistry Letters
  
  Volume: 8 Pages: 1042-1047
- DOI
  10.1021/acsmedchemlett.7b00247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands2017
- Author(s)
  Shibata Norihito、Nagai Katsunori、Morita Yoko、Ujikawa Osamu、Ohoka Nobumichi、Hattori Takayuki、Koyama Ryokichi、Sano Osamu、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Journal of Medicinal Chemistry
  
  Volume: 61 Pages: 543-575
- DOI
  10.1021/acs.jmedchem.7b00168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] Targeted Degradation of Proteins Localized in Subcellular Compartments by Hybrid Small Molecules2017
- Author(s)
  Okuhira, K., Shoda, T., Omura, R., Ohoka, N., Hattori, T., Shibata, N., Demizu, Y., Sugihara, R., Ichino, A., Kawahara, H., Itoh, Y., Ishikawa, M., Hashimoto, Y., Kurihara, M., Itoh, S., Saito, H. & Naito, M.
- Journal Title
  
  Mol Pharmacol
  
  Volume: 91 Pages: 159-166
- DOI
  10.1124/mol.116.105569
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-25293027, KAKENHI-PROJECT-26305006, KAKENHI-PROJECT-16K08236, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-17H03979
[Journal Article] Simple and efficient knockdown of His-tagged proteins by ternary molecules consisting of a His-tag ligand, a ubiquitin ligase ligand, and a cell-penetrating peptide2017
- Author(s)
  T. Hattori, K. Okitsu, N. Yamazaki, N. Ohoka, N. Shibata, T. Misawa, M. Kurihara, Y. Demizu,* M. Naito*
- Journal Title
  
  Bioorganic & Medicinal Chemistry Letters
  
  Volume: 27 Pages: 4478-4481
- DOI
  10.1016/j.bmcl.2017.08.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08385, KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121
[Journal Article] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2017
- Author(s)
  Shibata Norihito、Miyamoto Naoki、Nagai Katsunori、Shimokawa Kenichiro、Sameshima Tomoya、Ohoka Nobumichi、Hattori Takayuki、Imaeda Yasuhiro、Nara Hiroshi、Cho Nobuo、Naito Mikihiko
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1657-1666
- DOI
  10.1111/cas.13284
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-16K15121
[Journal Article] SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib2017
- Author(s)
  Ohoka, N., Nagai, K., Shibata, N., Hattori, T., Nara, H., Cho, N. & Naito, M.
- Journal Title
  
  Cancer Science
  
  Volume: 108 Pages: 1032-1041
- DOI
  10.1111/cas.13198
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121
[Journal Article] In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic IAP-dependent Protein Erasers (SNIPERs).2017
- Author(s)
  Ohoka, N., Okuhira, K., Ito, M., Nagai, K., Shibata, N., Hattori, T., Ujikawa, O., Shimokawa, K., Sano, O., Koyama, R., Fujita, H., Teratani, M., Matsumoto, H., Imaeda, Y., Nara, H., Cho, N. & Naito, M.
- Journal Title
  
  J Biol Chem.
  
  Volume: 292 Pages: 4556-4570
- DOI
  10.1074/jbc.m116.768853
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K08236
[Journal Article] Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand2016
- Author(s)
  Demizu, Y., Shibata, N., Hattori, T., Ohoka, N., Motoi, H., Misawa, T., Shoda, T., Naito, M. & Kurihara, M.
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 26 Pages: 1865-4869
- DOI
  10.1016/j.bmcl.2016.09.041
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-26860085, KAKENHI-PROJECT-16K08340, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-16K15121, KAKENHI-PROJECT-16K18916
[Journal Article] M-COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin2016
- Author(s)
  Hattori T, Watanabe-Takahashi M, Shiina I, Ohashi Y, Dan S, Nishikawa K, Yamori T, Naito M.
- Journal Title
  
  Genes Cells
  
  Volume: 21(8) Pages: 901-906
- DOI
  10.1111/gtc.12386
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05105, KAKENHI-PROJECT-15K08040
[Journal Article] Protein Knockdown Technology: Application of Ubiquitin Ligase to Cancer Therapy.2016
- Author(s)
  Ohoka, N., Shibata, N., Hattori, T. & Naito, M.
- Journal Title
  
  Curr Cancer Drug Targets
  
  Volume: 16 Pages: 136-146
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16H05090
[Journal Article] A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool2016
- Author(s)
  Hiroko Yamashita, Makoto Oba, Takashi Misawa, Masakazu Tanaka, Takayuki Hattori, Mikihiko Naito, Masaaki Kurihara, Yosuke Demizu
- Journal Title
  
  chembiochem
  
  Volume: 17 Pages: 137-140
- DOI
  10.1002/cbic.201500468
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-15K18905
[Journal Article] Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERalpha.2016
- Author(s)
  K. Okuhira, Y. Demizu, T. Hattori, N. Ohoka, N. Shibata, T. Nishimaki-Mogami, H. Okuda, M. Kurihara, M. Naito*
- Journal Title
  
  Methods Mol Biol
  
  Volume: 1366 Pages: 549-560
- DOI
  10.1007/978-1-4939-3127-9_42
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460169, KAKENHI-PROJECT-26860049, KAKENHI-PROJECT-26860050, KAKENHI-PROJECT-25430164, KAKENHI-PROJECT-16H05090
[Journal Article] Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin2015
- Author(s)
  Takayuki Hattori, Miho Watanabe-Takahashi, Nobumichi Ohoka, Takashi Hamabata, Koichi Furukawa, Kiyotaka Nishikawa, and Mikihiko Naito
- Journal Title
  
  FEBS Open Bio.
  
  Volume: 5 Pages: 605-614
- DOI
  10.1016/j.fob.2015.06.005
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08040, KAKENHI-PROJECT-15H04696
[Presentation] In vivo protein knockdown by chimeric small-compound SNIPERs.2018
- Author(s)
  Nobumichi Ohoka, Yoko Morita, Katsunori Nagai, Kenichiro Shimokawa, Osamu Ujikawa, Ikuo Fujimori, Masahiro Ito, Youji Hayase, Keiichiro Okuhira, Norihito Shibata, Takayuki Hattori, Tomoya Samejima, Osamu Sano, Ryokichi Koyama, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinases2018
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Derivatization of IAP ligand to develop SNIPERs with improved protein knockdown and antitumor activity2018
- Author(s)
  Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Mikihiko Naito
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPを利用したプロテインノックダウン法の開発とがん原性タンパク質の分解2018
- Author(s)
  内藤幹彦、大岡伸通、柴田識人、服部隆行
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands2018
- Author(s)
  Norihito Shibata, Naoki Miyamoto, Katsunori Nagai, Kenichiro Shimokawa, Tomoya Sameshima, Nobumichi Ohoka, Takayuki Hattori, Yasuhiro Imaeda, Hiroshi Nara, Nobuo Cho, Mikihiko Naito
- Organizer
  日本薬学会第138年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] IAPアンタゴニストLCL161誘導体を導入したSNIPERによる効果的なプロテインノックダウン2017
- Author(s)
  大岡伸通、奥平桂一郎、伊東昌宏、永井克典、柴田識人、服部隆行、宇治川治、下川賢一郎、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第21回日本がん分子標的治療学会　学術集会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、永井克典、奥平桂一郎、柴田識人、服部隆行、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] プロテインノックダウン法を利用したアンドロゲン受容体蛋白質分解誘導剤の開発2017
- Author(s)
  柴田識人、大岡伸通、服部隆行、永井克典、伊東昌宏、奈良洋、長展生、内藤幹彦
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Targeting the allosteric site of oncogenic BCR-ABL protein as an alternative strategy for effective protein degradation2017
- Author(s)
  Norihito Shibata, Kenichiro Shimokawa, Tomoya Sameshima, Naoki Miyamoto, Osamu Ujikawa, Hiroshi Nara, Nobumichi Ohoka, Takayuki Hattori, Nobuo Cho, Mikihiko Naito
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Degradation of target proteins by SNIPER compounds recruiting IAP ubiquitin ligases2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  EMBO conference　Ubiquitin and SUMO
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチンープロテアソーム系を介したHisタグタンパク質分解誘導分子の開発2017
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会第136年会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2017-03-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Degradation of oncogenic proteins by SNIPER compounds.2017
- Author(s)
  Mikihiko Naito, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 芳香族炭化水素受容体ユビキチンリガーゼをリクルートする新しいプロテインノックダウン化合物の開発2017
- Author(s)
  大岡伸通、柴田識人、服部隆行、内藤幹彦
- Organizer
  第76回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウン2016
- Author(s)
  大岡伸通、奥平桂一郎、柴田識人、服部隆行、内藤幹彦
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 網羅的人工ユビキチン修飾システムの構築2016
- Author(s)
  服部隆行，正田卓司，奥平桂一郎，柴田識人，大岡伸通，伊藤進，栗原正明，内藤幹彦
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] BCR-ABL の蛋白質分解誘導剤開発を指向した BCR-ABL 結合化合物の探索2016
- Author(s)
  柴田識人，大岡伸通，服部隆行，橋井則貴，斎藤臣雄，近藤恭光，石井明子，長田裕之，内藤幹彦
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] Development of hybrid small molecules that induce degradation of oncogenic BCR-ABL2016
- Author(s)
  Norihito Shibata, Nobumichi Ohoka, Takayuki Hattori, Mikihiko Naito
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 環境応答型二次構造変化を利用した細胞膜高透過性ペプチドの開発2016
- Author(s)
  山下博子，出水庸介，加藤巧馬，大岡伸通，三澤隆史，服部隆行，田中正一，内藤幹彦，大庭誠，栗原正明
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] 志賀毒素耐性THP-1細胞の単離と解析2016
- Author(s)
  服部隆行，高橋美帆，西川喜代孝，内藤幹彦
- Organizer
  第２０回腸管出血性大腸菌感染症研究会
- Place of Presentation
  富山県・富山市
- Year and Date
  2016-11-10
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] 低分子化合物SNIPERによる細胞内ユビキチン化機能の制御と創薬への利用2016
- Author(s)
  大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] Protein knockdown by SNIPER compounds: Application for basic research and cancer therapy2016
- Author(s)
  Mikihiko Naito, Takayuki Hattori, Nobumichi Ohoka, Norihito Shibata, Takuji Shoda, Yosuke Demizu, Masaaki Kurihara
- Organizer
  Tenth AACR/JCA Joint Conference
- Place of Presentation
  ハワイ
- Year and Date
  2016-02-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] Hisタグタンパク質分解誘導分子の開発2016
- Author(s)
  沖津航陽，服部隆行，出水庸介，三澤隆史，正田卓司，内藤幹彦，栗原正明
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] がん遺伝子YAPを標的としたプロテインノックダウン法の確立2016
- Author(s)
  中野なおこ、正田卓司、服部隆行、栗原正明、内藤幹彦、伊東進
- Organizer
  第20回日本がん分子標的治療学会学術集会
- Place of Presentation
  別府コンベンションセンター（大分県別府市）
- Year and Date
  2016-05-30
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 低分子化合物SNIPERによるin vivoプロテインノックダウンと抗腫瘍活性評価2016
- Author(s)
  大岡伸通、奥平桂一郎、永井克典、伊東昌宏、柴田識人、服部隆行、宇治川治、佐野修、小山亮吉、今枝泰宏、奈良洋、長展生、内藤幹彦
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜国際会議場（神奈川県横浜市）
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ユビキチン・プロテアソーム経路を利用したプロテインノックダウン化合物の開発2016
- Author(s)
  大岡伸通，伊東昌宏，奥平桂一郎，永井克典，柴田識人，服部隆行，長展生，内藤幹彦
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] 低分子化合物による網羅的人工ユビキチン化システムの構築2016
- Author(s)
  服部隆行、正田卓司、奥平桂一郎、柴田識人、大岡伸通、伊東進、栗原正明、内藤幹彦
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] ヘリカルプロモーター導入によるオリゴアルギニンの構造制御と膜透過能への効果2016
- Author(s)
  三澤隆史，山下博子，加藤巧馬，服部隆行，大庭誠，田中正一，内藤幹彦，出水庸介，栗原正明
- Organizer
  日本薬学会第１３６年会
- Place of Presentation
  横浜市
- Year and Date
  2016-03-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] 細胞内His タグタンパク質分解誘導剤の開発2016
- Author(s)
  沖津航陽、服部隆行、出水庸介、三澤隆史、正田卓司、内藤幹彦、栗原正明
- Organizer
  第60回日本薬学会関東支部大会
- Place of Presentation
  東京大学（東京）
- Data Source
  KAKENHI-PROJECT-16H05090
[Presentation] 細胞膜透過性の向上を指向したカチオン性アミノ酸の合成およびその応用2015
- Author(s)
  山下博子，出水庸介，三澤隆史，服部隆行，大庭誠，田中正一，内藤幹彦，栗原正明
- Organizer
  第４１回反応と合成の進歩シンポジウム
- Place of Presentation
  東大阪市
- Year and Date
  2015-10-26
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] DDSキャリアを指向したカチオン性非天然アミノ酸導入ペプチドの開発2015
- Author(s)
  山下博子，出水庸介，三澤隆史，大庭誠，田中正一，服部隆行，内藤幹彦，栗原正明
- Organizer
  第３１会日本DDS学会学術集会
- Place of Presentation
  東京都
- Year and Date
  2015-07-02
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] プロテアソーム阻害による志賀毒素誘導性細胞死の抑制2015
- Author(s)
  服部隆行，高橋美帆，椎名勇，大橋愛美，旦慎吾，西川喜代孝，内藤幹彦
- Organizer
  第１９回腸管出血性大腸菌感染症研究会
- Place of Presentation
  東京都
- Year and Date
  2015-07-09
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] 新規小胞輸送阻害薬を用いた志賀毒素のアポトーシス死誘導活性の抑制2015
- Author(s)
  服部隆行，高橋美帆，椎名勇，大橋愛美，旦慎吾，西川喜代孝，内藤幹彦
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] Development of his-tag fused protein degradation inducer based on a protein knockdown strategy2015
- Author(s)
  Koyo Okitsu, Takayuki Hattori, Yosuke Demizu, Takashi Misawa, Takuji Shoda, Mikihiko Naito, Masaaki Kurihara
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] Development of helix-stabilized cationic peptides with cell-membrane penetrating ability2015
- Author(s)
  Hiroko Yamashita, Yosuke Demizu, Takashi Misawa, Takayuki Hattori, Makoto Oba, Masakazu Tanaka, Mikihiko Naito, Masaaki Kurihara
- Organizer
  第52回ペプチド討論会
- Place of Presentation
  平塚市
- Year and Date
  2015-11-16
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015
- Author(s)
  大岡伸通，柴田識人，服部隆行，内藤幹彦
- Organizer
  第74回日本癌学会学術総会
- Place of Presentation
  名古屋市
- Year and Date
  2015-10-08
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] ユビキチン化誘導剤によって起こるユビキチン関連死の解明2015
- Author(s)
  大岡伸通，永井克典，服部隆行，柴田識人，長展生，内藤幹彦
- Organizer
  第38回日本分子生物学会年会・第88回日本生化学会大会合同大会
- Place of Presentation
  神戸市
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] TACC3分解誘導剤によるがん細胞のユビキチン関連死2015
- Author(s)
  大岡伸通，服部隆行，内藤幹彦
- Organizer
  日本がん分子標的治療学会第１９回学術集会
- Place of Presentation
  松山市
- Year and Date
  2015-06-10
- Data Source
  KAKENHI-PROJECT-15K08040
[Presentation] Distinct phosphorylation of the retinoblastoma protein at serine 612 in differentiated cells2013
- Author(s)
  Takayuki Hattori, Chiharu Uchida, Hirotaka Takahashi, Naoki Yamamoto, Mikihiko Naito, Yoichi Taya.
- Organizer
  Ninth AACR/JCA Joint Conference
- Place of Presentation
  Hawaii, U S A
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] 細胞膜透過性蛍光 NTA の設計・合成2013
- Author(s)
  加藤雅士,正田卓司,出水庸介,井上英史,服部隆行,内藤幹彦,栗原正明
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] 細胞分化に伴うRBタンパク質のセリン612の特異異的リン酸化.2013
- Author(s)
  服部隆行,内田千晴,高橋宏隆,山本直樹,内藤幹彦,田矢洋一
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] Development of SNIPER(ER) that induces estrogen receptor degradation followed by rapidcell death in breast cancer cells2013
- Author(s)
  Keiichiro Okuhira, Yosuke Demizu, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko Nishimaki-Mogami, Masaaki Kurihara, Haruhiro Okuda, Mikihiko Naito.
- Organizer
  Ninth AACR/JCA Joint Conference
- Place of Presentation
  Hawaii, U S A
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] 分化細胞におけるRB タンパク質のserine612 の部位特異的リン酸化2012
- Author(s)
  服部隆行,田矢洋一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] Development of Hybrid Small Molecules That Induce IAP-Mediated Ubiquitylation and Proteasomal Degradation of Target Proteins in a Specific Manner2012
- Author(s)
  Mikihiko Naito, Keiichiro Okuhira, Yosuke Demizu, Yukihiro Itoh, Minoru Ishikawa, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko Nishimaki-Mogami, Masaaki Kurihara, and Yuichi Hashimoto
- Organizer
  Genetics and Chemistry Sharing a Language of Discovery
- Place of Presentation
  Boston, USA
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] シガトキシンBサブユニットによる細胞死誘導機構2012
- Author(s)
  服部隆行,大岡伸通,高橋美帆,西川喜代孝,内藤幹彦
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] Degradation of Estrogen Receptor Induced by a Small Hybrid Molecule SNIPER (ER)2012
- Author(s)
  Keiichiro Okuhira, Yosuke Demizu, Nobumichi Ohoka, Norihito Shibata, Takayuki Hattori, Tomoko-Nishimaki Mogami, Masaaki Kurihara, Haruhiro Okuda, and Mikihiko Naito
- Organizer
  The 16th Japanese Foundation for Cancer Research-International Symposium on Cancer Chemotherapy
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] プロテインノックダウン法によるエストロゲンレセプターの分解2012
- Author(s)
  奥平桂一郎,出水庸介,大岡伸通, 柴田識人,服部隆行,最上(西巻) 知子,栗原正明,奥田晴宏,内藤幹彦
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-23890251
[Presentation] プロテインノックダウン法によるエストロゲン受容体の分解2011
- Author(s)
  奥平桂一郎,出水庸介,大岡伸通, 柴田織人,服部隆行,最上(西巻)知子,栗原正明,奥田晴宏,内藤幹彦
- Organizer
  第70回日本癌学会総会
- Place of Presentation
  名古屋市
- Data Source
  KAKENHI-PROJECT-23890251

1. KITAGAWA Masatoshi (50294971)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. UCHIDA Chiharu (60223567)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KITAGAWA Kyoko (20299605)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. ODA Toshiaki (90126805)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. NAITO MIKIHIKO (00198011)

# of Collaborated Projects: 1 results

# of Collaborated Products: 35 results
6. DEMIZU YOSUKE

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
7. ISHIKAWA Minoru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SYODA Takuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
9. MISAWA Takashi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 古川鋼一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 大岡伸通

# of Collaborated Projects: 0 results

# of Collaborated Products: 13 results
12. 伊藤拓水

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
13. 伊東進

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 奥平桂一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
15. 栗原正明

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
16. 斎藤博幸

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 柴田識人

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
18. 旦慎吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

HATTORI Takayuki 服部 隆行

Research Projects

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Co-Researchers

Manipulation of cellular function by forced ubiquitylation

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Mechanism of Shiga toxin-induced cell death and development of therapeutic agentPrincipal Investigator

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Development of novel molecular target drug for activated Ras protein by the specific protein degradation systemPrincipal Investigator

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Development of novel antitumor drugs targeting activated Ras by protein knockdownPrincipal Investigator

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個体レベルでの細胞周期のリアルタイムイメージングの試み

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CDK阻害蛋白質p27^<Kip1>の新規ユビキチンリガーゼの細胞癌化への関与Principal Investigator

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Degradation of the CDK inhibitor p27^<Kip1> by a novel ubiquitin ligase.

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Regulation of tumor suppressor RB pathway via ubiquitin system.

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[Book] Estrogen Receptors Methods and Protocols2016

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[Book] 細胞周期集中マスター「第6章 ユビキチンシステムによる細胞周期制御」2006

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[Journal Article] Development of a Potent Protein Degrader against Oncogenic BCR-ABL Protein2019

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[Journal Article] Different Degradation Mechanisms of Inhibitor of Apoptosis Proteins (IAPs) by the Specific and Nongenetic IAP-Dependent Protein Eraser (SNIPER)2019

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[Journal Article] Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase.2018

Author(s)

HATTORI Takayuki 服部隆行

[Book] 細胞周期集中マスター「第6章ユビキチンシステムによる細胞周期制御」2006