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Suzuki Masaaki  鈴木 正昭

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… Alternative Names

鈴木 正昭  スズキ マサアキ

SUZUKI Masaaki  鈴木 正昭

鈴木 正明  スズキ マサアキ

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Researcher Number 90093046
External Links
Affiliation (Current) 2021: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 研究員
Affiliation (based on the past Project Information) *help 2018 – 2020: 国立研究開発法人国立長寿医療研究センター, 認知症先進医療開発センター, 研究員
2018: 国立研究開発法人国立長寿医療研究センター, その他部局等, 研究員
2017: 国立研究開発法人国立長寿医療研究センター, 脳機能画像診断開発部, 研究員
2015: 国立研究開発法人国立長寿医療研究センター, 能機能画像診断開発部, 特任研究員
2015: 国立研究開発法人国立長寿医療研究センター, 脳機能画像診断開発部, 研究員 … More
2014: 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発部, 研究員
2013: 独立行政法人国立長寿医療研究センター, 脳機能画像診断開発部, 特任研究員
2009 – 2011: 独立行政法人理化学研究所, 分子イメージング科学研究センター, 副センター長
2009: 独立行政法人理化学研究所, 分子イメージング科学研究センター, 副所長
2006: 岐阜大学, 医学系研究科, 教授
2005: 岐阜大学, 大学院医学系研究科, 教授
2002 – 2004: 岐阜大学, 大学院・医学研究科, 教授
1993 – 2001: Gifu University, department of technology, progessor, 工学部, 教授
2000: Department of Biomolecular Science, Faculty of Engineering, Gifu University, Professor, 工学部・生命工学, 教授
1999: 岐阜大学, 工学部・生命工学科, 教授
1992: 名古屋大学化学測定機器センター, 助教授
1990 – 1992: 名古屋大学, 化学測定機器センター, 助教授
1987 – 1989: 名古屋大学, 理学部, 助教授
1986: 名大, 理学部, 助教授 Less
Review Section/Research Field
Principal Investigator
Bioorganic chemistry / 天然物有機化学 / Biomolecular chemistry / Medium-sized Section 37:Biomolecular chemistry and related fields
Except Principal Investigator
Cerebral neurosurgery / Pathological medical chemistry / General pharmacology / Living organism molecular science / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related / Radiation science / Basic Section 52040:Radiological sciences-related
Keywords
Principal Investigator
15R-TIC / PET / プロスタサイクリン / IP_2 / APNIC / イソカルバサイクリン / 受容体 / 光親和性標識 / プロスタグランジン / 15-deoxy-TIC … More / プロスタサイクリン受容体 / GS-Xポンプ / 光親和性標識法 / 受容体探索子 / Δ^7-PGA_1 / in vivo / イメージング / 有機合成 / 高速メチル化 / キナーゼ / Prostacyclin / Receptor / PET法 / 抗アポトーシス作用 / アポトーシス / がん化肥満細胞 / ぶた血小板 / プロスタグランジンF_2α / PGI_2 / PKC / 光アフィニディラベリング / Ca^<2+> / 抗腫瘍性プロスタグランジン / スニホニルウレア / 脳 / 分子プローブ / 受容体リガンド / 蛍光プローブ / 人工核酸 / 阻害剤 / 神経因性疼痛 / シグナル解析 / 3成分連結PG合成法 / non-RI光親和性標識法 / ABCトランスポーター / Socius / 神経性疼痛 / プラナーポジトロンイメージング / MicroPET / レチノイド / キナーゼ阻害剤 / 34mCl / プロスグランジン / RXRアンタゴニスト / 可視化プローブ / 4'-チオリボヌクレオシド / ダントロレン誘導体 / Cu-ATSM / サリドマイド / リピドA / リアノジン受容体 / PGE_2 / アロディニア / DNAチップ / 11C標識 / PET分子イメージング / ギンゴライド&ジンセノサイド / 脳移行性 / 糖輸送体 / PETプローブ / 11C,18F-標識化 / 認知症改善薬ギンゴライド&ギンセノシド / グルコーストランスポーター / クロスメタセシス / PET分子プローブ / 分子イメージング / グルコース / 高速クロスカップリング / クロスメタセシス反応 / 認知症(脳機能)改善漢方薬成分 / ギンゴライド / ギンセノシド / 高速クロスカップリング反応 / PG;オータコイド / 3成分連結法 / PG【E_2】の合成 / PG【F_2】αの合成 / プロスタサイクリンの合成 / PG一般合成法 / 受容体タンパク質 / クローニング / Isocarbacyclin / △^7-PGA_1メチルエステル / 光親和性標識リガンド / 代謝安定性 / GS-Xポンプ阻害剤 / BiP / 中枢神経系 / 抗腫瘍性PG / 受容体機能解析 / カルシウムシグナル / プロテインキナーゼ / 分子設計 / 機能探索分子 / カルシウム / 探索分子 / 受容体の機能解析 / 情報分子の可視化 / 合成化合物 / セカンドメッセンジャー / 構造機能解析 / Prostaglandin / Calciun / Kinese / Molecular Probe / Imagining / 神経保護作用 / 高速メチル化反応 / 血液-脳関門 / NEPP11 / 15-deoxy-TICメチルエステル / 脳虚血 / アポトーシス阻害 / MRP / Neuroprotective effect / Rapid methylation / BBB / NEPP 11 / IP_2受容体 / 脳保護作用 / ^<11>C[CH_3] / 神経突起伸展促進 / 制癌性PG / apoptosis / brain / O6-メチルグアニン-DNA-トランスフェラーゼ / O6-ベンジルグアニン / 遺伝子変異イソクエン酸脱水素酵素1 / α-ケトグルタル酸 / 11C標識分子プローブ … More
Except Principal Investigator
プロスタグランジン / 脳腫瘍 / 15R-TIC / BINAP / 陽電子断層撮像法 / PET / アルツハイマー病 / 制がん性PG / △^7ーPGA_1 / 交叉ジエノン構造 / プロスタイクリン / 受容体タンパク質 / 光親知性標識法 / 抗腫瘍性プロスタグランジン / グルタチオン抱合体 / GS-Xポンプ / シスプラチン耐性HL-60 / 光親和性標識プローブ / 耐性克服 / 薬剤耐性 / グルタチオン / シスプラチン耐性HL-60細胞 / 分子プローブ / 光親和性標識 / 抗腫瘍性 / シスプラチン耐性細胞 / HL60 / c-myc遺伝子 / 分子設計 / 機能探索分子 / プロテインキナーゼ / G蛋白質共役受容体 / Ca^<2+>イメージング / カルシウムシグナリング / ケミカルバイオロジー / ケミカルジェネティクス / 疾患ケミカルバイオロジー / リン酸化酵素阻害剤 / バイオイメージングプローブ / PETプローブ / アフィニティ磁性ナノビーズ / 創薬 / エピジェネティクス / 癌幹細胞 / エピジェネテュクス / ヒストン / メチル化 / 治療 / 分子イメージング / 分子イメーグング / MGMT / PETトレーサー / 分子 / イメージング / 有機合成 / 臨床応用 / プロスタグランジンE_2 / プロスタグランジンF_<2α> / プロスタグランジンI_2 / 受容体 / クローニング / G蛋白 / プロスタグランジンF_<2alpha> / 牛副腎髄質 / PCR / 牛卵巣黄体 / Prostaglandin E_2 / Prostaglandin F_<2alpha> / Prostaglandin I_2 / Receptor / Cloning / プロスタサイクリン / アポトーシス / 神経細胞死 / 海馬 / 中隔 / Prostacyclin / Prostaglandin / Apoptosis / Neuronal death / Hippocampus / Septum / 新有機化学反応 / 有機,鉛化合物 / 高選択的1,4ー付加反応 / パラジウム(0)錯体触媒 / 新脱保護法 / 不斉水素化 / DAIB / 有機亜鉛 / アルキル化 / 不斉クライゼン転位 / アリル系保護基 / 超純度DNA合成 / 超原子価スズ化合物 / 分子内エン反応 / アミノアルコール / 有機亜鉛化合物 / アシロキシボラン / 不斉DielsーAlder反応 / BINAP錯体 / プロスタグランジン合成 / DNA固相合成 / 不斉アルキル化 / 有機アルミニウム / 不斉増幅 / 不斉触媒 / O価バラジウム / 2-5A / アントラサイクリン / アリルオキシカルボニル / パラジウム / イソカルバサイクリン / ルテニウム錯体 / 1-βメチルチエナマイシン / ナブロキャン / シトロネロール / ビタミン / BINAL-H / TMSOTf / BINAP-Rh / BINAP-Ru / MAD / CAB / Pd(0)Catalyzed deprotection / 非環式レチノイド / 11C標識分子プローブ / プロドラッグ / 脳内移行性 / イソプロテレノール / マイクロドーズ試験 / アルツハイマー / タウ蛋白 / 被曝線量 / MIRD法 / マイクログリア / ミクログリア / 神経炎症 / CSF1R Less
  • Research Projects

    (28 results)
  • Research Products

    (45 results)
  • Co-Researchers

    (80 People)
  •  特異的発現酵素を標的とした脳腫瘍イメージングPETプローブの斬新化Principal InvestigatorOngoing

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 37:Biomolecular chemistry and related fields
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Synthesis of 11C-labeled acyclic retinoids with high brain permeabilityOngoing

    • Principal Investigator
      古山 浩子
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
    • Research Institution
      Gifu University
  •  PET imaging of microglia, a novel drug target for neurodegenerative diseasesOngoing

    • Principal Investigator
      木村 泰之
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52040:Radiological sciences-related
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementia

    • Principal Investigator
      Ito Kengo
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Radiation science
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Development of PET probes of neuroprotective molecular components in oriental medicinesPrincipal Investigator

    • Principal Investigator
      SUZUKI Masaaki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biomolecular chemistry
    • Research Institution
      National Center for Geriatrics and Gerontology
  •  Chemical biology reprogramming epigenetic aberration in malignant brain tumors

    • Principal Investigator
      NATSUME Atsushi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Nagoya University
  •  Development of molecular imaging tracers for anticancer drug resistant proteins

    • Principal Investigator
      WAKABAYASHI Toshihiko
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cerebral neurosurgery
    • Research Institution
      Nagoya University
  •  ケミカルジェネティクスによる生体機能の解明

    • Principal Investigator
      萩原 正敏
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Living organism molecular science
    • Research Institution
      Tokyo Medical and Dental University
  •  生物新機能と創薬をめざす生体内分子科学Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2001 – 2005
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Gifu University
  •  生体内分子科学Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Creative Basic Research
    • Research Institution
      Gifu University
  •  Biological Functions and Designed Probe CompoundsPrincipal Investigator

    • Principal Investigator
      SUZUKI Masaaki, 日高 弘義
    • Project Period (FY)
      1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gifu University
      Nagoya University
  •  Development of Anti-apoptoic Drugs for Neuronal Cells and Distribution Analysis in BrainPrincipal Investigator

    • Principal Investigator
      SUZUKI Masaaki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Gifu University
  •  Neuroprotctive effects of CNS-specific prostacyclin receptro ligands

    • Principal Investigator
      SATOH Takumi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  Novel PET Tracers for Prostaglandin ReceptorsPrincipal Investigator

    • Principal Investigator
      SUZUKI Masaaki
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Gifu University
  •  標的分子の構造情報に基づく分子設計及び有機合成Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Gifu University
  •  超高感度プロスタグランジン受容体プローブの設計と活用Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  機能探索設計分子の開発とその評価

    • Principal Investigator
      日高 弘義
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University
  •  プロスタグランジン:生物活性分子機構Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Gifu University
  •  超高感度プロスタグランジン受容体プローブの設計と活用Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  制がん性プロスタグランジンの科学的および生物学的研究

    • Principal Investigator
      野依 良治
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Nagoya University
  •  超高感度プロスタグランジン受容体プローブの設計と活用Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Gifu University
  •  プロスタグランジン受容体に関する有機化学的研究Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Gifu University
  •  Design of specific Molecular Probes for a Prostacyclin ReceptorPrincipal Investigator

    • Principal Investigator
      SUZUKI Masaaki
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Bioorganic chemistry
    • Research Institution
      Gifu University
  •  光親和性プロスタサイクリン受容体探索子の設計および活用に基づく受容体の同定Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      天然物有機化学
    • Research Institution
      Nagoya University
  •  Cloning of prostaglandin E receptor cDNAs and molecular mechanisms of activation

    • Principal Investigator
      ITO Seiji
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      Osaka Bioscience Institute
  •  制がん性プロスタグランジン類の設計と合成

    • Principal Investigator
      NOYORI Ryoji
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Nagoya University
  •  Development of New Organic Reactions and Synthesis of Physiologically Active Substance

    • Principal Investigator
      NOYORI Ryoji
    • Project Period (FY)
      1987 – 1990
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Research Institution
      Nagoya University
  •  プロスタグランジン類の短段階一般合成法Principal Investigator

    • Principal Investigator
      鈴木 正昭
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      天然物有機化学
    • Research Institution
      Nagoya University

All 2020 2019 2018 2017 2016 2015 2014 2013 2005 2004

All Journal Article Presentation

  • [Journal Article] Brain pharmacokinetics and biodistribution of 11C-labeled isoproterenol in rodents2020

    • Author(s)
      Ogata Aya、Kimura Yasuyuki、Ikenuma Hiroshi、Yamada Takashi、Abe Junichiro、Koyama Hiroko、Suzuki Masaaki、Ichise Masanori、Kato Takashi、Ito Kengo
    • Journal Title

      Nuclear Medicine and Biology

      Volume: -

    • DOI

      10.1016/j.nucmedbio.2020.06.002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Journal Article] Synthesis of (R,S)-isoproterenol, an inhibitor of tau aggregation, as an 11C-labeled PET tracer via reductive alkylation of (R,S)-norepinephrine with [2-11C]acetone2019

    • Author(s)
      Ikenuma Hiroshi、Koyama Hiroko、Kajino Naoya、Kimura Yasuyuki、Ogata Aya、Abe Junichiro、Kawasumi Yasuhiro、Kato Takashi、Takashima Akihiko、Ito Kengo、Suzuki Masaaki
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Pages: 2107-2111

    • DOI

      10.1016/j.bmcl.2019.07.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Journal Article] Detection of cyclooxygenase-1 in activated microglia during amyloid plaque progression: PET studies in Alzheimer’s disease model mice2016

    • Author(s)
      Miho Shukuri, Aya Mawatari, Masahiro Ohno, Masaaki Suzuki, Hisashi Doi, Yasuyoshi Watanabe, Hirotaka Onoe
    • Journal Title

      J. Nucl. Med.

      Volume: 57 Pages: 291-296

    • DOI

      10.2967/jnumed.115.166116

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09904, KAKENHI-PROJECT-25242070
  • [Journal Article] Synthesis of a Vpr-binding derivative for use as a novel HIV-1 inhibitor2015

    • Author(s)
      Kyoji Hagiwara, Hideki Ishii, Tomoyuki Murakami, Shin-nosuke Takashima, Nopporn Chutiwitoonchai, Eiichi N Kadama, Kumi Kawai, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Yasuo Tsunetsugu-Yokota, Masaaki Suzuki, Yoko Aida
    • Journal Title

      PLoS One

      Volume: 12

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Journal Article] A novel [11C]-labeled thymidine analog, [11C]AZT, for tumor imaging by positron emission tomography2015

    • Author(s)
      Tsuyoshi Tahara, Zhouen Zhang, Masahiro Ohno, Yukako Hirano, Nami Hasaka, Hisashi Doi, Masaaki Suzuki, and Hirotaka onoe
    • Journal Title

      EJNMMI Res.

      Volume: 5 Pages: 45-45

    • DOI

      10.1186/s13550-015-0124-0

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residue with 1,2-dihydroxybenzene groups2015

    • Author(s)
      Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A
    • Journal Title

      Nature Commun.

      Volume: 6 Pages: 10216-10216

    • DOI

      10.1038/ncomms10216

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26350976, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Synthesis of 11C-labeled thiamine and fursulthiamine for in vivo molecular imaging of vitamin B1 and its prodrug using positron emission tomography2015

    • Author(s)
      Hisashi Doi, Aya Mawatari, Masakatsu Kanazawa, Satoshi Nozaki, Yukihiro Nomura, Takahito Kitayoshi, Kouji Akimoto, Masaaki Suzuki, Shinji Ninomiya, Yasuyoshi Watanabe
    • Journal Title

      J. Org. Chem.

      Volume: 80 Pages: 6250-6258

    • DOI

      10.1021/acs.joc.5b00685

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Journal Article] 11C-labeled capsaicin and its in vivo molecular imaging in rats by positron emission tomography.2015

    • Author(s)
      Goto Miki, Mizuma Hiroshi, Wada Yasuhiro, Suzuki Masaaki, Watanabe Yasuhiro, Onoe Hirotaka, Doi Hisashi
    • Journal Title

      Food Nutrit.Sci.

      Volume: 6 Pages: 216-220

    • DOI

      10.4236/fns.2015.62022

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Journal Article] Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation.2014

    • Author(s)
      Masaaki Suzuki, Misato Takashima-Hirano, Hideki Ishii, Chika Watanabe, Kengo Sumi, Hiroko Koyama, Hisashi Doi,
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 3622-3625

    • DOI

      10.1016/j.bmcl.2014.05.041

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24590156, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Quantitative evaluation of the improvement in the pharmacokinetics of a nucleic acid drug delivery system by dynamic PET imaging with 18F-incorporated oligodeoxynucleotides.2014

    • Author(s)
      H. Mukai, D. Ozaki, Y. Cui, T. Kuboyama, H. Yamato-Nagata, K. Onoe, M. Takahashi, Y. Wada, T. Imanishi, T. Kodama, S. Obika,* M Suzuki, H. Doi, Y. Watanabe
    • Journal Title

      J. Controlle Release

      Volume: 180 Pages: 92-99

    • DOI

      10.1016/j.jconrel.2014.02.014

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24249007, KAKENHI-PROJECT-25242070
  • [Journal Article] 11C-Cetrozole: An improved C-11C-methylated PET probe for aromatase imaging in the brain.2014

    • Author(s)
      Kayo Takahashi, Takamitsu Hosoya, Kayo Onoe, Hisashi, Doi, Hiroko Nagata, Toshiyuki Hiramatsu, Xiao-Le Li, Yumiko Watanabe, Yasuhiro Wada, Tadayuki Takashima, Masaaki Suzuki, Hirotaka Onoe, Yasuyoshi, Watanabe
    • Journal Title

      Journal of Nuclear Medicine

      Volume: 55 Pages: 852-857

    • DOI

      10.2967/jnumed.113.131474

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25830024
  • [Journal Article] Efficient syntheses of [11C]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C-[11C]methylation2014

    • Author(s)
      Zhouen Zhang, Hisashi Doi, Hiroko Koyama, Yasuyoshi Watanabe, Masaaki Suzuki
    • Journal Title

      J. Labelled Compd. Radiopharm.

      Volume: 57 Pages: 540-549

    • DOI

      10.1002/jlcr.3213

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] 11C-labeling of the C(1)-C(10) dihydroxy acid moiety for the study on the synthesis of kulokekahilide-2 PET tracer.2014

    • Author(s)
      Chunguang Han, Hisashi Doi, Junji Kimura, Yoichi Nakao, and Masaaki Suzuki
    • Journal Title

      Int. J. Org. Chem.

      Volume: 4 Pages: 269-277

    • DOI

      10.4236/ijoc.2014.44029

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Journal Article] IOP lowering effect of isoquinoline-5-sulfonamide compounds on ocular normotensive monkey.2014

    • Author(s)
      Kengo Sumi, Yoshihiro Inoue, Masahiro Nishio, Yasuhito Naito, Takamitu Hosoya, Masaaki Suzuki, Hiroyoshi Hidaka
    • Journal Title

      Bioorg. Med. Chem. Lett.

      Volume: 24 Pages: 831-834

    • DOI

      10.1016/j.bmcl.2013.12.085

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Journal Article] Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes2014

    • Author(s)
      Masaaki Suzuki, Hisashi Doi, Hiroko Koyama, Zhang Zhouen, Takamitsu Hosoya, Hirotaka Onoe, Yasuyoshi Watanabe
    • Journal Title

      Chem. Rec.

      Volume: 14 Pages: 516-541

    • DOI

      10.1002/tcr.201400002

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Pd0-mediated rapid coupling of methyl iodide with excess amounts of pinacol benzyl- and cinnamylboronic acid estsers: efficient method for incorporation of positron-emitting 11C radionuclide into organic frameworks by coupling between two sp3-hybridized carbons2013

    • Author(s)
      Hiroko Koyama, Zhouen Zhang, Ryosuke Ijuin, Siqin, Jeongwan Son, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki
    • Journal Title

      RSC Advances

      Volume: 3 Pages: 9391-9401

    • DOI

      10.1039/c3ra40815a

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: PET Imaging after Oral Administration of Non-absorbable Marker, [18F]Deoxyfluoropoly(ethylene glycol)2013

    • Author(s)
      Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K, Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y
    • Journal Title

      Mol. Pharmacol.

      Volume: 10 Pages: 2261-2269

    • DOI

      10.1021/mp300469m

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659049, KAKENHI-PROJECT-25242070
  • [Journal Article] Synthesis of an 11C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography.2013

    • Author(s)
      Tsutomu Kimura, Takeo Sako, Siqin, Junji Hosokawa-Muto, Yi Long Cui, Yasuhiro Wada, Yosky Kataoka, Hisashi Doi, Suehiro Sakaguchi, Masaaki Suzuki, Yasuyoshi Watanabe, Kazuo Kuwata
    • Journal Title

      ChemMedChem

      Volume: 8(7) Pages: 1035-1039

    • DOI

      10.1002/cmdc.201300167

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23370068, KAKENHI-PROJECT-24570180, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460399
  • [Journal Article] Evaluation of Oatp and Mrp2 activities in hepatobiliary excretion using newly developed positron emission tomography (PET) tracer, [11C]dehydropravastatin, in rats2013

    • Author(s)
      Shingaki T, Takashima T, Ijuin R, Zhang X, Onoue T, Katayama Y, Okauchi T, Hayashinaka E, Cui Y, Wada Y, Suzuki M, Maeda K, Kusuhara H, Sugiyama Y, Watanabe Y.
    • Journal Title

      J. Pharmacol. Exp. Ther.

      Volume: 347 Pages: 193-202

    • DOI

      10.1124/jpet.113.206425

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23136101, KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-24659574, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Evaluation of TlOH effect for Pd0-mediated cross-coupling of methyl iodide and excess boronic acid ester toward fabrication of [11C]CH3-incorporated PET tracer2013

    • Author(s)
      Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
    • Journal Title

      Int. J. Org. Chem.

      Volume: 3 Pages: 220-223

    • DOI

      10.4236/ijoc.2013.33030

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
  • [Journal Article] Evaluation of Bcrp Function in Hepatobiliary and Renal Excretion using PET with [11C]SC-628072013

    • Author(s)
      Takashima T, Wu C, Takashima-Hirano M, Katayama Y, Wada Y, Suzuki M, Kusuhara H, Sugiyama Y and Watanabe Y.
    • Journal Title

      J Nucl Med.

      Volume: 54 Pages: 267-276

    • DOI

      10.2967/jnumed.112.110254

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24229002, KAKENHI-PROJECT-25242070, KAKENHI-PLANNED-23136101
  • [Journal Article] PET トレーサー合成基盤を刷新する高速メチル化反応 : プロスタグランジン受容体の可視化2005

    • Author(s)
      鈴木正昭
    • Journal Title

      科学と生物 43

      Pages: 804-808

    • NAID

      10016846717

    • Data Source
      KAKENHI-PROJECT-13NP0401
  • [Journal Article] Rapid methylation on carbon frameworks leading to the synthesis of a PET tracer capable of imaging a novel CNS-type prostacyclin receptor in living human brain2004

    • Author(s)
      M.Suzuki
    • Journal Title

      Trends in Analytical Chemistry 23・8

      Pages: 595-607

    • Data Source
      KAKENHI-PROJECT-13NP0401
  • [Journal Article] ミニレビュー脳を探る分子プローブ設計:ヒト脳内IP_2受容体の分子イメージング2004

    • Author(s)
      鈴木正昭
    • Journal Title

      日本神経精神薬理学雑誌 24

      Pages: 221-229

    • Data Source
      KAKENHI-PROJECT-13NP0401
  • [Journal Article] Positron Emission Tomography (PET)法による生体の分子イメージング研究と創薬・医療への応用2004

    • Author(s)
      鈴木正昭
    • Journal Title

      生物物理 44・6

      Pages: 265-270

    • Data Source
      KAKENHI-PROJECT-13NP0401
  • [Presentation] Improved (R,S)-[11C]isoproterenol formulation toward clinical study2019

    • Author(s)
      池沼宏、古山浩子、木村泰之、阿部潤一郎、川角保広、小縣綾、山田貴史、加藤隆司、伊藤健吾、鈴木正昭
    • Organizer
      第59回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] PET imaging of colony stimulating factor 1 receptor in rat brains.2019

    • Author(s)
      Ogata A, Kimura Y, Yamada T, Ichise M, Ikenuma H, Abe J, Koyama H, Suzuki M, Kato T, Ito K.
    • Organizer
      Brain & Brain PET 2019,
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02776
  • [Presentation] Colony stimulating factor 1 receptorを標的としたミクログリア特異的PETイメージングの開発2019

    • Author(s)
      小縣綾、木村泰之、山田貴史、市瀬正則、阿部潤一郎、池沼宏、古山浩子、鈴木正昭、加藤隆司、伊藤健吾
    • Organizer
      第59回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-18H02776
  • [Presentation] Formulation of 11C-labeled (R,S)-isoproterenol and pharmacokinetic studies in rats.2019

    • Author(s)
      Ikenuma H, Ogata A, Kimura Y, Koyama H, Abe J, Yamada T, Ichise M, Kato T, Suzuki M, Ito K
    • Organizer
      Brain & Brain PET 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] Development of PET imaging of Colony Stimulating Factor 1 Receptor Expressed on Microglia.2018

    • Author(s)
      Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
    • Organizer
      The XII International Symposium of Functional Neuroreceptor Mapping of the Living Brain
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02776
  • [Presentation] Synthesis of 11C-Labeled (R,S)-Isoproterenol and Preclinical PET Study2018

    • Author(s)
      Ikenuma H, Koyama H, Kajino N, Kimura Y, Ogata A, Abe J, Kawasumi Y, Kato T, Suzuki M, Ito K
    • Organizer
      The World Molecular Imaging Congress 2018
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] The evaluation of a novel PET ligand for colony stimulating factor 1 receptor in status epilepticus model rat brains.2018

    • Author(s)
      Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
    • Organizer
      nnual Congress of the European Association of Nuclear Medicine
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18H02776
  • [Presentation] Synthesis of highly-qualified 11C-labeled (R,S)-isoproterenol aimed at a clinical study2017

    • Author(s)
      Ikenuma H, Koyama H, Kimura Y, Abe J, Kawasumi K, Ogata A, Kato T, Ito K, Suzuki M.
    • Organizer
      The 12th Asia Oceania Congress of Nuclear Medicine and Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] 認知症治療薬としてのイソプロテレノールの小動物PETを用いたラット脳内移行性の検討2017

    • Author(s)
      小縣 綾、木村泰之、池沼 宏、古山浩子、関千江、山田貴史、鈴木正昭、加藤隆司、伊藤健吾
    • Organizer
      第57回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] Brain penetration of isoproterenol as a drug of dementia measured in rats with a micro-PET2017

    • Author(s)
      Ogata A, Kimura Y, Ikenuma H, Koyama H, Seki C, Yamada T, Suzuki M, Kato T, Ito K.
    • Organizer
      The 12th Asia Oceania Congress of Nuclear Medicine and Biology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] 臨床研究を目的とした11C標識化(R,S)-イソプロテレノールの高効率合成法の開発2017

    • Author(s)
      池沼 宏、古山浩子、木村泰之、阿部潤一郎、川角保広、小縣 綾、加藤隆司、伊藤健吾、鈴木正昭
    • Organizer
      第57回日本核医学会学術総会
    • Data Source
      KAKENHI-PROJECT-17H04269
  • [Presentation] The Chemistry to Life Science: Highly Potentiated C-C Couplings2016

    • Author(s)
      Masaaki Suzuki
    • Organizer
      King’s College London-Nagoya University Workshop in Cancer and Neuroscience
    • Place of Presentation
      Nagoya University
    • Year and Date
      2016-03-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] Evaluation of TlOH Effects for Pd0-Mediated Cross-Coupling of Methyl Iodide and Excess Boronic Acid Esters toward 11C-Incorporated PET Tracer Synthesis, Research area (10) Bench to Bedside2015

    • Author(s)
      Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] 11C-labeling of the C(1)-C(10) dihydroxy acid moiety for the study on the synthesis of kulokekahilide-2 PET tracer2015

    • Author(s)
      Chunguang Han, Hisashi Doi, Jyunji Kimura, Yoichi Nakao, Masaaki Suzuki
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] 疾患対応新規PET分子プローブの革新的合成法と医学生物学的活用2015

    • Author(s)
      鈴木正昭
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋市
    • Year and Date
      2015-10-08
    • Invited
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] Rh(I)-mediated rapid [11C]carboxylation using [11C]CO2 and organoborate at atmospheric pressure2015

    • Author(s)
      Miki Goto, Sachi Kurai, Ryo Yamamoto, Tomozumi Kanamitsu, Masaaki Suzuki, Yasuyohi Watanabe, Hisashi Doi
    • Organizer
      The International Chemical Congress of Pacific Basin Societies 2015
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      2015-12-15
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] A knack and pitfalls in the development of the novel 11C-labeled PET tracer synthesis2014

    • Author(s)
      Misato Takashima, Miho Shukuri, Mikako Ogawa, Yasuomi Ouchi, Hirotaka Onoe, Masaaki Suzuki, Yasuhiro Magata
    • Organizer
      The 15th Conference of Peace through Mind/Brain Science
    • Place of Presentation
      Hamamatsu
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] 脳内aromataseとヒトの性格・気質との関連―PET 研究2014

    • Author(s)
      高橋佳代、細谷孝充、高島忠之、田中雅彰、石井聰、中富康仁、田沢周作、高橋和弘、土居久志、和田康弘、鈴木正昭、尾上浩隆、渡辺恭良
    • Organizer
      日本分子イメージング学会 第9回学会総会・学術集会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] [11C]標識NSAIDsによるシクロオキシゲナーゼのPETイメージング2013

    • Author(s)
      尾上浩隆、宿里充穂、鈴木正昭、渡辺恭良
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡・福岡国際会議場
    • Data Source
      KAKENHI-PROJECT-25242070
  • [Presentation] Imaging of cyclooxygenase-1 in activated microglia by PET with S-enantiomer of 11C-ketoprofen-methyl ester2013

    • Author(s)
      Miho Shukuri, Aya Mawatari, Masahiro Ohno, Hisashi Doi, Masaaki Suzuki, Yasuyoshi Watanabe, Hirotaka Onoe
    • Organizer
      EANM'13-Annual Congress of the European Association of Nuclear Medicine
    • Place of Presentation
      France・Lyon
    • Data Source
      KAKENHI-PROJECT-25242070
  • 1.  WATANABE Yasuyoshi (40144399)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 2 results
  • 2.  KOYAMA Hiroko (50402160)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 20 results
  • 3.  NOYORI Ryoji (50022554)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  ITO Seiji (80201325)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 5.  木村 泰之 (20423171)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 13 results
  • 6.  NEGISHI Manabu (60201696)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  NATSUME Atsushi (30362255)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 8.  長野 哲雄 (20111552)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 9.  KITAMURA Masato (50169885)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  IINO Masamitsu (50133939)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  ICHIKAWA Atsushi (10025695)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  WAKABAYASHI Toshihiko (50220835)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  ISHII Hideki (80425610)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 14.  HOSOYA Takamitsu (60273124)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  日高 弘義 (80100171)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  松田 彰 (90157313)
    # of Collaborated Projects: 2 results
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  • 17.  袖岡 幹子 (60192142)
    # of Collaborated Projects: 2 results
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  • 18.  萩原 正敏 (10208423)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 19.  加藤 隆司 (60242864)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 13 results
  • 20.  小縣 綾 (10805857)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 21.  KONDO Yutaka (00419897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  TAKEUCHI Ichiro (40335146)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  DOI Hisashi (00421818)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 19 results
  • 24.  UMEMURA Kazuo (40232912)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  SAKAMOTO Kazuichi (90235169)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  YAMAMURA Hirohei (90030882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  FURUTA Kyoji (40173538)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  SATOH Takumi (10300831)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  MATSUMURA Kiyashi (10157349)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  MARUOKA Keiji (20135304)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  HAYAKAWA Yoshihiro (50022702)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  YAMAMOTO Hisashi (10135311)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  Ito Kengo (70184653)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 9 results
  • 34.  遠藤 實 (50009990)
    # of Collaborated Projects: 1 results
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  • 35.  野澤 義則 (10021362)
    # of Collaborated Projects: 1 results
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  • 36.  中山 仁 (70088863)
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  • 72.  崔 翼龍
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  • 79.  高島 明彦
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  • 80.  宮坂 知宏
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