Koyama Hiroko 古山浩子

… Alternative Names

Researcher Number	50402160
Other IDs
Affiliation (Current)	2020: 岐阜大学, 工学部, 准教授
Affiliation (based on the past Project Information) *help	2018 – 2019: 岐阜大学, 工学部, 准教授 2017: 岐阜大学, 工学部, 助教 2014 – 2015: 岐阜大学, 大学院医学系研究科, 助教 2012 – 2015: 岐阜大学, 医学(系)研究科(研究院), 助教 2011: 岐阜大学, 大学院・医学系研究科, 助教 2010 – 2011: 岐阜大学, 医学系研究科, 助教 2009: 岐阜大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Drug development chemistry / Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related Except Principal Investigator Cerebral neurosurgery / Drug development chemistry / Biomolecular chemistry / Radiation science / Basic Section 52040:Radiological sciences-related
Keywords	Principal Investigator PETプローブ合成 / アルキル－アルキル間クロスカップリング反応 / 高速反応 / ボロン化合物 / パラジウム触媒 / 鈴木・宮浦反応 / アルキル－アルキル間高速クロスカップリング反応 / 高速C-メチル化 / 高速C-[11C]メチル化 / 11C-標識法 … More Except Principal Investigator PET / 脳腫瘍 / 分子イメージング / 創薬 / イメージング / 陽電子断層撮像法 / アルツハイマー病 / エピジェネティクス / 癌幹細胞 / エピジェネテュクス / ヒストン / メチル化 / 治療 / 分子イメーグング / MGMT / PETトレーサー / 分子 / 有機合成 / 臨床応用 / 脳神経疾患 / 分子標的 / 核酸医療 / ナノテクノロジー / ロボティクス / 分子標的薬 / 薬物送達 / 化学療法 / 分子マーカー / 治療予後 / 神経膠腫 / 核酸療法 / 薬剤送達 / 天然物 / プロドラック / プローブ / ギンコライド / 11C標識 / PET分子イメージング / ギンゴライド＆ジンセノサイド / 脳移行性 / 糖輸送体 / PETプローブ / 11C,18F-標識化 / 認知症改善薬ギンゴライド＆ギンセノシド / グルコーストランスポーター / 高速メチル化 / クロスメタセシス / PET分子プローブ / グルコース / 高速クロスカップリング / クロスメタセシス反応 / 認知症(脳機能)改善漢方薬成分 / ギンゴライド / ギンセノシド / 高速クロスカップリング反応 / マイクロドーズ試験 / アルツハイマー / タウ蛋白 / イソプロテレノール / 被曝線量 / MIRD法 / マイクログリア / 神経炎症 / CSF1R / ミクログリア Less

Synthesis of 11C-labeled acyclic retinoids with high brain permeabilityPrincipal InvestigatorOngoing
- Principal Investigator
  
  古山浩子
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related
- Research Institution
  Gifu University
PET imaging of microglia, a novel drug target for neurodegenerative diseasesOngoing
- Principal Investigator
  
  木村泰之
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52040:Radiological sciences-related
- Research Institution
  National Center for Geriatrics and Gerontology
PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementiaOngoing
- Principal Investigator
  
  伊藤健吾
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Radiation science
- Research Institution
  National Center for Geriatrics and Gerontology
Development of PET probes of neuroprotective molecular components in oriental medicines
- Principal Investigator
  
  SUZUKI Masaaki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biomolecular chemistry
- Research Institution
  National Center for Geriatrics and Gerontology
Development of rapid C-methylation between two sp3-hybridized carbons for incorporation of short-lived positron-emitting 11C radionuclidePrincipal Investigator
- Principal Investigator
  
  Koyama Hiroko
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  Gifu University
Multimodal medical strategies by means of robotic technology according with molecular target imaging
- Principal Investigator
  
  Wakabayashi Toshihiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nagoya University
Synthesis of glycosylated derivatives of ginkgolides and in vivo evaluation of those pharmacokinetics
- Principal Investigator
  
  ISHII Hideki
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Drug development chemistry
- Research Institution
  National Institute of Radiological Sciences
  The Institute of Physical and Chemical Research
Chemical biology reprogramming epigenetic aberration in malignant brain tumors
- Principal Investigator
  
  NATSUME Atsushi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nagoya University
Development of molecular imaging tracers for anticancer drug resistant proteins
- Principal Investigator
  
  WAKABAYASHI Toshihiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  Nagoya University

All 2018 2017 2015 2014 2013 2010 2009 Other

All Journal Article Presentation

[Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residue with 1,2-dihydroxybenzene groups2015
- Author(s)
  Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A
- Journal Title
  
  Nature Commun.
  
  Volume: 6 Pages: 10216-10216
- DOI
  10.1038/ncomms10216
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26350976, KAKENHI-PLANNED-26117004, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes2014
- Author(s)
  Masaaki Suzuki, Hisashi Doi, Hiroko Koyama, Zhang Zhouen, Takamitsu Hosoya, Hirotaka Onoe, Yasuyoshi Watanabe
- Journal Title
  
  Chem. Rec.
  
  Volume: 14 Pages: 516-541
- DOI
  10.1002/tcr.201400002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Efficient syntheses of [11C]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C-[11C]methylation2014
- Author(s)
  Zhouen Zhang, Hisashi Doi, Hiroko Koyama, Yasuyoshi Watanabe, Masaaki Suzuki
- Journal Title
  
  J. Labelled Compd. Radiopharm.
  
  Volume: 57 Pages: 540-549
- DOI
  10.1002/jlcr.3213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation.2014
- Author(s)
  Masaaki Suzuki, Misato Takashima-Hirano, Hideki Ishii, Chika Watanabe, Kengo Sumi, Hiroko Koyama, Hisashi Doi,
- Journal Title
  
  Bioorg. Med. Chem. Lett.
  
  Volume: 24 Pages: 3622-3625
- DOI
  10.1016/j.bmcl.2014.05.041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24590156, KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Evaluation of TlOH effect for Pd0-mediated cross-coupling of methyl iodide and excess boronic acid ester toward fabrication of [11C]CH3-incorporated PET tracer2013
- Author(s)
  Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
- Journal Title
  
  Int. J. Org. Chem.
  
  Volume: 3 Pages: 220-223
- DOI
  10.4236/ijoc.2013.33030
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] Pd0-mediated rapid coupling of methyl iodide with excess amounts of pinacol benzyl- and cinnamylboronic acid estsers: efficient method for incorporation of positron-emitting 11C radionuclide into organic frameworks by coupling between two sp3-hybridized carbons2013
- Author(s)
  Hiroko Koyama, Zhouen Zhang, Ryosuke Ijuin, Siqin, Jeongwan Son, Yuma Hatta, Masashi Ohta, Masahiro Wakao, Takamitsu Hosoya, Hisashi Doi, Masaaki Suzuki
- Journal Title
  
  RSC Advances
  
  Volume: 3 Pages: 9391-9401
- DOI
  10.1039/c3ra40815a
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25242070, KAKENHI-PROJECT-25460147
[Journal Article] A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation2010
- Author(s)
  Motomura K, Ogura M, Natsume A, Yokoyama H, Wakabayashi T
- Journal Title
  
  Neuroscience Letters
  
  Volume: 485(1) Pages: 65-70
- Data Source
  KAKENHI-PROJECT-21390409
[Journal Article] A free-radical scavenger protects the neural progenitor cells in the dentate subgranular zone of the hippocampus from cell death after X-irradiation2010
- Author(s)
  Motomura, K., Ogura, M., Natsume, A., Yokoyama, H., and Wakabayashi, T
- Journal Title
  
  Neurosci Lett
  
  Volume: 485 Pages: 65-70
- Data Source
  KAKENHI-PROJECT-21390408
[Journal Article] Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling2009
- Author(s)
  Yuki K, Natsume A, Yokoyama H, Kondo Y, Ohno M, Kato T, Chansakul P, Ito M, Kim SU, Wakabayashi T.
- Journal Title
  
  Cancer Lett 284
  
  Pages: 71-79
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390408
[Journal Article] Induction of oligodendrogenesis in glioblastoma-initiating cells by IFN-mediated activation of STAT3 signaling2009
- Author(s)
  Yuki, K., Natsume, A., Yokoyama, H., Kondo, Y., Ohno, M., Kato, T., Chansakul, P., Ito, M., Kim, S. U., and Wakabayashi, T
- Journal Title
  
  Cancer Lett
  
  Volume: 284 Pages: 71-79
- Data Source
  KAKENHI-PROJECT-21390408
[Presentation] Synthesis of 11C-Labeled (R,S)-Isoproterenol and Preclinical PET Study2018
- Author(s)
  Ikenuma H, Koyama H, Kajino N, Kimura Y, Ogata A, Abe J, Kawasumi Y, Kato T, Suzuki M, Ito K
- Organizer
  The World Molecular Imaging Congress 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] The evaluation of a novel PET ligand for colony stimulating factor 1 receptor in status epilepticus model rat brains.2018
- Author(s)
  Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
- Organizer
  nnual Congress of the European Association of Nuclear Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] Development of PET imaging of Colony Stimulating Factor 1 Receptor Expressed on Microglia.2018
- Author(s)
  Ogata A, Kimura Y, Yamada T, Bin Ji, Seki C, Ichise M, Abe J, Ikenuma H, Koyama H, Suzuki M, Kato T, Ito K
- Organizer
  The XII International Symposium of Functional Neuroreceptor Mapping of the Living Brain
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02776
[Presentation] Synthesis of highly-qualified 11C-labeled (R,S)-isoproterenol aimed at a clinical study2017
- Author(s)
  Ikenuma H, Koyama H, Kimura Y, Abe J, Kawasumi K, Ogata A, Kato T, Ito K, Suzuki M.
- Organizer
  The 12th Asia Oceania Congress of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] 臨床研究を目的とした11C標識化(R,S)-イソプロテレノールの高効率合成法の開発2017
- Author(s)
  池沼　宏、古山浩子、木村泰之、阿部潤一郎、川角保広、小縣　綾、加藤隆司、伊藤健吾、鈴木正昭
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] 認知症治療薬としてのイソプロテレノールの小動物PETを用いたラット脳内移行性の検討2017
- Author(s)
  小縣　綾、木村泰之、池沼　宏、古山浩子、関千江、山田貴史、鈴木正昭、加藤隆司、伊藤健吾
- Organizer
  第57回日本核医学会学術総会
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] Brain penetration of isoproterenol as a drug of dementia measured in rats with a micro-PET2017
- Author(s)
  Ogata A, Kimura Y, Ikenuma H, Koyama H, Seki C, Yamada T, Suzuki M, Kato T, Ito K.
- Organizer
  The 12th Asia Oceania Congress of Nuclear Medicine and Biology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H04269
[Presentation] Evaluation of TlOH Effects for Pd0-Mediated Cross-Coupling of Methyl Iodide and Excess Boronic Acid Esters toward 11C-Incorporated PET Tracer Synthesis2015
- Author(s)
  Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
- Organizer
  PACIFICHEM 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460147
[Presentation] Evaluation of TlOH Effects for Pd0-Mediated Cross-Coupling of Methyl Iodide and Excess Boronic Acid Esters toward 11C-Incorporated PET Tracer Synthesis, Research area (10) Bench to Bedside2015
- Author(s)
  Hiroko Koyama, Hisashi Doi, Masaaki Suzuki
- Organizer
  The International Chemical Congress of Pacific Basin Societies 2015
- Place of Presentation
  Honolulu, Hawaii, USA
- Year and Date
  2015-12-15
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25242070
[Presentation] Synthesis of Disease Oriented and Novel PET Probe by Revolutionarily 11C Labeling Method
- Author(s)
  Hiroko Koyama
- Organizer
  Japan-China Nuclear Medicine Joint Symposium in Okinawa
- Place of Presentation
  Mercure Hotel Okinawa, Naha
- Year and Date
  2015-03-14 – 2015-03-15
- Invited
- Data Source
  KAKENHI-PROJECT-25460147

1. SUZUKI Masaaki (90093046)

# of Collaborated Projects: 6 results

# of Collaborated Products: 14 results
2. NATSUME Atsushi (30362255)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
3. WAKABAYASHI Toshihiko (50220835)

# of Collaborated Projects: 3 results

# of Collaborated Products: 4 results
4. ISHII Hideki (80425610)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. 木村泰之 (20423171)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
6. 加藤隆司 (60242864)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
7. 小縣綾 (10805857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KONDO Yutaka (00419897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. TAKEUCHI Ichiro (40335146)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YANAGAWA Hiroshi (40327672)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. DOI Hisashi (00421818)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
12. UMEMURA Kazuo (40232912)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. IJUIN Ryosuke (40442925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 伊藤健吾 (70184653)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
15. 関千江 (40443080)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
16. 山田貴史 (50531860)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. 鈴木啓介 (70635408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
18. 池沼宏 (10751159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 鈴木弘美 (30340269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
20. 季斌 (80392223)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
21. 外山宏 (90247643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. Soeda Yoshiyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. Sumioka Akio

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 近藤恭光

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
25. 高島明彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
26. 宮坂知宏

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Koyama Hiroko 古山 浩子

古山 浩子 コヤマ ヒロコ

KOYAMA Hiroko 古山 浩子

Research Projects

Research Products

Co-Researchers

Synthesis of 11C-labeled acyclic retinoids with high brain permeabilityPrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PET imaging of microglia, a novel drug target for neurodegenerative diseasesOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

PET microdose study for finding appropriate dose of isoproterenol as a disease modifying treatment of dementiaOngoing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of PET probes of neuroprotective molecular components in oriental medicines

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of rapid C-methylation between two sp3-hybridized carbons for incorporation of short-lived positron-emitting 11C radionuclidePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Multimodal medical strategies by means of robotic technology according with molecular target imaging

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Synthesis of glycosylated derivatives of ginkgolides and in vivo evaluation of those pharmacokinetics

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Chemical biology reprogramming epigenetic aberration in malignant brain tumors

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of molecular imaging tracers for anticancer drug resistant proteins

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residue with 1,2-dihydroxybenzene groups2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Pd0-mediated rapid cross-coupling reactions, the rapid C-[11C]methylations, revolutionarily advancing the syntheses of short-lived PET molecular probes2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Efficient syntheses of [11C]zidovudine and its analogs by convenient one-pot palladium(0)-copper(I) co-mediated rapid C-[11C]methylation2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Synthesis of 11C-labeled retinoic acid, [11C]ATRA, via an alkenylboron precursor by Pd(0)-mediated rapid C-[11C]methylation.2014

Author(s)

Journal Title

DOI

Data Source

Koyama Hiroko 古山浩子

古山浩子コヤマヒロコ

KOYAMA Hiroko 古山浩子