Nishikimi Akihiko 錦見昭彦

… Alternative Names

NISHIKIMI Nishikimi 錦見昭彦

NISHIKIMI Akihiko 錦見昭彦

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Researcher Number	70404019
Other IDs	https://orcid.org/0000-0001-9497-7557
Affiliation (Current)	2025: 国立研究開発法人国立長寿医療研究センター, 研究所研究推進基盤センター, 室長
Affiliation (based on the past Project Information) *help	2022 – 2024: 国立研究開発法人国立長寿医療研究センター, 研究所研究推進基盤センター, 室長 2021: 国立研究開発法人国立長寿医療研究センター, 研究推進基盤センター, 室長 2019 – 2020: 国立研究開発法人国立長寿医療研究センター, バイオセーフティ管理・研究室, 室長 2013 – 2016: 北里大学, 理学部, 准教授 2010 – 2012: 九州大学, 生体防御医学研究所, 助教 2007 – 2008: Kyushu University, Medical Institute of Bioregulation, Assistant Professor 2006: 九州大学, 生体防御医学研究所, 助手
Review Section/Research Field	Principal Investigator Immunology / Biological Sciences / Basic Section 59040:Nutrition science and health science-related / Basic Section 43030:Functional biochemistry-related Except Principal Investigator Biological Sciences / Medium-sized Section 52:General internal medicine and related fields / Basic Section 59040:Nutrition science and health science-related / Immunology / Functional biochemistry
Keywords	Principal Investigator シグナル伝達 / 細胞骨格 / 好中球 / キナーゼ / 感染防御 / 低分子化合物 / Rac / 炎症 / 細胞遊走 / 細胞 … More / 老化 / プロテオミクス解析 / コラーゲンペプチド / 水酸化プロリン / ペプチド / オリゴペプチド / コラーゲン / filamin / ケモアトラクタント / 接着 / 蛋白質 / 免疫学 / 細胞運動 / インテグリン / リンパ球 / 免疫シナプス / 分化 / 免疫応答 / 抗体産生 / 抗原応答 / B細胞 / 形態変化 / マクロピノサイトーシス / 低分子量Gタンパク質 / 貪食 / 活性酸素 / 脂質 / グアニンヌクレオチド交換因子(GEF) / ホスホリパーゼD / ホスファチジン酸 / アクチン重合 / 細胞極性 / リン脂質 / 極性 / 遊走 … More Except Principal Investigator Rac / DOCK2 / 樹状細胞 / シグナル伝達 / IEDDA / 細胞トラッキング / 生体直交反応 / 陽電子断層撮像法 / クロマチン・エピゲノム解析 / 免疫記憶 / 老化リンパ球 / 免疫老化 / 個体老化 / development・differentiation / allerev・asthma / biomolecule / signal transduction / Immunology / 細胞内動態 / ケモカイン / 遊走 / 発生・分化 / アレルギー・ぜんそく / 生体分子 / 免疫学 / 血管内皮細胞 / 器官形成 / 遺伝子改変マウス / 細胞運動 / 細胞情報伝達機構 / 小胞輸送 / アレルギー / サイトカイン受容体 / タンパク質分解 / 活性化 / タンパク分解 / ヘルパーT細胞 / 形質細胞樣樹状細胞 / Nef / T細胞 / HIV Less

Development of preventive and therapeutic strategies for age-related chronic inflammation by targeting senescence-associated T cellsPrincipal Investigator
- Principal Investigator
  
  錦見昭彦
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
Development of an in vivo cell tracking method using biological orthogonal reactions and PET
- Principal Investigator
  
  木村泰之
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 52:General internal medicine and related fields
- Research Institution
  National Center for Geriatrics and Gerontology
老化リンパ球による免疫制御機構の解明と賦活化方法の開発
- Principal Investigator
  
  丸山光生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  National Center for Geriatrics and Gerontology
The mechanism of action of collagen-derived oligopeptides on cell differentiation and proliferationPrincipal Investigator
- Principal Investigator
  
  Nishikimi Akihiko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  National Center for Geriatrics and Gerontology
免疫細胞におけるインテグリン動態制御マシナリーの解明Principal Investigator
- Principal Investigator
  
  錦見昭彦
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kitasato University
Role of DOCK2 in antigen-specific humoral immunityPrincipal Investigator
- Principal Investigator
  
  Nishikimi Akihiko
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Immunology
- Research Institution
  Kitasato University
  Kyushu University
好中球細胞外トラップに起因する炎症発症機構の解明と制御方法の開発Principal Investigator
- Principal Investigator
  
  錦見昭彦
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Signaling and functions of CDM family proteins that acts as Rac GEFs
- Principal Investigator
  
  FUKUI Yoshinori
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University
Molecular mechanism of neutrophil phagocytosis mediated by DOCK2 and Rac signalingPrincipal Investigator
- Principal Investigator
  
  NISHIKIMI Aklhiko
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
HIV NefによるT細胞機能異常における宿主シグナル伝達分子DOCK2の役割
- Principal Investigator
  
  FUKUI Yoshinori
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
免疫応答の質的制御に関わるサイトカイン受容体のタンパク質分解機構の解明
- Principal Investigator
  
  福井宣規
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular mechanisms of DOCK2 dynamics and cellpoIarization during neutrophil migrationPrincipal Investigator
- Principal Investigator
  
  NISHIKIMI Akihiko
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University
The role of DOCK2 and its regulatory mechanism in the innate immune system
- Principal Investigator
  
  FUKUI Yoshinori
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Immunology
- Research Institution
  Kyushu University

[Journal Article] A senolytic immunotoxin eliminates p16-positive T cells and ameliorates age-associated phenotypes of CD4+ T cells in a surface marker knock-in mouse2023
- Author(s)
  Sugiyama Yuma、Harada Tanenobu、Kamei Yuka、Yasuda Tomoharu、Mashimo Tomoji、Nishikimi Akihiko、Maruyama Mitsuo
- Journal Title
  
  Experimental Gerontology
  
  Volume: 174 Pages: 112130-112130
- DOI
  10.1016/j.exger.2023.112130
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K17820, KAKENHI-PROJECT-18KK0307, KAKENHI-PROJECT-23K24781, KAKENHI-PROJECT-21H02751
[Journal Article] The immunosenescence-related factor DOCK11 is involved in secondary immune responses of B cells2022
- Author(s)
  Sugiyama Y, Fujiwara M, Sakamoto A, Tsushima H, Nishikimi A, Maruyama M
- Journal Title
  
  Immun Aging
  
  Volume: 19 Issue: 1 Pages: 2-2
- DOI
  10.1186/s12979-021-00259-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06569
[Journal Article] Cul5-type Ubiquitin Ligase KLHDC1 Contributes to the Elimination of Truncated SELENOS Produced by Failed UGA/Sec Decoding2020
- Author(s)
  Okumura Fumihiko、Fujiki Yuha、Oki Nodoka、Osaki Kana、Nishikimi Akihiko、Fukui Yoshinori、Nakatsukasa Kunio、Kamura Takumi
- Journal Title
  
  iScience
  
  Volume: 23 Issue: 3 Pages: 100970-100970
- DOI
  10.1016/j.isci.2020.100970
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K06213, KAKENHI-PROJECT-19K06569, KAKENHI-PUBLICLY-19H04957, KAKENHI-PROJECT-17H03652, KAKENHI-PROJECT-18K19306, KAKENHI-PROJECT-19H00983, KAKENHI-PROJECT-19H02923
[Journal Article] Phosphatidic acid regulates subcellular distribution of RA-GEFs critical for chemokine-dependent migration2020
- Author(s)
  Momoi Yasuyuki、Nishikimi Akihiko、Du Guangwei、Kataoka Tohru、Katagiri Koko
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 524 Issue: 2 Pages: 325-331
- DOI
  10.1016/j.bbrc.2020.01.080
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06569, KAKENHI-PROJECT-19K07612
[Journal Article] Parallel Regulation of von Hippel-Lindau Disease by pVHL-Mediated Degradation of B-Myb and Hypoxia-Inducible Factor α.2016
- Author(s)
  Okumura F, Uematsu K, Byrne SD, Hirano M, Joo-Okumura A, Nishikimi A, Shuin T, Fukui Y, Nakatsukasa K, Kamura T.
- Journal Title
  
  Molecular Cellular Biology
  
  Volume: 36 Issue: 12 Pages: 1803-1817
- DOI
  10.1128/mcb.00067-16
- NAID
  120005844088
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01330, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PLANNED-24112006, KAKENHI-PROJECT-16H02497, KAKENHI-PROJECT-13J40160, KAKENHI-PROJECT-15K14474, KAKENHI-PROJECT-15K18503, KAKENHI-PROJECT-15K21056
[Journal Article] ASB7 regulates spindle dynamics and genome integrity by targeting DDA3 for proteasomal degradation.2016
- Author(s)
  Uematsu K, Okumura F, Tonogai S, Joo-Okumura A, Alemayehu DH, Nishikimi A, Fukui Y, Nakatsukasa K, Kamura T.
- Journal Title
  
  Journal of Cell Biology
  
  Volume: 215 Issue: 1 Pages: 95-106
- DOI
  10.1083/jcb.201603062
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01330, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24112006, KAKENHI-PROJECT-15K14474, KAKENHI-PROJECT-15K18503
[Journal Article] Dual functions of Rap1 are crucial for T-cell homeostasis and prevention of spontaneous colitis.2015
- Author(s)
  Ishihara S, Nishikimi A, Umemoto E, Miyasaka M, Saegusa M, Katagiri K
- Journal Title
  
  Nature Communications
  
  Volume: 6 Issue: 1 Pages: 8982-8982
- DOI
  10.1038/ncomms9982
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01330, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111005, KAKENHI-PROJECT-24590586
[Journal Article] DOCK5 functions as a key signaling adaptor that links FcεRI signals to microtubule dynamics during mast cell degranulation.2014
- Author(s)
  Ogawa K, Tanaka Y, Uruno T, Duan X, Harada Y, et al.
- Journal Title
  
  J. Exp. Med.
  
  Volume: (In press) Issue: 7 Pages: 1407-1419
- DOI
  10.1084/jem.20131926
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-13J03868, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590586, KAKENHI-PUBLICLY-25111508, KAKENHI-PROJECT-25251015, KAKENHI-PROJECT-26293393, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-26670287, KAKENHI-PROJECT-26670822, KAKENHI-PROJECT-26860332, KAKENHI-PROJECT-26870420
[Journal Article] DOCK2 and DOCK5 act additively in neutrophils to regulate chemotaxis, superoxide production, and extracellular trap formation.2014
- Author(s)
  Watanabe M, Terasawa M, Miyano K, Yanagihara T, Uruno T, Sanematsu F, Nishikimi A, Cote JF, Sumimoto H, Fukui Y.
- Journal Title
  
  J Immunol.
  
  Volume: 193 Issue: 11 Pages: 5660-5667
- DOI
  10.4049/jimmunol.1400885
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-25251015, KAKENHI-PLANNED-26111009, KAKENHI-PROJECT-26430115, KAKENHI-PROJECT-26670287, KAKENHI-PROJECT-26870420
[Journal Article] Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking.2014
- Author(s)
  Nishikimi A, Ishihara S, Ozawa M, Etoh K, Fukuda M, Kinashi T and Katagiri K
- Journal Title
  
  Sci. Signal.
  
  Volume: Vol. 7,　Issue 336 Issue: 336
- DOI
  10.1126/scisignal.2005199
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-ORGANIZER-22111001, KAKENHI-PLANNED-22111003, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-24590588, KAKENHI-PUBLICLY-25111509, KAKENHI-PROJECT-25291047
[Journal Article] The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway2013
- Author(s)
  Kamakura S., Nomura M., Hayase J., Iwakiri Y., Nishikimi A., Fukui Y., Takayanagi R., Sumimoto H.
- Journal Title
  
  Dev Cell
  
  Volume: 26 Issue: 3 Pages: 292-302
- DOI
  10.1016/j.devcel.2013.06.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21229002, KAKENHI-PROJECT-23591356, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590385, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-25251015
[Journal Article] Phosphatidic acid-dependent recruitment and function of the Rac activator DOCK1 during dorsal ruffle formation.2013
- Author(s)
  Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Cote JF, Fukui Y
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Issue: 12 Pages: 8092-8100
- DOI
  10.1074/jbc.m112.410423
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017, KAKENHI-ORGANIZER-24111001, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-24770127, KAKENHI-PROJECT-24890028, KAKENHI-PLANNED-24111007
[Journal Article] The Rac activator DOCK2 regulates natural killer cell-mediated cytotoxicity in mice through the lytic synapse formation2013
- Author(s)
  Sakai Y, Tanaka Y, Yanagihara T, Watanabe M, Duan X, Terasawa M, Nishikimi A, Sanematsu F, Fukui Y.
- Journal Title
  
  Blood
  
  Volume: 122 Issue: 3 Pages: 386-393
- DOI
  10.1182/blood-2012-12-475897
- Peer Reviewed
- Data Source
  KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-24770127, KAKENHI-PUBLICLY-25111508, KAKENHI-PROJECT-25251015
[Journal Article] Immune regulatory functions of DOCK family proteins in health and disease2013
- Author(s)
  Nishikimi A et al.
- Journal Title
  
  Exp. Cell. Res.
  
  Volume: 319 Issue: 15 Pages: 2343-2349
- DOI
  10.1016/j.yexcr.2013.07.024
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-24111007, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-25251015
[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK22012
- Author(s)
  Nishikimi A, et al
- Journal Title
  
  Chem.Biol.
  
  Volume: (In press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017
[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK22012
- Author(s)
  Nishikimi A, et al
- Journal Title
  
  Chem.Biol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790469
[Journal Article] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migrataon during immune responses2012
- Author(s)
  Yosuke Harada, Yoshihiko Tanaka, Masao Terasawa, Markus Pieczyk, Katsuyoshi Habiro, Tomoya Katakai, Kyoko Hanawa-Suetsugu, Mutsuko Kukimoto-Niino, Tomoko Nishizaki, Mikako Shirouzu, Xuefeng Duan, Takehito Uruno, Akihiko Nishikimi, Fumiyuki Sanematsu, Shigeyuki Yokoyama, Jens V.Stein, Tatsuo Kinashi, Yoshinori Fukui
- Journal Title
  
  Blood
  
  Volume: (In press) Issue: 19 Pages: 4451-4461
- DOI
  10.1182/blood-2012-01-407098
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22111003, KAKENHI-PUBLICLY-22117512, KAKENHI-PROJECT-22247017, KAKENHI-PROJECT-22370072, KAKENHI-PROJECT-22790469, KAKENHI-PUBLICLY-23111522, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-24770127, KAKENHI-PLANNED-22133009, KAKENHI-PUBLICLY-23113517, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007
[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK22012
- Author(s)
  Nishikimi A
- Journal Title
  
  Chem. Biol.
  
  Volume: 19 Pages: 488-497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017
[Journal Article] Next-generation sequencing coupled with a cell-free display technology for high-throughput production of reliable interactome data2012
- Author(s)
  Fujimori S
- Journal Title
  
  Scientific Reports
  
  Volume: 2 Issue: 1 Pages: 1-5
- DOI
  10.1038/srep00691
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017, KAKENHI-PUBLICLY-23134510, KAKENHI-PROJECT-23651190, KAKENHI-PROJECT-24590586, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007
[Journal Article] Structural basis for mutual relief of the Rac guanine nucleotide exchange factor DOCK2 and its partner ELMO1 from their autoinhibited forms.2012
- Author(s)
  Hanawa-Suetsugu K, Kukimoto-Niino M, Mishima-Tsumagari C, Akasaka R, Ohsawa N, Sekine S, Ito T, Tochio N, Koshiba S, Kigawa T, Terada T, Shirouzu M, Nishikimi A, Uruno T, Katakai T, Kinashi T, Kohda D, Fukui Y, Yokoyama S
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 109 Issue: 9 Pages: 3305-3310
- DOI
  10.1073/pnas.1113512109
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017, KAKENHI-PROJECT-22790469, KAKENHI-PUBLICLY-23113517, KAKENHI-ORGANIZER-24111001
[Journal Article] Fukui, Y. DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses2012
- Author(s)
  Y., Tanaka, Y., Terasawa, M., Pieczyk, M., Habiro, K., Katakai, T., Hanawa-Suetsugu, K., Kukimoto-Niino, M., Nishizaki, T., Shirouzu, M., Duan, X., Uruno, T., Nishikimi, A., Sanematsu, F., Yokoyama, S., Stein, J. V., Kinashi, T., Fukui, Y.
- Journal Title
  
  Blood
  
  Volume: 119 Pages: 4451-4461
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790469
[Journal Article] Dimerization of DOCK2 is essential for DOCK2-mediated Rac activation and lymphocyte migration2012
- Author(s)
  Terasawa M, Uruno T, Mori S, Kukimoto-Niino M, Nishikimi A, Sanematsu F, Tanaka Y, Yokoyama S, Fukui Y
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 9 Pages: e46277-e46277
- DOI
  10.1371/journal.pone.0046277
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017, KAKENHI-PUBLICLY-23111522, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-24770127, KAKENHI-ORGANIZER-24111001, KAKENHI-PLANNED-24111007
[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activatorDOCK22012
- Author(s)
  Nishikimi A, Uruno T, Duan X, Cao Q, Okamura Y, Saitoh T, Saitoh N, Sakaoka S, Du Y, Suenaga A, Kukimoto-Niino M, Miyano K, Gotoh K, Okabe T, Sanematsu F, Tanaka Y, Sumimoto H., Honma T, Yokoyama S, Nagano T, Kohda D, Kanai M, and Fukui Y
- Journal Title
  
  Chem. Biol
  
  Volume: 19 Issue: 4 Pages: 488-497
- DOI
  10.1016/j.chembiol.2012.03.008
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-20117002, KAKENHI-PROJECT-22247017, KAKENHI-PUBLICLY-23111522, KAKENHI-PROJECT-23790338, KAKENHI-PROJECT-24590586, KAKENHI-PROJECT-24770127, KAKENHI-ORGANIZER-24111001
[Journal Article] Structural basis for mutual relief of DOCK2 and ELMO1 from their autoinhibited forms for Rac activation in lymphocyte chemotaxis2012
- Author(s)
  Hanawa-Suetsugu, K., Kukimoto-Niino, M., Mishima-Tsumagari, C., Akasaka, R., Ohsawa, N., Sekine, S., Ito, T., Tochio, N., Koshiba, S., Kigawa, T., Terada, T., Shirouzu, M., Nishikimi, A., Uruno, T., Katakai, T., Kinashi, T., Kohda, D., Fukui, Y., Yokoyama
- Journal Title
  
  Proc. Natl. Acad. Sci.USA
  
  Volume: 109 Pages: 3305-3310
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790469
[Journal Article] Blockade of inflammatory responses by a small-molecule inhibitor of the Racactivator DOCK22012
- Author(s)
  Nishikimi A, et al
- Journal Title
  
  Chem.Biol.
  
  Volume: (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-22117512
[Journal Article] Fukui, Y. Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK22012
- Author(s)
  Nishikimi A., Uruno, T., Duan, X., Cao, Q., Okamura, Y., Saitoh, T., Saito, N., Sakaoka, S., Du, Y., Suenaga, A., Kukimoto-Niino, M., Miyano, K., Gotoh, K., Okabe, T., Sanematsu, F., Tanaka, Y., Sumimoto, H., Honma, T., Yokoyama, S., Nagano, T., Kohda, D., Kanai, M., Fukui, Y.
- Journal Title
  
  Chem. Biol
  
  Volume: 19 Pages: 488-497
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790469
[Journal Article] DOCK180 is a Rac activator that regulates cardiovascular development by acting downstream of CXCR4.2010
- Author(s)
  Sanematsu F, Hirashima M, Laurin M, Takii R, Nishikimi A, Kitajima K, Ding G, Noda M, Murata Y, Tanaka Y, Masuko S, Suda T, Meno C, Cote JF, Nagasawa T, Fukui Y
- Journal Title
  
  Circ. Res.
  
  Volume: 107 Issue: 9 Pages: 1102-1105
- DOI
  10.1161/circresaha.110.223388
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22247017
[Journal Article] Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation2010
- Author(s)
  Fukui Y(著者17名、17番目)
- Journal Title
  
  J. Exp. Med.
  
  Volume: 207 Issue: 4 Pages: 721-730
- DOI
  10.1084/jem.20091776
- NAID
  40019145306
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-19059004, KAKENHI-PROJECT-22247017, KAKENHI-PROJECT-22590444
[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
- Author(s)
  Nishikimi A., et.al.
- Journal Title
  
  Science (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19044030
[Journal Article] Frohman MA, Fukui Y Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
- Author(s)
  Nishikimi A, Fukuhara H, Su W, Hongu T, Takasuga S, Mihara H, Cao Q, Sanematsu F, Kanai M, Hasegawa H, Tanaka Y, Shibasaki M, Kanaho Y, Sasaki T, Frohman MA
- Journal Title
  
  Science 324
  
  Pages: 381-384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790362
[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
- Author(s)
  Nishikimi A, et.al.
- Journal Title
  
  Science (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790362
[Journal Article] Sequential regulation of DOCK2 dynamics by two phospholipids during neutrophil chemotaxis2009
- Author(s)
  Nishikimi A., et.al.
- Journal Title
  
  Science (印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19041054
[Journal Article] Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendrtic cells.2008
- Author(s)
  Gotoh, K, Tanaka, Y, Nishikimi, A, et. al.
- Journal Title
  
  Blood 111
  
  Pages: 2973-2976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790362
[Journal Article] Differential requirement for DOCK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells2008
- Author(s)
  Gotoh K, Tanaka Y, Nishikimi A, Inayoshi A, Enjoji M, Takayanagi R, Sasazuki T, Fukui Y
- Journal Title
  
  Blood 111
  
  Pages: 2973-2976
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790362
[Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2.2007
- Author(s)
  Tanaka, Y, Harnano, S, Gotoh, K, Murata, Y, Kunisaki, Y, Nishikimi, A, et. al.
- Journal Title
  
  Nature Immunology 8
  
  Pages: 1067-1075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790362
[Journal Article] T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Racactivator Dock22007
- Author(s)
  Tanaka Y, Hamano S, Gotoh K, Murata Y,Kunisaki Y, Nishikimi A, Takii R, KawaguchiM, Inayoshi A, Masuko S, Himeno K, Sasazuki T, Fukui Y
- Journal Title
  
  Nat. Immunol 8
  
  Pages: 1067-1075
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19790362
[Patent] DOCK2によるRac活性化を制御する低分子化合物及びその用途2011
- Inventor(s)
  福井宣規, 錦見昭彦, 金井求, 神田大輔, 齋藤貴士
- Industrial Property Rights Holder
  九州大学, 東京大学
- Industrial Property Number
  2011-109334
- Filing Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-22790469
[Patent] DOCK2によるRac活性化を制御する低分子化合物及びその用途2011
- Inventor(s)
  福井宣規, 錦見昭彦, 金井求, 神田大輔, 齋藤貴土
- Industrial Property Rights Holder
  九州大学, 東京大学
- Industrial Property Number
  2011-109334
- Filing Date
  2011-05-16
- Data Source
  KAKENHI-PUBLICLY-22117512
[Patent] DOCK2によるRac活性化を制御する低分子化合物及びその用途2011
- Inventor(s)
  福井宣規、錦見昭彦、金井求、神田大輔、齋藤貴士
- Industrial Property Rights Holder
  九州大学、東京大学
- Filing Date
  2011-05-16
- Data Source
  KAKENHI-PROJECT-22790469
[Presentation] 新規老化細胞可視化マウスの作製と老化細胞における糖鎖の発現パターン2020
- Author(s)
  錦見昭彦、丸山光生
- Organizer
  第93回日本生化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06569
[Presentation] コラーゲン由来のペプチドによるCD4陽性T細胞分化の制御2019
- Author(s)
  錦見昭彦, 小山洋一, 楠畑雅, 服部俊治, 片桐晃子
- Organizer
  第92回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-19K06569
[Presentation] Rap1シグナルによる血管内皮上でのリンパ球の動態制御機構2017
- Author(s)
  錦見昭彦、石原沙耶花、片桐晃
- Organizer
  生体運動合同班会議2017
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2017-01-08
- Data Source
  KAKENHI-PUBLICLY-15H01330
[Presentation] Rap1とfilaminの相互作用を介したリンパ球の接着制御2016
- Author(s)
  錦見昭彦，石原沙耶花，片桐晃子
- Organizer
  生体運動合同班会議2016
- Place of Presentation
  キャンパスプラザ京都（京都府京都市）
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PUBLICLY-15H01330
[Presentation] Clathrin-dependent internalization of LFA-1 plays an important role in rear detachment during lymphocyte migration.2016
- Author(s)
  Nishikimi A, Ishihara S, Katagiri K.
- Organizer
  第45回日本免疫学会学術集会
- Place of Presentation
  沖縄コンベンションセンター（沖縄県宜野湾市）
- Year and Date
  2016-12-07
- Data Source
  KAKENHI-PUBLICLY-15H01330
[Presentation] Rap1とfilaminの相互作用を介したリンパ球の接着制御2016
- Author(s)
  錦見昭彦，石原沙耶花，片桐晃子
- Organizer
  生体運動合同班会議2016
- Place of Presentation
  キャンパスプラザ京都（京都府京都市）
- Year and Date
  2016-01-08
- Data Source
  KAKENHI-PROJECT-24590586
[Presentation] Rab13 is a downstream effector of Mst1 to mediate LFA-1 activation crucial for lymphocyte trafficking.2015
- Author(s)
  Nishikimi A, Ishiahra S, Katagiri K
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PUBLICLY-15H01330
[Presentation] Lymphocyte arrest was induced by the binding of active Rap1 to filamins.2015
- Author(s)
  Ishiahra S, Nishikimi A, Katagiri K
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PUBLICLY-15H01330
[Presentation] Lymphocyte arrest was induced by the binding of active Rap1 to filamins.2015
- Author(s)
  Ishiahra S, Nishikimi A, Katagiri K
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-24590586
[Presentation] Rab13 is a downstream effector of Mst1 to mediate LFA-1 activation crucial for lymphocyte trafficking.2015
- Author(s)
  Nishikimi A, Ishiahra S, Katagiri K
- Organizer
  第44回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-24590586
[Presentation] Rab13 is a downstream effector of Mst1 to mediate LFA-1 activation crucial for lymphocyte trafficking.2014
- Author(s)
  Nishikimi A, Ishihara S, Ozawa M, Kinashi T, Katagiri K.
- Organizer
  第43回日本免疫学会学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10
- Data Source
  KAKENHI-PROJECT-24590586
[Presentation] Dock8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.2013
- Author(s)
  Nishikimi A, Harada Y, Tanaka Y, Stein JV, Kinashi T, Fukui Y
- Organizer
  The 23rd CDB Meeting: Building multicellular systems from cellular cross-talk
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] Dock8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.2013
- Author(s)
  Nishikimi A et al
- Organizer
  The 23rd CDB Meeting Building multicellular systems from Cellular Cross-Talk
- Place of Presentation
  理化学研究所（神戸）
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.2013
- Author(s)
  Nishikimi, A., Harada, Y., Tanaka, Y., Terasawa, M., Stein, J.V., Kinashi, T., Fukui, Y.
- Organizer
  The 23rd CDB Meeting Building Multicellular Systems from Cellular Cross-Talk
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24590586
[Presentation] DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses.2012
- Author(s)
  Tanaka Y, Harada Y, Terasawa M, Nishikimi A, Kinashi T, Fukui Y
- Organizer
  第41回日本免疫学会学術集会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] Role of DOCK1 and its regulation during dorsal ruffle formation.2012
- Author(s)
  Sanematsu F, Nishikimi A, Watanabe M, Hongu T, Tanaka Y, Kanaho Y, Jean-Francois Cote, Fukui Y
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] 免疫系特異的なRac活性化因子DOCK2を標的とした免疫抑制剤の開発2012
- Author(s)
  錦見昭彦、田中芳彦、福井宣規
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  千葉
- Year and Date
  2012-11-27
- Data Source
  KAKENHI-PROJECT-22790469
[Presentation] A Role of phospholipid in DOCK family protein-mediated cellular functions.2011
- Author(s)
  Fukui Y, Sanematsu F, Nishikimi
- Organizer
  第10回日本生化学会JBSバイオフロンティアシンポジウム
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] 免疫特異的なRac活性化因子DOCK2を標的とした免疫抑制剤の開発2011
- Author(s)
  錦見昭彦, 他
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  幕張メッセ(千葉)
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] 免疫特異的なRac活性化因子DOCK2を標的とした免疫抑制剤の開発2011
- Author(s)
  錦見昭彦、田中芳彦、福井宣規
- Organizer
  第40回日本免疫学会学術集会
- Place of Presentation
  千葉
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PROJECT-22247017
[Presentation] 免疫系特異的なRac活性化因子DOCK2を標的とした免疫抑制剤の開発2011
- Author(s)
  錦見昭彦、田中芳彦、福井宣規
- Organizer
  第40回日本免疫学会総会・学術集会
- Place of Presentation
  千葉(招待講演)
- Year and Date
  2011-11-27
- Data Source
  KAKENHI-PUBLICLY-22117512
[Presentation] リン脂質を介したRac活性化分子DOCK2の時空間制御2009
- Author(s)
  錦見昭彦, 他
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19041054
[Presentation] リン脂質を介したRac活性化分子DOCK2の時空間制御2008
- Author(s)
  錦見昭彦, 他
- Organizer
  第31回日本分子生物学会年会・第81回日本生化学会大会・合同大会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19044030
[Presentation] 好中球におけるリン脂質を介したRac活性化分子DOCK2の時空間制御2008
- Author(s)
  錦見昭彦、田中芳彦、福井宣規
- Organizer
  第38回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2008-12-01
- Data Source
  KAKENHI-PROJECT-19790362
[Presentation] リン脂質を介したRac活性化分子DOCK2の時空間制御2008
- Author(s)
  錦見昭彦、福井宣規
- Organizer
  第31回日本分子生物学会年会、第81会日本生化学会大会合同大会(BMB2008)
- Place of Presentation
  神戸
- Year and Date
  2008-12-12
- Data Source
  KAKENHI-PROJECT-19790362
[Presentation] 好中球におけるリン脂質を介したRac活性分子DOCK2の時空間制御2008
- Author(s)
  錦見昭彦, 他
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19041054
[Presentation] 好中球におけるリン脂質を介したRac活性分子DOCK2の時空間制御2008
- Author(s)
  錦見昭彦, 他
- Organizer
  第38回日本免疫学会総会
- Place of Presentation
  京都
- Data Source
  KAKENHI-PROJECT-19044030
[Presentation] OCK2は好中球遊走において細胞運動および極性を制御する2007
- Author(s)
  錦見昭彦
- Organizer
  第17回 Kyoto T Cell Conference
- Place of Presentation
  京都
- Year and Date
  2007-06-16
- Data Source
  KAKENHI-PROJECT-19790362
[Presentation] DOCK2 is a Rac activator that regulates motility and polarity during neutronhil chemotaxis2006
- Author(s)
  Akihiko Nishikimi, et. al.
- Organizer
  日本分子生物学会2006フォーラム
- Place of Presentation
  名古屋
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390154
[Presentation] DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis2006
- Author(s)
  Nishikimi, A., et. al.
- Organizer
  MBSJ Forum 2006
- Place of Presentation
  Nagoya
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390154

1. FUKUI Yoshinori (60243961)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
2. TANAKA Yoshihiko (00398083)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
3. 實松史幸 (80381094)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. 大橋紹宏 (80835249)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 丸山光生 (00212225)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 木村泰之 (20423171)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 池沼宏 (10751159)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 小縣綾 (10805857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 今村真一 (40873203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 境崇行 (40881925)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 古山浩子 (50402160)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 加藤隆司 (60242864)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 杉山悠真

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 野村政壽

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 木梨達雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. 片貝智哉

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
17. 奥村文彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 渡辺武

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. 住本英樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nishikimi Akihiko 錦見 昭彦

NISHIKIMI Nishikimi 錦見 昭彦

NISHIKIMI Akihiko 錦見 昭彦

Research Projects

Research Products

Co-Researchers

Development of preventive and therapeutic strategies for age-related chronic inflammation by targeting senescence-associated T cellsPrincipal Investigator

Principal Investigator

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Research Institution

Development of an in vivo cell tracking method using biological orthogonal reactions and PET

Principal Investigator

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Review Section

Research Institution

老化リンパ球による免疫制御機構の解明と賦活化方法の開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The mechanism of action of collagen-derived oligopeptides on cell differentiation and proliferationPrincipal Investigator

Principal Investigator

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Review Section

Research Institution

免疫細胞におけるインテグリン動態制御マシナリーの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of DOCK2 in antigen-specific humoral immunityPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

好中球細胞外トラップに起因する炎症発症機構の解明と制御方法の開発Principal Investigator

Principal Investigator

Project Period (FY)

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Review Section

Research Institution

Signaling and functions of CDM family proteins that acts as Rac GEFs

Principal Investigator

Project Period (FY)

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Research Field

Research Institution

Molecular mechanism of neutrophil phagocytosis mediated by DOCK2 and Rac signalingPrincipal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

HIV NefによるT細胞機能異常における宿主シグナル伝達分子DOCK2の役割

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

免疫応答の質的制御に関わるサイトカイン受容体のタンパク質分解機構の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanisms of DOCK2 dynamics and cellpoIarization during neutrophil migrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The role of DOCK2 and its regulatory mechanism in the innate immune system

Principal Investigator

Nishikimi Akihiko 錦見昭彦

NISHIKIMI Nishikimi 錦見昭彦

NISHIKIMI Akihiko 錦見昭彦