YAMAMURA Hirohei 山村博平

Researcher Number	90030882
Affiliation (based on the past Project Information) *help	2006 – 2007: 神戸大学, 名誉教授 2005: 神戸大学, 大学院医学系研究科, 教授 2001 – 2005: 神戸大学, 大学院・医学系研究科, 教授 1994 – 2000: Kobe University School of Medicine Professor, 医学部, 教授 1986 – 1994: 福井医科大学, 医学部, 教授 1986: 福井医大, 医学部, 教授
Review Section/Research Field	Principal Investigator General medical chemistry / Pathological medical chemistry / Biological Sciences / Functional biochemistry / Pathological medical chemistry / General medical chemistry Except Principal Investigator General medical chemistry / Pathological medical chemistry / General medical chemistry / Radiation science
Keywords	Principal Investigator Syk / チロシンキナーゼ / Lyn / SH2 / ZAP-70 / 血小板 / Shc / protein-tyrosine kinase / 脾臓 / Cキナーゼ … More / DT40細胞 / 神経成長円錐 / チロシンホスファターゼ / Bリンパ球 / アポトーシス / 血管内皮細胞 / 細胞増殖 / p72syk / Protein-tyrosine kinase / DT-40 cell / CD45 / ポリアミン / Cキナ-ゼ / Src / K562細胞 / コルタクチン / TPA / Zap-70 / 巨核球 / 消去酵素 / バクテリア / 放線菌 / 癌 / 細胞移動 / アポトーシス細胞 / 白血病 / S6蛋白質 / プロテアーゼ / スロンビン / CSK / P72^<syk> / 細胞質チロシンキナ-ゼ / Ca^<2+> / Thrombin / PI3キナーゼ / PLCγ / トロンビン / Tyrosine kinase / SHP-2 / SHPS-1 / 酸化ストレス / Phospholipase D / Pak2 / Cbl / ubiquitination / 3BP2 / phagocytosis / lysosomes / 細胞骨格 / ポリ塩基性アミノ酸 / ブタ / 限定分解 / トリプシン様プロテア-ゼ / イオン強度 / pH / ヒストキナ-ゼ / GTP結合蛋白質 / PI3-kinase / Grb2 / small G蛋白質 / 神経組織 / 神経 / 発生・分化 / ZAP-70 family PTK / 遺伝子クローニング法 / 酵素活性 / ニトロセルロースフィルター / Denature-Renature / 接着分子 / 造血細胞分化 / 細胞外マトリックス / チロシンリン酸化 / 貪食 / 血漿 / GPI-PLD / 細胞貪食 / 血漿因子 / 血小板生成 / 微小管 / リソソーム / c-Ab1 / がん転移 / CXCL12 / 血球貪食症候群 / マクロファージ / Rab27A / HL60 / CMK / 自己認識機構 / 貪食受容体 / 糖原病 / ホスホリラーゼキナーゼ / 細胞膜 / 自動燐酸化反応 / 酸性燐脂質 / 蛋白質燐酸化反応 / 【Ca^(2+)】燐脂質依存性蛋白質燐酸化酵素(Cキナーゼ) / ホルボールエステル / 【Na^+】 / 【H^+】交換輸送系 / 制限消化 / 増殖因子 / Ca^<2+>-燐脂質依存性プロテインキナーゼ(Cキナーゼ) / Na^+ / H^+交換輸送系 / セリン・スレオニンキナーゼ / セリンキナーゼ / 細胞内情報伝達 / プロタミン / 燐酸化部位 / フルペイン / チロシンキナ-ゼ / バナジン酸 / セリンキナ-ゼ / ダウンレギュレ-ション / セロトニン放出反応 / tyrosine kinase / C-kinase / platelets / vanadate / serine kinase / spleen / thronbin / down-regulation / cDNAクローニング / p60^<src> / インスリン受容体 / PI-3キナーゼ / EGF受容体チロシンキナーゼ / p72^<syk> / 蛋白質チロシンホスファターゼ / CDNAクローニング / CDNAクロ-ニング / PI‐3キナ-ゼ / EGF受容体チロシンキナ-ゼ / 蛋白質チロシンホスファタ-ゼI / p60^<cーsrc> / p60^<cーyes> / PDGF受容体 / PIキナ-ゼ / EGF受容体 / 蛋白質チロシンホスファタ-ゼ / P60^<src> / EGF-receptor tyrosine kinase / cDNA cloning / Insulin-receptor kinase / PI-3 kinase / Protein-tyrosine phosphatase / H2Bヒストン / カルモジュリン / 蛋白質チロシン残基燐酸化酵素 / 蛋白質分解酵素 / 40Kチロシンキナ-ゼ / 自己燐酸化 / ミエリン塩基性蛋白質 / P72syk / Platelets / Calmodulin / Myosin light chain kinase / Wheat germ agglutinin / RBL-2H3細胞 / GAP / IgE受容体 / B細胞受容体 / B cell receptor / IgE receptor / FcgammaRIIIA / mast cell / インターロイキン2 / トロンボキサンA_2 / コンカナバリンA / 活性化機構 / PLCgamma / Interleukin2 / PI 3 kinase / Fyn / Csk / SHp-2 / パキシリン / SH-PTP2 / CSk / Trk / protein-tyrosine phosphatase / 過酸化水素 / 活性酸素 / ホスホリパーゼD / cortactin / oxidative stress / 肝臓細胞 / 神経系 / 血管平滑筋細胞 / チロシン燐酸化 / 血管 / 平滑筋細胞 / Protein-tyrosine / vascular endothelial cells / smooth muscle cells / neurons / tyrosine phosphorylated / non-hematopoietic cells / SyK / Bacteria / Apoptosis / B lymphocytes / Oxidative stress / アダプター蛋白質 / Cbl-b / c-Cbl / CRAM / 蛋白質リン酸化反応 / 蛋白質チロシンリン酸化反応 / 非受容体型チロシンキナーゼ / 細胞接着 / ユビチキン・プロテアソーム / がん / 感染症 / シグナル伝達 / 生体分子 / ファゴサイトーシス / 補体 / 発がん / 発がん抑制 / CXCR4 / 食作用 / Cancer / Infection / Signal transduction … More Except Principal Investigator チロシンキナーゼ / Syk / プロテインキナーゼC / 核局在化シグナル / ホスファチジルイノシトール3キナーゼ / 低分子量G蛋白質 / チオレドキシン / カルシウムイオン / 細胞増殖 / ホスホリパーゼC / ホスホリパーゼD / ADF / ホスホリパーゼA / ストレス / 機能探索分子 / Lyn / CRAM / CRMP-5 / Axon Pruning / Filopodia / RhoA / 細胞内情報伝達 / イオンチャネル / サイクリックAMP / リン酸化反応 / ネットワーク / 一酸化窒素 / キナーゼhCdsl / ダントロレン / カスバーゼ3 / TRAF6 / TAK1 / TAB2 / 蛋白質リン酸化 / カルシウムシグナリング / 細胞情報伝達 / セリン・スレオニンキナーゼ / 情報ネットワーク / キナーゼカスケード / 脂質メッセンジャー / ターゲッティング / PKN / CG-NAP / アミノ酸バランス / mTOR / 情報伝達機構網 / 構造解析 / 創薬 / PAF-アセチルヒドロラーゼ / PLD(ホスホリパーゼD) / PLC(ホスホリパーゼC) / PKC(プロテインキナーゼC) / 核-細胞質間物質輸送 / PI 3キナーゼ / Fas / NO(一酸化窒素) / 一酸化窒素合成酵素 / 神経伝達 / モノアミン / カルモデュリン依存性蛋白質リン酸化酵素 / Cキナーゼ / 蛋白質脱リン酸化酵素 / cDNAクローニング / 細胞周期 / 卵成熟 / 蛋白質燐酸化反応 / 蛋白質燐酸化酵素 / カゼインキナーゼII / プロゲステロン / ダウンレギュレーション / 蛋白質分解反応 / Cell cycle / Oocytes maturation / Protein phosphorylation / Protein kinase / Protein kinase C / Casein kinase II / Progesterone / Down regulation / 免疫系細胞(B細胞) / ジーンターゲッティング / Ca_<2+> / 血小板 / 細胞内移行 / 抗Syk抗体 / インテグリン / B細胞抗原レセプター / コラーゲンレセプター / PI3 kinase / トランスローケーション / p72syk / インターロイキン2 / protein-tyrosine kinase / B cell / Gene targeting / Calcium mobilization / platelets / Translocation / ホスホリパーゼ / Ras / 細胞分化 / エンドセリン / 受容体機能解析 / カルシウムシグナル / プロテインキナーゼ / 分子設計 / 有機合成 / 受容体 / プロスタグランジン / カルシウム / キナーゼ / 探索分子 / イメージング / 受容体の機能解析 / 情報分子の可視化 / 合成化合物 / セカンドメッセンジャー / 構造機能解析 / Receptor / Prostaglandin / Calciun / Kinese / Molecular Probe / Imagining / セマフォリン / セマホリン / Semaphorin / ファゴサイトーシス / 補体 / 細胞骨格 / 感染症 / 自然免疫 / 食作用 / C3bi / phagocytosis / tyrosine kinase / complement / cytoskeleton / infection / innate immunity / 細胞・組織 / 生体分子 / マクロファージ / 破骨細胞 / 微小管 / リソソーム / シグナル伝達 / Cell / Tissue / Bio molecule / Macrophage / Osteoclast / Microtubule / Lysosome / Tyrosine kinase / 心筋代謝 / 核医学 / ポジトロン断層法 / 代謝イメージング / 脂肪酸 / 脂肪酸代謝 / Myocardial Metabolism / Nuclear Medicine / Positron Emission Tomography / Metabolic Imaging Less

Elucidation of the osteolytic mechanism by osteoclasts
- Principal Investigator
  
  TOHYAMA Yumi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Himeji Dokkyo University
マクロファージが自己細胞を認識する機構とその破綻Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
チロシンキナーゼSykが発癌に抑制的に関わる分子機構の解明Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
Research of the novel role of SykPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
Research of the molecular mechanism of the phagocytosis in innate immunity
- Principal Investigator
  
  TOHYAMA Yumi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
血小板生成の謎に迫る-巨核球から血小板放出へ至る分子メカニズムの解明-Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Elucidation of molecular signaling mechanism of axonal guidance
- Principal Investigator
  
  YANAGI Shigeru
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
Research for regulation system and new function of tyrosine kinase SykPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
細胞増殖およびがんの形成過程におけるチロシンキナーゼSykの機能解析Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
細胞増殖およびがんの形成過程におけるチロシンキナーゼSykの機能解析Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
生体内のアポトーシス細胞除去を促進する新規血漿因子の同定Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
細胞内情報伝達機構網の研究
- Principal Investigator
  
  西塚泰美
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  Kobe University
Biological Functions and Designed Probe Compounds
- Principal Investigator
  
  SUZUKI Masaaki, 日高弘義
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gifu University
  Nagoya University
プロテインキナーゼを中心とする情報ネットワークの解析Principal Investigator
- Principal Investigator
  
  山村博平, 日高弘義
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Kobe University
  Nagoya University
チロシンキナーゼおよびホスファターゼによるBリンパ球分化機構Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Kobe University
バクテリアが生成するアポトーシス抑制因子の同定とそのメカニズムPrincipal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kobe University
Identification of apoptosis inhibitor produced by bacteria speciesPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
脳神経系に分布する新規SykファミリーチロシンキナーゼPrincipal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
脳神経系に分布する新規Sykファミッリーチロシンキナーゼの探索Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Kobe University
IDENTIFICATION AND CHARACTERIZATION OF Syk FAMIRY PROTEIN TYROSINE KINASEPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOBE UNIVERSITY
脳組織に分布する非受容体型チロシンキナーゼSykについてPrincipal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
転写膜上での酵素活性を指標とした直接遺伝子クローニング技術の開発Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kobe University
細胞質チロシンキナーゼp72^<syk>を介する細胞内情報伝達とG蛋白質Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
細胞の分化増殖における非受容体型チロシンキナーゼSykの関与Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
神経細胞におけるp72^<Syk>の存在とその機能Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kobe University
Study of signal transduction via an SH2 which recognizes phosphotyrosine residues of proteinsPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  KOBE UNIVERSITY
Molecular basis of pathophysiological role of Syk in blood and immumecellsPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOBE UNIVERSITY
蛋白質チロシンキナーゼp72^<Syk>を介する細胞内情報伝達とG蛋白質Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  福井医科大学
細胞内情報伝達機構網の研究
- Principal Investigator
  
  西塚泰美
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  Kobe University
細胞内情報伝達機構網の研究
- Principal Investigator
  
  西塚泰美
- Project Period (FY)
  1994 – 1998
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  Kobe University
細胞内情報伝達機構網の研究
- Principal Investigator
  
  西塚泰美
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  Kobe University
細胞内情報伝達機構網の研究
- Principal Investigator
  
  西塚泰美
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Creative Basic Research
- Research Institution
  Kobe University
Physiological role of protein-tyrosine kinase p72^<syk>Principal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kobe University
  福井医科大学
Physiological function of non-receptor type protein-tyrosine kinase p72^<syk>Principal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KOBE UNIBERSITY
  福井医科大学
Action of novel non-receptor type protein-tyrosine kinase, p72^<syk>in immune cells.
- Principal Investigator
  
  YANAGI Shigeru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukui Medical School
Role of protein kinase in cell cycle regulation
- Principal Investigator
  
  HASHIMOTO Eikichi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tottori University
  福井医科大学
Activation of cytosolic protein-tyrosine kinase and analysis of its substrate proteinsPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Fukui Medical School
Protein-tyrosine phosphorylation and its biological significancePrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukui Medical School
細胞の癌化における蛋白質燐酸化酵素の役割Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  福井医科大学
Ca^<2+>・燐脂質依存性蛋白質燐酸化酵素(Cキナ-ゼ)の基質認識についてPrincipal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  福井医科大学
Role of Protein-Tyrosine Kinases and Protein-Serine Kinases in Intracellular Signal TransductionPrincipal Investigator
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukui Medical School
細胞内情報伝達におけるチロシンキナーゼとセリン・スレオニンキナーゼに関する研究Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  福井医科大学
Ca^<2+>・燐脂質依存性蛋白質燐酸化酵素(Cキナーゼ)の基質認識についてPrincipal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  福井医科大学
カルシウムイオンによる物質代謝の調節機構
- Principal Investigator
  
  藤澤仁
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Asahikawa Medical College
細胞増殖因子の作用機構………特に蛋白質燐酸化酵素とプロテアーゼの関与についてPrincipal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  福井医科大学
糖原病の成因の解析Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  福井医科大学
細胞増殖における蛋白質燐酸化酵素の役割-特に蛋白質分解酵素に注目して-Principal Investigator
- Principal Investigator
  
  山村博平
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  福井医科大学
Studies on the development of measurments of fatty acid metabolism
- Principal Investigator
  
  TORIZUKA Kanji
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Radiation science
- Research Institution
  Fukui Medical School

All 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells.2007
- Author(s)
  Noda C, He J, Takano T, Tanaka C, Kondo T, Tohyama K, Yamamura H, Tohyama Y
- Journal Title
  
  Biochem Biophys Res Commun. 362
  
  Pages: 951-957
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590267
[Journal Article] Effects of peripheral cannabinoid receptor ligands on motility and polarization in neutrophil-like HL60 cells and human neutrophils.2006
- Author(s)
  Kurihara, R., Tohyama.Y., Matsusaka, S., Naruse, H., Kinoshita, E., Tsujioka, T., Katsumata, Y., Yamamura, H.
- Journal Title
  
  J.Biol.Chem. 281
  
  Pages: 12908-12918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590229
[Journal Article] Protein-tyrosine kinase, Syk is required for pathogen engulfment in complement-mediated phagocytosis.2006
- Author(s)
  Shi, Y., Tohyama, Y., Kadono, T., He, J., Miah, S.M.S., Hazama, R., Tanaka, C., Tohyama, K., Yamamura, H.
- Journal Title
  
  Blood (in Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Journal Article] Protein-tyrosine kinase, Syk is required for pathogen engulfment in complement-mediated phagocytosis.2006
- Author(s)
  Shi, Y., Tohyama, Y., Kadono, T., He, J., Miah, S.M.S., Hazama, R., Tanaka, C., Tohyama, K., Yamamura, H.
- Journal Title
  
  Blood (in Press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590229
[Journal Article] Complement-mediated-phagocytosis-the role of Syk.2006
- Author(s)
  Tohyama Y, Yamamura H
- Journal Title
  
  IUBMB Life. 58
  
  Pages: 304-308
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590267
[Journal Article] Protein-tyrosine kinase, Syk is required for pathogen engulfment in complement-mediated phagocytosis.2006
- Author(s)
  Shi Y, Tohyama Y, Kadono T, He J, Miah SMS, Hazama R, Tanaka C, Tohyama K, Yamamura H
- Journal Title
  
  Blood 107
  
  Pages: 4554-4562
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590267
[Journal Article] Effects of peripheral cannabinoid receptor ligands on motility and polarization neutrophil-like HL60 cells and human neutrophils.2006
- Author(s)
  Kurihara R, Tohyama Y, Matsusaka S, Kinoshita E, Naruse H, Tsujioka T, Katsumata Y, Yamamura H
- Journal Title
  
  J Biol Chem 281
  
  Pages: 12908-12918
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590267
[Journal Article] Lysosome is a primary organelle in B cell receptor-mediated apoptosis : an indispensable role of Syk in lysosomal function.2005
- Author(s)
  He, J., Tohyama, Y., Yamamoto, K., Kobayashi, M., Shi, Y., Takano, T., Noda, C., Tohyama, K., Yamamura, H.
- Journal Title
  
  Genes Cells. 10
  
  Pages: 23-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Journal Article] Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells.2005
- Author(s)
  Matsusaka, S., Tohyama, Y., He, J., Shi, Y., Hazama, R., Kadono, T., Kurihara, R., Tohyama, K., Yamamura, H.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 328
  
  Pages: 1163-1169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Journal Article] Lysosome is a primary organelle in B cell receptor-mediated apoptosis : an indispensable role of Syk in lysosomal function.2005
- Author(s)
  He, J., Tohyama Y., Yamamoto, K., Kobayashi, M., Shi, Y., Takano, T., Noda, C., Tohyama, K., Yamamura, H.
- Journal Title
  
  Genes Cells 10
  
  Pages: 23-35
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590229
[Journal Article] Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells.2005
- Author(s)
  Matsusaka, S., Tohyama.Y., He, J., Shi, Y., Hazama, R., Kadono, T., Kurihara, R., Tohyama, K., Yamamura, H.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 328
  
  Pages: 1163-1169
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590229
[Journal Article] B cell responses to oxidative stress.2004
- Author(s)
  Tohyama, Y., Takano, T., Yamamura, H.
- Journal Title
  
  Curr.Pharm.Des. 10
  
  Pages: 835-839
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Journal Article] Activation of Syk protein tyrosine kinase in response to osmotic stress requires interaction with p21-activated protein kinase Pak2γ-PAK.2004
- Author(s)
  Miah, S.M.S., Sada, K., Tuazon, P.T., Ling, J., Maeno, K., Kyo, S., Qu, X., Tohyama, Y., Traugh, J.A., Yamamura, H.
- Journal Title
  
  Mol.Cell.Biol. 24
  
  Pages: 71-83
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Journal Article] B cell responses to oxidative stress.2004
- Author(s)
  Tohyama, Y., Takano, T., Yamamura, H.
- Journal Title
  
  Curr.Pharm.Des. 10
  
  Pages: 835-839
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16590229
[Journal Article] Phosphorylation and recruitment of syk by immunoreceptor tyrosine-based activation motif-based phosphorylation of tamalin.2004
- Author(s)
  Hirose, M., Kitano, J., Nakajima, Y.Moriyoshi, K., Yanagi, S., Yamamura, H., Muto, T., Jingami, H., Nakanishi, S.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 32308-32315
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16390095
[Presentation] Protein-tyrosine kinase, Syk is essential for bone resorption through the regulation of lysosomal transport2007
- Author(s)
  Hazama, R, Tanaka, C, Hirohei Yamamura, H, Tohyama Y
- Organizer
  Joint Meeting of the Japanese Biochemical Society & the molecular Biology Sociaty of Japan
- Place of Presentation
  Yokohama
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590267
[Presentation] Protein-tyrosine kinase, Syk is required for bone resorbing activity by the mechanism of controlling the stability of tubulin2006
- Author(s)
  Tohyama Y, Qu X, Yamamura H
- Organizer
  20thIUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBB Congress
- Place of Presentation
  Kyoto
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18590267

1. YANAGI Shigeru (60252003)

# of Collaborated Projects: 19 results

# of Collaborated Products: 0 results
2. NAKAMURA Shunーichi (40155833)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. HASHIMOTO Eikichi (20116239)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
4. SADA Kiyonao (10273765)

# of Collaborated Projects: 8 results

# of Collaborated Products: 1 results
5. TOHYAMA Yumi (70362770)

# of Collaborated Projects: 7 results

# of Collaborated Products: 16 results
6. TANIGUCHI Takanobu (60217130)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
7. TAKANO Tomoko (30226807)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
8. TANAKA Yukie (10197486)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
9. 西塚泰美 (10025546)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
10. 横山光宏 (40135794)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
11. 淀井淳司 (80108993)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
12. 井上圭三 (30072937)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
13. YAMAMOTO Masashi (40134621)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. ONO Yoshitaka (10243297)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
15. INAZU Tetsuya (00242587)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
16. MINAMI Yasuhiro (70229772)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
17. 福井泰久 (00181248)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
18. 坂上庸一郎 (00187030)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
19. MARUYAMA Shingo (90262633)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. SUZUKI Masaaki (90093046)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. NOZAWA Yoshinori (10021362)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. TAKEDA Masao (40030853)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
23. 吉川潮 (40150354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. 日高弘義 (80100171)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
25. EBINA Yousuke (00112227)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. KASUGA Masato (50161047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. NAKAGAWA Hachirou (20029937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. OKADA Masato (10177058)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. MATOZAKI Takashi (80252782)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. IINO Masamitsu (50133939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. ICHIKAWA Atsushi (10025695)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. TORIZUKA Kanji (00025537)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. YONEKURA Yoshiharu (60135572)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. ISHII Yasushi (00026949)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. SUDO Masakatsu (10026867)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. NEGORO Hideo (90018903)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 田中千賀子 (20025571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 浅岡良則 (20222565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 松本邦弘 (70116375)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 遠藤實 (50009990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. 中西真 (40217774)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 米澤一仁 (70283900)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 斎藤尚亮 (60178499)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 深見泰夫 (00156746)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 向井秀幸 (80252758)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 米原伸 (00124503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. 藤澤仁 (10027039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. 宮本英七 (50109659)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. 藤田拓男 (30009964)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. 伊豆津公作 (50024617)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. 竹内郁登 (70262623)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 米田悦啓 (80191667)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 武藤多津郎 (60190857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
54. 野島庄七 (70090470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
55. 永井克孝 (80072974)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
56. KUROSAKI Tomohiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
57. KINET Jean-pierre

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
58. TOMOHIRO Kur

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

YAMAMURA Hirohei 山村 博平

Research Projects

Research Products

Co-Researchers

Elucidation of the osteolytic mechanism by osteoclasts

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マクロファージが自己細胞を認識する機構とその破綻Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

チロシンキナーゼSykが発癌に抑制的に関わる分子機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Research of the novel role of SykPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research of the molecular mechanism of the phagocytosis in innate immunity

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

血小板生成の謎に迫る-巨核球から血小板放出へ至る分子メカニズムの解明-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

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Research Institution

Elucidation of molecular signaling mechanism of axonal guidance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research for regulation system and new function of tyrosine kinase SykPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞増殖およびがんの形成過程におけるチロシンキナーゼSykの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

細胞増殖およびがんの形成過程におけるチロシンキナーゼSykの機能解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生体内のアポトーシス細胞除去を促進する新規血漿因子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞内情報伝達機構網の研究

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Biological Functions and Designed Probe Compounds

Principal Investigator

Project Period (FY)

Research Category

Research Institution

YAMAMURA Hirohei 山村博平