EBINA Yousuke 蛯名洋介

… Alternative Names

蝦名洋介エビナヨウスケ

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Researcher Number	00112227
Affiliation (based on the past Project Information) *help	2009 – 2012: The University of Tokushima, 疾患酵素学研究センター, 教授 2008: The University of Tokushima, 疾患酵素研究センター, 教授 2007: The University of Tokushima, Institute for Enzyme Research, Professor 1997 – 2006: The University of Tokushima, Institute for Enzyme Research, Professor, 分子酵素学研究センター, 教授 2005: 徳島大学, 分子酵素学研究センター, 助教授 … More 1988 – 1997: Tokushima Univ. Professor, 酵素科学研究センター, 教授 1990 – 1992: 徳島大学, 酵素研, 教授 1991: 徳島大学, 酸素科学センター, 教授 1989: 徳島大学, 酵素工学研究センター, 教授 1989: 徳島大学, 酵素科学センター, 教授 1989: 徳島大学酵素科学研究センター, 教授 1988: 徳島大学, 医学部, 教授 1988: 徳島大学, 酵素化学研究センター, 教授 1988: 徳島大学, 酵素研究センター, 教授 1986 – 1988: 熊本大学, 医学部, 助教授 1986: 熊本大, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / Pathological medical chemistry / General medical chemistry / Functional biochemistry / Biological Sciences / Structural biochemistry Except Principal Investigator Pathological medical chemistry / General medical chemistry / 内分泌・代謝学 … More / Pathological medical chemistry / General medical chemistry / Structural biochemistry / Sports science / Structural biochemistry / Biological Sciences Less
Keywords	Principal Investigator 糖尿病 / インスリン / シグナル伝達 / グルコーストランスポーター / インスリン作用 / インスリンシグナル伝達 / GLUT4トランスロケーション / インスリン受容体 / GLUT4 / トランスロケーション … More / グルコース取り込み / トランスジェニックマウス / PI3-キナーゼ / インスリンレセプター / インスリンレセプタ- / APS / GLUT4 translocation / PDGF / チロシンキナーゼ / diabetes / glucose uptake / Insulin signal transduction / プロテオーム解析 / NIDDM / 三量体Gタンパク / 遺伝子工学 / PIー3キナ-ゼ / ヒトインスリンレセプタ- / 細胞増殖 / AS160 / insulin receptor / internalization / Insulin signalling / Gq / Type 2 diabetes / Akt / Aktキナーゼ / 糖尿病薬 / Insulin action / PI3-kinase / Insulin Receptor / インスリンレセプタ-遺伝子異常 / 血中マーカー / 糖毒性 / インスリン受容体遺伝子 / II型糖尿病 / ポリモルフィズム / 血糖値降下 / ARF6 / グルコ-ストランスポ-タ- / 異常インスリンレセプタ- / 機能材料 / チロシンキナ-ゼ / Regulation of the gene expression / Human insulin receptor gene / site directed mutagenesis / インスリン作用機構 / プロモーター / 転写調節 / インスリンレセプター遺伝子 / Gq coupled receptor / signal transduction / soluble ectodomain / Gq共役受容体 / 可溶性細胞外ドメイン / ubiquitination / signal transductor / 血中遊離インスリン受容体 / ユビキチン化 / Serum insulin receptor / KO mouse / インスリン感受性亢進 / ノックアウトマウス / drug / proteome / protein phosphorylation / 経口糖尿病薬 / プロテオミクス / 抗糖尿病症 / リン酸化タンパク / AMP-activated protein kinase / Insulin signal translocation / 三量体GタンパクGq / AMPキナーゼ / グルコース利用 / Serumsubstance caused for insulin resistance / インスリン非依存型糖尿病 / GLUT4myc / トランスジェニックラット / インスリン抵抗性 / インスリン抵抗性原因物質 / Akt kinase / glucose transporter / drug for diabetes / 非アイソトープ測定 / Diabetes / glucosetransporter / G-proteins / GTP結合タンパク質 / 細胞増殖因子 / PI 3-キナーゼ / PI 3-kinase / PI-3キナーゼ / Mutation / 遺伝子診断 / Gene expression / Insulin receptor / Sp1 / 遺伝子発現 / 細胞増殖因子受容体 / キメラ受容体 / 可溶性インスリン受容体 / 生体分子医学 / 神経鞘種 / dbマウス / db / TGマウス / 脳 / レプチン / db/dbマウス / BIG2 / ARF / BFA / 超高感度sIR測定法 / 高血糖 / sIR / TUG / 分子病態学 / 転写因子 / 血中可溶性インスリン受容体 / トランスジェニックマウスマウス / Gqカップルレセプター / グルコース取り込み促進 / ゲノム的解析 / 肝臓 / AKt / ノルアドレナリン / 三量体Cタンパク / グルコストランスポータータイプ4 / 高次構造 / Gタンパク / エキソサイトーシス / GTP結合蛋白質 / PCR / インスリンレセプター異常 / インスリンセプター異常 / 異常インスリンレセプター / ヒトインスリンレセプター / 機能性材料 / インスリンレセプタ-異常 / タンパク質の局在化 / エンハンサ- / グルコ-ストランスポ-タ-タイプI / グルコ-ストランスポ-タ-遺伝子 / インスリンレセプタ-遺伝子 / 分化誘導因子 / 脂肪細胞 / 3T3-L1細胞 / トランスジェニック / 糖尿病モデルマウス / 受容体 … More Except Principal Investigator インスリン受容体 / APS / cDNAクローニング / 糖尿病 / internalization / インスリンレセプター / RFLP / diabetes / Akt / P72^<syk> / CSK / 遺伝子クローニング / 3-ケトアシルCoAチオラーゼ / オルニチントランスカルバミラーゼ / ユビキチン化 / ノックアウトマウス / プロテインキナ-ゼC / 分子情報伝達 / プロテインキナーゼC / シグナル伝達 / Diabetes Mellitus / Insulin Resistance / Deletion / Insulin Receptor Gene / Insulin Receptor / インスリン抵抗性糖尿病 / インスリンレセプター異常症 / インスリンレセプター遺伝子 / インスリン抵抗性 / インスリン受容体異常症 / 欠失 / インスリン受容体遺伝子 / Diabetes mellitus / Hereditary hyperammonemia / Urea cycle diseases / 尿素サイクル酵素群 / DNA診断 / インスリン受容体異常型糖尿病 / 先天性高アンモニア血症 / 先天性尿素サイクル病 / non-cleavable signal,cDNA sequence / presequence / mitochondrial protein import / 3-oxoacyl-CoA thiolase / Ornithine transcarbamylase / 蛋白質のミトコンドリア局在化 / ヒドロキシアシルCoAデヒドロゲナーゼ / ミトコンドリア蛋白質遺伝子 / 3ーケトアシルCoAチオラーゼ / オルニテントランスカルバミラーゼ / 内在性ミトコンドリア識別シグナル / cDNAの構造 / 遺伝子の構造 / 延長ペプチド / オルニチントランスカルバミナーゼ / glycemic marker / Soluble Insulin Receptor / 生理活性 / 血中可溶性インスリン受容体 / 血糖指標 / 可溶性インスリンレセプター / ubiquitination / insulin receptor / インスリン感受性亢進 / インスリンシグナル伝達 / インンスリン受容体 / structural analysis / crystallization / αsubunits / human insulin receptor / 抗糖尿病薬 / 結晶構造解析 / αサブユニット / SPORTS rats / orexin / microdialysis / serotonin / norepinephrine / monoamine oxidase / exercise / 自発運動 / マイクロダイアリシし / 最大酸素摂取量 / 脳内アミン / 運動 / ラット / SPORTSラット / オレキシン / マイクロダイアリシス / セロトニン / ノルエピナフリン / モノアミンオキシダーゼ / 運動習慣 / proteomics / insulin action / プロテオーム解析 / リン酸化タンパク質 / インスリン / プロテオミクス / インスリン作用 / insulin resistance / APS knockout mouse / carbobydrate metabolism / Gq / グルコース取り込み / GLUT4トランスロケーション / インスリン感受性 / APSノックマウス / 糖代謝 / Protein-tyrosine phosphatase / PI-3 kinase / Insulin-receptor kinase / cDNA cloning / EGF-receptor tyrosine kinase / P60^<src> / 細胞質チロシンキナ-ゼ / 蛋白質チロシンホスファタ-ゼ / EGF受容体 / PIキナ-ゼ / PDGF受容体 / p60^<cーyes> / p60^<cーsrc> / 蛋白質チロシンホスファタ-ゼI / EGF受容体チロシンキナ-ゼ / PI‐3キナ-ゼ / CDNAクロ-ニング / CDNAクローニング / 蛋白質チロシンホスファターゼ / p72^<syk> / EGF受容体チロシンキナーゼ / PI-3キナーゼ / p60^<src> / インターロイキン1産生能 / マクロファージ付着 / ヒトインスリン受容体 / ガス応答分子インターフェイス / タバコ葉 / 人工キメラ受容体 / 人工シナプス / 百日咳毒素(LAP) / Gタンパク質 / cAMPカスケード / PIレスポンス / 細胞増殖因子 / シグナル伝達機構 / プロセシングプロテアーゼ / ミトコンドリア識別と膜透過 / ミトコンドリア形成 / ユビチキン化 / c-kit受容体 / 細胞増殖抑制 / Sky / Gas6 / GLUT4のトランスロケーション / ソマトスタチン / ガストリン受容体 / HB-EGF / ErbB3 / インスリンシグナル伝達系 / スルホニール尿素受容体 / HEP受容体 / ErbBリガンド / c-Met受容体 / HGF / 細胞増殖制御 / Ras蛋白質 / がん細胞の浸潤性 / 肝細胞増殖因子 / 脱ユビキチン化酵素 / SH3ドメイン / Hrs結合蛋白質 / MAPキナーゼ / がん細胞の増殖制御 / c-Met / 肝細胞増殖因子(HGF) / 転写因子 / MAPキナ-ゼ / 情報伝達 / インスリンリセプタ- / 匂い情報変換 / エンケファリン / 2価リガンド / マクロファージ / ヒトインスリンレセプター / 分子インターフェイス / リセプター / 細胞増殖 Less

Is insulin inactivated by the binding with serum soluble insulin receptor(sIR)?Principal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
インスリン受容体過剰発現を用いた糖尿病の未来治療の試みPrincipal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of Insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
インスリン受容体細胞内ドメインは転写因子となりうるのか?Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes
- Principal Investigator
  
  OBATA Toshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
APSノックアウトマウスは肥満によるインスリン抵抗性を回避できる
- Principal Investigator
  
  小畑利之, 岸和弘
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
ヒト血清中に可溶性インスリンレセプターは存在するか?Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Mechanism of voluntary exercise and effect of exercise training on life-style related disease studied using a line of rats for high levels of voluntary wheel running
- Principal Investigator
  
  NAKAYA Y
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Sports science
- Research Institution
  The University of Tokushima
Crystallization and structural analysis of the human insulin receptor
- Principal Investigator
  
  OBATA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
Elucidation of the molecular mechanisms of insulin transduction using APS knockout mice
- Principal Investigator
  
  KISHI Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
PDGF投与により血糖値が下がるマウスを作れるか?Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Development of a drug for diabetes using human genome informationPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of glucose uptake by insulin-independent pathway
- Principal Investigator
  
  KISHI Kazuhiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
New cDNAs and proteins phosphorylated by insulin using proteome analysis
- Principal Investigator
  
  OBATA Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
インスリンは血中グルコース濃度を下げることのできる唯一のホルモンなのか?Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetas mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
肝細胞増殖因子受容体(c-Met)を介するシグナル伝達の分子機構
- Principal Investigator
  
  喜多村直実 (喜多村直美)
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Tokyo Institute of Technology
肝臓におけるインスリン作用不全がII型糖尿病発症の真の原因か?Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
インスリン受容体とその作用メカニズムの解析Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  The University of Tokushima
インスリンシグナル伝達転換マウスの作製Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Development of a simple screening system for the discovery of a new drug for diabetesPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
グルコーストランスポーターの構造・機能相関Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
myc-tagを用いたインスリン反応性グリコーストランスポーターの構造と機能解析Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Development of a simple screening system for the discovery of a new drug for diabetesPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
インスリン作用とGTP結合蛋白質Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリンシグナル伝達における蛋白質高次構造認識機構Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
グルコーストランスポーターの細胞内局在変化の分子メカニズムとインスリン作用Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリン作用とGTP結合蛋白質Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリンシグナル伝達における蛋白質高次構造認識機構Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
グルコーストランスポーターの細胞内局在変化の分子メカニズムとインスリン作用Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリンレセプター遺伝子異常と糖尿病Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリン作用とGTP結合蛋白質Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
生体受容体を機能性材料として開発するための基礎的研究Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリンレセプター遺伝子異常と糖尿病Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
生体受容体を機能材料として開発するための基礎的研究Principal Investigator
- Principal Investigator
  
  蝦名洋介
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製Principal Investigator
- Principal Investigator
  
  蝦名洋介
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリン刺激によるグルコ-ストランスポ-タ-の細胞内局在変化の分子メカニズムPrincipal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリンレセプタ-遺伝子異常と糖尿病Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and its disorderPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
細胞増殖シグナルの伝達・発現とその制御
- Principal Investigator
  
  鈴木紘一
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
細胞増殖シグナルによるグルコ-ストランスポ-タ-動的変化の分子機構Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
生体受容体を機能材料として開発するための基礎的研究Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
Protein-tyrosine phosphorylation and its biological significance
- Principal Investigator
  
  YAMAMURA Hirohei
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  General medical chemistry
- Research Institution
  Fukui Medical School
Establishment of a simple diagnostic method for the detection of mutations of insulin receptor gene in Non-Insulin Dependent Diabetes MellitusPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
細胞増殖シグナルの伝達とその制御
- Principal Investigator
  
  鈴木紘一
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Tokyo Metropolitan Organization for Medical Research
細胞増殖因子受容体チロシンキナーゼによる細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
生体情報伝達機能の発現と新機能材料の設計
- Principal Investigator
  
  相澤益男
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
ヒト異常インスリン受容体遺伝子導入による糖尿病モデルマウスの作製Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
インスリンシグナル伝達機構におけるGTP結合蛋白質の役割Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
3T3-L1線維芽細胞から脂肪細胞への分化誘導因子の分離と精製Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokushima
細胞増殖シグナルの発現・伝達とその制御
- Principal Investigator
  
  鈴木紘一
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
Structure and Function of Insulin Receptor, its Gene Expression and its Signal Transduction MechanismPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
細胞増殖制御系におけるシグナル伝達機構
- Principal Investigator
  
  上代淑人
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokyo
細胞増殖因子受容体チロシンキナーゼ細胞増殖の制御機構Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  The University of Tokushima
生体情報伝達機能の発現機構と新機能材料の設計
- Principal Investigator
  
  相澤益男
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
Analysis of Insulin Receptor Gene in Insulin Resistant Diabetes
- Principal Investigator
  
  MAKINO Hideichi
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内分泌・代謝学
- Research Institution
  Chiba University School of Medicine
新しい機能をもつ受容体作製の基礎的研究Principal Investigator
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
核支配ミトコンドリア蛋白質遺伝子の構造と発現
- Principal Investigator
  
  MORI Masataka
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kumamoto University
Structures, Expression and their Desorders of the Genes for Mitochondrial Proteins
- Principal Investigator
  
  MORI Masataka
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Kumamoto University
Structure and the regulation of the gene expression of the human insulin receptor gene and its abnormalitiesPrincipal Investigator
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Tokushima Univ.
  Kumamoto University
Development of DNA diagnosis of urea cycle diseases and diabetes due to insulin receptor abnormality
- Principal Investigator
  
  MORI Masataka
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kumamoto University Medical School

All 2010 2009 2008 2005

All Journal Article Presentation Patent

[Journal Article] A novel ultra-sensitive enzyme immunoassay for soluble human insulin receptor ectodomain and its measurement in urine from healthy subjects and patients with diabetes mellitus.2009
- Author(s)
  Umehara Asako, Nishioka Mamiko, Obata Toshiyuki, Ebina Yousuke, Shiota Hiroshi, Hashida Seiichi
- Journal Title
  
  Clinical biochemistry Vol.42, No.13-14
  
  Pages: 1468-1475
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390095
[Journal Article] The Rab GTPase-Activating Protein AS160 as A Common Regulator of Insulin- and Gq-Mediated Intracellular GLUT4 Vesicle DistributionA2009
- Author(s)
  Yuasa Tomoyuki, Uchiyama Keiji, Yuko OGURA, Kimura Masafumi, Kiyoshi TESHIGAWARA, Hosaka Toshio, Yoshinori TANAKA, Obata Toshiyuki, Hiroyuki SANO, Kishi Kazuhiro, Ebina Yousuke
- Journal Title
  
  Endocrine Journal Vol.56, No.3
  
  Pages: 345-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390095
[Patent] インスリンレセプターαサブユニットの測定方法2010
- Inventor(s)
  岡本英治、蛯名洋介、小畑利之
- Industrial Property Rights Holder
  (株)医学生物学研究所、蛯名洋介、小畑利之
- Acquisition Date
  2010-06-18
- Overseas
- Data Source
  KAKENHI-PROJECT-20390095
[Patent] 糖尿病の治療薬のスクリーニング方法2005
- Inventor(s)
  蛯名洋介, 小畑利之, 岡本英治
- Industrial Property Rights Holder
  蛯名洋介, 小畑利之, 岡本英治
- Industrial Property Number
  2005-172810
- Filing Date
  2005-06-13
- Data Source
  KAKENHI-PROJECT-17590269
[Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2010
- Author(s)
  Yuasa Tomoyuki, Nagaya Hisao, Hashida Seiichi, Asako Umehara, Yokota Ichiro, Obata Toshiyuki, Ebina Yousuke
- Organizer
  XI INTERNATIONAL SYMPOSIUM ON INSULIN RECEPTORS AND INSULIN ACTION
- Place of Presentation
  Naples
- Data Source
  KAKENHI-PROJECT-20390095
[Presentation] Soluble insulin receptor ectodomain in the plasma is a possible broad-spectrum tumor marker2009
- Author(s)
  湯浅智之, 矢野聖二, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
- Organizer
  第68回日本癌学会学術総会記事,pp.450-450
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-20390095
[Presentation] Role of BIG2, a Guanine-Nucleotide Exchanging Factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter Translocation2009
- Author(s)
  Uchiyama Keiji, Ebina Yousuke
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-20390095
[Presentation] 可溶化インスリン受容体細胞外ドメイン(sIR)は癌患者血清中で増加している2009
- Author(s)
  湯浅智之, 小畑利之, 矢野聖二, 岡本英治, 西岡安彦, 久保宜明, 高橋正幸, 中逵弘能, 長屋寿雄, 金山博臣, 荒瀬誠治, 曽根三郎, 蛯名洋介
- Organizer
  第29回日本分子腫瘍マーカー研究会
- Place of Presentation
  横浜
- Year and Date
  2009-09-30
- Data Source
  KAKENHI-PROJECT-20390095
[Presentation] 可溶性インスリン受容体細胞外ドメイン(sIRα)は高血糖に相関して血中濃度が高まる2009
- Author(s)
  湯浅智之, 小畑利之, 横田一郎, 岡本英治, 長屋寿雄, 橋田誠一, 前川聡, 柏木厚典, 松本満, 松本俊夫, 岸和弘, 蛯名洋介
- Organizer
  第7回1型糖尿病研究会
- Place of Presentation
  日光
- Year and Date
  2009-11-07
- Data Source
  KAKENHI-PROJECT-20390095
[Presentation] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes.2008
- Author(s)
  Yuasa Tomoyuki, Obata Toshiyuki, Yokota Ichiro, Okamoto Eiji, Kanezaki Yoshiko, Maegawa Hiroshi, Hirota Fumiko, Kishi Kazuhiro, Hashida Seiichi, Nagaya Hisao, Yuko Ogura, Kazuhiko Masuda, Matsumoto Mitsuru, Matsumoto Toshio, Kashiwagi Atsunori, Ebina Yousuke
- Organizer
  The 1st Insulin Resistance in Metabolic Disease Forum
- Place of Presentation
  Osaka
- Year and Date
  2008-08-20
- Data Source
  KAKENHI-PROJECT-20390095

1. HAYASHI Hideki (10218589)

# of Collaborated Projects: 26 results

# of Collaborated Products: 0 results
2. MURAKAMI Takashi (40210009)

# of Collaborated Projects: 24 results

# of Collaborated Products: 0 results
3. YUASA Tomoyuki (50304556)

# of Collaborated Projects: 23 results

# of Collaborated Products: 6 results
4. KISHI Kazuhiro (70284320)

# of Collaborated Projects: 21 results

# of Collaborated Products: 0 results
5. OBATA Toshiyuki (40325296)

# of Collaborated Projects: 16 results

# of Collaborated Products: 0 results
6. TAKIGUCHI Masaki (40179578)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
7. 鈴木紘一 (80011948)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
8. 山本正幸 (40114706)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
9. TESHIGAWARA Kiyoshi (40403737)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. MORI Masataka (40009650)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
11. 宇野功 (60114401)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
12. 野沢義則 (10021362)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
13. ASAHI Yoshihiko

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
14. HOSAKA Toshio (60403698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. YOKOYAMA Kazuhiro (00346602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
16. UCHIYAMA Keiji (60294039)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
17. NAGAYA Hisao (60464343)

# of Collaborated Projects: 2 results

# of Collaborated Products: 5 results
18. OGURA Yuko (90464354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
19. TANIGUCHI Hisaaki (10257636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
20. 野田亮 (30146708)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
21. 相澤益男 (00016742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
22. 筏義人 (00025909)

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# of Collaborated Products: 0 results
23. 松岡英明 (40016671)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
24. 伊庭英夫 (60111449)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
25. YAMAMURA Hirohei (90030882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. YAMAMOTO Masashi (40134621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. TAKEDA Masao (40030853)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KASUGA Masato (50161047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. NAKAGAWA Hachirou (20029937)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. NAKAYA Y (50136222)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. UETA Youichi (10232745)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KUSUNOKI Masami (90135749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. AMAYA Yoshihiro (50193032)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. MAKINO Hideichi (50009578)

# of Collaborated Projects: 1 results

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35. 木村俊作 (80150324)

# of Collaborated Projects: 1 results

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36. 喜多村直実 (80107424)

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37. 伝田公紀 (50212064)

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38. 清野進 (80236067)

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39. 松井利充 (10219371)

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40. 東山繁樹 (60202272)

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41. 大工原恭 (40028733)

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42. 上代淑人 (90012690)

# of Collaborated Projects: 1 results

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43. 西川克三 (10029960)

# of Collaborated Projects: 1 results

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44. MATSUOKA Yukio

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 岡本英治

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

EBINA Yousuke 蛯名 洋介

蝦名 洋介 エビナ ヨウスケ

Research Projects

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Co-Researchers

Is insulin inactivated by the binding with serum soluble insulin receptor(sIR)?Principal Investigator

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インスリン受容体過剰発現を用いた糖尿病の未来治療の試みPrincipal Investigator

Principal Investigator

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Molecular mechanisms of Insulin signal transduction and diabetes mellitusPrincipal Investigator

Principal Investigator

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Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator

Principal Investigator

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インスリン受容体細胞内ドメインは転写因子となりうるのか?Principal Investigator

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Principal Investigator

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Principal Investigator

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Review Section

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Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator

Principal Investigator

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ヒト血清中に可溶性インスリンレセプターは存在するか?Principal Investigator

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Principal Investigator

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Principal Investigator

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Molecular mechanisms of insulin signal transduction and diabetes mellitusPrincipal Investigator

Principal Investigator

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II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明Principal Investigator

Principal Investigator

EBINA Yousuke 蛯名洋介

蝦名洋介エビナヨウスケ