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OBATA Toshiyuki  小畑 利之

ORCIDConnect your ORCID iD *help
Researcher Number 40325296
Other IDs
Affiliation (Current) 2022: 滋賀医科大学, 医学部, 客員講師
Affiliation (based on the past Project Information) *help 2004 – 2006: The University of Tokushima, Institute for Enzyme Research, Associate Professor, 分子酵素学研究センター, 助教授
2005: 徳島大学, 分子酵素学研究センター, 教授
2000 – 2003: 徳島大学, 分子酵素学研究センター, 助手
Review Section/Research Field
Principal Investigator
Structural biochemistry / Structural biochemistry / Pathological medical chemistry
Except Principal Investigator
Biological Sciences / Pathological medical chemistry / General medical chemistry / General medical chemistry / Functional biochemistry
Keywords
Principal Investigator
糖尿病 / Akt / diabetes / インスリン受容体 / インスリン作用 / プロテオミクス / インスリン / リン酸化タンパク質 / プロテオーム解析 / insulin action … More / proteomics / αサブユニット / 結晶構造解析 / 抗糖尿病薬 / human insulin receptor / αsubunits / crystallization / structural analysis / 可溶性インスリンレセプター / 血糖指標 / シグナル伝達 / 血中可溶性インスリン受容体 / 生理活性 / Soluble Insulin Receptor / glycemic marker … More
Except Principal Investigator
APS / インスリン受容体 / 糖尿病 / internalization / インスリンシグナル伝達 / プロテオーム解析 / インスリン / ノックアウトマウス / ユビキチン化 / シグナル伝達 / GLUT4トランスロケーション / diabetes / insulin receptor / ポリモルフィズム / GLUT4 / 糖毒性 / インスリンレセプター / 血中マーカー / Gq / GLUT4 translocation / インスリン作用 / Insulin signalling / インスリン感受性亢進 / ubiquitination / AS160 / NIDDM / ゲノム的解析 / グルコース取り込み促進 / Gqカップルレセプター / II型糖尿病 / インスリン受容体遺伝子 / 血中可溶性インスリン受容体 / ユビチキン化 / 転写因子 / グルコース利用 / 三量体Gタンパク / AMPキナーゼ / 三量体GタンパクGq / Insulin signal translocation / Type 2 diabetes / glucose uptake / AMP-activated protein kinase / リン酸化タンパク / 抗糖尿病症 / 糖尿病薬 / Akt / プロテオミクス / 経口糖尿病薬 / protein phosphorylation / proteome / drug / グルコース取り込み / Aktキナーゼ / KO mouse / Serum insulin receptor / インンスリン受容体 / 血中遊離インスリン受容体 / signal transductor / 可溶性細胞外ドメイン / Gq共役受容体 / soluble ectodomain / signal transduction / Gq coupled receptor Less
  • Research Projects

    (15 results)
  • Research Products

    (8 results)
  • Co-Researchers

    (13 People)
  •  Molecular mechanisms of insulin signal transduction and diabetes mellitus

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  インスリン受容体細胞内ドメインは転写因子となりうるのか?

    • Principal Investigator
      蛯名 洋介
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetesPrincipal Investigator

    • Principal Investigator
      OBATA Toshiyuki
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  APSノックアウトマウスは肥満によるインスリン抵抗性を回避できるPrincipal Investigator

    • Principal Investigator
      小畑 利之, 岸 和弘
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of insulin signal transduction and diabetes mellitus

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  ヒト血清中に可溶性インスリンレセプターは存在するか?

    • Principal Investigator
      蛯名 洋介
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pathological medical chemistry
    • Research Institution
      The University of Tokushima
  •  Crystallization and structural analysis of the human insulin receptorPrincipal Investigator

    • Principal Investigator
      OBATA Toshiyuki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      The University of Tokushima
  •  Elucidation of the molecular mechanisms of insulin transduction using APS knockout mice

    • Principal Investigator
      KISHI Kazuhiro
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of insulin signal transduction and diabetes mellitus

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明

    • Principal Investigator
      蛯名 洋介
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Development of a drug for diabetes using human genome information

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima
  •  New cDNAs and proteins phosphorylated by insulin using proteome analysisPrincipal Investigator

    • Principal Investigator
      OBATA Toshiyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      The University of Tokushima
  •  II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  インスリンは血中グルコース濃度を下げることのできる唯一のホルモンなのか?

    • Principal Investigator
      蛯名 洋介
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Functional biochemistry
    • Research Institution
      The University of Tokushima
  •  Molecular mechanisms of insulin signal transduction and diabetas mellitus

    • Principal Investigator
      EBINA Yousuke
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      The University of Tokushima

All 2007 2005 2003

All Journal Article Patent

  • [Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus2007

    • Author(s)
      Obata, T., et. al.
    • Journal Title

      Diabetes 56

      Pages: 2028-2035

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18390104
  • [Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of payientswith diabetesmellitus.2007

    • Author(s)
      Toshiyuki Obata
    • Journal Title

      Diabetes 56

      Pages: 2028-2035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390104
  • [Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus.2007

    • Author(s)
      Obata T.
    • Journal Title

      Diabetes 56

      Pages: 2028-2035

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18390104
  • [Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003

    • Author(s)
      Toshiyuki Obata
    • Journal Title

      J.Biol.Chem. 278・30

      Pages: 28312-28323

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15570099
  • [Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003

    • Author(s)
      Toshiyuki Obata
    • Journal Title

      J.Biol.Chem. 278(30)

      Pages: 28312-28323

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590249
  • [Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003

    • Author(s)
      Toshiyuki Obata
    • Journal Title

      J.Biol.Chem. 278(30)

      Pages: 28312-28323

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15570099
  • [Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003

    • Author(s)
      Toshiyuki Obata
    • Journal Title

      J.Biol.Chem. 278・30

      Pages: 28312-28323

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590249
  • [Patent] 糖尿病の治療薬のスクリーニング方法2005

    • Inventor(s)
      蛯名 洋介, 小畑 利之, 岡本 英治
    • Industrial Property Rights Holder
      蛯名 洋介, 小畑 利之, 岡本 英治
    • Industrial Property Number
      2005-172810
    • Filing Date
      2005-06-13
    • Data Source
      KAKENHI-PROJECT-17590269
  • 1.  EBINA Yousuke (00112227)
    # of Collaborated Projects: 15 results
    # of Collaborated Products: 0 results
  • 2.  YUASA Tomoyuki (50304556)
    # of Collaborated Projects: 14 results
    # of Collaborated Products: 0 results
  • 3.  KISHI Kazuhiro (70284320)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 0 results
  • 4.  TESHIGAWARA Kiyoshi (40403737)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  HOSAKA Toshio (60403698)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  YOKOYAMA Kazuhiro (00346602)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 7.  TANIGUCHI Hisaaki (10257636)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  KUSUNOKI Masami (90135749)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  UCHIYAMA Keiji (60294039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAGAYA Hisao (60464343)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  OGURA Yuko (90464354)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  ASAHI Yoshihiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  岡本 英治
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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