OBATA Toshiyuki 小畑利之

Researcher Number	40325296
Other IDs
Affiliation (Current)	2023: 滋賀医科大学, 医学部, 客員講師
Affiliation (based on the past Project Information) *help	2004 – 2006: The University of Tokushima, Institute for Enzyme Research, Associate Professor, 分子酵素学研究センター, 助教授 2005: 徳島大学, 分子酵素学研究センター, 教授 2000 – 2003: 徳島大学, 分子酵素学研究センター, 助手
Review Section/Research Field	Principal Investigator Structural biochemistry / Structural biochemistry / Pathological medical chemistry Except Principal Investigator Biological Sciences / Pathological medical chemistry / General medical chemistry / General medical chemistry / Functional biochemistry
Keywords	Principal Investigator 糖尿病 / Akt / diabetes / インスリン受容体 / インスリン作用 / プロテオミクス / インスリン / リン酸化タンパク質 / プロテオーム解析 / insulin action … More / proteomics / αサブユニット / 結晶構造解析 / 抗糖尿病薬 / human insulin receptor / αsubunits / crystallization / structural analysis / 可溶性インスリンレセプター / 血糖指標 / シグナル伝達 / 血中可溶性インスリン受容体 / 生理活性 / Soluble Insulin Receptor / glycemic marker … More Except Principal Investigator APS / インスリン受容体 / 糖尿病 / internalization / インスリンシグナル伝達 / プロテオーム解析 / インスリン / ノックアウトマウス / ユビキチン化 / シグナル伝達 / GLUT4トランスロケーション / diabetes / insulin receptor / ポリモルフィズム / GLUT4 / 糖毒性 / インスリンレセプター / 血中マーカー / Gq / GLUT4 translocation / インスリン作用 / Insulin signalling / インスリン感受性亢進 / ubiquitination / AS160 / NIDDM / ゲノム的解析 / グルコース取り込み促進 / Gqカップルレセプター / II型糖尿病 / インスリン受容体遺伝子 / 血中可溶性インスリン受容体 / ユビチキン化 / 転写因子 / グルコース利用 / 三量体Gタンパク / AMPキナーゼ / 三量体GタンパクGq / Insulin signal translocation / Type 2 diabetes / glucose uptake / AMP-activated protein kinase / リン酸化タンパク / 抗糖尿病症 / 糖尿病薬 / Akt / プロテオミクス / 経口糖尿病薬 / protein phosphorylation / proteome / drug / グルコース取り込み / Aktキナーゼ / KO mouse / Serum insulin receptor / インンスリン受容体 / 血中遊離インスリン受容体 / signal transductor / 可溶性細胞外ドメイン / Gq共役受容体 / soluble ectodomain / signal transduction / Gq coupled receptor Less

Molecular mechanisms of insulin signal transduction and diabetes mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
インスリン受容体細胞内ドメインは転写因子となりうるのか?
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetesPrincipal Investigator
- Principal Investigator
  
  OBATA Toshiyuki
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
APSノックアウトマウスは肥満によるインスリン抵抗性を回避できるPrincipal Investigator
- Principal Investigator
  
  小畑利之, 岸和弘
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
ヒト血清中に可溶性インスリンレセプターは存在するか?
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
Crystallization and structural analysis of the human insulin receptorPrincipal Investigator
- Principal Investigator
  
  OBATA Toshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
Elucidation of the molecular mechanisms of insulin transduction using APS knockout mice
- Principal Investigator
  
  KISHI Kazuhiro
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetes mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Development of a drug for diabetes using human genome information
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima
New cDNAs and proteins phosphorylated by insulin using proteome analysisPrincipal Investigator
- Principal Investigator
  
  OBATA Toshiyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokushima
II型糖尿病の遺伝要因のゲノム的解析と分子病態の解明
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
インスリンは血中グルコース濃度を下げることのできる唯一のホルモンなのか?
- Principal Investigator
  
  蛯名洋介
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of insulin signal transduction and diabetas mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  The University of Tokushima

All 2007 2005 2003

All Journal Article Patent

[Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus2007
- Author(s)
  Obata, T., et. al.
- Journal Title
  
  Diabetes 56
  
  Pages: 2028-2035
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390104
[Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of payientswith diabetesmellitus.2007
- Author(s)
  Toshiyuki Obata
- Journal Title
  
  Diabetes 56
  
  Pages: 2028-2035
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390104
[Journal Article] Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetes mellitus.2007
- Author(s)
  Obata T.
- Journal Title
  
  Diabetes 56
  
  Pages: 2028-2035
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18390104
[Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003
- Author(s)
  Toshiyuki Obata
- Journal Title
  
  J.Biol.Chem. 278・30
  
  Pages: 28312-28323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570099
[Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003
- Author(s)
  Toshiyuki Obata
- Journal Title
  
  J.Biol.Chem. 278(30)
  
  Pages: 28312-28323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590249
[Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003
- Author(s)
  Toshiyuki Obata
- Journal Title
  
  J.Biol.Chem. 278(30)
  
  Pages: 28312-28323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570099
[Journal Article] Use of RNA-interference-mediated gene silencing and adenoviral overexpression to Elucidate the roles of AKT/PKB-isoforms in insulin actions2003
- Author(s)
  Toshiyuki Obata
- Journal Title
  
  J.Biol.Chem. 278・30
  
  Pages: 28312-28323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590249
[Patent] 糖尿病の治療薬のスクリーニング方法2005
- Inventor(s)
  蛯名洋介, 小畑利之, 岡本英治
- Industrial Property Rights Holder
  蛯名洋介, 小畑利之, 岡本英治
- Industrial Property Number
  2005-172810
- Filing Date
  2005-06-13
- Data Source
  KAKENHI-PROJECT-17590269

1. EBINA Yousuke (00112227)

# of Collaborated Projects: 15 results

# of Collaborated Products: 0 results
2. YUASA Tomoyuki (50304556)

# of Collaborated Projects: 14 results

# of Collaborated Products: 0 results
3. KISHI Kazuhiro (70284320)

# of Collaborated Projects: 11 results

# of Collaborated Products: 0 results
4. TESHIGAWARA Kiyoshi (40403737)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. HOSAKA Toshio (60403698)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YOKOYAMA Kazuhiro (00346602)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TANIGUCHI Hisaaki (10257636)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KUSUNOKI Masami (90135749)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. UCHIYAMA Keiji (60294039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAGAYA Hisao (60464343)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. OGURA Yuko (90464354)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. ASAHI Yoshihiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 岡本英治

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OBATA Toshiyuki 小畑 利之

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Soluble insulin receptor ectodomain is elevated in the plasma of patients with diabetesPrincipal Investigator

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APSノックアウトマウスは肥満によるインスリン抵抗性を回避できるPrincipal Investigator

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Crystallization and structural analysis of the human insulin receptorPrincipal Investigator

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New cDNAs and proteins phosphorylated by insulin using proteome analysisPrincipal Investigator

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OBATA Toshiyuki 小畑利之