Uchiyama Keiji 内山圭司

… Alternative Names

UCHIYAMA Keiji 内山圭司

UOHIYAMA Keiji 内山圭司

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Researcher Number	60294039
Other IDs
External Links
Affiliation (Current)	2025: 国立研究開発法人医薬基盤・健康・栄養研究所, 医薬基盤研究所創薬デザイン研究センター, プロジェクト研究員
Affiliation (based on the past Project Information) *help	2023 – 2024: 徳島大学, 先端酵素学研究所, 特任准教授 2016 – 2019: 徳島大学, 先端酵素学研究所(次世代), 准教授 2014 – 2015: 徳島大学, 疾患酵素学研究センター, 准教授 2007 – 2011: The University of Tokushima, Institute for Enzyme Research, Associate Professor 2006: 三菱化学生命科学研究所, 研究部門, 研究員 … More 2005 – 2006: 株式会社三菱化学生命科学研究所, 研究部門, 研究員 2005: 株式会社三菱化学生命科学研究所, 研究員 1998 – 1999: 大阪大学, 大学院・工学研究科, 助手 1997: Osaka University, Faculty of Engineering, Assistant Professor, 工学部, 助手 Less
Review Section/Research Field	Principal Investigator Virology / Cell biology / Basic Section 50010:Tumor biology-related / Biological Sciences / Functional biochemistry Except Principal Investigator 生物・生体工学 / Pathological medical chemistry / Biological Sciences / Basic Section 55010:General surgery and pediatric surgery-related
Keywords	Principal Investigator 異常プリオン / プリオン病 / プリオン / 抗プリオン活性 / ソーティリン / 膜融合 / p97 / ゴルジ体 / O型糖鎖修飾 / 小胞体ストレス … More / がん微小環境 / Liver X receptor / T0901317 / エタノールアミン / 細胞内小胞輸送 / 抗プリン活性 / 神経変性疾患 / ソーティリン欠損細胞 / ンソーティリン欠損マウス / プリオン高感受性 / タパク質分解 / プリオン分解 / タンパク質分解 / レトロマー複合体 / プリオン感染 / VPS35 / レトロマー / ソーティング / Sortilin / 3T3-L1脂肪 / リサイクリングエンドソーム / Glut4小胞再構成 / インスリン / 脂肪細胞 / インスリン作用 / Glut4トランスロケーション / BIG2 / Glut4 / p37 / SNARE / 細胞内膜融合 / 細胞構造・機能 / p47 / VCP135 / VCP / 97 / ユビキチン / VCIP135 … More Except Principal Investigator AS160 / bacteriocin / 乳酸菌 / バクテリオシン / GLUT4トランスロケーション / シグナル伝達 / p47 / p37 / p97ATPase / 膜融合 / ゴルジ体 / 小胞体 / ステープル化ペプチド / がん抑制因子 / ペプチド創薬 / トラスツズマブ耐性 / HER2陽性乳がん / Gq coupled receptor / GLUT4 translocation / signal transduction / diabetes / soluble ectodomain / insulin receptor / インスリン / Gq共役受容体 / 糖尿病 / 可溶性細胞外ドメイン / インスリン受容体 / maltose / dissolved oxygen concentration / cascade controller / nisin / mixed culture / yeasts / lactic acid bacteria / ラクトース / マルトース / 溶存酸素濃度 / カスケード制御 / ナイシン / 混合培養 / 酵母 / immunity for enterocin A / E. faecium / shuttle vector / enterocin A / Enterococcus faecium / Lactobacillus plantarum / 発酵食品 / バクテリオシン耐性遺伝子 / E.faecium / シャトルベクター / エンテロシンA / wavelet filter / fault diagnosis / autoassociative neural network / temperature controllable gene expression / ウェーブレット変換 / 状態認識 / ウェーブレットフィルタ / 自己想起型ニューラルネットワーク / 異常診断 / 温度感受性組換え酵母 / BIG2 / ARF / BFA / 超高感度sIR測定法 / 高血糖 / sIR / TUG / GLUT4 / インスリン作用 / インスリンシグナル伝達 / 分子病態学 / VCIP135 / 網状構造 Less

がん微小環境でのIRE1恒常的活性化に必須な小胞体-ゴルジ体間シャトル輸送機構の解明Principal Investigator
- Principal Investigator
  
  内山圭司
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  The University of Tokushima
A therapeutic strategy to overcome drug resistance in HER2-positive breast cancer targeting the BIG3-PHB2 complexes
- Principal Investigator
  
  吉丸哲郎
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
Membrane trafficking involved in the degradation of aged brain proteinPrincipal Investigator
- Principal Investigator
  
  内山圭司
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Elucidation of the mechanism of Sortilin reduction by prion infection and its application to therapeutic method developmentPrincipal Investigator
- Principal Investigator
  
  UCHIYAMA Keiji
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  The University of Tokushima
Development of basic technology for therapy of prion diseases based on Sortilin functionPrincipal Investigator
- Principal Investigator
  
  UCHIYAMA Keiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  The University of Tokushima
Role of BIG2, a Guanine-Nucleotide Exchanging factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter TranslocationPrincipal Investigator
- Principal Investigator
  
  UCHIYAMA Keiji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  The University of Tokushima
Molecular mechanisms of Insulin signal transduction and diabetes mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
ldentification and function analysis of a SNARE complex for p97/p37-mediated membrane fusion pathwayPrincipal Investigator
- Principal Investigator
  
  UOHIYAMA Keiji
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  The University of Tokushima
新規の細胞内膜融合機構p97/p37経路の解明
- Principal Investigator
  
  近藤久雄
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
Molecular mechanisms of insulin signal transduction and diabetes mellitus
- Principal Investigator
  
  EBINA Yousuke
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  The University of Tokushima
小胞体の網状構造の形成機構
- Principal Investigator
  
  近藤久雄
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
  Mitsubishi Kagaku Institute of Life Sciences
p97を介したゴルジ体再構成過程におけるVCIP135による脱ユビキチン化の役割Principal Investigator
- Principal Investigator
  
  内山圭司
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Cell biology
- Research Institution
  Mitsubishi Kagaku Institute of Life Sciences
Isolation of a novel bacteriocin-producing lactic acid bacteria and its use in food preservation
- Principal Investigator
  
  SHIOYA Suteaki
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  生物・生体工学
- Research Institution
  Osaka University
Development of a novel controller for antimicrobial nisin production, using interaction of microorganisms
- Principal Investigator
  
  SHIMIZU Hiroshi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  生物・生体工学
- Research Institution
  Osaka University
Development of an on-line fault diagnosis and operation system for an optimal rice-alphaamylase production process of temperature-sensitive mutant of Saccharomyces cerevisiae by autoassociative neural network
- Principal Investigator
  
  SHIOYA Suteaki
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  生物・生体工学
- Research Institution
  Osaka University

All 2017 2016 2015 2014 2012 2011 2009 2007 2006 2005 Other

All Journal Article Presentation

[Journal Article] Prions amplify through degradation of the VPS10P sorting receptor sortilin.2017
- Author(s)
  Uchiyama K, Tomita M, Yano M, Chida J, Hara H, Das NR, Nykjaer A, Sakaguchi S
- Journal Title
  
  PLoS Pathogenes
  
  Volume: - Issue: 6 Pages: e1006470-e1006470
- DOI
  10.1371/journal.ppat.1006470
- NAID
  120006334183
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K08859, KAKENHI-PUBLICLY-17H05702
[Journal Article] Prion Protein Devoid of the Octapeptide Repeat Region Delays BSE Pathogenesis in Mice.2017
- Author(s)
  2.Hara H, Miyata H, Das N, Chida J, Yoshimochi T, Uchiyama K, Watanabe H, Kondoh G, Yokoyama T and Sakaguchi S.
- Journal Title
  
  Journal of Virology
  
  Volume: 92
- NAID
  120006458155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08859
[Journal Article] Novel Amplification Mechanism of Prions through Disrupting Sortilin-Mediated Trafficking.2017
- Author(s)
  Suehiro Sakaguchi, Keiji Uchiyama
- Journal Title
  
  Prion
  
  Volume: 11 Issue: 6 Pages: 398-404
- DOI
  10.1080/19336896.2017.1391435
- NAID
  120006537522
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-17K08859, KAKENHI-PUBLICLY-17H05702
[Journal Article] Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice2017
- Author(s)
  Das Nandita Rani、Miyata Hironori、Hara Hideyuki、Uchiyama Keiji、Chida Junji、Yano Masashi、Watanabe Hitomi、Kondoh Gen、Sakaguchi Suehiro
- Journal Title
  
  Archives of Virology
  
  Volume: 162 Pages: 1867-1876
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05702
[Journal Article] Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.2017
- Author(s)
  Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
- Journal Title
  
  Archives of Virology
  
  Volume: 印刷中 Issue: 7 Pages: 1867-1876
- DOI
  10.1007/s00705-017-3295-3
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K08859
[Journal Article] Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice.2017
- Author(s)
  Hara H, Miyata H, Das NR, Chida J, Yoshimochi T, Uchiyama K, Watanabe H, Kondoh G, Yokoyama T, Sakaguchi S
- Journal Title
  
  Journal of Virology
  
  Volume: - Issue: 1
- DOI
  10.1128/jvi.01368-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10029, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-15K21098, KAKENHI-PUBLICLY-17H05702
[Journal Article] Development of in vitro model of insulin receptor cleavage induced by high glucose in HepG2 cells.2014
- Author(s)
  Yuasa T, Amo K, Ishikura S, Nagaya H, Uchiyama K, Hashida S and Ebina Y.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 445 Pages: 236-243
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460557
[Journal Article] Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice.2014
- Author(s)
  Uchiyama K, Miyata H, Yano M, Yamaguchi Y, Imamura M, Muramatsu N, Das NR, Chida J, Hara H, Sakaguchi S.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 10 Pages: e109737-e109737
- DOI
  10.1371/journal.pone.0109737
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870474, KAKENHI-PROJECT-25870479, KAKENHI-PROJECT-26460557
[Journal Article] VCIP135 deubiquitinase and its binding protein, WAC, in p97ATPase-mediated membrane fusion2011
- Author(s)
  Totsukawa G, Kaneko Y, Uchiyama K, Toh H, Tamura K, and Kondo H
- Journal Title
  
  The EMBO Journal
  
  Volume: Vol.30, No.17 Pages: 3455-3474
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570142
[Journal Article] The Rab GTPase-Activating Protein AS160 as A Common Regulator of Insulin-and G. q-Mediated Intracellular GLUT4 Vesicle Distribution2009
- Author(s)
  Yuasa, T, Uchiyama K., Ogura, Y., Kimura M., Teshigawara K., Hosaka T., Tanaka, Y., Obata T., Sano H., Kishi K., and Ebina Y.
- Journal Title
  
  Endocrine J.
  
  Volume: Vol.56, No.3 Pages: 345-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21570142
[Journal Article] The Rab GTPase-Activating Protein AS160 as A Common Regulator of Insulin- and Gq-Mediated Intracellular GLUT4 Vesicle DistributionA2009
- Author(s)
  Yuasa Tomoyuki, Uchiyama Keiji, Yuko OGURA, Kimura Masafumi, Kiyoshi TESHIGAWARA, Hosaka Toshio, Yoshinori TANAKA, Obata Toshiyuki, Hiroyuki SANO, Kishi Kazuhiro, Ebina Yousuke
- Journal Title
  
  Endocrine Journal Vol.56, No.3
  
  Pages: 345-359
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390095
[Journal Article] 細胞内小器官維持のための新たな分子機構2007
- Author(s)
  近藤久雄、内山圭司、十津川剛
- Journal Title
  
  実験医学 25巻
  
  Pages: 848-851
- Data Source
  KAKENHI-PROJECT-19570195
[Journal Article] p37is a p97 adaptor required for Golgi and ER biogenesis in interphase and at the end of mitosis2006
- Author(s)
  Uchiyama, K., Totskawa G., Puhka, M., Kaneko, Y., Jokitalo J., Dreveny I., Beuron F., Zhang X., Freemont P., Kondo H.
- Journal Title
  
  Developmental Cell 11・6
  
  Pages: 803-816
- Data Source
  KAKENHI-PROJECT-17770180
[Journal Article] p37 is a p97 adaptor required for Golgl and ER biogenesis in Interphase and at the end of mitosis.2006
- Author(s)
  Uchiyama K, et al.
- Journal Title
  
  Developmental Cell 11
  
  Pages: 803-816
- Data Source
  KAKENHI-PROJECT-17028060
[Journal Article] p37 is a p97 adaptor required for Golgi and ER biogenesis in Interphase and at the end of mitosis.2006
- Author(s)
  Uchiyama K, et al.
- Journal Title
  
  Developmental Cell 11
  
  Pages: 803-816
- Data Source
  KAKENHI-PROJECT-18050046
[Journal Article] p97/p47-mediated biogenesis of Golgi and ER2005
- Author(s)
  Keiji Uchiyama, Hisao Kondo
- Journal Title
  
  J Biochem 137
  
  Pages: 115-119
- NAID
  10017342840
- Data Source
  KAKENHI-PROJECT-17028060
[Journal Article] p97/p47-Mediated biogenesis of Golgi and ER.2005
- Author(s)
  Uchiyama K., Kondo H.
- Journal Title
  
  J Biochem (Tokyo) 137・2
  
  Pages: 115-119
- NAID
  10017342840
- Data Source
  KAKENHI-PROJECT-17770180
[Journal Article] NSF/SNAPs and p97/p47/VCIP135 are sequentially required for cell cycle-dependent reformation of the ER network.2005
- Author(s)
  Kano F, Kondo H, Yamamoto A, Kaneko Y, Uchiyama K, Hosokawa N, Nagata K, Murata M.
- Journal Title
  
  Genes Cells 10・10
  
  Pages: 989-999
- Data Source
  KAKENHI-PROJECT-17770180
[Presentation] High susceptibility of Sortilin-deficient cells to prion infection.2017
- Author(s)
  Uchiyama K, Toko T, Sakaguchi S.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PUBLICLY-17H05702
[Presentation] High susceptibility of Sortilin-deficient cells to prion infection.2017
- Author(s)
  Uchiyama K, Toko T, Sakaguchi S.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08859
[Presentation] Intracellular secretion analysis of recombinant therapeutic antibodies in engineered CHO cells aiming to establish high produce.2017
- Author(s)
  Kaneyoshi K, Uchiyama K, Onitsuka M, Yamano N, Koga Y and Omasa T
- Organizer
  The 25th Meeting of the European Society for Animal Cell Technology (ESACT2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08859
[Presentation] Prion propagation through sortilin degradation.2017
- Author(s)
  Sakaguchi S and Uchiyama K
- Organizer
  第60回日本神経化学会大会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08859
[Presentation] Identification and investigation of a novel anti-prion compound.2017
- Author(s)
  Uchiyama, K and Sakaguchi S.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PUBLICLY-17H05702
[Presentation] Intracellular secretion analysis of recombinant therapeutic antibodies in engineered CHO cells aiming to establish high produce.2017
- Author(s)
  Kaneyoshi K, Uchiyama K, Onitsuka M, Yamano N, Koga Y and Omasa T
- Organizer
  The 25th Meeting of the European Society for Animal Cell Technology (ESACT2017)
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05702
[Presentation] Identification and investigation of a novel anti-prion compound.2017
- Author(s)
  Uchiyama, K and Sakaguchi S.
- Organizer
  第65回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08859
[Presentation] Prion propagation through sortilin degradation.2017
- Author(s)
  Sakaguchi S and Uchiyama K
- Organizer
  第60回日本神経化学会大会シンポジウム
- Invited
- Data Source
  KAKENHI-PUBLICLY-17H05702
[Presentation] Dysfunction of Sortilin by prion infection2016
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Sorting of prion protein and PrPSc accumulation2016
- Author(s)
  Uchiyama K and Sakaguchi S
- Organizer
  International Prion Congress-Prion 2016
- Place of Presentation
  一橋講堂（東京都・千代田区）
- Year and Date
  2016-05-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン病－異常プリオン蓄積メカニズムの解明2016
- Author(s)
  内山圭司
- Organizer
  シンポジウム「蛋白質の構造と病態」
- Place of Presentation
  グランドパレス徳島（徳島県徳島市）
- Year and Date
  2016-02-13
- Invited
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Analysis of intracellular recombinant IgG secretion in engineered CHO cells2016
- Author(s)
  Kaneyoshi K, Uchiyama K, Onitsuka M, Yamano N, Koga Y and Omasa T
- Organizer
  The 29th Annual and International Meeting of the Japanese Association for Animal Cell Technology (JAACT2016 Kobe)
- Place of Presentation
  神戸国際会議場（兵庫県・神戸市）
- Year and Date
  2016-11-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Sorting of prion protein and PrPSc accumulation2016
- Author(s)
  Keiji Uchiyama
- Organizer
  International Prion congress - Prion 2016
- Place of Presentation
  Hitotsubashi Hall, Tokyo, Japan
- Year and Date
  2016-05-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン病における異常プリオンの蓄積メカニズム2016
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Analysis of roles of N-terminal region of prion protein in the conversion into scrapie form by using prion-knockout cell.2015
- Author(s)
  Tomita M, Uchiyama K, Usui T and Sakaguchi S
- Organizer
  Asia Pacific Prion symposium
- Place of Presentation
  Ishikawa Ongakudo, Kanazawa, Japan
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Mechanism of Sortilin-mediated PrP degradation.2015
- Author(s)
  Uchiyama K, Tomita M and Sakaguchi S
- Organizer
  Asia Pacific Prion symposium
- Place of Presentation
  Ishikawa Ongakudo, Kanazawa, Japan
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015
- Author(s)
  Uchiyama K, Tomita M and Sakaguchi S
- Organizer
  第63回日本ウイルス学会学術集会ワークショップ「Prions」
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015
- Author(s)
  内山圭司，富田満，坂口末廣
- Organizer
  Biochemistry and Molecular Biology (BMB) 2015 (第38回日本分子生物学会年会、第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Novel molecular mechanism for accumulation of abnormal prion protein - Inhibition of Sortilin-mediated PrP degradation.2015
- Author(s)
  Uchiyama K and Sakaguchi S
- Organizer
  第15回蛋白質科学会年会ワークショップ「New development of prion biology」
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Functional roles of TUG and p97/ VCP in Glut4 trafficking2012
- Author(s)
  Uchiyama, K. and Ebina, Y.
- Organizer
  第34回分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2012-12-16
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] Functional roles of TUG and p97/VCP in Glut4 trafficking2011
- Author(s)
  Keiji Uchiyama
- Organizer
  第34回分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)(ポスター発表)
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] プリオン感染細胞における細胞内小胞輸送の抑制2011
- Author(s)
  内山圭司, 坂口末廣
- Organizer
  第26回中国四国ウイルス研究会
- Place of Presentation
  徳島大学(徳島市)
- Year and Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] プリオン感染細胞における細胞内小胞輸送の抑制2011
- Author(s)
  内山圭司
- Organizer
  第26回中国四国ウイルス研究会
- Place of Presentation
  徳島大学(徳島県)
- Year and Date
  2011-06-20
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] Functional roles of TUG and p97/VCP in Glut4 trafficking2011
- Author(s)
  Keiji Uchiyama
- Organizer
  第34回分子生物学会年会
- Place of Presentation
  パシフィコ横浜(神奈川県)(口頭発表)
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] Role of BIG2, a guanine-nucleotide exchanging factor for ADP-Ribosylation favtors, in insulin-regulated glucose transporter translocation2009
- Author(s)
  Uchiyama, K. and Ebina, Y.
- Organizer
  第32回分子生物学会年会
- Place of Presentation
  パシフィコ横浜(横浜市)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] Role of BIG2, a guanine-nucleotide exchanging factor for ADP-Ribosylation favtors, in insulin-regulated glucose transporter translocation.2009
- Author(s)
  内山圭司
- Organizer
  分子生物学会年会
- Place of Presentation
  横浜(パシフィコ横浜)
- Year and Date
  2009-12-09
- Data Source
  KAKENHI-PROJECT-21570142
[Presentation] Role of BIG2, a Guanine-Nucleotide Exchanging Factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter Translocation2009
- Author(s)
  Uchiyama Keiji, Ebina Yousuke
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-20390095
[Presentation] プリオン感染と小胞輸送障害
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第87回日本生化学会大会シンポジウム「認知症克服に向けて：プリオン病をもっと知る」
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Prions disturb post-Golgi membrane trafficking to the cell surface.
- Author(s)
  Uchiyama K. and Sakaguchi S.
- Organizer
  The 9th International Symposium of the Institute Network
- Place of Presentation
  大阪大学（大阪府吹田市）
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染によるポストゴルジ小胞輸送障害
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第29回中国四国ウイルス研究会
- Place of Presentation
  山口大学（山口県山口市）
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオンによるポストゴルジ膜輸送障害
- Author(s)
  坂口末廣，内山圭司
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-11-20 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] 新規プリオン結合因子Sortilinのプリオン感染における役割
- Author(s)
  内山圭司，富田満，臼井健，坂口末廣
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオンノックアウト細胞を用いたプリオンタンパク質Ｎ末端領域の異常プリオン形成における役割の解明
- Author(s)
  富田満，臼井健，内山圭司，坂口末廣
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Post-Golgi trafficking of membrane proteins impaired by prion infection.
- Author(s)
  Uchiyama K. and Sakaguchi S.
- Organizer
  International Prion Congress-Prion 2014
- Place of Presentation
  Trieste, Italy
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26460557

1. SHIOYA Suteaki (50026259)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
2. SHIMIZU Hiroshi (00226250)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. EBINA Yousuke (00112227)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. YUASA Tomoyuki (50304556)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
5. NAGAYA Hisao (60464343)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. OGURA Yuko (90464354)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 近藤久雄 (20205561)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
8. 十津川剛 (90399684)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. SAKAGUCHI Suehiro (60274635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
10. YANO Masashi (10531858)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. 中嶋幹男 (00273590)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 小畑利之 (40325296)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 勅使河原匡 (40403737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 吉丸哲郎 (80424729)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. CHIDA Junji

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
16. HARA Hideuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results

Uchiyama Keiji 内山 圭司

UCHIYAMA Keiji 内山 圭司

UOHIYAMA Keiji 内山 圭司

Research Projects

Research Products

Co-Researchers

がん微小環境でのIRE1恒常的活性化に必須な小胞体-ゴルジ体間シャトル輸送機構の解明Principal Investigator

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Membrane trafficking involved in the degradation of aged brain proteinPrincipal Investigator

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Elucidation of the mechanism of Sortilin reduction by prion infection and its application to therapeutic method developmentPrincipal Investigator

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Development of basic technology for therapy of prion diseases based on Sortilin functionPrincipal Investigator

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Role of BIG2, a Guanine-Nucleotide Exchanging factor for ADP-Ribosylation Factors, in Insulin-Regulated Glucose Transporter TranslocationPrincipal Investigator

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ldentification and function analysis of a SNARE complex for p97/p37-mediated membrane fusion pathwayPrincipal Investigator

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p97を介したゴルジ体再構成過程におけるVCIP135による脱ユビキチン化の役割Principal Investigator

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Uchiyama Keiji 内山圭司

UCHIYAMA Keiji 内山圭司

UOHIYAMA Keiji 内山圭司