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Sakaguchi Suehiro  坂口 末廣

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SAKAGUCHI Suehiro  坂口 末廣

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Researcher Number 60274635
Affiliation (Current) 2020: 徳島大学, 先端酵素学研究所, 教授
Affiliation (based on the past Project Information) *help 2020: 徳島大学, 先端酵素学研究所, 教授
2016 – 2019: 徳島大学, 先端酵素学研究所(次世代), 教授
2016: 徳島大学, 先端酵素学研究所, 教授
2013 – 2015: 徳島大学, 疾患酵素学研究センター, 教授
2008 – 2010: 徳島大学, 疾患酵素学研究センター, 教授 … More
2004 – 2005: Nagasaki University, Graduate School of Biomedical Sciences, Associate Professor, 大学院・医歯薬学総合研究科, 助教授
2002 – 2004: 長崎大学, 大学院・医歯薬学総合研究科, 講師
2000 – 2001: Nagasaki University, Graduate School of Medical Sciences, Assistant Professor, 大学院・医学研究科, 講師
2000: 長崎大学, 医学研究科, 講師
1999: NAGASAKI UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF BACTERIOLOGY, ASSISTANT PROFESSOR, 医学部, 講師
1997 – 1998: 長崎大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Virology / Neurology / Virology / Infectious disease medicine / General internal medicine and related fields / Basic Section 51030:Pathophysiologic neuroscience-related
Except Principal Investigator
Neurochemistry/Neuropharmacology / Clinical veterinary science / Neuroscience in general … More / Neurology / Virology / Biological pharmacy / Virology Less
Keywords
Principal Investigator
プリオン / 神経変性 / プリオン蛋白 / プリオン病 / ノックアウトマウス / プルキンエ細胞 / プリオン蛋白類似蛋白 / ソーチリン / プリオン蛋白質 / 遺伝子欠損マウス … More / 遺伝子導入マウス / 受容体 / プリオンタンパク質 / prion / インフルエンザウイルス / クロイツフェルト・ヤコブ病 / プリオン蛋白(PrP) / プリオン蛋白類似蛋白(PrPLP) / トランスジェニックマウス / 構造変換 / 蛋白質輸送 / 蛋白質分解 / 小胞輸送 / ポストゴルジ輸送 / 結合分子 / prion protein / インフルエンザ / 活性酸素種 / 銅イオン / 抗体 / プリオン蛋白欠損マウス / 伝播性海綿状脳症 / 神経細胞変性 / ファージディスプレイ法 / ペプチド療法 / intergenic splicing / pre-mRNA / 3'プロセッシング / siRNA / 神経芽細胞腫 / 感受性 / 狂牛病 / 神経変性疾患 / アトラクチン / インスリン受容体 / ポストゴルジ小胞輸送 / 細胞膜蛋白質 / Tgマウス / リポソーム / knockout mouse / liposome / アルカリフォスファターゼ / 結合蛋白 / リコンビナント蛋白 / two-hybrid法 / タグ / クローニング / binding protein / receptor / alkali phosphatase / シグナル / yeast-two hybrid / 細胞死 / 凝集体 / 蛋白分解 / yeast-two hyb / yeast two-hybrid / binding molecule / prion disease / cell death / aggregate / 銅/亜鉛依存性スーパーオキシドジスムターゼ / アポトーシス / 酸化ストレス / リード化合物 / 細胞内小胞輸送 / スーパーオキサイドジスムターゼ / Src / Srcファミリーキナーゼ / マクロファージ / A型インフルエンザウイルス / 銅 / スーパーオキシドジスムターゼ / 異常プリオン蛋白質 / 病原体 / インターロイキン1β … More
Except Principal Investigator
プリオン病 / プリオン蛋白 / 神経細胞死 / ペプチド / プリオン / ファージディスプレイ / トランスジェニックマウス / 神経変性 / プルキンエ細胞 / 軸索 / 遺伝子改変動物 / アストロサイト / 脱髄 / PRION PROTEIN / ノックアウトマウス / S100A13 / FGF-1 / Ca^<2+> / STI / NDI / 獣医学 / 蛋白質 / 脳神経疾患 / ターゲティングマウス / TARGETED MYTAGENESIS / PURKINJE CELLS / NEURODEGENERATION / DEMYELINATION / 蛋白蛋白相互作用 / 発症遅延 / 発症予防 / ペプチドライブラリ / 遺伝子改変マウス / ニューロン / グリア / PRION DISEASES / PEPTIDES / THERAPEUTICS / PROTEIN-PROTEIN INTERACTION / RNAスプライシング / 遺伝子ノックアウトマウス / 生理機能 / ファージデイスプレイ / Prion diseases / Prion protein / Neurodegeneration / RNA splicing / Gene-knockout mice / ストレス / non-classical release / 無血清 / ネクローシス / 分泌 / 核移行 / 低酸素 / S100 / Stress / non-vesicular release / serum starvation / 異常プリオン / Sortilin / ソーティング / レトロマー / VPS35 / ソーティリン / プリオン感染 / レトロマー複合体 / タンパク質分解 / プリオン分解 / タパク質分解 / プリオン高感受性 / ンソーティリン欠損マウス / ソーティリン欠損細胞 Less
  • Research Projects

    (24 results)
  • Research Products

    (65 results)
  • Co-Researchers

    (25 People)
  •  Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion diseasePrincipal InvestigatorOngoing

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 51030:Pathophysiologic neuroscience-related
    • Research Institution
      The University of Tokushima
  •  Prion protein is a target molecule for a novel anti-influenza therapeuticPrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Suehiro
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Research Field
      General internal medicine and related fields
    • Research Institution
      The University of Tokushima
  •  プリオン以外のプリオン病の病原体の同定とその病原性メカニズムの解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2017 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Elucidation of our recent findings on the protective role of prion protein against lethal infection with influenza A viruses is useful for development of a new type of anti-influenza drugsPrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Suehiro
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Infectious disease medicine
    • Research Institution
      The University of Tokushima
  •  プリオンの増殖と病原性獲得に重要なプリオンの細胞内移動に関与する分子の同定Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokushima
  •  Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion diseasePrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Suehiro
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      The University of Tokushima
  •  Development of basic technology for therapy of prion diseases based on Sortilin function

    • Principal Investigator
      UCHIYAMA Keiji
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      The University of Tokushima
  •  Identification of a host molecule inportant for prion infectionPrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Suehiro
    • Project Period (FY)
      2013 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      The University of Tokushima
  •  The development of a ultra-sensitive diagnostic technique for BSE(Mad cow disease)

    • Principal Investigator
      YAMAGUCHI Yoshitaka
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Clinical veterinary science
    • Research Institution
      The University of Tokushima
  •  Elucidation of a signaling pathway of prion protein in neuronal cellsPrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Suehiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Nagasaki University
  •  プリオン病における神経細胞変性死の分子機構解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Functional proteomics analysis of non-vesicular release mechanisms in stress exposed neuron-role of stress-induced non-vesicular release Prion, NDI and FGF-1 in neuron

    • Principal Investigator
      UEDA Hiroshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biological pharmacy
    • Research Institution
      Nagasaki University
  •  プリオン病における神経細胞変性死の分子機構解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  PrP pre-mRNA 3'プロセッシング異常と神経細胞死の分子機構解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Identification of prion-receptor moleculesPrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Ssuehiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Virology
    • Research Institution
      Nagasaki University
  •  プリオン病における神経細胞変性死の分子機構解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  プリオン蛋白欠損マウスで認められる加齢に伴う神経細胞変性死の分子機構解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  プリオン病における神経細胞変性死の分子機構解明Principal Investigator

    • Principal Investigator
      坂口 末廣
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      Nagasaki University
  •  Molecular Mechanisms for Purkinje Cell Degeneration and Demyelination in Prion Protein-Deficient Mice.

    • Principal Investigator
      KATAMINE Shigeru
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Virology
    • Research Institution
      Nagasaki University
  •  プリオン蛋白(PrP)結合ペプチドの同定とそのプリオン病治療への応用

    • Principal Investigator
      片峰 茂
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Nagasaki University
  •  MECHANISMS OF NEUTONAL CELL DEATH IN PRION PROTEIN-LESS MICE

    • Principal Investigator
      KATAMINE Shigeru
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Neuroscience in general
    • Research Institution
      Nagasaki University
  •  Elucidation of the nature of a Creutfeldt-Jakob disease agent using prion protein gene-knockout micePrincipal Investigator

    • Principal Investigator
      SAKAGUCHI Suehiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Virology
    • Research Institution
      NAGASAKI UNIVERSITY
  •  MOLECULAR MECHANISMS FOR PRION PROTEIN CONVERSION AND CELL-TYPES INVOLVED IN THE CONVERSION IN VIVO

    • Principal Investigator
      KATAMINE Shigeru
    • Project Period (FY)
      1997 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      NAGASAKI UNIVERSITY
  •  クロイツフェルト・ヤコブ病の病原因子はプリオンでない可能性があるPrincipal Investigator

    • Principal Investigator
      坂口 末廣, 宮本 勉
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Virology
    • Research Institution
      Nagasaki University

All 2020 2019 2018 2017 2016 2015 2014 2010 2009 2008 Other

All Journal Article Presentation

  • [Journal Article] Prion Protein is a Novel Modulator of Influenza: Potential Implications for Anti-Influenza Therapeutics2020

    • Author(s)
      Sakaguchi Suehiro、Chida Junji
    • Journal Title

      Current Issues in Molecular Biology

      Volume: 37 Pages: 21-32

    • DOI

      10.21775/cimb.037.021

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19H03548
  • [Journal Article] The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region.2020

    • Author(s)
      Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
    • Journal Title

      Molecular Neurobiology

      Volume: 57 Pages: 1203-1216

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03548
  • [Journal Article] Cellular prion protein-mediated protection against influenza A virus infection2019

    • Author(s)
      Chida Junji、Sakaguchi Suehiro
    • Journal Title

      Future Virology

      Volume: 14 Pages: 31-37

    • DOI

      10.2217/fvl-2018-0146

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-17K19661
  • [Journal Article] Roles of Prion Protein in Virus Infections.2018

    • Author(s)
      Sakaguchi Suehiro、Chida Junji
    • Journal Title

      DNA Cell Biol.

      Volume: 37 Pages: 808-811

    • DOI

      10.1089/dna.2018.4402

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K19661
  • [Journal Article] Prion protein protects mice from lethal infection with influenza A viruses.2018

    • Author(s)
      Chida Junji、Hara Hideyuki、Yano Masashi、Uchiyama Keiji、Das Nandita Rani、Takahashi Etsuhisa、Miyata Hironori、Tomioka Yukiko、Ito Toshihiro、Kido Hiroshi、Sakaguchi Suehiro
    • Journal Title

      PLoS Pathog.

      Volume: 14

    • DOI

      10.1371/journal.ppat.1007049

    • NAID

      120006524496

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07499, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K19661
  • [Journal Article] Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein2018

    • Author(s)
      Linsenmeier Luise、Mohammadi Behnam、Wetzel Sebastian、Puig Berta、Jackson Walker S.、Hartmann Alexander、Uchiyama Keiji、Sakaguchi Suehiro、Endres Kristina、Tatzelt Joerg、Saftig Paul、Glatzel Markus、Altmeppen Hermann C.
    • Journal Title

      Molecular Neurodegeneration

      Volume: 13 Pages: 18-18

    • DOI

      10.1186/s13024-018-0248-6

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-17K19661
  • [Journal Article] 宿主因子を標的にした新たなインフルエンザ治療の試み2018

    • Author(s)
      千田淳司、木戸博、坂口末廣
    • Journal Title

      BIO Clinica

      Volume: 33 Pages: 52-55

    • Data Source
      KAKENHI-PROJECT-17K19661
  • [Journal Article] Novel Amplification Mechanism of Prions through Disrupting Sortilin-Mediated Trafficking.2017

    • Author(s)
      Suehiro Sakaguchi, Keiji Uchiyama
    • Journal Title

      Prion

      Volume: 11 Pages: 398-404

    • DOI

      10.1080/19336896.2017.1391435

    • NAID

      120006537522

    • Data Source
      KAKENHI-PUBLICLY-17H05701
  • [Journal Article] Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice2017

    • Author(s)
      Hara H, Miyata H, Das NR, Chida J, Yoshimochi T, Uchiyama K, Watanabe H, Kondoh G, Yokoyama T, Sakaguchi S
    • Journal Title

      Journal of Virology

      Volume: -

    • DOI

      10.1128/jvi.01368-17

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K10029, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-15K21098
  • [Journal Article] Melanin or a Melanin-Like Substance Interacts with the N-Terminal Portion of Prion Protein and Inhibits Abnormal Prion Protein Formation in Prion-Infected Cells.2017

    • Author(s)
      Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Ayumi Oguma, Kenta Teruya, Hiroshi Kurahashi, Hideyuki Hara, Suehiro Sakaguchi, Katsumi Doh-ura
    • Journal Title

      J Virol.

      Volume: 印刷中

    • DOI

      10.1128/jvi.01862-16

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-16H05317, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K01804
  • [Journal Article] Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.2017

    • Author(s)
      Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
    • Journal Title

      Arc. Virol.

      Volume: 印刷中 Pages: 1867-1876

    • DOI

      10.1007/s00705-017-3295-3

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K10029
  • [Journal Article] Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal rResidues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice.2014

    • Author(s)
      Uchiyama K, Miyata H, Yano M, Yamaguchi Y, Imamura M, Muramatsu N, Das NR, Chida J, Hara H, Sakaguchi S.
    • Journal Title

      PLOS ONE

      Volume: 9

    • DOI

      10.1371/journal.pone.0109737

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25870474, KAKENHI-PROJECT-25870479, KAKENHI-PROJECT-26460557
  • [Journal Article] Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions.2010

    • Author(s)
      Koji Fujita, Yoshitaka Yamaguchi, suyoshi Mori, Naomi Muramatsu, Takahito Miyamoto, Masashi Yano, Hironori Miyata, Akira Ootsuyama, Makoto Sawada, Haruo Matsuda, Ryuji Kaji , Suehiro Sakaguchi.
    • Journal Title

      Cellular and Molecular Neurobiology in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Journal Article] Cellular prion protein prevents brain damage after encephalomyocarditis virus infection in mice.2008

    • Author(s)
      Nasu-Nishimura Y, Taniuchi Y, Nishimura T, Sakudo A, Nakajima K, Ano Y, Sugiura K, Sakaguchi S, Itohara S, Onodera T.
    • Journal Title

      Arch Virol. 153(6)

      Pages: 1007-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Journal Article] Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like rotein/doppel in mice.2008

    • Author(s)
      Yoshikawa D, Yamaguchi N, Ishibashi D, Yamanaka H, Okimura N, Yamaguchi Y, Mori T, Miyata H, Shigematsu K, Katamine S, Sakaguchi S.
    • Journal Title

      J Biol Chem. 283(35)

      Pages: 24202-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Presentation] プリオン蛋白質はインフルエンザAウイルス感染による重症化を軽減する2019

    • Author(s)
      千田 淳司、原 英之、坂口 末廣
    • Organizer
      第 42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03548
  • [Presentation] ウイルス感染を用いたプリオン病発症機構の解明2019

    • Author(s)
      原 英之、千田 淳司、坂口 末廣
    • Organizer
      第 42回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-19H03548
  • [Presentation] インフルエンザウイルス感染は神経細胞において異常型プリオン産生のトリガーとなる2018

    • Author(s)
      原 英之、千田 淳司、坂口 末廣
    • Organizer
      第 40回日本分子生物学会年会
    • Data Source
      KAKENHI-PUBLICLY-17H05701
  • [Presentation] インフルエンザウイルス感染は神経細胞において異常型プリオン産生のトリガーとなる2018

    • Author(s)
      原 英之、千田 淳司、坂口 末廣
    • Organizer
      第 40回日本分子生物学会年会
    • Data Source
      KAKENHI-PROJECT-17K19661
  • [Presentation] プリオン蛋白質はインフルエンザAウイルス感染に防御的に機能する2018

    • Author(s)
      千田 淳司、原 英之、坂口 末廣
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PUBLICLY-17H05701
  • [Presentation] プリオン蛋白質はインフルエンザAウイルス感染に防御的に機能する2018

    • Author(s)
      千田 淳司、原 英之、坂口 末廣
    • Organizer
      第66回日本ウイルス学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K19661
  • [Presentation] 肺で発現する正常プリオン蛋白質の機能解析2017

    • Author(s)
      千田淳司、原英之、坂口 末廣
    • Organizer
      第32回中国四国ウイルス研究会
    • Data Source
      KAKENHI-PROJECT-17K19661
  • [Presentation] プリオン蛋白質はインフルエンザAウイルスの感染を制御する2017

    • Author(s)
      千田淳司、原英之、坂口 末廣
    • Organizer
      2017年度生命科学系学会合同年次大会 (ConBio2017)
    • Data Source
      KAKENHI-PROJECT-17K19661
  • [Presentation] Sorting of prion protein and PrPSc accumulation.2016

    • Author(s)
      Keiji Uchiyama, Suehiro Sakaguchi
    • Organizer
      PRION 2016/Asian Pacific Prion Symposium 2016
    • Place of Presentation
      Hitotsubashi Hall, National Center of Science Building, Tokyo(東京都千代田区)
    • Year and Date
      2016-05-10
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] Sorting of prion protein and PrPSc accumulation.2016

    • Author(s)
      Keiji Uchiyama, Suehiro Sakaguchi
    • Organizer
      PRION 2016/Asian Pacific Prion Symposium 2016
    • Place of Presentation
      Hitotsubashi Hall, National Center of Science Building, Tokyo(東京都千代田区)
    • Year and Date
      2016-05-10
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01560
  • [Presentation] Dysfunction of Sortilin by prion infection2016

    • Author(s)
      内山圭司,坂口末廣
    • Organizer
      第64回日本ウイルス学会学術集会
    • Place of Presentation
      札幌コンベンションセンター(北海道・札幌市)
    • Year and Date
      2016-10-23
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン病における異常プリオンの蓄積メカニズム2016

    • Author(s)
      内山圭司、坂口末廣
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] 蛋白質凝集体「プリオン」による抗インフルエンザウイルス活性機構の解明2016

    • Author(s)
      原英之、千田淳司、坂口末廣
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-15K15380
  • [Presentation] プリオン病における異常プリオンの蓄積メカニズム2016

    • Author(s)
      内山圭司,坂口末廣
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] Sorting of prion protein and PrPSc accumulation2016

    • Author(s)
      Uchiyama K and Sakaguchi S
    • Organizer
      International Prion Congress-Prion 2016
    • Place of Presentation
      一橋講堂(東京都・千代田区)
    • Year and Date
      2016-05-10
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン病における異常プリオンの蓄積メカニズム2016

    • Author(s)
      内山圭司、坂口末廣
    • Organizer
      第39回日本分子生物学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-11-30
    • Data Source
      KAKENHI-PUBLICLY-15H01560
  • [Presentation] Novel molecular mechanism for accumulation of abnormal prion protein;Inhibition of Sortilin-mediated PrP degradation2015

    • Author(s)
      内山圭司、坂口末廣
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] プリオン病におけるポストゴルジ小胞輸送障害2015

    • Author(s)
      坂口末廣
    • Organizer
      革新的医療研究開発で挑む神経変性疾患―プリオン病治験耐性の確立に向けてー
    • Place of Presentation
      名古屋国際会議場国際会議室(愛知県名古屋市)
    • Year and Date
      2015-02-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] Mechanism of sortilin-mediated PrP degradation.2015

    • Author(s)
      Keiji Uchiyama, Mitsuru Tomita, Suehiro Sakaguchi
    • Organizer
      Asian Pacific Prion Symposium 2015
    • Place of Presentation
      Ishikawa Ongakudo, Kanazawa, Japan
    • Year and Date
      2015-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-15H01560
  • [Presentation] Mechanism of sortilin-mediated PrP degradation.2015

    • Author(s)
      Keiji Uchiyama, Mitsuru Tomita, Suehiro Sakaguchi
    • Organizer
      Asian Pacific Prion Symposium 2015
    • Place of Presentation
      Ishikawa Ongakudo, Kanazawa, Ishikawa
    • Year and Date
      2015-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] Novel molecular mechanism for accumulation of abnormal prion protein;Inhibition of Sortilin-mediated PrP degradation2015

    • Author(s)
      内山圭司、坂口末廣
    • Organizer
      第15回日本蛋白質科学会年会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-15H01560
  • [Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015

    • Author(s)
      内山 圭司, 富田満、坂口 末廣
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] 次世代抗インフルエンザ薬の宿主ターゲット分子の発見とその治療効果2015

    • Author(s)
      坂口末廣
    • Organizer
      四国地区五大学 新技術説明会
    • Place of Presentation
      JST東京本部別館1Fホール(東京・市ヶ谷)
    • Year and Date
      2015-11-27
    • Data Source
      KAKENHI-PROJECT-15K15380
  • [Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015

    • Author(s)
      内山 圭司, 富田満、坂口 末廣
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      Fukuoka International Congress Center(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015

    • Author(s)
      内山 圭司, 富田満、坂口 末廣
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      Fukuoka International Congress Center(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PUBLICLY-15H01560
  • [Presentation] プリオン病におけるポストゴルジ小胞輸送障害2015

    • Author(s)
      坂口末廣
    • Organizer
      革新的医療研究開発で挑む神経変性疾患―プリオン病治験耐性の確立に向けてー
    • Place of Presentation
      名古屋国際会議場国際会議室(愛知県・名古屋市)
    • Year and Date
      2015-02-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670422
  • [Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015

    • Author(s)
      内山圭司,富田満,坂口末廣
    • Organizer
      Biochemistry and Molecular Biology (BMB) 2015 (第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] 蛋白質感染粒子「プリオン」と細胞内小胞輸送2015

    • Author(s)
      坂口末廣
    • Organizer
      第8回共同利用・共同研究「酵素学研究拠点」シンポジウム―タンパク質代謝・分解系の酵素学―
    • Place of Presentation
      徳島大学藤井節郎記念ホール(徳島県徳島市)
    • Year and Date
      2015-02-10
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] Analysis of roles of N-terminal region of prion protein in the conversion into scrapie form by using prion-knockout cell.2015

    • Author(s)
      Tomita M, Uchiyama K, Usui T and Sakaguchi S
    • Organizer
      Asia Pacific Prion symposium
    • Place of Presentation
      Ishikawa Ongakudo, Kanazawa, Japan
    • Year and Date
      2015-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015

    • Author(s)
      内山 圭司、富田満、坂口 末廣
    • Organizer
      第38回日本分子生物学会年会 第88回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PUBLICLY-15H01560
  • [Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015

    • Author(s)
      Uchiyama K, Tomita M and Sakaguchi S
    • Organizer
      第63回日本ウイルス学会学術集会 ワークショップ「Prions」
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2015-11-22
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] Novel molecular mechanism for accumulation of abnormal prion protein - Inhibition of Sortilin-mediated PrP degradation.2015

    • Author(s)
      Uchiyama K and Sakaguchi S
    • Organizer
      第15回蛋白質科学会年会ワークショップ「New development of prion biology」
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2015-06-24
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] Mechanism of Sortilin-mediated PrP degradation.2015

    • Author(s)
      Uchiyama K, Tomita M and Sakaguchi S
    • Organizer
      Asia Pacific Prion symposium
    • Place of Presentation
      Ishikawa Ongakudo, Kanazawa, Japan
    • Year and Date
      2015-09-04
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] 異なるプリオン株に異なる感受性を示すプリオン蛋白:プリオン株産生メカニズムについての考察2010

    • Author(s)
      坂口末廣、宮田博規、山口仁孝、村松直美、森剛志
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Presentation] プリオン蛋白構造変換におけるアミノ酸91-104領域の役割2010

    • Author(s)
      山口仁孝、村松直美、森剛志、坂口末廣
    • Organizer
      第58回日本ウイルス学会学術集会
    • Place of Presentation
      徳島
    • Year and Date
      2010-11-07
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Presentation] プリオン蛋白オクタペプチドリピート領域はプリオンの病原性を決定する2009

    • Author(s)
      宮田博規、山口仁孝、坂口末廣
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Presentation] プリオン構造変換に関与するN末端領域の機能解析2009

    • Author(s)
      山口仁孝、村松直美、藤田浩司、坂口末廣
    • Organizer
      第57回日本ウイルス学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-25
    • Data Source
      KAKENHI-PROJECT-20580354
  • [Presentation] Post-Golgi trafficking of membrane proteins impaired by prion infection.

    • Author(s)
      Uchiyama K. and Sakaguchi S.
    • Organizer
      International Prion Congress-Prion 2014
    • Place of Presentation
      Trieste, Italy
    • Year and Date
      2014-05-27 – 2014-05-30
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン感染によるポストゴルジ小胞輸送障害

    • Author(s)
      内山圭司,坂口末廣
    • Organizer
      第66回日本細胞生物学会大会
    • Place of Presentation
      奈良県新公会堂(奈良県奈良市)
    • Year and Date
      2014-06-11 – 2014-06-13
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオンによるポストゴルジ膜輸送障害

    • Author(s)
      坂口末廣、内山圭司
    • Organizer
      第36回生体膜と薬物の相互作用シンポジウム「生体膜における蛋白質の機能制御システムと疾患」
    • Place of Presentation
      徳島大学蔵本キャンパス 大塚講堂、藤井節郎記念ホール(徳島県徳島市)
    • Year and Date
      2014-11-20 – 2014-11-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] 新規プリオン結合因子Sortilinのプリオン感染における役割

    • Author(s)
      内山圭司,富田満,臼井健,坂口末廣
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン感染と小胞輸送障害

    • Author(s)
      内山 圭司, 坂口 末廣
    • Organizer
      第87回日本生化学会, シンポジウム 認知症克服に向けて:プリオン病をもっと知る
    • Place of Presentation
      国立京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-26293212
  • [Presentation] Prions disturb post-Golgi membrane trafficking to the cell surface.

    • Author(s)
      Uchiyama K. and Sakaguchi S.
    • Organizer
      The 9th International Symposium of the Institute Network
    • Place of Presentation
      大阪大学(大阪府吹田市)
    • Year and Date
      2014-06-19 – 2014-06-20
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン感染と小胞輸送障害

    • Author(s)
      内山圭司,坂口末廣
    • Organizer
      第87回日本生化学会大会シンポジウム「認知症克服に向けて:プリオン病をもっと知る」
    • Place of Presentation
      京都国際会館(京都府京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] 新規プリオン結合因子Sortilinのプリオン感染における役割

    • Author(s)
      内山 圭司, 富田満、臼井健、坂口 末廣
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜会議センター(神奈川県・横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-25670422
  • [Presentation] プリオンノックアウト細胞を用いたプリオンタンパク質N末端領域の異常プリオン形成における役割の解明

    • Author(s)
      富田満,臼井健,内山圭司,坂口末廣
    • Organizer
      第62回日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす

    • Author(s)
      内山圭司、坂口 末廣
    • Organizer
      第29回中国四国ウイルス研究会
    • Place of Presentation
      山口大学吉田キャンパス(山口県・吉田)
    • Year and Date
      2014-06-28 – 2014-06-29
    • Data Source
      KAKENHI-PROJECT-25670422
  • [Presentation] プリオン感染と小胞輸送障害

    • Author(s)
      内山 圭司, 坂口 末廣
    • Organizer
      第87回日本生化学会, シンポジウム 認知症克服に向けて:プリオン病をもっと知る
    • Place of Presentation
      国立京都国際会館(京都府・京都市)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-25670422
  • [Presentation] プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす

    • Author(s)
      内山圭司,坂口末廣
    • Organizer
      第29回中国四国ウイルス研究会
    • Place of Presentation
      山口大学(山口県山口市)
    • Year and Date
      2014-06-28 – 2014-06-29
    • Data Source
      KAKENHI-PROJECT-26460557
  • [Presentation] プリオンによるポストゴルジ膜輸送障害

    • Author(s)
      坂口末廣,内山圭司
    • Organizer
      第36回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      徳島大学(徳島県徳島市)
    • Year and Date
      2014-11-20 – 2014-11-21
    • Invited
    • Data Source
      KAKENHI-PROJECT-26460557
  • 1.  KATAMINE Shigeru (40161062)
    # of Collaborated Projects: 5 results
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  • 2.  SHIGEMATSU Kazutio (20154205)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 3.  HARA Hideyuki (40469953)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 14 results
  • 4.  YANO Masashi (10531858)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 5.  NIWA Msaki (20136641)
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  • 6.  SHIRABE Susumu (40264220)
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  • 7.  千田 淳司 (20437651)
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    # of Collaborated Products: 8 results
  • 8.  YAMAGUCHI Yoshitaka (90432765)
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    # of Collaborated Products: 6 results
  • 9.  KATAOKA Yasufumi (70136513)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  UEDA Hiroshi (00145674)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  INOUE Makoto (60380987)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  FUJITA Ryousuke (70380855)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  UCHIYAMA Keiji (60294039)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 17 results
  • 14.  宮本 勉 (10004582)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  水野 恭伸 (40311865)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  吉田 明 (70257187)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  DERI Maria.A
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  TERUYA Kenta
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 19.  NISHIZAWA Keiko
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 20.  OGUMA Ayumi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 21.  SAKASEGAWA Yuji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 22.  高橋 悦久
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 23.  木戸 博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 24.  渡邊 仁美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 25.  堂浦 克美
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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