Sakaguchi Suehiro 坂口末廣

… Alternative Names

Researcher Number	60274635
Affiliation (Current)	2020: 徳島大学, 先端酵素学研究所, 教授
Affiliation (based on the past Project Information) *help	2020: 徳島大学, 先端酵素学研究所, 教授 2016 – 2019: 徳島大学, 先端酵素学研究所(次世代), 教授 2016: 徳島大学, 先端酵素学研究所, 教授 2013 – 2015: 徳島大学, 疾患酵素学研究センター, 教授 2008 – 2010: 徳島大学, 疾患酵素学研究センター, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Virology / Neurology / Virology / Infectious disease medicine / General internal medicine and related fields / Basic Section 51030:Pathophysiologic neuroscience-related Except Principal Investigator Neurochemistry/Neuropharmacology / Clinical veterinary science / Neuroscience in general … More
Keywords	Principal Investigator プリオン / 神経変性 / プリオン蛋白 / プリオン病 / ノックアウトマウス / プルキンエ細胞 / プリオン蛋白類似蛋白 / ソーチリン / プリオン蛋白質 / 遺伝子欠損マウス … More Except Principal Investigator プリオン病 / プリオン蛋白 / 神経細胞死 / ペプチド / プリオン / ファージディスプレイ / トランスジェニックマウス / 神経変性 / プルキンエ細胞 / 軸索 / 遺伝子改変動物 / アストロサイト / 脱髄 / PRION PROTEIN / ノックアウトマウス / S100A13 / FGF-1 / Ca^<2+> / STI / NDI / 獣医学 / 蛋白質 / 脳神経疾患 / ターゲティングマウス / TARGETED MYTAGENESIS / PURKINJE CELLS / NEURODEGENERATION / DEMYELINATION / 蛋白蛋白相互作用 / 発症遅延 / 発症予防 / ペプチドライブラリ / 遺伝子改変マウス / ニューロン / グリア / PRION DISEASES / PEPTIDES / THERAPEUTICS / PROTEIN-PROTEIN INTERACTION / RNAスプライシング / 遺伝子ノックアウトマウス / 生理機能 / ファージデイスプレイ / Prion diseases / Prion protein / Neurodegeneration / RNA splicing / Gene-knockout mice / ストレス / non-classical release / 無血清 / ネクローシス / 分泌 / 核移行 / 低酸素 / S100 / Stress / non-vesicular release / serum starvation / 異常プリオン / Sortilin / ソーティング / レトロマー / VPS35 / ソーティリン / プリオン感染 / レトロマー複合体 / タンパク質分解 / プリオン分解 / タパク質分解 / プリオン高感受性 / ンソーティリン欠損マウス / ソーティリン欠損細胞 Less

Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion diseasePrincipal InvestigatorOngoing
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 51030:Pathophysiologic neuroscience-related
- Research Institution
  The University of Tokushima
Prion protein is a target molecule for a novel anti-influenza therapeuticPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  General internal medicine and related fields
- Research Institution
  The University of Tokushima
プリオン以外のプリオン病の病原体の同定とその病原性メカニズムの解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Elucidation of our recent findings on the protective role of prion protein against lethal infection with influenza A viruses is useful for development of a new type of anti-influenza drugsPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  The University of Tokushima
プリオンの増殖と病原性獲得に重要なプリオンの細胞内移動に関与する分子の同定Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokushima
Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion diseasePrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
Development of basic technology for therapy of prion diseases based on Sortilin function
- Principal Investigator
  
  UCHIYAMA Keiji
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  The University of Tokushima
Identification of a host molecule inportant for prion infectionPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  The University of Tokushima
The development of a ultra-sensitive diagnostic technique for BSE(Mad cow disease)
- Principal Investigator
  
  YAMAGUCHI Yoshitaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Clinical veterinary science
- Research Institution
  The University of Tokushima
Elucidation of a signaling pathway of prion protein in neuronal cellsPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
プリオン病における神経細胞変性死の分子機構解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Functional proteomics analysis of non-vesicular release mechanisms in stress exposed neuron-role of stress-induced non-vesicular release Prion, NDI and FGF-1 in neuron
- Principal Investigator
  
  UEDA Hiroshi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Nagasaki University
プリオン病における神経細胞変性死の分子機構解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
PrP pre-mRNA 3'プロセッシング異常と神経細胞死の分子機構解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Identification of prion-receptor moleculesPrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Ssuehiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
プリオン病における神経細胞変性死の分子機構解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
プリオン蛋白欠損マウスで認められる加齢に伴う神経細胞変性死の分子機構解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
プリオン病における神経細胞変性死の分子機構解明Principal Investigator
- Principal Investigator
  
  坂口末廣
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Nagasaki University
Molecular Mechanisms for Purkinje Cell Degeneration and Demyelination in Prion Protein-Deficient Mice.
- Principal Investigator
  
  KATAMINE Shigeru
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
プリオン蛋白(PrP)結合ペプチドの同定とそのプリオン病治療への応用
- Principal Investigator
  
  片峰茂
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Nagasaki University
MECHANISMS OF NEUTONAL CELL DEATH IN PRION PROTEIN-LESS MICE
- Principal Investigator
  
  KATAMINE Shigeru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Neuroscience in general
- Research Institution
  Nagasaki University
Elucidation of the nature of a Creutfeldt-Jakob disease agent using prion protein gene-knockout micePrincipal Investigator
- Principal Investigator
  
  SAKAGUCHI Suehiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  NAGASAKI UNIVERSITY
MOLECULAR MECHANISMS FOR PRION PROTEIN CONVERSION AND CELL-TYPES INVOLVED IN THE CONVERSION IN VIVO
- Principal Investigator
  
  KATAMINE Shigeru
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  NAGASAKI UNIVERSITY
クロイツフェルト・ヤコブ病の病原因子はプリオンでない可能性があるPrincipal Investigator
- Principal Investigator
  
  坂口末廣, 宮本勉
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Virology
- Research Institution
  Nagasaki University

All 2020 2019 2018 2017 2016 2015 2014 2010 2009 2008 Other

All Journal Article Presentation

[Journal Article] Prion Protein is a Novel Modulator of Influenza: Potential Implications for Anti-Influenza Therapeutics2020
- Author(s)
  Sakaguchi Suehiro、Chida Junji
- Journal Title
  
  Current Issues in Molecular Biology
  
  Volume: 37 Pages: 21-32
- DOI
  10.21775/cimb.037.021
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03548
[Journal Article] The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region.2020
- Author(s)
  Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Junji Chida, Keiji Uchiyama, Kentaro Masujin, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
- Journal Title
  
  Molecular Neurobiology
  
  Volume: 57 Pages: 1203-1216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03548
[Journal Article] Cellular prion protein-mediated protection against influenza A virus infection2019
- Author(s)
  Chida Junji、Sakaguchi Suehiro
- Journal Title
  
  Future Virology
  
  Volume: 14 Pages: 31-37
- DOI
  10.2217/fvl-2018-0146
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-17K19661
[Journal Article] Roles of Prion Protein in Virus Infections.2018
- Author(s)
  Sakaguchi Suehiro、Chida Junji
- Journal Title
  
  DNA Cell Biol.
  
  Volume: 37 Pages: 808-811
- DOI
  10.1089/dna.2018.4402
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K19661
[Journal Article] Prion protein protects mice from lethal infection with influenza A viruses.2018
- Author(s)
  Chida Junji、Hara Hideyuki、Yano Masashi、Uchiyama Keiji、Das Nandita Rani、Takahashi Etsuhisa、Miyata Hironori、Tomioka Yukiko、Ito Toshihiro、Kido Hiroshi、Sakaguchi Suehiro
- Journal Title
  
  PLoS Pathog.
  
  Volume: 14
- DOI
  10.1371/journal.ppat.1007049
- NAID
  120006524496
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07499, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-16H05348, KAKENHI-PROJECT-16K10029, KAKENHI-PROJECT-17K19661
[Journal Article] Structural and mechanistic aspects influencing the ADAM10-mediated shedding of the prion protein2018
- Author(s)
  Linsenmeier Luise、Mohammadi Behnam、Wetzel Sebastian、Puig Berta、Jackson Walker S.、Hartmann Alexander、Uchiyama Keiji、Sakaguchi Suehiro、Endres Kristina、Tatzelt Joerg、Saftig Paul、Glatzel Markus、Altmeppen Hermann C.
- Journal Title
  
  Molecular Neurodegeneration
  
  Volume: 13 Pages: 18-18
- DOI
  10.1186/s13024-018-0248-6
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-17K19661
[Journal Article] 宿主因子を標的にした新たなインフルエンザ治療の試み2018
- Author(s)
  千田淳司、木戸博、坂口末廣
- Journal Title
  
  BIO Clinica
  
  Volume: 33 Pages: 52-55
- Data Source
  KAKENHI-PROJECT-17K19661
[Journal Article] Novel Amplification Mechanism of Prions through Disrupting Sortilin-Mediated Trafficking.2017
- Author(s)
  Suehiro Sakaguchi, Keiji Uchiyama
- Journal Title
  
  Prion
  
  Volume: 11 Pages: 398-404
- DOI
  10.1080/19336896.2017.1391435
- NAID
  120006537522
- Data Source
  KAKENHI-PUBLICLY-17H05701
[Journal Article] Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice2017
- Author(s)
  Hara H, Miyata H, Das NR, Chida J, Yoshimochi T, Uchiyama K, Watanabe H, Kondoh G, Yokoyama T, Sakaguchi S
- Journal Title
  
  Journal of Virology
  
  Volume: -
- DOI
  10.1128/jvi.01368-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K10029, KAKENHI-PUBLICLY-17H05701, KAKENHI-PROJECT-15K21098
[Journal Article] Melanin or a Melanin-Like Substance Interacts with the N-Terminal Portion of Prion Protein and Inhibits Abnormal Prion Protein Formation in Prion-Infected Cells.2017
- Author(s)
  Taichi Hamanaka, Keiko Nishizawa, Yuji Sakasegawa, Ayumi Oguma, Kenta Teruya, Hiroshi Kurahashi, Hideyuki Hara, Suehiro Sakaguchi, Katsumi Doh-ura
- Journal Title
  
  J Virol.
  
  Volume: 印刷中
- DOI
  10.1128/jvi.01862-16
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-16H05317, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K01804
[Journal Article] Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice.2017
- Author(s)
  Nandita Rani Das, Hironori Miyata, Hideyuki Hara, Keiji Uchiyama, Junji Chida, Masashi Yano, Hitomi Watanabe, Gen Kondoh, Suehiro Sakaguchi
- Journal Title
  
  Arc. Virol.
  
  Volume: 印刷中 Pages: 1867-1876
- DOI
  10.1007/s00705-017-3295-3
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560, KAKENHI-PROJECT-26293212, KAKENHI-PROJECT-15K15380, KAKENHI-PROJECT-15K21098, KAKENHI-PROJECT-16K10029
[Journal Article] Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal rResidues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice.2014
- Author(s)
  Uchiyama K, Miyata H, Yano M, Yamaguchi Y, Imamura M, Muramatsu N, Das NR, Chida J, Hara H, Sakaguchi S.
- Journal Title
  
  PLOS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0109737
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25870474, KAKENHI-PROJECT-25870479, KAKENHI-PROJECT-26460557
[Journal Article] Effects of a brain-engraftable microglial cell line expressing anti-prion scFv antibodies on survival times of mice infected with scrapie prions.2010
- Author(s)
  Koji Fujita, Yoshitaka Yamaguchi, suyoshi Mori, Naomi Muramatsu, Takahito Miyamoto, Masashi Yano, Hironori Miyata, Akira Ootsuyama, Makoto Sawada, Haruo Matsuda, Ryuji Kaji , Suehiro Sakaguchi.
- Journal Title
  
  Cellular and Molecular Neurobiology in press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580354
[Journal Article] Cellular prion protein prevents brain damage after encephalomyocarditis virus infection in mice.2008
- Author(s)
  Nasu-Nishimura Y, Taniuchi Y, Nishimura T, Sakudo A, Nakajima K, Ano Y, Sugiura K, Sakaguchi S, Itohara S, Onodera T.
- Journal Title
  
  Arch Virol. 153(6)
  
  Pages: 1007-12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580354
[Journal Article] Dominant-negative effects of the N-terminal half of prion protein on neurotoxicity of prion protein-like rotein/doppel in mice.2008
- Author(s)
  Yoshikawa D, Yamaguchi N, Ishibashi D, Yamanaka H, Okimura N, Yamaguchi Y, Mori T, Miyata H, Shigematsu K, Katamine S, Sakaguchi S.
- Journal Title
  
  J Biol Chem. 283(35)
  
  Pages: 24202-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20580354
[Presentation] プリオン蛋白質はインフルエンザAウイルス感染による重症化を軽減する2019
- Author(s)
  千田　淳司、原　英之、坂口　末廣
- Organizer
  第 42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03548
[Presentation] ウイルス感染を用いたプリオン病発症機構の解明2019
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第 42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19H03548
[Presentation] インフルエンザウイルス感染は神経細胞において異常型プリオン産生のトリガーとなる2018
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第 40回日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-17H05701
[Presentation] インフルエンザウイルス感染は神経細胞において異常型プリオン産生のトリガーとなる2018
- Author(s)
  原　英之、千田　淳司、坂口　末廣
- Organizer
  第 40回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] プリオン蛋白質はインフルエンザAウイルス感染に防御的に機能する2018
- Author(s)
  千田　淳司、原　英之、坂口　末廣
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PUBLICLY-17H05701
[Presentation] プリオン蛋白質はインフルエンザAウイルス感染に防御的に機能する2018
- Author(s)
  千田　淳司、原　英之、坂口　末廣
- Organizer
  第66回日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] 肺で発現する正常プリオン蛋白質の機能解析2017
- Author(s)
  千田淳司、原英之、坂口末廣
- Organizer
  第３２回中国四国ウイルス研究会
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] プリオン蛋白質はインフルエンザAウイルスの感染を制御する2017
- Author(s)
  千田淳司、原英之、坂口末廣
- Organizer
  2017年度生命科学系学会合同年次大会 (ConBio2017)
- Data Source
  KAKENHI-PROJECT-17K19661
[Presentation] Sorting of prion protein and PrPSc accumulation.2016
- Author(s)
  Keiji Uchiyama, Suehiro Sakaguchi
- Organizer
  PRION 2016/Asian Pacific Prion Symposium 2016
- Place of Presentation
  Hitotsubashi Hall, National Center of Science Building, Tokyo（東京都千代田区）
- Year and Date
  2016-05-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] Sorting of prion protein and PrPSc accumulation.2016
- Author(s)
  Keiji Uchiyama, Suehiro Sakaguchi
- Organizer
  PRION 2016/Asian Pacific Prion Symposium 2016
- Place of Presentation
  Hitotsubashi Hall, National Center of Science Building, Tokyo（東京都千代田区）
- Year and Date
  2016-05-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560
[Presentation] Dysfunction of Sortilin by prion infection2016
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道・札幌市）
- Year and Date
  2016-10-23
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン病における異常プリオンの蓄積メカニズム2016
- Author(s)
  内山圭司、坂口末廣
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] 蛋白質凝集体「プリオン」による抗インフルエンザウイルス活性機構の解明2016
- Author(s)
  原英之、千田淳司、坂口末廣
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-15K15380
[Presentation] プリオン病における異常プリオンの蓄積メカニズム2016
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Sorting of prion protein and PrPSc accumulation2016
- Author(s)
  Uchiyama K and Sakaguchi S
- Organizer
  International Prion Congress-Prion 2016
- Place of Presentation
  一橋講堂（東京都・千代田区）
- Year and Date
  2016-05-10
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン病における異常プリオンの蓄積メカニズム2016
- Author(s)
  内山圭司、坂口末廣
- Organizer
  第39回日本分子生物学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PUBLICLY-15H01560
[Presentation] Novel molecular mechanism for accumulation of abnormal prion protein;Inhibition of Sortilin-mediated PrP degradation2015
- Author(s)
  内山圭司、坂口末廣
- Organizer
  第１５回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] プリオン病におけるポストゴルジ小胞輸送障害2015
- Author(s)
  坂口末廣
- Organizer
  革新的医療研究開発で挑む神経変性疾患―プリオン病治験耐性の確立に向けてー
- Place of Presentation
  名古屋国際会議場国際会議室（愛知県名古屋市）
- Year and Date
  2015-02-14
- Invited
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] Mechanism of sortilin-mediated PrP degradation.2015
- Author(s)
  Keiji Uchiyama, Mitsuru Tomita, Suehiro Sakaguchi
- Organizer
  Asian Pacific Prion Symposium 2015
- Place of Presentation
  Ishikawa Ongakudo, Kanazawa, Japan
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-15H01560
[Presentation] Mechanism of sortilin-mediated PrP degradation.2015
- Author(s)
  Keiji Uchiyama, Mitsuru Tomita, Suehiro Sakaguchi
- Organizer
  Asian Pacific Prion Symposium 2015
- Place of Presentation
  Ishikawa Ongakudo, Kanazawa, Ishikawa
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] Novel molecular mechanism for accumulation of abnormal prion protein;Inhibition of Sortilin-mediated PrP degradation2015
- Author(s)
  内山圭司、坂口末廣
- Organizer
  第１５回日本蛋白質科学会年会
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PUBLICLY-15H01560
[Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015
- Author(s)
  内山圭司, 富田満、坂口末廣
- Organizer
  第３８回日本分子生物学会年会　第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] 次世代抗インフルエンザ薬の宿主ターゲット分子の発見とその治療効果2015
- Author(s)
  坂口末廣
- Organizer
  四国地区五大学　新技術説明会
- Place of Presentation
  JST東京本部別館１Fホール（東京・市ヶ谷）
- Year and Date
  2015-11-27
- Data Source
  KAKENHI-PROJECT-15K15380
[Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015
- Author(s)
  内山圭司, 富田満、坂口末廣
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  Fukuoka International Congress Center（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015
- Author(s)
  内山圭司, 富田満、坂口末廣
- Organizer
  第63回日本ウイルス学会学術集会
- Place of Presentation
  Fukuoka International Congress Center（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PUBLICLY-15H01560
[Presentation] プリオン病におけるポストゴルジ小胞輸送障害2015
- Author(s)
  坂口末廣
- Organizer
  革新的医療研究開発で挑む神経変性疾患―プリオン病治験耐性の確立に向けてー
- Place of Presentation
  名古屋国際会議場国際会議室（愛知県・名古屋市）
- Year and Date
  2015-02-14
- Invited
- Data Source
  KAKENHI-PROJECT-25670422
[Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015
- Author(s)
  内山圭司，富田満，坂口末廣
- Organizer
  Biochemistry and Molecular Biology (BMB) 2015 (第38回日本分子生物学会年会、第88回日本生化学会大会　合同大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] 蛋白質感染粒子「プリオン」と細胞内小胞輸送2015
- Author(s)
  坂口末廣
- Organizer
  第8回共同利用・共同研究「酵素学研究拠点」シンポジウム―タンパク質代謝・分解系の酵素学―
- Place of Presentation
  徳島大学藤井節郎記念ホール（徳島県徳島市）
- Year and Date
  2015-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] Analysis of roles of N-terminal region of prion protein in the conversion into scrapie form by using prion-knockout cell.2015
- Author(s)
  Tomita M, Uchiyama K, Usui T and Sakaguchi S
- Organizer
  Asia Pacific Prion symposium
- Place of Presentation
  Ishikawa Ongakudo, Kanazawa, Japan
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染により過剰な異常プリオンが蓄積する分子メカニズム2015
- Author(s)
  内山圭司、富田満、坂口末廣
- Organizer
  第３８回日本分子生物学会年会　第８８回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PUBLICLY-15H01560
[Presentation] Inhibition of Sortilin-mediated PrP degradation by prion infection causes excessive accumulation of abnormal prion protein.2015
- Author(s)
  Uchiyama K, Tomita M and Sakaguchi S
- Organizer
  第63回日本ウイルス学会学術集会ワークショップ「Prions」
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Year and Date
  2015-11-22
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Novel molecular mechanism for accumulation of abnormal prion protein - Inhibition of Sortilin-mediated PrP degradation.2015
- Author(s)
  Uchiyama K and Sakaguchi S
- Organizer
  第15回蛋白質科学会年会ワークショップ「New development of prion biology」
- Place of Presentation
  あわぎんホール（徳島県徳島市）
- Year and Date
  2015-06-24
- Invited
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] Mechanism of Sortilin-mediated PrP degradation.2015
- Author(s)
  Uchiyama K, Tomita M and Sakaguchi S
- Organizer
  Asia Pacific Prion symposium
- Place of Presentation
  Ishikawa Ongakudo, Kanazawa, Japan
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] 異なるプリオン株に異なる感受性を示すプリオン蛋白:プリオン株産生メカニズムについての考察2010
- Author(s)
  坂口末廣、宮田博規、山口仁孝、村松直美、森剛志
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-20580354
[Presentation] プリオン蛋白構造変換におけるアミノ酸91-104領域の役割2010
- Author(s)
  山口仁孝、村松直美、森剛志、坂口末廣
- Organizer
  第58回日本ウイルス学会学術集会
- Place of Presentation
  徳島
- Year and Date
  2010-11-07
- Data Source
  KAKENHI-PROJECT-20580354
[Presentation] プリオン蛋白オクタペプチドリピート領域はプリオンの病原性を決定する2009
- Author(s)
  宮田博規、山口仁孝、坂口末廣
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-20580354
[Presentation] プリオン構造変換に関与するN末端領域の機能解析2009
- Author(s)
  山口仁孝、村松直美、藤田浩司、坂口末廣
- Organizer
  第57回日本ウイルス学会学術集会
- Place of Presentation
  東京
- Year and Date
  2009-10-25
- Data Source
  KAKENHI-PROJECT-20580354
[Presentation] Post-Golgi trafficking of membrane proteins impaired by prion infection.
- Author(s)
  Uchiyama K. and Sakaguchi S.
- Organizer
  International Prion Congress-Prion 2014
- Place of Presentation
  Trieste, Italy
- Year and Date
  2014-05-27 – 2014-05-30
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染によるポストゴルジ小胞輸送障害
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第66回日本細胞生物学会大会
- Place of Presentation
  奈良県新公会堂（奈良県奈良市）
- Year and Date
  2014-06-11 – 2014-06-13
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオンによるポストゴルジ膜輸送障害
- Author(s)
  坂口末廣、内山圭司
- Organizer
  第３６回生体膜と薬物の相互作用シンポジウム「生体膜における蛋白質の機能制御システムと疾患」
- Place of Presentation
  徳島大学蔵本キャンパス　大塚講堂、藤井節郎記念ホール（徳島県徳島市）
- Year and Date
  2014-11-20 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] 新規プリオン結合因子Sortilinのプリオン感染における役割
- Author(s)
  内山圭司，富田満，臼井健，坂口末廣
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染と小胞輸送障害
- Author(s)
  内山圭司, 坂口末廣
- Organizer
  第87回日本生化学会, シンポジウム　認知症克服に向けて：プリオン病をもっと知る
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26293212
[Presentation] Prions disturb post-Golgi membrane trafficking to the cell surface.
- Author(s)
  Uchiyama K. and Sakaguchi S.
- Organizer
  The 9th International Symposium of the Institute Network
- Place of Presentation
  大阪大学（大阪府吹田市）
- Year and Date
  2014-06-19 – 2014-06-20
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染と小胞輸送障害
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第87回日本生化学会大会シンポジウム「認知症克服に向けて：プリオン病をもっと知る」
- Place of Presentation
  京都国際会館（京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] 新規プリオン結合因子Sortilinのプリオン感染における役割
- Author(s)
  内山圭司, 富田満、臼井健、坂口末廣
- Organizer
  第6２回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜会議センター（神奈川県・横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25670422
[Presentation] プリオンノックアウト細胞を用いたプリオンタンパク質Ｎ末端領域の異常プリオン形成における役割の解明
- Author(s)
  富田満，臼井健，内山圭司，坂口末廣
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす
- Author(s)
  内山圭司、坂口末廣
- Organizer
  第29回中国四国ウイルス研究会
- Place of Presentation
  山口大学吉田キャンパス（山口県・吉田）
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-25670422
[Presentation] プリオン感染と小胞輸送障害
- Author(s)
  内山圭司, 坂口末廣
- Organizer
  第87回日本生化学会, シンポジウム　認知症克服に向けて：プリオン病をもっと知る
- Place of Presentation
  国立京都国際会館（京都府・京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Invited
- Data Source
  KAKENHI-PROJECT-25670422
[Presentation] プリオン感染によるSortilin発現低下が異常プリオン蓄積を引き起こす
- Author(s)
  内山圭司，坂口末廣
- Organizer
  第29回中国四国ウイルス研究会
- Place of Presentation
  山口大学（山口県山口市）
- Year and Date
  2014-06-28 – 2014-06-29
- Data Source
  KAKENHI-PROJECT-26460557
[Presentation] プリオンによるポストゴルジ膜輸送障害
- Author(s)
  坂口末廣，内山圭司
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島大学（徳島県徳島市）
- Year and Date
  2014-11-20 – 2014-11-21
- Invited
- Data Source
  KAKENHI-PROJECT-26460557

1. KATAMINE Shigeru (40161062)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. SHIGEMATSU Kazutio (20154205)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. HARA Hideyuki (40469953)

# of Collaborated Projects: 4 results

# of Collaborated Products: 14 results
4. YANO Masashi (10531858)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. NIWA Msaki (20136641)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. SHIRABE Susumu (40264220)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 千田淳司 (20437651)

# of Collaborated Projects: 2 results

# of Collaborated Products: 8 results
8. YAMAGUCHI Yoshitaka (90432765)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
9. KATAOKA Yasufumi (70136513)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. UEDA Hiroshi (00145674)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. INOUE Makoto (60380987)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. FUJITA Ryousuke (70380855)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. UCHIYAMA Keiji (60294039)

# of Collaborated Projects: 1 results

# of Collaborated Products: 17 results
14. 宮本勉 (10004582)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 水野恭伸 (40311865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉田明 (70257187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. DERI Maria.A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TERUYA Kenta

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
19. NISHIZAWA Keiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
20. OGUMA Ayumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
21. SAKASEGAWA Yuji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
22. 高橋悦久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
23. 木戸博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
24. 渡邊仁美

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
25. 堂浦克美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sakaguchi Suehiro 坂口 末廣

SAKAGUCHI Suehiro 坂口 末廣

Research Projects

Research Products

Co-Researchers

Elucidation of the pathogenic mechanism and screening of therapeutic compounds in prion diseasePrincipal InvestigatorOngoing

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Prion protein is a target molecule for a novel anti-influenza therapeuticPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プリオン以外のプリオン病の病原体の同定とその病原性メカニズムの解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of our recent findings on the protective role of prion protein against lethal infection with influenza A viruses is useful for development of a new type of anti-influenza drugsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プリオンの増殖と病原性獲得に重要なプリオンの細胞内移動に関与する分子の同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the vesicular trafficking mechanism for prion propagation on the basis of our previous findings of the disturbed vesicular trafficking in prion diseasePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of basic technology for therapy of prion diseases based on Sortilin function

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Identification of a host molecule inportant for prion infectionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The development of a ultra-sensitive diagnostic technique for BSE(Mad cow disease)

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of a signaling pathway of prion protein in neuronal cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プリオン病における神経細胞変性死の分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional proteomics analysis of non-vesicular release mechanisms in stress exposed neuron-role of stress-induced non-vesicular release Prion, NDI and FGF-1 in neuron

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

プリオン病における神経細胞変性死の分子機構解明Principal Investigator

Principal Investigator

Project Period (FY)

Sakaguchi Suehiro 坂口末廣

SAKAGUCHI Suehiro 坂口末廣