SEKIGUCHI Mutsuo 関口睦夫

Researcher Number	00037342
Other IDs
Affiliation (based on the past Project Information) *help	2017 – 2018: 福岡歯科大学, 口腔歯学部, 客員教授 2016: 福岡歯科大学, 口腔歯学部, 教授 2015: 福岡歯科大学, 歯学部, 教授 2014: 福岡歯科大学, 口腔歯学部, 教授 2010 – 2013: 福岡歯科大学, 歯学部, 教授 … More
Review Section/Research Field	Principal Investigator Biological Sciences / Genetics/Genome dynamics / Molecular biology / 遺伝 Except Principal Investigator Biological Sciences / Cell biology / Molecular biology / Pathobiological dentistry/Dental radiology / Risk sciences of radiation and chemicals / Genetics/Chromosome dynamics / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 突然変異 / DNA修復 / アルキル化剤 / 発がん / 遺伝子欠損マウス / 遺伝子ターゲティング / DNA修復酵素 / 自然突然変異 / 活性酸素 / 遺伝子 … More Except Principal Investigator DNA修復 / アルキル化剤 / 突然変異 / トランスポゾン / シャフロン / 細胞周期 / 活性酸素 / リン酸レギュロン / DNA repair / 細胞死 / 酸化ストレス / 大腸菌 / GC含量 / dGTPase / 減数分裂期組換え / RecA蛋白質 / M期 / 標的遺伝子組換え / 転写 / 遺伝子 / 癌 / 適応応答 / 走性 / SOS応答 / 熱ショック応答 / 自然突然変異 / 細胞複製 / DNA / がん遺伝子 / がん抑制遺伝子 / シグナル伝達 / がん細胞 / がん転移 / ヒトゲノム / 2国間共同研究 / DNA Repair / 非相同組換え / DNAヘリカーゼ / 遺伝子ターゲッティング / Transposon / Illegitimate recombination / G0 / G1 / DNA複製 / cdc2 / 色素性乾皮症 / ミスマッチ修復 / ノックアウトマウス / 発がん / xeroderma pigmentosum / knockout mice / apoptosis / アポトーシス / 酸化ヌクレオチド / ミュ-テ-タ- / DNAポリメラ-ゼIII / 組換え酵素、 / 染色体分配と組換え、 / 細胞分化と遺伝子の再編成、 / 性特異的組換え / 普偏的組換え、 / 部位特異的組換え、 / トランスポゾン、 / 遺伝子タ-ゲッティング、 / メチルトランスフェラ-ゼ / cDNAクロ-ニング / Mer形質 / DNA修復酵素 / 遺伝子クロ-ニング / 化学発癌 / 遺伝的組換えの分子機構 / 遺伝子タ-ゲッティング / 組換えのホットスポット / 組換え酵素 / G1期 / S期 / G2期 / 染色体凝縮 / 標的組換え / マウスゲノム / ヒト疾患モデル / ゼブラフィッシュ / ニワトリ / 遺伝子欠損マウス / 標的遺伝子組替え / ジーンターゲッテイング / ドーパミン受容体 / H-ras / N-ras / K-ras / セロトニン受容体 / バイオサイエンス / ジーンターゲッティング / myogenin / tau / グルタミン酸受容体 / p53 / GFAP / DNAトランスアクション / 遺伝情報維持 / 複製 / 修復 / 組換え / 核酸 / ゲノム / 動物 / 消化管 / DNA修複酵素 / 組換えDNA実験 / 形質発現 / 遺伝子の構造 / 生体機能 / 変異ひん度 / ミューテーター遺伝子 / DNAポリメラーゼ / エキソヌクレアーゼ / A:T→C:G特異的なトランスバージョン / 染色体 / 総括班 / 公開シンポジウム / ワークショップ / 転写調節 / べん毛レギュロン / SOS誘導 / 刺激応答 / 染色体の複製 / 細胞質の複製 / 細胞表層の複製 / 分裂装置 / ミューテーター / トランスバージョン / 立体異性体 / 肝細胞癌 / 中国 / 疫学 / 癌遺伝子 / 一次トランスフォ-マント / 二次トランスフォ-マント / Hepatocellular carcinoma / China / Epidemiology / Oncogene / Primary transformant / Secondary transformant / がん遣伝子 / がん抑制遣伝子 / International Exchange Program / French-Japanese Collaborative Program in Cancer Research / German-Japanese Collaborative Program in Cancer Research / Oncogenes / Tumor Suppressor Genes / Signal Transduction / Cancer Metastasis / 組換えホットスポット / トランスポゾン転移酵素 / 標的遺伝子破壊 / ホリデ-構造開裂酵素 / 抗体受容体遺伝子再構成 / プラスミドシャフロンのDNA逆位 / 組み換えホットスッポット / 抗原受容体遺伝子再構成 / 相同的組換え / ジャイレース依存の組換え / 部位特異的組換え / Genetic recombination / RecA protein / RecA homologues / Rad51 protein / Shufflon / Recombination hot spot / 若い研究者の独立 / 独創的研究 / 研究のフロンティア / 窒息的な現状 / 日米比較 / アメリカの科学の底力 / 新しい組織の模索 / ライフサイエンス / ライフサイエンスセンター構想 / ウイルス研分館構想 / 民間資金 / 研究高度化 / 教育・研究体制の再編成 / difference in US and Japanese systems / independence of young scientists / "choking" status of Japanese research organization / creative research / life science / strenght of American science / a reform of Japanese system / frontier of research / MAPキナーゼ / サイクリン / ユビキチン / Gタンパク / コビキチン / 染色体分配 / G2 / M / ライセンス因子 / プロテアソーム / DNA replication / Mitosis / Map Kinase / Cycline / Ubiquitin / G protein / 遺伝子クローニング / 光回復酵素 / X線構造解析 / 遺伝子ターゲティング / p53蛋白質 / モデルマウス / DNA結合 / gene cloning / photolyases / X-ray crystallography / mismatch repair / gene targeting / 細胞増殖 / 細胞分化 / 細胞間相互作用 / ヒトがん / cell growth / cell differentiation / signal transduction / cell-cell interaction / cancer metastasis / human cancer / oncogene / tumor suppressor gene / エンドジョイニング / 動く遺伝子 / トラシスポゾン / 転移 / 遺伝子スイッチ / 遺伝子ホーミング / 遺伝病 / DNA二本鎖切断 / DNAエンドジョイニング / 遺伝的組換え / トランスポゼース / ブルーム症候群 / DNAの切断と再結合 / RecQヘリカーゼ / DNA切断再結合 / エンドヌクレアーゼ / DNA end-Joining / Mobile genetic elements / Transposition / Shaffron / Gene homing / Bloom syndrome / 転写と共役した修復 / ゲノム全体の修復 / コケイン症候群 / 熱力学 / ユビキチン化 / 損傷乗り越え複製 / ユビキチンリカーゼ / レーザー / 損傷トレランス / ユビキチンリガーゼ / 機能的プロテオーム / 損傷乗り越え修復 / DNA損傷トレランス / 紫外線 / DNA損傷 / 複製後修復 / 核マトリクス / DNA修復ネットワーク / チミングリコール / 転写伸長 / XPA / NTH1 / リン酸化 / DNA damage / Cockayne syndrome / postreplication repair / nuclear matrix / transcription / DNA酸化損傷 / 酸化グアニン / 自然発がん / DNA oxidation / Spontaneous mutation / oxidation of guanine nucleotides / Spontaneous carcinogenesis / アポソーシス / O^6-メチルグアニン / 抗がん剤 / mutation / alkylated agent / RNA 酸化 / ８ーオキソグアニン / ヌクレオチド代謝 / ノックアウト細胞株 / 酸化RNA / 8-オキソグアニン / RNAの分解 / Auf1 / mutT / Mth1 / 網羅的 / 異常タンパク / 老化 / Carcinogenesis / ROS / human iPS cell / Mitochondria / ヒトiPS細胞 Less

内在性酸化ストレス制御による発がん初期シグナル分子の同定Ongoing
- Principal Investigator
  
  岡素雅子
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Fukuoka Dental College
活性酸素により生じた変異誘発物質の排除機構
- Principal Investigator
  
  早川浩
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Chromosome dynamics
- Research Institution
  Fukuoka Dental College
Cell death mechanism by RNA oxidative signal transduction
- Principal Investigator
  
  Sekiguchi Takeshi
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Risk sciences of radiation and chemicals
- Research Institution
  Kyushu University
Novel mechanisms for eliminating oxidatively damaged RNAPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Fukuoka Dental College
Genetic system for functioning to prevent agingPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Fukuoka Dental College
Mechanisms for quality control of RNA in mammalian cellsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Fukuoka Dental College
酸化ストレス誘発発がんの抑制に関与する分子機構
- Principal Investigator
  
  TSUZUKI Teruhisa
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Kyushu University
The mechanism of cell death inducedby O^6-methylguanine DNA : the role of MSH2 and MLH1 proteins
- Principal Investigator
  
  ITO Riyoko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Fukuoka Dental College
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotides
- Principal Investigator
  
  TAKAGI Yasumitsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
発がん抑制におけるDNA修復とアポトーシスの役割Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka Dental College
発がん抑制におけるミスマッチ遺伝子の役割Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka Dental College
DNA damage-induced cell death and DNA repair network
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  2000 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Osaka University
Development of a detection and evaluation system for carcinogens with the use of cell lines deficient in DNA repair genesPrincipal Investigator
- Principal Investigator
  
  ITOH Riyoko, 関口睦夫
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  遺伝
- Research Institution
  Fukuoka Dental College
発がん抑制におけるミスマッチ修復の役割Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Fukuoka Dental College
Mechanisms for control of spontaneous mutagenesis as revealed by the use gene-targeted micePrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  遺伝
- Research Institution
  Fukuoka Dental College
Regulatory mechanisms for mutagenesis and carcinogenesisPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
発がん抑制における突然変異制御遺伝子の役割Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Fukuoka Dental College
Novel developments on genetic recombination : DNA double-strand break and DNA end-joining
- Principal Investigator
  
  OHTSUBO Eichi, 池田日出男
- Project Period (FY)
  1998 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Kitasato Institute
標的遺伝子組換えによる生体機能の研究
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
  Kyushu University
酸素による遺伝子障害とその防御機構Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fukuoka Dental College
発がんにおける突然変異制御遺伝子系の役割Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Fukuoka Dental College
Repair of alkylation DNA damagePrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
Detection-evaluation systems for carcinogens with the use of gene-defective micePrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
Mechanism for control of mutagenesis in mammalsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  遺伝
- Research Institution
  Fukuoka Dental College
Active Oxygen-induced DNA Damage and its Repair MechanismsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
DNAトランスアクションと遺伝情報の安定性
- Principal Investigator
  
  花岡文雄
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Cell biology
- Research Institution
  Osaka University
Cooperation and information exchange with European countries.
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Showa University
  The University of Tokyo
Oxygen-induced DNA Damage and its Repair MechanismsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
Mechanisms os spontaneous mutation and its controlPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka Dental College
  Kyushu University
cell cycle regulation
- Principal Investigator
  
  NISHIMOTO Takeharu
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  KYUSHU UNIVERSITY
Molecular Mechanism for Maintainance of Genetic Information
- Principal Investigator
  
  TANAKA Kiyoji
- Project Period (FY)
  1993 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞周期制御のネットワーク
- Principal Investigator
  
  NISHIMOTO Takeharu
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Kyushu University
標的遺伝子組換えによる生体機能の研究
- Principal Investigator
  
  勝木元也
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Kyushu University
A study on new Virology as a dirving force of life science
- Principal Investigator
  
  HATANAKA Masakazu
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Institution
  KYOTO UNIVERSITY
cDNA発現ベクタ-を用いた高発癌性遺伝病の遺伝子クロ-ニングと解析
- Principal Investigator
  
  HAYAKAWA Hiroshi
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
生体機能における組換えの基本機構
- Principal Investigator
  
  小川英行
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
Cooperation and information exchange with European countries.
- Principal Investigator
  
  KUROKI Toshio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  University of Tokyo
Mechanisms of mutagenesis and maintenance of genetic information in mammalian cellsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyushu University
Basic Mechanisms of Genetic Recombination
- Principal Investigator
  
  OGAWA Hideyuki
- Project Period (FY)
  1991 – 1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
遺伝的組換えの分子機構に関する調査研究
- Principal Investigator
  
  OGAWA Hideyuki
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Institution
  Osaka University
Molecular mechanisms of the adaptive response to alkylating agentsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  KYUSHU UNIVERSITY
染色体GC含量を制御するミュ-テ-タ-遺伝子(mut T)の分子遺伝学的研究
- Principal Investigator
  
  堀内嵩
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Study on Oncogene in Juvenile Hepatocellular Carcinoma in China
- Principal Investigator
  
  NAKAYAMA Fumio
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Kyushu University
染色体GC含量を制御するミューテーター遺伝子(mutT)の分子遺伝学的研究
- Principal Investigator
  
  堀内嵩
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Mechanisms for induction and suppression of spontaneous and induced mutationsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for Overseas Scientific Survey.
- Research Institution
  Kyushu University
細胞複製の分子遺伝学的展開
- Principal Investigator
  
  吉川寛
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
細胞複製の分子遺伝学的展開
- Principal Investigator
  
  吉川寛
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Osaka University
ヨーロッパなどがん研究先進国との研究交流
- Principal Investigator
  
  豊島久真男
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Overseas Scientific Research
- Research Institution
  The University of Tokyo
刺激応答の遺伝的制御系
- Principal Investigator
  
  飯野徹雄
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
がん原性DNA変異野の生起とその抑制機構
- Principal Investigator
  
  堀内嵩
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyushu University
刺激応答の遺伝的制御系
- Principal Investigator
  
  飯野徹雄
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
刺激応答の遺伝的制御系
- Principal Investigator
  
  飯野徹雄
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  The University of Tokyo
Maintenance of Genetic Information and Mutagenesis MechanismsPrincipal Investigator
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1986 – 1990
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Research Institution
  Kyushu University
アルキル化剤によるがん原性DNA変異の生起とその抑制機構Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
DNAによる形質転換を利用したヒトや哺乳動物の遺伝子の解析Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyushu University
がん原性DNA変異の生起とその抑制機構Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1985
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyushu University
アルキル化剤によるがん原性DNA変異の生起とその抑制機構Principal Investigator
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  1984 – 1986
- Research Category
  
  Grant-in-Aid for Cancer Research
- Research Institution
  Kyushu University
組換えDNAの発現と生体機能
- Principal Investigator
  
  高木康敬
- Project Period (FY)
  1983 – 1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Fujita Health University

All 2019 2018 2017 2016 2015 2013 2012 2011 2007 2006 2005 2004 Other

All Journal Article Presentation Book

[Book] Oxidative Stress, Disease and Cancer, (Singh, K K (Ed))2006
- Author(s)
  Nakatsu Y., Sekiguchi, M.
- Publisher
  World Scientific Publishing Co., New York (In press)
- Data Source
  KAKENHI-PROJECT-17013068
[Journal Article] ROS control in human iPS cells reveals early events in spontaneous carcinogenesis2019
- Author(s)
  Sugako Oka, Michio Hayashi, Kenichi Taguchi, Masumi Hidaka, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Journal Title
  
  Carcinogenesis
  
  Volume: 印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07250
[Journal Article] Function of high-mobility group A proteins in the DNA damage signaling for the induction of apoptosis.2016
- Author(s)
  Fujikane, R., Komori, K., Sekiguchi, M., Hidaka, M.
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Pages: 31714-31714
- DOI
  10.1038/srep31714
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-26340040, KAKENHI-PROJECT-26830085
[Journal Article] Nucleotide excision repair of oxidized genomic DNA is not a source of urinary 8-oxo-7,8-dihydroguanosine.2016
- Author(s)
  Evans, M. D., Misty, V., Singh, R., Gackowski, D., Rozalski, R., Siomek, A., Phillips, D. H., Zuo, J., Mullenders, L., Pines, A., Nakabeppu, Y., Sakumi, K., Sekiguchi, M., Tsuzuki, T., Bignami, M., Farmer, P. B., Oliski, R., Cooke, M. S.
- Journal Title
  
  Free Radic Biol Med
  
  Volume: 99 Pages: 358-391
- DOI
  10.1016/j.freeradbiomed.2016.08.018
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25241012, KAKENHI-PROJECT-15H04298, KAKENHI-PROJECT-16H05109, KAKENHI-PROJECT-26340040, KAKENHI-PROJECT-16K12605
[Journal Article] Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells2015
- Author(s)
  Takashi Ishii, Hiroshi Hayakawa, Takeshi Sekiguchi, Noritaka Adachi, Mutsuo Sekiguchi
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 79 Pages: 109-116
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Role of Auf1 in elimination of oxidatively damaged messenger RNA in human cells2015
- Author(s)
  Ishii T, Hayakawa H, Sekiguchi T, Adachi N, Sekiguchi M.
- Journal Title
  
  ree Radical Biology and Medicine
  
  Volume: 79 Pages: 109-116
- DOI
  10.1016/j.freeradbiomed.2014.11.018
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24310149, KAKENHI-PROJECT-24570160, KAKENHI-PROJECT-26340040, KAKENHI-PROJECT-26670031
[Journal Article] Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues2013
- Author(s)
  Ben Nie, Wei Gan, Fei Shi, Guo-Xin Hu, Lian-Guo Chen, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai
- Journal Title
  
  Oxidative Medicine and Cellular Longevity
  
  Volume: 2013 Pages: 1-9
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Search for Proteins Required for Accurate Gene Expression under Oxidative Stress: Roles of Guanylate Kinase and RNA Polymerase.2013
- Author(s)
  Hchiro Inokuchi, Riyoko Ito, Tkeshi Sekiguchi, Mutsuo Skiguchi
- Journal Title
  
  J Biol. Chem.
  
  Volume: 288 Pages: 32952-32962
- DOI
  10.1074/jbc.m113.507772
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003, KAKENHI-PROJECT-24570160
[Journal Article] Age-dependent accumulation of 8-oxoguanine in the DNA and RNA in various rat tissues2013
- Author(s)
  Ben Nie, Wei Gan, Fei Shi, Guo-Xin Hu, Lian-Guo Chen, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai
- Journal Title
  
  Oxidative medicine and Cellular longevity
  
  Volume: 2013 Pages: 1-9
- DOI
  10.1155/2013/303181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003, KAKENHI-PROJECT-24657006
[Journal Article] Search for proteins required for accurate gene expression under oxidative stress : Roles of guanylate kinase and RNA polymerase2013
- Author(s)
  Hachiro Inokuchi, Riyoko Ito, Takeshi Sekiguchi, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 32952-32962
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Stablization of MAPO1 by specific birding with folliculir and AMP-activated protein kinase in O6-methylguanine-induced apoptosis2013
- Author(s)
  Shiori Sano, Ryuji Sakagami, Mutsuo Sekiguchi, Masumi Hidaka
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 430 Pages: 810-815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors2013
- Author(s)
  Takeshi Sekiguchi, Riyoko Ito, Hiroshi Hayakawa, Mutsuo Sekiguchi
- Journal Title
  
  I. Biol. Chem.
  
  Volume: 288 Pages: 8128-8135
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors2013
- Author(s)
  Takeshi Sekiguchi, Riyoko Ito, Hiroshi Hayakawa, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 8128-8135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Elimination and utilization of oxidized guanine nucleotides in the synthesis of RNA and its precursors2013
- Author(s)
  Takeshi Sekiguchi, Riyoko Ito, Hiroshi Hayakawa, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 288 Pages: 8128-8135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Stablization of MAPO1 by specific birding with folliculir and AMP-activated protein kinase in O6-methylguanine-induced apoptosis2013
- Author(s)
  Shiori Sano, Ryuji Sakagami, Mutsuo Sekiguchi, Masumi Hidaka
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 430 Pages: 810-815
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Human MTH3(NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosplate: Comparison with MTH1 and MTH22012
- Author(s)
  Yasumitsu Takagi, Daiki Setoyama, Riyoko Ito, Hiroshi Ｈａｙａｋａｗａ, Hiroyuki kamiya, Yuriko Yamagata, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 21541-21549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] My Path toward DNA repair2012
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  DNA Repair
  
  Volume: 11 Pages: 606-615
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] My path toward DNA repair2012
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  DNA Repair
  
  Volume: 11 Pages: 606-615
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Human MTH3(NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosplate: Comparison with MTH1 and MTH22012
- Author(s)
  Yasumitsu Takagi, Daiki Setoyama, Riyoko Ito, Hiroshi Ｈａｙａｋａｗａ, Hiroyuki kamiya, Yuriko Yamagata, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 21541-21549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Age-dependent increasers in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analyzed by LC-MS/MS : Urinary 8-oxoguanine as a novel biomarker of aging2012
- Author(s)
  Wei Gan, Ben Nie, Fei Shi, Xin-Min Xu, Chan Qian, Yasumitsu Takagi, Hiroshi Hayakawa, Mutuo Sekiguchi, Jian-Ping Cai
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 52 Pages: 1700-1707
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Age-dependent increasers in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analized by LC-MS/MS: Urinary 8-oxoguanine as a novel biomaker of aging2012
- Author(s)
  Wei Gan, Ben Nie, Fei Shi, Xin-Min Xu, Jian-Chan Qian, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 52 Pages: 1700-1707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] MAPO1とFLCNによるAMPKの活性化はアルキル化損傷に起因するアポトーシスを誘導する2012
- Author(s)
  T.H.Lim, R.Fujikane, S.Sano, R.Sakagami, Y.Nakatsu, T.Tsuzuki, M.Sekiguchi, M.Hidaka
- Journal Title
  
  DNA Repair
  
  Volume: 11 Pages: 259-266
- DOI
  10.1016/j.dnarep.2011.11.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003, KAKENHI-PROJECT-22659346, KAKENHI-PROJECT-23701065
[Journal Article] Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphate : Comparison with MTH1 and MTH22012
- Author(s)
  Yasumitsu Takagi, Daiki Setoyama, Riyoko, Ito, Hiroshi Hayakawa, Hiroyuki Kamiya, Yuriko Yamagata, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 21541-21549
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Age-dependent increasers in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analized by LC-MS/MS: Urinary 8-oxoguanine as a novel biomaker of aging2012
- Author(s)
  Wei Gan, Ben Nie, Fei Shi, Xin-Min Xu, Jian-Chan Qian, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 52 Pages: 1700-1707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Stabilization of MAPO1 by specific binding with follicular and AMP-activated protein kinase in O^6-methylguanine-induced apoptosis2012
- Author(s)
  Shiori Sano, Ryuji Sakagami, Mutsuo Sekiguchi, Masumi Hidaka
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 430 Pages: 810-815
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] The identification of novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O^6-methylguanine2012
- Author(s)
  Ryosuke Fujikane, Masayuki, Sanada, Mutsuo Sekiguchi, Masumi Hidaka
- Journal Title
  
  PLoS ONE
  
  Volume: 7
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] The identification of novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O6-methylguanine2012
- Author(s)
  Ryosuke Fujikane, Masauki Sanada, Mutsuo Sekiguchi, Masumi HIdaka
- Journal Title
  
  PLOS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] The identification of novel gene, MAPO2, that is involved in the induction of apoptosis triggered by O6-methylguanine2012
- Author(s)
  Ryosuke Fujikane, Masauki Sanada, Mutsuo Sekiguchi, Masumi HIdaka
- Journal Title
  
  PLOS ONE
  
  Volume: 7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24657006
[Journal Article] Oxidative damage to RNA and expression patterns of MTH1 in the hippocampi of senescence-accelerated SAMP8 mice and Alzheimse's disease patients2011
- Author(s)
  X.-N.Song, L.-Q.Zhang, D.-G.Liu, J.Lin, J.-D.Zheng, D.-P.Dai, A.-L.Hei, H.Hayakawa, M.Sekiguchi, J.-P.Cai
- Journal Title
  
  Neurochem.Res.
  
  Volume: 36 Pages: 1558-1565
- DOI
  10.1007/s11064-011-0484-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Diverse substraterecognition and hydrolysis mechanisms ofhuman NUDT52011
- Author(s)
  Takao Arimori, at al
- Journal Title
  
  Nucleic Acids Research
  
  Volume: 39 Pages: 8972-8983
- DOI
  10.1093/nar/gkr575
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131007, KAKENHI-PROJECT-22370003, KAKENHI-PROJECT-22570007, KAKENHI-PUBLICLY-23121523, KAKENHI-PROJECT-23790052
[Journal Article] Molecular devices for high fidelity of DNA replication and gene expression2006
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  Prc.Japan Acad., Ser.B 52・8
  
  Pages: 278-296
- NAID
  130000093838
- Data Source
  KAKENHI-PROJECT-18370005
[Journal Article] Molecular devices for high fidelity of DNA replication and gene expression2006
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  Proc.Japan Acad., Ser.B 52-8
  
  Pages: 278-296
- NAID
  130000093838
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370005
[Journal Article] Molecular devices for high fidelity of DNA replication and gene expression.2006
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  Proc. Japan Acad., Ser. B 52
  
  Pages: 278-296
- NAID
  130000093838
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Journal Article] A quest to understand mechanisms for genetic stability.2006
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  DNA Repair 5
  
  Pages: 6750-6755
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Journal Article] A quest to understand mechanisms for genetic stability2006
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  DNA Repair 5
  
  Pages: 6750-6755
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370005
[Journal Article] A quest to understand molecular mechanisms for genetic stability2006
- Author(s)
  Mutsuo Sekiguchi
- Journal Title
  
  DNA Repair 5
  
  Pages: 750-6755
- Data Source
  KAKENHI-PROJECT-18370005
[Journal Article] Mammalian enzymes for preventing transcriptional errors caused by oxidative damage2005
- Author(s)
  Ishibashi T, Hayakawa H, Ito R, Miyazawa M, Yamagata Y, Sekiguchi M.
- Journal Title
  
  Nucleic Acids Res. 33(12)
  
  Pages: 3779-3784
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools.2005
- Author(s)
  Ito, R., Hayakawa, H., Sekiguchi, M., Ishibashi, T.
- Journal Title
  
  Biochemistry 44・17
  
  Pages: 6670-6674
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells2005
- Author(s)
  Hidaka M, Takagi Y, Takano TY, Sekiguchi M.
- Journal Title
  
  Nucleic Acids Res. 33(17)
  
  Pages: 5703-5712
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Mammalian enzymes for preventing transcriptional errors caused by oxdative damage.2005
- Author(s)
  Ishibashi, T., Hayakawa, H., Ito, R., Miyazawa, M., Yamagata, Y., Sekiguchi, M.
- Journal Title
  
  Nucleic Acid research 33・12
  
  Pages: 3779-3784
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] PCNA/MutSa-mediated binding of MutLα to replicative DNA with mismatched base to induce apoptosis in human cells.2005
- Author(s)
  Hidaka, M., Y.Takagi, Y.T.Takano, M.Sekiguchi
- Journal Title
  
  Nucleic Acid Research 33・17
  
  Pages: 5703-5712
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Multiple enzyme activities of Escherichia coli MutT protein for sanitization of DNA and RNA precursor pools2005
- Author(s)
  Ito R, Hayakawa H, Sekiguchi M, Ishibashi T.
- Journal Title
  
  Biochemistry 44(17)
  
  Pages: 6670-6674
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Mammalian enzymes for preventing transcriptional errors caused by oxdative damage.2005
- Author(s)
  Ishibashi, T., Hayakawa, H., Ito, R., Miyazawa, M., Yamagata, Y., Sekiguchi, M.
- Journal Title
  
  Nucleic Acid Research 33・12
  
  Pages: 3779-3784
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells : effects of Mgmt and Mlh1 mutations2004
- Author(s)
  Sanada M, Takagi Y, Ito R, Sekiguchi M.
- Journal Title
  
  DNA Repair 3
  
  Pages: 413-420
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells : effects of Mgmt and Mlh1 mutations.2004
- Author(s)
  Sanada, M., Takagi, Y., Ito, R., Sekiguchi, M.
- Journal Title
  
  DNA Repair 3
  
  Pages: 413-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Presentation] Establishment of cancer cell models derived from human iPS cells based on mitochondrial complex II deficiency2018
- Author(s)
  Sugako Oka, Michio Hayashi, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Organizer
  第77回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] Establishment of cancer cell models derived from human iPS cells based on mitochondrial complex II deficiency2018
- Author(s)
  Sugako Oka, Michio Hayashi, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Organizer
  北京シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] ミトコンドリア複合体II不全によるヒトiPS細胞由来発がんモデルの構築2018
- Author(s)
  岡素雅子、林道夫、関口睦夫
- Organizer
  JEMS公開シンポジウム(日本環境変異学会主催)、「＜若手企画＞遺伝毒性研究の最前線と挑戦」
- Invited
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] ミトコンドリア複合体II不全によるヒトiPS細胞由来発がんモデルの構築2018
- Author(s)
  岡素雅子、林道夫、續輝久、関口睦夫
- Organizer
  第18回日本ミトコンドリア学会年会
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] ミトコンドリア呼吸鎖複合体不全によるヒトiPS細胞由来がん細胞モデル2018
- Author(s)
  岡素雅子、林道夫、田口健一、續輝久、関口睦夫
- Organizer
  第41回日本分子生物学会ワークショップ企画［1PW2-14 ヒトiPS細胞を用いた発がん初期過程の解析］
- Invited
- Data Source
  KAKENHI-PROJECT-18K07250
[Presentation] Human proteins that recognize oxidative RNA damage2017
- Author(s)
  Hayakawa H., Ishii, T., Sekiguchi, M.
- Organizer
  Oxidative Stress & Disease, Gordon Research Conferences (Lucca, Italy)
- Place of Presentation
  Lucca, Italy
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07453
[Presentation] 酸化損傷を受けたRNA鎖に結合する新規因子の同定2017
- Author(s)
  石井健士、井川達弘、関口猛、早川浩、関口睦夫
- Organizer
  日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K07453
[Presentation] Human proteins that recognize oxidative RNA damage.2017
- Author(s)
  Hayakawa, H., Ishii, T., Sekiguchi, M.
- Organizer
  Gordon Research Conf. Oxidative Stress and Disease
- Place of Presentation
  Lucca, Italy
- Year and Date
  2017-03-19
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] 酸化損傷mRNAの代謝に関わる新規因子の探索2016
- Author(s)
  石井健士、早川浩、関口猛、関口睦夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-29
- Data Source
  KAKENHI-PROJECT-16K07453
[Presentation] Function of high-mobility group A proteins in DNA damage signaling for the induction of apoptosis triggered by O6-methylguanine.2016
- Author(s)
  Fujikane, R., Komori, K., Sekiguchi, M., Hidaka, M.
- Organizer
  The 10th 3R Symposium
- Place of Presentation
  Matsue, Japan
- Year and Date
  2016-11-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] アルキル化剤によって引き起こされるアポトーシスに関わる新規因子の同定と解析2016
- Author(s)
  藤兼亮輔、関口睦夫、日高真純
- Organizer
  第23回日本歯科医学会総会
- Place of Presentation
  福岡
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] 酸化損傷mRNAの代謝に関わる新規因子の探索2016
- Author(s)
  石井健士、早川浩、関口猛、関口睦夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] 毒性物質の排出における出芽酵母Gtr1タンパク質の働き2016
- Author(s)
  関口猛、石井健士、早川浩、古野伸明、小林英紀、関口睦夫
- Organizer
  第39回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2016-11-29
- Data Source
  KAKENHI-PROJECT-16K07453
[Presentation] 毒性物質の排出における出芽酵母Gtr1タンパク質の働き2016
- Author(s)
  関口猛、石井健士、早川浩、古野伸明、小林英紀、関口睦夫
- Organizer
  第39回日本分子生物学会年
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] A novel function of HMGA family proteins in the induction of apoptosis triggered by O6-methylguanine in DNA.2016
- Author(s)
  9.Fujikane, R., Takeishi, Y., Sekiguchi, M., Hidaka M.
- Organizer
  第75回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2016-10-06
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] ミスマッチ修復依存のアポトーシス誘導に関わるクロマチンリモデラーの機能2016
- Author(s)
  武石幸容、藤兼亮輔、高橋達郎、関口睦夫、日高真純
- Organizer
  第39回日本分子生物学会年
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] アポトーシス誘導過程に起こるクロマチン構造変化の解析.2016
- Author(s)
  武石幸容、藤兼亮輔、関口睦夫、日髙真純
- Organizer
  第23回日本歯科医学会総会
- Place of Presentation
  福岡
- Year and Date
  2016-10-21
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] ヒトNudixファミリータンパク質によるゲノム安定化維持機構の解析．2016
- Author(s)
  橋口一成、梅津桂子、関口睦夫
- Organizer
  第39回日本分子生物学会年
- Place of Presentation
  横浜
- Year and Date
  2016-11-30
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] 活性酸素による突然変異の生起とその抑制.2015
- Author(s)
  伊東理世子、橋口一成、関口睦夫.
- Organizer
  第 38回日本分子生物学会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] O6メチルグアニンによりひき起こされるミスマッチ修復依存のアポトーシス誘導に関わる新規因子の同定.2015
- Author(s)
  藤兼亮輔、関口睦夫、日高真純.
- Organizer
  第38回日本分子生物学会第 88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] 変異原性ヌクレオチドはどこへ行くのか？2015
- Author(s)
  関口睦夫、伊東理世子、関口猛、早川浩、井口八郎
- Organizer
  日本遺伝学会第87回大会
- Place of Presentation
  仙台
- Year and Date
  2015-09-24
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] ミスマッチ修復に依存したアポトーシス誘導に関わるクロマチン動態の解析.2015
- Author(s)
  武石幸容、藤兼亮輔、関口睦夫、日高真純
- Organizer
  第38回日本分子生物学会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] RagA/RRAG A結合タンパク質Nop132と相互作用するタンパク質の同定2015
- Author(s)
  関口猛
- Organizer
  第５回Tor 研究会
- Place of Presentation
  新潟
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] Molecular tactics to escape from the threat of oxidation RNA damage.2015
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  Tomas Lindahl Conference on DNA Reapir.
- Place of Presentation
  Oslo, Norway
- Year and Date
  2015-07-17
- Invited
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] 遺伝子破壊細胞株を用いたヒトNudix ファミリータンパク質の機能解析.2015
- Author(s)
  橋口一成、石井健士、早川浩、関口睦夫.
- Organizer
  第38回日本分子生物学会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-26340040
[Presentation] Translational errors caused by ROS2013
- Author(s)
  J.-P. Cai, D.-P. Dai, H. Hayakawa, M. Sekiguchi
- Organizer
  第86回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] 大腸菌における8-オキソグアニンを含むヌクレオチドの排除機構2013
- Author(s)
  伊東理世子、井口八郎、関口猛、関口睦夫
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  慶應義塾大学日吉キャンパス（横浜市港北区）
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] 大腸菌における8-オキソグアニンンを含むヌクレオチドの排除機構2013
- Author(s)
  伊東理世子、井口八郎、関口猛、関口睦夫
- Organizer
  日本遺伝学会
- Place of Presentation
  慶應義塾大学日吉キャンパス（横浜市港北区）
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Introduction to gene expression under oxidative stress2013
- Author(s)
  M. Sekiguchi
- Organizer
  第86回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] 酸素ストレス下の遺伝子発現機構2013
- Author(s)
  井口八郎、伊東理世子、関口猛、関口睦夫
- Organizer
  日本遺伝学会第85回大会
- Place of Presentation
  慶應義塾大学日吉キャンパス（横浜市港北区）
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Translational errors caused by ROS2013
- Author(s)
  J.-P. Cai, D.-P. Dai, H. Hayakawa, M. Sekiguchi
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Intorduction to gene expression under oxidative stress2013
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Introduction to gene expression under oxidative stress2013
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  第86会日本生化学会大会
- Place of Presentation
  パシフィコ横浜（横浜市西区）
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] 酸素ストレス下の遺伝子発現機構2013
- Author(s)
  井口八郎、伊東理世子、関口猛、関口睦夫
- Organizer
  日本遺伝学会第85回大会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] 大腸菌における8-オキソグアニンを含むヌクレオチドの排除機構2013
- Author(s)
  伊東理世子、井口八郎、関口猛、関口睦夫
- Organizer
  日本遺伝学会第85回大会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Molecular mechanisms of the induction of apoptosis to suppress mutation and cancer2012
- Author(s)
  M. Hidaka, S. Sano, R. Fujikane, T.H. Lim, R. Sakagami, Y. Nakatsu, T. Tsuzuki, M. Sekiguchi
- Organizer
  第35回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Molecular mechanism of the induction of apoptosis to suppress mutation and Cancer2012
- Author(s)
  Masumi Hidaka, Shiori Sano, Ryosuke Fujikane, Teik How Lim, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] HeLa細胞に導入したグアニンヌクレオチドの運命2012
- Author(s)
  関口猛、早川浩、関口睦夫
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  九州大学医学部
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] 酸化ストレスによるRNAの異常を防ぐ酵素系2012
- Author(s)
  伊東理世子、高木康光、瀬戸山大樹、早川浩、関口睦夫
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  九州大学医学部
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Molecular mechanisms for accurate gene expression under oxidative stress2012
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  US-Japan DNA Repair Meeting
- Place of Presentation
  National Conference Center, Virginia, USA
- Invited
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Molecular mechanisms for accurate gene expression under oxidative stress2012
- Author(s)
  M. Sekiguchi
- Organizer
  US-Japan DNA Repair Meeting
- Invited
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] HeLa細胞に導入したグアニンヌクレオチドの運命2012
- Author(s)
  関口猛、早川浩、関口睦夫
- Organizer
  日本遺伝学会第84回大会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] 酸化ストレスによるRNAの異常を防ぐ酵素系2012
- Author(s)
  伊東理世子、高木康光、瀬戸山大樹、早川浩、関口睦夫
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  九州大学医学部
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Molecular mechanism of the induction of apoptosis to suppress mutation and Cancer2012
- Author(s)
  Masumi Hidaka, Shiori Sano, Ryosuke Fujikane, Teik How Lim, Ryuji Sakagami, Yoshimichi Nakatsu, Teruhisa Tsuzuki, Mutsuo Sekiguchi
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡国際会議場
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] 酸化ストレスによるRNAの異常を防ぐ酵素系2012
- Author(s)
  伊東理世子、髙木康光、瀬戸山大樹、早川浩、関口睦夫
- Organizer
  日本遺伝学会第84回大会
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Molecular mechanisms for accurate gene expression under oxidative stress2012
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  US-Japan DNA Repair Meeting
- Place of Presentation
  National Conference Center, Virginia, USA
- Invited
- Data Source
  KAKENHI-PROJECT-24657006
[Presentation] Specific binding of human proteins to 8-oxoguanine-containing RNA2011
- Author(s)
  A.Fujikane, H.Hayakawa, R.Ito, K.Nakayama, M.Sekiguchi
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-16
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Cleavage of oxidized nucleotides for prevention of mutation2011
- Author(s)
  R.Ito, Y.Takagi, T.Arimori, Y.Yamagata, M.Sekiguchi, H.Hayakawa
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Characterization of human NUDT5 that hydrolyzes oxidized nucleotides2011
- Author(s)
  伊東理世子、関口睦夫、山縣ゆり子、中津可道、早川浩
- Organizer
  日本遺伝学会
- Place of Presentation
  京都大学
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] MTH1 prevents translational errors caused by oxidized guanine of RNA in mammalian cells2011
- Author(s)
  蔡剣平、戴大鵬、高木康光、早川浩、関口睦夫
- Organizer
  日本遺伝学会
- Place of Presentation
  京都大学
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Roles of MGMT and MLH1 in the development of resistance to methylating anti-cancer drugs2007
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  2nd Internat.Conf.on MGMT
- Place of Presentation
  Mainz,Germany
- Year and Date
  2007-06-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Presentation] Modes of actions of two types of antineoplastic drugs,dacarbazine and ACNU,to induce apoptosis2007
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  66th Annun.Meeting of Japanese Cancer Assoc
- Place of Presentation
  Yokohama,Japan
- Year and Date
  2007-10-03
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Presentation] Genetic stability under oxidative stress.2007
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  3rd Japan-US DNA Repair Meeting
- Place of Presentation
  Sendai, Japan.
- Year and Date
  2007-05-08
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Presentation] Genetic stability under oxidative stress2007
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  3rd Japan-US DNA Repair Meeting
- Place of Presentation
  Sendai,Japan
- Year and Date
  2007-05-08
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Presentation] Roles of MGMT and MLH1 in the development of resistance to methylating anti-cancer drugs.2007
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  2nd Internat. Conf. on MGMT
- Place of Presentation
  Mainz, Germany.
- Year and Date
  2007-06-15
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18370005
[Presentation] Roles of MutT, MTH1 and AUF1 in defence against oxidative stress
- Author(s)
  Mutsuo Sekiguchi
- Organizer
  US-Japan DNA Repair Meeting
- Place of Presentation
  グランドエキシブ鳴門（徳島市）
- Year and Date
  2014-10-28 – 2014-10-30
- Invited
- Data Source
  KAKENHI-PROJECT-22370003

1. ITO Riyoko (10140865)

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2. SANADA Masayuki (40084264)

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7. 豊島久真男 (90029760)

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SEKIGUCHI Mutsuo 関口 睦夫

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内在性酸化ストレス制御による発がん初期シグナル分子の同定Ongoing

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Novel mechanisms for eliminating oxidatively damaged RNAPrincipal Investigator

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Genetic system for functioning to prevent agingPrincipal Investigator

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Mechanisms for quality control of RNA in mammalian cellsPrincipal Investigator

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発がん抑制におけるDNA修復とアポトーシスの役割Principal Investigator

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発がん抑制におけるミスマッチ遺伝子の役割Principal Investigator

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Development of a detection and evaluation system for carcinogens with the use of cell lines deficient in DNA repair genesPrincipal Investigator

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発がん抑制におけるミスマッチ修復の役割Principal Investigator

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SEKIGUCHI Mutsuo 関口睦夫