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SUGINO Akio  杉野 明雄

ORCIDConnect your ORCID iD *help
Researcher Number 90231737
Affiliation (based on the past Project Information) *help 2006: 大阪大学, 大学院生命機能研究科, 教授
2006: 阪大, 教授
2003 – 2005: 大阪大学, 大学院・生命機能研究科, 教授
2003 – 2004: 大阪大学, 生命機能研究科, 教授
2002: 教授 … More
1992 – 2001: 大阪大学, 微生物病研究所, 教授
1993: 大阪大学, 微生物研究所, 教授
1992 – 1993: 大阪大学, 微研, 教授 Less
Review Section/Research Field
Principal Investigator
Molecular biology / Biological Sciences / Molecular biology
Except Principal Investigator
Cell biology / Molecular biology
Keywords
Principal Investigator
出芽酵母 / DNAポリメラーゼ / Cdc7 / 細胞周期 / DNAヘリカーゼ / クローニング / 染色体DNA複製 / DNAポリメラーゼε / Dbf4 protein kinase / 蛋白リン酸化酵素 … More / 分裂酵母 / 遺伝子発現 / Saccharomyces cerevisiae / In vitro DNA複製 / Cdc7-Dbf4複合体 / Eukaryotic chromosomal DNA replication / RF-C複合体 / Dbf4 protein kinase complex / Dbf4複合体 / 染色体複製開始 / CDC7-DBF4複合体 / チェックポイントコントロール / multicopy suppressor / ORC複合体 / 真核細胞染色体複製 / CDC / 一本鎖DNA結合蛋白 / DNAポリメラーゼα-プライマーゼ / ヒト染色体DNA複製開始 / CDC7遺伝子 / 突然変異株 / ガン化の機構 / ショウジョウバエ / 発生と分化 / PCR / 染色体DNA複製開始 / protein kinase / 出芽酵母S.cerevisiae / CDC7 / DBF4 / CDC7 homolog / Northern hybridization / Drosophila melanogaster / DNA polymerase II / 塩基配列 / DNA repair / DNA ポリメラーゼβ / DNA ポリメラーゼε / Yeast Saccharomyces cerevisiae / in vitro DNA repair / double strand break repair / DNA修復 / DNAポリメラーゼβ / YEL055C / 染色体複製 / アフリカツメガエル / 哺乳動物細胞 / チェックポイント / ほ乳動物細胞 / pre RC(複製開始前複合体) / Mcm蛋白 / Cdc / Db4f protein kinase / GINS / Polε複合体 / アフリカツメガエル卵粗抽出液 / セントロメア / 複製開始 / pre RC (複製開始名複合体) / 遺伝学 / 癌 / マウスES細胞 / ミューテーター / 真核細胞染色体DNA複製 / DNAボリメラーゼ / DNAポリメラーゼサブユニット / 細胞周期チェックポイントコントロール / Phosphatase / 細胞周期チェックポイント制御 / ORC蛋白 / 複製開始部位 / DNAポリメラーゼ補助因子 / 蛋白精製 / DNA polymerase II (epsilon) / DNA polymerase III (delta) / DNA polymerase subunits / three DNA polymerase model / Cdc 7-Dbf4 complex / phosphatase / DNA複製複合体 / 多量発現ベクター / バキューロウイルスベクター / 昆虫細胞 / Cdc7-Dbf4 protein kinase複合体 / DNAポリメラーゼ複合体 / バキュロウイルスベクター / YACベクター / RFC複合体 / DNA Replication protein complex / Expression vector / Baculovirus expression vector / Insect cells / Budding yeast / RF-C complex / DNA polymerase complex / 複製ライセンス因子 / Mcm蛋白群 / 複製開始因子 / ORC / Dbf-Cdc7複合体 / S.cerevisiae / S.pombe / Mcm2-7 proteins / Mcm10 / DNA polymeraseII (epsilon) / Dpb11 / Sld / 真核生物染色体複製機構 / Leading鎖複製装置 / Lagging鎖複製装置 / Mcm2-7蛋白複合体 / Dbf4プロテインキナーゼ / チェックポイント制御 / Bloom症候群原因遺伝子産物 / ヘリカーゼ / Mcm蛋白複合体 / 真核生物染色体DNA複製 / Leading鎖合成装置 / Lagging鎖合成装置 / PCNA / 細胞周期チェックポイント / Leading strand synthesis apparatus / Lagging strand synthesis apparatus / DNA helicase / Mcm2-7 complex / Checkpoint control / 染色体DNA複製開始機構 / Mcm2-7蛋白群 / Mcm10蛋白 / S-期チェックポイント / Rad53蛋白 / Xenopus egg in Vitro Replication system / MCM10蛋白 / Cdc7p / Dbf4p複合体 / in vitro 複製系 / Xenopus egg / Sー期チェックポイント / Chromosomal DNA replication / Mcm2-7 protein complex / Mcm10 protein / S-phase checkpoint / Rad53p / Protein kinase / Xenopus egg in vitro replication system … More
Except Principal Investigator
DNA複製 / 細胞周期 / サイクリン / がん遺伝子 / 複製蛋白 / 複製起点 / 染色体分配 / 細胞分裂 / ライセンス因子 / DNA修復 / ノックアウトマウス / ゲノム情報 / 癌遺伝子 / 癌抑制遺伝子 / ユビキチン / TGFβ / RV蛋白質 / ^<cdc2>キナーゼ / ゲノム複製 / 複製開始点 / ARS配列 / 複製遺伝子 / 複製酵素 / 組換え遺伝子 / 組換え蛋白 / ホリデー構造 / 核骨格 / 相同組換え / 非相同組換え / 組換えホットスポット / 減数分裂 / 遺伝子組換え / ホットスポット / RAD51 / RecA / がん抑制遺伝子 / DNAポリメラーゼalpha / cdc2キナーゼ / RB蛋白質 / TGFbeta / DNAトランスアクション / 遺伝情報維持 / 複製 / 修復 / 組換え / 転写 / 複製開始蛋白 / チェックポイント / 複製装置 / 複製開始の調節 / SeqA / DnaA / 複製開始 / 複製エラー / ミスマッチ修復 / 酵素ラジカル / フレームシフト / 繰り返し配列 / 酸素ラジカル / 突然変異 / DNA / DNA組換え / DNAポリメラーゼ / 遺伝子 / 自然突然変異 / 遺伝的不安定性 / がん / 遺伝病 / 転写調節 / シグナル分子 / 細胞内物質輸送 / アポトーシス / 転写調節因子 / レチノイン酸 / DNA損傷 / インポーティン / 細胞分化 / SOX / POU / コケイン症候群 / DNA polymerase / ターゲティング / importin / XAB / 先端生命科学 / アジア環太平洋地域 / 分子生物学ネットワーク(A-IMBN) / ゲノミックス / プロテオミックス / 国際共同研究 / プロテオーム / Frontier Life Sciences / Asia and Pacific Rim region / Asia-Pacific Molecular Biology Network / Genomics / Proteomics / International collabolation Less
  • Research Projects

    (25 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (68 People)
  •  DNAポリメラーゼεミューテーター変異マウスの構築とその発がん機構の解析Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  DNAポリメラーゼεミューテーター変異マウスの構築とその発がん機構の解析Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  真核生物染色体DNA複製フォークの分子ダイナミズムPrincipal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      2003 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Molecular biology
    • Research Institution
      Osaka University
  •  個体生命を支える素機構の統合

    • Principal Investigator
      近藤 寿人 (近藤 壽人)
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for COE Research
    • Research Institution
      Osaka University
  •  Development of frontier life science research for prevention and therapy of endemic diseases in Asia and the Pacific Rim Region

    • Principal Investigator
      KOIKE Katsuro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Special Purposes
    • Research Institution
      Japanese Foundation for Cancer Research
  •  DNA Replication Apparatus and S-Phase Checkpoint ControlPrincipal Investigator

    • Principal Investigator
      SUGINO Akio
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      Osaka University
  •  細胞複製装置:染色体の複製・分配機構

    • Principal Investigator
      平賀 壮太 (平賀 壯太 / 平賀 莊太)
    • Project Period (FY)
      1996 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kumamoto University
  •  突然変異の分子病態

    • Principal Investigator
      真木 寿治
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Nara Institute of Science and Technology
  •  Molecular Mechanism of Initiation of DNA ReplicationPrincipal Investigator

    • Principal Investigator
      SUGINO Akio
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Molecular biology
    • Research Institution
      Osaka University
  •  Molecular Mechanism of Chromosomal DNA Replication ApparatusPrincipal Investigator

    • Principal Investigator
      SUGINO Akio
    • Project Period (FY)
      1996 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Research Institute for Microbial Diseases, Osaka University
  •  真核生物DNA修復反応におけるDNAポリメラーゼβ及びεの役割Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  細胞複製装置:染色体の複製・分配機構

    • Principal Investigator
      平賀 壯太
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Molecular biology
    • Research Institution
      Kumamoto University
  •  EXPRESSION OF EUKARYOTIC DNA REPLICATION PROTEIN COMPLEXS AND THEIR SIMPLE PURIFICATION METHODPrincipal Investigator

    • Principal Investigator
      SUGINO Akio
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      Osaka University
  •  真核生物DNA修復反応におけるDNAポリメラーゼβ及びεの役割Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  DNAトランスアクションと遺伝情報の安定性

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Cell biology
    • Research Institution
      Osaka University
  •  組換え機構の分子的基礎

    • Principal Investigator
      堀田 康雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nagoya University
  •  細胞周期の制御機構における癌遺伝子、癌抑制遺伝子および関連遺伝子の研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  ヒト染色体DNA複製開始を制御している遺伝子の単離と解析Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  ショウジョウバエDNAポリメラーゼεの細胞内での役割Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  Molecular biological and genetical study on the mechanism of chromosomal DNA replicaiton in eukaryotes -Yeast as a model-Principal Investigator

    • Principal Investigator
      SUGINO Akio
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Molecular biology
    • Research Institution
      Osaka University
  •  真核細胞染色体複製開始の細胞周期による制御機構の研究Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Osaka University
  •  細胞周期の制御機構における癌遺伝子・癌抑制遺伝子および関連遺伝子の研究

    • Principal Investigator
      花岡 文雄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      The Institute of Physical and Chemical Research
  •  ヒト染色体DNA複製開始を制御している遺伝子の単離と解析Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Cancer Research
    • Research Institution
      Osaka University
  •  ゲノム複製開始の制御

    • Principal Investigator
      吉川 寛
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Nara Institute of Science and Technology
      Osaka University
  •  ショウジョウバエDNAポリメラーゼεの細胞内での役割Principal Investigator

    • Principal Investigator
      杉野 明雄
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University

All 2006 2004

All Journal Article

  • [Journal Article] Historical view of DNA replication studies, with special reference to Japan.2006

    • Author(s)
      Sugino, A.
    • Journal Title

      IUBMB Life 58

      Pages: 323-327

    • Data Source
      KAKENHI-PROJECT-15107003
  • [Journal Article] Distinct roles of DNA polymerases, delta and epsilon at the replication fork in Xenopus egg extracts.2004

    • Author(s)
      Fukui, T., Waga, S., Sugino, A., et al.
    • Journal Title

      Genes Cells 9

      Pages: 179-191

    • Data Source
      KAKENHI-PROJECT-12CE2007
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  • 56.  関 丘 (40271118)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 57.  和賀 祥 (60222402)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 58.  榎本 武美 (80107383)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 59.  ISHIMI Yukio
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 60.  MORRISON Ala
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 61.  DIFFLEY John
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 62.  CAMPBELL Jud
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 63.  TYE BikーKwoo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 64.  JOHN.F.X. Diffey
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 65.  LELAND H. Johnston
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 66.  BIK-KWOON Tye
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 67.  JUDITH L. Campbell
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 68.  TYE Bik Kwoo
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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