TAKAGI Yasumitsu 高木康光

… Alternative Names

高木康光タカギヤスミツ

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Researcher Number	20212003
Other IDs
Affiliation (based on the past Project Information) *help	2014: 福岡歯科大学, 歯学部, 准教授 2010 – 2012: 福岡歯科大学, 歯学部, 准教授 2005: Fukuoka Dental College, Frontier Research Center, Assistant professor, 学術フロンティア研究センター, 助教授 2004: 福岡歯科大学, フロンティア研究センター, 助教授 1999 – 2003: 福岡歯科大学, 歯学部, 助教授 1989: Keio Univ. School of Med. Instructor, 医学部・医化学, 助手
Review Section/Research Field	Principal Investigator Molecular biology / Genetics/Genome dynamics / Biological Sciences Except Principal Investigator Biological Sciences / 代謝生物化学 / Pathobiological dentistry/Dental radiology / 遺伝 / Molecular biology / Genetics/Genome dynamics
Keywords	Principal Investigator 自然発がん / 酸化グアニン / 自然突然変異 / DNA酸化損傷 / DNA修復 / Spontaneous carcinogenesis / oxidation of guanine nucleotides / Spontaneous mutation / DNA oxidation / DNA repair … More / 酸化ストレス / ヌクレオチド / ゲノム維持 / ゲノム構築 … More Except Principal Investigator 突然変異 / アポトーシス / DNA修復 / アルキル化剤 / mutation / 細胞株 / マウス / 発がん / 抗がん剤 / O^6-メチルグアニン / mouse / 活性酸素 / ミスマッチ修復 / 遺伝子欠損マウス / Fatty Acid / Thyroid Follicular Cell / Cytosolic Factor / NADPH oxidoreductase / Superoxide / Polymorphonuclear Leukocyte / O^-_2 / スーパーオキシドアニオン / 甲状腺細胞 / 多形核白血球 / 甲状腺濾胞細胞 / ス-パ-オキサイド / 脂肪酸 / 甲状腺瀘胞細胞 / 細胞質因子 / NADPH酸化酵素 / ス-パ-オキシド / 好中球 / alkylated agent / apoptosis / DNA Repair / 細胞死 / アポソーシス / anticancer agent / gene deficient / cell line / tumorigenesis / O^6-methylguanine / DNA repair enzyme / 発ガン / 遺伝子欠損 / DNA修復酵素 / E.coli / oxidized RNA / gene cloning / gene targeting / cancer / active oxygen / 活性酵素 / 大腸菌 / 酸化RNA / 遺伝子クローニング / 遺伝子ターゲティング / 蛋白質 / 癌 / タンパク質 / ストレス / 酵素 / ゲノム / がん / 核酸 / 遺伝子 / 8-オキソグアニン / RNA結合タンパク質 / 分解酵素 / 酸化ストレス / 発現異常 / 老化 / 前駆体ヌクレオチド / RNA / 培養細胞 / 遺伝子欠損細胞株 / 発がん物質 / 細胞増殖 / メチルトランスフェラーゼ / 胸腺腫 Less

Genetic system for functioning to prevent aging
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Fukuoka Dental College
酸化ストレス下で、正常な複製や転写を保証する酵素の役割Principal Investigator
- Principal Investigator
  
  高木康光
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genetics/Genome dynamics
- Research Institution
  Fukuoka Dental College
The mechanism of cell death inducedby O^6-methylguanine DNA : the role of MSH2 and MLH1 proteins
- Principal Investigator
  
  ITO Riyoko
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathobiological dentistry/Dental radiology
- Research Institution
  Fukuoka Dental College
内在性発がん要因としての酸化グアニンとその排除の機構Principal Investigator
- Principal Investigator
  
  高木康光
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka Dental College
A novel mechanism for preventing mutations caused by oxidation of guanine nucleotidesPrincipal Investigator
- Principal Investigator
  
  TAKAGI Yasumitsu
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
発がん抑制におけるDNA修復とアポトーシスの役割
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka Dental College
発がん抑制におけるミスマッチ遺伝子の役割
- Principal Investigator
  
  関口睦夫
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Fukuoka Dental College
Development of a detection and evaluation system for carcinogens with the use of cell lines deficient in DNA repair genes
- Principal Investigator
  
  ITOH Riyoko, 関口睦夫
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  遺伝
- Research Institution
  Fukuoka Dental College
発がん抑制におけるミスマッチ修復の役割
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Fukuoka Dental College
Regulatory mechanisms for mutagenesis and carcinogenesis
- Principal Investigator
  
  SEKIGUCHI Mutsuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Molecular biology
- Research Institution
  Fukuoka Dental College
Purification and Molecular Mechanisms of O^-_ generating System in Polymorphonuclear Leukocytes and Thyroid Cells
- Principal Investigator
  
  ISHIMURA Yuzuru
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  代謝生物化学
- Research Institution
  Keio University

All 2012 2011 2005 2004

All Journal Article Presentation

[Journal Article] Age-dependent increasers in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analized by LC-MS/MS: Urinary 8-oxoguanine as a novel biomaker of aging2012
- Author(s)
  Wei Gan, Ben Nie, Fei Shi, Xin-Min Xu, Jian-Chan Qian, Yasumitsu Takagi, Hiroshi Hayakawa, Mutsuo Sekiguchi, Jian-Ping Cai
- Journal Title
  
  Free Radical Biology and Medicine
  
  Volume: 52 Pages: 1700-1707
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Human MTH3(NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosplate: Comparison with MTH1 and MTH22012
- Author(s)
  Yasumitsu Takagi, Daiki Setoyama, Riyoko Ito, Hiroshi Ｈａｙａｋａｗａ, Hiroyuki kamiya, Yuriko Yamagata, Mutsuo Sekiguchi
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 287 Pages: 21541-21549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22370003
[Journal Article] Diverse Substrate Recognition and Hydrolysis Mechanisms of Human NUDT52011
- Author(s)
  Takao Arimori, at al
- Journal Title
  
  Nucleic Acids Res.
  
  Volume: 39 Issue: 20 Pages: 8972-8983
- DOI
  10.1093/nar/gkr575
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22131007, KAKENHI-PROJECT-22370003, KAKENHI-PROJECT-22570007, KAKENHI-PUBLICLY-23121523, KAKENHI-PROJECT-23790052
[Journal Article] PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells2005
- Author(s)
  Hidaka M, Takagi Y, Takano TY, Sekiguchi M.
- Journal Title
  
  Nucleic Acids Res. 33(17)
  
  Pages: 5703-5712
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] PCNA/MutSa-mediated binding of MutLα to replicative DNA with mismatched base to induce apoptosis in human cells.2005
- Author(s)
  Hidaka, M., Y.Takagi, Y.T.Takano, M.Sekiguchi
- Journal Title
  
  Nucleic Acid Research 33・17
  
  Pages: 5703-5712
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells : effects of Mgmt and Mlh1 mutations.2004
- Author(s)
  Sanada, M., Takagi, Y., Ito, R., Sekiguchi, M.
- Journal Title
  
  DNA Repair 3
  
  Pages: 413-120
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Journal Article] Killing and mutagenic actions of dacarbazine, a chemotherapeutic alkylating agent, on human and mouse cells : effects of Mgmt and Mlh1 mutations2004
- Author(s)
  Sanada M, Takagi Y, Ito R, Sekiguchi M.
- Journal Title
  
  DNA Repair 3
  
  Pages: 413-420
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16591902
[Presentation] 酸化ストレスによるRNAの異常を防ぐ酵素系2012
- Author(s)
  伊東理世子、高木康光、瀬戸山大樹、早川浩、関口睦夫
- Organizer
  日本遺伝学会第84回大会
- Place of Presentation
  九州大学医学部
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Cleavage of oxidized nucleotides for prevention of mutation2011
- Author(s)
  R.Ito, Y.Takagi, T.Arimori, Y.Yamagata, M.Sekiguchi, H.Hayakawa
- Organizer
  日本分子生物学会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2011-12-14
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] MTH1 prevents translational errors caused by oxidized guanine of RNA in mammalian cells2011
- Author(s)
  蔡剣平、戴大鵬、高木康光、早川浩、関口睦夫
- Organizer
  日本遺伝学会
- Place of Presentation
  京都大学
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-22370003
[Presentation] Cleavage of oxidized nucleotides for prevention of mutation2011
- Author(s)
  高木康光
- Organizer
  日本分子生物学会
- Place of Presentation
  横浜
- Year and Date
  2011-12-08
- Data Source
  KAKENHI-PROJECT-22570007

1. SEKIGUCHI Mutsuo (00037342)

# of Collaborated Projects: 8 results

# of Collaborated Products: 9 results
2. ITO Riyoko (10140865)

# of Collaborated Projects: 7 results

# of Collaborated Products: 5 results
3. SHIMOKAWA Hidetoshi (50122792)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. SANADA Masayuki (40084264)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. 瀬戸山大樹 (30550850)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
6. SAKUMI Kunihiko (50211933)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAYAKAWA Hiroshi (70150422)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ISHIMURA Yuzuru (40025599)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANAKA Torahiko (90171785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. MAKINO Ryu (40101026)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 荻島正 (70177153)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAGI Yasumitsu 高木 康光

高木 康光 タカギ ヤスミツ

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酸化ストレス下で、正常な複製や転写を保証する酵素の役割Principal Investigator

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内在性発がん要因としての酸化グアニンとその排除の機構Principal Investigator

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A novel mechanism for preventing mutations caused by oxidation of guanine nucleotidesPrincipal Investigator

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[Journal Article] Age-dependent increasers in the oxidative damage of DNA, RNA, and their metabolites in normal and senescence-accelerated mice analized by LC-MS/MS: Urinary 8-oxoguanine as a novel biomaker of aging2012

Author(s)

Journal Title

Data Source

[Journal Article] Human MTH3(NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosplate: Comparison with MTH1 and MTH22012

Author(s)

Journal Title

Data Source

[Journal Article] Diverse Substrate Recognition and Hydrolysis Mechanisms of Human NUDT52011

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DOI

Data Source

[Journal Article] PCNA-MutSalpha-mediated binding of MutLalpha to replicative DNA with mismatched bases to induce apoptosis in human cells2005

Author(s)

Journal Title

Description

Data Source

TAKAGI Yasumitsu 高木康光

高木康光タカギヤスミツ