Horiuchi Motohiro 堀内基広

… Alternative Names

HORIUCHI Motohiro 堀内基広

堀内基弘ホリウチモトヒロ

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Researcher Number	30219216
Other IDs
External Links
Affiliation (Current)	2025: 北海道大学, 獣医学研究院, 教授
Affiliation (based on the past Project Information) *help	2017 – 2025: 北海道大学, 獣医学研究院, 教授 2016 – 2017: 北海道大学, 獣医学研究科, 教授 2011 – 2015: 北海道大学, (連合)獣医学研究科, 教授 2003 – 2012: 北海道大学, 大学院・獣医学研究科, 教授 2006: Hokkaido University, Graduate School of Veterinary Medicine., Professor, 大学院獣医学研究科, 教授 … More 2004 – 2006: 北海道大学, 獣医学研究科, 教授 2003: 北海道大学, 大学院, 教授 2000 – 2002: 帯広畜産大学, 原虫病研究センター, 助教授 1995 – 1996: 帯広畜産大学, 原虫病分子免疫研究センター, 助教授 1990 – 1994: Obihiro Univ. Vet. Med., Instructor., 畜産学部, 助手 Less
Review Section/Research Field	Principal Investigator Applied veterinary science / Basic Section 42020:Veterinary medical science-related / Basic veterinary science/Basic zootechnical science / Veterinary medical science / Medium-sized Section 42:Veterinary medical science, animal science, and related fields / Applied veterinary science / Basic veterinary science/Basic zootechnical science / Biological Sciences Except Principal Investigator Applied veterinary science / Applied veterinary science … More / 基礎獣医学 / Basic veterinary science/Basic zootechnical science / Polymer chemistry / Living organism molecular science / Virology Less
Keywords	Principal Investigator プリオン / BSE / プリオン病 / アストロサイト / スクレイピー / PrP / ミクログリア / scrapie / prion / 神経変性疾患 … More / 自然免疫 / 伝達性海綿状脳症 / 脳神経疾患 / 感染症 / 獣医学 / AFT3 / 神経細胞 / siRNA / ALY / PCR / モンゴル / 網羅的遺伝子発現解析 / 次世代シークエンサー / ケモカイン / 走化性 / 再生医療 / 骨髄由来間葉系幹細胞 / 神経変性 / DNAマイクロアレイ / 神経細胞死 / ブルセラ / カンピロバクター / 薬剤耐性菌 / 食品媒介感染症 / 難治性神経変性疾患 / CRISPR/Cas9 / アデノ随伴ウイルスベクター / 小胞体ストレス / ストレス応答 / フェロトーシス / ATF3 / 治療効果 / 間葉系幹細胞 / RNA-sequencing / 神経科学 / ERストレス / 小胞体ストレス応答 / RNA-seq / DNA Microarray / Neuro2a / Opti-MEM / Follicular dendritic cell / Gut-associated lymphoid tissue / バイエル氏板 / ALYマウス / 消化管付髄リンパ装置 / 濾胞樹状細胞 / 消化管付随リンパ装置 / Genotype / Mongolia / モンゴル羊 / プリオン蛋白遺伝子型 / 疫学調査 / モンゴル産羊 / 羊プリオン蛋白遺伝子 / 遺伝子型 / サイトカイン / IL-17 / IL-10 / CXCL10 / CCL2 / CD14 / IL10 / 磁気細胞分離法 / 抗炎症性サイトカイン / 神経栄養因子 / β-ガラクトシダーゼ / DNA マイクロアレイ / モノクロナール抗体 / 合成ペプチド / PrPSc / 構造転換 / スクレイピ- / 分子進化 / CPV / MEV / FPLV / 猫パルボウイルス亜群 … More Except Principal Investigator プリオン / BSE / スクレイピー / スクレイピ- / 伝達性海綿状脳症 / prion / Scrapie / 構造生物学 / 部位特異的スピンラベル法 / グリコサミノグリカン / AHSP / PrP / ELISA / 遺伝子 / 牛 / cDNA / PrP gene / 培養細胞 / PrP遺伝子 / 人獣共通感染症 / 電子スピン共鳴(ESR) / 糖鎖 / 糖鎖モジュール化法 / 硫酸化糖 / アルツハイマー / 糖鎖ライブラリー / 抗体 / Biopsy / Pre-clinica diagnosis / Detection of PrP / Unconventional agent / Scrapie agent / SAF蛋白 / 発症前 / 診断法 / 非通常病原体 / 発症前の診断 / PrP検出 / バイオプシ-診断 / Ileum / Mouse / Transport / Nerve / Immunology / Prion / 回腸遠位部 / 体内伝播 / 病態 / 神経 / マウス / 免疫 / Structural biology / 3D structure / electron spin resonance (ESR) / nitroxide spin probe / site-directed spin labeling (SDSL) / bovine spongiformencephalopathy (BSE) / Creutzfeldt-Jacob disease (CJD), / 銅イオン / 分子間距離 / 双極子相互作用 / スピンラベル / 電子スピン共鳴 / ニトロオキシドスピンプロ一ブ / タンパク質高次構造 / ニトロオキシドスピンプローブ / 牛海綿状脳症(BSE) / クロイツヘルトヤコブ病(CJD) / food poisoning / Johne's disease / Rickettsia / leptospirosis / type E hepatitis / infectious disease / deer / wildlife / ウイルス性肝炎 / 狩猟 / 野生動物管理 / 家畜衛生 / ウィルス性肝炎 / ニホンジカ / 食中毒 / ヨーネ / リケッチア / レプトスピラ / E型肝炎 / 感染症 / シカ / 野生動物 / heparan sulfate / glycomics / oligosaccharide / sulfated sugars / module synthesis / glycosaminoglycans / モジュール化 / 光反応性プローブ / ライブラリー合成 / 糖鎖医薬 / モジュール合成 / グライコミクス / ヘパラン硫酸 / cattle / zoonosis / transcription regulation / cytokine / hematopoietic precursor cells / molecular diagnosis / prion diseases / PrPc(cellular prion protein) / 転写制御 / サイトカイン / 造血前駆細胞 / 分子診断 / プリオン病 / synthetic peptide / glycosaminoglycan / conformational transformation / scrapie / 種特異性 / 合成ペプチド / 構造転換 / CD spectrum / proteinase K resistance / recombinant PrP^c / in vitro structural conversion / prion amvloid / in vitr o assay / PrPC / コンゴーレッド結合 / CDスペクトル / コンゴ-レッド結合 / 試験管内構造変化 / 組換プリオン蛋白 / Preclinical diagnosis / Transmissible spongiform encephalopathies / ウエスタンブロット / 早期診断 / ELISA法 / 早期診断法 / cultured cells / Replication of scrapie agent / Expression of PrP gene / Genotype on PrP / ウシPrP遺伝子 / 変異PrP遺伝子 / 病原体複製 / 導入遺伝子発現細胞 / 羊PrP遺伝子型 / RFLP TYPES / PrP^<Sc> / SURVEY / SCRAPIE / サ-ベイランス / PrP遺伝子型 / 海綿状脳症 / RFPL型 / PrPsc / サーベイランス / Nucleotide sequence / Gene rearrangement / Receptor / T cell / Lymphocyte / Bovine / 再構成 / 塩基配列 / 遺伝子再構成 / レセプタ- / T細胞 / リンパ球 / ウシ / spongiform encephaloparthy / Gene expression / Cell culture / 分子クロ-ニング / 遺伝子発現 / インフルエンザ / インフルエンサ / 距離情報 / ニトロオキシドプローブ / ESR分光法 / CJD / パルスESR / 動的構造変化 / スピンラベル法 / AFM / 人畜共通感染症 / 異常プリオン / フラーレン / 糖蛍光試薬 / 糖鎖プローブ / エピトープ / 抗原賦活化法 / 免疫組織化学 / 培養神経細胞 / 神経変異 / プリオン蛋白 Less

プリオン感染に脆弱な神経細胞種の同定と誘導される神経細胞死の分子機構の解析Principal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
One health approach for surveillance of foodborne and antimicrobial resistant bacterial in MongoliaPrincipal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  2024 – 2027
- Research Category
  
  Fund for the Promotion of Joint International Research (International Collaborative Research)
- Review Section
  
  Medium-sized Section 42:Veterinary medical science, animal science, and related fields
- Research Institution
  Hokkaido University
Studies on the control of disease progression of prion diseases by transition of glial cell polarizationPrincipal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Role of stress-induced transcription factor ATF3 on neurodegeneration of prion diseasesPrincipal Investigator
- Principal Investigator
  
  HORIUCHI MOTOHIRO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 42020:Veterinary medical science-related
- Research Institution
  Hokkaido University
Identification of MSC subpopulations that have therapeutic potential for neurodegenerative disordersPrincipal Investigator
- Principal Investigator
  
  HORIUCHI MOTOHIRO
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
Elucidation of the mechanism for neurodegeneration in prion diseases through neuron-glia cross-talkPrincipal Investigator
- Principal Investigator
  
  HOROUICHI MOTOHIRO
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Veterinary medical science
- Research Institution
  Hokkaido University
Role of functional change of microglia in neuropathogenesis of prion diseasesPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Motohiro
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Identification of factors that involved in migration of mesenchymal stem cells to lesions of neurodegenerative diseasesPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Motohiro
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Hokkaido University
Structural analysis of zoonosis-related high-molecular protein aggregation by double electron-electron resonance (DEER) technique
- Principal Investigator
  
  INANAMI Osamu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
再生医療を応用したプリオン病治療モデルの確立Principal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Molecular imaging of prion protein by atomic force microscop yand a novel electro-spin-resonance techniques
- Principal Investigator
  
  I NANAML Osamu
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Elucidation of the mechanism on the formation of early pathological lesion of prion diseasesPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Motohiro
- Project Period (FY)
  2006 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Structural analysis of prion proteins and mechanism of PrPsc transition by using a novel dynamic molecular structure analysis
- Principal Investigator
  
  INANAMI Osamu
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
STUDY ON THE NERVE-IMMUNE SYSTEMS AND CELLULAR FACTORS INFLUENCE TO THE PATHOGENICTTY AND DISTRIBUTION OF PRP^<Sc>IN ANIMAL PRION DISEASES
- Principal Investigator
  
  ISHIGURO Naotaka
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Gifu University
硫酸化糖を分子基盤とする抗BSE試薬の開発と異常プリオン抑制機構の解析
- Principal Investigator
  
  NISHIDA Yoshihiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Living organism molecular science
- Research Institution
  Nagoya University
Molecular pathology for down-regulation of erythroid-specific genes in prion diseases
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  Hokkaido University
Module Assembly and Evaluation of Artificial Glycosaminoglycans
- Principal Investigator
  
  NISHIDA Yoshihiro
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Polymer chemistry
- Research Institution
  Chiba University
  Nagoya University
Is the wild deer population considered to be the source of infectious diseases for other animals and human being?
- Principal Investigator
  
  SUZUKI Masatsugu
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Gifu University
  Hokkaido University
Molecluar mechanism of propagation of abnormal prion protein in the cellsPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Motohiro
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  HOKKAIDO UNIVERSITY
非通常病原体プリオンの分子機構
- Principal Investigator
  
  片峰茂
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Nagasaki University
免疫組織化学的手法によるプリオン蛋白の迅速検出法並びに検出感度に関する研究
- Principal Investigator
  
  FURUOKA Hidefumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied veterinary science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
プリオンの増殖を規定する正常型-異常型プリオン蛋白質の分子間相互作用に関する研究Principal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Basic studies on the biosynthesis of pathogenic prion protein
- Principal Investigator
  
  MAKINO Sou-ichi, 品川森一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Etiological and molecular genetic surveillance of scrapie in MongoliaPrincipal Investigator
- Principal Investigator
  
  HORIUCHI Motohiro, 品川森一
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Studies on the entry ports for the scrapie agent (prion)Principal Investigator
- Principal Investigator
  
  HORIUCHI Motohiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
In Vitro studies on the formation of prion amyloid
- Principal Investigator
  
  SHINAGAWA Morikazu
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
伝達性海綿状脳症関連蛋白質PrPによる神経細胞死の分子機構に関する研究Principal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Development of sensitive diagnostic methods for transmissible spongiform encephalopathies.
- Principal Investigator
  
  SHINAGAWA Morikazu
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  Obihiro University of Agricutture and Veterinary Medicine
猫パルボウイルス亜群の分子進化と犬パルボウイルス出現機構に関する研究Principal Investigator
- Principal Investigator
  
  堀内基広
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Basic veterinary science/Basic zootechnical science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Study on the role of a host protein, PrP,in scrapie.
- Principal Investigator
  
  SHINAGAWA Morikazu
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  Obihiro University of agriculture and Veterinary Medicine
Survey on scrapie in Japanese : detection of PrP^<Sc> and studies on the distribution of the PrP genotypes in sheep.
- Principal Investigator
  
  SHINAGAWA Morikazu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Applied veterinary science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Role of Host-coded Protein "PrP"in Scrapie : Preparation of Transformed Cells with Heterologous or Artificially Mutated PrP Gene.
- Principal Investigator
  
  SHINAGAWA Morikazu
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  基礎獣医学
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Isolation and molecular characterization of bovine T-cell receptor genes
- Principal Investigator
  
  ISHIGURO Naotaka
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  基礎獣医学
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine
Development of Diagnostic Method for Unconventional Agent (Scrapie Gagent) Infection.
- Principal Investigator
  
  SHINAGAWA Morikazu
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Applied veterinary science
- Research Institution
  Obihiro University of Agriculture and Veterinary Medicine

[Book] 人獣共通感染症改訂3版　「牛海綿状脳症、変異クロイツフェルト・ヤコブ病」の項（pp184-189）を分担執筆2015
- Author(s)
  堀内　基広
- Total Pages
  447
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-15H02475
[Book] プリオンの感染と細胞内動態2013
- Author(s)
  山崎剛士、堀内基広
- Publisher
  Dementia Japan
- Data Source
  KAKENHI-PROJECT-23658233
[Book] プリオン病最新医学2011
- Author(s)
  堀内基広
- Data Source
  KAKENHI-PROJECT-23658233
[Book] 獣医微生物学(第3版)「プリオンとプリオン病」2011
- Author(s)
  堀内基広
- Total Pages
  6
- Publisher
  文永堂出版
- Data Source
  KAKENHI-PROJECT-23248050
[Book] 最新医学「プリオン」2011
- Author(s)
  堀内基広
- Total Pages
  8
- Publisher
  最新医学社
- Data Source
  KAKENHI-PROJECT-23248050
[Book] 「スクレイピー」人と動物のプリオン病(山内一也, 立石潤監修)2003
- Author(s)
  品川森一, 堀内基広
- Total Pages
  47
- Publisher
  近代出版
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Discovery of Biologically Optimized Polymyxin Derivatives Facilitated by Peptide Scanning and In Situ Screening Chemistry2023
- Author(s)
  Kaguchi R, Katsuyama A, Sato T, Takahashi S, Horiuchi M, Yokota SI, Ichikawa S
- Journal Title
  
  J Am Chem Soc
  
  Volume: 145 Issue: 6 Pages: 3665-3681
- DOI
  10.1021/jacs.2c12971
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19416, KAKENHI-PROJECT-22K15241, KAKENHI-PROJECT-21H03622, KAKENHI-PROJECT-23K23772, KAKENHI-PROJECT-23K24001, KAKENHI-PROJECT-23K18171
[Journal Article] Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan2023
- Author(s)
  Nagano Yutaro、Kuronuma Koji、Kitamura Yasuo、Nagano Kanami、Yabe Hayato、Kudo Sayaka、Sato Toyotaka、Nirasawa Shinya、Nakae Mami、Horiuchi Motohiro、Yokota Shin-ichi、Fujiya Yoshihiro、Saito Atsushi、Takahashi Satoshi、Chiba Hirofumi
- Journal Title
  
  Infection Control & Hospital Epidemiology
  
  Volume: 44 Issue: 11 Pages: 1809-1815
- DOI
  10.1017/ice.2023.68
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K19416, KAKENHI-PROJECT-23K07656, KAKENHI-PROJECT-20K08570, KAKENHI-PROJECT-21H03622, KAKENHI-PROJECT-23K23772
[Journal Article] High prevalence of colistin heteroresistance in specific species and lineages of Enterobacter cloacae complex derived from human clinical specimens2023
- Author(s)
  Fukuzawa Shota、Sato Toyotaka、Aoki Kotaro、Yamamoto Soh、Ogasawara Noriko、Nakajima Chie、Suzuki Yasuhiko、Horiuchi Motohiro、Takahashi Satoshi、Yokota Shin-ichi
- Journal Title
  
  Annals of Clinical Microbiology and Antimicrobials
  
  Volume: 22 Issue: 1 Pages: 60-60
- DOI
  10.1186/s12941-023-00610-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19416, KAKENHI-PROJECT-21H03622, KAKENHI-PROJECT-23K23772
[Journal Article] Extended application of the rapid post‐mortem test kit for bovine spongiform encephalopathy to chronic wasting disease2022
- Author(s)
  Matsuura Yuichi、Miyazawa Kohtaro、Horiuchi Motohiro、Suzuki Akio、Yokoyama Mayumi、Imamura Morikazu、Ikeda Keigo、Iwamaru Yoshifumi
- Journal Title
  
  Microbiology and Immunology
  
  Volume: - Issue: 5 Pages: 212-215
- DOI
  10.1111/1348-0421.12968
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03119, KAKENHI-PROJECT-20K06403, KAKENHI-PROJECT-23K23772
[Journal Article] Colistin Susceptibility in Companion Animal-Derived Escherichia coli, Klebsiella spp., and Enterobacter spp. in Japan: Frequent Isolation of Colistin-Resistant Enterobacter cloacae Complex2022
- Author(s)
  Sato T, Harada K, Usui M, Yokota SI, Horiuchi M
- Journal Title
  
  Front Cell Infect Microbiol
  
  Volume: 12 Pages: 946841-946841
- DOI
  10.3389/fcimb.2022.946841
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19416, KAKENHI-PROJECT-21H03622, KAKENHI-PROJECT-23K23772
[Journal Article] Monitoring of chronic wasting disease using real-time quaking-induced conversion assay in Japan2021
- Author(s)
  SUZUKI Akio、SAWADA Kazuhei、ERDENEBAT Temuulen、YAMASAKI Takeshi、TOBIUME Minoru、SUGA Kinuyo、HORIUCHI Motohiro
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 83 Issue: 11 Pages: 1735-1739
- DOI
  10.1292/jvms.21-0368
- NAID
  130008116910
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Refeeding activates neurons in the dorsomedial hypothalamus to inhibit food intake and promote positive valence2021
- Author(s)
  Daigo Imoto, Izumi Yamamoto, Hirokazu Matsunaga, Toya Yonekura, Ming-Liang Lee, Kan X Kato, Takeshi Yamasaki, Shucheng Xu, Taiga Ishimoto, Satoshi Yamagata, Ken-Ichi Otsuguro, Motohiro Horiuchi , Norifumi Iijima, Kazuhiro Kimura, Chitoku Toda
- Journal Title
  
  Molecular Metabiolism
  
  Volume: 54 Pages: 101366-101366
- DOI
  10.1016/j.molmet.2021.101366
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02857, KAKENHI-PROJECT-19H03119, KAKENHI-PROJECT-21K18275, KAKENHI-PROJECT-23K21265
[Journal Article] Research Note: Antimicrobial resistance of Campylobacter species isolated from chickens near Ulaanbaatar city, Mongolia2021
- Author(s)
  Byambajav Zolzaya、Bulgan Erdenebat、Hirai Yuji、Nakayama Momoko、Tanaka Misaki、Nitta Yurika、Suzuki Akio、Umemura Takashi、Altankhuu Bold、Tsagaan Alimaa、Vanaabaatar Batbaatar、Janchivdorj Erdenebaatar、Purevdorj Nyam-Osor、Ayushjav Narantuya、Yamasaki Takeshi、Horiuchi Motohiro
- Journal Title
  
  Poultry Science
  
  Volume: 100 Issue: 3 Pages: 100916-100916
- DOI
  10.1016/j.psj.2020.11.079
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Relationship between lactational performance and metabolic parameters of Mongolian native grazing mares2021
- Author(s)
  SANDAGDORJ Badrakh、BAIGALMAA Tserenpil、BURENJARGAL Sedhuu、HORIUCHI Motohiro、ENKHDALAI Munkhbat、BAYANBAT Davaakhuu、JANCHIV Dashdorj、JAMYANDORJ Ooyo、ULZII-ORSHIKH Purevdorj、NYAM-OSOR Purevdorj
- Journal Title
  
  Journal of Equine Science
  
  Volume: 32 Issue: 3 Pages: 91-98
- DOI
  10.1294/jes.32.91
- NAID
  130008086318
- ISSN
  1340-3516, 1347-7501
- Language
  English
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Isolation of Human Lineage, Fluoroquinolone-Resistant and Extended-β-Lactamase-Producing Escherichia coli Isolates from Companion Animals in Japan2021
- Author(s)
  Sato Toyotaka、Yokota Shin-ichi、Tachibana Tooru、Tamai Satoshi、Maetani Shigeki、Tamura Yutaka、Horiuchi Motohiro
- Journal Title
  
  Antibiotics
  
  Volume: 10 Issue: 12 Pages: 1463-1463
- DOI
  10.3390/antibiotics10121463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03119, KAKENHI-PROJECT-21H03622
[Journal Article] Selective neuronal vulnerability is involved in cerebellar lesions of Guinea pigs infected with bovine spongiform encephalopathy (BSE) prions: Immunohistochemical and electron microscopic investigations2020
- Author(s)
  Sakaguchi S, Shintani S, Kamio K, Sekiya A, Kato S, Muroi Y, Horiuchi M, Furuoka H.
- Journal Title
  
  Neuropathology
  
  Volume: 40 Issue: 2 Pages: 167-179
- DOI
  10.1111/neup.12613
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Involvement of N- and C-terminal region of recombinant cervid prion protein in its reactivity to CWD and atypical BSE prions in real-time quaking-induced conversion reaction in the presence of high concentrations of tissue homogenates2020
- Author(s)
  Suzuki Akio、Sawada Kazuhei、Yamasaki Takeshi、Denkers Nathaniel D、Mathiason Candace K、Hoover Edward A、Horiuchi Motohiro
- Journal Title
  
  Prion
  
  Volume: 14 Issue: 1 Pages: 283-295
- DOI
  10.1080/19336896.2020.1858694
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Enhanced phosphorylation of PERK in primary cultured neurons as an autonomous neuronal response to prion infection2020
- Author(s)
  Tanaka Misaki、Yamasaki Takeshi、Hasebe Rie、Suzuki Akio、Horiuchi Motohiro
- Journal Title
  
  PLOS ONE
  
  Volume: 15 Issue: 6 Pages: e0234147-e0234147
- DOI
  10.1371/journal.pone.0234147
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Tracking and clarifying differential traits of the classical- and atypical L-type bovine spongiform encephalopathy prions after transmission from cattle to cynomolgus monkeys2019
- Author(s)
  Hagiwara, K., Yuko Sato, Y., Yamakawa, Y., Hara, H., Tobiume, M., Okemoto-Nakamura, Y., Sata, T., Horiuchi, M., Shibata, H., Ono, F.
- Journal Title
  
  PLoS One
  
  Volume: 14
- NAID
  120006812014
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] The first isolation and identification of canine parvovirus (CPV) type 2c variants during 2016 - 2018 genetic surveillance of dogs in Mongolia.2019
- Author(s)
  Uyangaa Temuujin, Ariunaa Tserendorj, Jumpei Fujiki, Yoshihiro Sakoda, Erdene-Ochir Tseren-Ochir, Masatoshi Okamatsu, Keita Matsuno, Tumenjargal Sharav, Motohiro Horiuchi, Takashi Umemura, Tungalag Chultemdorj.
- Journal Title
  
  Infect. Genet. Evol.
  
  Volume: 73 Pages: 936-942
- DOI
  10.1016/j.meegid.2019.05.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Journal Article] Estimation of prion infectivity in tissues of cattle infected with atypical BSE by real time-quaking induced conversion assay2019
- Author(s)
  Sawada K, Suzuki A, Yamasaki T, Iwamaru Y, Matsuura Y, Miyazawa K, Masujin K, Atarashi R, Horiuchi M
- Journal Title
  
  Journal of Veterinary Medical Science
  
  Volume: 81 Issue: 6 Pages: 846-850
- DOI
  10.1292/jvms.19-0003
- NAID
  130007660450
- ISSN
  0916-7250, 1347-7439
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02475, KAKENHI-PROJECT-19H03119
[Journal Article] Enhancement of binding avidity by divalent binding is a key mechanism for abnormal isoform of prion protein-specific detection by anti-PrP monoclonal antibody 1322019
- Author(s)
  Suzuki A, Yamasaki T, Hasebe R, Horiuchi M
- Journal Title
  
  PLoS One
  
  Volume: 14 Issue: 6 Pages: e0217944-e0217944
- DOI
  10.1371/journal.pone.0217944
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03119, KAKENHI-PROJECT-17K08070
[Journal Article] Flow cytometric detection of PrPSc in neurons and glial cells from prion-infected mouse brains2018
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M.
- Journal Title
  
  Journal of Virology
  
  Volume: 92 Issue: 1
- DOI
  10.1128/jvi.01457-17
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08070, KAKENHI-PROJECT-17K14954, KAKENHI-PROJECT-15H02475, KAKENHI-PROJECT-16K15033
[Journal Article] Retrograde transport by clathrin-coated vesicles is involved in intracellular transport of PrPSc in persistently prion-infected cells2018
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M.
- Journal Title
  
  Scientific Reports
  
  Volume: 8 Issue: 1 Pages: 12241-12241
- DOI
  10.1038/s41598-018-30775-1
- NAID
  120006539249
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08070, KAKENHI-PROJECT-15H02475, KAKENHI-PROJECT-17K14954
[Journal Article] Therapeutic effect of autologous compact bone-derived mesenchymal stem cell transplantation on prion disease2017
- Author(s)
  Shan Z, Hirai Y, Nakayama M, Hayashi R, Yamasaki T, Hasebe R, Song CH, Horiuchi, M
- Journal Title
  
  J Gen Virol
  
  Volume: 98 Pages: 2615-2627
- NAID
  120006523738
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Journal Article] Therapeutic effect of autologous compact bone-derived mesenchymal stem cell transplantation on prion disease2017
- Author(s)
  Shan Z, Hirai Y, Nakayama M, Hayashi R, Yamasaki T, Hasebe R, Song CH, Horiuchi M
- Journal Title
  
  Journal of General Virology
  
  Volume: 98 Issue: 10 Pages: 2615-2627
- DOI
  10.1099/jgv.0.000907
- NAID
  120006523738
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08070, KAKENHI-PROJECT-15H02475
[Journal Article] Establishment of a simple cell-based ELISA for the direct detection of abnormal isoform of prion protein from prion-infected cells without cell lysis and proteinase K treatment2016
- Author(s)
  Shan Z, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Journal Title
  
  Prion
  
  Volume: 10 Issue: 4 Pages: 305-318
- DOI
  10.1080/19336896.2016.1189053
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02475, KAKENHI-PROJECT-26450397, KAKENHI-PROJECT-16K15033
[Journal Article] Comparison of abnormal isoform of prion protein in prion-infected cell lines and primary-cultured neurons by PrPSc-specific immunostaining2016
- Author(s)
  Tanaka M, Fujiwara A, Suzuki A, Yamasaki T, Hasebe R, Masujin K, Horiuchi M
- Journal Title
  
  J Gen Virol
  
  Volume: 97 Issue: 8 Pages: 030-2042
- DOI
  10.1099/jgv.0.000514
- NAID
  120006331855
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475, KAKENHI-PROJECT-26450397, KAKENHI-PROJECT-16K15033
[Journal Article] PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains2016
- Author(s)
  Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, and Caughey B
- Journal Title
  
  J. Virol.
  
  Volume: 90 Pages: 4905-4913
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Journal Article] Complement factors alter the amount of PrP(Sc) in primary-cultured mouse cortical neurons associated with increased membrane permeability2016
- Author(s)
  Hasebe R, Tanaka M, Suzuki A, Yamasaki T, Horiuchi M
- Journal Title
  
  Virology
  
  Volume: 496 Pages: 9-20
- DOI
  10.1016/j.virol.2016.05.014
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02475, KAKENHI-PROJECT-26450397, KAKENHI-PROJECT-16K15033
[Journal Article] PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains2016
- Author(s)
  Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, Caughey B
- Journal Title
  
  J Virol
  
  Volume: 90 Pages: 4905-4913
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Journal Article] PrPSc-Specific Antibody Reveals C-terminal Conformational Differences between Prion Strains2016
- Author(s)
  Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, Caughey B
- Journal Title
  
  J Virol
  
  Volume: 90 Issue: 10 Pages: 4905-4913
- DOI
  10.1128/jvi.00088-16
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Journal Article] Temporary upregulation of anti-inflammatory cytokine IL-13 expression in the brains of CD14 deficient mice in the early stage of prion infection.2014
- Author(s)
  Hasebe R, Suzuki A, Yamasaki T, Horiuchi M
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 454 Issue: 1 Pages: 125-130
- DOI
  10.1016/j.bbrc.2014.10.043
- NAID
  120005540293
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-26450397
[Journal Article] Characterization of intracellular dynamics of inoculated PrP-res and newly generated PrP(Sc) during early stage prion infection in Neuro2a cells.2014
- Author(s)
  Yamasaki T, Baron GS, Suzuki A, Hasebe R, Horiuchi M.
- Journal Title
  
  Virology
  
  Volume: 451-451 Pages: 324-325
- DOI
  10.1016/j.virol.2013.11.007
- NAID
  120005425355
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23780303
[Journal Article] Genetic diversity in the prion protein gene (PRNP) of domestic cattle and water buffaloes in Vietnam, Indonesia and Thailand.2014
- Author(s)
  Uchida L, Heriyanto A, Thongchai C, Hanh TT, Horiuchi M, Ishihara K, Tamura Y, Muramatsu Y
- Journal Title
  
  J Vet Med Sci
  
  Volume: 76 Pages: 1001-1008
- NAID
  130003391317
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23248050
[Journal Article] Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells.2014
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 9 Pages: e106516-e106516
- DOI
  10.1371/journal.pone.0106516
- NAID
  120005476205
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-26450397
[Journal Article] Absence of CD14 delays progression of prion diseases accompanied by increased microglial activation.2013
- Author(s)
  Sakai K, Hasebe R, Takahashi Y, Song CH, Suzuki A, Yamasaki T, Horiuchi M.
- Journal Title
  
  Journal of Virology
  
  Volume: 87 Issue: 24 Pages: 13433-13445
- DOI
  10.1128/jvi.02072-13
- NAID
  120005455879
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23248050
[Journal Article] プリオンの感染と細胞内動態2013
- Author(s)
  山﨑　剛士、堀内　基広
- Journal Title
  
  Dementia Japan
  
  Volume: 27 Pages: 215-224
- Data Source
  KAKENHI-PROJECT-23248050
[Journal Article] Therapeutic effect of peripheral administration of an anti-prion protein antibody on mice infected with prions2013
- Author(s)
  Ohsawa, N., Song, C.-H., Suzuki, A., Furuoka, H., Hasebe, R., and Horiuchi,M
- Journal Title
  
  Microbiol. Immunol
  
  Volume: 57(4) Pages: 288-297
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658233
[Journal Article] Therapeutic effect of peripheral administration of an anti-prion protein antibody on mice infected with prions.2013
- Author(s)
  Ohsawa N, Song CH, Suzuki A, Furuoka H, Hasebe R, Horiuchi M
- Journal Title
  
  Microbiology and Immunology
  
  Volume: 57 Issue: 4 Pages: 288-297
- DOI
  10.1111/1348-0421.12037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23780303
[Journal Article] Characterization of intracellular localization of PrPSc in prion-infected cells using monoclonal antibody that recognizes the region consisting of amino acids 119-127 of mouse2012
- Author(s)
  Yamasaki, T., Suzuki, A., Shimizu, T., Watarai, M., Hasebe, R. and Horiuchi, M
- Journal Title
  
  PrP. J. Gen. Virol
  
  Volume: 93(Pt3) Pages: 668-680
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658233
[Journal Article] Reaction of complement factors varies with prion strains in vitro and in vivo2012
- Author(s)
  Hasebe, R., Raymond, G. J., Horiuchi, M., and Caughey, B
- Journal Title
  
  Virology
  
  Volume: 423(2) Pages: 205-213
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658233
[Journal Article] Reaction of complement factors varies with prion strains in vitro and in vivo2012
- Author(s)
  Hasebe, R.
- Journal Title
  
  Virology
  
  Volume: 423 Issue: 2 Pages: 205-213
- DOI
  10.1016/j.virol.2011.11.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23658233, KAKENHI-PROJECT-23780303
[Journal Article] Characterization of intracellular localization of PrP^<Sc> in prioninfected cells using monoclonal antibody that recognizes the region consisting of amino acids 119-127 of mouse PrP2012
- Author(s)
  Yamasaki T., Suzuki A., Shimizu T., Watarai M., Hasebe R., Horiuchi M.
- Journal Title
  
  Journal of General Virology
  
  Volume: vol.93 no.3 Issue: 3 Pages: 668-680
- DOI
  10.1099/vir.0.037101-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J04181, KAKENHI-PROJECT-21590478, KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23658233, KAKENHI-PROJECT-23780303
[Journal Article] Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prion2011
- Author(s)
  Song, C.H., et al
- Journal Title
  
  J.Virol.
  
  Volume: 85 Issue: 21 Pages: 11069-11078
- DOI
  10.1128/jvi.05318-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390388, KAKENHI-PROJECT-23248050, KAKENHI-PROJECT-23658233
[Journal Article] Identification of chemoattractive factors involved in the migration of bone marrow-derived mesenchymal stem cells to brain lesions caused by prions2011
- Author(s)
  Song C.-H., Honmou, O., Furuoka, H. and Horiuchi, M
- Journal Title
  
  J. Virol
  
  Volume: 85(21) Pages: 11069-11078
- NAID
  120004027230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23658233
[Journal Article] Celldensity dependent increase of the amount of protease-resistant PrP in prion-infected Neuro2a mouse neuroblastoma cells.2010
- Author(s)
  Nakamitsu, S., Kurokawa, A., Yamasaki, T., Uryu, M., Hasebe, R., Horiuchi, M.
- Journal Title
  
  J. Gen. Virol. 91
  
  Pages: 563-569
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2010
- Author(s)
  Watanabe, Y., Hiraoka, W., Igarashi, M., Ito, K., Shimoyama, Y., Horiuchi, M., Yamamori, T., Yasui, H., Kuwabara, M., Inagaki, F., and Inanami, O.
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 394 Pages: 522-528
- NAID
  120002148672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380185
[Journal Article] Confomational Analysis of Soluble Oligomers of GFP Tagged Prion Protein by Fluorescence Fluctuation Spectroscopy2010
- Author(s)
  Sakata, H., Horiuchi, M., Takahashi, I., Kinjo, M.
- Journal Title
  
  Curr. Pharm. Biotechnol. 11
  
  Pages: 87-95
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2010
- Author(s)
  Watanabe, Y., Hiraoka, W., Igarashi, M., Ito, K., Shimoyama, Y., Horiuchi, M., Yamamori, T., Yasui, H., Kuwabara, M., Inagaki, F., Inanami, O.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 394(3)
  
  Pages: 522-528
- NAID
  120002148672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] Generation of monoclonal antibody that distinguishes PrPSc from PrPC and neutralizes prion infectivity.2009
- Author(s)
  Horiuchi, M., Karino, A., Furuoka, H., Ishiguro, N., Kimura, K., Shinagawa, M.
- Journal Title
  
  Virology 394
  
  Pages: 200-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] The effect of transplantation of immortalized human bone marrow-derived mesenchymal stem cells on mice infected with prion.2009
- Author(s)
  Song, C.-H., Honmou, O., Nakamura, K., Hamada, H., Furuoka, H., Hasebe, R., Horiuchi, M.
- Journal Title
  
  J. Virol. 83
  
  Pages: 5918-5927
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] The region approximately between amino acids 81 and 137 of proteinase K-resistant PrPSc is critical for the infectivity of the Chandler prion strain.2009
- Author(s)
  Shindoh, R., Kim, C.-L., Song, C.-H., Hasebe, R., Horiuchi, M.
- Journal Title
  
  J. Virol. 83
  
  Pages: 3852-3860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] A novel copper(II) coordination at His186 in full-length murine prion protein.2009
- Author(s)
  Watanabe Y, Hiraoka W, Igarashi M, Ito K, Shimoyama Y, Horiuchi M, Yamamori T, Yasui H, Kuwabara M, Inagaki F, Inanami O.
- Journal Title
  
  Biochem Biophys Res Commun. 394
  
  Pages: 522-528
- NAID
  120002148672
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21380185
[Journal Article] The region approximately between amino acids 81 and 137 of proteinase K-resistant PrP^<Sc> is critical for the infectivity of the Chandler prion strain2009
- Author(s)
  Shindoh, R., Kim, C.-L., Song, C.-H., Hasebe, R., and Horiuchi, M (CA)
- Journal Title
  
  J. Virol. 83
  
  Pages: 3852-3860
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] The effect of transplantation of immortalized human bone marrow-derived mesenchymal stem cells on mice infected with prion2009
- Author(s)
  Song, C.-H., Honmou, O., Nakamura, K., Hamada, H., Furuoka, H., Hasebe, R., and Horiuchi, M(CA: corresponding author)
- Journal Title
  
  J. Virol. (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] Generation of monoclonal antibody that distinguishes PrP^<Sc> from PrP^<C> and neutralizes prion infectivity.2009
- Author(s)
  Horiuchi, M., et al.,
- Journal Title
  
  Virology 394
  
  Pages: 200-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] Generation of monoclonal antibody that distinguishes PrP^<Sc> from PrP^C and neutralizes prion infectivity.2009
- Author(s)
  Horiuchi, M., et al.
- Journal Title
  
  Virology 394
  
  Pages: 200-207
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20658070
[Journal Article] Effect of intraventricular infusion of antiprion protein monoclonal antibodies on disease progression in prion-infected mice.2008
- Author(s)
  Song, C.-H., Furuoka, H., Kim, C.-L., Ogino, M., Suzuki, A., Hasebe, R., Horiuchi, M.
- Journal Title
  
  J. Gen. Virol. 89
  
  Pages: 1533-1544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] プリオンの増殖とその抑制2008
- Author(s)
  堀内基広
- Journal Title
  
  ウイルス感染症セミナー 10
  
  Pages: 13-25
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] Effect of intraventricular infusion of anti-prion protein monoclonal antibodies on disease progression in prion-infected mice2008
- Author(s)
  Song, C.-H., Furuoka, H., Kim, C.-L., Ogino, M., Suzuki, A., Hasebe, R., and Horiuchi, M (CA)
- Journal Title
  
  J. Gen. Virol. 89
  
  Pages: 1533-1544
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] プリオンの増殖とその抑制2008
- Author(s)
  堀内基広
- Journal Title
  
  ウイルス感染症セミナー 10
  
  Pages: 13-25
- Data Source
  KAKENHI-PROJECT-20658070
[Journal Article] Instability of familial spongiform encephalopathy-related prion mutants2008
- Author(s)
  Watanabe Y, Hiraoka.W, Shimoyama Y,Horiuchi M, Kuwabara M. and Inanami O.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 366
  
  Pages: 244-249
- NAID
  120000951795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380172
[Journal Article] Instability of familial spongiform encephalopathy-related prionmutants2008
- Author(s)
  Watanabe, Y., Hiraoica, W., Shimoyama, Y., Horiuchi, M., Kuwabara. M. and Inanami. O.
- Journal Title
  
  Biochem. Biophys. Res. Commun. 366
  
  Pages: 244-249
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19380172
[Journal Article] 牛海綿状脳症2007
- Author(s)
  中満智史、堀内基広
- Journal Title
  
  臨床とウイルス 35
  
  Pages: 301-310
- NAID
  10019820332
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] ヒト以外のプリオン病-特にウシ海綿状脳症について-2007
- Author(s)
  堀内基広、中満智史
- Journal Title
  
  日本臨床 65
  
  Pages: 1515-1520
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] プリオン2007
- Author(s)
  堀内基広
- Journal Title
  
  臨床とウイルス 35
  
  Pages: 293-300
- NAID
  10019820305
- Data Source
  KAKENHI-PROJECT-18208026
[Journal Article] Inhibition of PrPSc formation by synthetic 0-sufated glycopyranosides and their polymers.2006
- Author(s)
  Yamaguchi, S., Nishida, Y., Sasaki, K., Kambara, M., Kim, C.-L., Ishiguro, N., Nagatsuka, T., Uzawa, H., Horiuchi, M.
- Journal Title
  
  Biochemical and Biophysical Research Communications 349
  
  Pages: 485-491
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208030
[Journal Article] Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique.2006
- Author(s)
  Watanabe Y, nanami O, Horiuchi M, Hiraoka W, Shimoyama d., Fuyuhiko Y, Inagaki F, Kuwabara M
- Journal Title
  
  Biochemical and Biophysical Research Communications. 350(3)
  
  Pages: 549-556
- Data Source
  KAKENHI-PROJECT-17380178
[Journal Article] Alymphoplasia mice are resistant to prion infection via oral route.2006
- Author(s)
  Horiuchi, M. et al.
- Journal Title
  
  Jpn. J. Vet Med. 53
  
  Pages: 150-159
- NAID
  120000953470
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Sequence variation of bovine prion protein gene in Japanese cattle (Holstein and Japanese Black)2006
- Author(s)
  Satoshi, Nakamitsu, Takayuki, Miyazawa, Motohiro, Horiuchi, Sadao, Onoe, Yasunori, Ohoba, Hitoshi, Kitagawa, Naotaka, Ishiguro
- Journal Title
  
  The Journal of Veterinary Medical Science 68(1)
  
  Pages: 27-33
- NAID
  130000448081
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380180
[Journal Article] Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique.2006
- Author(s)
  Watanabe, Y., Watanabe, Y., Inanami, 0., Horiuchi, M., Hiraoka, W., Shimoyama, Y., Inagaki, F., Kuwabara, M.
- Journal Title
  
  Biochemical and Biophysical Research Communications 350
  
  Pages: 549-556
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16208030
[Journal Article] Inhibition of PrP^<Sc> formation by synthetic O-sulfated glycopyranosides and their polymers2006
- Author(s)
  S.Yamaguchi, Y.Nishida, M.Kambara, C.-L.Kim, N.Ishiguro, T.Nagatsuka, H.Uzawa, M.Horiuchi
- Journal Title
  
  Biochem. Biophys. Res. Commun. 349
  
  Pages: 485-491
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16350063
[Journal Article] Alymphoplasia mice are resistant to prion infection via oral route.2006
- Author(s)
  Horiuchi, M.et al.
- Journal Title
  
  Jpn.J.Vet Med. 53
  
  Pages: 150-159
- NAID
  120000953470
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Alymphoplasia mice are resistant to prion infection via oral route.2006
- Author(s)
  Horiuchi, M. et al.
- Journal Title
  
  Jpn.J.Vet Med. 53
  
  Pages: 150-159
- NAID
  120000953470
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Identification of pH-sensitive regions in the mouse prion by the cysteine-scanning spin-labeling ESR technique.2006
- Author(s)
  Watanabe Y, nanami O, Horiuchi M, Hiraoka W, Shimoyama d, Fuyuhiko Y, Inagaki F, Kuwabara M
- Journal Title
  
  Biochemical and Biophysical Research Communications 350(3)
  
  Pages: 549-556
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380178
[Journal Article] 異常型プリオン蛋白質の生合成と伝達(Biosynthesis and transmission of abnormal prion protein)2005
- Author(s)
  堀内基広
- Journal Title
  
  膜(membrane) 30
  
  Pages: 78-83
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Prion diseases as infectous disease transmissible from animals to humas.2005
- Author(s)
  Horiuchi, M.
- Journal Title
  
  Jpn.J.Clin.Med. 63
  
  Pages: 2213-2220
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Biosynthesis and transmission of abnormal prion protein.2005
- Author(s)
  Horiuchi, M.
- Journal Title
  
  Membrane 30
  
  Pages: 78-83
- NAID
  10015578051
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Prion diseases as zoonisis.2005
- Author(s)
  Horiuchi, M.
- Journal Title
  
  Virus 55
  
  Pages: 45-55
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Polymorphisms of caprine PrP gene detected in Japan2005
- Author(s)
  Yasuhisa, Kurosaki, Naotaka, Ishiguro, Motohiro, Horiuchi, Morikazu, Shinagawa
- Journal Title
  
  The Journal of Veterinary Medical Science 67(3)
  
  Pages: 321-323
- NAID
  110003963726
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380180
[Journal Article] BSE診断法の開発と現状2005
- Author(s)
  堀内基広
- Journal Title
  
  Virus Report 2
  
  Pages: 20-27
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Conformational change in full-length mouse prion : asite-directed spin-labeling study.2005
- Author(s)
  Inanami O, Hashida S, Iizuka D, Horiuchi M, Hiraoka W, Shimoyama Y, Nakamura H, Inagaki F, Kuwabara M.
- Journal Title
  
  Biochem.Biophys.Res.Commun. 335(3)
  
  Pages: 785-792
- Data Source
  KAKENHI-PROJECT-17380178
[Journal Article] BSE診断法の開発と現状(Development of BSE diagnosis methods and its current situation)2005
- Author(s)
  堀内基広
- Journal Title
  
  Virus Report 2
  
  Pages: 20-27
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] 異常型プリオン蛋白質の生合成と伝達2005
- Author(s)
  堀内基広
- Journal Title
  
  膜 30
  
  Pages: 78-83
- NAID
  10015578051
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] 人獣共通感染症としてのプリオン病2005
- Author(s)
  堀内基広
- Journal Title
  
  ウイルス 55
  
  Pages: 45-55
- NAID
  10016449383
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Surveillance of chronic wasting disease in Sika deer, Cervus Nippon, from Tokachi district in Hokkaido2005
- Author(s)
  Natsumi, Kataoka, Masakazu, Nishimura, Motohiro, Horiuchi, Naotaka, Ishiguro
- Journal Title
  
  The Journal of Veterinary Medical Science 67(3)
  
  Pages: 349-351
- NAID
  110003963733
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380180
[Journal Article] 動物由来感染症としてのプリオン病2005
- Author(s)
  堀内基広
- Journal Title
  
  日本臨床 63
  
  Pages: 2213-2220
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Conformational change in full-length mouse prion : a site-directed spin-labeling study.2005
- Author(s)
  Inanami O, Hashida S, Iizuka D, Horiuchi M, Hiraoka W, Shimoyama Y, Nakamura H, Inagaki F, Kuwabara M
- Journal Title
  
  Biochemical and Biophysical Research Communications 335(3)
  
  Pages: 785-792
- NAID
  120000967187
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17380178
[Journal Article] Development of BSE diagnosis methods and its current situation.2005
- Author(s)
  Horiuchi, M.
- Journal Title
  
  Virus Report 2
  
  Pages: 20-27
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Inhibition of prion propagation by anti-PrP antibody and possible application for therapeutics.2003
- Author(s)
  Horiuchi, M.
- Journal Title
  
  The Medical Frontline 58
  
  Pages: 2802-2808
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Recent topic on bovine spongiform encephalopathy.2003
- Author(s)
  Horiuchi, M.
- Journal Title
  
  Jpn.J.Geriat.Psychi. 14
  
  Pages: 1488-1494
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] 抗PrP抗体によるプリオン増殖抑制とプリオン病治療の可能性2003
- Author(s)
  堀内基広
- Journal Title
  
  最新医学 58
  
  Pages: 2802-2808
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] 牛海綿状脳症問題に関する最近の動向2003
- Author(s)
  堀内基広
- Journal Title
  
  老年精神医学雑誌 14
  
  Pages: 1488-1494
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Journal Article] Inhibition of PrP^<Sc> formation by synthetic O-sulfated glycopyranosides and their polymers
- Author(s)
  Satoko, Yamaguchi, Yoshihiro, Nishida, Kenji, Sasaki, Mikie, Kambara, Chan-Lan, Kim, Naotaka, Ishiguro, Takehiro, Nagatsuka, Hirotaka, Uzawa, Motohiro, Horiuchi
- Journal Title
  
  Biochemical and Biophysical Research Communications 349
  
  Pages: 485-491
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380180
[Journal Article] Frequencies of PrP genotypes in meat breeds of Japnese sheep and trail of selective breeding in experimental sheep flock
- Author(s)
  Jiro, Ohara, Tetsuro, Togari, Aya, Kurokawa, Junko, Maeda, Naotaka, Ishiguro, Hidefumi, Furuoka, Motohiro, Horiuchi
- Journal Title
  
  The Journal of Veterinary Medical Science 69(12)
  
  Pages: 1325-1329
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380180
[Patent] ヒトプリオン病を処置するための組成物2006
- Inventor(s)
  堀内基広、本望修、地子徳幸
- Industrial Property Rights Holder
  国立大学法人北海道大学、北海道、NCメディカルリサーチ株式会社
- Industrial Property Number
  2006-082037
- Filing Date
  2006-03-24
- Data Source
  KAKENHI-PROJECT-18208026
[Patent] ヒトプリオン病を処置するための組成物2006
- Inventor(s)
  堀内基広他
- Industrial Property Rights Holder
  国立大学法人北海道大学他
- Industrial Property Number
  2006-082037
- Filing Date
  2006-03-24
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15208029
[Presentation] Difference in cellular localization of PrPSc in primary neurons and astrocytes.2023
- Author(s)
  Suzuki A, Uwamori N, Erdenebat T, Tanaka M, Komatsu Y, Hoshika T, Sato T, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Brain region-dependent distinct neuronal cell deaths in prion-infected mice.2023
- Author(s)
  Hoshika T, Komatsu Y, Erdenebat T, Suzuki A, Sato T, Horiuchi M.
- Organizer
  Prion2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Excitatory neurotropism of prion 22L strain.2023
- Author(s)
  Erdenebat T, Suzuki A, Komatsu Y, Hoshika T, Sato T, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] プリオン感染マウスの中枢神経組織で観察される領域特異的な神経細胞死2023
- Author(s)
  星加恭、小松勇介、Erdenebat Temuulen、鈴木章夫、佐藤豊孝、堀内基広
- Organizer
  第70回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Analysis of mechanism for brain-region specific prion propagation in mice infected with prions2023
- Author(s)
  Erdenebat T, Suzuki A, Komatsu Y, Hoshika T, Sato T, Horiuchi M.
- Organizer
  Prion2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] マウス脳組織に存在するReal-time quaking-induced conversion法に対する阻害因子の同定とその除去法の応用2023
- Author(s)
  鈴木章夫、澤田和平、中島拓、小松勇介、佐藤豊孝、堀内基広
- Organizer
  第70回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Mechanism of neuronal cell death in prion-infected mice2022
- Author(s)
  HORIUCHI Motohiro, HOSHIKA Takashi, TEMUULEN Erdenebat, TANAKA Misaki, SUZUKI Akio, KOMATSU Yusuke, SATO Toyotaka
- Organizer
  Asian Pacific Prion Symposium (APPS) 2022
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Brain region-dependent distinct neuronal cell deaths in prion-infected mice2022
- Author(s)
  HOSHIKA Takashi, KOMATSU Yusuke, TEMUULEN Erdenebat, SUZUKI Akio, SATO Toyotaka, HORIUCHI Motohiro
- Organizer
  Asian Pacific Prion Symposium (APPS) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Involvement of ferroptosis in neurodegeneration in the thalamus of mice infected with prions2022
- Author(s)
  HOSHIKA Takashi, KOMATSU Yusuke, SUZUKI Akio, SATO Toyotaka, HORIUCHI Motohiro
- Organizer
  Sapporo Summer Symposium for One Health
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Fine characterization of localization of PrPSc in prion-infected primary neuronal cells2022
- Author(s)
  UWAMORI Nozomi, SUZUKI Akio, TANAKA Misaki, KOMATSU Yusuke , HORIUCHI Motohiro
- Organizer
  Asian Pacific Prion Symposium (APPS) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] プリオン病の神経変性における“Regulated Cell Death”の関与に関する研究2022
- Author(s)
  星加　恭、小松　勇介、鈴木　章夫、佐藤　豊隆、堀内　基広
- Organizer
  第165回日本獣医学会
- Data Source
  KAKENHI-PROJECT-23K23772
[Presentation] Monitoring of chronic wasting disease using real-time quaking conversion assay in Japan2021
- Author(s)
  Suzuki A, Sawada K, Erdenebat T, Yamasaki T, Tobiume M, Suga, K Horiuchi M
- Organizer
  14th Asian Society of Conservation Medicine
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] GABA-negative neuron-prone propagation of prion 22L strain2021
- Author(s)
  Erndenebat T, Uwamori N, Tanaka M, Komatsu Y, Suzuki A, Yamasaki T, Horiuchi M.
- Organizer
  Asian Pacific Prion Symposium 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] プリオン感染動物で見られるシナプス脱落についての比較病理学的検討2021
- Author(s)
  星加　恭、能瀬　絵菜、小松　勇介、堀内　基広、古岡　秀文
- Organizer
  第164回日本獣医学会
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] プリオン22L株のグルタミン酸作動性神経細胞における易増殖性2021
- Author(s)
  上森　望未、田中　美咲、Temuulen ERDENEBAT, 小松　勇介、鈴木　章夫、堀内　基広
- Organizer
  第164回日本獣医学会
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] プリオン感染初代培養神経細胞における神経細胞自律的変化の解析2020
- Author(s)
  田中　美咲、山﨑　剛士、長谷部　理絵、鈴木　章夫、堀内　基広
- Organizer
  第163回日本獣医学会
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] 高濃度脳組織乳剤存在下でのreal-time quaking-induced conversion反応における全長組換えシカプリオンタンパク質固有の反応性2020
- Author(s)
  鈴木章夫，澤田和平，山﨑剛士，堀内基広
- Organizer
  第163回日本獣医学会
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] Direct effects of generating PrPSc and consequences in neuron-enriched primary cultures2019
- Author(s)
  Tanaka M, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] Analysis of the unique reactivity of rCerPrP in real-time quaking-induced conversion reaction2019
- Author(s)
  Suzuki A, Sawada K, Yamasaki T, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] Characterization of gene expression profiles in brains of mice infected with typical and atypical BSEs2019
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Matsuura Y, Miyazawa K, Iwamaru Y, Horiuchi M
- Organizer
  Prion2019
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] PrPSc-specific staining and transcriptome analyses, towards understanding mechanisms of prion propagation and neurodegeneration2019
- Author(s)
  Horiuchi M, Suzuki A, Yamasaki T
- Organizer
  Asian Pacific Prion Symposium 2019
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H03119
[Presentation] Direct effects of PrPSc on synaptopathy and transcriptional alterations in cultured neurons2018
- Author(s)
  Tanaka M, Yamasak T, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Alteration of microglial activation state by mesenchymal stem cells2018
- Author(s)
  Nakayama M, Shan Z, Yamasaki T, Hasebe R, Sawada K, Horiuchi M
- Organizer
  Prion2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] 神経細胞特異的遺伝子発現解析によるプリオン病の神経変性機構の解析2018
- Author(s)
  島倉綾乃、山崎剛士、鈴木章夫、長谷部理絵、堀内基広
- Organizer
  第161回日本獣医学会
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] The estimation of infectivity titers in tissues of cattle infected with atypical BSE by RT-QuIC2018
- Author(s)
  Sawada K, Suzuki A, Yamasak T, Hasebe R, Iwamaru Y, Matsuura Y, Miyazawa K, Atarashi R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Identification and transcriptome analysis of brain regions vulnerable to neuronal loss in prion infection2018
- Author(s)
  Shimakura A, Yamasak T, Hasebe R, Horiuchi M
- Organizer
  Prion2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] 定型BSEおよび非定型BSEプリオンに感染したマウスの脳のトランスクリプトーム解析2018
- Author(s)
  山崎剛士、岩丸祥史、鈴木章夫、長谷部理絵、堀内基広
- Organizer
  第161回日本獣医学会
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Attempt to establish ex vivo co-culture system for analyses of the mechanism for neurodegeneration in prion diseases2018
- Author(s)
  Takamine H, Tanaka M, Yamasak T, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Comparison of intracerebral spread of abnormal isoform of prion protein between three rodent prion strains2018
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, and Horiuchi M
- Organizer
  第66回日本ウイルス学会
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] 緻密骨由来間葉系幹細胞によるミクログリアの活性化状態の調節2018
- Author(s)
  中山ももこ、Shan Zhifu、澤田　和平、山﨑剛士、長谷部理絵、堀内基広
- Organizer
  第161回日本獣医学会
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Unique reactivity of cervid recombinant PrP for the detection of L-BSE and CWD by RT-QuIC2017
- Author(s)
  Suzuki A, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Prion2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Unique reactivity of cervid recombinant PrP for the detection of L-BSE and CWD by RT-QuIC2017
- Author(s)
  Suzuki A, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Prion2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Activation state of glial cells in prion diseases2017
- Author(s)
  Kuroda M, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Joint Symposium between Seoul National University-Hokkaido Univerisyt “Infection and Immunity”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Activation state of glial cells in prion diseases2017
- Author(s)
  Kuroda M, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Therapeutic effect of autologous compact bone-derived mesenchymal stem cell transplantation on prion disease2017
- Author(s)
  Shan Z, Hirai Y, Hayashi R, Yamasaki T, Hasebe R, Song CH, Horiuchi M
- Organizer
  Prion2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Characterization of gene expression profiles in brains of mice infected with typical and atypical BSEs2017
- Author(s)
  Yamasaki T, Iwamaru Y, Matsuura Y, Kuroda M, Hasebe R, Okada H, Horiuchi M
- Organizer
  Asia Pacific Prion Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Therapeutic effect of autologous compact bone-derived mesenchymal stem cell transplantation on prion disease2017
- Author(s)
  Shan Z, Hirai Y, Hayashi R, Yamasaki T, Hasebe R, Song CH, Horiuchi M
- Organizer
  Prion2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Analyses of neuron-autonomous mechanisms for neurodegeneration in prion diseases on neuron-enriched primary cell cultures2017
- Author(s)
  Tanaka M, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Asia Pacific Prion Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Activation state of glial cells in prion diseases2017
- Author(s)
  Kuroda M, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Asia Pacific Prion Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Analyses of neuron-autonomous mechanisms for neurodegeneration in prion diseases on neuron-enriched primary cell cultures2017
- Author(s)
  Tanaka M, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Characterization of gene expression profiles in brains of mice infected with typical and atypical BSEs2017
- Author(s)
  Yamasaki T, Iwamaru Y, Matsuura Y, Kuroda M, Hasebe R, Okada H, and Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Activation state of glial cells in prion diseases2017
- Author(s)
  Kuroda M, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Joint Symposium between Seoul National University-Hokkaido University “Infection and Immunity”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Utility of cervid recombinant PrP for the detection of L-BSE and CDW prions by RT-QuIC2016
- Author(s)
  Suzuki A, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  第64回日本ウイルス学会
- Place of Presentation
  札幌コンベンションセンター、札幌
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Neuron and glial cell type-specific detection of PrPSc in prion-infected mouse brain by flow cytometry2016
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Prion2016
- Place of Presentation
  Hitotsubasi-kaikan, Tokyo, JAPAN
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Neuron and glial cell type-specific detection of PrPSc in prion-infected mouse brain by flow cytometry2016
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Prion2016
- Place of Presentation
  Hitotsubashi-kaikan, Tokyo, Japan
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Activation state of glial cells in prion diseases2016
- Author(s)
  Horiuchi M
- Organizer
  Prion2016
- Place of Presentation
  Hitotsubasi-kaikan, Tokyo, JAPAN
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Comparison of abnormal isoform of prion protein (PrPSc) in prion-infected cell lines and primary cultured neurons by PrPSc-specific immunostaining2016
- Author(s)
  Tanaka M, Fujiwara A, Suzuki A, Yamasaki T, Hasebe R, Masujin K, Horiuchi M
- Organizer
  Prion2016
- Place of Presentation
  Hitotsubashi-kaikan, Tokyo, Japan
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Activation state of glial cells in prion diseases2016
- Author(s)
  Horiuchi M
- Organizer
  Prion2016
- Place of Presentation
  Hitotsubashi-kaikan, Tokyo, Japan
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Comparison of abnormal isoform of prion protein (PrPSc) in prion-infected cell lines and primary cultured neurons by PrPSc-specific immunostaining2016
- Author(s)
  Tanaka M, Fujiwara A, Suzuki A, Yamasaki T, Hasebe R, Masujin K, Horiuchi M
- Organizer
  Prion2016
- Place of Presentation
  Hitotsubasi-kaikan, Tokyo, JAPAN
- Year and Date
  2016-05-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Utility of cervid recombinant PrP for the detection of L-BSE and CDW prions by RT-QuIC2016
- Author(s)
  Suzuki A, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  第64回日本ウイルス学会
- Place of Presentation
  札幌コンベンションセンター、札幌
- Data Source
  KAKENHI-PROJECT-16K15033
[Presentation] Highthrouput detection of PrPSc from prion-infected cells without PK treatment: Cell-based ELISA for novel screening method for anti-prion compounds2015
- Author(s)
  Shan Z, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Prion2015
- Place of Presentation
  Colorado State University, Fort Collins, Colorado, USA
- Year and Date
  2015-05-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Analysis of activation state of astrocytes with the progression of prion diseases2015
- Author(s)
  Kuroda M, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M.
- Organizer
  Prion2015
- Place of Presentation
  Colorado State University, Fort Collins, Colorado, USA
- Year and Date
  2015-05-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Immuno- and cell therapy as possible treatment for prion diseases2015
- Author(s)
  Horiuchi M
- Organizer
  Therapeutic approaches to prion disease and other neurodegenerative conditions associated with protein misfolding
- Place of Presentation
  Banbury Center, Cold Spring Harbor, USA
- Year and Date
  2015-09-18
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Flow cytometric detection of PrPSc in neurons from prion-infected mouse brain2015
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Prion2015
- Place of Presentation
  Colorado State University, Fort Collins, Colorado, USA
- Year and Date
  2015-05-27
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] Comparison of PrPSc-specific staining with two anti-PrP monoclonal antibodies in immuno-cytochemistry2015
- Author(s)
  Tanaka M, Masujin K, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  APPS2015
- Place of Presentation
  Kanazawa-Ongakudo, Kanazawa, Japan
- Year and Date
  2015-09-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02475
[Presentation] フローサイトメトリーによるプリオン感染細胞の検出2014
- Author(s)
  山崎　剛士、鈴木　章夫、長谷部　理絵、堀内　基広
- Organizer
  第59回日本ウイルス学会
- Place of Presentation
  パシフィコ横浜、横浜
- Year and Date
  2014-11-10
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Involvement of CD14 in neuropathogenesis of prion diseases2014
- Author(s)
  Hasebe R, Sakai K, Song C-H, Takahashi Y, Suzuki A, Yamasaki T, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2014
- Place of Presentation
  済州島国際会議場、済州、韓国
- Year and Date
  2014-07-07
- Invited
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Comparison of the anti-prion mechanism of four different anti-prion compounds, anti-PrP monoclonal antibody 44B1, pentosan polysulfate, chlorpromazine, and U18666A, in prion-infected mouse neuroblastoma cells2014
- Author(s)
  Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2014
- Place of Presentation
  済州島国際会議場、済州、韓国
- Year and Date
  2014-07-07
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Analysis of microglial activation state in brains of prion-infected mice.2013
- Author(s)
  Horiuchi, M., Kabuki, H., and Hasebe, R.
- Organizer
  Prion 2013
- Place of Presentation
  Banff, (Fair montanff Spring Hotel) Canada
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Analysis of microglial activation state in brains of prion-infected mice.2013
- Author(s)
  Kabuki, H., Yamasaki, T., Hasebe, R., and Horiuchi, M.
- Organizer
  Asia Pacific Prion Symposium 2013
- Place of Presentation
  Sasebo, Huis Ten Bosch (Japan)
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Reaction of complement factors on scrapie-infected primary-cultured neurons temporarily increases permeability of plasma membrane.2013
- Author(s)
  Hasebe, R., Suzuki A., Yamasaki, T., and Horiuchi, M.
- Organizer
  Prion 2013
- Place of Presentation
  Banff, Fair montanff Spring Hotel (Canada)
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Absence of CD14 delays progression of prion diseases accompanied by increased microglial activation.2013
- Author(s)
  4) Sakai, K., Hasebe, R., Takahashi, Y., Song, C.-H., Suzuki, A., Yamasaki, T., Horiuchi, M.
- Organizer
  Expanding Prion Horizon 2013
- Place of Presentation
  Fort Collins, Colorado State University (USA)
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Analysis of PrPSc accumulation and glial cell activation in brains of prion-infected mice at the early stage of infection2012
- Author(s)
  Horiuchi, M.
- Organizer
  Prion2012
- Place of Presentation
  VU University, Amsterdam, The Netherland
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Construction of mAb132-EGFP fusion proteins as a PrPSc-specific probe2012
- Author(s)
  Suzuki, A., Yamasaki, T., Hasebe, R., and Horiuchi, M
- Organizer
  Asia Pacific Prion Symposium 2012
- Place of Presentation
  Yokoyama,Japan
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Immuno- and cell-therapy as possible treatment for prion diseases2012
- Author(s)
  Horiuchi, M.
- Organizer
  BBSRC Japan Partnering Awards
- Place of Presentation
  The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
- Invited
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Immuno- and cell-therapy as possible treatment for prion diseases2012
- Author(s)
  Horiuchi, M.
- Organizer
  BBSRC Japan Partnering Awards
- Place of Presentation
  The Roslin Institute & Royal (Dick) School of Veterinary Sciences, Edinburgh, UK
- Invited
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Analysis of PrPSc accumulation and glial cell activationin brains of prion-infected mice at the early stage of infection2012
- Author(s)
  Horiuchi, M, Yamasaki, T., Hasebe, R. and Takahashi, Y
- Organizer
  Prion2012
- Place of Presentation
  Amsterdam, The Netherland)UV University Amsterdam
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Analysis of PrPSc accumulation and glial cell activation in brains of prion-infected mice at the early stage of infection2012
- Author(s)
  Horiuchi, M.
- Organizer
  Prion2012
- Place of Presentation
  VU University, Amsterdam, The Netherland
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Immunohistochemical analysis of PrPSc accumulation and activation of astrosytes and microglia in early stage of prion infection2011
- Author(s)
  Takahashi, Y., Song, C.-H., Yamasaki, T., Hasebe, R., and Horiuchi, M
- Organizer
  APPS2011
- Place of Presentation
  Karuizawa,Japan Hotel Marroad Karuizawa
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Detection of newly generataed PrPSc in Neuro2a cells inoculated with fluorescent-dye labeled purified PrPSc2011
- Author(s)
  Yamasaki, T., Garon, G. B., and Horiuchi, M
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo, Japan Sapporo Convention Center
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Characterization of prion infection in differentiated mouse neurospheres.2011
- Author(s)
  Sassa, Y., Yamasaki, T., Hasebe, R., and Horiuchi, M.
- Organizer
  Prion2011
- Place of Presentation
  Fairmont Queen Elizabeth (Canada)
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] 異常型プリオンタンパク質の細胞内増殖2011
- Author(s)
  堀内基広、山崎剛士
- Organizer
  第30回日本認知症学会
- Place of Presentation
  タワーホール船堀(東京)(招待講演)
- Year and Date
  2011-11-11
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Characterization of prion infection in differentiated mouse neurospheres.2011
- Author(s)
  Yamasaki, T., Garon, G. B., and Horiuchi, M.
- Organizer
  XV International Congress of Virology
- Place of Presentation
  Sapporo Convention Center (Japan)
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] 異常型プリオンタンパク質の細胞内増殖2011
- Author(s)
  堀内　基広、山崎　剛士
- Organizer
  第30回日本認知症学会(招待講演)
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] Involvement of the endosomal Cl-/H+ antiporter Clc-5 in the formation of PrP-res in prion-infected Neuro2a mouse neuroblastoma cells.2011
- Author(s)
  Nakamitsu, S., Sassa, Y., Yamasaki, T., Hasebe, R., and Horiuchi, M.
- Organizer
  APPS2011
- Place of Presentation
  Hotel Marroad Karuizawa (Japan)
- Data Source
  KAKENHI-PROJECT-23658233
[Presentation] 異常型プリオン蛋白の細胞内局在2009
- Author(s)
  堀内基広
- Organizer
  大阪大学蛋白質研究所セミナー
- Place of Presentation
  大阪
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Intracellular localization of abnormal isoform of prion protein.2009
- Author(s)
  堀内基広
- Organizer
  "Prion and Virus Infections" BSJ & ABA Joint Symposium
- Place of Presentation
  徳島(アスティ徳島)
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-20658070
[Presentation] マウスプリオンタンパク質ヒスジン186周辺の銅イオン結合部位に関する構造解析2009
- Author(s)
  稲波修、渡辺康子、五十嵐学、伊藤公人、堀内基広、桑原幹典、平岡和佳子
- Organizer
  第148回日本獣医学会学術集会
- Place of Presentation
  鳥取
- Year and Date
  2009-09-25
- Data Source
  KAKENHI-PROJECT-21380185
[Presentation] Intracellular localization of abnormal isoform of prion protein.2009
- Author(s)
  Horiuchi, M.
- Organizer
  "Prion and Virus Infections"BSJ & ABA Joint Symposium
- Place of Presentation
  徳島(アスティ徳島)
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Intracellular localization of disease-snecific nrion protein2009
- Author(s)
  Horiuchi. M., et.al.
- Organizer
  PSymposium on emerging and reemerging infectious diseases
- Place of Presentation
  東京(東京大学)
- Year and Date
  2009-02-17
- Data Source
  KAKENHI-PROJECT-20658070
[Presentation] Intracellular localization of abnormal isoform of prion protein.2009
- Author(s)
  Horiuchi, M.
- Organizer
  "Prion and Virus Infections" BSJ & ABA Joint Symposium
- Place of Presentation
  Tokushima, Japan.
- Year and Date
  2009-10-30
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] 異常型プリオン蛋白の細胞内局在2009
- Author(s)
  堀内基広
- Organizer
  大阪大学蛋白質研究所セミナー2009
- Place of Presentation
  大阪(大阪大学)
- Year and Date
  2009-07-13
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] 遺伝子を持たないプリオンは変異し得るか?2009
- Author(s)
  堀内基広
- Organizer
  第12回日本進化学会
- Place of Presentation
  札幌(北海道大学)
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] 遺伝子を持たないプリオンは変異し得るか?2009
- Author(s)
  堀内基広
- Organizer
  第12回日本進化学会
- Place of Presentation
  札幌(北海道大学)
- Year and Date
  2009-09-03
- Data Source
  KAKENHI-PROJECT-20658070
[Presentation] Identification mAb 132 Rab 11 Merge Chandler Mock of chemotactic factors for migration of mice infected with prions.2009
- Author(s)
  Song, C. -H., Honmou, O., Furuoka, H., Hasebe, R., Horiuchi, M.
- Place of Presentation
  Porto Carras, Greece.
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Intracellular localization of disease-specific prion protein2009
- Author(s)
  Horiuchi, M., et.al.
- Organizer
  PSymposium on emerging and reemerging infectious diseases
- Place of Presentation
  東京(東京大学)
- Year and Date
  2009-02-17
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Intracellular localization of disease-specific prion protein.2009
- Author(s)
  Horiuchi, M., Yamasaki, T.
- Organizer
  Symposium on emerging and reemerging infectious diseases.
- Place of Presentation
  Tokyo, Japan.
- Year and Date
  2009-02-17
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Intracellular localization of disease-specific prion protein2009
- Author(s)
  Horiuchi, M., Yamasaki, T.
- Organizer
  Symposium on emerging and reemerging infectious diseases
- Place of Presentation
  Tokyo Japan
- Year and Date
  2009-02-17
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] マウス神経芽腫細胞Neuro2aにおけるプリオンの細胞間伝播にはエクソソーム以外の因子が関与する2008
- Author(s)
  堀内基広, 他
- Organizer
  第146回日本獣医学会
- Place of Presentation
  宮崎(シーガイアリゾート)
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] PrP^<sc>のaa 81-aa 137の領域はプリオンの感染性に必須である2008
- Author(s)
  堀内塞広, 他
- Organizer
  第56回日本ウイルス学会
- Place of Presentation
  岡山(岡山コンベンションセンター)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20658070
[Presentation] Pathology in guinea pig infected with bovine spongiform encephalopathy.2008
- Author(s)
  Furuoka, H., Horiuchi, M., Sata T.
- Place of Presentation
  Madrid, Spain.
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Prp^<Sc>のaa 81-aa 137の領域はプリオンの感染性に必須である2008
- Author(s)
  堀内基広, 他
- Organizer
  第56回日本ウイルス学会
- Place of Presentation
  岡山(岡山コンベンションセンター)
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Characterization of Cu (II) binding site in C-terminal domain of mouse prion : Site-directed spin labeling study2008
- Author(s)
  Osamu INANAMI, Yasuko WATANABE, Wakako HIROOKA, Yuhei SHIMOYAMA, Motohiro HORIUCHI and Mikinori KUWABARA
- Organizer
  EPR2008 (Biomedical Redox Navigation)
- Place of Presentation
  JAL Resort Sea Hawk Hotel Fukuoka, Kyushu Japan
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] Characterization of Cu(II)binding site in C-terminal domain of mouse prion : Site-directed spin labeling study EPR2008 (Biomedical Redox Navigation2008
- Author(s)
  Osamu INANAMI,Yasuko WATANABE,Wakako HIROOKA,Yuhei SHIMOYAMA,Motohiro HORIUCHI and Mikinori KUWABARA
- Organizer
  JAL Resort Sea Hawk Hotel Fukuoka
- Place of Presentation
  Kyushu Japan
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] マウス神経芽腫細胞Neum2aにおけるプリオンの細胞間伝播にはエクソソーム以外の因子が関与する2008
- Author(s)
  堀内基広, 他
- Organizer
  第146回日本獣医学会
- Place of Presentation
  宮山奇(シーガイアリゾート)
- Year and Date
  2008-09-24
- Data Source
  KAKENHI-PROJECT-20658070
[Presentation] Identication of Cu(II) b inding site incarb ox y-terminal domain of mouse PrPsc Site-directed spin lab study2007
- Author(s)
  Inanami O, Watanabe Y, Hiraoka W, Shimoyama Y, Horiuchi M, Inagaki F and Kuwabara M.
- Organizer
  Society of Electron Spin Scoence and Technology (ISESS SEST)
- Place of Presentation
  Granship (Shizuoka, Japan)
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] プリオンの増殖とその抑制2007
- Author(s)
  堀内基広
- Organizer
  第55回日本ウイルス学会
- Place of Presentation
  札幌(札幌コンベンションセンター)
- Year and Date
  2007-10-21
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] The Protective Effect of Mouse Prion Protein from Metal-Catalyzed Oxidative Stress2007
- Author(s)
  Watanabe Y, Inoue T, Horiuchi M, . Kuwabara M, and Inanami O.
- Organizer
  Free Radical Biology & Medicine(SFRBM's 14^th Annual Meeting)
- Place of Presentation
  Renaissance Hotel(Eashington, D.C., USA)
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] Analysis of pH-sensitivity and conformational stability in mouse prion protein by cysteine-scanning site-directed spin labeling2007
- Author(s)
  Watanabe Y, Hiraoka W, Shimoyama Y, Horiuchi M, Kuwabara M, and Inanami O.
- Organizer
  Society of Electron Spin Scoence and Technology(ISESS-SEST)2007
- Place of Presentation
  Granship(Shizuoka, Japan)
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] Prion propagation and its inhibition2007
- Author(s)
  Horiuchi, M.
- Organizer
  The 14th International Symposium for Zoonosis Control
- Place of Presentation
  札幌(北海道大学)
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Identication of Cu(II)b inding site incarb ox y-terminal domain of mouse PrP^sc Site-directed spin lab study2007
- Author(s)
  Inanami O, Watanabe Y, Hiraoka W, Shimoyama Y, Horiuchi M, Inagaki F and Kuwabara M.
- Organizer
  Society of Electron Spin Scoence and Technology(ISESS-SEST)2007
- Place of Presentation
  Granship(Shizuoka, Japan)
- Year and Date
  2007-11-08
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] プリオンタンパク質C末端領域の新たなCu^2+結合構造の同定2007
- Author(s)
  稲波修、渡辺康子、堀内基広、平岡和佳子、下山雄平、桑原幹典、
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  酪農学園大学(江別市)
- Year and Date
  2007-09-02
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] プリオンタンパク質のpH感受性における塩橋とヒスチジン残基の役割2007
- Author(s)
  渡辺康子、平岡和佳子、下山雄平、堀内基広、桑原幹典、稲波修
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  酪農学園大学(江別市)
- Year and Date
  2007-09-02
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] プリオンタンパク質C末端領域の新たなCu2+結合構造の同定2007
- Author(s)
  稲波修、渡辺康子、堀内基広、平岡和佳子、下山雄平、桑原幹典
- Organizer
  第144回日本獣医学会学術集会
- Place of Presentation
  酪農学園大学(江別市)
- Year and Date
  2007-09-02
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] The Protective Effect of Mouse Prion Protein from Metal-Catalyzed Oxidative Stress2007
- Author(s)
  Watanabe Y, Inoue T, Horiuchi M, Kuwabara M and Inanami O.
- Organizer
  Free Radical Biology & Medicine (SFRBM's 14^<th> Annual Meeting)
- Place of Presentation
  Renaissance Hotel (Ea shington, D.C., USA)
- Data Source
  KAKENHI-PROJECT-19380172
[Presentation] Prion propagation and its inhibition.2007
- Author(s)
  Horiuchi, M.
- Organizer
  The 14th International Symposium for Zoonosis Control.
- Place of Presentation
  Sapporo, Japan.
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] プリオンの増殖とその抑制2007
- Author(s)
  堀内基広
- Organizer
  第55回日本ウイルス学会
- Place of Presentation
  札幌
- Year and Date
  2007-10-22
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] Prion propagation and its Prion propagation and its2007
- Author(s)
  Horiuchi, M.
- Organizer
  The 14^<th> International Symposium for Zoonosis Control
- Place of Presentation
  Sappoor, Japan
- Year and Date
  2007-10-31
- Data Source
  KAKENHI-PROJECT-18208026
[Presentation] PrP polymorphisms of cattle, sheep and goat in Japan2005
- Author(s)
  Naotaka, Ishiguro, Satoshi, Nakamistu, Motohiro, Horiuchi
- Organizer
  Prion Symposium in 2005
- Place of Presentation
  Tendo
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17380180
[Presentation] Analysis of prion infection in primary cortical neurons
- Author(s)
  Fujiwara A, Sassa Y, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Prion2014
- Place of Presentation
  先端国際大学、トリエステ、イタリア
- Year and Date
  2014-05-27 – 2014-05-29
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] Analysis of mechanism for PrPSc-specific detection by anti-PrP monoclonal antibody mAb132
- Author(s)
  Suzuki A, Yamasaki T, Hasebe R, Horiuchi M
- Organizer
  Prion2014
- Place of Presentation
  先端国際大学、トリエステ、イタリア
- Year and Date
  2014-05-27 – 2014-05-29
- Data Source
  KAKENHI-PROJECT-23248050
[Presentation] igh throughput detection of PrPSc from prion-infected cells without PK-treatment: cell-based ELISA for novel screening method for anti-prion compounds
- Author(s)
  Shan Z, Yamasaki T, Suzuki A, Hasebe R, Horiuchi M
- Organizer
  Asian Pacific Prion Symposium 2014
- Place of Presentation
  済州島国際会議場、済州、韓国
- Year and Date
  2014-07-07 – 2014-07-08
- Data Source
  KAKENHI-PROJECT-23248050

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Horiuchi Motohiro 堀内 基広

HORIUCHI Motohiro 堀内 基広

堀内 基弘 ホリウチ モトヒロ

Research Projects

Research Products

Co-Researchers

プリオン感染に脆弱な神経細胞種の同定と誘導される神経細胞死の分子機構の解析Principal Investigator

Principal Investigator

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Review Section

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One health approach for surveillance of foodborne and antimicrobial resistant bacterial in MongoliaPrincipal Investigator

Principal Investigator

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Review Section

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Studies on the control of disease progression of prion diseases by transition of glial cell polarizationPrincipal Investigator

Principal Investigator

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Review Section

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Role of stress-induced transcription factor ATF3 on neurodegeneration of prion diseasesPrincipal Investigator

Principal Investigator

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Review Section

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Identification of MSC subpopulations that have therapeutic potential for neurodegenerative disordersPrincipal Investigator

Principal Investigator

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Elucidation of the mechanism for neurodegeneration in prion diseases through neuron-glia cross-talkPrincipal Investigator

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Role of functional change of microglia in neuropathogenesis of prion diseasesPrincipal Investigator

Principal Investigator

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Identification of factors that involved in migration of mesenchymal stem cells to lesions of neurodegenerative diseasesPrincipal Investigator

Principal Investigator

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Principal Investigator

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再生医療を応用したプリオン病治療モデルの確立Principal Investigator

Principal Investigator

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Principal Investigator

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Elucidation of the mechanism on the formation of early pathological lesion of prion diseasesPrincipal Investigator

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Principal Investigator

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Horiuchi Motohiro 堀内基広

HORIUCHI Motohiro 堀内基広

堀内基弘ホリウチモトヒロ