TAKAKUWA Yuichi 高桑雄一

… Alternative Names

Researcher Number	40113740
External Links
Affiliation (based on the past Project Information) *help	1997 – 2016: 東京女子医科大学, 医学部, 教授 1995 – 1996: 東京女子医科大学, 教授 1991: 東京女子医科大学, 教授 1988 – 1989: 北海道大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Biological Sciences / General medical chemistry / Infectious disease medicine / General medical chemistry / Parasitology (including Sanitary zoology) Except Principal Investigator Applied veterinary science / Clinical veterinary science / Infectious disease medicine / Orthopaedic surgery / Applied molecular and cellular biology … More
Keywords	Principal Investigator 赤血球 / バンド3 / マラリア原虫 / レクチン / 赤血球変形能 / バンド3蛋白質 / マラリア / 4.1タンパク / PSリポソーム / 自己相関蛍光測定法(FCS) … More Except Principal Investigator 膜骨格 / 赤血球 / 赤血球膜 / CD44 / 4.1蛋白質 / 膜蛋白質 / バンド3 / 変形能 / 小胞輸送 / 小胞体 / 牛 / 遺伝性疾患 / ATP / 膜骨格蛋白 / membrane skeleton / ankyrin / protein 4.1R / protein 4.1G / calmodulin / グリコフォリン / リン酸化 / 膜移行 / 赤芽球系分化 / 4.1R / 赤芽球 / 細胞膜 / スペクトリン / マラリア原虫 / Band 3 / GATA-1 / 骨芽細胞 / 細胞接着 / protein 4.1 / アンキリン / band 3 / red blood cell / protein4.1R / calcium / erythroblast / zebrafish / Coracle / HeLa cell / 植物凝集素 / イノシト-ル燐脂質 / 時間分解顕微蛍光法 / ピコ秒パルスレ-ザ- / ヘキサゴナル相 / ジアシルグリセロ-ル / リポソ-ム / 蛍光寿命 / 膜タンパク質 / グライコフォリン / ゴルジ装置 / グライコフォリンC / タンパク質分解 / 細胞間ジャンクション / タイトジャンクション / クローディン / 組織破壊 / 低形成 / 犬 / 猫 / ヒト赤芽球 / 脱核 / マクロファージ / centrosome / CD34 / 細胞質分裂 / 細胞骨格蛋白質 / 膜蛋白 / Glycophorin A / Cytokinesis / トラフィック / 疾患 / 遺伝 / アニオン交換輸送体1 / トランスジェニックマウス / 変形能(膜伸展性) / 糖化 / リボース / ペントシジン / 寿命 / 脂質過酸化 / 組織傷害 / ヒドロキシノネナール / 酸化障害 / マラリア / プリンヌクレオチド受容体 / 赤血球膜骨格 / PKAリン酸化 / デマチン / 膜安定性 / 4,1蛋白 / イノシトールリン脂質 / Caイオン / 生体膜 / 合成膜 / 物質認識 / 信号伝達 / 選択輸送 / biological membrane / synthetic membrane / recognition of materials / signal transmission / selective transport / 陰イオン輸送 / 酸塩基平衡 / 黒毛和種牛 / Red cells / Membrane proteins / Hereditary diseases / Anion transport / Acid-base balance / Membrane skeleton / Japanese black cattle / 遺伝子治療 / 転写因子 / プロモーター / エンハンサー / 赤芽球系造血 / 家畜 / Gene therapy / transcription factors / Promoters / Enhancers / Inberited disorders / Hematopoiesis / 骨リモデリング / 膜貫通蛋白 / CO44 / 骨リモデーリング / 骨芽細胞(正常ヒト) / 骨 / 細胞膜裏打ち構造 / 刺激分泌連関 / bone remodeling / osteoblast / 遺伝性溶血性貧血 / プロテアゾーム / 遺伝性溶血性貧 / プロテアソーム / 遺伝性バンド3欠損症 / red cell membranes / congenital hemolytic anemia / proeasome / vesicle trafficking / cattle / 虚血膵 / 赤血球連銭形成 / 赤血球変形態 / 酸化的ストレス / 赤血球膜荷電 / 赤血球膜骨蛋白 / 連銭形成 / 膜荷電 / 赤血球膜蛋白 / 赤血球脂質膜 / 阻血再灌流傷害 / 赤血球膜脂質 / 阻血再潅流 / 赤血球rouleau現象 / ischemic pancreas / red cell rouleau formation / red cell deformability / oxidative stress / red cell membrane charge / cytoskeletal red cell protein / 4.1G / I型コラーゲン / トランスフェクション / 共焦点レーザー顕微鏡 / ノックアウトマウス / Osteoblast / Type I collagen / cell adhesion / Transfection / Laser Confocal Microscopy / カルモジュリン / カルシュウム / PDZ ドメイン / Protein4.1 / Calmodulin / Calcium / PDZドメイン / 分子間相互作用 / calmodulim / POZ domain / 結晶構造 / グリコフォリンC / p55 / X線結晶構造解析 / resonant mirror detection method / crystal structure / membrane skeletal protein / erythrocyte / 赤芽球分化 / 培養細胞 / 膜骨格タンパク質 / erythroid development / membrane trafficking / intracellular vesicles / cell culture / protein 4.1R^<135> / キメラ蛋白質 / HeLa細胞 / FERM domain / ezrin / chimera protein / resonant mirror detection / FERMdomain / protein4.1G / chimera Less

Studies on PKA phosphorylation events in host red cells during invasion by Plasmodium falciparum
- Principal Investigator
  
  Koshino Ichiro
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tokyo Women's Medical University
An inhibitory effect of cholesterol on expressing eat me signals in human erythrocyte membranePrincipal Investigator
- Principal Investigator
  
  Takakuwa Yuichi
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Women's Medical University
Studies on the mechanism by which malaria parasites invade erythrocytes using host erythrocyte-derived ATP
- Principal Investigator
  
  KOSHINO Ichiro
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tokyo Women's Medical University
Exploration of a novel role for lidocaine as a wide range spectrum anti-infection drugPrincipal Investigator
- Principal Investigator
  
  TAKAKUWA Yuichi
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Infectious disease medicine
- Research Institution
  Tokyo Women's Medical University
From the ER to the plasma membrane : Vesicular transport of membrane skeleton units and the diseases
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Clinical veterinary science
- Research Institution
  Hokkaido University
An ATP-dependent mechanism protects spectrin against glycation in human erythrocytes
- Principal Investigator
  
  MANNO Sumie
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Women's Medical University
組織障害の新指標 : 膜インターフェースにおける骨格蛋白質のヒドロキシノネナール修飾
- Principal Investigator
  
  稲葉睦
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Clinical veterinary science
- Research Institution
  Hokkaido University
Effect of erythrocyte membrane lipid dynamism on malaria invasionPrincipal Investigator
- Principal Investigator
  
  TAKAKUWA Yuichi
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Parasitology (including Sanitary zoology)
- Research Institution
  Tokyo Women's Medical University
ヒト赤芽球の脱核機序に関する研究
- Principal Investigator
  
  澤田賢一
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Hematology
- Research Institution
  Akita University
マラリア原虫の侵入を許す赤血球(宿主細胞側)の必要・十分条件の解明/予防と治療の手がかりを探るPrincipal Investigator
- Principal Investigator
  
  高桑雄一
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
組織の破壊と低形成-細胞間ジャンクションの分子構築破綻と疾患の遺伝的基盤-
- Principal Investigator
  
  滝口満喜
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Clinical veterinary science
- Research Institution
  Rakuno Gakuen University
  Hokkaido University
マラリア原虫の侵入を許す赤血球(宿主細胞側)の必要・十分条件の解明Principal Investigator
- Principal Investigator
  
  高桑雄一
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Women's Medical University
Integrative biological studies on the diversity of membrane skeletal proteins structure in signal transduction
- Principal Investigator
  
  NUNOMURA Wataru
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Tokyo Women's Medical University
膜タンパク質のポストゴルジ/ERレトリーバル小胞輸送における新規分子機構の構築
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Applied molecular and cellular biology
- Research Institution
  Hokkaido University
Molecular mechanisms for the assembly of the red cell membrane skeleton during erythroid cell development
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  HOKKAIDO UNIVERSITY
Molecular mechanism for the assembly of red cell membrane skeletons based on pathobiology of congenital hemolytic anemia in cattle
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
Study on mechanism of ischemia-reperfusion injury in ischemic pancreas, and development of its preventive modality and viability assessment method.
- Principal Investigator
  
  TERAOKA Satoshi
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  TOKYO WOMEN'S MEDICAL UNIVERSITY
Structural dynamism and analysis of functional domain of membrane proteins in signal transduction.
- Principal Investigator
  
  NUNOMURA Wataru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Tokyo Women's Medical University
Function of membrane skeletal protein (protein 4.1) in osteoblast for cell adhesion and secretion of local factor
- Principal Investigator
  
  HORIKOSHI M
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  TOKYO WOMEN'S MEDICAL UNIVERSITY
単一分子によるタンパクと生体膜の結合解析:膜骨格タンパクと赤血球膜をモデルとしてPrincipal Investigator
- Principal Investigator
  
  高桑雄一
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General medical chemistry
- Research Institution
  Tokyo Women's Medical University
Applications of Tissue-specific Transcription Factor in Animal Gene Therapy
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
Contribution of membrane skeletal protein in osteoblast for bone remodeling
- Principal Investigator
  
  HORIKOSHI Mariko, 堀越万里子
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Tokyo Women's Medical University
Molecular and Biochemical Studies on Compensatory Mechanisms for Total Band 3 Deficiency in Japanese Black Cattle
- Principal Investigator
  
  INABA Mutsumi
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied veterinary science
- Research Institution
  The University of Tokyo
Synthesis and Application of Intelligent interface System
- Principal Investigator
  
  FURUSAKI Shintaro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  生物・生体工学
- Research Institution
  The University of Tokyo
時間分解顕微蛍光法によるトランスミッタ-放出機構の解析
- Principal Investigator
  
  石俊輝雄
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
イノシト-ル燐脂質代謝を介するグリコフォリンの赤血球膜機能調節機構の解明
- Principal Investigator
  
  石橋輝雄
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University
イノシトール燐脂質代謝を介するグリコフォリンの赤血球膜機能調節機構の解明
- Principal Investigator
  
  石橋輝雄
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Hokkaido University

[Book] 血液フロンティア2014
- Author(s)
  越野一朗、高桑雄一
- Total Pages
  6
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24659485
[Book] マラリア原虫の赤血球侵入メカニズム血液フロンティア2014
- Author(s)
  越野一朗、高桑雄一
- Publisher
  医薬ジャーナル社
- Data Source
  KAKENHI-PROJECT-24659485
[Journal Article] A method for detailed analysis of the structure of mast cell secretory granules by negative contrast imaging2016
- Author(s)
  Shotaro Tanaka†*, Yuichi Takakuwa
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Pages: 1-8
- DOI
  10.1038/srep23369
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460375
[Journal Article] ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia.2016
- Author(s)
  Nobuto Arashiki, Yuichi Takakuwa, Hitoshi Kanno
- Journal Title
  
  Haematologica.
  
  Volume: 印刷中 Pages: 559-565
- DOI
  10.3324/haematol.2016.142273
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460375, KAKENHI-PROJECT-25461609, KAKENHI-PLANNED-15H05909, KAKENHI-PROJECT-26221308
[Journal Article] 蛍光相関分光法FCSを用いた細胞内分子間相互作用解析2015
- Author(s)
  田中正太郎、高桑雄一
- Journal Title
  
  細胞
  
  Volume: 47 Pages: 49-49
- NAID
  40020490185
- Data Source
  KAKENHI-PROJECT-25460375
[Journal Article] ヒト赤血球の寿命を規定するメカニズム2014
- Author(s)
  高桑雄一、新敷信人、斎藤将樹
- Journal Title
  
  臨床血液
  
  Volume: 55 Pages: 643-643
- NAID
  130004501864
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460375
[Journal Article] マラリア原虫の赤血球侵入メカニズム2014
- Author(s)
  越野一朗、高桑雄一
- Journal Title
  
  血液フロンティア
  
  Volume: 24 Pages: 90-95
- Data Source
  KAKENHI-PROJECT-25460375
[Journal Article] Membrane Peroxidation and Methemoglobin Formation are Both Necessary for Band 3 Clustering: Mechanistic Insights into Human Erythrocyte Senescence2013
- Author(s)
  Arashiki N, Kimata N, Manno S, Mohandas N, Takakuwa Y.
- Journal Title
  
  Biochemistry
  
  Volume: 52 Pages: 5760-5769
- DOI
  10.1021/bi400405p
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659485, KAKENHI-PROJECT-25460375
[Journal Article] Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction2012
- Author(s)
  Ichiro Koshino
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 3524435250-3524435250
- DOI
  10.1074/jbc.m111.305441
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591112, KAKENHI-PROJECT-24659485
[Journal Article] Identification of a novel role for dematin in regulating red cell membrane function by modulating spectrin-actin interaction2012
- Author(s)
  Koshino, I., Mohandas, N., andTakakuwa, Y.
- Journal Title
  
  J. Biol. Chem
  
  Volume: 287 Pages: 35244-35250
- Data Source
  KAKENHI-PROJECT-22591112
[Journal Article] Marked defference in membrane protein binding properties of the two isoforms of protein 4. 1R expressed at early and late stages of erythroid defferentiation2009
- Author(s)
  Nunomura W, Parra M, Hebiguchi M, Sawada K, Mohandas N, Takakuwa Y
- Journal Title
  
  Biochem J 417
  
  Pages: 141-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] Marked difference in membrane-protein-binding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation2009
- Author(s)
  Nunomura, W., Parra, M., Hebiguchi, M., Sawada, K., Mohandas, N., Takakuwa, Y.
- Journal Title
  
  Biochem. J. 417
  
  Pages: 141-148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19208027
[Journal Article] Dynamics of human erythroblast enucleation.2008
- Author(s)
  Hebiguchi Miwa, Takakuwa Y, et. al
- Journal Title
  
  Int. J. Hematol
  
  Pages: 498-507
- NAID
  10023971140
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] Functional evidence for presence of lipid rafts in erythrocyte membranes: Gsαin rafts is essential for signal transduction2008
- Author(s)
  Kamata K, Manno S, Ozaki M, Takakuwa Y
- Journal Title
  
  Am J Hematol
  
  Pages: 371-375
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] 赤血球膜とマラリア原虫検査と技術2008
- Author(s)
  越野一朗、高桑雄一
- Pages
  164-166
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] 赤血球膜とマラリア原虫2008
- Author(s)
  高桑雄一
- Journal Title
  
  検査と技術 36
  
  Pages: 164-166
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590408
[Journal Article] Erythrocyte Shape Change Prevents Plasmodium falciparum Invasion Membrane2007
- Author(s)
  Boampong J N, Manno S, Koshino I, Takakuwa Y
- Journal Title
  
  32
  
  Pages: 95-102
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] 翻訳後修飾による赤血球膜機能の調節2007
- Author(s)
  萬野純恵、高桑雄一
- Journal Title
  
  膜 32
  
  Pages: 122-128
- NAID
  130005077795
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] 翻訳後修飾による赤血球膜機能の調節膜2007
- Author(s)
  萬野純恵、高桑雄一
- Journal Title
  
  32
  
  Pages: 122-128
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Journal Article] Erythrocyte Shape Change Prevents Plasmodium Falciparum Invasion2007
- Author(s)
  Boampong JN, Manno S, Koshino I, Takakuwa Y
- Journal Title
  
  Membrane 32
  
  Pages: 95-102
- NAID
  10018865838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590408
[Journal Article] Regulation of ankyrin interaction with CD44 by protein 4.1 in HeLa cells2006
- Author(s)
  Hattori, M., Nunomura, W., Ito, E., Ohra, H., Takakuwa, Y.
- Journal Title
  
  Membrane 31
  
  Pages: 107-114
- NAID
  10017313513
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570123
[Journal Article] Regulation of protein 4.1R interactions with membrane proteins by Ca2+ and calmodulin.2006
- Author(s)
  Nunomura W, Takakuwa Y
- Journal Title
  
  Front Biosci 11(5)
  
  Pages: 1522-1539
- Data Source
  KAKENHI-PROJECT-17659286
[Journal Article] Regulation of ankyrin interaction with CD44 by protein 4.1 in HeLa cells.2006
- Author(s)
  Hattori, M., Nunomura, W., Ito, E., Ohta, H., Takakuwa, Y.
- Journal Title
  
  Membrane 31(2)
  
  Pages: 107-114
- NAID
  10017313513
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15570123
[Journal Article] Regulation of protein 4.1R interactions with membrane proteins by Ca^<2+> and calmodulin2006
- Author(s)
  Nunomura, W., Takakuwa, Y.
- Journal Title
  
  Frontiers in BioScience 11
  
  Pages: 1522-1539
- Data Source
  KAKENHI-PROJECT-15570123
[Journal Article] 赤血球はマラリア原虫の侵入に抵抗できるか2006
- Author(s)
  高桑雄一
- Journal Title
  
  膜 31
  
  Pages: 253-257
- NAID
  10020361721
- Description
  「研究成果報告書概要(和文)」より
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18590408
[Journal Article] Regulation of protein 4.1R interactions with membrane proteins by Ca^<2+> and calmodulin2006
- Author(s)
  Nunomura W., Takakuwa Y.
- Journal Title
  
  Frontiers in BioScience 11
  
  Pages: 1522-1539
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570123
[Journal Article] 赤血球はマラリア原虫の侵入に抵抗できるか2006
- Author(s)
  高桑雄一
- Journal Title
  
  MEMBRANE 31
  
  Pages: 253-257
- NAID
  10020361721
- Data Source
  KAKENHI-PROJECT-18590408
[Journal Article] Modulations occur in erythrocite membrane surface properties following malaria parasite invasion.2005
- Author(s)
  Aryee NA, Koshino T, Manno S, Takakuwa Y.
- Journal Title
  
  Membrane 30
  
  Pages: 157-164
- Data Source
  KAKENHI-PROJECT-16017296
[Journal Article] Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation us from a patient with thymoma-associated pure red cell aplasia.2005
- Author(s)
  Manno S, Takakuwa Y, Mohandas N
- Journal Title
  
  J Biol Chem 280(9)
  
  Pages: 7581-7587
- Data Source
  KAKENHI-PROJECT-17659286
[Journal Article] Modulation Occur in Erythrocyte Membrane Surface Properties Following Malaria Parasite Invasion2005
- Author(s)
  Aryee N.A., Koshino I., Manno S., Takakuwa Y.
- Journal Title
  
  Membrane 30・3(in press)
- Data Source
  KAKENHI-PROJECT-16017296
[Journal Article] Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.2005
- Author(s)
  Manno S, Takakuwa Y, Mohandas N.
- Journal Title
  
  J Biol Chem 280
  
  Pages: 7581-7587
- Data Source
  KAKENHI-PROJECT-17659286
[Journal Article] Modulation of Erythrocyte Membrane Mechanical Function by Protein 4.1 Phosphorylation2005
- Author(s)
  Manno S., Takakuwa Y., Mohandas N.
- Journal Title
  
  Journal of Biological Chemistry 280・9
  
  Pages: 7581-7587
- Data Source
  KAKENHI-PROJECT-16017296
[Journal Article] Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation.2005
- Author(s)
  Manno S, Takakuwa Y, Mohandas N.
- Journal Title
  
  J.Biol.Chem 280
  
  Pages: 7581-7487
- Data Source
  KAKENHI-PROJECT-16017296
[Journal Article] Transgenic over-expression of GATA-1 mutant lacking N-finger domain causes hemolytic syndrome in mouse erythroid cells.2005
- Author(s)
  Nakano M, Ohneda K, Yamamoto-Mukai H, Slumizu R, Ohneda O, Ohmura S, Suzuki M, Tsukamoto S, Yanagawa T, Yoshida H, Takakuwa Y, Yamamoto M
- Journal Title
  
  Genes Cells 10(1)
  
  Pages: 47-62
- Data Source
  KAKENHI-PROJECT-17659286
[Journal Article] Protein 4.1 as a modulator of membrane skeletal organization and function of erythrocyte.2003
- Author(s)
  Nunomura, W., Takakuwa Y.
- Journal Title
  
  Recent Research Developments in Cell Research 1
  
  Pages: 67-76
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15570123
[Journal Article] Regulation of red cell membrane protein interactions : implications for red cell function2001
- Author(s)
  An XI, Takakuwa Y, Monhandas N, et al.
- Journal Title
  
  Current Opinion in Hematology 8
  
  Pages: 80-84
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Regulation of red cell membrane protein interactions : implications for red cell function2001
- Author(s)
  An XL, Takakuwa Y, Monhandas N, et al.
- Journal Title
  
  Current Opinion in Hematology 276-38
  
  Pages: 35778-35785
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization2000
- Author(s)
  Bong-Gyoon Han, Yuichi Takakuwa, Bing K.Jap, et al.
- Journal Title
  
  Nature Structural Biology 7
  
  Pages: 871-875
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Regulation of protein 4.1R, p55, and glycophorin C ternary complex in human erythrocyte membrane.2000
- Author(s)
  Wataru Nonomura, Yuichi Takakuwa, Narla Mohandas, et al.
- Journal Title
  
  The Journal of Biological Chemistry 275-32
  
  Pages: 24540-24546
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] C^<2+>-dependent and Ca^<2+>-independent calmodulin bindings sites in erythrocyte protcin 4.1p2000
- Author(s)
  Wataru Nonomura, Yuichi Takakuwa, John G.Conboys, et al.
- Journal Title
  
  The Journal of Biological Chemistry 275-9
  
  Pages: 6360-6367
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Protein 4.1, a multifunctional protein of the erythrocyte membrane skeleton : Structure and functions in erythrocytes and nonerythroid cells2000
- Author(s)
  Yuichi Takakuwa
- Journal Title
  
  International Journal of HEMATOLOGY 72
  
  Pages: 298-309
- NAID
  10007316925
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Protein 4.1, a multifunctional protein of the erythrocyte membrane skeleton : Structure and functions in erythrocytes and nonerythroid cells.2000
- Author(s)
  Yuichi Takakuwa
- Journal Title
  
  International Journal of HEMATOLOGY 72
  
  Pages: 298-309
- NAID
  10007316925
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Ca^<2+>-dependent and Ca^<2+>-independent calmodulin bindings sites in erythrocyte protein 4.12000
- Author(s)
  Wataru Nonomura, Yuichi Takakuwa, John G.Conboys, et al.
- Journal Title
  
  The Journal of Biological Chemistry 275
  
  Pages: 6360-6367
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization2000
- Author(s)
  Bong-Gyoon Hah, Yuichi Takakuwa, Bing K.Jap, et al.
- Journal Title
  
  Structural Biology 7
  
  Pages: 871-875
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Regulation of protein 4.1R, p55, and glycophorin C ternary complex in human erythrocyte membrane2000
- Author(s)
  Wataru Nonomura, Yuichi Takakuwa, Narla Mohandas, et al.
- Journal Title
  
  The Journal of Biological Chemistry 275
  
  Pages: 24540-24546
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12470248
[Journal Article] Disruption of lipid rafts by lidocaine inhibits erythrocyte invasion by Plasmodium falciparum Exp.
- Author(s)
  Koshino I, Takakuwa Y
- Journal Title
  
  Parasitol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 赤血球膜機能に対する甲状腺ホルモンの作用2017
- Author(s)
  武崎紗恵子、越野一朗、高桑雄一
- Organizer
  日本膜学会第39年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京都新宿区）
- Year and Date
  2017-05-26
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] 赤血球膜骨格構造へのPKA/PKCリン酸化による影響2016
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台国際センター（宮城県仙台市）
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] ATP released from host erythrocytes is important in invasion of red cells by Plasmodium falciarum2015
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第88回日本生化学会大会
- Place of Presentation
  神戸国際会議場（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] ATP11C Encodes a Major Flippase in Human Erythrocyte and Its Genetic Defect Causes Congenital Non-Spherocytic Hemolytic Anemia2015
- Author(s)
  Arashiki Nobuto, Takakuwa Yuichi, Kanno Hitoshi
- Organizer
  57th Annual Meeting and Exposition of American Society of Hematology
- Place of Presentation
  Orland, FL, USA
- Year and Date
  2015-12-06
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] Maintenance, regulation and disorder of asymmetric distribution of phospholipids in the bilayer of human erythrocyte membranes2015
- Author(s)
  Yuichi Takakuwa, Nobuto Arashiki, Ichiro Koshino
- Organizer
  Gordon Research Conference
- Place of Presentation
  ニューハンプシャー（アメリカ）
- Year and Date
  2015-06-28
- Invited
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] 赤血球膜におけるリン脂質スクランブラーゼPLSCR1の多量体形成2015
- Author(s)
  新敷信人, 高桑雄一
- Organizer
  日本膜学会第37年会
- Place of Presentation
  早稲田大学（東京都新宿区）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] ATP derived from host red cells plays an important role in red cell invasion by Plasmodium falciaprum2015
- Author(s)
  Ichiro Koshino, Yuichi Takakuwa
- Organizer
  Gordon Research Conference
- Place of Presentation
  ニューハンプシャー（アメリカ）
- Year and Date
  2015-06-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] Maintenance, Regulation, and Disorder of Asymmetric Distribution of Phospholipids in the Bilayer of Human Erythrocyte Membrane2015
- Author(s)
  Yuichi Takakuwa, Nobuto Arashiki, Ichiro Koshino
- Organizer
  Gordon Research Conference, Red cells
- Place of Presentation
  Holderness, NH, USA
- Year and Date
  2015-07-02
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 赤血球膜骨格-膜貫通蛋白質間結合へのPKAリン酸化の影響2015
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第37年会
- Place of Presentation
  早稲田大学西早稲田キャンパス（東京都新宿区）
- Year and Date
  2015-05-14
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] New insight into the regulatory mechanism of membrane lipid scrambling in human erythrocyte: Inhibitory effect of cholesterol on PLSCR1-mediated phospholipid scrambling2015
- Author(s)
  Nobuto Arashiki, Yuichi Takakuwa
- Organizer
  Gordon Research Conference, Red Cells
- Place of Presentation
  Holderness, NH, USA
- Year and Date
  2015-06-29
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 赤血球膜骨格-膜貫通蛋白質間結合へのPKAリン酸化の影響2015
- Author(s)
  越野一朗, 高桑雄一
- Organizer
  日本膜学会第37年会
- Place of Presentation
  早稲田大学（東京都新宿区）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] ヒト赤血球膜におけるリン脂質スクランブリングのコレステロールによる抑制機構2015
- Author(s)
  新敷信人, 高桑雄一
- Organizer
  第57回日本脂質生化学会
- Place of Presentation
  一橋大学一橋講堂（東京都千代田区）
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] マスト細胞分泌顆粒の分類の試み～構造および結合タンパク質に基づく～2015
- Author(s)
  田中正太郎, 高桑雄一
- Organizer
  日本膜学会第37年会
- Place of Presentation
  早稲田大学（東京都新宿区）
- Year and Date
  2015-05-15
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] ヒト赤血球膜におけるスクランブラーゼPLSCR1のリン脂質輸送メカニズム2015
- Author(s)
  新敷信人, 高桑雄一
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] マスト細胞分泌顆粒の分類の試み～構造および積荷タンパク質に基づく～2015
- Author(s)
  田中正太郎, 高桑雄一
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 熱帯性マラリア原虫は宿主赤血球由来のATPを利用して赤血球に侵入する2015
- Author(s)
  越野一朗, 高桑雄一
- Organizer
  第38回日本分子生物学会年会第88回日本生化学会大会合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県神戸市）
- Year and Date
  2015-12-02
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] マラリア原虫の赤血球侵入メカニズム2014
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第36年会
- Place of Presentation
  早稲田大学（東京都・新宿区）
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] コレステロール移動亢進が溶血の原因となる可能性の検討2014
- Author(s)
  新敷信人、高桑雄一
- Organizer
  第56回日本脂質生化学会
- Place of Presentation
  近畿大学東大阪キャンパス（大阪府・東大阪市）
- Year and Date
  2014-06-07
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 赤血球膜-リポタンパク質間におけるコレステロール移動の解析2014
- Author(s)
  新敷信人、高桑雄一
- Organizer
  日本膜学会第36年会
- Place of Presentation
  早稲田大学（東京都・新宿区）
- Year and Date
  2014-05-12
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] マラリア原虫の赤血球侵入におけるATPの役割に関する検討2014
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第36年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] 赤血球膜-リポタンパク質間コレステロール移動におけるハプトグロビンの役割2014
- Author(s)
  新敷信人、高桑雄一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会議場（京都府・京都市）
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] PKAリン酸化による赤血球膜骨格の膜への結合の変化2014
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  国立京都国際会議場（京都府・京都市）
- Year and Date
  2014-10-18
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 膜リン脂質非対称性の維持機構における膜コレステロールの役割2013
- Author(s)
  斎藤将樹、萬野純恵、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] 蛍光標識抗体を利用した細胞内在性タンパク質イメージング技術の開発2013
- Author(s)
  田中正太郎、高桑雄一
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 生体膜の本質に迫る2013
- Author(s)
  高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] Phospholipid scramblase 1を介するリン脂質scramblingにおけるヒト赤血球膜コレステロールの抑制効果の検討2013
- Author(s)
  斎藤将樹、萬野純恵、高桑雄一
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] Phospholipid scramblase 1を介するリン脂質scramblingにおけるヒト赤血球膜コレステロールの抑制効果の検討2013
- Author(s)
  斎藤将樹、萬野純恵、高桑雄一
- Organizer
  第55回日本脂質生化学会
- Place of Presentation
  仙台
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] Anti-viral effects of lidocaine on feline immunodeficiency virus (FIV)2013
- Author(s)
  越野一朗、越野（後藤）裕子、辻本元、高桑雄一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] 脂質過酸化によってバンド３タンパク質に生じるメトヘモグロビンとの結合様式の変化のメカニズム2013
- Author(s)
  新敷信人、萬野純恵、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] 膜リン脂質非対称性の維持機構における膜コレステロールの役割2013
- Author(s)
  斎藤将樹、萬野純恵、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 蛍光標識抗体を利用して膜骨格タンパク質のあるがままの挙動を観察する2013
- Author(s)
  田中正太郎、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] Phospholipid scramblase 1 (PLSCR1)を介したリン脂質のscrambling機構の検討2013
- Author(s)
  斎藤将樹、萬野純恵、高桑雄一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] 蛍光標識抗体を利用した細胞内在性タンパク質イメージング技術の開発2013
- Author(s)
  田中正太郎、高桑雄一
- Organizer
  第65回日本細胞生物学会大会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] Anti-viral Effects of Lidocaine on Feline Immunodeficiency Virus (FIV)2013
- Author(s)
  越野一朗、越野（後藤）裕子、辻本　元、高桑雄一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 赤血球‐リポタンパク質間のコレステロール移動のメカニズム2013
- Author(s)
  新敷信人、高桑雄一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 蛍光標識抗体を利用して膜骨格タンパク質のあるがままの挙動を観察する2013
- Author(s)
  田中正太郎、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 脂質過酸化によってバンド3タンパク質に生じるメトヘモグロビンとの結合様式の変化のメカニズム2013
- Author(s)
  新敷信人、萬野純恵、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 生体膜の本質に迫る2013
- Author(s)
  高桑　雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] 赤血球-リポタンパク質間のコレステロール移動のメカニズム2013
- Author(s)
  新敷信人、高桑雄一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24659485
[Presentation] Phospholipid scramblase 1 (PLSCR1) を介したリン脂質のscrambling機構の検討2013
- Author(s)
  斎藤将樹、萬野純恵、高桑雄一
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 局所麻酔薬リドカインによる抗ウイルス効果の検討2013
- Author(s)
  越野一朗、越野（後藤）裕子、辻本　元、高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] 生体膜の本質に迫る2013
- Author(s)
  高桑雄一
- Organizer
  日本膜学会第35年会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-25460375
[Presentation] Erythrocyte raft-dependent signal transduction pathway involved in Plasmodium falciparum invasion of erythrocytes2011
- Author(s)
  Ichiro Koshino, Yuichi Takakuwa
- Organizer
  International Union of Microbiological Societies Congress 2011
- Place of Presentation
  Sapporo
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] Identification of a novel role for dematin in regulating red cell membrane mechanical function by PKA phosphorylation-dependent modulation of spectrin-actin interaction2011
- Author(s)
  Ichiro Koshino, Narla Mohandas, Yuichi Takakuwa
- Organizer
  Red Cell Club Meeting 2011
- Place of Presentation
  Philadelphia, USA
- Year and Date
  2011-10-14
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] Identification of the GPCR-agonist utilized by Plasmodium falciparum2011
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2011-09-24
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] マラリア原虫が赤血球侵入時に利用する情報伝達経路の解明2011
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第33年会
- Place of Presentation
  東京
- Year and Date
  2011-05-12
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] デマチンのPKAリン酸化による赤血球膜骨格機能の調節2010
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第32年会
- Place of Presentation
  産総研臨海副都心センター(東京都)
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] マラリア原虫の侵入における赤血球膜骨格蛋白質デマチンの役割2010
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第83回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2010-12-08
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] 蛍光相関分光法を用いた膜骨格蛋白質 protein 4.1の細胞内動態の観察2010
- Author(s)
  田中正太郎, 高桑雄一
- Organizer
  日本膜学会第32年会
- Place of Presentation
  産業技術総合研究所臨界副都心センター
- Year and Date
  2010-05-14
- Data Source
  KAKENHI-PROJECT-19208027
[Presentation] Clever mechanism for malaria parasite invasion of human erythrocytes : innocent participation of the erythrocyte raft-dependent signal transduction pathway2010
- Author(s)
  越野一朗、高桑雄一
- Organizer
  3^<rd>. Indo-Japanese International Joint Symposium on Overcoming Intractable Infectious Diseases Prevalent in Asian Countries
- Place of Presentation
  東京理科大学森戸記念館(東京都)
- Year and Date
  2010-12-14
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] 赤血球におけるSpectrinの糖化部位の解析と糖化防御機構の解明2009
- Author(s)
  萬野純恵、高桑雄一
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸ポートアイランド(兵庫県)
- Year and Date
  2009-10-23
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 赤血球におけるSpectrinの糖化部位の解析と糖化防御機構の解明2009
- Author(s)
  萬野純恵、高桑雄一
- Organizer
  第82回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2009-10-21
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] The red cells have evolved an ATP-dependent protection mechanism against spectrin glycation2009
- Author(s)
  Manno S, Mohandas N, Takakuwa Y
- Organizer
  Gordon research conference
- Place of Presentation
  USA
- Year and Date
  2009-07-24
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] The Red Blood Cells Have Evolved an ATP-dependent Protective Machanism Against Spectrin Glycation2008
- Author(s)
  Sumie MANNO Yuichi TAKAKUWA
- Organizer
  European Membrane Skeleton Club (W. Mejbaum-Katzenellebogen's Molecular Biology Seminars)
- Place of Presentation
  Poland (Zakopane)
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 赤血球はATP濃度を維持することによりSpectrinの糖化を防ぐ機構を備えている2008
- Author(s)
  萬野純恵、高桑雄一
- Organizer
  第81回日本生化学会大会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] The red cells have evolved an ATP-dependent protection mechanism against spectrin glycation2008
- Author(s)
  Manno S, Takakuwa Y
- Organizer
  W. Mejbaum-Katzenellebogen's Molecular Biology Seminars
- Place of Presentation
  Zakopane
- Year and Date
  2008-06-15
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 赤血球膜機能の糖化による調節2007
- Author(s)
  萬野純恵、高桑雄一
- Organizer
  日本膜学会第29年会
- Place of Presentation
  東京
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 赤血球膜機能の糖化による調節2007
- Author(s)
  萬野純恵、高桑雄一
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 熱帯熱マラリア原虫の赤血球侵入における赤血球膜蛋白質のリン酸化の影響2007
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-12
- Data Source
  KAKENHI-PROJECT-18590408
[Presentation] スペクトリンの糖化による赤血球膜機能2007
- Author(s)
  萬野純恵、高桑雄一
- Organizer
  第80回日本生化学会大会
- Place of Presentation
  横浜
- Year and Date
  2007-12-11
- Data Source
  KAKENHI-PROJECT-19590289
[Presentation] 熱帯熱マラリア原虫の赤血球侵入における赤血球膜蛋白質のリン酸化の影響2007
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第29年会
- Place of Presentation
  東京
- Year and Date
  2007-05-10
- Data Source
  KAKENHI-PROJECT-18590408
[Presentation] Identification of a novel role for dematin in regulating red cell membrane mechanical function by PKA phosphorylation-dependent modulation of spectrin-actin interaction
- Author(s)
  Koshino, I, Mohandas, N., and Takakuwa Y
- Organizer
  Red Cell Club Annual Meeting 2011
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] Identification of the GPCR-agonist utilized by P. falciparum
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第84回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] マラリア原虫の侵入における赤血球膜骨格蛋白質デマチンの役割
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第83回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] デマチンの PKAリン酸化による赤血球膜骨格機能の調節
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第32 年会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] マラリア原虫が赤血球侵入に利用する情報伝達経路の解明
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第33 年会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] マラリア原虫の赤血球侵入に利用される GPCR アゴニストに関する検討
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第34 年会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] 脂質ラフトを舞台とした熱帯熱マラリア原虫の赤血球侵入機構とその防御
- Author(s)
  高桑雄一
- Organizer
  日本血液学会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] PKAリン酸化による赤血球膜骨格の膜への結合の変化
- Author(s)
  越野一朗、高桑雄一
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都国際会館（京都）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] lever Mechanism for malaria parasite invasion of human erythrocytes: Innocent participation of the erythrocyte raft-dependent signal transduction pathway
- Author(s)
  Koshino, I. and Takakuwa, Y.
- Organizer
  3rd Indo-Japanese Infectious Disease Symposium
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] マラリア原虫の赤血球侵入におけるATPの役割に関する検討
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第36年会
- Place of Presentation
  早稲田大学　西早稲田キャンパス（東京）
- Year and Date
  2014-05-12 – 2014-05-13
- Data Source
  KAKENHI-PROJECT-26461515
[Presentation] Regulation of erythrocyte membrane stability and malaria parasite invasion by lipid raft-dependent signal transduction
- Author(s)
  Koshino, I. and Takakuwa, Y.
- Organizer
  The 13th International Membrane Research Forum, The 6^(th) iCeMS International Symposium
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] 局所麻酔薬リドカインによる抗ウイルス効果の検討
- Author(s)
  越野一朗、高桑雄一
- Organizer
  日本膜学会第35 年会
- Data Source
  KAKENHI-PROJECT-22591112
[Presentation] Erythrocyte raft-dependent signal transduction pathway involved in Plasmodium falciparum invasion of erythrocytes
- Author(s)
  Koshino, I. and Takakuwa, Y
- Organizer
  International Union of Microbiological Societies Congress 2011
- Data Source
  KAKENHI-PROJECT-22591112

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TAKAKUWA Yuichi 高桑 雄一

高桑 雄一 タカクワ ユウイチ

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An inhibitory effect of cholesterol on expressing eat me signals in human erythrocyte membranePrincipal Investigator

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Exploration of a novel role for lidocaine as a wide range spectrum anti-infection drugPrincipal Investigator

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Effect of erythrocyte membrane lipid dynamism on malaria invasionPrincipal Investigator

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マラリア原虫の侵入を許す赤血球(宿主細胞側)の必要・十分条件の解明/予防と治療の手がかりを探るPrincipal Investigator

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マラリア原虫の侵入を許す赤血球(宿主細胞側)の必要・十分条件の解明Principal Investigator

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TAKAKUWA Yuichi 高桑雄一

高桑雄一タカクワユウイチ