OHKI Kazuo 大木和夫

Researcher Number	80115394
External Links
Affiliation (based on the past Project Information) *help	2007 – 2009: 東北大学, 大学院・理学研究科, 教授 2006: 東北大学, 大学院理学研究科, 教授 1999 – 2005: 東北大学, 大学院・理学研究科, 教授 1998: 東北大学, 大学院理学研究科, 教授 1996: Tohoku University, Professor, 大学院理学研究科, 教授 … More 1995 – 1996: Tohoku University, Graduate School of Science, Department of Physics, Professor, 大学院・理学研究科, 教授 1993 – 1996: 東北大学, 理学部, 教授 1994: 東北大学, 理学研究所, 教授 1989 – 1991: 名古屋大学, 工学部, 助教授 Less
Review Section/Research Field	Principal Investigator Biomedical engineering/Biological material science / 生物物性学 / Biophysics / Neuroscience in general Except Principal Investigator Biophysics / Biophysics/Chemical physics / Ophthalmology / 生物・生体工学 / 物性一般（含極低温･固体物性に対する理論）
Keywords	Principal Investigator 顕微鏡観察 / phospholipids / phase transition / target cell / drug delivery system / DSC / peptides / carrier liposome / membrane fusion / 医用工学 … More / 細胞 / 蛍光測定 / リポソーム / 担体リポソーム / リン脂質 / 相転移 / 標的細胞 / ドラッグディリバリシステム / 示差走査熱量測定 / ペプチド / 相体リポソーム / 膜融合 / phase separation / physical property of membrane / signal transduction / lipid-protein interaction / Structure of biomembrane / calcium ion / phosphatidic acid / inositol phospholipid / 疎水相互作用 / 静電相互作用 / 相分離 / 膜物性 / 情報伝達 / 脂質とタンパク質の相互作用 / 生体膜の構造 / カルシウムイオン / ホスファチジン酸 / イノシト-ルリン脂質 / 機能制御 / 画像解析 / ラフ / 顕微鏡画像化解析 / 実時間観察 / 膜透過性 / ラフト / 生体膜物性 / 脂質変換 / 密度測定 / 顕徼鏡画像化解析 / 非二重層形成脂質 / 温度抑制 / グリア細胞 / 海馬ニューロン / 画像化解析 / 蛍光顕微鏡観察 / 神経成長因子 / PC12細胞 / 神経回路網 / 初代培養 / 凍結保存 / 神経細胞 … More Except Principal Investigator 生体膜 / CHO細胞 / liposomes / excitotoxicity / glutamate / growth factors / neurotrophic factors / cytokines / retinal damage / ischemia / 興奮毒 / グルタミン酸 / 細胞増殖因子 / 神経栄養因子 / リポソーム / 生理活性物質 / 虚血性眼底疾患 / 虚血 / tubular assembly / spherical assembly / artificial lipid membranes / intracellular traffic of lipids / biological supramolecules / non-membrane higher ordered structure / intracellular membranes / cell organelle / 蛋白質の自己集合 / 蛋白質集合体 / 細胞運動 / 膜小胞 / 膜蛋白質 / チューブ状集合体 / 球殻状集合体 / 人工脂質膜 / 細胞内脂質輸送 / 生体超分子 / 非膜系高次構造 / 細胞内膜系 / 細胞内小器官 / selective transport / signal transmission / recognition of materials / synthetic membrane / biological membrane / 選択輸送 / 信号伝達 / 物質認識 / 合成膜 / Phosphatidylserine / Fluorescent lipid analog / Plasma membrane / CHO cell / Endocytosis / Membrane lipid asymmetry / Flippase / Flip-flop / CHO / ホスファチジルセリン / 蛍光標識脂質類似体 / 形質膜 / エンドサイトーシス / 膜の非対称性 / フリッパーゼ / フリップ-フロップ / small angle scattering / x-ray diffraction / structural analysis / supramolecule / structural formation / biomembrane / phospholipid / lipid / 生体物質 / 相転移 / 多形 / X線小角散乱 / 電子顕微鏡観察 / 小角散乱 / X線回折 / 構造解析 / 超分子 / 構造形成 / リン脂質 / 脂質 / 蛍光共鳴エネルギー移動 / ミューラ行列イメージング / ミューラ行列顕微鏡 / 膜流動性イメージング / 顕微分光 / 膜破壊性ペプチド / 可視化 / 蛍光 / 画像処理 / ラフト構造 / 強誘電性液晶素子 / 偏光顕微鏡 / ミューラー行列 / 相分離 / アポトーシス / 偏光制御 / 蛍光顕微鏡 / 時間的・空間的変動 / 生体膜の膜流動性 / 膜形成 / 糖脂質 / ニューロン / 膜融合 / 脂質輸送 / 小胞輸送 Less

Microscopic and spectroscopic study on interactions of membrane-lytic peptides with biomembranes.
- Principal Investigator
  
  OHBA Tetsuhiko
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics/Chemical physics
- Research Institution
  Tohoku University
一般化したミューラー行列顕微鏡の開発とラフト構造の動的可視化への応用
- Principal Investigator
  
  大場哲彦
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics/Chemical physics
- Research Institution
  Tohoku University
脂質膜物性の実時間顕微鏡画像解析装置による非二重層形成脂質の生体膜機能制御の研究Principal Investigator
- Principal Investigator
  
  大木和夫
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Tohoku University
細胞の膜流動性は時間的・空間的に変動しているか?
- Principal Investigator
  
  大場哲彦
- Project Period (FY)
  2000 – 2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  Tohoku University
神経回路網の形成が可能な初代培養細胞を凍結保存により随時使用する方法の確立Principal Investigator
- Principal Investigator
  
  大木和夫
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neuroscience in general
- Research Institution
  Tohoku University
Synthesis and Application of Intelligent interface System
- Principal Investigator
  
  FURUSAKI Shintaro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  生物・生体工学
- Research Institution
  The University of Tokyo
Elucidation of the organization mechanism of dynamic higher-ordered structures in biological cells
- Principal Investigator
  
  KOUYAMA Tsutomu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
Treatment of ischemic retinal injury by administration of various cytokines through vitreous cavity.
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Developmental Research for Peptides Inducing Membrane Fusion between Liposomes and CellsPrincipal Investigator
- Principal Investigator
  
  OHKI Kazuo
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Biomedical engineering/Biological material science
- Research Institution
  TOHOKU UNIVERSITY
非対称標識した脂質小胞を用いた小胞輸送経路での脂質の動態の解析
- Principal Investigator
  
  KOBAYASHI Toshihide
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
培養海馬ニューロンの膜形成における糖脂質の機能の解析
- Principal Investigator
  
  小林俊秀
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tohoku University
STUDIES ON ANIMAL CELL SURFACE PHOSPHATIDYLSERINE-FLIPPASE
- Principal Investigator
  
  KOBAYASHI Toshihide
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  TOHOKU UNIVERSITY
Supramolecular Formation in Lipids
- Principal Investigator
  
  HATTA Ichiro
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  物性一般（含極低温･固体物性に対する理論）
- Research Institution
  School of Engineering, Nagoya University
"Study on physical properties of inositol phospholipid in cellular signal transduction"Principal Investigator
- Principal Investigator
  
  OHKI Kazuo
- Project Period (FY)
  1989 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  生物物性学
- Research Institution
  Nagoya University

All 2010 2009 2008 2007 2006 2005 2004

All Journal Article Presentation Book

[Book] 現代物理学展開シリーズ8「生物物理学」2010
- Author(s)
  大木和夫、宮田英威
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-19540425
[Book] 生物物理学(現代物理学展開シリーズ8)2010
- Author(s)
  大木和夫, 他
- Publisher
  朝倉出版
- Data Source
  KAKENHI-PROJECT-19540425
[Book] 生物物理学ハンドブック(ISBN4-254-17122-6 C3045)2005
- Author(s)
  大木和夫(分担執筆)
- Publisher
  朝倉書店
- Data Source
  KAKENHI-PROJECT-14658208
[Journal Article] ミューラ行列顕微鏡によるリポソームの観察2010
- Author(s)
  大場哲彦, 江田泰明, 梅津友平, 大木和夫
- Journal Title
  
  膜 22
  
  Pages: 121-124
- Data Source
  KAKENHI-PROJECT-19540425
[Journal Article] 磁場下における脂質膜及び脂質膜-メリチン系のダイナミクスに関する研究2008
- Author(s)
  玉造広野, 大場哲彦, 大木和夫
- Journal Title
  
  膜 20
  
  Pages: 61-64
- Data Source
  KAKENHI-PROJECT-19540425
[Journal Article] 脂質膜のダイナミクスとその磁場の影響について2008
- Author(s)
  玉造広野, 大場哲彦, 佐崎元, 大木和夫
- Journal Title
  
  脂質生化学研究 50
  
  Pages: 335-337
- NAID
  10024355969
- Data Source
  KAKENHI-PROJECT-19540425
[Journal Article] Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide2006
- Author(s)
  Y.Taniguchi, T.Ohba, H.Miyata, K.Ohki
- Journal Title
  
  Biochim.Biophys.Acta (印刷中)
- Data Source
  KAKENHI-PROJECT-17654081
[Journal Article] Drug Delivery system (DDS) by use of liposomes2006
- Author(s)
  K.Ohki
- Journal Title
  
  Membrane 31
  
  Pages: 38-39
- NAID
  10017154124
- Data Source
  KAKENHI-PROJECT-17654081
[Journal Article] Rapid phase change of lipid microdomains in giant vesicles induced by conversion of sphingomyelin to ceramide2006
- Author(s)
  Y.Taniguchi, T.Ohba, H.Miyata, K.Ohki
- Journal Title
  
  Biochimica et Biophysica Acta 1758
  
  Pages: 145-153
- Data Source
  KAKENHI-PROJECT-17654081
[Journal Article] Microscopic imaging of phase separation in giant liposome by using laurdan at video rate2005
- Author(s)
  T.Ohba, S.Tsuchiya, T.Kumeta, K.Ohki
- Journal Title
  
  Jpn.J.Appl.Phys. 44
  
  Pages: 8733-8738
- NAID
  10016959796
- Data Source
  KAKENHI-PROJECT-17654081
[Journal Article] Study on Factors Inducing Heterogeneous Distribution in Biomembranes2004
- Author(s)
  A.Kodama, Y.Taniguchi, K.Ohki
- Journal Title
  
  Membrane Symposium 16
  
  Pages: 129-132
- Data Source
  KAKENHI-PROJECT-14658208
[Journal Article] 非二重層形成脂質の膜物性と生体膜機能との関連2004
- Author(s)
  大木和夫
- Journal Title
  
  生物物理 44(4)
  
  Pages: 161-166
- NAID
  110001158644
- Data Source
  KAKENHI-PROJECT-14658208
[Journal Article] PC12D細胞の突起伸長過程における膜ドメインの掲示観察:膜流動性イメージングによる研究2004
- Author(s)
  木内泰, 大場哲彦, 大木和夫
- Journal Title
  
  脂質生化学研究 46
  
  Pages: 147-150
- Data Source
  KAKENHI-PROJECT-14658208
[Presentation] ミューラ行列顕微鏡によるリポソームの観察2010
- Author(s)
  江田泰明, 梅津友平, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第48回年会
- Place of Presentation
  仙台市
- Year and Date
  2010-09-22
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Relationship between biological functions and physical properties of membrane inferred by microscopic imaging2009
- Author(s)
  谷口幸範, 田中拓、武藤健一、木内泰、大場哲彦, 大木和夫
- Organizer
  The 6^<th> Asian Biophysical Association Symposium
- Place of Presentation
  香港、中国
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Direct microscopic observation of biomembrane dynamics under a static magnetic field.2009
- Author(s)
  玉造広野, 大場哲彦, 佐崎元, 大木和夫
- Organizer
  The 6^<th> Asian Biophysical Association Symposium
- Place of Presentation
  香港、中国
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Molecular structure of sterols determines phase separation in model membranes2009
- Author(s)
  Wu Li, 大場哲彦, 大木和夫
- Organizer
  The 6^<th> Asian Biophysical Association Symposium
- Place of Presentation
  香港、中国
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Physical Properties of Amphotericin B-containing Liposomes2009
- Author(s)
  Wu Li, 大木和夫, 大場哲彦
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  アスティとくしま
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] 示差走査熱量測定及び蛍光分光測定によるメリチンと脂質膜の相互作用の研究2009
- Author(s)
  児玉篤治, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  徳島市
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Comparison of membrane physical property changes between PC membranes and PE membranes induced by melittin2009
- Author(s)
  児玉篤治, 大場哲彦, 大木和夫
- Organizer
  The 6^<th> Asian Biophysical Association Symposium
- Place of Presentation
  香港、中国
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Physical Properties of Amphotericin B-containing Liposomes2009
- Author(s)
  Wu Li, 大木和夫, 大場哲彦
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  徳島市
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] 静磁場下における人工脂質膜のダイナミックスの顕微鏡観察(2)2009
- Author(s)
  玉造広野, 大場哲彦, 佐崎元, 大木和夫
- Organizer
  日本生物物理学会第47回年会
- Place of Presentation
  徳島市
- Year and Date
  2009-10-31
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Construction of Mueller Matrix imaging2009
- Author(s)
  江田泰明, 大場哲彦, 大木和夫
- Organizer
  The 6^<th> Asian Biophysical Association Symposium
- Place of Presentation
  香港、中国
- Year and Date
  2009-01-12
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] DMPC膜及びDMPC/DHPC二成分系へのランタノイドイオンEu^<3+>の効果について2008
- Author(s)
  玉造広野, 大場哲彦, 佐崎元, 大木和夫
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡市
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] NaClがDMPGの主転移に及ぼす影響2008
- Author(s)
  児玉篤治, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡市
- Year and Date
  2008-12-03
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] ミューラ行列イメージングの構築(2)2008
- Author(s)
  江田泰明, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第46回年会
- Place of Presentation
  福岡市
- Year and Date
  2008-12-04
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Structure-dependent Effects of Steroils on Membrane Phase Behaviors2007
- Author(s)
  Wu Li, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-22
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] Structure-dependent Effects of Steroils on Membrane Phase Behaviors2007
- Author(s)
  Wu Li, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜市
- Year and Date
  2007-12-22
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] ミューラ行列イメージングの構築2007
- Author(s)
  松元峻士, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-23
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] 静磁場下における人工脂質膜のダイナミックスの顕微鏡観察2007
- Author(s)
  玉造広野, 大場哲彦, 佐崎元, 大木和夫
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  横浜市
- Year and Date
  2007-12-22
- Data Source
  KAKENHI-PROJECT-19540425
[Presentation] メリチンが誘導するPC膜とPE膜の膜物性変化の比較2007
- Author(s)
  児玉篤治, 大場哲彦, 大木和夫
- Organizer
  日本生物物理学会第45回年会
- Place of Presentation
  パシフィコ横浜
- Year and Date
  2007-12-22
- Data Source
  KAKENHI-PROJECT-19540425

1. OHBA Tetsuhiko (10250664)

# of Collaborated Projects: 6 results

# of Collaborated Products: 25 results
2. KOBAYASHI Toshihide (60162004)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. 松岡審爾 (90190420)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. HATTA Ichiro (70016070)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. TAKAHASHI Hiroshi (80236314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. FURUSAKI Shintaro (40011209)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. NAKAO Shin-ichi (00155665)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. OHYA Haruhiko (40017950)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. INUI Kenichi (70034030)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. TAKAKUWA Yuichi (40113740)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KOUYAMA Tsutomu (30170210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KASAI Michio (40022595)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SAKO Yasushi (20215700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. MIYAMOTO Shigeaki (40219811)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. ARISAKA Fumio (80133768)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. TAMAI Makoto (90004720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. TAKEDA Atushi (70261534)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. ISHIGURO Sei-ichi (20111271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 宮田英威 (90229865)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 長野宏美 (80281963)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 加藤知 (70177442)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 宮嶋孝一郎 (30025689)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 野澤義則 (10021362)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 石渡信一 (10130866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 神谷律 (10124314)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 中西守 (90090472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

OHKI Kazuo 大木 和夫

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脂質膜物性の実時間顕微鏡画像解析装置による非二重層形成脂質の生体膜機能制御の研究Principal Investigator

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神経回路網の形成が可能な初代培養細胞を凍結保存により随時使用する方法の確立Principal Investigator

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Developmental Research for Peptides Inducing Membrane Fusion between Liposomes and CellsPrincipal Investigator

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"Study on physical properties of inositol phospholipid in cellular signal transduction"Principal Investigator

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[Book] 現代物理学展開シリーズ8「生物物理学」2010

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OHKI Kazuo 大木和夫