Toyoshima Chikashi 豊島近

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TOYOSHIMA Chikashi 豊島近

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Researcher Number	70172210
Other IDs
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Affiliation (Current)	2023: 東京大学, 定量生命科学研究所, 特任教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 東京大学, 定量生命科学研究所, 特任教授 2017 – 2019: 東京大学, 定量生命科学研究所, 教授 1994 – 2016: The University of Tokyo, Institute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授 1995: 東京大学, 分子細胞生物研究所, 教授 1991 – 1993: 東京工業大学, 生命理工学部, 助教授 1990: 東京工業部学, 理学部, 助教授
Review Section/Research Field	Principal Investigator Biophysics / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields / Biological Sciences / 生物物性学 / Biophysics / Basic Section 43040:Biophysics-related Except Principal Investigator Biophysics / 生物物性学 / Medium-sized Section 49:Pathology, infection/immunology, and related fields / Basic Section 49010:Pathological biochemistry-related … More / Biological Sciences / 医薬分子機能学 / Neuroscience in general / Biophysics Less
Keywords	Principal Investigator 膜蛋白質 / イオンポンプ / 結晶解析 / ATPase / 能動輸送 / 蛋白質結晶 / 構造解析 / X線結晶解析 / ion pump / membrane proteins … More / 三次元構造 / 低温電子顕微鏡法 / 三次元構造解析 / 構造生物学 / active transport / 電子顕微鏡 / 氷包埋法 / X-ray crystallography / electron crystallography / カルシウムポンプ / protein crystal / three-dimensional structure / 電子線結晶解析 / 筋小胞体 / structural analysis / Protein crystals / 電子線回折 / sarcoplasmic reticulum / cryo-electron microscopy / エネルギー変換 / 生物物理 / 脂質二重膜 / 画像解析 / 二次元結晶 / カルシウムATPase / 立体障害 / 反応中間体 / ナトリウムポンプ / 結晶大型化 / 結晶 / 蛋白質 / data collection / cryo holder / cryo electron microscopy / structure analysis / crystallography / electron diffraction / データ収集 / 低温試料ホルダー / クライオ電子顕微鏡 / over expression / 大量発現 / electron microscopy / calcium pump / Membrane proteins / Structural study / Electron microscopy / Ion channel / Acetylcholine receptor / イオンチャンネル / アセチルコリン受容体 / Cryo-transfer / Radiation damage / Structural analysis / Ice embedding / Electron diffraction / Electron microscope / 電子線 / CCDカメラ / 低電子線量法 / 電子線回析 / クライオトランスファー / 電子線損傷 / membrance proteins / three-dimensional structural / calcium / 構造変化 / カルシウム / time-resolved / caged compounds / ice embedding / flash photolysis / 急速凍結法 / 氷胞埋法 / 時間分解 / caged物質 / 閃光光分解 / エネルギー交換 / X線結晶 / チトクロムbc1複合体 / チトクロム酸化酵素 / 呼吸鎖酵素 / 電子伝達系 / チトクローム酸化酵素 … More Except Principal Investigator 超分子複合体 / 構造生物学 / 膜蛋白質 / 二次元結晶 / Naチャンネル / エナンチオマー / ジヒドロピリジン化合物 / L型Caチャンネル / アルツハイマー病 / 異常凝集体 / 神経細胞死 / 神経変性疾患 / TRNOE / シンクロトロン放射光 / 高次構造 / X線結晶構造解析 / 膜タンパク質 / 結晶構造解析 / クローニング / イオンチャネル / 光学分割 / 電子顕微鏡 / 生体膜 / 電子線構造解析 / 治療法 / コンパニオン診断薬 / ペプチド創薬 / タンパク質ータンパク質相互作用 / ナトリウムポンプ / 診断方法 / membrane proteins / Group of biomacromolecules / Complex of biomacromolecules / X-ray crystallography / Structural biology / Synchrotron radiation / Biological machineries / 蛋白結晶学 / X線結晶学 / 生体高分子集合系 / 生体高分子複合体 / 生物マシーナリー / drug design / new compounds / structural biology / drug binding site / photoaffinity labeling / Calcium antagonist / 薬理活性 / 抗ペプチド抗体 / 精密合成化学 / 心筋Caチャンネル / 光アフィニティラベリング / ドラッグデザイン / 新規化合物 / 薬物結合部位 / 光アフィニティラベリング / Ca拮抗薬 / tubular assembly / spherical assembly / artificial lipid membranes / intracellular traffic of lipids / biological supramolecules / non-membrane higher ordered structure / intracellular membranes / cell organelle / 蛋白質の自己集合 / 蛋白質集合体 / 細胞運動 / 膜小胞 / チューブ状集合体 / 球殻状集合体 / 人工脂質膜 / 細胞内脂質輸送 / 生体超分子 / 非膜系高次構造 / 細胞内膜系 / 細胞内小器官 / Muscarine / Acetylcholine / G Protein / Transmitter / Large-Scale Purification / Conformation / Receptor / 伝達物質 / レセプター / ムスカリン / アセチルコリン / Gタンパク質 / 神経伝達物質 / 大量発現 / 受容体 / Synchrotron Radiation / Supramacromolecular Complex / X-ray Structure Analysis / Structural Biology / Protein Crystallography / シンクロトロン放射学 / シンクロトン放射光 / X線構造解析 / タンパク質結晶学 / Cryo-electron microscopy / Molecular biology / Patch clamp / Model channel / Dynamical structure / Higher order structure / Ion channels / 合成チャネル / 電気生理学 / チャネル蛋白質 / 動的構造機能連関 / 分子動力学 / クライオ電顕 / 分子生物学 / パッチクランプ / モデルチャネル / 動的構造 / Three dimensional-stractural prediction / Crystallization / Crystal growth mechanism / Folding mechanism / Electron micrographic analysis / X-ray crystallographic analysis / Supermolecular complex / Membrane protein / チトクロムbc_1複合体 / チトクロム酸化酵素 / タンパク質立体構造形成機構 / タンパク質立体構造予測 / 結晶成長機構 / 結晶化 / カタラーゼ / Ca2+-ATPase / 構造・機能相関 / カルシウムポンプ / トランスポータ / 水チャネル / トリチウム標識 / 発現プロモーター / 融合遺伝子 / 転移ベクター / 翻訳開始部位 / メタノール資化性菌 / 大量生産 / NMDAレセプター / バキュロウイルス / 電子線回折 / プロトン輸送 / バクテリオロドプシン / 蛋白質の結晶化 Less

イオンポンプ蛋白質作動機構の構造的理解の完成とその高次機能の構造生物学への発展Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 43040:Biophysics-related
- Research Institution
  The University of Tokyo
Development of artificial reaction intermediates by introduction of steric hindrancePrincipal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 49:Pathology, infection/immunology, and related fields
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Developement of technology for visualising lipid bilayers in crystals of membrane proteinsPrincipal Investigator
- Principal Investigator
  
  Toyoshima Chikashi
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
異常凝集体に対する体外診断法開発によるアルツハイマー病の早期診断と病態解明
- Principal Investigator
  
  星美奈子
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe
Structural biology of active transport and its regulation by P-type ATPasesPrincipal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  The University of Tokyo
Structural elucidation of active transport by P-type ATPasesPrincipal Investigator
- Principal Investigator
  
  Toyoshima Chikashi
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Visualization of Coulomb potential by electron crystallography
- Principal Investigator
  
  YONEKURA Koji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Biophysics
- Research Institution
  The Institute of Physical and Chemical Research
Structural biology of membrane transporters with a view to drug developmentPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  2011 – 2016
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Structural biology of ion transportersPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Specially Promoted Research
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
薬剤開発を視野に入れたイオンポンプの構造研究Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2007 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
P型イオンポンプによる能動輪送機構の構造的解明Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  The University of Tokyo
Ca-ATPaseの電子線・X線結晶解析Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  1999 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
Crystallographics study of active ion transportPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Structural elucidation of active ion transportPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Structural Biology of Biological Machineries through X-ray Protein Crystallography Reinforced by Synchrotron Radiation
- Principal Investigator
  
  TANOKURA Masaru, 三井幸雄
- Project Period (FY)
  1998 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  The University of Tokyo
  Nagaoka University of Technology
Development of electron diffraction methods for protein crystallographyPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Crystallographic study of calcium ion pump of sarcoplasmic reticulumPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
イオンチャンネル機能を実現する超分子構造の化学的,物理学的解析
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
Structural Basis of Active Transport by Ion PumpsPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
イオンチャンネル機能を実現する超分子構造の化学的、物理学的解析
- Principal Investigator
  
  中山仁
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
チャネルとトランスポータの構造・機能相関
- Principal Investigator
  
  岡田泰伸
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Okazaki National Research Institutes
Elucidation of the organization mechanism of dynamic higher-ordered structures in biological cells
- Principal Investigator
  
  KOUYAMA Tsutomu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
化学的,物理学的手法によるイオンチャンネル超分子構造の解析
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kumamoto University
NMDAレセプターの大量生産とその三次元構造解析
- Principal Investigator
  
  山根和彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Gating mechanism of the acetylcholine receptor ion channelPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  The University of Tokyo
New Generation of Protein Crystallography
- Principal Investigator
  
  MIKI Kunio
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Biophysics
- Research Institution
  KYOTO UNIVERSITY
Conformation of the Muscarinic Acetylcholine Receptor
- Principal Investigator
  
  HAGA Tatsuya
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neuroscience in general
- Research Institution
  University of Tokyo
低温電子顕微鏡法による呼吸鎖酵素複合体二次元結晶の三次元構造解析Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
PIONEERING RESEARCH ON THE DYNAMICAL ASPECT OF STRUCTURE-FUNTION RELATIONSHIP IN ION CHANNELS
- Principal Investigator
  
  SOKABE Masahiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Nagoya University
Development of technologise for three-dimensional structural analysis of protein crystals using electron microscopePrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  The University of Tokyo
  Tokyo Institute of Technology
低温電子顕微鏡による呼吸鎖酵素複合合体二次元結晶の三次元構造解析Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Institute of Technology
Three-dimensional strutural study of the sarcoplasmic reticulum clcium ATPase under various physiological conditions.Principal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  生物物性学
- Research Institution
  Tokyo Institute of Technology
氷包埋低温電子顕微鏡によるカルシウムATPaseの三次元構造解析Principal Investigator
- Principal Investigator
  
  豊島近
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  生物物性学
- Research Institution
  Tokyo Institute of Technology
Time-resolved 3-dimensional Structural Study of Biological Reactions by Flash Photolysis and Frozen-hydrated Electron MicroscopyPrincipal Investigator
- Principal Investigator
  
  TOYOSHIMA Chikashi
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  生物物性学
- Research Institution
  Tokyo Institute of Technology
膜蛋白質3次元微結晶の電子線構造解析
- Principal Investigator
  
  KOUYAMA Tsutomu
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  生物物性学
- Research Institution
  The Institute of Physical and Chemical Research
Folding and crystallization conditions of menbrane protein supercomplexes
- Principal Investigator
  
  YOSHIKAWA Shinya
- Project Period (FY)
  1990 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  生物物性学
- Research Institution
  Himeji Institute of Technology

[Journal Article] Cryoelectron microscopy of Na+,K+-ATPase in the two E2P states with and without cardiotonic steroids.2022
- Author(s)
  Ryuta Kanai , Flemming Corneliusb , Bente Vilsenb , Chikashi Toyoshima
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 119 Issue: 15
- DOI
  10.1073/pnas.2123226119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20376
[Journal Article] Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state2020
- Author(s)
  Kanai Ryuta、Cornelius Flemming、Ogawa Haruo、Motoyama Kanna、Vilsen Bente、Toyoshima Chikashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 118 Issue: 1 Pages: 1-12
- DOI
  10.1073/pnas.2020438118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-20K20376, KAKENHI-PROJECT-19H00975
[Journal Article] What ATP binding does to the Ca2+ pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2+2020
- Author(s)
  Kabashima Yoshiki、Ogawa Haruo、Nakajima Rie、Toyoshima Chikashi
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 117 Issue: 31 Pages: 18448-18458
- DOI
  10.1073/pnas.2006027117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20376, KAKENHI-PROJECT-19H00975
[Journal Article] X線コントラスト変調法によって明らかになった膜蛋白質と燐脂質の相互作用のダイナミクス2018
- Author(s)
  豊島　近、乗松　良行
- Journal Title
  
  放射光
  
  Volume: 31 Pages: 212-218
- NAID
  40021599683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02499
[Journal Article] Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA2018
- Author(s)
  Xu Xingya、Kanai Ryuta、Nakazawa Norihiko、Wang Li、Toyoshima Chikashi、Yanagida Mitsuhiro
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 21
- DOI
  10.1073/pnas.1803564115
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-16H02499, KAKENHI-PROJECT-16K18500
[Journal Article] X線コントラスト変調法によって明らかになった膜蛋白質と燐脂質の相互作用のダイナミクス2018
- Author(s)
  豊島　近、乗松　良行
- Journal Title
  
  放射光
  
  Volume: 31 Pages: 212-218
- NAID
  40021599683
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K20376
[Journal Article] Mechanism of the E2 to E1 transition in Ca2+ pump revealed by crystal structures of gating residue mutants.2018
- Author(s)
  Naoki Tsunekawa, Haruo Ogawa, Junko Tsueda, Toshihiko Akiba, and Chikashi Toyoshima
- Journal Title
  
  Proceedings of the National Academy of Sciences
  
  Volume: 115 Issue: 50 Pages: 12722-12727
- DOI
  10.1073/pnas.1815472115
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02499
[Journal Article] Distinct pH dependencies of Na+/K+selectivity at the two faces of Na,K-ATPase2017
- Author(s)
  Cornelius Flemming、Tsunekawa Naoki、Toyoshima Chikashi
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 293 Issue: 6 Pages: 2195-2205
- DOI
  10.1074/jbc.ra117.000700
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Journal Article] Protein-lipid interplay revealed with crystals of a Calcium pump2017
- Author(s)
  Norimatsu, Y and Toyoshima, C
- Journal Title
  
  Nature
  
  Volume: 545 Issue: 7653 Pages: 193-198
- DOI
  10.1038/nature22357
- Description
  掲載確定
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-16H02499
[Journal Article] The road to understanding an ion pump2016
- Author(s)
  Toyoshima, C
- Journal Title
  
  PHYSICA SCRIPTA
  
  Volume: 91 Issue: 4 Pages: 042501-042501
- DOI
  10.1088/0031-8949/91/4/042501
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-16H02499
[Journal Article] Mn^<2+> transport by Ca^<2+>-ATPase of sarcoplasmic reticulum2016
- Author(s)
  Yonekura, SI and Toyoshima, C
- Journal Title
  
  FEBS Letters
  
  Volume: 590 Issue: 14 Pages: 2086-2095
- DOI
  10.1002/1873-3468.12244
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-16H02499
[Journal Article] Stimulation, inhibition or stabilization of Na, K-ATPase caused by specific lipid interactions at distinct sites2015
- Author(s)
  M. Habeck, H. Haviv, A. Katz, E. Kapri-Pardes, S. Ayciriex, A. Shevchenko, H. Ogawa, C. Toyoshima, and S.J.D. Karlish
- Journal Title
  
  J. Biol. Chem.
  
  Volume: 290 Issue: 8 Pages: 4829-4842
- DOI
  10.1074/jbc.m114.611384
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012
[Journal Article] Biselyngbyasides, Cytotoxic Marine Macrolides, are Novel and Potent Inhibitors of the Ca2+ Pumps with a Unique Mode of Binding2015
- Author(s)
  Morita, M., Ogawa, H., Ohno, O., Yamori, T., Suenaga, K., Toyoshima, C.
- Journal Title
  
  FEBS Lett.
  
  Volume: 589 Issue: 13 Pages: 1406-1411
- DOI
  10.1016/j.febslet.2015.04.056
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-23000014
[Journal Article] Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type 1 muscle2015
- Author(s)
  Zhao, Y., Ogawa, H., Yonekura, S., Mitsuhashi, H., Mitsuhashi, S., Nishino, I., Toyoshima, C., Ishiura, S.
- Journal Title
  
  Biochim. Biophys. Acta.
  
  Volume: 1852 Issue: 10 Pages: 2042-2047
- DOI
  10.1016/j.bbadis.2015.07.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-23000014
[Journal Article] Sequential substitution of K+ bound to Na+,K+-ATPase visualized by X-ray crystallography2015
- Author(s)
  Ogawa, H., Cornelius, F., Hirata, A., Toyoshima, C.
- Journal Title
  
  Nat Commun.
  
  Volume: 6 Issue: 1 Pages: 8004-8004
- DOI
  10.1038/ncomms9004
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-23000014
[Journal Article] Electron crystallography of ultrathin 3D protein crystals : Atomic models with charges2015
- Author(s)
  K. Yonekura, K. Kato, M. Ogasawara, M. Tomita and C. Toyoshima
- Journal Title
  
  Proc. Nat. Acad. Sci. USA
  
  Volume: 112 Issue: 11 Pages: 3368-3373
- DOI
  10.1073/pnas.1500724112
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-24657111
[Journal Article] General and specific lipid-protein interactions in Na, K-ATPase2015
- Author(s)
  F. Cornelius, M. Habeck, R. Kanai, C. Toyoshima and S. J. D. Karlish
- Journal Title
  
  Biochimica et Biophysica Acta-Biomembranes
  
  Volume: 1848 Issue: 9 Pages: 1729-1743
- DOI
  10.1016/j.bbamem.2015.03.012
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23000014
[Journal Article] Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca^<2+>pumps with a unique mode of binding2015
- Author(s)
  M. Morita, H. Ogawa, 0. Ohno, T. Yamori, K. Suenaga, C. Toyoshima
- Journal Title
  
  FEBS Letters
- Description
  【掲載確定】印刷中
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014
[Journal Article] ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding2014
- Author(s)
  Y. Akai, R. Kanai, N. Nakazawa, M. Ebe, C. Toyoshima and M. Yanagida
- Journal Title
  
  Open Biol.
  
  Volume: 4 Issue: 12 Pages: 140193-140193
- DOI
  10.1098/rsob.140193
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-25840013
[Journal Article] Crystal structures of the calcium pump and sarcolipin in the E1·Mg2+ state.2013
- Author(s)
  C. Toyoshima
- Journal Title
  
  Nature
  
  Volume: 495 Issue: 7440 Pages: 260-264
- DOI
  10.1038/nature11899
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-25650020
[Journal Article] New crystal structures of PII-type ATPases : Excitement continues.2013
- Author(s)
  C. Toyoshima and F. Cornelius
- Journal Title
  
  Curr. Opinion Struct. Biol.
  
  Volume: 23 Issue: 4 Pages: 507-514
- DOI
  10.1016/j.sbi.2013.06.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014
[Journal Article] Crystal structure of a Na^+-bound Na^+, K^+-ATPase preceding the E1P state.2013
- Author(s)
  R. Kanai, H. Ogawa, B. Vilsen, F. Cornelius and C. Toyoshima
- Journal Title
  
  Nature
  
  Volume: 502 Issue: 7470 Pages: 201-206
- DOI
  10.1038/nature12578
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-25650020
[Journal Article] First crystal structures of Na^+, K^+-ATPase : New light on the oldest ion pump2011
- Author(s)
  C.Toyoshima, et al.
- Journal Title
  
  Structure
  
  Volume: 19 Issue: 12 Pages: 1732-1738
- DOI
  10.1016/j.str.2011.10.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23000014
[Journal Article] Trinitrophenyl-derivatives bind differently from parent adenine nucleotides to Ca^<2+>-ATPase in the absence of Ca^<2+>2011
- Author(s)
  C.Toyoshima
- Journal Title
  
  Proc.Nat.Acad.Sci.USA.
  
  Volume: 108 Pages: 1833-1838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca^<2+>-ATPase in the absence of Ca^<2+>2011
- Author(s)
  C. Toyoshima, S. Yonekura, J. Tsueda and S. Iwasawa
- Journal Title
  
  Proc. Nat. Acad. Sci. USA
  
  Volume: 108 Pages: 1833-1838
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Cornelius : First crystal structures of Na+, K^+-ATPase : New light on the oldestion pump2011
- Author(s)
  C. Toyoshima, R. Kanai and F
- Journal Title
  
  Structure
  
  Volume: 19 Pages: 1732-1738
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] イオンポンプ(P型ATPase)の構造生物学2011
- Author(s)
  豊島近
- Journal Title
  
  放射光
  
  Volume: 24 Pages: 2-9
- NAID
  10027411840
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase.2009
- Author(s)
  T. Tsuda, C. Toyoshima
- Journal Title
  
  EMBO J. 28
  
  Pages: 1782-1791
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase2009
- Author(s)
  T. Tsuda and C. Toyoshima
- Journal Title
  
  EMBO J
  
  Volume: 28 Pages: 1782-1791
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Crystal tructure of the sodium-potassium pump (Na+, K+-ATPase)with bound potassium and ouabain.2009
- Author(s)
  H. Ogawa, T. Shinoda, F. Cornelius, C. Toyoshima
- Journal Title
  
  Proc. Nat. Acad. Sci. USA 106
  
  Pages: 13742-13747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] How Ca^<2+>-ATPase pumps ions across the sarcoplasmic reticulum membrane2009
- Author(s)
  C.Toyoshima
- Journal Title
  
  Biochem.Biophys.Acta 1793
  
  Pages: 941-946
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Crystal structure of the sodium-potassium pump at 2. 4 A resolution2009
- Author(s)
  T. Shinoda, H. Ogawa, F. Cornelius and C. Toyoshima
- Journal Title
  
  Nature
  
  Volume: 459 Pages: 446-450
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Crystal structure of the sodium-potassium pump at 2. 4 A resolution.2009
- Author(s)
  T. Shinoda, H. Ogawa, F. Cornelius, C. Toyoshima
- Journal Title
  
  Nature 459
  
  Pages: 446-450
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Crystal structure of thesodium-potassium pump(Na^+, K^+-ATPase) withbound potassium and ouabain2009
- Author(s)
  H. Ogawa, T. Shinoda, F. Cornelius and C. Toyoshima
- Journal Title
  
  Proc. Nat. Acad. Sci. USA
  
  Volume: 106 Pages: 13742-13747
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Structural aspects of ion pumping by Ca^<2+>-ATPase of sarcoplasmic reticulum2008
- Author(s)
  C. Toyoshima
- Journal Title
  
  Arch. Biochem. Biophys 476
  
  Pages: 3-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum.2008
- Author(s)
  C. Toyoshima
- Journal Title
  
  Arch. Biochem. Biophys. 476
  
  Pages: 3-11
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Conformationalfluctuations of the Ca^<2+>-ATPase in thenative membrane environment2008
- Author(s)
  G. Inesi, D. Lewis, C. Toyoshima, A. Hirata and L. de Meis
- Journal Title
  
  J. Biol. Chem
  
  Volume: 283 Pages: 1189-1196
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] How processing ofaspartylphosphate is coupled to lumenalgating of the ion pathway in the calciumpump2007
- Author(s)
  C. Toyoshima, Y. Norimatsu, S. Iwasawa, T. Tsuda and H. Ogawa
- Journal Title
  
  Proc. Nat. Acad. Sci.
  
  Volume: 104 Pages: 19831-19836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump2007
- Author(s)
  C. Toyoshima
- Journal Title
  
  Proc. Nat. Acad. Sci. USA. 104
  
  Pages: 19831-19836
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Domain organization and movements in heavy metal ion pumps : Papain digestion of CopA, a Cu^+-transporting ATPase2007
- Author(s)
  Y. Hatori, E. Majima, T. Tsuda and C. Toyoshima
- Journal Title
  
  J. Biol. Chem
  
  Volume: 282 Pages: 25213-25221
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Interdomain communication incalcium pump as revealed in the crystalstructures with transmembrane inhibitors2007
- Author(s)
  M. Takahashi, Y. Kondou and C. Toyoshima
- Journal Title
  
  Proc. Nat. Acad. Sci.
  
  Volume: 104 Pages: 5800-5805
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump.2007
- Author(s)
  C. Toyoshima, Y. Norimatsu, S. Iwasawa, T. Tsuda, H. Ogawa
- Journal Title
  
  Proc. Nat. Acad. Sci. USA. 104
  
  Pages: 19831-19836
- Data Source
  KAKENHI-PROJECT-19002013
[Journal Article] Structural basis of ion pumping by Ca^<2+> -ATPase of the sarcoplasmic reticulum2004
- Author(s)
  C.Toyoshima
- Journal Title
  
  Ann.Rev.Biochem. 73
  
  Pages: 269-92
- Data Source
  KAKENHI-PROJECT-14GS0308
[Journal Article] Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues.2004
- Author(s)
  C.Toyoshima
- Journal Title
  
  Nature 432
  
  Pages: 361-368
- Data Source
  KAKENHI-PROJECT-14GS0308
[Journal Article] Crystal structure of the calcium pump wlth a bound ATP analogue.2004
- Author(s)
  C.Toyoshima
- Journal Title
  
  Nature 430
  
  Pages: 529-535
- Data Source
  KAKENHI-PROJECT-14GS0308
[Presentation] What is the activation signal for phosphoryl transfer in the calcium2019
- Author(s)
  豊島　近
- Organizer
  Honorary Skou Professor Seminar,Aarhus University, Aarhus, Denmark
- Invited
- Data Source
  KAKENHI-PROJECT-19H00975
[Presentation] P 型 ATPase によるイオン輸送とその制御機構2019
- Author(s)
  豊島　近
- Organizer
  日本薬学会　第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] イオンポンプの構造生物学：脂質二重膜からプロトンまで2019
- Author(s)
  豊島　近
- Organizer
  2019年度iBIX-JAXA-KEK物構研-QST合同研究会「クライオEM、X線、中性子タンパク質構造解析の住み分け」
- Invited
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] イオンポンプの構造生物学：脂質二重膜からプロトンまで2019
- Author(s)
  豊島　近
- Organizer
  2019年度iBIX-JAXA-KEK物構研-QST合同研究会「クライオEM、X線、中性子タンパク質構造解析の住み分け」
- Data Source
  KAKENHI-PROJECT-19H00975
[Presentation] What is the activation signal for phosphoryl transfer in the calcium2019
- Author(s)
  豊島　近
- Organizer
  Honorary Skou Professor Seminar,Aarhus University, Aarhus, Denmark
- Invited
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] P 型 ATPase によるイオン輸送とその制御機構2019
- Author(s)
  豊島　近
- Organizer
  日本薬学会　第139年会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Structural Biology of Ion Pumps2018
- Author(s)
  豊島　近
- Organizer
  Post Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] Role of phospholipids in ion pumping2018
- Author(s)
  豊島　近
- Organizer
  5th ShanghaiTech-SIAIS BioForum
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] Structural Biology of Ion Pumps2018
- Author(s)
  豊島　近
- Organizer
  The 2nd International Symposium on Chemical Communication
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] イオンポンプの構造生物学：膜の可視化から量子化学計算まで2018
- Author(s)
  豊島　近
- Organizer
  生理研プロジェクト「機能タンパク質の構造と機能のダイナミクスと、それに基づく細胞・生体システム作動機構の研究拠点の形成」平成29年度成果報告会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] 原子構造に基づく筋小胞体カルシウムポンプの制御機構2018
- Author(s)
  豊島　近
- Organizer
  日本筋学会第4会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] カルシウムポンプの結晶構造解析の現状2018
- Author(s)
  豊島　近
- Organizer
  第2回SPring-8における蛋白質構造生物学研究の現状と将来
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Structural Biology of the Calcium Pump2018
- Author(s)
  豊島　近
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] Structural Biology of the Calcium Pump2018
- Author(s)
  豊島　近
- Organizer
  第18回国際薬理学・臨床薬理学会議
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] カルシウムポンプの結晶構造解析の現状2018
- Author(s)
  豊島　近
- Organizer
  第2回SPring-8における蛋白質構造生物学研究の現状と将来
- Invited
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] Role of phospholipids in ion pumping2018
- Author(s)
  豊島　近
- Organizer
  5th ShanghaiTech-SIAIS BioForum
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] 原子構造に基づく筋小胞体カルシウムポンプの制御機構2018
- Author(s)
  豊島　近
- Organizer
  日本筋学会第4会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-20K20376
[Presentation] Structural Biology of Ion Pumps2018
- Author(s)
  豊島　近
- Organizer
  The 2nd International Symposium on Chemical Communication
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Structural Biology of Ion Pumps2018
- Author(s)
  豊島　近
- Organizer
  Post Symposium
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Crystal structure analysis of Ca2+- and Na+,K+-ATPases2017
- Author(s)
  豊島　近
- Organizer
  The 15th International Conference on Na,K-ATPase and Related Transport ATPases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] カルシウムポンプの構造生物学 - 燐脂質との相互作用2017
- Author(s)
  豊島近
- Organizer
  第2回生物構造学研究会
- Place of Presentation
  研究社英語センター大会議室(東京都新宿区)
- Year and Date
  2017-03-29
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Protein-Lipid Interplay as Revealed by X-ray Solvent Contrast Modulation with the crystals of Ca^<2+>-ATPases in four different States2017
- Author(s)
  豊島近
- Organizer
  IGER International Symposium on Physics of Life
- Place of Presentation
  名古屋大学(愛知県名古屋市)
- Year and Date
  2017-03-26
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Crystal structure analysis of Ca2+- and Na+,K+-ATPases” The 15th International Conference on Na,K-ATPase and Related Transport ATPases2017
- Author(s)
  豊島　近
- Organizer
  The 15th International Conference on Na,K-ATPase and Related Transport ATPases
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Protein-lipid interplay revealed by X-ray solvent contrast modulation with calcium pump crystals2017
- Author(s)
  豊島　近
- Organizer
  19th IUPAB and 11th EBSA congress
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] イオンポンプの構造的理解の長い道2017
- Author(s)
  豊島　近
- Organizer
  第35回先端医療センター Monthly Lecture
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Structural biology of Na+,K+-ATPase: towards understanding of mutations in ATP1A32017
- Author(s)
  豊島　近
- Organizer
  第6回ATP1A3遺伝子関連疾患国際シンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Protein-Lipid Interplay as Revealed by X-ray Solvent Contrast Modulation with the crystals of Ca2+-ATPases in four different States2017
- Author(s)
  豊島　近
- Organizer
  IGER International Symposium on Physics of Life
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] カルシウムポンプの構造生物学 - 燐脂質との相互作用2017
- Author(s)
  豊島　近
- Organizer
  第2回生物構造学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Structural Basis of Ion Pumping by Ca2+-ATPase2017
- Author(s)
  豊島　近
- Organizer
  第20回カルシウム結合蛋白質とカルシウム機構の生理と病態に関する国際シンポジウム(CaBP20)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02499
[Presentation] Large-scale production of mammalian membrane proteins toward determination of high resolution structures2017
- Author(s)
  Haruo Ogawa, Chikashi Toyoshima
- Organizer
  Biophysical Society 61st Annual Meeting
- Place of Presentation
  Ernest N. Morial Convention Center(米国ニューオーリンズ)
- Year and Date
  2017-02-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Stuructural biology of P-type ion translocating ATPases : towards complete understanding of the mechanism2016
- Author(s)
  C. Toyoshima
- Organizer
  Aminoff Prize Symposium2016
- Place of Presentation
  University of Gothenburg (Gothenburg, Sweden)
- Year and Date
  2016-03-30
- Description
  【発行確定】
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] 高分解能構造解析へ向けた哺乳類由来膜蛋白質の大量生産2016
- Author(s)
  小川治夫、村山尚、呉林なごみ、豊島近
- Organizer
  第89回日本生化学会大会シンポジウム
- Place of Presentation
  仙台国際センター(宮城県仙台市)
- Year and Date
  2016-09-26
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Ca2+-ポンプ構造研究の最前線2016
- Author(s)
  小川治夫、椛島佳樹、豊島近
- Organizer
  日本生体エネルギー研究会第42回討論会
- Place of Presentation
  名古屋工業大学4号館ホール(愛知県名古屋市)
- Year and Date
  2016-12-20
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Kinetics by X-ray crystallography : sequential substitution of K^+ bound to Na^+, K^+-ATPase2015
- Author(s)
  H. Ogawa, A. Hirata, F. Cornelius, C. Toyoshima
- Organizer
  第38回日本分子生物学会第88回日本生化学会合同大会(ワークショップオーガナイザー)
- Place of Presentation
  神戸ポートアイランド(兵庫県神戸市)
- Year and Date
  2015-12-02
- Description
  【発表確定】
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Sequential substitution of bound K^+ in the transmembrane binding sites of Na^+, K^+-ATPase : Kinetics by X-ray crystallography2015
- Author(s)
  H. Ogawa, A. Hirata, F. Cornelius, C. Toyoshima
- Organizer
  日本生物物理学会第53回年会シンポジウム「輸送膜タンパク質のダイナミクス」
- Place of Presentation
  金沢大学(石川県金沢市)
- Year and Date
  2015-09-15
- Description
  【発行確定】
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] イオンポンプ蛋白質の構造生物学とSPring-82015
- Author(s)
  豊島近
- Organizer
  SPring-8シンポジウム2015
- Place of Presentation
  九州大学(福岡市)
- Year and Date
  2015-09-13
- Description
  【発行確定】
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] New crystal structures of Ca^<2+>-and Na^+, K^+-ATPases2014
- Author(s)
  C. Toyoshima
- Organizer
  ASBMB Special Symposia Series, Na, K-ATPase and Related Transport ATPases
- Place of Presentation
  De Werelt Conference Centre, Lunteren, オランダ
- Year and Date
  2014-09-01
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] New crystal structures of Ca^<2+>-ATPase(SERCA) and Na^+, K^+-ATPases2014
- Author(s)
  C. Toyoshima
- Organizer
  Barcelona BioMed Conference, Transporters and other molecular machines
- Place of Presentation
  the Sala Prat de Riba バルセロナ, スペイン
- Year and Date
  2014-11-18
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] イオンポンプの構造生物学 : 全ての反射点の利用2013
- Author(s)
  豊島近
- Organizer
  第13回日本蛋白質科学会年会
- Place of Presentation
  とりぎん文化会館(鳥取市)
- Year and Date
  2013-06-14
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Electron Crystallography of 3D Protein Crystals2013
- Author(s)
  K. Yonekura, C. Toyoshima
- Organizer
  Nagoya Symposium - Frontiers in Structural Physiology
- Place of Presentation
  Nagoya University (Nagoya)
- Data Source
  KAKENHI-PROJECT-24657111
[Presentation] Structural Understanding of ion Pumping by P-type ATPases.2013
- Author(s)
  C. Toyoshima
- Organizer
  Benzon Symposium No. 59
- Place of Presentation
  Hotel Skt. Petriコペンハーゲンデンマーク
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] Do lipid bilayers followmovements of transmembrane helices? If so, to what extent2011
- Author(s)
  C. Toyoshima
- Organizer
  The EMBO Meeting
- Place of Presentation
  Vienna, Austria
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] Do lipid bilayers follow movements of transmembrane helices? If so, to what extent?2011
- Author(s)
  C.Toyoshima
- Organizer
  The EMBO Meeting 2011
- Place of Presentation
  Vienna, Austria(招待講演)
- Year and Date
  2011-09-12
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] カルシウムATPaseの作動機構の理解と結晶構造解析2011
- Author(s)
  豊島近
- Organizer
  第84回日本生化学会大会
- Place of Presentation
  京都(招待講演)
- Year and Date
  2011-09-22
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] A structural view on ionpumping by Ca^<2+>-ATPase2010
- Author(s)
  C. Toyoshima
- Organizer
  FASEB SummerResearch Conferences, Transport ATPase : From molecules to maladies
- Place of Presentation
  Snowmass, Colorado, USA(Key Note Lecture)
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] 放射光が明らかにするCa^<2+>ポンプのイオン輸送機構2010
- Author(s)
  豊島近
- Organizer
  ノーベル化学賞記念シンポジウム
- Place of Presentation
  東京
- Year and Date
  2010-03-06
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] A Structural view on ion pumping by Ca^<2+>-ATPase.2010
- Author(s)
  C.Toyoshima
- Organizer
  2010FASEB Summer Research Conferences
- Place of Presentation
  Snowmass Village, Colorado USA
- Year and Date
  2010-06-06
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] Structural aspects of cation pumping by P-type ATPase2009
- Author(s)
  豊島近
- Organizer
  XXXVI International Congress of Physiological Sciences
- Place of Presentation
  京都
- Year and Date
  2009-07-29
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] 結晶構造から見たCa^<2+>-ATPaseのイオン輸送・エネルギー変換機構2009
- Author(s)
  豊島近
- Organizer
  日本生体エネルギー研究会第35回討論会
- Place of Presentation
  旭川
- Year and Date
  2009-12-19
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] How Ca2+ATPase pumps ionsacross the sarcoplasmic reticulummembrane2008
- Author(s)
  C. Toyoshima
- Organizer
  1st Sir Michael BerridgeLecture, 10th Symposium of the EuropeanCalcium Society
- Place of Presentation
  Leuven, Belgium
- Year and Date
  2008-09-17
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] How Ca^<2+>-ATPase Pump ion across the membrane2008
- Author(s)
  C. Toyoshima
- Organizer
  SPring-8 GPCR Symposium
- Place of Presentation
  兵庫県・佐用郡
- Year and Date
  2008-02-26
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] A Molecular Machine at Works : The Case of the Calcium Pump Protein2008
- Author(s)
  C. Toyoshima
- Organizer
  Maestro Lectures on Structure and Function of Membrane Proteins
- Place of Presentation
  台湾・台北市
- Year and Date
  2008-11-20
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] A Molecular Machine at Works2008
- Author(s)
  C. Toyoshima
- Organizer
  The Case of the Calcium Pump Protein
- Place of Presentation
  Berkeley, USA
- Year and Date
  2008-05-01
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] A Molecular Machine at Works : The case of the calcium pump protein2008
- Author(s)
  C. Toyoshima
- Organizer
  The Charles M. and Martha HITCHCOCK LECTURES
- Place of Presentation
  アメリカ・バークレー
- Year and Date
  2008-05-01
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] How Ca^<2+> ATPase pumps ions across the salcoplasmic reticulum membrane2008
- Author(s)
  C. Toyoshima
- Organizer
  第10回欧州カルシウム学会シンポジウム
- Place of Presentation
  ベルギー・レーベン
- Year and Date
  2008-09-17
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] Calcium, Proteins, Energy, and Life2008
- Author(s)
  C. Toyoshima
- Organizer
  Hitchcock Lecture
- Place of Presentation
  Berkeley, California, USA
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] Crystallization of the calcium pump of skeletal muscle sarcoplasmic reticulum2008
- Author(s)
  C. Toyoshima
- Organizer
  第21回国際結晶学連合会議
- Place of Presentation
  大阪市
- Year and Date
  2008-08-29
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] How does Ca^<2+>-ATPase pumpions across the membrane2007
- Author(s)
  C. Toyoshima
- Organizer
  The LuigiSacconi Memorial Lecture in Chemistry
- Place of Presentation
  Florence, Italy
- Year and Date
  2007-12-30
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] How does Ca^<2+>-ATPase pump ions across the membrane?2007
- Author(s)
  C. Toyoshima
- Organizer
  The Luigi Sacconi Memorial Lecture in Chemistry
- Place of Presentation
  イタリア・フローレンス
- Year and Date
  2007-10-30
- Data Source
  KAKENHI-PROJECT-19002013
[Presentation] Structural study on the calcium ATPase: ion pumping mechanism and its regulation
- Author(s)
  C. Toyoshima
- Organizer
  The 1st NRPB International Symposium and Workshop for Membrane Proteins
- Place of Presentation
  Academia Sinica, Taipei, Taiwan
- Invited
- Data Source
  KAKENHI-PROJECT-23000014
[Presentation] How Na^+, K^+-ATPase select andpumps sodium across the membrane, Visualization of lipid bilayers in the crystals of calcium pump
- Author(s)
  C. Toyoshima
- Organizer
  2nd NTU Membrane Protein Weeks
- Place of Presentation
  台湾大学台北市, 台湾
- Year and Date
  2015-03-23 – 2015-03-25
- Invited
- Data Source
  KAKENHI-PROJECT-23000014

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Toyoshima Chikashi 豊島 近

TOYOSHIMA Chikashi 豊島 近

Research Projects

Research Products

Co-Researchers

イオンポンプ蛋白質作動機構の構造的理解の完成とその高次機能の構造生物学への発展Principal Investigator

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Development of artificial reaction intermediates by introduction of steric hindrancePrincipal Investigator

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Developement of technology for visualising lipid bilayers in crystals of membrane proteinsPrincipal Investigator

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Structural biology of active transport and its regulation by P-type ATPasesPrincipal Investigator

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Structural elucidation of active transport by P-type ATPasesPrincipal Investigator

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Structural biology of membrane transporters with a view to drug developmentPrincipal Investigator

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Structural biology of ion transportersPrincipal Investigator

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薬剤開発を視野に入れたイオンポンプの構造研究Principal Investigator

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P型イオンポンプによる能動輪送機構の構造的解明Principal Investigator

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Ca-ATPaseの電子線・X線結晶解析Principal Investigator

Principal Investigator

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Crystallographics study of active ion transportPrincipal Investigator

Toyoshima Chikashi 豊島近

TOYOSHIMA Chikashi 豊島近