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Toyoshima Chikashi  豊島 近

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TOYOSHIMA Chikashi  豊島 近

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Researcher Number 70172210
Other IDs
External Links
Affiliation (Current) 2022: 東京大学, 定量生命科学研究所, 特任教授
Affiliation (based on the past Project Information) *help 2020 – 2022: 東京大学, 定量生命科学研究所, 特任教授
2017 – 2019: 東京大学, 定量生命科学研究所, 教授
1994 – 2016: The University of Tokyo, Institute of Molecular and Cellular Biosciences, Professor, 分子細胞生物学研究所, 教授
1995: 東京大学, 分子細胞生物研究所, 教授
1991 – 1993: 東京工業大学, 生命理工学部, 助教授
1990: 東京工業部学, 理学部, 助教授
Review Section/Research Field
Principal Investigator
Biophysics / 生物物性学 / Biological Sciences / Biophysics / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Except Principal Investigator
Biophysics / 生物物性学 / Biophysics / Neuroscience in general / 医薬分子機能学 / Biological Sciences / Basic Section 49010:Pathological biochemistry-related / Medium-sized Section 49:Pathology, infection/immunology, and related fields
Keywords
Principal Investigator
膜蛋白質 / イオンポンプ / 蛋白質結晶 / ATPase / 結晶解析 / 能動輸送 / X線結晶解析 / 三次元構造解析 / 低温電子顕微鏡法 / 三次元構造 … More / membrane proteins / ion pump / 構造解析 / 氷包埋法 / 電子顕微鏡 / active transport / 筋小胞体 / 電子線結晶解析 / three-dimensional structure / protein crystal / electron crystallography / X-ray crystallography / 構造生物学 / カルシウムATPase / 二次元結晶 / 画像解析 / 脂質二重膜 / 生物物理 / エネルギー変換 / cryo-electron microscopy / sarcoplasmic reticulum / 電子線回折 / Protein crystals / カルシウムポンプ / structural analysis / チトクローム酸化酵素 / 電子伝達系 / 呼吸鎖酵素 / チトクロム酸化酵素 / チトクロムbc1複合体 / X線結晶 / エネルギー交換 / 閃光光分解 / caged物質 / 時間分解 / 氷胞埋法 / 急速凍結法 / flash photolysis / ice embedding / caged compounds / time-resolved / カルシウム / 構造変化 / calcium / three-dimensional structural / membrance proteins / 電子線損傷 / クライオトランスファー / 電子線回析 / 低電子線量法 / CCDカメラ / 電子線 / Electron microscope / Electron diffraction / Ice embedding / Structural analysis / Radiation damage / Cryo-transfer / アセチルコリン受容体 / イオンチャンネル / Acetylcholine receptor / Ion channel / Electron microscopy / Structural study / Membrane proteins / calcium pump / electron microscopy / 大量発現 / over expression / クライオ電子顕微鏡 / 低温試料ホルダー / データ収集 / electron diffraction / crystallography / structure analysis / cryo electron microscopy / cryo holder / data collection / 蛋白質 / 結晶 / 結晶大型化 / ナトリウムポンプ … More
Except Principal Investigator
膜蛋白質 / 構造生物学 / 超分子複合体 / L型Caチャンネル / ジヒドロピリジン化合物 / エナンチオマー / Naチャンネル / 二次元結晶 / 電子線構造解析 / 生体膜 / 電子顕微鏡 / 光学分割 / イオンチャネル / クローニング / 結晶構造解析 / 膜タンパク質 / X線結晶構造解析 / 高次構造 / シンクロトロン放射光 / TRNOE / 神経変性疾患 / 神経細胞死 / 異常凝集体 / アルツハイマー病 / 蛋白質の結晶化 / バクテリオロドプシン / プロトン輸送 / 電子線回折 / バキュロウイルス / NMDAレセプター / 大量生産 / メタノール資化性菌 / 翻訳開始部位 / 転移ベクター / 融合遺伝子 / 発現プロモーター / トリチウム標識 / 水チャネル / トランスポータ / カルシウムポンプ / 構造・機能相関 / Ca2+-ATPase / カタラーゼ / 結晶化 / 結晶成長機構 / タンパク質立体構造予測 / タンパク質立体構造形成機構 / チトクロム酸化酵素 / チトクロムbc_1複合体 / Membrane protein / Supermolecular complex / X-ray crystallographic analysis / Electron micrographic analysis / Folding mechanism / Crystal growth mechanism / Crystallization / Three dimensional-stractural prediction / 動的構造 / モデルチャネル / パッチクランプ / 分子生物学 / クライオ電顕 / 分子動力学 / 動的構造機能連関 / チャネル蛋白質 / 電気生理学 / 合成チャネル / Ion channels / Higher order structure / Dynamical structure / Model channel / Patch clamp / Molecular biology / Cryo-electron microscopy / タンパク質結晶学 / X線構造解析 / シンクロトン放射光 / シンクロトロン放射学 / Protein Crystallography / Structural Biology / X-ray Structure Analysis / Supramacromolecular Complex / Synchrotron Radiation / 受容体 / 大量発現 / 神経伝達物質 / Gタンパク質 / アセチルコリン / ムスカリン / レセプター / 伝達物質 / Receptor / Conformation / Large-Scale Purification / Transmitter / G Protein / Acetylcholine / Muscarine / 細胞内小器官 / 細胞内膜系 / 非膜系高次構造 / 生体超分子 / 細胞内脂質輸送 / 人工脂質膜 / 球殻状集合体 / チューブ状集合体 / 膜小胞 / 細胞運動 / 蛋白質集合体 / 蛋白質の自己集合 / cell organelle / intracellular membranes / non-membrane higher ordered structure / biological supramolecules / intracellular traffic of lipids / artificial lipid membranes / spherical assembly / tubular assembly / Ca拮抗薬 / 光アフィニティ ラベリング / 薬物結合部位 / 新規化合物 / ドラッグデザイン / 光アフィニティラベリング / 心筋Caチャンネル / 精密合成化学 / 抗ペプチド抗体 / 薬理活性 / Calcium antagonist / photoaffinity labeling / drug binding site / structural biology / new compounds / drug design / 生物マシーナリー / 生体高分子複合体 / 生体高分子集合系 / X線結晶学 / 蛋白結晶学 / Biological machineries / Synchrotron radiation / Structural biology / X-ray crystallography / Complex of biomacromolecules / Group of biomacromolecules / membrane proteins / 診断方法 / ナトリウムポンプ / タンパク質ータンパク質相互作用 / ペプチド創薬 / コンパニオン診断薬 / 治療法 Less
  • Research Projects

    (36 results)
  • Research Products

    (106 results)
  • Co-Researchers

    (82 People)
  •  多機能化一本鎖抗体によるアミロイドβ凝集体細胞内スワイプ療法の開発

    • Principal Investigator
      星 美奈子
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 49:Pathology, infection/immunology, and related fields
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  Developement of technology for visualising lipid bilayers in crystals of membrane proteinsPrincipal Investigator

    • Principal Investigator
      Toyoshima Chikashi
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Challenging Research (Pioneering)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      The University of Tokyo
  •  異常凝集体に対する体外診断法開発によるアルツハイマー病の早期診断と病態解明

    • Principal Investigator
      星 美奈子
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 49010:Pathological biochemistry-related
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe
  •  Structural biology of active transport and its regulation by P-type ATPasesPrincipal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Review Section
      Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
    • Research Institution
      The University of Tokyo
  •  Structural elucidation of active transport by P-type ATPasesPrincipal Investigator

    • Principal Investigator
      Toyoshima Chikashi
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  Visualization of Coulomb potential by electron crystallography

    • Principal Investigator
      YONEKURA Koji
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Biophysics
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Structural biology of membrane transporters with a view to drug developmentPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      2011 – 2016
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Structural biology of ion transportersPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  薬剤開発を視野に入れたイオンポンプの構造研究Principal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      2007 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  P型イオンポンプによる能動輪送機構の構造的解明Principal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      The University of Tokyo
  •  Ca-ATPaseの電子線・X線結晶解析Principal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      1999 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Crystallographics study of active ion transportPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1999 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  Structural elucidation of active ion transportPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  Structural Biology of Biological Machineries through X-ray Protein Crystallography Reinforced by Synchrotron Radiation

    • Principal Investigator
      TANOKURA Masaru, 三井 幸雄
    • Project Period (FY)
      1998 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
      Nagaoka University of Technology
  •  Development of electron diffraction methods for protein crystallographyPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  Crystallographic study of calcium ion pump of sarcoplasmic reticulumPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  イオンチャンネル機能を実現する超分子構造の化学的,物理学的解析

    • Principal Investigator
      中山 仁
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  Structural Basis of Active Transport by Ion PumpsPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
  •  Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels

    • Principal Investigator
      NAKAYAMA Hitoshi
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      医薬分子機能学
    • Research Institution
      Kumamoto University
  •  イオンチャンネル機能を実現する超分子構造の化学的、物理学的解析

    • Principal Investigator
      中山 仁
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  チャネルとトランスポータの構造・機能相関

    • Principal Investigator
      岡田 泰伸
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okazaki National Research Institutes
  •  Elucidation of the organization mechanism of dynamic higher-ordered structures in biological cells

    • Principal Investigator
      KOUYAMA Tsutomu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Biophysics
    • Research Institution
      Nagoya University
  •  化学的,物理学的手法によるイオンチャンネル超分子構造の解析

    • Principal Investigator
      NAKAYAMA Hitoshi
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  NMDAレセプターの大量生産とその三次元構造解析

    • Principal Investigator
      山根 和彦
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Gating mechanism of the acetylcholine receptor ion channelPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      The University of Tokyo
  •  New Generation of Protein Crystallography

    • Principal Investigator
      MIKI Kunio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Biophysics
    • Research Institution
      KYOTO UNIVERSITY
  •  Conformation of the Muscarinic Acetylcholine Receptor

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neuroscience in general
    • Research Institution
      University of Tokyo
  •  低温電子顕微鏡法による呼吸鎖酵素複合体二次元結晶の三次元構造解析Principal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  PIONEERING RESEARCH ON THE DYNAMICAL ASPECT OF STRUCTURE-FUNTION RELATIONSHIP IN ION CHANNELS

    • Principal Investigator
      SOKABE Masahiro
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Biophysics
    • Research Institution
      Nagoya University
  •  Development of technologise for three-dimensional structural analysis of protein crystals using electron microscopePrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (A)
    • Research Field
      Biophysics
    • Research Institution
      The University of Tokyo
      Tokyo Institute of Technology
  •  低温電子顕微鏡による呼吸鎖酵素複合合体二次元結晶の三次元構造解析Principal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Institute of Technology
  •  Three-dimensional strutural study of the sarcoplasmic reticulum clcium ATPase under various physiological conditions.Principal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      生物物性学
    • Research Institution
      Tokyo Institute of Technology
  •  氷包埋低温電子顕微鏡によるカルシウムATPaseの三次元構造解析Principal Investigator

    • Principal Investigator
      豊島 近
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      生物物性学
    • Research Institution
      Tokyo Institute of Technology
  •  Time-resolved 3-dimensional Structural Study of Biological Reactions by Flash Photolysis and Frozen-hydrated Electron MicroscopyPrincipal Investigator

    • Principal Investigator
      TOYOSHIMA Chikashi
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      生物物性学
    • Research Institution
      Tokyo Institute of Technology
  •  膜蛋白質3次元微結晶の電子線構造解析

    • Principal Investigator
      KOUYAMA Tsutomu
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      生物物性学
    • Research Institution
      The Institute of Physical and Chemical Research
  •  Folding and crystallization conditions of menbrane protein supercomplexes

    • Principal Investigator
      YOSHIKAWA Shinya
    • Project Period (FY)
      1990 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      生物物性学
    • Research Institution
      Himeji Institute of Technology

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2011 2010 2009 2008 2007 2004 Other

All Journal Article Presentation

  • [Journal Article] Cryoelectron microscopy of Na+,K+-ATPase in the two E2P states with and without cardiotonic steroids.2022

    • Author(s)
      Ryuta Kanai , Flemming Corneliusb , Bente Vilsenb , Chikashi Toyoshima
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 119

    • DOI

      10.1073/pnas.2123226119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Journal Article] Binding of cardiotonic steroids to Na+,K+-ATPase in the E2P state.2021

    • Author(s)
      Kanai Ryuta、Cornelius Flemming、Ogawa Haruo、Motoyama Kanna、Vilsen Bente、Toyoshima Chikashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Pages: 1-12

    • DOI

      10.1073/pnas.2020438118

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-20K20376, KAKENHI-PROJECT-19H00975
  • [Journal Article] What ATP binding does to the Ca2+pump and how nonproductive phosphoryl transfer is prevented in the absence of Ca2+2020

    • Author(s)
      Kabashima Yoshiki、Ogawa Haruo、Nakajima Rie、Toyoshima Chikashi
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Pages: 18448-18458

    • DOI

      10.1073/pnas.2006027117

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20376, KAKENHI-PROJECT-19H00975
  • [Journal Article] X線コントラスト変調法によって明らかになった膜蛋白質と燐脂質の相互作用のダイナミクス2018

    • Author(s)
      豊島 近、乗松 良行
    • Journal Title

      放射光

      Volume: 31 Pages: 212-218

    • NAID

      40021599683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Journal Article] Suppressor mutation analysis combined with 3D modeling explains cohesin’s capacity to hold and release DNA2018

    • Author(s)
      Xu Xingya、Kanai Ryuta、Nakazawa Norihiko、Wang Li、Toyoshima Chikashi、Yanagida Mitsuhiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115

    • DOI

      10.1073/pnas.1803564115

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06148, KAKENHI-PROJECT-16H02499, KAKENHI-PROJECT-16K18500
  • [Journal Article] X線コントラスト変調法によって明らかになった膜蛋白質と燐脂質の相互作用のダイナミクス2018

    • Author(s)
      豊島 近、乗松 良行
    • Journal Title

      放射光

      Volume: 31 Pages: 212-218

    • NAID

      40021599683

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Journal Article] Mechanism of the E2 to E1 transition in Ca2+ pump revealed by crystal structures of gating residue mutants.2018

    • Author(s)
      Naoki Tsunekawa, Haruo Ogawa, Junko Tsueda, Toshihiko Akiba, and Chikashi Toyoshima
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 115 Pages: 12722-12727

    • DOI

      10.1073/pnas.1815472115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Journal Article] Distinct pH dependencies of Na+/K+selectivity at the two faces of Na,K-ATPase2017

    • Author(s)
      Cornelius Flemming、Tsunekawa Naoki、Toyoshima Chikashi
    • Journal Title

      Journal of Biological Chemistry

      Volume: 293 Pages: 2195-2205

    • DOI

      10.1074/jbc.ra117.000700

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Journal Article] Protein-lipid interplay revealed with crystals of a Calcium pump2017

    • Author(s)
      Norimatsu, Y and Toyoshima, C
    • Journal Title

      Nature

      Volume: 545 Pages: 193-198

    • DOI

      10.1038/nature22357

    • Description
      掲載確定
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-16H02499
  • [Journal Article] The road to understanding an ion pump2016

    • Author(s)
      Toyoshima, C
    • Journal Title

      PHYSICA SCRIPTA

      Volume: 91 Pages: 042501-042501

    • DOI

      10.1088/0031-8949/91/4/042501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-16H02499
  • [Journal Article] Mn^<2+> transport by Ca^<2+>-ATPase of sarcoplasmic reticulum2016

    • Author(s)
      Yonekura, SI and Toyoshima, C
    • Journal Title

      FEBS Letters

      Volume: 590 Pages: 2086-2095

    • DOI

      10.1002/1873-3468.12244

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-16H02499
  • [Journal Article] Stimulation, inhibition, or stabilization of Na,K-ATPase caused by specific lipid interactions at distinct sites2015

    • Author(s)
      M. Habeck, H. Haviv, A. Katz, E. Kapri-Pardes, S. Ayciriex, A. Shevchenko, H. Ogawa, C. Toyoshima, and S.J.D. Karlish
    • Journal Title

      J. Biol. Chem.

      Volume: 290 Pages: 1406-1411

    • DOI

      10.1074/jbc.m114.611384

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012
  • [Journal Article] Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca^<2+> pumps with a unique mode of binding2015

    • Author(s)
      M. Morita, H. Ogawa, O. Ohno, T. Yamori, K. Suenaga, C. Toyoshima
    • Journal Title

      FEBS Letters

      Volume: 589 Pages: 1406-1411

    • DOI

      10.1016/j.febslet.2015.04.056

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-23000014
  • [Journal Article] Functional analysis of SERCA1b, a highly expressed SERCA1 variant in myotonic dystrophy type I muscle2015

    • Author(s)
      YM. Zhao, H. Ogawa, SI. Yonekura, H. Mitsuhashi, S. Mitsuhashi, I. Nishino, C. Toyoshima, S. Ishiura
    • Journal Title

      Biochimica et Biophysica Acta- MOLECULAR BASIS OF DISEASE

      Volume: 1852 Pages: 2042-2047

    • DOI

      10.1016/j.bbadis.2015.07.006

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-23000014
  • [Journal Article] Sequential substitution of K^+ bound to Na^+, K^+ -ATPase visualised by X-ray crystallography2015

    • Author(s)
      H. Ogawa, F. Cornelius, A. Hirata and C. Toyoshima
    • Journal Title

      Nature Communications

      Volume: 6 Pages: 8004-8004

    • DOI

      10.1038/ncomms9004

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25650020, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-23000014
  • [Journal Article] Electron crystallography of ultra-thin 3D protein crystals: atomic model with charges2015

    • Author(s)
      K. Yonekura, K. Kato, M. Ogasawara, M. Tomita and C. Toyoshima
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 112 Pages: 3368-3373

    • DOI

      10.1073/pnas.1500724112

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-24657111
  • [Journal Article] General and specific lipid-protein interactions in Na, K-ATPase2015

    • Author(s)
      F. Cornelius, M. Habeck, R. Kanai, C. Toyoshima and S. J. D. Karlish
    • Journal Title

      Biochimica et Biophysica Acta-Biomembranes

      Volume: 1848 Pages: 1729-1743

    • DOI

      10.1016/j.bbamem.2015.03.012

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Journal Article] Biselyngbyasides, cytotoxic marine macrolides, are novel and potent inhibitors of the Ca^<2+>pumps with a unique mode of binding2015

    • Author(s)
      M. Morita, H. Ogawa, 0. Ohno, T. Yamori, K. Suenaga, C. Toyoshima
    • Journal Title

      FEBS Letters

    • Description
      【掲載確定】 印刷中
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Journal Article] ATPase-dependent auto-phosphorylation of the open condensin hinge diminishes DNA binding2014

    • Author(s)
      Y. Akai, R. Kanai, N. Nakazawa, M. Ebe, C. Toyoshima and M. Yanagida
    • Journal Title

      Open Biology

      Volume: 4 Pages: 140193-140193

    • DOI

      10.1098/rsob.140193

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PROJECT-25840013
  • [Journal Article] Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state2013

    • Author(s)
      C. Toyoshima
    • Journal Title

      Nature

      Volume: 495 Pages: 260-264

    • DOI

      10.1038/nature11899

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-25650020
  • [Journal Article] New crystal structures of PII-type ATPases : Excitement continues.2013

    • Author(s)
      C. Toyoshima and F. Cornelius
    • Journal Title

      Curr. Opinion Struct. Biol.

      Volume: 23 Pages: 507-514

    • DOI

      10.1016/j.sbi.2013.06.005

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Journal Article] Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state2013

    • Author(s)
      R. Kanai, H. Ogawa, B. Vilsen, F. Cornelius and C. Toyoshima
    • Journal Title

      Nature

      Volume: 502 Pages: 201-206

    • DOI

      10.1038/nature12578

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014, KAKENHI-PUBLICLY-25136702, KAKENHI-PROJECT-25291012, KAKENHI-PROJECT-25650020
  • [Journal Article] First crystal structures of Na^+, K^+-ATPase : New light on the oldest ion pump2011

    • Author(s)
      C.Toyoshima, et al.
    • Journal Title

      Structure

      Volume: 19 Pages: 1732-1738

    • DOI

      10.1016/j.str.2011.10.016

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Journal Article] Trinitrophenyl-derivatives bind differently from parent adenine nucleotides to Ca^<2+>-ATPase in the absence of Ca^<2+>2011

    • Author(s)
      C.Toyoshima
    • Journal Title

      Proc.Nat.Acad.Sci.USA.

      Volume: 108 Pages: 1833-1838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Trinitrophenyl derivatives bind differently from parent adenine nucleotides to Ca^<2+>-ATPase in the absence of Ca^<2+>2011

    • Author(s)
      C. Toyoshima, S. Yonekura, J. Tsueda and S. Iwasawa
    • Journal Title

      Proc. Nat. Acad. Sci. USA

      Volume: 108 Pages: 1833-1838

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Cornelius : First crystal structures of Na+, K^+-ATPase : New light on the oldestion pump2011

    • Author(s)
      C. Toyoshima, R. Kanai and F
    • Journal Title

      Structure

      Volume: 19 Pages: 1732-1738

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] イオンポンプ(P型ATPase)の構造生物学2011

    • Author(s)
      豊島近
    • Journal Title

      放射光

      Volume: 24 Pages: 2-9

    • NAID

      10027411840

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase.2009

    • Author(s)
      T. Tsuda, C. Toyoshima
    • Journal Title

      EMBO J. 28

      Pages: 1782-1791

    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Nucleotide recognition by CopA, a Cu+-transporting P-type ATPase2009

    • Author(s)
      T. Tsuda and C. Toyoshima
    • Journal Title

      EMBO J

      Volume: 28 Pages: 1782-1791

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Crystal tructure of the sodium-potassium pump (Na+, K+-ATPase)with bound potassium and ouabain.2009

    • Author(s)
      H. Ogawa, T. Shinoda, F. Cornelius, C. Toyoshima
    • Journal Title

      Proc. Nat. Acad. Sci. USA 106

      Pages: 13742-13747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] How Ca^<2+>-ATPase pumps ions across the sarcoplasmic reticulum membrane2009

    • Author(s)
      C.Toyoshima
    • Journal Title

      Biochem.Biophys.Acta 1793

      Pages: 941-946

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Crystal structure of the sodium-potassium pump at 2. 4 A resolution2009

    • Author(s)
      T. Shinoda, H. Ogawa, F. Cornelius and C. Toyoshima
    • Journal Title

      Nature

      Volume: 459 Pages: 446-450

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Crystal structure of the sodium-potassium pump at 2. 4 A resolution.2009

    • Author(s)
      T. Shinoda, H. Ogawa, F. Cornelius, C. Toyoshima
    • Journal Title

      Nature 459

      Pages: 446-450

    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Crystal structure of thesodium-potassium pump(Na^+, K^+-ATPase) withbound potassium and ouabain2009

    • Author(s)
      H. Ogawa, T. Shinoda, F. Cornelius and C. Toyoshima
    • Journal Title

      Proc. Nat. Acad. Sci. USA

      Volume: 106 Pages: 13742-13747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Structural aspects of ion pumping by Ca^<2+>-ATPase of sarcoplasmic reticulum2008

    • Author(s)
      C. Toyoshima
    • Journal Title

      Arch. Biochem. Biophys 476

      Pages: 3-11

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Structural aspects of ion pumping by Ca2+-ATPase of sarcoplasmic reticulum.2008

    • Author(s)
      C. Toyoshima
    • Journal Title

      Arch. Biochem. Biophys. 476

      Pages: 3-11

    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Conformationalfluctuations of the Ca^<2+>-ATPase in thenative membrane environment2008

    • Author(s)
      G. Inesi, D. Lewis, C. Toyoshima, A. Hirata and L. de Meis
    • Journal Title

      J. Biol. Chem

      Volume: 283 Pages: 1189-1196

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] How processing ofaspartylphosphate is coupled to lumenalgating of the ion pathway in the calciumpump2007

    • Author(s)
      C. Toyoshima, Y. Norimatsu, S. Iwasawa, T. Tsuda and H. Ogawa
    • Journal Title

      Proc. Nat. Acad. Sci.

      Volume: 104 Pages: 19831-19836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump2007

    • Author(s)
      C. Toyoshima
    • Journal Title

      Proc. Nat. Acad. Sci. USA. 104

      Pages: 19831-19836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Domain organization and movements in heavy metal ion pumps : Papain digestion of CopA, a Cu^+-transporting ATPase2007

    • Author(s)
      Y. Hatori, E. Majima, T. Tsuda and C. Toyoshima
    • Journal Title

      J. Biol. Chem

      Volume: 282 Pages: 25213-25221

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Interdomain communication incalcium pump as revealed in the crystalstructures with transmembrane inhibitors2007

    • Author(s)
      M. Takahashi, Y. Kondou and C. Toyoshima
    • Journal Title

      Proc. Nat. Acad. Sci.

      Volume: 104 Pages: 5800-5805

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] How processing of aspartylphosphate is coupled to lumenal gating of the ion pathway in the calcium pump.2007

    • Author(s)
      C. Toyoshima, Y. Norimatsu, S. Iwasawa, T. Tsuda, H. Ogawa
    • Journal Title

      Proc. Nat. Acad. Sci. USA. 104

      Pages: 19831-19836

    • Data Source
      KAKENHI-PROJECT-19002013
  • [Journal Article] Structural basis of ion pumping by Ca^<2+> -ATPase of the sarcoplasmic reticulum2004

    • Author(s)
      C.Toyoshima
    • Journal Title

      Ann.Rev.Biochem. 73

      Pages: 269-92

    • Data Source
      KAKENHI-PROJECT-14GS0308
  • [Journal Article] Lumenal gating mechanism revealed in calcium pump crystal structures with phosphate analogues.2004

    • Author(s)
      C.Toyoshima
    • Journal Title

      Nature 432

      Pages: 361-368

    • Data Source
      KAKENHI-PROJECT-14GS0308
  • [Journal Article] Crystal structure of the calcium pump wlth a bound ATP analogue.2004

    • Author(s)
      C.Toyoshima
    • Journal Title

      Nature 430

      Pages: 529-535

    • Data Source
      KAKENHI-PROJECT-14GS0308
  • [Presentation] What is the activation signal for phosphoryl transfer in the calcium2019

    • Author(s)
      豊島 近
    • Organizer
      Honorary Skou Professor Seminar,Aarhus University, Aarhus, Denmark
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H00975
  • [Presentation] P 型 ATPase によるイオン輸送とその制御機構2019

    • Author(s)
      豊島 近
    • Organizer
      日本薬学会 第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] イオンポンプの構造生物学:脂質二重膜からプロトンまで2019

    • Author(s)
      豊島 近
    • Organizer
      2019年度iBIX-JAXA-KEK物構研-QST合同研究会「クライオEM、X線、中性子タンパク質構造解析の住み分け」
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] イオンポンプの構造生物学:脂質二重膜からプロトンまで2019

    • Author(s)
      豊島 近
    • Organizer
      2019年度iBIX-JAXA-KEK物構研-QST合同研究会「クライオEM、X線、中性子タンパク質構造解析の住み分け」
    • Data Source
      KAKENHI-PROJECT-19H00975
  • [Presentation] What is the activation signal for phosphoryl transfer in the calcium2019

    • Author(s)
      豊島 近
    • Organizer
      Honorary Skou Professor Seminar,Aarhus University, Aarhus, Denmark
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] P 型 ATPase によるイオン輸送とその制御機構2019

    • Author(s)
      豊島 近
    • Organizer
      日本薬学会 第139年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Structural Biology of Ion Pumps2018

    • Author(s)
      豊島 近
    • Organizer
      Post Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] Role of phospholipids in ion pumping2018

    • Author(s)
      豊島 近
    • Organizer
      5th ShanghaiTech-SIAIS BioForum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] Structural Biology of Ion Pumps2018

    • Author(s)
      豊島 近
    • Organizer
      The 2nd International Symposium on Chemical Communication
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] イオンポンプの構造生物学:膜の可視化から量子化学計算まで2018

    • Author(s)
      豊島 近
    • Organizer
      生理研プロジェクト「機能タンパク質の構造と機能のダイナミクスと、それに基づく細胞・生体シス テム 作動機構の研究拠点の形成」平成29年度成果報告会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] 原子構造に基づく筋小胞体カルシウムポンプの制御機構2018

    • Author(s)
      豊島 近
    • Organizer
      日本筋学会第4会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] カルシウムポンプの結晶構造解析の現状2018

    • Author(s)
      豊島 近
    • Organizer
      第2回SPring-8における蛋白質構造生物学研究の現状と将来
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Structural Biology of the Calcium Pump2018

    • Author(s)
      豊島 近
    • Organizer
      第18回国際薬理学・臨床薬理学会議
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] Structural Biology of the Calcium Pump2018

    • Author(s)
      豊島 近
    • Organizer
      第18回国際薬理学・臨床薬理学会議
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] カルシウムポンプの結晶構造解析の現状2018

    • Author(s)
      豊島 近
    • Organizer
      第2回SPring-8における蛋白質構造生物学研究の現状と将来
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] Role of phospholipids in ion pumping2018

    • Author(s)
      豊島 近
    • Organizer
      5th ShanghaiTech-SIAIS BioForum
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] 原子構造に基づく筋小胞体カルシウムポンプの制御機構2018

    • Author(s)
      豊島 近
    • Organizer
      日本筋学会第4会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-20K20376
  • [Presentation] Structural Biology of Ion Pumps2018

    • Author(s)
      豊島 近
    • Organizer
      The 2nd International Symposium on Chemical Communication
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Structural Biology of Ion Pumps2018

    • Author(s)
      豊島 近
    • Organizer
      Post Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Crystal structure analysis of Ca2+- and Na+,K+-ATPases2017

    • Author(s)
      豊島 近
    • Organizer
      The 15th International Conference on Na,K-ATPase and Related Transport ATPases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] カルシウムポンプの構造生物学 - 燐脂質との相互作用2017

    • Author(s)
      豊島 近
    • Organizer
      第2回生物構造学研究会
    • Place of Presentation
      研究社英語センター大会議室(東京都新宿区)
    • Year and Date
      2017-03-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Protein-Lipid Interplay as Revealed by X-ray Solvent Contrast Modulation with the crystals of Ca^<2+>-ATPases in four different States2017

    • Author(s)
      豊島 近
    • Organizer
      IGER International Symposium on Physics of Life
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2017-03-26
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Crystal structure analysis of Ca2+- and Na+,K+-ATPases” The 15th International Conference on Na,K-ATPase and Related Transport ATPases2017

    • Author(s)
      豊島 近
    • Organizer
      The 15th International Conference on Na,K-ATPase and Related Transport ATPases
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Protein-lipid interplay revealed by X-ray solvent contrast modulation with calcium pump crystals2017

    • Author(s)
      豊島 近
    • Organizer
      19th IUPAB and 11th EBSA congress
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] イオンポンプの構造的理解の長い道2017

    • Author(s)
      豊島 近
    • Organizer
      第35回先端医療センター Monthly Lecture
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Structural biology of Na+,K+-ATPase: towards understanding of mutations in ATP1A32017

    • Author(s)
      豊島 近
    • Organizer
      第6回ATP1A3遺伝子関連疾患国際シンポジウム
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Protein-Lipid Interplay as Revealed by X-ray Solvent Contrast Modulation with the crystals of Ca2+-ATPases in four different States2017

    • Author(s)
      豊島 近
    • Organizer
      IGER International Symposium on Physics of Life
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] カルシウムポンプの構造生物学 - 燐脂質との相互作用2017

    • Author(s)
      豊島 近
    • Organizer
      第2回生物構造学研究会
    • Invited
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Structural Basis of Ion Pumping by Ca2+-ATPase2017

    • Author(s)
      豊島 近
    • Organizer
      第20回カルシウム結合蛋白質とカルシウム機構の生理と病態に関する国際シンポジウム(CaBP20)
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H02499
  • [Presentation] Large-scale production of mammalian membrane proteins toward determination of high resolution structures2017

    • Author(s)
      Haruo Ogawa, Chikashi Toyoshima
    • Organizer
      Biophysical Society 61st Annual Meeting
    • Place of Presentation
      Ernest N. Morial Convention Center(米国ニューオーリンズ)
    • Year and Date
      2017-02-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Stuructural biology of P-type ion translocating ATPases : towards complete understanding of the mechanism2016

    • Author(s)
      C. Toyoshima
    • Organizer
      Aminoff Prize Symposium2016
    • Place of Presentation
      University of Gothenburg (Gothenburg, Sweden)
    • Year and Date
      2016-03-30
    • Description
      【発行確定】
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] 高分解能構造解析へ向けた哺乳類由来膜蛋白質の大量生産2016

    • Author(s)
      小川治夫、村山尚、呉林なごみ、豊島近
    • Organizer
      第89回 日本生化学会大会シンポジウム
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-09-26
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Ca2+-ポンプ構造研究の最前線2016

    • Author(s)
      小川治夫、椛島佳樹、豊島近
    • Organizer
      日本生体エネルギー研究会第42回討論会
    • Place of Presentation
      名古屋工業大学4号館ホール(愛知県名古屋市)
    • Year and Date
      2016-12-20
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Kinetics by X-ray crystallography : sequential substitution of K^+ bound to Na^+, K^+-ATPase2015

    • Author(s)
      H. Ogawa, A. Hirata, F. Cornelius, C. Toyoshima
    • Organizer
      第38回日本分子生物学会 第88回日本生化学会合同大会(ワークショップオーガナイザー)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2015-12-02
    • Description
      【発表確定】
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Sequential substitution of bound K^+ in the transmembrane binding sites of Na^+, K^+-ATPase : Kinetics by X-ray crystallography2015

    • Author(s)
      H. Ogawa, A. Hirata, F. Cornelius, C. Toyoshima
    • Organizer
      日本生物物理学会第53回年会シンポジウム「輸送膜タンパク質のダイナミクス」
    • Place of Presentation
      金沢大学(石川県金沢市)
    • Year and Date
      2015-09-15
    • Description
      【発行確定】
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] イオンポンプ蛋白質の構造生物学とSPring-82015

    • Author(s)
      豊島 近
    • Organizer
      SPring-8シンポジウム2015
    • Place of Presentation
      九州大学(福岡市)
    • Year and Date
      2015-09-13
    • Description
      【発行確定】
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] New crystal structures of Ca^<2+>-and Na^+, K^+-ATPases2014

    • Author(s)
      C. Toyoshima
    • Organizer
      ASBMB Special Symposia Series, Na, K-ATPase and Related Transport ATPases
    • Place of Presentation
      De Werelt Conference Centre, Lunteren, オランダ
    • Year and Date
      2014-09-01
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] New crystal structures of Ca^<2+>-ATPase(SERCA) and Na^+, K^+-ATPases2014

    • Author(s)
      C. Toyoshima
    • Organizer
      Barcelona BioMed Conference, Transporters and other molecular machines
    • Place of Presentation
      the Sala Prat de Riba バルセロナ, スペイン
    • Year and Date
      2014-11-18
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] イオンポンプの構造生物学 : 全ての反射点の利用2013

    • Author(s)
      豊島 近
    • Organizer
      第13回日本蛋白質科学会年会
    • Place of Presentation
      とりぎん文化会館(鳥取市)
    • Year and Date
      2013-06-14
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Electron Crystallography of 3D Protein Crystals2013

    • Author(s)
      K. Yonekura, C. Toyoshima
    • Organizer
      Nagoya Symposium - Frontiers in Structural Physiology
    • Place of Presentation
      Nagoya University (Nagoya)
    • Data Source
      KAKENHI-PROJECT-24657111
  • [Presentation] Structural Understanding of ion Pumping by P-type ATPases.2013

    • Author(s)
      C. Toyoshima
    • Organizer
      Benzon Symposium No. 59
    • Place of Presentation
      Hotel Skt. Petriコペンハーゲンデンマーク
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] Do lipid bilayers followmovements of transmembrane helices? If so, to what extent2011

    • Author(s)
      C. Toyoshima
    • Organizer
      The EMBO Meeting
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2011-09-12
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] Do lipid bilayers follow movements of transmembrane helices? If so, to what extent?2011

    • Author(s)
      C.Toyoshima
    • Organizer
      The EMBO Meeting 2011
    • Place of Presentation
      Vienna, Austria(招待講演)
    • Year and Date
      2011-09-12
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] カルシウムATPaseの作動機構の理解と結晶構造解析2011

    • Author(s)
      豊島近
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2011-09-22
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] A structural view on ionpumping by Ca^<2+>-ATPase2010

    • Author(s)
      C. Toyoshima
    • Organizer
      FASEB SummerResearch Conferences, Transport ATPase : From molecules to maladies
    • Place of Presentation
      Snowmass, Colorado, USA(Key Note Lecture)
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] 放射光が明らかにするCa^<2+>ポンプのイオン輸送機構2010

    • Author(s)
      豊島近
    • Organizer
      ノーベル化学賞記念シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2010-03-06
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] A Structural view on ion pumping by Ca^<2+>-ATPase.2010

    • Author(s)
      C.Toyoshima
    • Organizer
      2010FASEB Summer Research Conferences
    • Place of Presentation
      Snowmass Village, Colorado USA
    • Year and Date
      2010-06-06
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] Structural aspects of cation pumping by P-type ATPase2009

    • Author(s)
      豊島近
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-29
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] 結晶構造から見たCa^<2+>-ATPaseのイオン輸送・エネルギー変換機構2009

    • Author(s)
      豊島近
    • Organizer
      日本生体エネルギー研究会第35回討論会
    • Place of Presentation
      旭川
    • Year and Date
      2009-12-19
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] How Ca2+ATPase pumps ionsacross the sarcoplasmic reticulummembrane2008

    • Author(s)
      C. Toyoshima
    • Organizer
      1st Sir Michael BerridgeLecture, 10th Symposium of the EuropeanCalcium Society
    • Place of Presentation
      Leuven, Belgium
    • Year and Date
      2008-09-17
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] How Ca^<2+>-ATPase Pump ion across the membrane2008

    • Author(s)
      C. Toyoshima
    • Organizer
      SPring-8 GPCR Symposium
    • Place of Presentation
      兵庫県・佐用郡
    • Year and Date
      2008-02-26
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] A Molecular Machine at Works : The Case of the Calcium Pump Protein2008

    • Author(s)
      C. Toyoshima
    • Organizer
      Maestro Lectures on Structure and Function of Membrane Proteins
    • Place of Presentation
      台湾・台北市
    • Year and Date
      2008-11-20
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] A Molecular Machine at Works2008

    • Author(s)
      C. Toyoshima
    • Organizer
      The Case of the Calcium Pump Protein
    • Place of Presentation
      Berkeley, USA
    • Year and Date
      2008-05-01
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] A Molecular Machine at Works : The case of the calcium pump protein2008

    • Author(s)
      C. Toyoshima
    • Organizer
      The Charles M. and Martha HITCHCOCK LECTURES
    • Place of Presentation
      アメリカ・バークレー
    • Year and Date
      2008-05-01
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] How Ca^<2+> ATPase pumps ions across the salcoplasmic reticulum membrane2008

    • Author(s)
      C. Toyoshima
    • Organizer
      第10回欧州カルシウム学会シンポジウム
    • Place of Presentation
      ベルギー・レーベン
    • Year and Date
      2008-09-17
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] Calcium, Proteins, Energy, and Life2008

    • Author(s)
      C. Toyoshima
    • Organizer
      Hitchcock Lecture
    • Place of Presentation
      Berkeley, California, USA
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] Crystallization of the calcium pump of skeletal muscle sarcoplasmic reticulum2008

    • Author(s)
      C. Toyoshima
    • Organizer
      第21回国際結晶学連合会議
    • Place of Presentation
      大阪市
    • Year and Date
      2008-08-29
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] How does Ca^<2+>-ATPase pumpions across the membrane2007

    • Author(s)
      C. Toyoshima
    • Organizer
      The LuigiSacconi Memorial Lecture in Chemistry
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2007-12-30
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] How does Ca^<2+>-ATPase pump ions across the membrane?2007

    • Author(s)
      C. Toyoshima
    • Organizer
      The Luigi Sacconi Memorial Lecture in Chemistry
    • Place of Presentation
      イタリア・フローレンス
    • Year and Date
      2007-10-30
    • Data Source
      KAKENHI-PROJECT-19002013
  • [Presentation] Structural study on the calcium ATPase: ion pumping mechanism and its regulation

    • Author(s)
      C. Toyoshima
    • Organizer
      The 1st NRPB International Symposium and Workshop for Membrane Proteins
    • Place of Presentation
      Academia Sinica, Taipei, Taiwan
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
  • [Presentation] How Na^+, K^+-ATPase select andpumps sodium across the membrane, Visualization of lipid bilayers in the crystals of calcium pump

    • Author(s)
      C. Toyoshima
    • Organizer
      2nd NTU Membrane Protein Weeks
    • Place of Presentation
      台湾大学台北市, 台湾
    • Year and Date
      2015-03-23 – 2015-03-25
    • Invited
    • Data Source
      KAKENHI-PROJECT-23000014
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  • 6.  KOUYAMA Tsutomu (30170210)
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  • 33.  HIGUCHI Yoshiki (90183574)
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  • 36.  KAMEYAMA Kimihiko (50224697)
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  • 73.  NABATA Hiroyuki
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  • 74.  SUZUKI Seiichi
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  • 79.  Karlish Steven
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  • 80.  安宅 光雄
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  • 81.  INESI Giusep
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  • 82.  NAKAZAWA Norihiko
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