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Sasaki Sei  佐々木 成

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佐々木 成  ササキ セイ

SASAKI Sei  佐々木 成

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Researcher Number 60170677
Other IDs
Affiliation (Current) 2022: 東京医科歯科大学, 高等研究院, 非常勤講師
Affiliation (based on the past Project Information) *help 2022: 東京医科歯科大学, 高等研究院, 非常勤講師
2016 – 2018: 明治薬科大学, 薬学部, 客員研究員
2017: 東京医科歯科大学, 大学院医歯学総合研究科, 名誉教授
2015: 明治薬科大学, 薬学部, 研究員
2012 – 2013: 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 … More
2010 – 2011: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2009: Tokyo Medical and Dental University, 医歯学総合研究科, 教授
2007 – 2008: Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 教授
2005 – 2006: 東京医科歯科大学, 大学院医歯学総合研究科, 教授
2002 – 2005: 東京医科歯科大学, 大学院・医歯学総合研究科, 教授
2004: Tokyo Medical and Dental University, Department of Nephrology, Professor, 医歯学総合大学院, 教授
2000 – 2001: Tokyo Medical and Dental University, Homeostasis Medicine and Nephrology, Associate Professor, 大学院・医歯学総合研究科, 助教授
1994 – 1999: 東京医科歯科大学, 医学部, 助教授
1989 – 1993: 東京医科歯科大学, 医学部, 講師
1987 – 1988: 東京医科歯科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Kidney internal medicine / Kidney internal medicine / 内科学一般 / Biological Sciences / Legal medicine
Except Principal Investigator
Kidney internal medicine / Biological Sciences / Hematology / Kidney internal medicine / Basic Section 53040:Nephrology-related
Keywords
Principal Investigator
アクアポリン / 水チャネル / 尿濃縮 / 腎臓 / HGF / 遺伝子改変マウス / チャネル / チャネル病 / 急性腎不全 / 嚢胞腎 … More / 水・電解質代謝学 / 輸送体 / PTH / Na / Cl / ET / メサンギウム細胞 / クロライドチャネル / ADH / Chloride channel / 遺伝子 / 細胞生物学 / 生理学 / 体内環境 / 細胞内ソーテング / Ets-1 / Wnt-4 / Activin / cyclin D / cyclin A / 細胞周期 / ES細胞 / 腎尿細管細胞 / 糸球体上皮細胞 / Wnt4 / aquaporin2 / nephrin / E2F1 / 幹細胞 / 尿細管細胞 / 上皮細胞 / Nephrin / 水輸送 / 尿崩症 / 膵炎 / リン脂質結合蛋白 / アクチン / トロポミオシン / 蛍光相関分光 / リト脂質結合蛋 / AKAP / 酵母two-hybrid法 / 細胞内輸送 / プロテオミクス / グリセロール / 膜蛋白質 / 塩分感受性高血圧 / 膜輸送体 / ケミカルライブラリー / リン酸化 / 高血圧 / AQP2 / WNKキナーゼ / アンギオテンシンII / SPAK / 小胞体 / トランスジェニックマウス / 免疫染色 / 尿細管 / 尿酸性化 / アルドステロン / H交換輸送 / HCO_3交換輸送 / NaーHCO_3共輸送 / アシド-シス / 水・電解質 / 電解質輸送 / ホルモン / 酸塩基平衡 / Nephron segments / Urinary acidification / Aldosterone / H exchange / HCO_3 / Na-HCO_3 cotransport / Acidosis / エンドセリン / 肝細胞増殖因子 / 腎炎 / Mesangial cells / Nephritis / Acute Renal Failure / クローニング / 膜タンパク / 腎輸送体 / Water channel / Aquaporin / Kidney / 利尿剤 / パゾプレシン / 腎臓集合尿細管 / 浮腫 / WATER CHANNEL / DIURETICS / VASOPRESSIN / KIDNEY COLLECTING DUCT / AQUAPORIN / 細胞内小胞 / ノックアウトマウス / water channel / aquaporin / channel disease / intracellular vesicle / knockout mice / 腎不全 / 糸球体増殖 / 細胞内イオン活性 / 微小電極 / 実験腎炎 / Chronic renal failure / Mesangial cell / Glomerular proliferation / Intracellular ion activities / Microelectrode / 水代謝 / エクソソーム / バソプレシン / 膜輸送 / 水透過性 / バイオマーカー / 水電解質 … More
Except Principal Investigator
水チャネル / AQP2 / アクアポリン / クロライドチャネル / 腎臓 / WNKキナーゼ / 尿崩症 / 集合尿細管 / Water channel / 分子生物学 / トランスポータ / AQP水チャネル / CLCクロライドチャネル / 塩分感受性高血圧 / 高血圧 / 膜輸送体 / ノックインマウス / Kidney / 尿濃縮 / 輸送体 / H-K-ATPase / バゾプレシン / 尿濃縮機構 / trafficking / AQP-2 / AQP-3 / CLC-K1 / CLC-K2 / CRE / GATA / AQP3 / AQP7 / AQP8 / 腎性尿崩症 / nitric oxide / イオンチャネル / カルシウムポンプ / 構造・機能相関 / クローニング / アルドステロン / 遺伝子改変マウス / AKAP / 酵母two-hybrid法 / 遺伝子組み換えマウス / 偽性低アルドステロン症II型 / claudin / Na-Cl共輸送体 / 蛋白複合体 / 細胞内局在 / エンドセリン / 急性腎不全 / 腎炎 / 受容体 / 抗体 / エンドセリン受容体 / 腎機能 / Endothelin / Renal failure / 集合管 / クロライドキャネル / バゾプレゥシン / ADH / 浮腫 / 脱水 / 腎尿細管 / kidney / Transportation / chloride channel / 腎集合管 / プロテインキナーゼA / プロテイン キナーゼA / Collecting duct / Protein kinase A / aquaporin-2 / water channel / vasopressin / collecting duct / urine concentration / exocytosis / プロモーター / Gリッチエレメント / 転写調節 / 核内タンパク / 遺伝子制御 / Promoter / purine-rich sequence / Nephrcgenic diabetes insipidus / チャネル病 / 電解質異常 / 体液制御 / チャネル / 水・電解質 / Membrane transport protein / Channelopathy / Chloride channel / Electrolyte abnormalities / WATER CHANNEL / CELL POLARITY / VASOPRESSIN / KIDNEY COLLECTING DUCT / AQUAPORIN / 糖質ステロイド / 細胞周期 / メサンジウム細胞 / C. elegans / glucocorticoid / cell cycle / mesangial cell / molecular biology / ソーティング / トランスジェニックマウス / 上皮輸送 / MDCK細胞 / 免疫沈降 / MPCK細胞 / 細胞内膜系 / ノックアウトマウス / クロライドチャンネル / AQP water channel / CLC chloride channel / sorting / transgenic mice / trans-epithelial transport / トラフィッキング / ソーティングシグナル / 小胞体 / ゴルジ装置 / sorting signal / nephrogenic diabetes insipidus / キナーゼ / メタボリックシンドローム / ケミカルライブラリー / 塩分ストレス / 次世代シークエンサー / 脂肪分化 / ストレス / 内科 / リン酸化酵素 / 創薬 / E3ユビキチンリガーゼ / シグナル伝達 / WNK キナーゼ / ナノディスク / 水チャネル阻害薬 / 水利尿薬 / 脳浮腫治療薬 Less
  • Research Projects

    (27 results)
  • Research Products

    (243 results)
  • Co-Researchers

    (53 People)
  •  Discovery of direct water channel inhibitors using aquaporin nanodisc technology

    • Principal Investigator
      野田 裕美
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53040:Nephrology-related
    • Research Institution
      Tokyo Medical and Dental University
  •  Mechanism and physiological role of urinary excretion of aquaporin-2Principal Investigator

    • Principal Investigator
      SASAKI SEI
    • Project Period (FY)
      2015 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Meiji Pharmaceutical University
  •  Salt stress-induced responses in health and disease: the role of WNK kinases and new therapeutic strategies

    • Principal Investigator
      UCIDA Shinichi
    • Project Period (FY)
      2013 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Role of aquaporins in endoplasmic reticulumPrincipal Investigator

    • Principal Investigator
      SASAKI SEI
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Novel strategy to regulate renal channels and transportersPrincipal Investigator

    • Principal Investigator
      SASAKI SEI
    • Project Period (FY)
      2010 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Identification of renal transportsomes by analyzing disease-causing mutants of transporters and their regulators.

    • Principal Investigator
      UCHIDA Shinichi
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Function and regulatory system of water transporting aquaporin channelsPrincipal Investigator

    • Principal Investigator
      SASAKI Sei
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Creative Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
  •  腎糸球体および尿細管細胞の再生医学の腎疾患治療への検討への応用Principal Investigator

    • Principal Investigator
      佐々木 成
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  アクアポリンの細胞内輸送・局在・機能分子メカニズムの研究Principal Investigator

    • Principal Investigator
      佐々木 成
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Studies on therapuetic strategy of renal channel diseases.Principal Investigator

    • Principal Investigator
      SASAKI Sei
    • Project Period (FY)
      2001 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Intracellular trafficking mechanisms of renal C1C and AQP channels

    • Principal Investigator
      UCHIDA Shinichi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  Intracellura traffic king of channel proteins and its regulation

    • Principal Investigator
      KUWAHARA Michio
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Functional expression, intracellular translocation, structure-function relationship of water channels in the collecting duct.

    • Principal Investigator
      KUWAHAWA Michio
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Molecular Cell Biological Studies of Kidney Membrane Transporter Diseases.

    • Principal Investigator
      MARUMO Fumiaki
    • Project Period (FY)
      1997 – 2000
    • Research Category
      Grant-in-Aid for Specially Promoted Research
    • Review Section
      Biological Sciences
    • Research Institution
      Tokyo Medical and Dental University
  •  STRUCTURE AND FUNCTION OF PEPTIDE SIGNALS FOR INTRACELLULAR LOGALIZATION OF AQP2 VASOPRESSIN WATER CHANNEL

    • Principal Investigator
      TOUJOU Naoko, 伏見 清秀
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University School of Medicine
  •  Transcriptional regulation of kidney-specific genesPrincipal Investigator

    • Principal Investigator
      INASE Naohiko, 佐々木 成
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Cloning and functional analysis of kidney-specifice gene

    • Principal Investigator
      KUWAHARA Michio
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  チャネルとトランスポータの構造・機能相関

    • Principal Investigator
      岡田 泰伸
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Okazaki National Research Institutes
  •  DEVELOPMENT OF WATER DIURETICS THAT INHIBIT WATER CHANNELPrincipal Investigator

    • Principal Investigator
      FUSHIMI Kiyohide, 佐々木 成
    • Project Period (FY)
      1995 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University School of Medicine
  •  Structural analysis and functional expression of vasopressin water channel

    • Principal Investigator
      FUSHIMI Kiyohide
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Urine concentrating mechanisms examined by molecular biology based techniques

    • Principal Investigator
      MARUMO Fumiaki
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Functional expression, intracellular translocation, structure-function relationship of water channels in the collecting duct.

    • Principal Investigator
      KUWAHARA Michio
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Cloning of kidney membrane transport proteins and characterization of its functionPrincipal Investigator

    • Principal Investigator
      SASAKI Sei
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Kidney internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Development of the drug which prevents the induction of acute renal failure and its clinical application

    • Principal Investigator
      MARUMO Fumiaki
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Hematology
    • Research Institution
      Tokyo Medical and Dental University
  •  Roles of new bioactine substances on renal disease. Basic and clinical studies.Principal Investigator

    • Principal Investigator
      SASAKI Sei
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Water and Electrolytes Transport in Reval Nephron SegmentsPrincipal Investigator

    • Principal Investigator
      SASAKI Sei
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      Tokyo Medical and Dental University
  •  Clarification of factors involved in progression of chronic renal failurePrincipal Investigator

    • Principal Investigator
      SASAKI Sei
    • Project Period (FY)
      1987 – 1988
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Legal medicine
    • Research Institution
      Tokyo Medical and Dental University

All 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 2001

All Journal Article Presentation Book Patent

  • [Book] Chapter 4. Regulation of Water Balance: Urine Concentration and Dilution. Diseases of the Kidney & Urinary Tract, Ninth Edition2012

    • Author(s)
      Noda Y, Sasaki S.
    • Publisher
      Lippincott Williams & Wilkins
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Book] Chapter 4. Regulation of Water Balance: Urine Concentration and Dilution. Diseases of the Kidney & Urinary Tract, Ninth Edition.2012

    • Author(s)
      Noda Y, Sasaki S.
    • Publisher
      Lippincott Williams & Wilkins
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Book] バゾプレシンのV2作用:AQP2調節と水代謝.バゾプレシンと受容体拮抗-その基礎と臨床-2011

    • Author(s)
      佐々木成
    • Publisher
      メディカルビュー社
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Book] 腎臓内科学2010

    • Author(s)
      佐々木成編集
    • Total Pages
      209
    • Publisher
      シュプリンガー・ジャパン
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Book] 体液とその組成ポケット輸液マニュアル(改訂版)2010

    • Author(s)
      佐々木成(北岡建樹編集)
    • Publisher
      羊土社
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Book] 水とアクアポリンの生物学2008

    • Author(s)
      佐々木成編
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] からだと水の事典2008

    • Author(s)
      佐々木成、石橋賢一編
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] 水と健康の関わり〜アクアポリンの働き〜. フードスタイル21 pp43-45, vol.12 No.72008

    • Author(s)
      佐々木成
    • Total Pages
      137
    • Publisher
      食品化学新聞社
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] 「水とアクアポリンの生物学」佐々木成編2008

    • Author(s)
      佐々木成
    • Total Pages
      206
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] アクアポリン-水はどうやって細胞膜を通るか-増補四訂版サイエンスビュー生物総合資料. Pp432008

    • Author(s)
      佐々木成
    • Total Pages
      304
    • Publisher
      実教出版
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] からだと水の事典. 体内水分量, pp7-8, アクアポリンの病気. pp64-70, 腎臓での水輸送の概要. pp179, 佐々木成, 石橋賢一編2008

    • Author(s)
      佐々木成
    • Total Pages
      357
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] からだと水の事典2008

    • Author(s)
      佐々木成, 石橋賢一, 編
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] からだと水の事典. 体内水分量. pp7-8, アクアポリンの病気. pp64-70, 腎臓での水輸送の概要. pp179, 佐々木成, 石橋賢一編2008

    • Author(s)
      佐々木成
    • Total Pages
      357
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] 「水とアクアポリンの生物学」佐々木成編2008

    • Author(s)
      佐々木成
    • Total Pages
      206
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] アクアポリン-水はどうやって細胞膜を通るか-増補四訂版サイエンスビュ-生物総合資料. pp432008

    • Author(s)
      佐々木成
    • Publisher
      実教出版
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] 水とアクアポリンの生物学2008

    • Author(s)
      佐々木成, 編
    • Total Pages
      216
    • Publisher
      中山書店
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] 水と健康の関わり〜アクアボリンの働き〜. フードスタイル21 pp43-45, vol. 12 No. 72008

    • Author(s)
      佐々木成
    • Publisher
      食品化学新聞社
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] ずみずしい体のしくみ2005

    • Author(s)
      佐々木成
    • Publisher
      クバプロ
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Book] みずみずしい体のしくみ2005

    • Author(s)
      佐々木 成
    • Publisher
      クバプロ
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] みずみずしい体のしくみ2005

    • Author(s)
      佐々木成, 編
    • Total Pages
      183
    • Publisher
      クバプロ
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Book] Fanconi症候群、シスチン尿症、Battre症候群、Gitelman症候群、家族性低リン血症性くる病.標準腎臓病学.2002

    • Author(s)
      佐々木 成
    • Publisher
      医学書院
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] AQP2 in human urine is predominantly localized to exosomes with preserved water channel activities.2018

    • Author(s)
      Miyazawa Yuko、Mikami Saki、Yamamoto Keiko、Sakai Masaki、Saito Tatsuya、Yamamoto Tadashi、Ishibashi Kenichi、Sasaki Sei
    • Journal Title

      Clin Exp Nephrol.

      Volume: 22 Pages: 782-788

    • DOI

      10.1007/s10157-018-1538-6

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-15K09302
  • [Journal Article] AKAPs-PKA disruptors increase AQP2 activity independently of vasopressin in a model of nephrognic diabetes insipidus.2018

    • Author(s)
      Ando Fumiaki、Mori Shuichi、Yui Naofumi、Morimoto Tetsuji、Nomura Naohiro、Sohara Eisei、Rai Tatemitsu、Sasaki Sei、Kondo Yoshiaki、Kagechika Hiroyuki、Uchida Shinichi
    • Journal Title

      Nature communications

      Volume: 9 Pages: 1-11

    • DOI

      10.1038/s41467-018-03771-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-18K08233, KAKENHI-PROJECT-18K19534, KAKENHI-PROJECT-18K15995, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-17H06656, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K09642
  • [Journal Article] Impaired degradation of medullary WNK4 in the kidneys of KLHL2 knockout mice2017

    • Author(s)
      Kasagi Y, Takahashi D, Aida T, Nishida H, Nomura N, Zeniya M, Mori T, Sasaki E, Ando F, Rai T, Uchida S, Sohara E.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 487 Pages: 368-374

    • DOI

      10.1016/j.bbrc.2017.04.068

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K07085, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-16K19478
  • [Journal Article] KLHL3 knockout mice reveal the physiological role of KLHL3 and the pathophysiology of PHAII caused by mutant KLHL3.2017

    • Author(s)
      Sasaki E, Susa K, Mori T, Isobe K, Araki Y, Inoue Y, Yoshizaki Y, Ando F, Mori Y, Mandai S, Zeniya M, Takahashi D, Nomura N, Rai T, Uchida S, Sohara E.
    • Journal Title

      Molecular and Cellular Biology

      Volume: 27 Pages: 1-13

    • DOI

      10.1128/mcb.00508-16

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15H06183, KAKENHI-PROJECT-16H06772, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-16K09642, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-17K16076
  • [Journal Article] Ser-261 phospho-regulation is involved in pS256 and pS269-mediated aquaporin-2 apical translocation2017

    • Author(s)
      Yui Naofumi、Ando Fumiaki、Sasaki Sei、Uchida Shinichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 490 Pages: 1039-1044

    • DOI

      10.1016/j.bbrc.2017.06.162

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Journal Article] Drug-Repositioning Screening for Keap1-Nrf2 Binding Inhibitors using Fluorescence Correlation Spectroscopy2017

    • Author(s)
      Yoshizaki Yuki、Mori Takayasu、Ishigami-Yuasa Mari、Kikuchi Eriko、Takahashi Daiei、Zeniya Moko、Nomura Naohiro、Mori Yutaro、Araki Yuya、Ando Fumiaki、Mandai Shintaro、Kasagi Yuri、Arai Yohei、Sasaki Emi、Yoshida Sayaka、Kagechika Hiroyuki、Rai Tatemitsu、Uchida Shinichi、Sohara Eisei
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 3945-3945

    • DOI

      10.1038/s41598-017-04233-3

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17K16076, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-16K15467
  • [Journal Article] Loop diuretics affect skeletal myoblast differentiation and exercise-induced muscle hypertrophy2017

    • Author(s)
      Mandai S, Furukawa S, Kodaka M, Hata Y, Mori T, Nomura N, Ando F, Mori Y, Takahashi D, Yoshizaki Y, Kasagi Y, Arai Y, Sasaki E, Yoshida S, Furuichi Y, Fujii NL, Sohara E, Rai T, Uchida S.
    • Journal Title

      Scientific Reports

      Volume: 7 Pages: 46369-46369

    • DOI

      10.1038/srep46369

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-26293061, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K16489, KAKENHI-PROJECT-16K15467, KAKENHI-PROJECT-16K09642
  • [Journal Article] Wnt5a induces renal AQP2 expression by activating calcineurin signalling pathway2016

    • Author(s)
      Ando F, Sohara E, Morimoto T, Yui N, Nomura N, Kikuchi E, Takahashi D, Mori T, Vandewalle A, Rai T, Sasaki S, Kondo Y, Uchida S.
    • Journal Title

      Nat Commun

      Volume: 7 Pages: 1-12

    • DOI

      10.1038/ncomms13636

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-16H05314, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K09286, KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-16K15467
  • [Journal Article] Disruption of membranes of extracellular vesicles is necessary for ELISA determination of urine AQP2: proof of disruption and epitopes of AQP2 antibodies:2016

    • Author(s)
      M. Nameta, Y. Saijo, Y. Ohmoto, K. Katsuragi, K. Yamamoto, T. Yamamoto, K. Ishibashi, S. Sasaki
    • Journal Title

      Int. J. Mol. Sci.

      Volume: 17

    • DOI

      10.3390/ijms17101634

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09301, KAKENHI-PROJECT-15K09302
  • [Journal Article] Alkali treatment stabilizes fluctuations of urine AQP2 values measured by ELISA2016

    • Author(s)
      S. Sasaki, Y. Saijo, Y. Ohmoto, F. Iwata, D. Koga, K. Katsuragi
    • Journal Title

      ClinExpNephrol

      Volume: 20 Pages: 450-455

    • DOI

      10.1007/s10157-015-1176-1

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Journal Article] Urinary excretion of the water channel aquaporin 2 correlated with the pharmacological effect of tolvaptan in cirrhotic patients with ascites2016

    • Author(s)
      Nakanishi H, Kurosaki M, Hosokawa T, Takahashi Y, Itakura J, Suzuki S, Yasui Y, Tamaki N, Nakakuki N, Takada H, Higuchi M, Komiyama Y, Yoshida T, Takaura K, Hayashi T, Kuwabara K, Sasaki S, Izumi N
    • Journal Title

      Gastroenterol. 2015 Nov 26. [Epub ahead of print]

      Volume: 印刷中

    • DOI

      10.1007/s00535-015-1143-3

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Journal Article] Impaired degradation of WNK by Akt and PKA phosphorylation of KLHL32015

    • Author(s)
      Yoshizaki Y, Mori Y, Tsuzaki Y, Mori T, Nomura N, Wakabayashi M, Takahashi D, Zeniya M, Kikuchi E, Araki Y, Ando F, Isobe K, Nishida H, Ohta A, Susa K, Inoue Y, Chiga M, Rai T, Sasaki S, Uchida S, Sohara E.
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 467 Pages: 229-234

    • DOI

      10.1016/j.bbrc.2015.09.184

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25461243, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-15K19445, KAKENHI-PROJECT-26860628, KAKENHI-PROJECT-26860629
  • [Journal Article] Discovery of novel SPAK inhibitors that block WNK kinase signaling to cation chloride transporters.2015

    • Author(s)
      Kikuchi E, Mori T, Zeniya M, Isobe K, Ishigami-Yuasa M, Fujii S, Kagechika H, Ishihara T, Mizushima T, Sasaki S, Sohara E, Rai T, Uchida S
    • Journal Title

      J. Am. Soc. Nephrol.

      Volume: 26 Pages: 1525-1536

    • DOI

      10.1681/asn.2014060560

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-26670428
  • [Journal Article] Generation and analysis of knock-in mice carrying pseudohypoaldosteronism type II-causing mutations in the cullin 3 gene2015

    • Author(s)
      Araki Y, Rai T, Sohara E, Mori T, Inoue Y, Isobe K, Kikuchi E, Ohta A, Sasaki S, Uchida S.
    • Journal Title

      Biol Open.

      Volume: 4 Pages: 1509-1517

    • DOI

      10.1242/bio.013276

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25461243, KAKENHI-PROJECT-26670428
  • [Journal Article] Kelch-like protein 2 mediates angiotensin II-with no lysine 3 signaling in the regulation of vascular tonus2015

    • Author(s)
      Zeniya M, Morimoto N, Takahashi D, Mori Y, Mori T, Ando F, Araki Y, Yoshizaki Y, Inoue Y, Isobe K, Nomura N, Oi K, Nishida H, Sasaki S, Sohara E, Rai T, Uchida S
    • Journal Title

      J Am Soc Nephrol.

      Volume: 26 Pages: 2129-2138

    • DOI

      10.1681/asn.2014070639

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-15K15327, KAKENHI-PROJECT-15K19446, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860628
  • [Journal Article] WNK4 is the major WNK kinase positively regulating NCC in the mouse kidney.2014

    • Author(s)
      Takahashi D, Mori T, Nomura N, Khan MZ, Araki Y, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biosci Rep.

      Volume: 34 (3) Pages: 195-205

    • DOI

      10.1042/bsr20140047

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428
  • [Journal Article] Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.2014

    • Author(s)
      Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S
    • Journal Title

      Hum Mol Genet.

      Volume: 23 (19) Pages: 5052-5060

    • DOI

      10.1093/hmg/ddu217

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428, KAKENHI-PROJECT-26860628, KAKENHI-PROJECT-221S0001
  • [Journal Article] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in an AQP11 Knockout Model2014

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
    • Journal Title

      J Am Soc Nephrol

      Volume: 25 Pages: 2789-2799

    • DOI

      10.1681/asn.2013060614

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24591243, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-26670428
  • [Journal Article] Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in AQP11 knockout mice.2014

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Xuefeng Su, Jing Zhou, Sasaki S, Uchida S.
    • Journal Title

      J. Am. Soc. Nephrol

      Volume: in press

    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Aberrant glycosylation and localization of polycystin-1 cause polycystic kidney in AQP11 knockout mice.2014

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Chiga M, Rai T, Ishibashi K, Horie S, Xuefeng Su, Jing Zhou, Sasaki S, Uchida S.
    • Journal Title

      J. Am. Soc. Nephrol

      Volume: in press

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Regulation of with-no-lysine kinase signaling by Kelch-like proteins.2014

    • Author(s)
      Uchida S, Sohara E, Rai T, Sasaki S
    • Journal Title

      Biol Cell.

      Volume: 106(2) Pages: 45-56

    • DOI

      10.1111/boc.201300069

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.2013

    • Author(s)
      Chu PY, Cheng CJ, Wu YC, Fang YW, Chau T, Uchida S, Sasaki S, Yang SS, Lin SH.
    • Journal Title

      PLoS One

      Volume: 8

    • DOI

      10.1371/journal.pone.0072969

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement2013

    • Author(s)
      Isobe K, Mori T, Asano T, Kawaguchi H, Nonoyama S, Kumagai N, Kamada F, Morimoto T, Hayashi M, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II2013

    • Author(s)
      Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Hypertension

      Volume: 62 Pages: 872-878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement.2013

    • Author(s)
      Isobe K, Mori T, Asano T, Kawaguchi H, Nonoyama S, Kumagai N, Kamada F, Morimoto T, Hayashi M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Journal Article] Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy2013

    • Author(s)
      Mori T, Kikuchi E, Watanabe Y, Fujii S, Ishigami-Yuasa M, Kagechika H, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem J

      Volume: 455 Pages: 339-45

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II.2013

    • Author(s)
      Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S
    • Journal Title

      Hypertension

      Volume: 62(5) Pages: 872-8

    • DOI

      10.1161/hypertensionaha.113.01543

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-23590319, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PUBLICLY-25136722, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25460350, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-25860670
  • [Journal Article] KLHL2 interacts with and ubiquitinates WNK kinases2013

    • Author(s)
      Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437 Pages: 457-462

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type caused by mutated Bsnd in mice2013

    • Author(s)
      Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Pages: 544-549

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] KLHL2 interacts with and ubiquitinates WNK kinases2013

    • Author(s)
      Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 437 Pages: 457-62

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] KLHL2 interacts with and ubiquitinates WNK kinases.2013

    • Author(s)
      Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 437(3) Pages: 457-62

    • DOI

      10.1016/j.bbrc.2013.06.104

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] Phosphorylation regulates NCC stability and transporter activity in vivo.2013

    • Author(s)
      Yang SS, Fang YW, Tseng MH, Chu PY, Yu IS, Wu HC, Lin SW, Chau T, Uchida S, Sasaki S, Lin YF, Sytwu HK, Lin SH.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 24 Pages: 1587-97

    • DOI

      10.1681/asn.2012070742

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] Hereditary nephrogenic diabetes insipidus in Japanese patients : analysis of 78 families and report of 22 new mutations in AVPR2 and AQP22013

    • Author(s)
      Sasaki S, Chiga M, Kikuchi E, Rai T, Uchida S
    • Journal Title

      Clin Exp Nephrol

      Volume: 17 Pages: 338-344

    • NAID

      10031184239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms2013

    • Author(s)
      Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 439 Pages: 30-34

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension2013

    • Author(s)
      Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 858-68

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Hereditary nephrogenic diabetes insipidus in Japanese patients: analysis of 78 families and report of 22 new mutations in AVPR2 and AQP2.2013

    • Author(s)
      Sasaki S, Chiga M, Kikuchi E, Rai T, Uchida S.
    • Journal Title

      Clin Exp Nephrol.

      Volume: 3 Pages: 338-44

    • DOI

      10.1007/s10157-012-0726-z

    • NAID

      10031184239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413
  • [Journal Article] Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type caused by mutated Bsnd in mice2013

    • Author(s)
      Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Pages: 544-49

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Immunolocalization and translocation of aquaporin-5 water channel in sweat glands2013

    • Author(s)
      Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S.
    • Journal Title

      J Dermatol Sci

      Volume: 70 Pages: 26-33

    • DOI

      10.1016/j.jdermsci.2013.01.013

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy2013

    • Author(s)
      Mori T, Kikuchi E, Watanabe Y, Fujii S, Ishigami-Yuasa M, Kagechika H, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem J

      Volume: 455 Pages: 339-345

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension2013

    • Author(s)
      Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Matsuo H, Murata T, Nomura S, Asano T, Kawaguchi H, Nonoyama S, Rai T, Sasaki S, Uchida S
    • Journal Title

      Cell Rep

      Volume: 3 Pages: 858-868

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Development of enzyme-linked immunosorbent assays for urinary thiazide-sensitive Na-Cl cotransporter (NCC) measurement2013

    • Author(s)
      Isobe K, Mori T, Asano T, Kawaguchi H, Nonoyama S, Kumagai N, Kamada F, Morimoto T, Hayashi M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 305

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Hereditary nephrogenic diabetes insipidus in Japanese patients : analysis of 78 families and report of 22 new mutations in AVPR2 and AQP22013

    • Author(s)
      Sasaki S, Chiga M, Kikuchi E, Rai T, Uchida S.
    • Journal Title

      Clin Exp Nephrol

      Volume: 17 Pages: 338-344

    • NAID

      10031184239

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Chemical library screening for WNK signalling inhibitors using fluorescence correlation spectroscopy2013

    • Author(s)
      Mori, T.; Kikuchi, E.; Watanabe, Y.; Fujii, S.; Ishigami-Yuasa, M.; Kagechika, H.; Sohara, E.; Rai, T.; Sasaki, S.; Uchida, S.
    • Journal Title

      Biochem J

      Volume: 455 Pages: 339-345

    • DOI

      10.1042/bj20130597

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22136013, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25460146, KAKENHI-PROJECT-25670406
  • [Journal Article] Treatment with 17-allylamino-17-demethoxygeldanamycin ameliorated symptoms of Bartter syndrome type IV caused by mutated Bsnd in mice.2013

    • Author(s)
      Nomura N, Kamiya K, Ikeda K, Yui N, Chiga M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 441 Pages: 544-49

    • DOI

      10.1016/j.bbrc.2013.10.129

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25293351, KAKENHI-PROJECT-25462653, KAKENHI-PROJECT-25670406, KAKENHI-PROJECT-25670721
  • [Journal Article] Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms.2013

    • Author(s)
      Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 439(1) Pages: 30-4

    • DOI

      10.1016/j.bbrc.2013.08.035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] Immunolocalization and translocation of aquaporin-5 water channel in sweat glands2013

    • Author(s)
      Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S
    • Journal Title

      J Dermatol Sci

      Volume: 70 Pages: 26-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Impaired KLHL3-mediated ubiquitination of WNK4 causes human hypertension2013

    • Author(s)
      Wakabayashi M
    • Journal Title

      Cell Reports.

      Volume: 28 Pages: 858-68

    • DOI

      10.1016/j.celrep.2013.02.024

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249047, KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-22390168, KAKENHI-PROJECT-22390213, KAKENHI-PROJECT-24659412, KAKENHI-PROJECT-24659413, KAKENHI-PROJECT-24790836, KAKENHI-PROJECT-25221306, KAKENHI-PROJECT-25670406
  • [Journal Article] Immunolocalization and translocation of aquaporin-5 water channel in sweat glands2013

    • Author(s)
      Inoue R, Sohara E, Rai T, Satoh T, Yokozeki H, Sasaki S, Uchida S.
    • Journal Title

      J Dermatol Sci

      Volume: 70 Pages: 26-33

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Dietary salt intake regulates WNK3-SPAK-NKCC1 phosphorylation cascade in mouse aorta through angiotensin II2013

    • Author(s)
      Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S
    • Journal Title

      Hypertension

      Volume: 62 Pages: 872-878

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Decrease of WNK4 ubiquitination by disease-causing mutations of KLHL3 through different molecular mechanisms2013

    • Author(s)
      Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 439 Pages: 30-4

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination2012

    • Author(s)
      Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 425 Pages: 456-461

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Does a β 2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney?2012

    • Author(s)
      Uchida S, Chiga M, Sohara E, Rai T, Sasaki S
    • Journal Title

      Nat. Med

      Volume: 18 Pages: 1324-1325

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Aquaporin 2: from its discovery to molecular structure and medical implications.2012

    • Author(s)
      Sasaki S.
    • Journal Title

      Mol Aspects Med.

      Volume: 33 Pages: 535-546

    • DOI

      10.1016/j.mam.2012.03.004

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413
  • [Journal Article] Does aβ2-adrenergic receptor-WNK4-Na-Cl co-transporter signal cascade exist in the in vivo kidney?2012

    • Author(s)
      Uchida S, Chiga M, Sohara E, Rai T, Sasaki S.
    • Journal Title

      Nat. Med

      Volume: 18 Pages: 1324-5

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice2012

    • Author(s)
      Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Hypertension

      Volume: 60 Pages: 981-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo2012

    • Author(s)
      Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S.
    • Journal Title

      Biol.Open

      Volume: 1 Pages: 120-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Daily variance of urinary excretion of AQP2 determined by sandwich ELISA method.2012

    • Author(s)
      Sasaki S
    • Journal Title

      Clin. Exp. Nephrol.

      Volume: (published online) Pages: 406-410

    • DOI

      10.1007/s10157-011-0574-2

    • NAID

      10030808445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032, KAKENHI-PROJECT-24659413
  • [Journal Article] A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo2012

    • Author(s)
      Oi K, Sohara E, Rai T, Misawa M, Chiga M, Alessi DR, Sasaki S, Uchida S
    • Journal Title

      Biol.Open

      Volume: 1 Pages: 120-127

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone2012

    • Author(s)
      Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 427 Pages: 743-747

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice2012

    • Author(s)
      Nishida H, Sohara E, Nomura N, Chiga M, Alessi DR, Rai T, Sasaki S, Uchida S
    • Journal Title

      Hypertension

      Volume: 60 Pages: 981-990

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels2012

    • Author(s)
      Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S
    • Journal Title

      Clin. Exp. Nephrol

      Volume: 16 Pages: 530-538

    • NAID

      10031058026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels2012

    • Author(s)
      Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.
    • Journal Title

      Clin Exp. Nephrol

      Volume: 16 Pages: 530-8

    • NAID

      10031058026

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] WNK-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone2012

    • Author(s)
      Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 427 Pages: 743-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Phosphorylation of Na-Cl cotransporter by OSR1 and SPAK kinases regulates its ubiquitination2012

    • Author(s)
      Hossain Khan MZ, Sohara E, Ohta A, Chiga M, Inoue Y, Isobe K, Wakabayashi M, Oi K, Rai T, Sasaki S, Uchida S.
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 425 Pages: 456-61

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Journal Article] Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney2011

    • Author(s)
      Sohara E, Rai T, Yang SS, Ohta A, Naito S, Chiga M, Nomura N, Lin SH, Vandewalle A, Ohta E, Sasaki S, Uchida S
    • Journal Title

      PLoS One

      Volume: 6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade2011

    • Author(s)
      Chiga M, Rafiqi FH, Alessi DR, Sohara E, Ohta A, Rai T, Sasaki S, Uchida S
    • Journal Title

      J. Cell Sci

      Volume: 124 Pages: 1391-1395

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Immunolocalization of WNK4 in mouse kidney2011

    • Author(s)
      Ohno M, Uchida K, Ohashi T, Nitta K, Ohta A, Chiga M, Sasaki S, Uchida S
    • Journal Title

      Histochem. Cell Biol

      Volume: 136 Pages: 25-35

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Regulation of WNK1 kinase by extracellular potassium2011

    • Author(s)
      Naito S, Ohta A, Sohara E, Ohta E, Rai T, Sasaki S, Uchida S
    • Journal Title

      Clin. Exp. Nephrol

      Volume: 15 Pages: 195-202

    • NAID

      10029005115

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Generation and analyses of R8L barttin knockin mouse2011

    • Author(s)
      Nomura N, Tajima M, Sugawara N, Morimoto T, Kondo Y, Ohno M, Uchida K, Mutig K, Bachmann S, Soleimani M, Ohta E, Ohta A, Sohara E, Okado T, Rai T, Jentsch TJ, Sasaki S, Uchida S
    • Journal Title

      Am. J. Physiol. Renal. Physiol

      Volume: 301

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Effect of angiotensin II on the WNK-OSR1/SPAK-NCC phosphorylation cascade in cultured mpkDCT cells and in vivo mouse kidney2010

    • Author(s)
      Talati G, Ohta A, Rai T, Sohara E, Naito S, Vandewalle A, Sasaki S, Uchida S
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 393 Pages: 844-848

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Mechanisms for hypercalciuria in pseudohypoaldosteronism type II-causing WNK4 knock-in mice2010

    • Author(s)
      Yang SS, Hsu YJ, Chiga M, Rai T, Sasaki S, Uchida S, Lin SH
    • Journal Title

      Endocrinology

      Volume: 151 Pages: 1829-1836

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] Phosphorylation of aquaporin-2 regulates its water permeability2010

    • Author(s)
      Eto K, Noda Y, Horikawa S, Uchida S, Sasaki S
    • Journal Title

      J. Biol. Chem

      Volume: 285 Pages: 40777-40784

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Journal Article] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells2009

    • Author(s)
      Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S.
    • Journal Title

      Am.J.Physiol.Cell Physiol. 297

      Pages: 1389-1396

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis2009

    • Author(s)
      Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T.
    • Journal Title

      Am.J.Physiol.Cell Physiol. 297

      Pages: 1368-78

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure2009

    • Author(s)
      Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.
    • Journal Title

      Hum.Mol.Genet. 18

      Pages: 3978-86

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis.2009

    • Author(s)
      Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T.
    • Journal Title

      Am. J. Physiol. Cell Physiol. 297

      Pages: 1368-78

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells.2009

    • Author(s)
      Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, Uchida S.
    • Journal Title

      Am. J. Physiol. Cell Physiol. 297

      Pages: 1389-1396

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.2009

    • Author(s)
      Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, Uchida S.
    • Journal Title

      Hum. Mol. Genet. 18

      Pages: 3978-86

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Is oxytocin a player in antidiuresis?2008

    • Author(s)
      Sasaki S
    • Journal Title

      J Am Soc Nephrol. 19

      Pages: 225-232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.2008

    • Author(s)
      Chiga M, Rai T, Yang S-S, Ohta A, Takizawa T, Sasaki S, Uchida S.
    • Journal Title

      Kidney Int. 74

      Pages: 1403-1409

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Is oxytocin a player in antidiuresis?2008

    • Author(s)
      Sasaki S
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 189-190

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking.2008

    • Author(s)
      Noda Y, Horikawa S, Kanda E, Yamashita M, Meng H, Eto E, Li Y, Kuwahara M, Hirai K, Pack C, Kinjo M, Okabe S, Sasaki S.
    • Journal Title

      J. Cell Biol. 182

      Pages: 587-601

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Introduction for special issue for aquaporin: Expanding the world of aquaporins.2008

    • Author(s)
      Sasaki S
    • Journal Title

      Pflugers Archiv (印刷中)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Is oxytocin a player in antidiuresis?2008

    • Author(s)
      Sasaki S
    • Journal Title

      J Am Soc Nephrol 19

      Pages: 225-232

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking2008

    • Author(s)
      Noda Y, Horikawa S, Kanda E, Yamashita M, Meng H, Eto E, Li Y, Kuwahara M, Hirai K, Pack C, Kinjo M, Okabe S, Sasaki S.
    • Journal Title

      J.Cell Biol. 182

      Pages: 587-601

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Invited Review : Introduction for special issue for aquaporin. Expanding the world of aquaporin : new members and new functions.2008

    • Author(s)
      SaSaki S
    • Journal Title

      Pflugers Arch 456

      Pages: 647-649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Invited Review: Introduction for special issue for aquaporin. Expanding the world of aquaporins: new members and new functions.2008

    • Author(s)
      Sasaki S
    • Journal Title

      Pflugers Arch 456

      Pages: 647-649

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4 D561A/+ knock-in mouse model.2007

    • Author(s)
      Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin S-H, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.
    • Journal Title

      Cell Metab 5

      Pages: 331-344

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Molecular pathogenesis of pseudohypoaldosteronism type II : generation and analysis of a Wnk4 D561A/+ knock-in mouse model2007

    • Author(s)
      Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin S-H, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.
    • Journal Title

      Cell Metab 5

      Pages: 331-344

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Aquaporin-2 protein dynamics within the cell.2007

    • Author(s)
      Sasaki S., et. al.
    • Journal Title

      Curr Opin Nephrol Hypertens 16

      Pages: 348-352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation2006

    • Author(s)
      Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, Uchida S.
    • Journal Title

      Proc Natl Acad Sci USA 103

      Pages: 14217-14222

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers.2006

    • Author(s)
      Suzuki T, Rai T, Hayama A, Sohara E, Suda S, Itoh T, Sasaki S, Uchida S
    • Journal Title

      J Cell Physiol 206

      Pages: 792-798

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] The polarized trafficking of the aquaporin-3 water channel is mediated by an N-Terminal Sorting Signal.2006

    • Author(s)
      Rai T, Sasaki S, Uchida S.
    • Journal Title

      Am J Physiol Cell Physiol. 290(1)

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation.2006

    • Author(s)
      Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, Uchida S.
    • Journal Title

      Proc Natl Acad Sci U S A. 103

      Pages: 14217-14222

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Regulation of aquaporin-2 trafficking and its binding protein complex.2006

    • Author(s)
      Noda Y, Sasaki S
    • Journal Title

      Biochim Biophys Acta 1758

      Pages: 1117-1125

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] The polarized trafficking of the aquaporin-3 water channel is mediated by an N-Terminal Sorting Signal2006

    • Author(s)
      Rai T, Sasaki S, Uchida S.
    • Journal Title

      Am J Physiol Cell Physiol. 290(1)

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Nephrologists Sans Frontieres : Chronic kidney disease in Japan.2006

    • Author(s)
      Sasaki S
    • Journal Title

      Kidney Int 69

      Pages: 1485-1486

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] The polarized trafficking of the aquaporin-3 water channel is mediated by an N-terminal sorting signal.2006

    • Author(s)
      Rai T, Sasaki S, Uchida S
    • Journal Title

      Am J Physiol Cell Physiol 290(1)

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.2005

    • Author(s)
      Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S.
    • Journal Title

      Am J Physiol Renal Physiol. 289(6)

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Regulation of apical localization of the thiazide-sensitive NaCl cotransporter by WNK4 in polarized epithelial cells.2005

    • Author(s)
      Yang S-S, Yamauchi K, Rai T, Hayama A, Sohara E, Suzuki T, Itoh T, Suda S, Sasaki S, Uchida S
    • Journal Title

      Biochem Biophys Res Com 330

      Pages: 410-414

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Progressive adipocyte hypertrophy in aquaporin-7 deficient mice: Adipocyte glycerol permeability as a novel regulator of fat accumulation.2005

    • Author(s)
      Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS.
    • Journal Title

      J Biol Chem. 280(16)

      Pages: 15493-15496

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Defective water and glycerol transportin the proximal tubules of AQP7 knockout mice.2005

    • Author(s)
      Sohara E, Rai T, Miyazaki J, Ikawa M, Okabe M, Verkman A.S., Sasaki S, Uchida S
    • Journal Title

      Am J Physiol Renal Physiol 289

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Identification of a multiprotein "motor" complex binding to water channel aquaporin-22005

    • Author(s)
      Noda Y, Horikawa S, Katayama Y, Sasaki S.
    • Journal Title

      Biochem Biophys Res Commun. 330

      Pages: 1041-1047

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule.2005

    • Author(s)
      Morishita Y, Matsuzaki T, Hara-Chikuma M, Ando A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K.
    • Journal Title

      Mol Cell Biol. 25

      Pages: 7770-7779

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Disruption of aquaporin-11 produces polycystic kidneys following vacuolization of the proximal tubule2005

    • Author(s)
      Morishita Y, Matsuzaki T, Hara-Chikuma M, Ando A, Shimono M, Matsuki A, Kobayashi K, Ikeda M, Yamamoto T, Verkman A, Kusano E, Ookawara S, Takata K, Sasaki S, Ishibashi K.
    • Journal Title

      Mol Cell Biol. 25

      Pages: 7770-7779

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Identification of a multiprotein "motor" complex binding to water channel aquaporin-2.2005

    • Author(s)
      Noda Y, Horikawa S, Katayama Y, Sasaki S.
    • Journal Title

      Biochem Biophys Res Commun. 330

      Pages: 1041-1047

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Progressive adipocyte hypertrophy in aquaporin-7 deficient mice : Adipocyte glycerol permeability as a novel regulator of fat accumulation2005

    • Author(s)
      Hara-Chikuma M, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S, Uchida S, Verkman AS.
    • Journal Title

      J Biol Chem. 280(16)

      Pages: 15493-15496

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] ClC-3 chloride channels facilitate endosomal acidification and chloride accumulation.2005

    • Author(s)
      Hara-Chikuma M, Yang B, Sonawane ND, Sasaki S, Uchida S, Verkman AS
    • Journal Title

      J Biol Chem 280

      Pages: 1241-1247

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Function of chloride channels in the kidney.2005

    • Author(s)
      Uchida S, Sasaki S
    • Journal Title

      Annu Rev Physiol 67

      Pages: 759-778

    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice2005

    • Author(s)
      Sohara E, Rai T, Miyazaki J, Verkman AS, Sasaki S, Uchida S.
    • Journal Title

      Am J Physiol Renal Physiol. 289(6)

    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Journal Article] Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2.2005

    • Author(s)
      Uchida S, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S
    • Journal Title

      Mol Cell Biol 25

      Pages: 7357-7363

    • Data Source
      KAKENHI-PROJECT-17081009
  • [Journal Article] Aquaporin-2 is retrieved to the apical storage compartment via early endosomes and phosphatidyl nositol 3-kinase-dependent pathway.2004

    • Author(s)
      Tajika Y, Matsuzaki T, Suzuki T, Aoki T, Hagiwara H, Kuwahara M, Sasaki S, Takata K.
    • Journal Title

      Endcrinology 145

      Pages: 4375-4383

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Nephrogenic diabetes insipidus : update of genetic and clinical aspects2004

    • Author(s)
      Sasaki S.
    • Journal Title

      Nephrol Dial Transpl 19

      Pages: 1351-1353

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Molecular mechanism of water channel aquaporin-2 trafficking.2004

    • Author(s)
      Noda Y, Sasaki S
    • Journal Title

      J Pharmacol Sci 96

      Pages: 249-254

    • Data Source
      KAKENHI-PROJECT-13137203
  • [Journal Article] Nephrogenic diabetes insipidus : update of genetic and clinical aspects.2004

    • Author(s)
      Sasaki S
    • Journal Title

      Nephrol Dial Transpl 19

      Pages: 1351-1353

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] diabetes insipidus : update of genetic and clinical aspects.2004

    • Author(s)
      Sasaki S
    • Journal Title

      Nephrol Dial Transpl 19

      Pages: 1351-1353

    • Data Source
      KAKENHI-PROJECT-13137203
  • [Journal Article] Molecular mechanism of water channel aquaporin-2 trafficking.2004

    • Author(s)
      Noda Y, Sasaki S.
    • Journal Title

      J Pharmacol Sci 96

      Pages: 249-254

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] ClC-3-independent, PKC-dependent activity of volume-sensitive Cl- channel in mouse ventricular cardiomyocytes.2004

    • Author(s)
      Gong WQ, Uchida S, Sasaki S et al.
    • Journal Title

      Cell Physiol Biochem 14

      Pages: 213-224

    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.2004

    • Author(s)
      Yamauchi K, Rai T, Kobayashi K, Sohara E, Suzuki T, Itoh T, Suda S, Hayama A, Sasaki S, Uchida S.
    • Journal Title

      Proc Natl Acad Sci USA. 101

      Pages: 4690-4694

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Nephrogenic diabetes insipidus : update of genetic and clinical aspects.2004

    • Author(s)
      Sasaki S.
    • Journal Title

      Nephrol Dial Transpl 19(6)

      Pages: 1351-1353

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1.2004

    • Author(s)
      Noda Y, Sasaki S et al.
    • Journal Title

      FEBS lett 68

      Pages: 139-145

    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Water channel aquaporin-2 directly binds to actin.2004

    • Author(s)
      Noda Y, Horikawa S, Katayama Y, Sasaki S.
    • Journal Title

      Biochem Bioph Res Com 322

      Pages: 740-745

    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Water channel aquaporin-2 directly binds to actin.2004

    • Author(s)
      Noda Y, Horikawa S, Katayama Y, Sasaki S.
    • Journal Title

      Biochem Biophys Res Commun 322

      Pages: 740-745

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Disease-causing mutant WNK4 increases paracellular chloride permeability and phosphorylates claudins.:, 2004.2004

    • Author(s)
      Yamauchi K, Uchida S, Sasaki S, et al.
    • Journal Title

      Proc Natl Acad Sci U S A. 101

      Pages: 4690-4694

    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Molecular mechanism of water channel aquaporin-2 trafficking.2004

    • Author(s)
      Noda Y, Sasaki S
    • Journal Title

      J Pharmacol Sci 96

      Pages: 249-254

    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1.2004

    • Author(s)
      Noda Y, Horikawa S, Furukawa T, Hirai K, Katayama Y, Asai T, Kuwahara M, Katagiri K, Kinashi T, Hattori M, Minato N, Sasaki S.
    • Journal Title

      FEBS lett 568

      Pages: 139-145

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Nephrogenic diabetes insipidus : update of genetic and clinical aspects.2004

    • Author(s)
      Sasaki S
    • Journal Title

      Nephrol Dial Transpl 19(6)

      Pages: 1351-1353

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12144204
  • [Journal Article] Vasopressin-independent renal urinary concentration : Increased rBSC1 and enhanced countercurrent multiplication.2003

    • Author(s)
      Michimata M, Mizukami K, Suzuki M, Kazama I, Nakamura Y, Suzuki K, Yanagisawa T, Imai Y, Sasaki S, Matsubara M.
    • Journal Title

      Kidney Int 64

      Pages: 933-938

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Pathogenesis of nephrogenic diabetes insipidus by aquaporin-2 C-terminus mutations.2003

    • Author(s)
      Asai T, Kuwahara M, Kurihara H, Sakai T, Terada Y, Marumo F, Sasaki S.
    • Journal Title

      Kidney Int 64

      Pages: 2-10

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Kidney-specific chloride channel, OmClC-K, predominantly expressed in the diluting segment of freshwater-adapted tilapia kidney.2002

    • Author(s)
      Miyazaki H, Kaneko T, Uchida S, Sasaki S, Takei Y.
    • Journal Title

      Proc Natl Acad Sci USA 99(24)

      Pages: 15782-15787

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Cloning and identification of a new member of water channel (AQP10) as an aquaglyceroporin.2002

    • Author(s)
      Ishibashi K, Morinaga T, Kuwahara M, Sasaki S, Imai M.
    • Journal Title

      Biochim Biophys Acta 1576

      Pages: 335-340

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear.2002

    • Author(s)
      Kobayashi K, Uchida S, Okamura HO, Marumo F, Sasaki S.
    • Journal Title

      J Am Soc Nephrol 13(8)

      Pages: 1992-1998

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Two novel aquaporin-2 mutations responsible for congenital nephrogenic diabetes insipidus in Chinese families.2002

    • Author(s)
      Lin S-H, Bichet DG, Sasaki S, Kuwahara M, Arthus M-F, Lonergan M, Lin Y-F.
    • Journal Title

      J Clin Endocrinol Metab 87

      Pages: 2694-2700

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Analysis of NaCl transport in thin ascending limb of Henle's loop in CLC-K1 null mice.2002

    • Author(s)
      Liu W, Morimoto T, Kondo Y, Iinuma K, Uchida S, Sasaki S, Marumo F, Imai M.
    • Journal Title

      Am J Physiol Renal P282(3)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] CLC-3 deficiency leads to phenotypes similar to human neuronal ceroid lipofuscinosis.2002

    • Author(s)
      Yoshikawa M, Uchida S, Ezaki J, Rai T, Hayama A, Kobayashi K, Kida Y, Noda M, Koike M, Uchiyama Y, Marumo F, Kominami E, Sasaki S.
    • Journal Title

      Genes Cells 7(6)

      Pages: 597-605

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Role of aquaporin-2 gene expression in hyponatremic rats with chronic vasopressin-induced antiduresis2001

    • Author(s)
      Saito T, Higashiyama M, Nagasaka S, Sasaki S, Saito T, Ishikawa S.
    • Journal Title

      Kidney Int 60

      Pages: 1266-1276

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Two Sporadic Cases of Liddle's Syndrome Caused by De Novo ENaC Mutations.2001

    • Author(s)
      Yamashita Y, Koga M, Takeda Y, Enomoto N, Uchida S, Hashimoto K, Yamano S, Dohi K, Marumo F, Sasaki S.
    • Journal Title

      Am J Kidney Dis 37

      Pages: 499-504

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Intrarenal and cellular localization of CLC-K2 protein in the mouse kidney.2001

    • Author(s)
      Kobayashi K, Uchida S, Mizutani S, Sasaki S, Marumo F.
    • Journal Title

      J Am Soc Nephrol 12

      Pages: 1327-1334

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Impaired solute accumulation in inner medulla of Clcnk1-/-mice kidney.2001

    • Author(s)
      Akizuki N, Uchida S, Sasaki S, Marumo F.
    • Journal Title

      Am J Physiol 280

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Expression of aquaporins 7 and 8 in the developing rat testis.2001

    • Author(s)
      Kageyama Y, Ishibashi K, Hayashi T, Xia G, Sasaki S, Kihara K.
    • Journal Title

      Andrologia 33

      Pages: 165-169

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Journal Article] Three families with autosomal dominant nephrogenic diabetes insipidus caused by aquaporin-2 mutations in the C-terminus.2001

    • Author(s)
      Kuwahara M, Iwai K, Ooeda T, Igarashi T, Ogawa E, Katsushima Y, Shinbo I, Uchida S, Terada Y, Arthus MF, Lonergan M, Fujiwara TM, Bichet DG, Marumo F, Sasaki S.
    • Journal Title

      Am J Hum Genet 69

      Pages: 738-748

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-13307030
  • [Patent] タンパク質を含む生体試料の前処理方法2011

    • Inventor(s)
      佐々木成、大本安一、森豊樹、岩田房子、村口正宏
    • Industrial Property Rights Holder
      大塚製薬株式会社、国立大学法人東京医科歯科大学
    • Industrial Property Number
      2011-176272
    • Filing Date
      2011-08-11
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Phosphorylation of Ser261 and dephosphorylation of Ser269 is important for urinary excretion of AQP2.2018

    • Author(s)
      Sasaki S, Sakai M, Mizumura H, Matsumoto T, Noda Y, Yui N, Ishibashi K.
    • Organizer
      51th Annual Meeting of American Society of Nephrology.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Proteomics and water channel function of AQP2-rich extracellular vesicles in human urine.2017

    • Author(s)
      MiyazawaY, Mikami S, Sakai M, Saito T, Ishibashi K, Sasaki S
    • Organizer
      50th Annual Meeting of American Society of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] KLHL2は腎臓でWNK4蛋白の分解を行う2017

    • Author(s)
      笠木祐里,蘇原映誠,相田知海,高橋大栄,西田秀範,野村尚弘,銭谷慕子,森崇寧,佐々木絵美,安藤史顕,頼建光,内田信一
    • Organizer
      第60回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Generation and Analysis of KLHL2 Knockout Mice2017

    • Author(s)
      Yuri Kasagi, Daiei Takahashi, Tomomi Aida, Hidenori Nishida, Naohiro Nomura, Moko Zeniya, Takayasu Mori, Emi Sasaki, Fumiaki Ando, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
    • Organizer
      The 50th Annual Meeting of the American Society of Nephrology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] 変異CUL3によるPHAIIの発症にはKLHL3の発現低下が関与する2017

    • Author(s)
      吉田紗矢香, 蘇原映誠, 荒木雄也, 笠木祐里, 佐々木絵美, 須佐紘一郎, 森崇寧, 井上佑一, 磯部清志, 頼建光, 内田信一
    • Organizer
      第60回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] 尿中AQP2の基礎的臨床的検討2017

    • Author(s)
      三上早紀、宮澤優子、斉藤達也、田中靖子、佐藤恵子、野田裕美、山本恵子、山本格、石橋賢一、佐々木成
    • Organizer
      第60回日本腎臓学会学術総会
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Functional and proteinous characterization of AQP2-rich extracellular vesicles in human urine.2017

    • Author(s)
      Mikami S, MiyazawaY, Sakai M, Saito T, Tanaka Y, Yamamoto K, Yamamoto T, Ishibashi K, Sasaki S
    • Organizer
      54th ERA-EDTA Congress
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Decreased protein expression of KLHL3 is involved in the pathogenesis of PHAII caused by CUL3 mutation in vivo.2017

    • Author(s)
      Sayaka Yoshida, Yuya Araki, Takayasu Mori, Emi Sasaki, Yuri Kasagi, Kiyoshi Isobe, Koichiro Susa, Yuichi Inoue, Tatemitsu Rai, Shinichi Uchida,Eisei Sohara.
    • Organizer
      The 51th Annual Meeting of American Society of Nephrology.
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Urine AQP2 Comes from Exosome Pathway and Represents a Long-term Regulation of Vasopressin2016

    • Author(s)
      Sei Sasaki1, Yoko Saijo, Yasukazu Ohmoto, Kiyonori Katsuragi, Kenichi Ishibashi, Keiko Yamamoto, Tadashi Yamamoto
    • Organizer
      2016年アメリカ腎臓学会
    • Place of Presentation
      マコーミック会議場(シカゴ)
    • Year and Date
      2016-11-18
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Generation and analysis of KLHL3 knockout mice2016

    • Author(s)
      Emi Sasaki, Koichiro Susa, Takayasu Mori, Kiyoshi Isobe, Yuya Araki, Yuichi Inoue, Tatemitsu Rai, Shinichi Uchida, Eisei Sohara
    • Organizer
      Annual Meeting of the American Society of Nephrology, Kidney Week 2016
    • Place of Presentation
      Chicago(米国)
    • Year and Date
      2016-11-17
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] 尿中AQP2排泄機序の基礎的検討:エクソソームとトラフィッキング2016

    • Author(s)
      酒井柾、高橋由衣、田中靖子、石橋賢一、佐々木成、 行田正晃、山本恵子、山本格
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2016-06-18
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Urine Aquaporin-2: Improvement in ELISA Measurements by alkali pre-treatment and mechanisms of the secretion2015

    • Author(s)
      Sei Sasaki, Saijo Y, Ohmoto Y, Iwata F, Koga D, Shimada T, Sakai M, Takahashi Y, Tanaka Y, Ishibashi K, Katsuragi K
    • Organizer
      アメリカ腎臓学会
    • Place of Presentation
      サンディエゴ (アメリカ)
    • Year and Date
      2015-11-07
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Cross-talk between bedside and bench of AQP22015

    • Author(s)
      Sei Sasaki
    • Organizer
      Second World Congress on Water Channel Proteins
    • Place of Presentation
      クルジェナポカ (ルーマニア)
    • Year and Date
      2015-05-08
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09301
  • [Presentation] Low salt intake decreased transcription and protein level of KLHL3 in mouse kidney2013

    • Author(s)
      Susa K, Sohara E, Zeniya M, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Ser-261 phosphorylation is an endocytic signal of aquaporin-2 water channel.2013

    • Author(s)
      Yui N, Uchida S, Sasaki S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in AQP11-Knockout Mice2013

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Impaired KLHL3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases-NaCl cotransporter (NCC) signaling and causes hypertension.2013

    • Author(s)
      Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Clinical Significance of Urinary Thiazide-Sensitive Na-Cl Cotransporter (NCC) Measurement by Newly Development Enzyme-Linked Immunosorbent Assays2013

    • Author(s)
      Isobe K, Mori T, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Chemical library screening for WNK signaling inhibitors by using fluorescent correlation spectroscopy2013

    • Author(s)
      Mori T, Eriko K, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Impaired KLHL3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases-NaCl cotransporter (NCC) signaling and causes hypertension2013

    • Author(s)
      Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Clinical Significance of Urinary Thiazide-Sensitive Na-Cl Cotransporter (NCC) Measurement by Newly Development Enzyme-Linked Immunosorbent Assays.2013

    • Author(s)
      Isobe K, Mori T, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Ser-261 phosphorylation is an endocytic signal of aquaporin-2 water channel2013

    • Author(s)
      Yui N, Uchida S, Sasaki S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta, USA
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] WNK3 Regulates Blood Pressure Through the Regulation of Vascular OSR1/SPAK-NKCC1 Phosphorylation Cascade2013

    • Author(s)
      Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Clinical Significance of Urinary Thiazide-Sensitive Na-Cl Cotransporter (NCC) Measurement by Newly Development Enzyme-Linked Immunosorbent Assays2013

    • Author(s)
      Isobe K, Mori T, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Impaired KLHL3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases-NaCl cotransporter (NCC) signaling and causes hypertension.2013

    • Author(s)
      Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Ser-261 phosphorylation is an endocytic signal of aquaporin-2 water channel2013

    • Author(s)
      Yui N, Uchida S, Sasaki S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Low salt intake decreased transcription and protein level of KLHL3 in mouse kidney2013

    • Author(s)
      Susa K, Sohara E, Zeniya M, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in AQP11-Knockout Mice.2013

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Ser-261 phosphorylation is an endocytic signal of aquaporin-2 water channel.2013

    • Author(s)
      Yui N, Uchida S, Sasaki S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] WNK3 Regulates Blood Pressure Through the Regulation of Vascular OSR1/SPAK-NKCC1 Phosphorylation Cascade2013

    • Author(s)
      Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in AQP11-Knockout Mice.2013

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Clinical Significance of Urinary Thiazide-Sensitive Na-Cl Cotransporter (NCC) Measurement by Newly Development Enzyme-Linked Immunosorbent Assays.2013

    • Author(s)
      Isobe K, Mori T, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Chemical library screening for WNK signaling inhibitors by using fluorescent correlation spectroscopy2013

    • Author(s)
      Mori T, Eriko K, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Analyses of KLHL3 mutants that cause Pseudohypoaldosteronism type II2013

    • Author(s)
      Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] KLHL2 interacts with and ubiquitinates WNK kinases2013

    • Author(s)
      Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] WNK3 Regulates Blood Pressure Through the Regulation of Vascular OSR1/SPAK-NKCC1 Phosphorylation Cascade.2013

    • Author(s)
      Zeniya M, Sohara E, Kita S, Iwamoto T, Susa K, Mori T, Oi K, Chiga M, Takahashi D, Yang SS, Lin SH, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Aberrant Glycosylation and Localization of Polycystin-1 Cause Polycystic Kidney in AQP11-Knockout Mice2013

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Horie S, Su X, Zhou J, Sasaki S, Uchida S.
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-07
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] KLHL2 interacts with and ubiquitinates WNK kinases2013

    • Author(s)
      Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Chemical library screening for WNK signaling inhibitors by using fluorescent correlation spectroscopy.2013

    • Author(s)
      Mori T, Eriko K, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Clinical Significance of Urinary Thiazide-Sensitive Na-Cl Cotransporter (NCC) Measurement by Newly Development Enzyme-Linked Immunosorbent Assays.2013

    • Author(s)
      Isobe K, Mori T, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Analyses of KLHL3 mutants that cause Pseudohypoaldosteronism type II2013

    • Author(s)
      Mori Y, Wakabayashi M, Mori T, Araki Y, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Chemical library screening for WNK signaling inhibitors by using fluorescent correlation spectroscopy.2013

    • Author(s)
      Mori T, Eriko K, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Impaired KLHL3-mediated ubiquitination of WNK4 activates OSR1 and SPAK kinases-NaCl cotransporter (NCC) signaling and causes hypertension2013

    • Author(s)
      Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, Rai T, Sasaki S, Uchida S
    • Organizer
      The 46^<st> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Atlanta
    • Year and Date
      2013-11-09
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] KLHL2 interacts with and ubiquitinates WNK kinases.2013

    • Author(s)
      Takahashi D, Mori T, Wakabayashi M, Mori Y, Susa K, Zeniya M, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 46th Annual meeting of American Society of Nephrology
    • Place of Presentation
      アトランタ, アメリカ合衆国
    • Data Source
      KAKENHI-PROJECT-25221306
  • [Presentation] Chemical library screening for direct SPAK inhibitors by a newly developed ELISA system2012

    • Author(s)
      Kikuchi E, Mori T, Isobe K, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-01
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Hereditary nephrogenic diabetes insipidus (NDI) in Japanese patients : Analysis of 73 families2012

    • Author(s)
      Sasaki S, Chiga M, Kikuchi E, Uchida S.
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-02
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] WNK4-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone2012

    • Author(s)
      Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-02
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Hereditary nephrogenic diabetes insipidus (NDI) in Japanese patients : Analysis of 73 families2012

    • Author(s)
      Sasaki S, Chiga M, Kikuchi E, Uchida S
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-02
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Hereditary nephrogenic diabetes insipidus (NDI) in Japanese patients: Analysis of 73 families.2012

    • Author(s)
      Sasaki S
    • Organizer
      The 45th Annual meeting of American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Generation and analysis of WT-WNK4 transgenic mice revealed the physiological role of WNK42012

    • Author(s)
      Mori T, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-01
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Hereditary nephrogenic diabetes insipidus (NDI) in Japanese patients: Analysis of 73 families.2012

    • Author(s)
      Sasaki S
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego Convention Center
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Chemical library screening for direct SPAK inhibitors by a newly developed ELISA system2012

    • Author(s)
      Kikuchi E, Mori T, Isobe K, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-01
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Generation and analysis of WT-WNK4 transgenic mice revealed the physiological role of WNK42012

    • Author(s)
      Mori T, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-01
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] WNK4-OSR1/SPAK-NCC signal cascade has circadian rhythm dependent on aldosterone2012

    • Author(s)
      Susa K, Sohara E, Isobe K, Chiga M, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 45th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2012-11-02
    • Data Source
      KAKENHI-PROJECT-24659413
  • [Presentation] Chemical library screening for drugs to correct intracellular mislocalization of R8L mutant barttin2011

    • Author(s)
      Nomura N, Naito S, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 44th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Renal phenotype of WNK3 knockout mouse2011

    • Author(s)
      Oi K, Sohara E, Rai T, Chiga M, Alessi DR, Sasaki S, Uchida S
    • Organizer
      The 44th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Generation and analyses of AQP11 BAC transgenic mice2011

    • Author(s)
      Inoue Y, Sohara E, Kobayashi K, Rai T, Ishibashi K, Sasaki S, Uchida S
    • Organizer
      The 44th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] High throughput screening of drugs that inhibit WNK-OSR1/SPAK signaling cascade2011

    • Author(s)
      Mori T, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 44th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia (USA)
    • Year and Date
      2011-11-12
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Evidence based CKD guideline in Japan.2010

    • Author(s)
      Sasaki S
    • Organizer
      The 12^<th> Asian Pacific Congress of Nephrology
    • Place of Presentation
      COEX, Seoul, Korea
    • Year and Date
      2010-06-05
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] 腎性尿崩症2010

    • Author(s)
      佐々木成
    • Organizer
      第53回日本腎臓学会学術総会ワークショップ
    • Place of Presentation
      神戸国際会議場, 神戸
    • Year and Date
      2010-06-16
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Treatment of Bartter syndrome type IV caused by R8L barttin mutation2010

    • Author(s)
      Nomura N, Masato T, Ohta E, Ohta A, Sohara E, Rai T, Sasaki S, Uchida S
    • Organizer
      The 43nd Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Denver (USA)
    • Year and Date
      2010-11-10
    • Data Source
      KAKENHI-PROJECT-22249032
  • [Presentation] Targeted disruption of pancreatic-specific water-Channel, aquaporin-12, results in increased susceptibility to drug-induced acute pancreatitis2009

    • Author(s)
      Ohta E, Itoh T, Nemoto T, Kumagai J, Ko S, Ishibashi K, Kawashima M, Uchida K, Ohta A, Rai T, Uchida S, Sasaki S.
    • Organizer
      World Congress of Nephrology 2009
    • Place of Presentation
      Milan
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Molecular pathogenesis of Bartter syndrome caused by R8L barttin mutation.2009

    • Author(s)
      Uchida S, Nomura N, Sugawara N, Morimoto T, Kondo Y, Naito S, Yui N, Oi K, Talat G, KMZ Hossain, Wakabayashi M, Nishida H, Ohta E, Ohta A, Sohara E, Rai T, Sasaki S.
    • Organizer
      40th NIPS International Symposium & Physiology of anion transport and cell volume regulation (PAT-CVR 2009)
    • Place of Presentation
      Okazaki
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Presentation] シンポジウム発表.Aquaporins and kidney disease : Insight into molecular pathogenesis2009

    • Author(s)
      佐々木成
    • Organizer
      第36回国際生理学会世界大会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Reciprocal interaction with G-Actin and tropomyosin is critical for AQP2 translocation to the apical membrane2008

    • Author(s)
      Noda Y, Li Y, Eto K, Horikawa S, Sasaki S.
    • Organizer
      The 41st Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] 教育講演 遺伝子異常に伴う尿細管疾患2007

    • Author(s)
      佐々木成
    • Organizer
      第37回日本腎臟学会東部学術大会
    • Place of Presentation
      埼玉県大宮市
    • Year and Date
      2007-10-05
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] 溝演 上皮輸送の構成因子とその統合2007

    • Author(s)
      佐々木成
    • Organizer
      情報計算化学生物学会(CBI)学会2007年大会
    • Place of Presentation
      広島県東広島市
    • Year and Date
      2007-10-03
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Neonatal kidneys of AQP11-disrupted mice exhibit enhanced apotosis followed by a remarkable slowing of cyst-formation by rapamycin treatment2007

    • Author(s)
      Kobayashi K, Ishibashi K, Sasaki S.
    • Organizer
      The 5^<th> International Conference of Aquaporin
    • Place of Presentation
      Nara
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] 教育講演 水電解質疾患の展開2007

    • Author(s)
      佐々木成
    • Organizer
      第104回日本内科学会総会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2007-04-04
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] President Address: New aspects of aquaporin.2007

    • Author(s)
      Sasaki S
    • Organizer
      The 5th International Conference of Aquaporin
    • Place of Presentation
      Nara, Japan
    • Year and Date
      2007-07-13
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] 特別講演 尿細管疾患の生理学・分子生物学研究の流れと未来展望2007

    • Author(s)
      佐々木成
    • Organizer
      第50回日本腎臟学会学術総会
    • Place of Presentation
      静岡県浜松市
    • Year and Date
      2007-05-27
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] 慢性腎不全の病態と治療2007

    • Author(s)
      佐々木成
    • Organizer
      平成19年度日本内科学会生涯教育講演会
    • Place of Presentation
      大阪府大阪市,神奈川横浜市,広島県広島市.
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] New regulation mechanisms of renal aquaporin.2007

    • Author(s)
      Sasaki S.
    • Organizer
      The Annual Meeting of Taiwan Society of Nephrology
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2007-12-08
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Generation and analysis of Wnk4D561A/+ knock-in mice.2007

    • Author(s)
      Yang S, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin S, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, Uchida S.
    • Organizer
      ISN- Nature Genetics Forefronts Symposium on Nephrogenetics: from Development to Physiology
    • Place of Presentation
      Danvers, USA
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Presentation] 溝演 水・電解質代謝に関わるチャネル・トランスポーターと疾患2007

    • Author(s)
      佐々木成
    • Organizer
      第2回産業医科大学大学院シンポジウム
    • Place of Presentation
      福岡県北九州市
    • Year and Date
      2007-07-24
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] 溝演 体内の水分調節とアクアポリン2007

    • Author(s)
      佐々木成
    • Organizer
      第32回日本香粧品学会
    • Place of Presentation
      東京都港区
    • Year and Date
      2007-06-07
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Comparison between AQP2 and ENaC in intracellular trafficking2007

    • Author(s)
      Meng H, Noda Y, Yamashita M, Hirai K, Horikawa S, Sasaki S.
    • Organizer
      The 5^<th> International Conference of Aquaporin
    • Place of Presentation
      Nara
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Identification of protein complex isolated with a mutant AQP2 that causes autosominal dominant nephrogenic diabetes insipidus.2006

    • Author(s)
      Araki Y, Sohara E, Rai T, Sasaki S, Uchida S.
    • Organizer
      The 39th Annual Meeting of American Society of Nephrology
    • Place of Presentation
      San Diego
    • Data Source
      KAKENHI-PROJECT-17081009
  • [Presentation] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice2005

    • Author(s)
      Sohara E, Rai T, Verkman A. S., Sasaki S, Uchida S.
    • Organizer
      38^<th> Annual Meeting of American Society of Nephrology
    • Place of Presentation
      Philadelphia
    • Year and Date
      2005-11-11
    • Data Source
      KAKENHI-PROJECT-17GS0312
  • [Presentation] Defective water and glycerol transport in the proximal tubules of AQP7 knockout mice.2005

    • Author(s)
      Sohara E, Rai T, Verkman AS, Sasaki S, Uchida S.
    • Organizer
      4th International Conference on Aquaporins
    • Place of Presentation
      Brussels
    • Data Source
      KAKENHI-PROJECT-17081009
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