KAWANO Seiko 川野誠子

Researcher Number	00177718 … More / 00017718 Less
Affiliation (Current)	2020: 駒沢女子大学, 人間健康学部, 教授
Affiliation (based on the past Project Information) *help	2010: Tokyo Medical and Dental University, 人間健康学部, 教授 2009: Komazawa Women's University, 人間健康学部・健康栄養学科, 教授 2008: Tokyo Medical and Dental University, 難治疾患研究所, 准教授 2001 – 2005: 東京医科歯科大学, 難治疾患研究所, 助教授 2004: 国立大学法人東京医科歯科大学, 難治疾患研究所, 助教授 2003 – 2004: 東京医科歯科大学, 医学部, 助教授 1993 – 1998: 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field	Principal Investigator General physiology / General physiology / Thoracic surgery Except Principal Investigator Circulatory organs internal medicine / 医薬分子機能学
Keywords	Principal Investigator クロライドチャネル / 筋小胞体 / 心筋細胞 / カルシュウム / 幹細胞 / リアノジン受容体 / ES細胞 / イオンチャネル / CFTR / Caチャネル … More Except Principal Investigator Na / K ATPase / HERG / trafficking defect / tyrosine kinase / c-Src / glycosilation / maturation / cibenzoline / HCN4 / Ca^<2+>放出 / 筋小胞体 / リアノジン受容体チャネル / 人工脂質膜 / Cl-チャネル / リャノジン受容体チャネル / 小胞体 / 隣酸化 / Ryanodine receptor Ca^<2+> release channel / sarcoplasmic reticulum / artificial lipid bilayr / Cl-channel / 蛋白リン酸化 / ATP感受性Kチャネル / HERG Kチャネル / L型Caチャネル / Ca放出リヤノジン受容体 / Caチャネル / リン酸化部位 / α受容体 / cGMP / Ca活性化Clチャネル / protein phosphorylation / L-type Ca^<2+> channel / ATP-sensitive / K^+ channel / HERG K^+ channel / Ca^<2+> -activated Cl^- -channel / Ryanodine receptor channel / Ca拮抗薬 / 光アフィニティラベリング / 薬物結合部位 / 構造生物学 / 新規化合物 / ドラッグデザイン / 光アフィニティラベリング / 心筋Caチャンネル / 精密合成化学 / 抗ペプチド抗体 / 薬理活性 / Calcium antagonist / photoaffinity labeling / drug binding site / structural biology / new compounds / drug design / 幹細胞 / イオンチャネル / KATPase / Ca交換系 / 心筋細胞 / 胚性幹細胞 / カルシウム / IP_3レセプター / Ca電流 / stem cells / ion channels / Ca exchanger / cardiomyocvtes Less

Investigation of the physiological functions of anion channels during the differentiation in stem cells.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用
- Principal Investigator
  
  HIRANO Yuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
間葉系幹細胞から心筋細胞への分化過程に於けるイオンチャネルの機能発現機序の検討Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
Electrophysiological properties of cardiomyocytes differentiated from mouse embrionic stem cells
- Principal Investigator
  
  HIRAYAMA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nippon Medical School
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
The functional development of excitation-contraction coupling during cardiomyogenesis in mouse embryonic stem cellsPrincipal Investigator
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical & Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
心筋に於けるCa2+活性化クロライドチャネルの機能と細胞内調節機構の解明Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
Modulatory mechanisms of cardiac ion channels.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
Intracellular regulation of Ca^<2+> release from cardiac sarcoplasmic reticulum.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute.

All 2011 2010 2005 2004 2003 2002 Other

All Journal Article Presentation

[Journal Article] Synergic effects of β-estradiol and crythromycin on hERG currents2011
- Author(s)
  F.Ando, A.Kuruma, S.Kawano
- Journal Title
  
  Journal of Membrane Biology
  
  Volume: 241 Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590206
[Journal Article] Synergic effects of β-estradiol and erythromycin on hERG currents.2011
- Author(s)
  Fumiaki Ando, Akinori Kuruma Seiko Kawano
- Journal Title
  
  Journal of Membrane Biology May 241(1)
  
  Pages: 31-8
- Data Source
  KAKENHI-PROJECT-20590206
[Journal Article] Na^+/K^+ ATPase and its functional coupling with Na^+/Ca^<2+> exchanger in mouse embryonic stem cells during differentiation into cardiomyocytes2005
- Author(s)
  K.Otsu, A.Kuruma, E.Yanagida, S.Shoji, T.Inoue, Y.Hirayama, H.Uematsu, Y.Hara, S.Kawano.
- Journal Title
  
  Cell Calcium
  
  Pages: 137-151
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Na^+/K^+ ATPase and its Functional Coupling with Na^+/Ca^<2+> in Mouse Embryonic Stem Cells during Differentiation into Cardiomyocytes2005
- Author(s)
  K.Otsu, A.Kuruma, H.Uematsu, S.Kawano, et al.
- Journal Title
  
  Cell Calcium 37
  
  Pages: 137-151
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells.2004
- Author(s)
  E.Yanagida, S.Shoji, Y.Hirayama, F.Yoshikawa, K.Otsu, H.Uematsu, M.Hiraoka, T.Furuichi, S.Kawano
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004
- Author(s)
  T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, S.Kawano, M.Hiraoka et al.
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Block of HERG current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu L-M, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Functional expression of Ca signaling pathways in mouse embryonic stem cells2004
- Author(s)
  E.Yanagida, S.Shoji, M.Hiraoka, T.Furuichi, S.Kawano
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Ca2+ signaling pathways in mouse embryonic stem cells2004
- Author(s)
  Yanagida E, Otsu Y, Hirayama Y, Shoji H, Uematsu M, Hiraoka M, Kawano S.
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590775
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka et al.
- Journal Title
  
  FEBS letter 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M.
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Aizawa Y, Ueda K,.., Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M.
- Journal Title
  
  FEBS Lett. 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
- Journal Title
  
  J.Mol.Cell.Cardiol 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003
- Author(s)
  Kocic I, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  Basic Res Cardiol 98
  
  Pages: 367-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Moving dipole analysis of normal and abnormal ventricular activation by magnetocardiography.2002
- Author(s)
  Hiyoshi Y, Sakurada H, Izumida N, Kawano S, Sawanobori T, Hiraoka M.
- Journal Title
  
  J Electrocardiol 35
  
  Pages: 105-114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Presentation] BLOCKING KINETICS OF CFTR CHANNEL BY AROMATIC CARBOXYLATE POSITIONAL ISOMERS CHARACTERISED USING A NOVEL AMPLITUDE DISTRIBUTION ANALYSIS METHOD2010
- Author(s)
  Ying-Chun Yu, Yoshiro Sohma, Seiko Kawano, et al
- Organizer
  54^<th> Biophysical Society(USA)
- Place of Presentation
  アメリカ合衆国、サンスランシスコ、カリフォルニア
- Year and Date
  2010-02-22
- Data Source
  KAKENHI-PROJECT-20590206
[Presentation] Blocking kinetics of cftr channel by aromatic carboxylate positional isomers characterised using a novel amplitude distribution analysis method.
- Author(s)
  Ying-Chun Yu、Yoshiro Sohma, Seiko Kawano, et al
- Organizer
  in 54^<th> Biophysical Society (USA)
- Place of Presentation
  at San Francisco
- Data Source
  KAKENHI-PROJECT-20590206

1. HIRAOKA Masayasu (80014281)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. HIRANO Yuji (00181181)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ICHINOSE Shizuko (60014156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAWANO Seiko (00017718)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ISHIZUKA Tadao (60176203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YAMAGATA Kazuo (10299323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. HIRAYAMA Yoshiyuki (50322516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 吉川文生 (70342871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. CORONAD Roberts

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HARTZELL Criss

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. FOZZARD Harry A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NABATA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. CORONADO Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAWANO Seiko 川野 誠子

Research Projects

Research Products

Co-Researchers

Investigation of the physiological functions of anion channels during the differentiation in stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

間葉系幹細胞から心筋細胞への分化過程に於けるイオンチャネルの機能発現機序の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Electrophysiological properties of cardiomyocytes differentiated from mouse embrionic stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional development of excitation-contraction coupling during cardiomyogenesis in mouse embryonic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

心筋に於けるCa2+活性化クロライドチャネルの機能と細胞内調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulatory mechanisms of cardiac ion channels.

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Intracellular regulation of Ca^<2+> release from cardiac sarcoplasmic reticulum.Principal Investigator

Principal Investigator

Project Period (FY)

KAWANO Seiko 川野誠子