KAWANO Seiko 川野誠子

Researcher Number	00177718
Other IDs
Affiliation (based on the past Project Information) *help	2010: Tokyo Medical and Dental University, 人間健康学部, 教授 2009: Komazawa Women's University, 人間健康学部・健康栄養学科, 教授 2008: Tokyo Medical and Dental University, 難治疾患研究所, 准教授 2001 – 2005: 東京医科歯科大学, 難治疾患研究所, 助教授 2004: 国立大学法人東京医科歯科大学, 難治疾患研究所, 助教授 2003 – 2004: 東京医科歯科大学, 医学部, 助教授 1993 – 1998: 東京医科歯科大学, 難治疾患研究所, 助教授
Review Section/Research Field	Principal Investigator General physiology / General physiology / Thoracic surgery Except Principal Investigator Circulatory organs internal medicine / 医薬分子機能学
Keywords	Principal Investigator クロライドチャネル / 心筋細胞 / 筋小胞体 / イオンチャネル / ES細胞 / リアノジン受容体 / 幹細胞 / カルシュウム / Signal Transduction / Cardiac Myocyte … More / Ca^<2+> / Ryanodine Receptor / Sarcoplasmic Reticulum / 分化 / 分化誘導 / 胚性幹細胞 / Na-Ca交換機構 / Na-Kポンプ / Caチャネル / CFTR / Heart Failure / Remodeling / Lethal Arrhtymia / Cardiomyopathic hamster / K Channel / Ca Channel / HERG Channel / Arrhythmia / Ion Channel / 圧負荷 / ペースメーカーチャネル / 容積感受性クロールチャネル / 心不全 / 心肥大 / HERG電流密度減少 / チャネル蛋白発現 / 蛋白チロシン燐酸化 / L型Caチャネル / 一過性外向きKチャネル / チャネルリモデリング / チャネル輸送 / Long QT症候群 / KCNQ1 / HERG / 遺伝子異常 / リモデリング / 致死性不整脈 / 心筋症ハムスター / Kチャネル / HERGチャネル / 不整脈 / Na^+・K^+ pump / Na^+ Ca^<2+> exchanger / Ca^<2+> signaling pathway / Ryanodine receptor / IP3 receptor / excitation-contraction coupling / cardiomyocyte / ES cell / 心筋 / 容量性カルシュウム流入 / カルシュウムチャネル / Na-K pump / Na-Ca exchanger / plasma membrane Ca pump / Caシグナル伝達 / Caシグナル伝達経路 / IP3受容体 / 興奮-収縮連関 / Cl-channel / カルモジュリン / Mg^<2+> / 細胞内Ca^<2+> / C1-channel / ClC family / Ca / トランスポーター / クロライドチンネル / 間葉系幹細胞 / 脂肪細胞 / Calcium / T-type / L-type / 心筋分化 / アデニンヌクレオチド / 電気生理学 / 人工脂質膜 / ATP通過 / パッチクランプ / クロライド電流 / イオン透過性 … More Except Principal Investigator K ATPase / Na / cardiomyocvtes / Ca exchanger / ion channels / stem cells / Ca電流 / IP_3レセプター / カルシウム / 胚性幹細胞 / 心筋細胞 / Ca交換系 / KATPase / イオンチャネル / 幹細胞 / drug design / new compounds / structural biology / drug binding site / photoaffinity labeling / Calcium antagonist / 薬理活性 / 抗ペプチド抗体 / 精密合成化学 / 心筋Caチャンネル / 光アフィニティラベリング / ドラッグデザイン / 新規化合物 / 構造生物学 / 薬物結合部位 / 光アフィニティラベリング / Ca拮抗薬 / Ryanodine receptor channel / Ca^<2+> -activated Cl^- -channel / HERG K^+ channel / K^+ channel / ATP-sensitive / L-type Ca^<2+> channel / protein phosphorylation / Ca活性化Clチャネル / cGMP / α受容体 / リン酸化部位 / Caチャネル / Ca放出リヤノジン受容体 / L型Caチャネル / HERG Kチャネル / ATP感受性Kチャネル / 蛋白リン酸化 / Cl-channel / artificial lipid bilayr / sarcoplasmic reticulum / Ryanodine receptor Ca^<2+> release channel / 隣酸化 / 小胞体 / リャノジン受容体チャネル / Cl-チャネル / 人工脂質膜 / リアノジン受容体チャネル / 筋小胞体 / Ca^<2+>放出 / HCN4 / cibenzoline / maturation / glycosilation / c-Src / tyrosine kinase / trafficking defect / HERG Less

Investigation of the physiological functions of anion channels during the differentiation in stem cells.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用
- Principal Investigator
  
  HIRANO Yuji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
間葉系幹細胞から心筋細胞への分化過程に於けるイオンチャネルの機能発現機序の検討Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
Electrophysiological properties of cardiomyocytes differentiated from mouse embrionic stem cells
- Principal Investigator
  
  HIRAYAMA Yoshiyuki
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Nippon Medical School
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
The functional development of excitation-contraction coupling during cardiomyogenesis in mouse embryonic stem cellsPrincipal Investigator
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical & Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels
- Principal Investigator
  
  NAKAYAMA Hitoshi
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  医薬分子機能学
- Research Institution
  Kumamoto University
小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
心筋に於けるCa2+活性化クロライドチャネルの機能と細胞内調節機構の解明Principal Investigator
- Principal Investigator
  
  川野誠子
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University
Modulatory mechanisms of cardiac ion channels.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
Intracellular regulation of Ca^<2+> release from cardiac sarcoplasmic reticulum.Principal Investigator
- Principal Investigator
  
  KAWANO Seiko
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute.

All 2011 2010 2005 2004 2003 2002 Other

All Journal Article Presentation

[Journal Article] Synergic effects of β-estradiol and erythromycin on hERG currents.2011
- Author(s)
  Fumiaki Ando, Akinori Kuruma Seiko Kawano
- Journal Title
  
  Journal of Membrane Biology May 241(1)
  
  Pages: 31-8
- Data Source
  KAKENHI-PROJECT-20590206
[Journal Article] Synergic effects of β-estradiol and crythromycin on hERG currents2011
- Author(s)
  F.Ando, A.Kuruma, S.Kawano
- Journal Title
  
  Journal of Membrane Biology
  
  Volume: 241 Pages: 31-38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590206
[Journal Article] Na^+/K^+ ATPase and its functional coupling with Na^+/Ca^<2+> exchanger in mouse embryonic stem cells during differentiation into cardiomyocytes2005
- Author(s)
  K.Otsu, A.Kuruma, E.Yanagida, S.Shoji, T.Inoue, Y.Hirayama, H.Uematsu, Y.Hara, S.Kawano.
- Journal Title
  
  Cell Calcium
  
  Pages: 137-151
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Na^+/K^+ ATPase and its Functional Coupling with Na^+/Ca^<2+> in Mouse Embryonic Stem Cells during Differentiation into Cardiomyocytes2005
- Author(s)
  K.Otsu, A.Kuruma, H.Uematsu, S.Kawano, et al.
- Journal Title
  
  Cell Calcium 37
  
  Pages: 137-151
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Functional expression of Ca2+ signaling pathways in mouse embryonic stem cells.2004
- Author(s)
  E.Yanagida, S.Shoji, Y.Hirayama, F.Yoshikawa, K.Otsu, H.Uematsu, M.Hiraoka, T.Furuichi, S.Kawano
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004
- Author(s)
  T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
- Journal Title
  
  J.Mol.Cell.Cardiol 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, S.Kawano, M.Hiraoka et al.
- Journal Title
  
  Journal of Molecular and Cellular Cardiology 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M.
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Ca2+ signaling pathways in mouse embryonic stem cells2004
- Author(s)
  Yanagida E, Otsu Y, Hirayama Y, Shoji H, Uematsu M, Hiraoka M, Kawano S.
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590775
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Aizawa Y, Ueda K,.., Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M.
- Journal Title
  
  FEBS Lett. 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Block of HERG current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu L-M, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka et al.
- Journal Title
  
  FEBS letter 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Functional expression of Ca signaling pathways in mouse embryonic stem cells2004
- Author(s)
  E.Yanagida, S.Shoji, M.Hiraoka, T.Furuichi, S.Kawano
- Journal Title
  
  Cell Calcium 36
  
  Pages: 135-146
- Data Source
  KAKENHI-PROJECT-15659049
[Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003
- Author(s)
  Kocic I, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  Basic Res Cardiol 98
  
  Pages: 367-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Moving dipole analysis of normal and abnormal ventricular activation by magnetocardiography.2002
- Author(s)
  Hiyoshi Y, Sakurada H, Izumida N, Kawano S, Sawanobori T, Hiraoka M.
- Journal Title
  
  J Electrocardiol 35
  
  Pages: 105-114
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Presentation] BLOCKING KINETICS OF CFTR CHANNEL BY AROMATIC CARBOXYLATE POSITIONAL ISOMERS CHARACTERISED USING A NOVEL AMPLITUDE DISTRIBUTION ANALYSIS METHOD2010
- Author(s)
  Ying-Chun Yu, Yoshiro Sohma, Seiko Kawano, et al
- Organizer
  54^<th> Biophysical Society(USA)
- Place of Presentation
  アメリカ合衆国、サンスランシスコ、カリフォルニア
- Year and Date
  2010-02-22
- Data Source
  KAKENHI-PROJECT-20590206
[Presentation] Blocking kinetics of cftr channel by aromatic carboxylate positional isomers characterised using a novel amplitude distribution analysis method.
- Author(s)
  Ying-Chun Yu、Yoshiro Sohma, Seiko Kawano, et al
- Organizer
  in 54^<th> Biophysical Society (USA)
- Place of Presentation
  at San Francisco
- Data Source
  KAKENHI-PROJECT-20590206

1. HIRAOKA Masayasu (80014281)

# of Collaborated Projects: 7 results

# of Collaborated Products: 11 results
2. HIRANO Yuji (00181181)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. KUNIYASU Akihiko (90241348)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. NAKAYAMA Hitoshi (70088863)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. ICHINOSE Shizuko (60014156)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. ISHIZUKA Tadao (60176203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAGATA Kazuo (10299323)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HIRAYAMA Yoshiyuki (50322516)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 吉川文生 (70342871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. CORONAD Roberts

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HARTZELL Criss

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FOZZARD Harry A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. NABATA Hiroyuki

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. CORONADO Rob

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KAWANO Seiko 川野 誠子

Research Projects

Research Products

Co-Researchers

Investigation of the physiological functions of anion channels during the differentiation in stem cells.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

間葉系幹細胞から心筋細胞への分化過程に於けるイオンチャネルの機能発現機序の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Electrophysiological properties of cardiomyocytes differentiated from mouse embrionic stem cells

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The functional development of excitation-contraction coupling during cardiomyogenesis in mouse embryonic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Development of the 4th generation calcium antagonists based on molecular revealing the binding sites in calcium channels

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

小胞体膜由来クロライドチャネルの機能と構造に関する研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

心筋に於けるCa2+活性化クロライドチャネルの機能と細胞内調節機構の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Modulatory mechanisms of cardiac ion channels.

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Investigation of pathophysiological properties of ion channels on cardiac sarcoplasmic reticulum.

Principal Investigator

Project Period (FY)

Research Category

Research Institution

Intracellular regulation of Ca^<2+> release from cardiac sarcoplasmic reticulum.Principal Investigator

Principal Investigator

Project Period (FY)

KAWANO Seiko 川野誠子