HIRANO Yuhi 平野裕司

… Alternative Names

Researcher Number	00181181
Other IDs
Affiliation (based on the past Project Information) *help	2002 – 2005: 東京医科歯科大学, 難治疾患研究所, 助教授 2004: 国立大学法人東京医科歯科大学, 難治疾患研究所, 助教授 1997 – 2000: 東京医科歯科大学, 難治疾患研究所, 助教授 1989 – 1996: 東京医科歯科大学, 難治疾患研究所, 助手 1990: 東京医科歯科大学難治疾患研究所, 助手
Review Section/Research Field	Principal Investigator Circulatory organs internal medicine / Circulatory organs internal medicine Except Principal Investigator Circulatory organs internal medicine / Thoracic surgery
Keywords	Principal Investigator Caチャネル / BHK細胞 / single channel recording / カルシウムイオン / Fura 2 / クローン発現系 / c-Src / fura2 / trafficking defect / voltage-dependent block … More Except Principal Investigator 活動電位再分極相 / 致死性不整脈 / dominant negative suppression / Caチャネル / ATP感受性Kチャネル / HERG Kチャネル / ADP / パッチ・クランプ法 / L型Caチャネル / 不整脈 / 遅延整流K電流 / 一過性外向き電流 / 圧負荷 / アクチン細骨格 / HERG Channel / 不活性化状態親和性 / 膜電流 / 女性ホルモン / Patch-clamp technique / K^+ channel / I_K電流遮断薬 / Na^+チャネル抑制の動態 / Lethal Arrhtymia / Ca放出リヤノジン受容体 / Na活性型K電流 / 膜電位感受性色素 / 使用依存性ブロック / ロテイン・カイネース / 再活性化 / 抗不整脈薬 / リン酸化部位 / 荷電型と非荷電型薬物 / K Channel / 興奮旋回 / イオン化型と非イオン化型薬剤 / class I antiarrhythmic drugs / イオン化型と非イオン化型薬物 / Na^+ channel / intracellular ATP / 脱活性化の促進 / アシドージス / 光学的測定 / Ca Channel / 容積感受性クロールチャネル / I群抗不整脈薬 / K電流抑制 / ATPの加水分解 / 遺伝子異変 / ペースメーカーチャネル / optical recording / Co^<2+> / チャネルリモデリング / Whole-cell current recordings / State-dependent affinity / 心肥大 / 単一心筋細胞 / QT延長症候群 / Arrhythmia / アクチン細胞骨格 / チャネル輸送 / protein kinase C / Ion Channel / patch-clamp technique / Ca^<2+>放出 / 蛋白チロシン燐酸化 / Kチャネル / KCNQ1 / コンピュ-タ・シミュレ-ション / プロティン・カイネース / 心電活動 / 活性化過程 / repolarization / long QT syndrome / リモデリング / ATPk感受性Kチャネル / Ca^<2+>-influx / Ca^<2+> -activated Cl^- -channel / Ca^<2+>電流 / 撃発活動 / 遅延外向きK^+電流 / HERGチャネル / acceleration of inactivation / 変異チャネル / アコニチン細動 / α受容体 / 再分極 / 細胞内活性化因子 / Remodeling / Ca活性化Clチャネル / チャネル状態親和性 / 内向きhump電流 / Ryanodine receptor channel / circus movement / 細胞内増加Ca^<2+> / rundown of the channel activity / 単離心室筋細胞 / 早期後脱分極 / 活性化状態親和性 / 蛋白リン酸化 / チャネル活性の失活(rundown) / voltage-sensitive dye / 電位センサー / HERG / K current suppression / 遅延整流K^+電流 / Ca^<2+>流入 / 心室筋活動電位 / 一過性外向きKチャネル / Increased internal Ca^<2+> / protein phosphorylation / 不活性化の促進 / mutant channels / 逆頻度依存性 / HERG K channels / HERG電流密度減少 / adenosine / Na^+チャネル / actin cytoskeleton / heart / electrical activity / ブロック動態と様式 / 活動電位持続時間 / 不整脈のシミュレ-ション / 心筋症ハムスター / Single heart cells / 内向き整流 / 遅延整流外向き電流 / Heart Failure / チャネル蛋白発現 / イオンチャネル / ATP-sensitive / 遺伝子異常 / Long QT症候群 / cGMP / チャネル抑制の速度 / パッチ・クラプ法 / 細胞内ATP / arrhythmia / 心筋Na^+チャネル / ventricular myocytes / 全細胞電流記録 / Mg^<2+>イオン / Blocking kinetics and modes / チャネルのrundown / Delayed outward K^+ current / 不活性化過程 / アデノシン / 心不全 / ATP-sensitive K^+ channel / L-type Ca^<2+> channel / Transient outward current / アチドーシス / HERG K^+ channel / Cardiomyopathic hamster / activation process Less

HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用Principal Investigator
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.
- Principal Investigator
  
  KAWANO Seiko, 平岡昌和
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Thoracic surgery
- Research Institution
  Tokyo Medical and Dental University
Modulation of ionic selectivity of cardiac Na channels : single channel analysis of "slip mode conductance"Principal Investigator
- Principal Investigator
  
  HIRANO Yuji
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo medical and Dental University
Molecular Mechanism of QT Prolongation due to dysfunction of HERG K^+ Channels
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Meducal and Dental University
Optical study on the generation of experimental arrhythmias with re-entry of the excitatory waves
- Principal Investigator
  
  SAKAI Tetsuro
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
BHK細胞へ発現させたL型Caチャネルの機能調節(2):燐酸化反応とprotein targetingPrincipal Investigator
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
BHK細胞へ発現させた心筋L型Caチャネルの機能調節とサブユニット構造Principal Investigator
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Tokyo Medical and Dental University
クローン発現系を用いた心筋Caチャネルのα1受容体刺激による機能調節Principal Investigator
- Principal Investigator
  
  平野裕司
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Modulatory mechanisms of cardiac ion channels.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Tokyo Medical and Dental University
Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
異常状況下でのI_K電流ブロッカーの頻度依存性効果
- Principal Investigator
  
  沢登徹
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Mgイオンによる致死性不整脈防止機序に関する研究
- Principal Investigator
  
  沢登徹
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordings
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical & Dental University, Medical Research Institute
Dual modulation of Ca channels by intracellular Ca^<2+> concentrationPrincipal Investigator
- Principal Investigator
  
  HIRANO Yuji
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University, Medical Research Institute
心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tokyo Medical and Dental University
Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for Arrhythmogenesis
- Principal Investigator
  
  HIRAOKA Masayasu
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Medical Research Institution, Tokyo Medical and Dental University

All 2004 2003 2002

All Journal Article

[Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.2004
- Author(s)
  Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano, Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 27194-27198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Hiraoka M, et al.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004
- Author(s)
  T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
- Journal Title
  
  J.Mol.Cell.Cardiol 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004
- Author(s)
  Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M.
- Journal Title
  
  J.Mol.Cell.Cardiol. 37
  
  Pages: 1205-1211
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D533N, associated with cardiac arrhythmia2004
- Author(s)
  Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 27194-27198
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] The effects of K+ channels modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M
- Journal Title
  
  J.Pharmacol.Sci 95
  
  Pages: 27-32
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004
- Author(s)
  Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
- Journal Title
  
  FEBS Letters 574
  
  Pages: 145-150
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004
- Author(s)
  Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004
- Author(s)
  Aizawa Y, Ueda K,.., Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M.
- Journal Title
  
  FEBS Lett. 574
  
  Pages: 145-150
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Functional characterization of a trafficking-defective HCN4mutation, D533N, associated with cardiac arrhythmia2004
- Author(s)
  Ueda K, Nakamura K,...Hirano Y, Hiraoka M, Kimura A et al.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 27194-27198
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M
- Journal Title
  
  J.Pharmacol.Sci 95
  
  Pages: 189-195
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] The effects of K+ channel modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea-pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  J.Pharmacol.Sci. 95
  
  Pages: 189-195
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes.2004
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  J.Pharmacol.Sci. 95
  
  Pages: 185-195
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of HERG current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004
- Author(s)
  Hiramatsu M, Wu L-M, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
- Journal Title
  
  Heart Vessels 19
  
  Pages: 137-143
- Data Source
  KAKENHI-PROJECT-16659200
[Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003
- Author(s)
  Kocic I, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  Basic Res Cardiol 98
  
  Pages: 367-379
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003
- Author(s)
  Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
- Journal Title
  
  J Cardiovasc Pharmacol 42
  
  Pages: 410-418
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Block of recombinant KCNQ1/KCNE1 K channels (I_<KS>) by intracellular Na and its implications on action potential repolarization.2003
- Author(s)
  Orikabe M, Hirano Y, Isobe M, Hiraoka M.
- Journal Title
  
  Jpn.J.Physiol. 53
  
  Pages: 417-425
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404
[Journal Article] Rate-dependent changes in action potential durations and membrane currents in hamster ventricular myocytes.2002
- Author(s)
  Kocic I, Hirano Y, Hiraoka M.
- Journal Title
  
  Pflugers Arch 443
  
  Pages: 353-361
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370404

1. HIRAOKA Masayasu (80014281)

# of Collaborated Projects: 10 results

# of Collaborated Products: 17 results
2. SAWANOBORI Tohru (00014217)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. KAWANO Seiko (00177718)

# of Collaborated Projects: 4 results

# of Collaborated Products: 12 results
4. HORIKAWA Saburo (10127136)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. FURUKAWA Tetsushi (80251552)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SAKAI Tetsuro (40153845)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SATO Katsushige (80291342)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. MOMOSE Yoko (70251501)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KAMINO Kohtaro (40025630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. NAKAYAKA Hitoshi (70088863)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. KUNIYASU Akihikko (90241348)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. HARTZELL Criss

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FOZZARD Harry A

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

HIRANO Yuhi 平野 裕司

HIRANO Yuji 平野 裕司

平野 祐司 ヒラノ ユウジ

Research Projects

Research Products

Co-Researchers

HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Modulation of ionic selectivity of cardiac Na channels : single channel analysis of "slip mode conductance"Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

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Principal Investigator

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BHK細胞へ発現させたL型Caチャネルの機能調節(2):燐酸化反応とprotein targetingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

BHK細胞へ発現させた心筋L型Caチャネルの機能調節とサブユニット構造Principal Investigator

Principal Investigator

Project Period (FY)

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Research Institution

クローン発現系を用いた心筋Caチャネルのα1受容体刺激による機能調節Principal Investigator

Principal Investigator

Project Period (FY)

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Research Field

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Principal Investigator

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Research Institution

Principal Investigator

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Principal Investigator

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Principal Investigator

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Principal Investigator

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Dual modulation of Ca channels by intracellular Ca^<2+> concentrationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

HIRANO Yuhi 平野裕司

HIRANO Yuji 平野裕司

平野祐司ヒラノユウジ