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HIRANO Yuhi  平野 裕司

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… Alternative Names

HIRANO Yuji  平野 裕司

平野 祐司  ヒラノ ユウジ

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Researcher Number 00181181
Other IDs
Affiliation (based on the past Project Information) *help 2002 – 2005: 東京医科歯科大学, 難治疾患研究所, 助教授
2004: 国立大学法人東京医科歯科大学, 難治疾患研究所, 助教授
1997 – 2000: 東京医科歯科大学, 難治疾患研究所, 助教授
1989 – 1996: 東京医科歯科大学, 難治疾患研究所, 助手
1990: 東京医科歯科大学難治疾患研究所, 助手
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / Thoracic surgery
Keywords
Principal Investigator
Caチャネル / BHK細胞 / single channel recording / クローン発現系 / カルシウムイオン / Fura 2 / 交感神経の受容体 / 細胞内情報伝達 / パッチクランプ法 / HERG … More / trafficking defect / tyrosine kinase / c-Src / glycosilation / maturation / cibenzoline / HCN4 / Ca電流 / Fura2 / パッチクランプ / カルシウム電流 / 細胞内カルシウム濃度 / fura2 / 単離心筋細胞 / Ca channel / Intracellular Ca^<2+> / Patch clamp / イオン選択性 / Naチャネル / 電位依存性ブロック / 交感神経β受容体 / Na channel / ionic selectivity / Ca^<2+> ion / slip-mode conductance / voltage-dependent block / isoproterenol / veratridine … More
Except Principal Investigator
活動電位再分極相 / 致死性不整脈 / 遅延整流K電流 / パッチ・クランプ法 / ATP感受性Kチャネル / HERG Kチャネル / L型Caチャネル / Caチャネル / ADP / dominant negative suppression / 不整脈 / 心室筋活動電位 / コンピュ-タ・シミュレ-ション / 膜電流 / 不整脈のシミュレ-ション / 撃発活動 / 早期後脱分極 / アコニチン細動 / Mg^<2+>イオン / 内向きhump電流 / Na活性型K電流 / I_K電流遮断薬 / 逆頻度依存性 / 活動電位持続時間 / アチドーシス / 単一心筋細胞 / 全細胞電流記録 / 一過性外向き電流 / 遅延整流外向き電流 / Ca^<2+>流入 / 細胞内増加Ca^<2+> / Ca^<2+>放出 / 遅延外向きK^+電流 / Co^<2+> / Ca^<2+>電流 / 遅延整流K^+電流 / Single heart cells / Patch-clamp technique / Whole-cell current recordings / Transient outward current / Delayed outward K^+ current / Ca^<2+>-influx / Increased internal Ca^<2+> / I群抗不整脈薬 / Na^+チャネル / チャネル状態親和性 / ブロック動態と様式 / 単離心室筋細胞 / 使用依存性ブロック / イオン化型と非イオン化型薬物 / チャネル抑制の速度 / 荷電型と非荷電型薬物 / Na^+チャネル抑制の動態 / 心筋Na^+チャネル / 抗不整脈薬 / イオン化型と非イオン化型薬剤 / 活性化状態親和性 / 不活性化状態親和性 / パッチ・クラプ法 / class I antiarrhythmic drugs / Na^+ channel / State-dependent affinity / Blocking kinetics and modes / ventricular myocytes / patch-clamp technique / 蛋白リン酸化 / Ca放出リヤノジン受容体 / リン酸化部位 / α受容体 / cGMP / Ca活性化Clチャネル / protein phosphorylation / L-type Ca^<2+> channel / ATP-sensitive / K^+ channel / HERG K^+ channel / Ca^<2+> -activated Cl^- -channel / Ryanodine receptor channel / チャネルのrundown / 細胞内ATP / アクチン細骨格 / アデノシン / ロテイン・カイネース / プロティン・カイネース / ATPk感受性Kチャネル / 細胞内活性化因子 / チャネル活性の失活(rundown) / ATPの加水分解 / 再活性化 / アクチン細胞骨格 / ATP-sensitive K^+ channel / rundown of the channel activity / intracellular ATP / actin cytoskeleton / adenosine / protein kinase C / QT延長症候群 / 変異チャネル / 活性化過程 / 不活性化の促進 / K電流抑制 / 再分極 / 不活性化過程 / 電位センサー / 女性ホルモン / アシドージス / 内向き整流 / 脱活性化の促進 / 遺伝子異変 / long QT syndrome / HERG K channels / mutant channels / activation process / acceleration of inactivation / K current suppression / repolarization / 心電活動 / 興奮旋回 / 膜電位感受性色素 / 光学的測定 / electrical activity / circus movement / optical recording / voltage-sensitive dye / heart / arrhythmia / イオンチャネル / HERGチャネル / Kチャネル / 心筋症ハムスター / リモデリング / 遺伝子異常 / HERG / KCNQ1 / Long QT症候群 / チャネル輸送 / チャネルリモデリング / 一過性外向きKチャネル / 蛋白チロシン燐酸化 / チャネル蛋白発現 / HERG電流密度減少 / 心肥大 / 心不全 / 容積感受性クロールチャネル / ペースメーカーチャネル / 圧負荷 / Ion Channel / Arrhythmia / HERG Channel / Ca Channel / K Channel / Cardiomyopathic hamster / Lethal Arrhtymia / Remodeling / Heart Failure Less
  • Research Projects

    (16 results)
  • Research Products

    (22 results)
  • Co-Researchers

    (13 People)
  •  HERG Kチャネル蛋白の膜輸送欠陥の改善とその薬物開発への応用Principal Investigator

    • Principal Investigator
      平野 裕司
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  The molecular mechanisms of remodeling of ion channels leading to arrhtymias in hypertrophy and cardiomyopathy.

    • Principal Investigator
      KAWANO Seiko, 平岡 昌和
    • Project Period (FY)
      2002 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Thoracic surgery
    • Research Institution
      Tokyo Medical and Dental University
  •  Modulation of ionic selectivity of cardiac Na channels : single channel analysis of "slip mode conductance"Principal Investigator

    • Principal Investigator
      HIRANO Yuji
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo medical and Dental University
  •  Molecular Mechanism of QT Prolongation due to dysfunction of HERG K^+ Channels

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1998 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Meducal and Dental University
  •  Optical study on the generation of experimental arrhythmias with re-entry of the excitatory waves

    • Principal Investigator
      SAKAI Tetsuro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  BHK細胞へ発現させたL型Caチャネルの機能調節(2):燐酸化反応とprotein targetingPrincipal Investigator

    • Principal Investigator
      平野 裕司
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  BHK細胞へ発現させた心筋L型Caチャネルの機能調節とサブユニット構造Principal Investigator

    • Principal Investigator
      平野 裕司
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  クローン発現系を用いた心筋Caチャネルのα1受容体刺激による機能調節Principal Investigator

    • Principal Investigator
      平野 裕司
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Modulatory mechanisms of cardiac ion channels.

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
  •  Study of intracellular modulation mechanisms of cardiac ATP-sensitive K^+ channels and their pathophysiological implications.

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  異常状況下でのI_K電流ブロッカーの頻度依存性効果

    • Principal Investigator
      沢登 徹
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Mgイオンによる致死性不整脈防止機序に関する研究

    • Principal Investigator
      沢登 徹
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  A classification of antiarrhythmic drugs based on the Na^+ channel blocking properties directly assessed by the cardiac Na^+ current recordings

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical & Dental University, Medical Research Institute
  •  Dual modulation of Ca channels by intracellular Ca^<2+> concentrationPrincipal Investigator

    • Principal Investigator
      HIRANO Yuji
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University, Medical Research Institute
  •  心室筋活動電位のコンピュ-タ・シミュレ-ションとそのソフト開発

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Tokyo Medical and Dental University
  •  Physiological Modulations of Cardiac K^+ Currents by Ca^<2+> and their Roles for Arrhythmogenesis

    • Principal Investigator
      HIRAOKA Masayasu
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Medical Research Institution, Tokyo Medical and Dental University

All 2004 2003 2002

All Journal Article

  • [Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D553N, associated with cardiac arrhythmia.2004

    • Author(s)
      Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano, Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 27194-27198

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004

    • Author(s)
      Hiramatsu M, Wu LM, Hirano Y, Hiraoka M, et al.
    • Journal Title

      Heart Vessels 19

      Pages: 137-143

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation.2004

    • Author(s)
      T.Sasano, K.Ueda, M Orikabe, Y.Hirano, S.Kawano, M.Yasunami, M.Isobe, A.Kimura, M.Hiraoka
    • Journal Title

      J.Mol.Cell.Cardiol. 37

      Pages: 1205-1211

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      T.Sasano, Y.Hirano, S.Kawano, M.Hiraoka, et al.
    • Journal Title

      J.Mol.Cell.Cardiol 37

      Pages: 1205-1211

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Novel C-terminus frameshift mutation, 1122fs/147, of HERG in LQT2 : additional amino acids generated by frameshift cause accelerated inactivation2004

    • Author(s)
      Sasano T, Ueda K, Orikabe M, Hirano Y, Kawano S, Yasunami M, Isobe M, Kimura A, Hiraoka M.
    • Journal Title

      J.Mol.Cell.Cardiol. 37

      Pages: 1205-1211

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] Functional characterization of a trafficking-defective HCN4 mutation, D533N, associated with cardiac arrhythmia2004

    • Author(s)
      Ueda K, Nakamura K, Hayashi T, Inagaki N, Takahashi M, Arimura T, Morita H, Higashiuesato Y, Hirano Y, Yasunami M, Takishita S, Yamashina A, Ohe T, Sunamori M, Hiraoka M, Kimura A
    • Journal Title

      J.Biol.Chem. 279

      Pages: 27194-27198

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] The effects of K+ channels modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea pig ventricular myocytes.2004

    • Author(s)
      Kocic I, Hirano Y, Hiraoka M
    • Journal Title

      J.Pharmacol.Sci 95

      Pages: 27-32

    • NAID

      10013054366

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004

    • Author(s)
      Y.Aizawa, S.Kawano, Y.Hirano, M.Hiraoka, et al.
    • Journal Title

      FEBS Letters 574

      Pages: 145-150

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Truncated KCNQ1. mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004

    • Author(s)
      Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
    • Journal Title

      FEBS Letters 574

      Pages: 145-150

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect.2004

    • Author(s)
      Y.Aizawa, K.Ueda, L.Wua, N.Inagaki, T.Hayashi, M.Takahashi, M.Ohta, S.Kawano, Y.Hirano, M.Yasunamic, Y.Aizawa, A.Kimura, M.Hiraoka
    • Journal Title

      FEBS Letters 574

      Pages: 145-150

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Block of Herg current expressed in HEK293 cells by the Na-channel blocker cibenzoline.2004

    • Author(s)
      Hiramatsu M, Wu LM, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
    • Journal Title

      Heart Vessels 19

      Pages: 137-143

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Truncated KCNQ1 mutant, A178fs/105, forms hetero-multimer channel with wild-type causing a dominant-negative suppression due to trafficking defect2004

    • Author(s)
      Aizawa Y, Ueda K,.., Kawano S, Hirano Y, Yasunami M, Aizawa Y, Kimura A, Hiraoka M.
    • Journal Title

      FEBS Lett. 574

      Pages: 145-150

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] Functional characterization of a trafficking-defective HCN4mutation, D533N, associated with cardiac arrhythmia2004

    • Author(s)
      Ueda K, Nakamura K,...Hirano Y, Hiraoka M, Kimura A et al.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 27194-27198

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] The effects of K+ channel modulators terikalant and glibenclamide on membrane potential changes induced by hypotonic challenge of guinea-pig ventricular myocytes.2004

    • Author(s)
      Kocic I, Hirano Y, Hiraoka M.
    • Journal Title

      J.Pharmacol.Sci. 95

      Pages: 189-195

    • NAID

      10013054366

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes2004

    • Author(s)
      Kocic I, Hirano Y, Hiraoka M
    • Journal Title

      J.Pharmacol.Sci 95

      Pages: 189-195

    • NAID

      10013294757

    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Hypotonic stress increases efficacy of rilmakalim, but not pinacidil, to activate ATP-sensitive K+current in guinea-pig ventricular myocytes.2004

    • Author(s)
      Kocic I, Hirano Y, Hiraoka M.
    • Journal Title

      J.Pharmacol.Sci. 95

      Pages: 185-195

    • NAID

      10013294757

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Block of HERG current expressed in HEK293 cells by the Na-channel blocker cibenzoline2004

    • Author(s)
      Hiramatsu M, Wu L-M, Hirano Y, Kawano S, Furukawa T, Hiraoka M.
    • Journal Title

      Heart Vessels 19

      Pages: 137-143

    • Data Source
      KAKENHI-PROJECT-16659200
  • [Journal Article] Effects of Na+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003

    • Author(s)
      Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
    • Journal Title

      J Cardiovasc Pharmacol 42

      Pages: 410-418

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Regional and frequency-dependent changes in action potentials and transient outward K^+ currents in ventricular myocytes from J-2-K cardiomyopathic hamsters.2003

    • Author(s)
      Kocic I, Hirano Y, Kawano S, Hiraoka M.
    • Journal Title

      Basic Res Cardiol 98

      Pages: 367-379

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Effects of Na^+ channel blocker, pilsicainide, on HERG current expressed in HEK-293 cells.2003

    • Author(s)
      Wu L-M, Orikabe M, Hirano Y, Kawano S, Hiraoka M.
    • Journal Title

      J Cardiovasc Pharmacol 42

      Pages: 410-418

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Block of recombinant KCNQ1/KCNE1 K channels (I_<KS>) by intracellular Na and its implications on action potential repolarization.2003

    • Author(s)
      Orikabe M, Hirano Y, Isobe M, Hiraoka M.
    • Journal Title

      Jpn.J.Physiol. 53

      Pages: 417-425

    • NAID

      10012733004

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • [Journal Article] Rate-dependent changes in action potential durations and membrane currents in hamster ventricular myocytes.2002

    • Author(s)
      Kocic I, Hirano Y, Hiraoka M.
    • Journal Title

      Pflugers Arch 443

      Pages: 353-361

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14370404
  • 1.  HIRAOKA Masayasu (80014281)
    # of Collaborated Projects: 10 results
    # of Collaborated Products: 17 results
  • 2.  SAWANOBORI Tohru (00014217)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 3.  KAWANO Seiko (00177718)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 4.  HORIKAWA Saburo (10127136)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  FURUKAWA Tetsushi (80251552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  SAKAI Tetsuro (40153845)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  SATO Katsushige (80291342)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  SATO Yoko (70251501)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  KAMINO Kohtaro (40025630)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  NAKAYAKA Hitoshi (70088863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KUNIYASU Akihikko (90241348)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  HARTZELL Criss
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  FOZZARD Harry A
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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