SUZUKI Hiroshi 鈴木裕

… Alternative Names

鈴木裕

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Researcher Number	50183421
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2011 – 2018: 旭川医科大学, 医学部, 教授 1999 – 2008: 旭川医科大学, 医学部, 教授 1992 – 1998: 旭川医科大学, 医学部, 助教授 1988 – 1990: 旭川医科大学, 医学部, 講師 1986: 旭川医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Biophysics / Functional biochemistry / Functional biochemistry / General medical chemistry Except Principal Investigator Functional biochemistry / 代謝生物化学 / Biological Sciences
Keywords	Principal Investigator リン酸化中間体 / Ca^<2+>-ATPase / カルシウムポンプ / P-type ATPase / 小胞体 / 能動輸送 / 筋小胞体 / ダリエー病 / エネルギー共役 / Ca^<2+>ポンプ … More / Ca^<2+> / ゴルジ装置 / Ca-ATPase / Caポンプ / 部位特異的変異 / 構造機能連関 / Ca-pump / Active transport / Sarco(endo)plasmic reticulum / SERCA / Ca^<2+> pump / Ca<2+>ポンプ / Mn^<2+>ポンプ / ゴルジ体 / ヘイリー・ヘイリー病 / Ca2+ポンプ / 構造アナログ / ATP分解 / 機能ドメイン / 角化 / P型カチオン輸送ATPase / リン酸化反応中間体 / 反応中間体構造アナログ / 反応機構 / 構造変化 / Sarcoplasmic reticulum / Phosphorylation / Structural analog / Metal fluoride / Reaction intermediate / Phosphorylated intermediate / ATP結合部位 / フルオレセイン5-イソチオシアネート / Sarcoplasmic Reticulum / Calcium Pump / ATP-Binding Sites / Fluorescein 5-Isothiocyanate / 品質管理 / Ca^<2+>ATPase / カルシウムATPアーゼ / Ca^<2+>-pump / sarcoplasmic reticulum / phosphorylated intermediate / quality control / site-directed mutagenesis / Ca ^<2+>ポンプ / Ca ^<2+>-ATPase / ドメイン構造 / ドメイン相互作用 / 遺伝病 / Ca ^<2+>動態 / Endplasmic reticulum / Darier's disease / Phosphorylate intermediate / ヘーリーヘーリー病 / Ca^<2+>Mn^<2+>ポンプ / Ca^<2+>Mn^<2+>-ATPase / SEARCA / Ca^<2+>輸送 / 疎水性相互作用 / Caホメオスタシス / Darier disease / Hailey-Hailey disease / Golgi apparatus / Mn^<2+> pump / Mn^<2+>-ATPase / active transport / flippase / energy coupling / ENU-mutagenesis / 生物物理 / 酵素 / 生体分子 / 蛋白質 / 癌 / Ca輸送 / 蛋白構造変化 / 発癌 / mutations / kinetics / Structure and Function / tumor … More Except Principal Investigator 筋小胞体 / カルシウムポンプ / カルシウムATPアーゼ / 分子機構 / 触媒部位 / 構造解析 / Ca^<2+>-ATPase / 機能解析 / 化学修飾 / 部位特異的変異 / ATPase / A23187 / ナトリウムポンプ / 蛍光プローブ / I-EDANS / 反応機構 / 構造・機能解析 / アミノ酸残基 / 生物物理 / 能動輸送 / 膜蛋白質 / イオンポンプ / X線結晶 / X線結晶解析 / Ca-ATPase / カルシウムイオノフォア / Na,K-ATPase / 蛍光異方性 / コンホメーション変化 / Na^+,K^+-ATPase / 作動機構 / メカニズム / カルシウム / ATPア-ゼ / 低親和性ATP結合部位 / 蛍光プロ-ブ / FSBεA / コンホメ-ション変化 / Sarcoplasmic Reticulum / Calcium Pump / Catalytic Site / Structure Analysis / Transport Mechamism / Calcium / Ca^<2+>-ATPアーゼ / アルギニン残基 / リン酸化酵素 / 構造 / 機能 / Site-directed mutagenesis / Arginine residue / Phosphoenzyme hydrolysis / Sarcoplasmic reticulum / 1分子観察 / プロトンポンプ / Sodium Pump / Fluorescent Probe / Single-molecule observation / Proton Pump Less

P-type pump ; Molecular basis of energy coupling and carcinogenesis caused by defectsPrincipal Investigator
- Principal Investigator
  
  Suzuki Hiroshi
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
Molecular basis of P-type ion pumps and diseases caused by pump defects.Principal Investigator
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
Molecular Mechanism of Endoplasmic and Golgi Cation Pumps and Diseases Caused by Their DefectsPrincipal Investigator
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Asahikawa Medical College
Mechanism in Energy Transduction of Ca^<2+> Pump and Molecular Basis of Related Genetic DiseasesPrincipal Investigator
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biophysics
- Research Institution
  Asahikawa Medical College
P型イオンポンプによる能動輪送機構の構造的解明
- Principal Investigator
  
  豊島近
- Project Period (FY)
  2002 – 2006
- Research Category
  
  Grant-in-Aid for Creative Scientific Research
- Research Institution
  The University of Tokyo
Structure and Function of Sarco(endo)plasmic Reticulum Ca^<2+>-ATPase and Mechanism of Darier's Diseases Caused by its AbnormalityPrincipal Investigator
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
Investigation of reaction mechanism and higher oligomeric structure of Na-pump based on single-molecule observation technique.
- Principal Investigator
  
  KAYA Shunji
- Project Period (FY)
  2001 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  HOKKAIDO UNIVERSITY
Research on molecular mechanism of sarcoplasmic reticulum Ca^<2+>-ATPase with site-directed mutagenesisPrincipal Investigator
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
Structure and function of the catalytic site of sarcoplasmic reticulum Ca^<2+>-ATPase.
- Principal Investigator
  
  KANAZAWA Tohru
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
筋小胞体Ca^<2+>-ATPaseの構造と機能-化学修飾と部位特異的変異による研究
- Principal Investigator
  
  金沢徹
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
筋小胞体カルシウムポンプの触媒部位を構成するアミノ酸残基の同定と機能解析
- Principal Investigator
  
  金沢徹
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
筋小胞体カルシウムポンプの触媒部位の構造と機能
- Principal Investigator
  
  KANAZAWA Tohru
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Functional biochemistry
- Research Institution
  Asahikawa Medical College
Studies on Structure and Function of the ATP-Binding sites of the Sarcoplasmic Reticulum Calcium Pump.Principal Investigator
- Principal Investigator
  
  SUZUKI Hiroshi
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Asahikawa Medical College
Study on the Structure of the Catalytic Site and the Transport Mechanism of the Sarcoplasmic Reticulum Calcium Pump
- Principal Investigator
  
  KANAZAWA Tohru
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Asahikawa Medical college
蛍光プローブによる筋小胞体カルシウムポンプの分子内作動機構に関する研究
- Principal Investigator
  
  金沢徹
- Project Period (FY)
  1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  代謝生物化学
- Research Institution
  Asahikawa Medical College
カルシウムポンプからカルシウムが遊離する機構
- Principal Investigator
  
  金沢徹
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Asahikawa Medical College

[Book] P-Type ATPases2015
- Author(s)
  Stefania J. Danko and Hiroshi Suzuki
- Total Pages
  544
- Publisher
  Humana Press, Springer
- Data Source
  KAKENHI-PROJECT-15H04346
[Book] P-Type ATPases2015
- Author(s)
  Hiroshi Suzuki
- Total Pages
  544
- Publisher
  Humana Press, Springer
- Data Source
  KAKENHI-PROJECT-15H04346
[Journal Article] Membrane Perturbation of ADP-insensitive Phosphoenzyme of Ca2+-ATPase Modifies Gathering of Transmembrane Helix M2 with Cytoplasmic Domains and Luminal Gating2017
- Author(s)
  Stefania Danko, Kazuo Yamasaki1, Takashi Daiho1, and Hiroshi Suzuki
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Pages: 1-12
- DOI
  10.1038/srep41172
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04346, KAKENHI-PROJECT-26440017, KAKENHI-PROJECT-15K06988
[Journal Article] Nanodisc-based kinetic assays reveal distinct effects of phospholipid head groups on the phosphoenzyme transition of sarcoplasmic reticulum Ca2+-ATPase2017
- Author(s)
  Yamasaki K, Daiho T, Danko S, Yasuda S, Suzuki H.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 292 Pages: 20218-20227
- DOI
  10.1074/jbc.m117.816702
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07297, KAKENHI-PROJECT-15H04346, KAKENHI-PROJECT-15K06988
[Journal Article] Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors2016
- Author(s)
  Toki H,Minowa O, Inoue M, Motegi H, Karashima Y, Ikeda A, Kaneda H, Sakuraba Y, Saiki Y, Wakana S, Suzuki H, Gondo Y, Shiroishi T, Noda T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 476 Pages: 175-182
- DOI
  10.1016/j.bbrc.2016.04.136
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25241016, KAKENHI-PROJECT-15H04346
[Journal Article] Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase2016
- Author(s)
  Takashi Daiho1, Kazuo Yamasaki, Stefania Danko, and Hiroshi Suzuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 291 Pages: 24688-24701
- DOI
  10.1074/jbc.m116.759704
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H04346, KAKENHI-PROJECT-26440017, KAKENHI-PROJECT-15K06988
[Journal Article] Assembly of a Tyr122-hydrophobic Cluster in Sarcoplasmic Reticulum Ca2+-ATPase Synchronizes Ca2+ Affinity-reduction and Release with Phosphoenzyme Isomerization2015
- Author(s)
  Yamasaki K., Daiho T., Danko S., and Suzuki H.
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 290 Pages: 27868-27879
- DOI
  10.1074/jbc.m115.693770
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K06988, KAKENHI-PROJECT-26440017, KAKENHI-PROJECT-15H04346
[Journal Article] Second transmembrane helix (M2) and long range coupling in Ca2+-ATPase.2014
- Author(s)
  Takashi Daiho, Kazuo Yamasaki, Stefania Danko, Hiroshi Suzuki
- Journal Title
  
  Journal od Biological Chemistry
  
  Volume: 289 Pages: 31241-31252
- DOI
  10.1074/jbc.m114.584086
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23370058, KAKENHI-PROJECT-24570147, KAKENHI-PROJECT-26440017
[Journal Article] Roles of long-range electrostatic domain interactions and K+ in phosphoenzyme transition of Ca2+-ATPase2013
- Author(s)
  Kazuo Yamasaki, Takashi Daiho, Stefania Danko, and Hiroshi Suzuki
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 288 Pages: 20646-20657
- DOI
  10.1074/jbc.m113.482711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23370058, KAKENHI-PROJECT-23570130, KAKENHI-PROJECT-24570147
[Journal Article] Roles of Tyr^<122>-hydrophobic Cluster and K^+ Binding in Ca^<2+>-releasing Process of ADP-insensitive Phosphoenzyme of Sarcoplasmic Reticulum Ca^<2+>-ATPase2008
- Author(s)
  Kazuo Yamasaki, Guoli Wang, Takashi Daiho, Stefania Danko, and Hiroshi Suzuki
- Journal Title
  
  The Journal of Biological Chemistry 283(43)
  
  Pages: 29144-29155
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370058
[Journal Article] Critical Role of Glu^<40>-Ser^<48> Loop Linking Actuator Domain and First Transmembrane Helix of Ca^<2+>-ATPase in Ca^<2+> Deocclusion and Release from ADP-insensitive Phosphoenzyme2007
- Author(s)
  Takashi Daiho, Kazuo Yamasaki, Stefania Danko, and Hiroshi Suzuki
- Journal Title
  
  The Journal of Biological Chemistry 282(47)
  
  Pages: 34429-34447
- NAID
  120003182903
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370058
[Journal Article] Molecular Mechanism of Ca-ATPase and Diseases Caused by Its120-126 Defects2006
- Author(s)
  Hiroshi Suzuki
- Journal Title
  
  (膜)Membrane 31(3)
  
  Pages: 120-126
- Data Source
  KAKENHI-PROJECT-18370058
[Journal Article] Comprehensive Analysis of Expression and Function of 51 Sarco(endo)plasmic Reticulum Ca^<2+>-ATPase Mutants Associated with Darier Disease2006
- Author(s)
  Yuki Miyauchi, Takashi Daiho, Kazuo Yamasaki, Hidetoshi Takahashi, Akemi Ishida-Yamamoto, Stefania Danko, Hiroshi Suzuki, and Hajime Iizuka
- Journal Title
  
  The Journal of Biological Chemistry 281(32)
  
  Pages: 22882-22895
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370058
[Journal Article] ATP2C1 is specifically localized in the basal layer of normal epidermis and its depletion triggers keratinocyte differentiation2006
- Author(s)
  Masaki Yoshida, Kazuo Yamasaki, Takashi Daiho, Hajime Iizuka, and Hiroshi Suzuki
- Journal Title
  
  Journal of Dermatological Science 43(1)
  
  Pages: 21-33
- NAID
  10020549262
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18370058
[Journal Article] Molecular Mechanism of Ca-ATPase and Diseases Caused by Its Defects2006
- Author(s)
  Hiroshi Suzuki
- Journal Title
  
  (膜)Membrane 31・3
  
  Pages: 120-126
- NAID
  10017581392
- Data Source
  KAKENHI-PROJECT-18370058
[Journal Article] カルシウムポンプのドメイン間相互作用変化とエネルギー変換2005
- Author(s)
  鈴木裕
- Journal Title
  
  生物物理 45・1
  
  Pages: 16-21
- NAID
  10015441996
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Changes in Cytoplasmic Domain Organization and Energy Transduction in Calcium Pump2005
- Author(s)
  Hiroshi Suzuki
- Journal Title
  
  生物物理 45・1
  
  Pages: 16-21
- NAID
  10015441996
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Changes in Cytoplasmic Domain Organization and Energy Transduction in Calcium Pump2005
- Author(s)
  Suzuki, H. et al.
- Journal Title
  
  SEIBUTSUBUTSURI 45(1)
  
  Pages: 16-21
- NAID
  10015441996
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Distinct Natures of Be/F-bound, Al/F-bound, and Mg/F-bound Stable Analogues of ADP-insensitive Phosphoenzyme Intermediate of Sarcoplasmic Reticulum Ca^<2+>-ATPase2004
- Author(s)
  Hiroshi Suzuki
- Journal Title
  
  生化学 76・8
  
  Pages: 782-782
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Structure and function of Ca pump and the molecular basis of genetic diseases caused by its mutations2004
- Author(s)
  Hiroshi Suzuki
- Journal Title
  
  生物物理 44・1
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Distinct natures of Be/F-bound, Al/F-bound, and Mg/F-bound stable analogues of an ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca^<2+>-ATPase2004
- Author(s)
  Suzuki, H. et al.
- Journal Title
  
  SEIKAGAKU 76(8)
  
  Pages: 782-782
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Distinct natures of Be/F-bound, Al/F-bound, and Mg/F-bound stable analogues of an ADP-insensitive phosphoenzyme intermediate of sarcoplasmic reticulum Ca^<2+>-ATPase2004
- Author(s)
  Hiroshi Suzuki
- Journal Title
  
  生化学 76・8
  
  Pages: 782-782
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Structure and function of Ca pump and the molecular basis of genetic diseases caused by its mutations2004
- Author(s)
  Suzuki, H. et al.
- Journal Title
  
  SEIBUTSUBUTSURI 44(1)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16370066
[Journal Article] Caポンプの構造機能連関とその異常による病態2004
- Author(s)
  鈴木裕
- Journal Title
  
  生物物理 44・S1
- Data Source
  KAKENHI-PROJECT-16370066
[Presentation] 筋小胞体Ca2+-ATPaseの脱共役モードについて2018
- Author(s)
  山崎和生、大保貴嗣、Danko Stefania、安田哲、鈴木裕
- Organizer
  日本生化学会　第91回大会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体カルシウムポンプのCa2+結合に及ぼす界面活性剤の効果2018
- Author(s)
  大保貴嗣、山崎和生、Danko Stefania、安田哲、鈴木裕
- Organizer
  日本生化学会　第91回大会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体Ca2+-ATPaseの脱共役モードについて2018
- Author(s)
  山崎和生、大保貴嗣、Danko Stefania、安田哲、鈴木裕
- Organizer
  日本生体エネルギー研究会　第44回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] デフォーカスイメージング法の確度評価とSERCA1a の構造変化検出に向けた試み2018
- Author(s)
  加藤孝信、藤村章子、山崎和生、大保貴嗣、Danko Stefania、鈴木裕、西坂崇之
- Organizer
  日本生体エネルギー研究会　第44回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] ナノディスク中の筋小胞体Ca2+-ATPaseに標識された単一蛍光分子の角度と明滅による中間体構造の評価2018
- Author(s)
  竹村勁哉、山崎和生、大保貴嗣、Danko Stefania、小島知樹、鈴木裕、政池知子
- Organizer
  日本生体エネルギー研究会　第44回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体カルシウムポンプのCa2+結合に及ぼす界面活性剤の効果2018
- Author(s)
  大保貴嗣、山崎和生、Danko Stefania、安田哲、鈴木裕
- Organizer
  日本生体エネルギー研究会　第44回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] フリッパーゼATP8A1の反応と安定性に対する界面活性剤および脂質の影響2018
- Author(s)
  安田哲、山崎和生、大保貴嗣、高津宏之、申惠媛、Danko Stefania、鈴木裕
- Organizer
  日本生化学会　第91回大会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] ヒトフリッパーゼATP8A1の反応機構解析2018
- Author(s)
  安田哲、山崎和生、大保貴嗣、高津宏之、申惠媛、Danko Stefania、鈴木裕
- Organizer
  日本生体エネルギー研究会　第44回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Effects of phospholipid’s head groups on the properties of sarcoplasmic reticulum Ca2+-ATPase embedded in nanodisc2017
- Author(s)
  Kazuo Yamasaki, Takashi Daiho, Stefania Danko, Satoshi Yasuda, Hiroshi Suzuki
- Organizer
  The 15th International ATPase Conference on “Na,K-ATPase and Related Transport ATPases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体カルシウムポンプの反応に及ぼす界面活性剤の効果2017
- Author(s)
  大保貴嗣、山崎和生、Stefania Danko、安田哲、鈴木裕
- Organizer
  日本生体エネルギー研究会　第43回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] フリッパーゼの生化学的反応機構の解析2017
- Author(s)
  安田哲、山崎　和生、大保　貴嗣、高津宏之、申　惠媛、Stefania Danko、鈴木　裕
- Organizer
  生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体カルシウムポンプ活性に対する脂質ヘッドグループ及び膜表面電荷の影響の解析2017
- Author(s)
  山崎　和生、大保　貴嗣、Stefania Danko、安田哲、鈴木　裕
- Organizer
  日本生体エネルギー研究会　第43回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] ナノディスクに組み込んだ筋小胞体Ca2+-ATPaseの活性に対する膜表面電荷の影響2017
- Author(s)
  山崎　和生、大保　貴嗣、Stefania Danko、安田哲、鈴木　裕
- Organizer
  生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] フリッパーゼの反応機構解析2017
- Author(s)
  安田哲、山崎　和生、大保　貴嗣、高津宏之、申　惠媛、Stefania Danko、鈴木　裕
- Organizer
  日本生体エネルギー研究会　第43回討論会
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Membrane Perturbation of ADP-insensitive Phosphoenzyme of Ca2+-ATPase Modifies Gathering of Transmembrane Helix M2 with Cytoplasmic Domains and Luminal Gating2017
- Author(s)
  Stefania Danko, Kazuo Yamasaki, Takashi Daiho, and Hiroshi Suzuki
- Organizer
  The 15th International ATPase Conference on “Na,K-ATPase and Related Transport ATPases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Glycine 105 as Pivot for a Critical Knee-like Joint between Cytoplasmic and Transmembrane Segments of the Second Transmembrane Helix in Ca2+-ATPase2017
- Author(s)
  Takashi Daiho, Kazuo Yamasaki, Stefania Danko, Hiroshi Suzuki
- Organizer
  The 15th International ATPase Conference on “Na,K-ATPase and Related Transport ATPases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Novel allelic mutations in murine Serca2 induce differential development of squamous cell tumors2017
- Author(s)
  Hideaki Toki, Osamu Minowa, Maki Inoue, Hiromi Motegi, Yuko Karashima, Ami Ikeda, Hideki Kaneda, Yoshiyuki Sakuraba, Yuriko Saiki, Shigeharu Wakana, Hiroshi Suzuki, Yoichi Gondo, Toshihiko Shiroishi, Tetsuo Noda
- Organizer
  The 15th International ATPase Conference on “Na,K-ATPase and Related Transport ATPases”
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体カルシウムポンプの活性に対する界面活性剤の影響2017
- Author(s)
  大保貴嗣、山崎和生、Stefania Danko、安田哲、鈴木裕
- Organizer
  生命科学系学会合同年次大会（第90回日本生化学会大会）
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Structure/function of Ca-ATPase revealed by mutations, kinetics, and structural analyses of reaction intermediates2017
- Author(s)
  Hiroshi Suzuki, Takashi Daiho, Kazuo Yamasaki, Satoshi Yasuda, Stefania Danko
- Organizer
  The 15th International ATPase Conference on “Na,K-ATPase and Related Transport ATPases”
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Caポンプのエネルギー共役；M2-helix膜貫通部分(M2m)と細胞質部分(M2c)をつなぐGly105の柔軟性の機能2016
- Author(s)
  大保貴嗣、山崎和生、Stefania Danko、鈴木裕
- Organizer
  日本生体エネルギー研究会　第42回討論会
- Place of Presentation
  名古屋
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Caポンプの素過程構造-機能連関：部位特異的変異、速度論、および中間体・遷移状態捕捉による解析2016
- Author(s)
  鈴木裕、大保貴嗣、山崎和生、Stefania Danko
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Invited
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 脂質ヘッドグループが筋小胞体カルシウムポンプ活性に及ぼす影響―ナノディスク組み込み標品を用いて―2016
- Author(s)
  山崎和生、大保貴嗣、Stefania Danko、鈴木裕
- Organizer
  日本生体エネルギー研究会　第42回討論会
- Place of Presentation
  名古屋
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] ナノディスクに組み込んだ標品を用いた筋小胞体Ca2+-ATPaseのEP転換ステップに及ぼす脂質組成及びA23187の影響の解析2016
- Author(s)
  山崎和生、大保貴嗣、Stefania Danko、鈴木裕
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Membrane Perturbation of ADP-insensitive Phosphoenzyme of Ca2+-ATPase Modifies Gathering of Transmembrane Helix M2 with Cytoplasmic Domains and Luminal Gating2016
- Author(s)
  Stefania Danko、山崎和生、大保貴嗣、鈴木裕
- Organizer
  日本生体エネルギー研究会　第42回討論会
- Place of Presentation
  名古屋
- Year and Date
  2016-12-19
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体Ca2+ポンプM2ヘリックスの膜貫通部分と細胞質部分の連結領域：エネルギー共役における役割2016
- Author(s)
  大保貴嗣、山崎和生、Stefania Danko、鈴木裕
- Organizer
  第89回日本生化学会大会
- Place of Presentation
  仙台
- Year and Date
  2016-09-25
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] ナノディスクへ組み込んだ筋小胞体カルシウムポンプを用いたタンパク質―脂質相互作用の解析2015
- Author(s)
  山崎和生、大保貴嗣、Danko Stefania 、鈴木裕
- Organizer
  日本生体エネルギー研究会第41回討論会
- Place of Presentation
  東京
- Year and Date
  2015-12-21
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体Ca2+ポンプのエネルギー共役におけるM2ヘリックス膜貫通部分（M2m）と細胞質部分（M2cyt）の連結領域の役割2015
- Author(s)
  大保貴嗣、山崎和生、Danko Stefania 、鈴木裕
- Organizer
  日本生体エネルギー研究会第41回討論会
- Place of Presentation
  東京
- Year and Date
  2015-12-21
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] Long-range Coupling between Catalytic and Transport Sites via Second Transmembrane Helix (M2) in Ca2+-ATPase2015
- Author(s)
  大保貴嗣、山崎和生、Danko Stefania 、鈴木裕
- Organizer
  日本生物物理学会第53回年会
- Place of Presentation
  金沢
- Year and Date
  2015-09-13
- Invited
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体Ca2+ポンプのエネルギー共役におけるM2ヘリックス膜貫通部分（M2m）と細胞質部分（M2cyt）の連結領域の役割2015
- Author(s)
  大保貴嗣、山崎和生、Danko Stefania 、鈴木裕
- Organizer
  日本生化学会第88回大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体Ca2+-ATPaseのEP転換ステップにおけるTyr122-Hydorophobic clusterの集合過程とエネルギー共役2015
- Author(s)
  山崎和生、大保貴嗣、Danko Stefania 、鈴木裕
- Organizer
  日本生化学会第88回大会
- Place of Presentation
  神戸
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15H04346
[Presentation] 筋小胞体Ca2+ポンプのヘリックスM2膜貫通部分と細胞質部分、およびその連結領域の役割2013
- Author(s)
  大保　貴嗣、山崎　和生、Danko Stefania、鈴木　裕
- Organizer
  日本生体エネルギー研究会　第39回討論会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体カルシウムポンプのナノディスクへの組み込みとその性質2013
- Author(s)
  山崎　和生、Danko Stefania、大保　貴嗣、鈴木　裕
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体Ca2+ポンプのヘリックスM2膜貫通部分（M2m）およびその連結領域の役割2013
- Author(s)
  大保　貴嗣、山崎　和生、Danko Stefania、鈴木　裕
- Organizer
  第86回日本生化学会大会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体カルシウムポンプのナノディスクへの組み込みとその性質2013
- Author(s)
  山崎　和生、Danko Stefania、大保　貴嗣、鈴木　裕
- Organizer
  日本生体エネルギー研究会　第39回討論会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] MECHANISM OF Ca2+-ATPase REVEALED BY MUTATIONS, KINETICS, AND DEVELOPMENT OF STABLE ANALOGS OF PHOSPHORYLATED INTERMEDIATES2012
- Author(s)
  鈴木　裕　（Hiroshi Suzuki）
- Organizer
  3rd International Workshop on Expression, Structure and Function of Membrane Proteins
- Place of Presentation
  Florence, Italy
- Invited
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体Ca^<2+>-ATPaseリン酸化中間体転換ステップにおける静電相互作用の効果とその定量化の試み2011
- Author(s)
  山崎和生、大保貴嗣、Danko Stefania、鈴木裕
- Organizer
  日本生体エネルギー研究会
- Place of Presentation
  京都
- Year and Date
  2011-12-20
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Roles of electrostatic interactions between cytoplasmic domains on the phosphoenzyme transition of Ca^<2+>-ATPase and a critical importance of the charged residues at the hinge of the P and N domains2011
- Author(s)
  Kazuo Yamasaki, Takashi Daiho, Stefania Danko, Hiroshi Suzuki
- Organizer
  2011 ASBMB Special Symposia Series 13th Na,K-ATPase and Related P-ATPases : Structure, Biology and Medicine
- Place of Presentation
  Pacific Grove, CA, USA
- Year and Date
  2011-10-01
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Critical importance of helix-loop conversions, length, and Actuator-domain junction structure of M2 in Ca^<2+>-ATPase for Ca^<2+> transport2011
- Author(s)
  Takashi Daiho, Stefania Danko, Kazuo Yamasaki, Hiroshi Suzuki
- Organizer
  2011 ASBMB Special Symposia Series 13th Na, K-ATPase and Related P-ATPases : Structure, Biology and Medicine
- Place of Presentation
  Pacific Grove, CA, USA
- Year and Date
  2011-09-29
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体Ca^<2+>ポンプにおけるエネルギー共役;細胞質領域アクチュエータードメインと膜貫通ヘリックスとの連結部分の役割2011
- Author(s)
  大保貴嗣、Stefania Danko、山崎和生、鈴木裕
- Organizer
  日本生体エネルギー研究会
- Place of Presentation
  京都
- Year and Date
  2011-12-20
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Mechanism of Ca^<2+>-ATPase revealed by mutations, kinetics, and development of stable analogs of phosphorylated intermediates2011
- Author(s)
  Hiroshi Suzuki, Takashi Daiho, Kazuo Yamasaki, Stefania J.Danko
- Organizer
  2011 ASBMB Special Symposia Series 13th Na, K-ATPase and Related P-ATPases : Structure, Biology and Medicine
- Place of Presentation
  Pacific Grove, CA, USA(招待講演)
- Year and Date
  2011-09-28
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Ca^<2+>ポンプの分子作動機構 : 部位特異的変異およびリン酸化中間体アナログの開発と構造解析による理解2009
- Author(s)
  鈴木裕
- Organizer
  日本薬学会第129年会
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] Ca^<2+>ポンプの分子作動機構 : 部位特異的変異およびリン酸化中間体アナログの開発と構造解析による理解2009
- Author(s)
  鈴木裕
- Organizer
  日本薬学会第129年会(招待講演)
- Place of Presentation
  京都
- Year and Date
  2009-03-27
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] Ca^<2+>ポンプの輸送機構-部位特異的変異およびリン酸化中間体アナログの開発と構造解析による理解2008
- Author(s)
  鈴木裕
- Organizer
  日本生体エネルギー研究会第34回討論会
- Place of Presentation
  東京
- Year and Date
  2008-11-07
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] Roles of the A domain and its linkers of sarco(endo)plasmic reticulum Ca^<2+> pump for processing the phosphorylated intermediates and Ca^<2+> release2008
- Author(s)
  Hiroshi Suzuki
- Organizer
  12th International ATPase Conference(招請講演)
- Place of Presentation
  デンマーク・オーフス
- Year and Date
  2008-08-06
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] Roles of the A domain and its linkers of sarco(endo)plasmic reticulum Ca^<2+> pump for processing the phosphorylated intermediates and Ca^<2+> release2008
- Author(s)
  Hiroshi Suzuki
- Organizer
  12th International ATPase Conference
- Place of Presentation
  デンマーク・オーフス
- Year and Date
  2008-08-06
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] Ca^<2+>ポンプの輸送機構-部位特異的変異およびリン酸化中間体アナログの開発と構造解析による理解2008
- Author(s)
  鈴木裕
- Organizer
  日本生体エネルギー研究会第34回討論会(招請講演)
- Place of Presentation
  東京
- Year and Date
  2008-11-17
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] Molecular mechanism of Ca^<2+>-ATPase and Darier disease caused by its defects2006
- Author(s)
  Hiroshi Suzuki
- Organizer
  国際会議 "Molecular Mechanism and Regulation in Cation Transport ATPases and Related Genetic Diseases" 特別講演
- Place of Presentation
  京都
- Year and Date
  2006-06-16
- Data Source
  KAKENHI-PROJECT-18370058
[Presentation] 筋小胞体カルシウムポンプのEP転換とカルシウム放出の共役機構におけるTyr122-hydrophobic clusterの役割
- Author(s)
  山崎　和生、Danko Stefania、大保　貴嗣、鈴木　裕
- Organizer
  日本生体エネルギー研究会　第40回討論会
- Place of Presentation
  愛媛
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] ナノディスクに組み込んだ筋小胞体Ca2+-ATPaseの活性に対する脂質ヘッドグループの影響の解析
- Author(s)
  山崎和生、Danko Stefania、大保貴嗣、鈴木裕
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] １分子蛍光観察によるCa2+-ATPaseの数と立体構造変化検出の試み
- Author(s)
  小島知樹、戸田啓太、山崎和生、Danko Stefania、小山洋幸、横田龍一、中山莉奈子、大保貴嗣、鈴木裕、政池知子
- Organizer
  日本生体エネルギー研究会　第40回討論会
- Place of Presentation
  愛媛
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Ca pump: Functional importance of structural changes in M2, and roles of long-range N-P domain electrostatic interactions and K+
- Author(s)
  鈴木　裕　（Hiroshi Suzuki）
- Organizer
  東京大学分子細胞生物学研究所セミナー
- Place of Presentation
  東京大学分子細胞生物学研究所、東京
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] A New Method for Ca2+-binding Measurement Applicable to a Small Quantity of Ca2+-ATPase: Transient E2P with Bound Ca2+ and Role of Leu119 on M2 in Ca2+-affinity Reduction and Ca2+ Release
- Author(s)
  Yamasaki Kazuo, Danko Stefania, Daiho Takashi, Suzuki Hiroshi
- Organizer
  Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease
- Place of Presentation
  The Netherlands
- Year and Date
  2014-08-30 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体Ca2+ポンプのM2ヘリックス：膜貫通部分と細胞質部分の連結領域の役割
- Author(s)
  大保貴嗣、山崎和生、Danko Stefania、鈴木裕
- Organizer
  第87回日本生化学会大会
- Place of Presentation
  京都
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Long-range Coupling between Catalytic and Transport Sites via Second Transmembrane Helix (M2) in E2P Hydrolysis and E2-E1 Transition of Ca2+-ATPase
- Author(s)
  Daiho Takashi, Yamasaki Kazuo, Danko Stefania, and Suzuki Hiroshi
- Organizer
  Na,K-ATPase and related transport ATPases: Structure, mechanism, cell biology, health and disease
- Place of Presentation
  The Netherlands
- Year and Date
  2014-08-30 – 2014-09-05
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] 筋小胞体Ca2+-ATPaseの第2膜貫通ヘリックス（M2）とロングレンジの共役
- Author(s)
  大保　貴嗣、山崎　和生、Danko Stefania、鈴木　裕
- Organizer
  日本生体エネルギー研究会　第40回討論会
- Place of Presentation
  愛媛
- Year and Date
  2014-12-11 – 2014-12-13
- Data Source
  KAKENHI-PROJECT-23370058
[Presentation] Ca2+-ATPaseの第2膜貫通ヘリックス（M2）とロングレンジの共役
- Author(s)
  Takashi Daiho, Yamasaki Kazuo , Danko Stefania, Suzuki Hiroshi
- Organizer
  第52回日本生物物理学会年会
- Place of Presentation
  札幌
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-23370058

1. DAIHO Takashi (90207267)

# of Collaborated Projects: 11 results

# of Collaborated Products: 56 results
2. YAMASAKI Kazuo (60241428)

# of Collaborated Projects: 9 results

# of Collaborated Products: 56 results
3. KANAZAWA Tohru (80028141)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
4. OHMIYA Hiroshi (80194299)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. KATO Sanae (80291061)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KAYA Shunji (90186023)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. HAYSHI Yutaro (10086556)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. TANIGUCHI Kazuya (40028204)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. IMAGAWA Toshiaki (20142177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 豊島近 (70172210)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 杉田有冶 (80311190)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 津田岳夫 (10345233)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 木寺詔紀 (00186280)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 安田哲 (80749896)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
15. MASAIKE Tomoko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. MINOWA Osamu

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
17. DANKO Stefania

# of Collaborated Projects: 1 results

# of Collaborated Products: 34 results
18. 権藤洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SUZUKI Hiroshi 鈴木 裕

鈴木 裕

Research Projects

Research Products

Co-Researchers

P-type pump ; Molecular basis of energy coupling and carcinogenesis caused by defectsPrincipal Investigator

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Molecular basis of P-type ion pumps and diseases caused by pump defects.Principal Investigator

Principal Investigator

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Molecular Mechanism of Endoplasmic and Golgi Cation Pumps and Diseases Caused by Their DefectsPrincipal Investigator

Principal Investigator

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Mechanism in Energy Transduction of Ca^<2+> Pump and Molecular Basis of Related Genetic DiseasesPrincipal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Structure and Function of Sarco(endo)plasmic Reticulum Ca^<2+>-ATPase and Mechanism of Darier's Diseases Caused by its AbnormalityPrincipal Investigator

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Research on molecular mechanism of sarcoplasmic reticulum Ca^<2+>-ATPase with site-directed mutagenesisPrincipal Investigator

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Studies on Structure and Function of the ATP-Binding sites of the Sarcoplasmic Reticulum Calcium Pump.Principal Investigator

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SUZUKI Hiroshi 鈴木裕

鈴木裕