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HAGA Tatsuya  芳賀 達也

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… Alternative Names

芳賀 逹也  ハガ タツヤ

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Researcher Number 30011646
Other IDs
Affiliation (based on the past Project Information) *help 2003 – 2008: 学習院大学, 理学部, 教授
1998: 東京大学, 医学係研究科, 教授
1997: University of Tokyo, Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授
1988 – 1997: 東京大学, 医学部, 教授
1991 – 1996: University of Tokyo, Faculty of Medicine Professor, 医学部(医), 教授 … More
1989: Institute of Brain Research, Professor, 医学部(医), 教授
1988: 東京大学, 医学部脳研生化学, 教授
1987: 浜松医科大学, 医学部, 助教授
1986 – 1987: 浜松医科大学, 助教授
1986: 浜松医大, 医学部, 助教授
1985: 浜松医科大学, 医, 助教授 Less
Review Section/Research Field
Principal Investigator
Neurochemistry/Neuropharmacology / Biological Sciences / General physiology / Neuroscience in general / 広領域
Except Principal Investigator
医学一般 / General pharmacology / Biological Sciences / General medical chemistry / Biological pharmacy
Keywords
Principal Investigator
ムスカリン受容体 / GTP結合蛋白質 / レセプター / ムスカリン性アセチルコリン受容体 / G蛋白質 / 再構成 / アセチルコリン受容体 / Gタンパク質共役受容体 / 細胞内移行 / G Protein … More / Receptor / Gタンパク質 / リン酸化 / レセプタ- / Acetylcholine Receptor / Muscarinic Receptor / 脱感受性 / Gタンパク質共役受容体キナーゼ / 受容体 / アセチルコリン / ムスカリン / 受容体キナーゼ / 神経伝達物質 / TRNOE / 膜タンパク質 / 結晶構造 / リサイクリング / オーファン受容体 / 高親和性コリントランスポーター / シグナル伝達 / 神経科学 / 生理活性 / 蛋白質 / 薬理学 / ムスカリン受容体アセチルコリン受容体 / GTP結合制御蛋白質 / リセプター / G-蛋白質 / ドパミンD2受容体 / 蛋白質精製法 / アフィニティ-クロマトグラフィ- / バキュロウイルス / Protein Purification / Affinity Chromatography / GTP-Binding Protein / Baculovirus / BARK / キナーゼ / muscarinic receptor / acetylcholine receptor / G protein / phosphorylation / desensitization / G protein-coupled receptor / G protein-coupled receptor kinase / sequestration / 高次構造 / 大量発現 / 伝達物質 / Conformation / Large-Scale Purification / Transmitter / Acetylcholine / Muscarine / ドパミン受容体 / エンドサイトーシス / G Protein-Coupled Receptor / Desensitization / G Protein-Coupled Receptor Kinases / Dopamine Receptor / Internalization / ピレンゼピン / プロテインキナ-ゼC / Muscarinic receptor / Acetylcholine receptor / GTP binding protein / Pirenzepine / Reconstitution / Phosphorylation / Protein kinase C … More
Except Principal Investigator
神経回路形成 / シナプス / 受容体 / 細胞骨格蛋白質 / 神経伝達物質 / 細胞情報伝達 / 蛋白質燐酸化反応 / リン酸化 / G蛋白質 / イオンチャネル / 百日咳毒素 / 痛覚 / タキキニン / ガン遺伝子 / キメラcDNA / オピオイド受容体 / 情報伝達 / ムスカリン受容体 / GTP結合蛋白質 / 細胞膜受容体 / cDNAクローニング / NDPキナーゼ / ホスホリパーゼC / がん遺伝子 / 情報伝達機構 / 興奮性アミノ酸 / 鎮痛 / 非ペプチド性タキキニン拮抗薬 / 低分子量G蛋白質 / ガラニン / ペプチダーゼ阻害剤 / 脊髄切片 / 神経活動 / 回路網形成 / 神経特異的遺伝子 / 細胞接着因子 / シナプス形成 / 嗅覚レセプター / Gタンパク質 / 匂い / 遺伝子発現制御 / プロスタグランジン受容体 / G蛋白共役型受容体 / インターロイキン2受容体 / ミッドカイン / ペイシジン / 自己免疫性疾患 / ミドカイン / ベイシジン / 自己免疫生疾患 / 膜インターフェイス / 生命秩序 / ソフトな分子間相互作用 / 膜タンパク質 / シグナル伝達 / 物質輸送 / 核磁気共鳴法(NMR) / X線結晶構造解析 / ソフトな相互作用 / 分子間相互作用 / 視細胞 / 嗅細胞 / 味細胞 / リポソーム / サイクリックAMP / サイクリックGMP / ニューロン間の選択的結合 / ニューロン・グリア間認識 / シナプス機能発現と蛋白分子 / プロテインライブラリー / ニューロン・グリア分化の遺伝的制御 / 脳の形態形成と遺伝子発現 / 神経回路形成の分子機構 / ニューロン間選択的結合の分子機構 / ニューロン・グリア間認識の分子機構 / シナプス機能発現の分子機構 / 神経系機能蛋白質の超微量検出と同定 / 興奮収縮連関 / パッチクランプ法 / アセチルコリン / リセプター / ホスホランバン / エクオリン / X線回析法 / ミトコンドリア / 細胞内情報 / アデニレートシクラーゼ / 単クローン抗体 / 免疫グロブリン / バキュロウィルス / 免疫ブロッティング / 単クロ-ン抗体 / cDNAクロ-ニング / ホスホリパ-ゼC / ウェスタンブロッティング / ムスカリン性アセチルコリン受容体 / GTP-binding protein / Monoclonal Antibody / cDNA Cloning / Immunoglobulin / Phospholipase C / Pertussis Toxin / Baculovirus / Muscarinic Acetylcholine Receptor / 3量体G蛋白質 / G蛋白質共役型受容体 / 受容体キナーゼ / PI-3-キナーゼ / ワ-トマニン / 蛋白質チロシンリン酸化 / NOPキナーゼ / ワートマニン / 細胞分化 / ホスホリパーゼD / ADPボシル化 / レチノイン酸 / ビタミンD_3 / heterotrimeric G proteins / cell differentiation / protein tyrosine phosphorylation / wortmannin / PI-3-kinase / phospholipase / betagamma-subunit of G protein / receptor kinase / GTP結合タンパク質 / セカンドメッセンジャー / 効果器 / GTP-binding proteins / Second messengers / Membrane receptors / Ion channels / Effectors / Phosphorylation / Signal transduction Less
  • Research Projects

    (26 results)
  • Research Products

    (60 results)
  • Co-Researchers

    (70 People)
  •  Molecular soft interactions regulating membrane-interface activities in living systems

    • Principal Investigator
      AKUTSU Hideo
    • Project Period (FY)
      2003 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Osaka University
  •  G Protein-Coupled Receptors as Cell SensorsPrincipal Investigator

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      2003 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Gakushuin University
  •  細胞膜情報交換系の構造、機能解析と個体レベルでの役割

    • Principal Investigator
      ICHIKAWA Atsushi
    • Project Period (FY)
      1998
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (A)
    • Research Institution
      Kyoto University
  •  神経細胞におけるGタンパク質βγサブユニット・MAPキナーゼ・遺伝子発現系

    • Principal Investigator
      東原 和成
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Phosphorylation and Desensitization of G Protein-Coupled ReceptorsPrincipal Investigator

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      1996 – 1997
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      University of Tokyo
  •  Conformation of the Muscarinic Acetylcholine ReceptorPrincipal Investigator

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Neuroscience in general
    • Research Institution
      University of Tokyo
  •  神経活動による遺伝子応答

    • Principal Investigator
      三木 直正
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Osaka University
  •  The roles of heterotrimeric GTP-binding proteins in signal transduction

    • Principal Investigator
      KATADA Toshiaki
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo (Faculty of Pharmaceutical Sciences)
  •  Phosphorylation and desensitization of G protein-coupled receptors : Regulation by G protein betagamma subunits.Principal Investigator

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      UNIVERSITY OF TOKYO
  •  痛覚を伝える一次求心性線維の伝達物質と情報伝達機構

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  Physiological Roles of Heterotrimeric G-proteins in Signal Transduction

    • Principal Investigator
      UI Michio
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      Biological pharmacy
    • Research Institution
      The Institute of Physical and Chemical Research (RIKEN)
      The University of Tokyo
  •  痛覚を伝える一次求心性線維の伝達物質と情報伝達機構

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  シナプス機能発現の分子機構

    • Principal Investigator
      宮本 英七
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  Development of procedures to knock out the function of intracellular proteins by expression of cDNAs encoding specific antibodies.

    • Principal Investigator
      NUKADA Toshihide
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      General medical chemistry
    • Research Institution
      Tokyo University
  •  シナプス機能発現の分子機構

    • Principal Investigator
      宮本 英七
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  Development of Purification Methods of G Protein- Linked ReceptorsPrincipal Investigator

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      1989 – 1991
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      General physiology
    • Research Institution
      University of Tokyo, Faculty of Medicine
  •  心筋細胞の興奮・収縮機構

    • Principal Investigator
      多田 道彦
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Osaka University
  •  シナプス機能発現の分子機構

    • Principal Investigator
      宮本 英七
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kumamoto University
  •  トランスメンブランコントロールにおけるGTP結合蛋白質の役割

    • Principal Investigator
      UI Michio
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  神経系形成の分子機構

    • Principal Investigator
      佐武 明
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      医学一般
    • Research Institution
      Niigata University
  •  運動系における受容体作用の分子機構Principal Investigator

    • Principal Investigator
      芳賀 達也
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Hamamatsu University School of Medicine
  •  Structure, function and regulation of muscarinic acetylcholine receptorsPrincipal Investigator

    • Principal Investigator
      HAGA Tatsuya
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      広領域
    • Research Institution
      The University of Tokyo
      Hamamatsu University School of Medicine
  •  受容分子からイオンチャネルへの情報伝達

    • Principal Investigator
      栗原 堅三
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Hokkaido University
  •  ムスカリン性アセチルコリン受容体の機能再構成Principal Investigator

    • Principal Investigator
      芳賀 逹也
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Hamamatsu University School of Medicine
  •  神経系進化の分子的・細胞生物学的研究

    • Principal Investigator
      黒川 正則
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      医学一般
    • Research Institution
      The University of Tokyo
  •  ムスカリン性アセチルコリン受容体の機能再構成Principal Investigator

    • Principal Investigator
      芳賀 逹也
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Hamamatsu University School of Medicine

All 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book Patent

  • [Book] Encyclopedia of Neuroscience(G Protein-coupled receptor (Metabotropic receptor) )2008

    • Author(s)
      Hashimoto, Y. and Haga, T.
    • Total Pages
      6
    • Publisher
      Springe-Verlag
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] Muscarinic acetylcholine receptor, in"Handbook of Neurochemistry and Molecular Neurobiology, 3<rd>^ ed., edited by Mikoshiba, K.2008

    • Author(s)
      Ichiyama, S., and Haga, T.
    • Publisher
      Springer Publishers, New York
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] Springer Publishers2008

    • Author(s)
      Ichiyama, S., and Haga, T.,
    • Publisher
      Muscarinic acetylcholine receptor, in Handbook of Neurochemistry and Molecular Neurobiology, 3rd ed., edited by Mikoshiba, K.,
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] Ligand screening system using fusion proteins of G protein-coupled receptors with G protein a subunits2007

    • Author(s)
      Suga, H., and Haga, T.,
    • Publisher
      Neurochemistry International
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] 生物物理学ハンドブック IV2007

    • Author(s)
      佐藤元康,芳賀達也,石渡信一,桂勲,桐野豊,美宅成樹編
    • Publisher
      朝倉書店
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] G Protein-Coupled Receptors(Structure, Function, and Ligand Screening)2006

    • Author(s)
      Haga, T., Takeda, S., ed.
    • Total Pages
      315
    • Publisher
      CRC Press, Taylor & Francis Group
    • Data Source
      KAKENHI-PROJECT-15083101
  • [Book] Receptor biochemistry, in proteins, from analytics to structural genomics (ed.by R. A. Meyer)( Vol. 2)2006

    • Author(s)
      Haga, T., Kameyama, K.
    • Publisher
      Wiley-VCH
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] Screening of ligands for human GPCRs by the use of receptor-Gα fusion proteins, in "G protein-coupled receptors: structure, function, and ligand screening"2006

    • Author(s)
      Haga, T. and Takeda, S., Haga, T. and Takeda, S.,
    • Publisher
      Haga, T. and Takeda, S., CRC Press, Taylor & Francis Group
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Book] Haga, T. and Takeda, S.

    • Author(s)
      Furukawa, H., Hamada, T., Hirota, H., Ishigur, M., and Haga, T.,
    • Publisher
      Determination of steric structure of muscarinic ligands bound to muscarinic acetylcholine receptors: approaches by TRNOE (transferred nuclear overhauser effect), in "G protein-coupled receptors: structure, function, and ligand screening"
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris2009

    • Author(s)
      Yurugi-Kobayashi,T. Asada, H., Shiroishi, M., Shimamura, T., Funamoto, S., Katsuta, N., Ito, K., Sugawara, T., Tokuda, N., Tsujimoto H., Murata, T., Nomura, N., Haga, K., Haga, T., Iwata, S., and Kobayashi, T.
    • Journal Title

      Biochem. Biophys. Res. Commun Mar ; 6 : 380(2)

      Pages: 271-276

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Comparison of functional non-glycosylated GPCRs expression in Pichia pastoris.2009

    • Author(s)
      Yurugi-Kobayashi T, Asada H, Shiroishi M, Shimamura T, Funamoto S, Katsuta N, Ito K, Sugawara T, Tokuda N, Tsujimoto H, Murata T, Nomura N, Haga K, Haga T, Iwata S, Kobayashi T.,
    • Journal Title

      Biochem. Biophys. Res. Commun 380

      Pages: 271-276

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Muscarinic M4 receptor recycling. requires a motif in the third intracellular loop2008

    • Author(s)
      Hashimoto, Y., Morisawa, K., Saito, H・, Jojima, E・, Yoshida, N・and Haga, T.
    • Journal Title

      The Joumal of Pharmacology and Experimental Therapeutics 325

      Pages: 1-7

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Differential rate constants of racemization of aspartyl and asparaginyl residues in human alpha A-crystallin mutants2008

    • Author(s)
      Nakamura T, Sakai M, Sadakane Y, Haga T, Goto Y, Kinouchi T, Saito T, Fujii N.,
    • Journal Title

      Biochim. Biophys. Acta. 1784

      Pages: 1192-1199

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Muscarinic M4 receptor recycling requires a motif in the third intracellular loop.2008

    • Author(s)
      Hashimoto Y, Morisawa K, Saito H, Jojima E, Yoshida N, Haga T.,
    • Journal Title

      J. Pharmacol. Exp. Ther. 325

      Pages: 947-953

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Differential rate constants of racemization of aspartyl and asparaginyl residues in human alpha A-crystallin mutants2008

    • Author(s)
      Nakamura, T., Sakai, M., Sadakane, Y., Haga, T., Goto, Y., Kinouchii, T., Saito T, and Fujii N.
    • Journal Title

      Biochim. Biophys. Acta Sep ; 1784(9)

      Pages: 1192-1199

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Muscarinic M4 receptor recycling requires a motif in the third intracellular loop2008

    • Author(s)
      Hashimoto Y, Morisawa K, Saito H, Jojima E, Yoshida N, and Haga T.
    • Journal Title

      J. Pharmacol. Exp. Ther Jun ; 325(3)

      Pages: 947-953

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Ligand screening system using fusion proteins of G protein-coupled receptors with G protein α subunits2007

    • Author(s)
      Suga, H. and Haga, T.
    • Journal Title

      Neurochemisttry International 51

      Pages: 140-164

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Synthesis and Biological Evaluation of Boronic Acid Containing cis-Stilbenes as Apoptotic Tubulin Polymerization Inhibitors2006

    • Author(s)
      Nakamura, H. *, Kuroda, H., Saito, H., Suzuki, R., Yamori, T., Maruyama, K. and Haga, T.
    • Journal Title

      Chem. Med. Chem. 1

      Pages: 729-740

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] 5-oxo-eicosatetraenoic acid-induced chemotaxis : identification of a responsible receptor hGPCR48 and negative regulation by G protein G_<12/13>2006

    • Author(s)
      Koike, D., Obinata, H., Yamamoto, A., Takeda, S., Komori, H., Nara, F., Izumi, T., Haga, T.
    • Journal Title

      J. Biochem. 139

      Pages: 543-549

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Clathrin requirement for phosphorylation and internalization of β_2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2)2006

    • Author(s)
      Mangmool, S., Haga, T., Kobayashi, H., Kim, K.-M., Nakatya, H., Nishida, M., Kurose, H.
    • Journal Title

      J. Biol. Chem. 281

      Pages: 31940-31949

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] The structure of the third intracellular loop of the muscarinic acetylcholine receptor M2 subtype2006

    • Author(s)
      Ichiyama, S., Oka, Y., Haga, K., Kojima, S., Tateichi, Y., Shirakawa, M., and Haga, T.,
    • Journal Title

      FEBS Letters 580

      Pages: 23-26

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] 5-oxo-eicosatetraenoic acid-induced chemotaxis: identification of a responsible receptor hGPCR48 and negative regulation by G protein G12/132006

    • Author(s)
      Koike, D., Obinata, H., Yamamoto, A., Takeda, S., Komori, H., Nara, F., Izumi, T. and Haga, T.,
    • Journal Title

      J. Biochem. 139

      Pages: 543-549

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Clathrin requirement for phosphorylation and internalization of beta2-adrenergic receptor by G protein-coupled receptor kinase 2 (GRK2),2006

    • Author(s)
      Mangmool, S., Haga, T., Kobayashi, H., Kim, K.-M., Nakatya, H., Nishida, M. m and Kurose,H. *,
    • Journal Title

      J. Biol. Chem 281

      Pages: 31940-31949

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Synthesis and biological evaluation of boronic acid containing cis-stilbenes as apoptotic tubulin polymerization inhibitors2006

    • Author(s)
      Nakamura, H., Kuroda, H., Saito, H., Suzuki, R., Yamori, T., Maruyama, K., Haga, T.
    • Journal Title

      Chem. Med. Chem. 1

      Pages: 729-740

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] The structure of the third intracellular loop of the muscarinic acetylcholine receptor M_2 subtype2006

    • Author(s)
      Ichiyama, S., Uka, Y., Haga, K., Kojima, S., Tateichi, Y., Shirakawa, M., Haga, T.
    • Journal Title

      FEBS Letters 580

      Pages: 23-26

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Klavier (klv), a novel hypernodulation mutant of Lotus japonicus affected in vascular tissue organization and floral induction2005

    • Author(s)
      Oka-Kira, E., Tateno, K., Miura, K., Haga, T., Hayashi, M., Harada, K., Sato, S., Tabata, S., Shikazono, N., Tanaka, A., Watanabe, Y., Fukuhara, I., Nagata, T., and *Kawaguchi, M.,
    • Journal Title

      The Plant Journal 44

      Pages: 505-515

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Pivotal function for cytoplasmic protein FROUNT in CCR2-mediated monocyte chemotaxis2005

    • Author(s)
      Terashima, Y., Onai, N., Murai, M., Enomoto, M., Poonpiriya, V., Hamada, T., Motomura, K., Suwa, M., Ezaki, T., Haga, T., Kanegasaki, S., and Matsushima, K.,
    • Journal Title

      Nature Immunology 6

      Pages: 827-835

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Inhibitory role of endophilin 3 in receptor-mediated endocytosis2004

    • Author(s)
      Sugiura, H., Iwata, K, Matsuoka, M., Hayashi, H., Takemiya, T., Yasuda, S., Ichikawa, M., Yamauchi, T., Mehlen, P., Haga, T., Yamagata, K.
    • Journal Title

      J.Biol.Chem. 279

      Pages: 23343-23348

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Production of N-lauroylated G protein α-subunit in Sf9 insect cell : the type of N-acyl group of G_α influences G protein-mediated signal transduction2004

    • Author(s)
      Hashimoto, Y., Matsuda, T., Matsuura, Y., Haga, T., Fukuda, Y.
    • Journal Title

      J.Biochem. 135

      Pages: 319-329

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Effects of partial agonists and Mg^<2+> ions on the interaction of M_2 muscarinic acetylcholine receptor and G protein G_α_<i1>, subunit in the M_2-Gα_<i1> fusion protein2004

    • Author(s)
      Zhang, Q., Okamura, M., Guo, Z.-D., Niwa, S., Haga, T.
    • Journal Title

      J.Biochem. 135

      Pages: 589-596

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] The receptor-Gαfusion protein as a tool for ligand screening : a model study using nociceptin receptor-Gαi2 fusion protein.2004

    • Author(s)
      Takeda, S., Okada, T., Okamura, N., Haga, T., Isoyama-Tanaka, J., Kuwahara, H., Minamino, N.
    • Journal Title

      J. Biochem., 135

      Pages: 597-604

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Stimulation of intracellular calcium increases and prostaglandin E_2 generation in chinese hamster ovary cells expressing receptor-G_α_<16> fusion proteins2004

    • Author(s)
      Suga, H., Takeda, S., Haga, T., Okamura, M., Takao, K., Tatemoto, K.
    • Journal Title

      J.Biochem. 135

      Pages: 605-613

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Low pH facilitates uptake of proteins by cells through a non-endocytic pathway.2004

    • Author(s)
      Motizuki, M., Takei, T., Tasaka, K., Yokota, S., Kojima,S., Haga, T., and Tsurugi, K.,
    • Journal Title

      J. Biochem. 135

      Pages: 713-719

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Effects of partial agonists and Mg2+ ions on the interaction of M2 muscarinic acetylcholinereceptor and G protein Gαi1 subunit in the M2-Gαi1 fusion protein2004

    • Author(s)
      Zhang, Q., Okamura, M., Guo, Z-D., Niwa, S., and Haga, T.
    • Journal Title

      J. Biochem 135

      Pages: 589-596

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Stimulation of increases in intracellular calcium and prostaglandin E2 generation in Chinese hamster ovary cells expressing receptor-Gα16 fusion proteins.2004

    • Author(s)
      Suga, H., Takeda, S., Haga, T., Okamura, M., Takao, K., and Tatemoto, K.
    • Journal Title

      J. Biochem., 135

      Pages: 605-613

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Inhibitory role of endophilin 3 in receptor-mediated endocytosis.2004

    • Author(s)
      Sugiura, H., Iwata, K., Matsuoka, M., Hayashi, H., Takemiya, T., Yasuda, S., Ichikawa, M., Yamauchi, T., Mehlen, P., Haga, T., and Yamagata, K.,
    • Journal Title

      J. Biol. Chem., 279

      Pages: 23343-23348

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] The Receptor-G_α fusion protein as a tool for ligand screening : a model study using a nociceptin receptor-G_α_<i2> fusion protein2004

    • Author(s)
      Takeda, S., Okada, T., Okamura, N., Haga, T., Isoyama-Tanaka, J., Kuwahara, H., Minamino, N.
    • Journal Title

      J.Biochem. 135

      Pages: 597-604

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Journal Article] Production of N-lauroylated G protein α-subunit in Sf9 insect cells: the type of N-acyl group of Gα influences G protein-mediated signal2004

    • Author(s)
      Hashimoto, Y., Matsuda, T., Matsuura, Y., Haga, T., and Fukada, Y.
    • Journal Title

      transduction, J. Biochem 135

      Pages: 319-329

    • Data Source
      KAKENHI-PROJECT-15083207
  • [Patent] 高親和性コリントランスポーター2007

    • Inventor(s)
      芳賀 達也 奥田 隆志
    • Industrial Property Rights Holder
      独立行政法人科学技術振興機構
    • Acquisition Date
      2007-09-28
    • Data Source
      KAKENHI-PROJECT-15083101
  • [Presentation] Regulator of G-protein Signaling (RGS) 2 may bind to the third intracellular loop of the M2 muscarinic acetylcholine receptor.2008

    • Author(s)
      Watanabae, T., Ichiyama, S., Haga, T.
    • Organizer
      日本農芸化学会
    • Place of Presentation
      名古屋/名城大学天白キャンパス
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Regulation of the high affinity choline transporter (CHT1) by ubiquitin ligase Nedd4-22008

    • Author(s)
      Yamada, H., Imajoh-Ohmi, S.and Haga, T.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego California, USA
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] The role of G protein-coupled receptor kinase 2 in internalization of muscarinic acetylcholine receptor M4 subtype2008

    • Author(s)
      Saito, K., Kakegai, R., Hashimoto, Y., Haga, T.
    • Organizer
      第81回日本薬理学会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] The high affinity choline transporter: topology and choline binding site as studied by site- directed mutagenesis.2008

    • Author(s)
      Urashima, K., Kubo, Y., Nishikawa, S., Nakamura, T., Hayashi, K., Yamada, H., Osawa, C., Okuda, T., Haga, T.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego California, USA
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] ヒトαB-クリスタリン変異体中のAsp, Asn 残基のラセミ化反応速度定数の解析と構造活性相関2007

    • Author(s)
      中村徹、酒井美世、定金豊、芳賀達也、後藤祐児、藤井紀子
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Experimental evidence for topology of the high affinity choline transporter (CHT1)2007

    • Author(s)
      Urashima, K., Kubo, Y., Yamada, H., Okuda, T., Haga, T.
    • Organizer
      第30回日本分子生物学会年会、第80回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] 高親和性コリントランスポ-タ-の負電荷アミノ酸の変異解析2007

    • Author(s)
      西川静枝、大澤千恵子、松田弘子、奥田隆志、芳賀達也
    • Organizer
      第80回日本薬理学会年会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] クラスリンはGタンパク質共役受容体キナ-ゼ2(GRK)の活性化に必須である2006

    • Author(s)
      Mangmool, S., 芳賀達也、西田基宏、黒瀬等
    • Organizer
      第79回日本薬理学会年会
    • Place of Presentation
      パシフィコ横浜
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Interaction of muscarinic M2 receptor with G protein Gai 1 subunit in their fusion protein expressed in Escherichia coli: the effect of expression level2006

    • Author(s)
      Ichiyama, S., Nemoto, R., Haga, T.
    • Organizer
      12th International Conference on Retinal Proteins第12回レチナ-ルタンパク質国際会議
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo, Japan
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Dynamin-dependent internalization and recycling of M4 muscarinic acetylcholine receptors: the role of the third intracellular loop.2006

    • Author(s)
      Hashimoto, Y., Morisawa, K., Saito, H., Jojima, E., Yoshida, N., and Haga, T..
    • Organizer
      12th International Conference on Retinal Proteins
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo, Japan
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Molecular characterization by mutagenesis of the high affinity choline transporter (CHT1)2006

    • Author(s)
      Haga, T., Okuda, T., Kaitsuka, C., Osawa , C., Nishiyama, N., Yamada, H., Nakamura, T., Hayashi, K, Ito, S., Hamano, T., Sato, M., Ushio, T., Nishikawa, S., Kubo, Y., Matsuda, H.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Effect of G protein βγ subunits on the interaction of the muscarinic acetylcholine receptor M2 or M4 subtype with G protein Gαi1 subunit2006

    • Author(s)
      Ichiyama, S., Nemoto, R., Tanabe, H., Okamura, M., Furukawa, H., and Haga, T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOB Congress
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Effect of G proteinβγsubunits on the interaction of the muscarinic acetylcholine receptor M2 or M4 subtype with G protein Gαi1 subunit2006

    • Author(s)
      Ichiyama, S., Nemoto, R., Tanabe, H., Okamura, M., Furukawa, H., Haga, T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOB Congress
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto, Japan)
    • Data Source
      KAKENHI-PROJECT-15083101
  • [Presentation] Topology model for the high-affinity choline transporter by site-directed chemical labeling2006

    • Author(s)
      Kubo, Y., Yamada, H., Okuda, T., Haga, T.
    • Organizer
      第28回日本生物学的精神医学会、第36回日本神経精神薬理学会、第49回日本神経化学会大会合同年会
    • Place of Presentation
      名古屋国際会議場
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Kinetic study of racemization at Asp58 and Asp151 residues in recombinant human αA-crystallin2006

    • Author(s)
      Nakamura T., Sadakane Y., Haga, T., Fujii, N.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] A riegion in the third intracellular loop is involved in the recycling of internalized muscarinic acetylcholine receptor M4 subtype2006

    • Author(s)
      Hashimoto, Y., Morisawa, K., Saito, H., Jojima, E., Yoshida, N., and Haga, T.
    • Organizer
      20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress
    • Place of Presentation
      Kyoto International Conference Hall, Kyoto, Japan
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Does the third intracellular loop of the muscarinic acetylcholine receptor have a rigid tertiary structure?2005

    • Author(s)
      Ichiyama, S., Oka, Y., Haga, K., Kojima, S., Tateishi, Y., Shirakawa, M., and Haga, T.
    • Organizer
      Gordon Research Conference (Second Messengers & Protein Phosphorylation)
    • Place of Presentation
      Biddeford, U.S. A.
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] ムスカリン性アセチルコリン受容体M4サブタイプのダイナミン依存的細胞内移行2005

    • Author(s)
      森澤加乃子、橋本祐一、斉藤宏幸、城島依里、吉田典弘、芳賀達也
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] ヒト-クリスタリンにおけるラセミ化部位の役割2005

    • Author(s)
      中村徹、酒井美世、定金豊、芳賀達也、後藤祐児、木野内忠稔、藤井紀子
    • Organizer
      第78回日本生化学会大会
    • Place of Presentation
      神戸国際会議場
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] Internalization and Recycling of Muscarinic Acetylcholine Receptor M2 and M4 Subtypes.2005

    • Author(s)
      Hashimoto, Y., Yoshida, N., Jojima, E., Saito, H., Morisawa, K., and Haga, T.
    • Organizer
      Gordon Research Conference (Second Messengers & Protein Phosphorylation)
    • Place of Presentation
      Biddeford, U.S. A.
    • Data Source
      KAKENHI-PROJECT-15083207
  • [Presentation] 大腸菌で発現させたムスカリン性アセチルコリン受容体細胞内第3ル-プの精製と構造機能解析2005

    • Author(s)
      市山進、岡良彰、小島修一、芳賀達也
    • Organizer
      2005年度日本農芸化学会大会
    • Place of Presentation
      札幌コンベンションセンタ-
    • Data Source
      KAKENHI-PROJECT-15083207
  • 1.  KATADA Toshiaki (10088859)
    # of Collaborated Projects: 5 results
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  • 2.  宮本 英七 (50109659)
    # of Collaborated Projects: 5 results
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  • 60.  西塚 泰美 (10025546)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 61.  倉智 嘉久 (30142011)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 62.  NODA Kouji
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 63.  ISHIDA Torao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 64.  TANAKA Masato
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 65.  SATO Showbu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 66.  FUJISAWA Tadami
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 67.  SASAKI Hiromi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 68.  町田 肇
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 69.  NOGUCHI Hajime
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 70.  野田 康二
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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