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OTSUKA Masanori  大塚 正徳

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Researcher Number 60013801
Affiliation (Current) 2022: 東京医科歯科大学, その他の部局等, 名誉教授
Affiliation (based on the past Project Information) *help 1994: Tokyo Medical and Dental University, School of Medicine, Professor emeritus, 医学部, 名誉教授
1986 – 1993: School of Medicine, Tokyo medical and dental Univ. Professor, 医学部, 教授
1986: Tokyo Medical & Dental Univ., Fac. of Medicine, Professor, 医学部, 教授
1985: 東京医科歯科大学, 医, 教授
Review Section/Research Field
Principal Investigator
General pharmacology / 応用薬理学・医療系薬学
Except Principal Investigator
General pharmacology / General physiology / 応用薬理学・医療系薬学 / Neurophysiology and muscle physiology / 医学一般 / 内科学一般
Keywords
Principal Investigator
GABA / 摘出脊髄標本 / タキキニン受容体 / タキキニン / ニューロキニンA / substance P / 痛覚 / サブスタンスP / アセチルコリン / P物質 … More / tachykinin receptor / 内耳有毛細胞 / 無髄C線維 / 内因性活性物質 / C線維応答 / CCK-8 / Spantide / 脊髄 / セロトニン / スパンタイド / acetylcholine / タキキニン拮抗薬 / tachykinin antagonist / Isk蛋白 / 味細胞 / 原索動物胚 / GABA_A受容体 / 痛みの伝達機構 / リン酸化 / ガン遺伝子 / キメラcDNA / G蛋白質 / ガラニン / 不活性化機構 / ペプチダーゼ阻害薬 / タキキニン受容体拮抗薬 / グルタミン酸 / 下行性抑制 / HPLC / isolated spinal cord preparation / serotonin / non-opioid analgesic / 侵害反射電位 / モルフィン / エンケファリン / GABA_Aの受容体 / K^+チャネル / H^+ / K^+ATPase / 膜電位依存性K^+チャネル / 嗅細胞 / プロトンポンプ / セリンプロテア-ゼ / タキキニン作動性神経 / 痛みの伝連達機構 / 情報伝達機構 / 興奮性アミノ酸 / 鎮痛 / 非ペプチド性タキキニン拮抗薬 / 低分子量G蛋白質 / オピオイド受容体 / ペプチダーゼ阻害剤 / 脊髄切片 / 新生ラット脊髄 / チオルファン / アクチノニン / 中枢神経 / 大脳初代培養 / スクリーニング / P物質拮抗物質 / 摘出脊髓標本 / 胃運動 / アドレナリン作動性神経 / ヘロデルミン / 3メチル1,2,3,4テトラハイドロイソキノリン / レゼルピン処置犬 / valosin / テトラハイドロイソキノリン / バゾプレシン / グルタミン酸レセプター / VIP / 含フッソアミノ酸 / I-メチルテトラヒドロイソキノリン / 抗利尿作用 / ATP / K^+チャンネル / 運動ニューロン / substanceK受容体 / 視細胞 / グルタミン酸キャリアー / cGMP結合タン白 / ベンゾジアゼピン受容体 / ベンゾジアゼピン拮抗薬 / 痛覚伝達 / 単シナプス反射 / アデノシン / アデノシンアンタゴニスト / セロトニンアンタゴニスト / アデノシンデアミナ-ゼ / 下降性抑制 / tachykinins / Descending inhibition / 分子モデリング / ヒスタミン / IM-9細胞 / PCR / ラジオレセプタ-アッセイ / 抗ムスカリン作用 / 神経可塑性 / 組織培養 / 大脳皮質 / シナプス伝達 / グルタミン酸受容体 / アセチルコリン受容体 / c-fos / phorbol ester / cーfos / Neural Plasticity / Glutamate Receptor / Acetylcholine Receptor / Tissue Culture / Substance P / Cerebral Cortex / Spinal Cord / P物質拮抗薬 / カプサイシン / 摘出脊髄-尾標本 / 摘出脊髄-知覚神経標本 / 摘出脊髄-伏在神経-皮フ標本 / 非麻薬性鎭痛薬 / 侵害反射 / メチオニン / ダイノルフィン / ナロキソン / Nociception / substance P antagonist / non-opioid analgesics / 摘出脊髄・尾標本 / ムスカリン受容体 / SP拮抗薬 / 伝達物質 / substance P,GABA / P,GABA / SP受容体 / 感覚系神経伝達物質 / 摘出脊髄-伏在神経標本 / 摘出脊髄-伏在神経-皮膚標本 / プロスタグランジン / isolated spinal cord-tail preparattion / descending inhibition / ニュ-ロキニンA / 摘出脊髄・伏在神経・皮膚標本 / 非麻薬性鎮痛薬 / 内因性ペプチド / セプタイド / NKー1型受容体 / 脊髄運動ニューロン / Isolated spinal cord preparation / neurokinin A / morphine / isolated spinal cord-nerve-skin preparation … More
Except Principal Investigator
トランスメンブランコントロール / 筋小胞体 / DHP結合蛋白質 / リアノジン結合蛋白質 / ATP合成酵素 / 蛋白架橋 / 低酸素環境 / ムスカリン性アエチルコリン受容体 / トランスメンブランコントロ-ル / ムスカリン性アセチルコリン受容体 / 創薬基礎科学 / カルシウムイオン / Cカイネース / サイクリックヌクレオチド / GTP結合蛋白質 / レセプター / 神経ペプチド / ガラニン / 受容体 / Galanin / Substance P / 細胞内情報伝達系 / 構造活性相関 / TRH / 神経伝達 / 共同研究の推進 / 研究情報の流通 / サ-キュラ-の発行 / 低酵素環境 / 分子薬理研究用プローブ / リード化合物 / 痛みの伝達 / Substance-P / 脊髄反射電位 / 視床 / 侵害受容ニューロン / 下向性抑制系 / 除痛 / 神経活性物質 / 神経伝達物質 / 神経制御物質 / 神経伝達物質受容体 / 神経栄養因子 / 神経活性アミン / 神経活性アミノ酸 / 脳腸ペプチド / 脳腸ホルモン / 進化 / 分泌 / 受容認識 / 情報伝達 / 病態 / 内因性神経活性物質 / 活性物質変容体 / 脳機能 / 痛覚系 / 内因性鎮痛系 / オピオイドペプチド / 神経系ー免疫系相互連関 / 痛みと自律系機能 / 痛みと情動系 / 複合膜の機能 / 膜電位依存性Caチャンネル / プロテインキナーゼC / 細胞増殖 / 細胞骨格 / 細胞変性 / P物質 / ガラニン(1-15) / ガラニンアゴニスト / ガラニン(1-15)受容体 / ガラニンアンタゴニスト / [D-Thr^6,D-Trp^<8,9>]-galanin(1-15)-ol / PACAP / ガラニン・アゴニスト / ガラニン・アンタゴニスト / 合成ペプチド / 化学合成 / ガラニン作用 / 特異抗体 / Galanin (1-15) / Receptor / (D-Thr^6,D-Trp^<8,9>)-galanin (1-15)-ol / Galanin (1-15) receptor / Galanin agonist / Galanin antagonist / 細胞内情報伝達 / 機能性蛋白質 / 機能探索子 / 創薬 / signal transduction / intracellular message system / molecular probe / ニューロキニンA / ニューロキニンB / ペプチド性神経伝達物質 / 受容体サブタイプ / ニューロキニンA,B / 神経伝達ペプチド / 構造と活性の相関 / 平滑筋収縮 / Neurokinin A / Neurokinin B / Active-conformation / Structure-Activity / relationships / Tachykinin-receptor / チトクローム / 酸化還元位 / CCK-8 / ノンスパイキングニューロン / 視視策上核 / 蝸牛有毛細胞 / 扁桃体内側核 / 松果体 / Cytochromes / Redox state / CCK-octapeptide / Non-spiking neurone / Oxytocin / Triphosphoinositide (TPI) / ソマトスタチン / マストパラン / キョートルフィン / タキキニン / 利尿ホルモン / 作用機序 / 女郎グモ毒 / GLP-1 / タヒキニン / トキニン / カルシトニン遺伝子関連ペプチド / ニューロテンシン / 脳Na利尿ペプチド / サブスタンスP / ニューロキニンK / VIP / エンケファリン / ネオキョートルフィン / ニューロメディン / Somatostatin / Mastoparan / Kyotorphin / Tachykinin / Natriuretic polypeptide Less
  • Research Projects

    (38 results)
  • Co-Researchers

    (93 People)
  •  痛みの伝達機構と内因性活性物質Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  受容体を中心とした新しい薬物開発の基礎研究

    • Principal Investigator
      鹿取 信
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Kitasato University
  •  中枢シナプスにおけるタキキニン伝達物質の不活性化機構に関する研究Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tokyo Medical and Dental University
  •  中枢神経系のタキキニン受容体サブタイプの研究とこれに基づいた薬物開発Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical and Dental University
  •  痛覚を伝える一次求心性線維の伝達物質と情報伝達機構Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  Establishment of the pharmacological sciences to elucidate the signal transduction system.

    • Principal Investigator
      HIDAKA Hiroyoshi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Nagoya University
  •  痛みの伝達機構と内因性活性物質Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  痛覚を伝える一次求心性線維の伝達物質と情報伝達機構Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  トランスメンブランコントロ-ルの機序

    • Principal Investigator
      遠藤 實
    • Project Period (FY)
      1991
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  A study on the developmental plasticity of neurons using isolated spinal cord and cultures visual cortex.Principal Investigator

    • Principal Investigator
      OTSUKA Masanori
    • Project Period (FY)
      1991 – 1993
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      Tokyo Medical and Dental University
  •  Joint study on design, synthesis and analysis of agonists and antagonists of galanin

    • Principal Investigator
      YANAIHARA Noboru
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      University of Shizuoka
  •  トランスメンブランコントロ-ルの機序

    • Principal Investigator
      遠藤 實
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  痛みの伝達機構と内因性活性物質Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1990
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Institution
      Tokyo Medical and Dental University
  •  A study of neural mechanisms of pain transmission in the rat spinal cordPrincipal Investigator

    • Principal Investigator
      OTSUKA Masanori
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      Tokyo Medical & Dental University
  •  A Study of tachykinin-mediated neural mechanisms in the spinal cord and development of tachykinin antagonists as analgesics and anti-allergic drugsPrincipal Investigator

    • Principal Investigator
      OTSUKA Masanori
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical & Dental University
  •  トランスメンブランコントロールの機序

    • Principal Investigator
      ENDO Makoto
    • Project Period (FY)
      1989
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  「脳・神経細胞におけるインパルス・シグナリングの分子機構」の推進

    • Principal Investigator
      吉岡 亨
    • Project Period (FY)
      1989 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Waseda University
  •  刺激によるイオンチャンネル機能の制御Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  刺激によるイオンチャネル機能の制御Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1988 – 1990
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  内因性神経活性物質の研究ー成果のとりまとめ

    • Principal Investigator
      吉田 博
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Osaka University
  •  生体の警告信号防御系の働きとその物質的基盤

    • Principal Investigator
      熊澤 孝朗
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      Neurophysiology and muscle physiology
    • Research Institution
      Nagoya University
  •  トランスメンブランコントロールの機序

    • Principal Investigator
      遠藤 實
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  刺激によるイオンチャンネル機能の制御Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1988
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Tokyo Medical and Dental University
  •  神経伝達物質の探索と類縁物質の化学的合成Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Tokyo Medical and Dental University
  •  内因性神経活性物質の研究

    • Principal Investigator
      吉田 博
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Osaka University
  •  生体調節系における脳腸ペプチドの役割

    • Principal Investigator
      KANNO Tomio
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      General physiology
    • Research Institution
      Hokkaido University
  •  トランスメンブランコントロール機構の基礎的研究

    • Principal Investigator
      遠藤 實
    • Project Period (FY)
      1987
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      The University of Tokyo
  •  Development of in vitro preparations for quantitative analysis of pain and screening of non-opioid analgesicsPrincipal Investigator

    • Principal Investigator
      OTSUKA Masanori
    • Project Period (FY)
      1987 – 1989
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      General pharmacology
    • Research Institution
      Tokyo Medical & Dental University
  •  疼痛のメカニズム

    • Principal Investigator
      高倉 公朋
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      The University of Tokyo
  •  神経伝達物質の探索と類縁物質の化学的合成Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Tokyo Medical and Dental University
  •  内因性神経活性物質の研究(総括班)

    • Principal Investigator
      吉田 博
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Osaka University
  •  トランスメンブランコントロール機構の基礎的研究

    • Principal Investigator
      遠藤 實
    • Project Period (FY)
      1986
    • Research Category
      Grant-in-Aid for Co-operative Research (B)
    • Research Field
      General pharmacology
    • Research Institution
      The University of Tokyo
  •  Studies on structure-activity relationship and intracellular signal transduction systems of neuropeptides

    • Principal Investigator
      KITO Shozo
    • Project Period (FY)
      1986 – 1988
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      内科学一般
    • Research Institution
      HIROSHIMA UNIVERSITY
  •  A study on sensory neurotransmitters using isolated spinal cord preparationsPrincipal Investigator

    • Principal Investigator
      OTSUKA Masanori
    • Project Period (FY)
      1986 – 1989
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      General pharmacology
    • Research Institution
      Tokyo Medical & Dental University
  •  神経伝達物質の探索と類縁物質の化学的合成Principal Investigator

    • Principal Investigator
      大塚 正徳
    • Project Period (FY)
      1985
    • Research Category
      Grant-in-Aid for Special Project Research
    • Research Institution
      Tokyo Medical and Dental University
  •  Paracrine secretion; its function, morphology and concept

    • Principal Investigator
      KANNO Tomio
    • Project Period (FY)
      1985 – 1986
    • Research Category
      Grant-in-Aid for Co-operative Research (A)
    • Research Field
      General physiology
    • Research Institution
      Hokkaido University
  •  Biochemical studies on novel neuropeptides, neurokinins

    • Principal Investigator
      MUNEKATA Eisuke
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      医学一般
    • Research Institution
      Institute of Applied Biochemistry, Univ. of Tsukuba
  •  Development of new types of non-opioid analgesicsPrincipal Investigator

    • Principal Investigator
      OTSUKA Masanori
    • Project Period (FY)
      1984 – 1986
    • Research Category
      Grant-in-Aid for Developmental Scientific Research
    • Research Field
      応用薬理学・医療系薬学
    • Research Institution
      Tokyo Medical & Dental University, Faculty of Medicine
  • 1.  KURIYAMA Kinya (20079734)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 2.  ENDO Makoto (50009990)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 3.  YANAGISAWA Mitsuhiko (90159252)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 4.  YANAIHARA Noboru (80046250)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 5.  YOSHIOKA Koichi (00143579)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 6.  栗山 煕 (40037495)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 7.  田中 千賀子 (20025571)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 8.  SUZUKI Hidenori (30221328)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 9.  MURAKOSHI Takayuki (60190906)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 10.  SAITO Koji (20002082)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 11.  高木 博司 (60025674)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 12.  遠藤 政夫 (40004668)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 13.  大久保 博晶 (20094089)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 14.  佐藤 昭夫 (60072980)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 15.  熊澤 孝朗 (20022775)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 16.  広部 雅昭 (20012594)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 17.  KANAZAWA Ichiro (30110498)
    # of Collaborated Projects: 3 results
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  • 26.  塩谷 弥兵衛 (60028347)
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  • 28.  KANNO Tomio (50009982)
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  • 29.  YAMASHITA Hiroshi (00030841)
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  • 30.  HISADA Mituhiko (70000768)
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  • 31.  SATOH Masamichi (80025709)
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  • 32.  MIYATA Yuhei (00014275)
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  • 33.  中西 重忠 (20089105)
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  • 34.  芳賀 達也 (30011646)
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  • 35.  堅田 利明 (10088859)
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  • 36.  杉本 哲夫 (90144352)
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  • 49.  TODA Noboru (50025590)
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  • 50.  MUNEKATA Eisuke (60072766)
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  • 52.  KITO Shozo (00010140)
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  • 53.  TOHYAMA Masaya (40028593)
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  • 57.  桐野 豊 (10012668)
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  • 58.  葛西 道生 (40022595)
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  • 59.  鈴木 英雄 (60063541)
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  • 61.  鹿取 信 (50050365)
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  • 70.  松尾 寿之 (50028685)
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  • 71.  TERAO Shinji
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  • 72.  BAUGHMAN Rob
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  • 73.  BAUGHMAN robert W.
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  • 74.  ROBERT Baugh
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  • 75.  J.CHRISTOPHE
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  • 76.  J.C.BROWN
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  • 77.  B.AMIRANOFF
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  • 78.  H.LABURTHE
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  • 79.  F.LEMBECK
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  • 80.  B.PERNOW
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  • 81.  T.HOKFELT
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  • 82.  CHRISTOPHE Jean
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  • 83.  AMIRAMOFF Brigitte
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  • 84.  LEMBECK Fred
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  • 85.  PERNOW Bengt
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  • 86.  HOKFELT Tomas
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    # of Collaborated Products: 0 results
  • 87.  BROWN John C.
    # of Collaborated Projects: 1 results
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  • 88.  BROWN J.C.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 89.  CHRISTOPHE J
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 90.  HOEKFELT T.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 91.  AMIRANOFF B.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 92.  藤野 政彦
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 93.  FUJINO Masahiko
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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