TAMAI Makoto 玉井信

… Alternative Names

王井信タマイマコト

五井信

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Researcher Number	90004720
External Links
Affiliation (based on the past Project Information) *help	2009 – 2011: Tohoku University, 大学院・医学系研究科, 名誉教授 2008: 東北大学, 医学系研究科, 名誉教授 2007: Tohoku University, Professor 2005 – 2007: 東北大学, 先進医工学研究機構, 教授 1999 – 2004: 東北大学, 大学院・医学系研究科, 教授 … More 1988 – 1998: 東北大学, 医学部, 教授 1996: 東北大学, 医学部, 助教授 1992 – 1993: 東北大学, 医学部・眼科, 教授 1991: Tohoku Univ. School of Med., 医学部附属病院, 教授 1990: 東北大学, 医学部・眼科, 教授 1987: 東北大学, 医学部(眼科), 教授 1986: 東北大, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Ophthalmology / Ophthalmology / Biomedical engineering/Biological material science Except Principal Investigator Ophthalmology / Ophthalmology / Neurophysiology and muscle physiology / 電子デバイス・機器工学 / 医学一般
Keywords	Principal Investigator 虹彩色素上皮細胞 / 網膜 / アデノ随伴ウイルスベクター / 遺伝子導入 / 移植 / 神経栄養因子 / transplantation / 網膜色素変性症 / 色素上皮細胞 / Retinitis pigmentosa … More / 硝子体手術 / 網膜色素上皮移植 / 加齢黄斑変性症 / 網膜色素上皮細胞 / bFGF / リポソーム / gene transfer / IPE / neurotrophic factors / 加齢黄斑変性 / 人工視覚 / サル / 人工網膜チップ / 一次視覚野 / 光遺伝学 / 視覚再生 / チャネルロドプシン / 視覚野 / 神経節細胞 / 遺伝子治療 / 空間周波数特性 / 波長感受性 / コントラスト感度 / 器官培養 / ラット / ビタミンA類 / オプシン / 分化 / ロドプシン / 固相酵素免疫測定法 / 免疫組織化学 / 遺伝子網膜変性症 / 網膜特異的cDNAクロ-ン / ロドプシン遺伝子 / 分子生物学 / 遺伝性網膜変性症 / Hereditary Retinal Degeneration / Retina specific cDNA clones / Rhodopsin gene / Molecular biology / 加令黄斑変性症 / 新生血管 / 網膜色素上皮細胞移植 / 硝子体サンプリング / 実験的網膜色素上皮障害 / 網膜色素上皮再生 / 病理組織学的検索 / 新生血管黄斑症 / 組織化学 / 加令黄斑症 / Age related macular degeneration / Neovascularization / Transplantation of retin at pigment epithelial cells / Vitreous surgery / Sampling of vitreous / Experimental damage of retinal pigment epithelium / Regeneration of retinal pigment epithelium / Histopatho logical study / 虹彩色素上皮移植 / 細胞凍結保存 / 培養色素上皮細胞 / 凍結保存 / コラーゲンゲル / 異種移植 / 細胞外基質 / ラミニン / グリシン / MRI / RPE / RPE transplantation / IPE transplantation / Cryopreservation / Age-related macular degeneration / 再生 / 視神経 / 坐骨神経 / ミュラー細胞 / regeneration / optic nerve / sciatic nerve / retina / retinal pigement epithelium / Muller cells / 虚血 / 虚血性眼底疾患 / 生理活性物質 / 細胞増殖因子 / グルタミン酸 / 興奮毒 / ischemia / retinal damage / cytokines / growth factors / glutamate / excitotoxicity / liposomes / 遺伝し導入 / サイトカイン / age related macular degeneration / 脳由来神経栄養因子 / アデノウイルス / iris pigment epithelial cells / adeno-associate virus vector / Brain derived neurotrophic factor / 網膜色素変性 / 細胞移植 / 虹彩色素上皮 / ウイルスベクター / age-related macular degeneration / Cell transplantation / Iris pigment epithelium / Adeno-associate virus / ビデオ蛍光眼底造影 / 画像処理 / ビデオ録画 / デジタル・サブトラクション / ビデオ蛍光眼底撮影 / Fluorescein video-angiography, / Image processing, / Video tape recording / Digital subtraction … More Except Principal Investigator 網膜色素変性症 / Retina / ロドプシン / ロドプシン遺伝子 / 網膜 / 分子生物学 / 網膜変性 / ウサギ / SSCP / ペリフェリン / RDS / Retinitis Pigmentosa / Peripherin / RDS遺伝子 / RDS gene / 視細胞外節 / レチノール脱水素酵素 / cDNA / Retinitis pigmentosa / 網膜構築 / 視神経再生 / 視覚機能分化 / 層形成 / 人工眼 / 義眼 / 3次元集積化技術 / 集積回路 / 実装技術 / 医療 / 半導体 / 医工学 / 有機アニオントランスポーター / organic anion transporting polypeptide / oatp / 網膜組織上皮細胞 / 毛様体無色素上皮細胞 / 角膜上皮細胞 / 甲状腺ホルモン / 視神経繊維 / チャネルロドプシン-2 / 視細胞変性 / 神経節細胞 / ポジトロン断層法 / 脳ブドウ糖消費量 / 脳循環 / 脳硬塞 / 老人性痴呆 / 多発硬塞性痴呆 / アルツハイマ-病 / 脳代謝 / 脳血流量 / 視覚失認 / ポジトロンエミツショントモグラフィ- / 視覚障害 / positron emission tomography / cerebral metabolic rate for glucose / cerebral blood flow / cerebral infarction / Seuile dementia / Multi infarct dementia / Alzheimcrs disease / Cerebral mefabolism / 常染色体優性網膜色素変性 / ペリフェリン1RDS / rdsマウス / 網膜特異的蛋白質 / MEKA蛋白質 / PCR法 / SSCP法 / Autosomal Dominant Retinitis Pigmentosa / Rhodopsin / MEKA / 脳回転状脈経網膜萎縮症 / OAT遺伝子 / アセタグラミド / X染色体劣性眼白子症 / 脳回転状脈絡網膜萎縮症 / アセタゾラミド / X染色体劣勢眼白子症 / Ornithine aminotransferase / オルニチン・アミノトランスフェラーゼ / 黄斑浮腫 / Rhodopsin Gene / Gyate ATrophy / OAT gene / Acetazolamicle / X-linked Ocrlan Albimism / ストレス蛋白 / 絶対緑内障 / 眼細胞 / 内節 / フィッシャーラット / 高体温 / 加齢 / 熱ショック / 視細胞内節 / HSP70 / 角膜 / 円錐角膜 / 水疱性角膜症 / 絶性緑内障 / Stress protein / Absolute glaucoma / Photoreceptor cell / Inner segment / Fisher-344 rat / Hyperthermia / aging / 視神経 / 移植 / 再生 / 細胞分化 / アミノ酸受容体 / 色素上皮 / 成長因子 / 機能回復 / 組織構築 / 神経栄養因子 / Optic nerve / Transplantation / Regeneration / Cell differentiation / Amino acid receptor / Retinal pigment epithelium / Trophic factor / c2DNA / 一次構造 / 遺伝子 / 光受容細胞 / 視細胞 / retinol dehydrogenase / primary structure / gene / photoreceptor cells / retinitis pigmentosa / ペリフェリン・RDS遺伝子 / cGMPホスホジエステラーゼ遺伝子 / 連鎖解析 / 杆体錐体変性 / 錐体杆体変性 / peripherin / rhoclopsin gene / limkage analysis / 脈絡膜血流 / 短毛様体神経 / 逆伝導性血管拡張 / 副交感神経性血管拡張 / サプサイシン / カプサイシン / 脈絡膜循環 / 副交感神経 / 感覚神経 / 血管拡張 / choroidal blood flow / short ciliary nerve / antidromic vasodilatation / parasy mpathetic vasodilatation / capsaicin / cat / ロービジョン / 視機能評価 / 緑内障 / 糖尿病網膜症 / 網膜色素変性 / 加齢黄斑変性 / Low vision / Visual function / Retinitis pogmentosa / Claucoma / Diabetic retinopathy / 人工網膜 / 三次元積層化技術 / retinal prosthesis / retinal degeneration / three dimensional stacked technology / rabbits / 遺伝性網膜疾患 / DNA診断 / 遺伝子工学 / 色盲 / 制限酵素断片長多型 / Hereditary diseases / Diagnosis / Molecular biology / Photo receptor cells / Pigment epithelium / 眼球運動 / 筋萎縮性側索硬化症 / 意志の交流 / ワ-ドプロセッサ- / 眼振図 / 二次元位置計測装置 / ワ-ドプロセッサ / ワードプロセッサー / ocular movement / amyotrophic lateral sclerosis / interchange of will / Word processor / EOG / two-dimensional position measuring device / 網膜疾患 / 網膜特異抗原 / 網膜特異的cDNAクロ-ン / S抗原 / カテプシンD / 神経網膜 / 網膜色素上皮細胞 / 網膜抗原 / 抗網膜抗体 / Retinal Disoeders / Retina specific antigens / Molecular Biology / Retina specific cDNA clones / ウシ網膜 / レチノ-ル脱水素酵素 / 精製 / 基質立体特異性 / 免疫組織化学 / 固相酵素免疫測定法 / 視細胞変性症 / ビタミンA / 酵素免疫組織化学 / 膜酵素 / 単クロ-ン抗体 / Bovine Retima / Rod Outer Segments / Retinol Dehydrogenase / Purification / Stereospecificity / Immunohisto chemisrty / Enzyme-Linked Immunosorbent Assay / Retinal Degeneration Less

Establishment of a method for restoring vision using light-gated ion channels and the promotion of optogeneticsPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
- Research Field
  
  Ophthalmology
  Biomedical engineering/Biological material science
- Research Institution
  Tohoku University
光感受性遺伝子を用いた新しい神経節細胞の機能評価法の確立
- Principal Investigator
  
  富田浩史
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
サルを用いた人工視覚の行動学的解析Principal Investigator
- Principal Investigator
  
  玉井信
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Basic studies of three dimensionally stacked retinal prosthesis toward for clinical trials
- Principal Investigator
  
  TOMITA Hiroshi
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Evaluation of protective and adverse effects of gene transferred IPE cell transplantation on degenerative retinal diseasesPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
人に移植可能な1チップ薄膜化人工眼の開発
- Principal Investigator
  
  栗野浩之
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  電子デバイス・機器工学
- Research Institution
  Tohoku University
眼組織における有機アニオントランスポーターの発現と機能の解析
- Principal Investigator
  
  YAMAGUCHI Katsuhiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Instrument capable of grading eyes with severe visual loss: Estimation of visual function utilizing a novel device called the Low Vision Evaluator
- Principal Investigator
  
  NAKAGAWA Yoichi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
TREATMENT OF RETINAL DEGENERATIVE DISIESE BY TRANSPLANTATION OF GENE TRANSFERRED CELLSPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  TOHOKU UNIVERSITY
Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration : basic and clinical researchPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Basic research for clinical application of retina and optic nerve regeneration by transplantationPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1995 – 1997
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Treatment of ischemic retinal injury by administration of various cytokines through vitreous cavity.Principal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Regeneration of pigment cells and basic and clinical study for treatment of age-related macular degenerationPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
OCULAR CIRCULATION AND INNERVATIO
- Principal Investigator
  
  KARITA Keishiro
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  TOHOKU UNIVERSITY
Basic study of optic nerve regeneration by transplantation for clinical application
- Principal Investigator
  
  FUKUDA Yutaka
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka University
Analysis of photoreceptor cell-specific retinol dehydrogenase gene in the patient with retinitis pigmentosa.
- Principal Investigator
  
  ISHIGU Sei-ichi
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Molecular Biological Research for Retinitis Pigmentosa
- Principal Investigator
  
  NAKAZAWA Mitsuru
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
網膜構築と視神経再生の細胞分子生物学
- Principal Investigator
  
  FUKUDA Yutaka
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for Co-operative Research (B)
- Research Field
  
  Neurophysiology and muscle physiology
- Research Institution
  Osaka University
Molecular Biological Approach to Hereclitay Detinoclsotdal Disorders
- Principal Investigator
  
  SHIONO Takashi
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku Univresity
EXPRESSION AND FUNCTION OF STRESS PROTEIN IN THE OCULAR TISSUE
- Principal Investigator
  
  YAMAGUCHI Katsuhiro
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  tOHOKU UNIVERSITY
Basic and clinical approach for analysis and treatment of the age related neovascular maculopathyPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Ophthalmology
- Research Institution
  TOHOKU UNIVERSITY
Molecular Biological Research for Retinitis Pigmentosa
- Principal Investigator
  
  NAKAZAWA Mitsuru
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Clinical research for Visual disturbance in Multi infarct denentia
- Principal Investigator
  
  KIYOSAWA Motohiro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku Unviersity
Molecular Biological Research for Hereditary Retinal DegenerationPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Research for Anti-Retinal Antibody in Retinal Disorders
- Principal Investigator
  
  NAKAZAWA Mitsuru, 原敏
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Purification and Immunohistochemistry of Retinol Dehydrogenase From Bovine Retinal Rod Outer Segments.
- Principal Investigator
  
  ISHIGURO Sei-ichi
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
Development of Image Processing System for Fundus Video-Angiography with Non-Stroboscopic IlluminationPrincipal Investigator
- Principal Investigator
  
  TAMAI Makoto
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B).
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University
DNA-diagnosis and standardization of hereditary retial diseases.
- Principal Investigator
  
  MIKI Naomasa
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  Ophthalmology
- Research Institution
  Osaka University Medical School
  Kanazawa University
Prototype word processor operable by ocular movement.
- Principal Investigator
  
  TSUKAHARA Yasuo
- Project Period (FY)
  1987 – 1989
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research
- Research Field
  
  医学一般
- Research Institution
  TOHOKU UNIVERSITY
網膜の器官培養におけるオプシン形成:基礎的研究および臨床薬理学への応用Principal Investigator
- Principal Investigator
  
  玉井信
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Ophthalmology
- Research Institution
  Tohoku University

All 2012 2011 2010 2009 2008 2007 2004 2000

All Journal Article Presentation Book Patent

[Book] 臨床眼科増刊号網膜硝子体診療update2008
- Author(s)
  富田浩史、菅野江里子、玉井信
- Publisher
  医学書院
- Data Source
  KAKENHI-PROJECT-19659442
[Journal Article] Age-dependent differences in recovered visual responses in Royal College of Surgeons rats transduced with the Channelrhodopsin-2 gene.2012
- Author(s)
  Isago H, Sugano E, Wang Z, Murayama N, Tamai M, Tomita H.
- Journal Title
  
  J Mol Neurosci
  
  Volume: 46(2) Pages: 393-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Age-Dependent Differences in Recovered Visual Responses in Royal College of Surgeons Rats Transduced with the Channelrhodopsin-2 Gene2011
- Author(s)
  Isago H, Sugano E, Wang Z, Murayama N, Koyanagi E, Tamai M, Tomita H
- Journal Title
  
  J Mol Neurosci
  
  Volume: 46(2) Pages: 393-400
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Immune responses to adeno-associated virus type 2 encoding channelrhodopsin-2 in a genetically blind rat model for gene therapy.2011
- Author(s)
  Sugano E, Isago H, Wang Z, Murayama N, Tamai M, Tomita H.
- Journal Title
  
  Gene Therapy
  
  Volume: 18(3) Pages: 266-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Differentiation of neuronal cells from NIH/3T3 fibroblasts under defined conditions2011
- Author(s)
  Wang Z, Sugano E, Isago H, Hiroi T, Tamai M, Tomita H
- Journal Title
  
  Dev Growth Differ
  
  Volume: 53(3) Pages: 357-65
- NAID
  10028202629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Differentiation of neuronal cells from NIH/3T3 fibroblasts under defined conditions.2011
- Author(s)
  Wang Z, Sugano E, Isago H, Hiroi T, Tamai M, Tomita H.
- Journal Title
  
  Development Growth and Differentiation
  
  Volume: 53(3) Pages: 357-65
- NAID
  10028202629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Differentiation of neuronal cells from NIH/3T3 fibroblasts under defined conditions2011
- Author(s)
  Wang Z, Sugano E, Isago H, Hiroi T, Tamai M, Tomita H.
- Journal Title
  
  Development Growth and Differentiation
  
  Volume: (未定印刷中)
- NAID
  10028202629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Channelrhodopsin-2 Gene Transduced into Retinal Ganglion Cells Restores Functional Vision in Genetically Blind Rats2010
- Author(s)
  Tomita H, Sugano E, Isago H, Hiroi T, Wang Z, Ohta E, Tamai M.
- Journal Title
  
  Exp Eye Res 90
  
  Pages: 426-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats.2010
- Author(s)
  Tomita H, Sugano E, Isago H, Hiroi T, Wang Z, Ohta E, Tamai M.
- Journal Title
  
  Exp Eye Res
  
  Volume: 90 Pages: 426-436
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Immune responses to adeno-associated virus type 2 encoding channelr hodopsin-2 in a genetically blind rat model for gene therapy.2010
- Author(s)
  Sugano E, Isago H, Wang Z, Murayama N, Tamai M, Tomita H.
- Journal Title
  
  Gene Therapy
  
  Volume: 18(3) Pages: 266-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the Thy-1.2 promoter.2009
- Author(s)
  Tomita H, Sugano E, Fukazawa Y, Isago H, Sugiyama Y, Hiroi T, Ishizuka T, Mushiake H, Kato M, Hirabayashi M, Shigemoto R, Yawo H, Tamai M.
- Journal Title
  
  PLoS ONE
  
  Volume: 4(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Channelrhodopsins provide a breakthrough insight into strategies for curing blindness2009
- Author(s)
  Tomita H, Sugano E, Isago H, Tamai M
- Journal Title
  
  J Genetics 88
  
  Pages: 409-415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Visual Properties of Transgenic Rats Harboring the Channelrhodopsin-2 Gene regulated by the Thy-1.2 Promoter2009
- Author(s)
  Tomita H, Sugano E, Fukazawa Y, Isago H, Sugiyama Y, Hiroi T, Ishizuka T, Mushiake H, Kato M, Hirabayashi M, Shigemoto R, Yawo H, Tamai M
- Journal Title
  
  PLoS ONE 4(11)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Channelrhodopsins provide a breakthrough insight into strategies for curing blindness.2009
- Author(s)
  Tomita H, Sugano E, Isago H, Tamai M.
- Journal Title
  
  J Genetics
  
  Volume: 88 Pages: 409-415
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21200022
[Journal Article] Retinal Prosthesis System with Telemetry Circuit Controlled by Human Eyelid Movement2004
- Author(s)
  Jun Deguchi, Hiroyuki Kurino, Makoto Tamai, Mitsumasa Koyanagi, et al.
- Journal Title
  
  Extended Abstracts of the 2004 International Conference on Solid State Devices and Materials
  
  Pages: 350-351
- NAID
  10022538727
- Data Source
  KAKENHI-PROJECT-14205051
[Journal Article] An instrument capable of grading visual function : results from patients with retinitis pigmentosa.2004
- Author(s)
  Tamai M, Kunikata H, Itabashi T, et al.
- Journal Title
  
  Tohoku J Exp Med 203
  
  Pages: 305-312
- NAID
  10013349534
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Novel 615de1C mutation in the CRX gene in a Japanese family with cone-rod dystrophy2004
- Author(s)
  Itabashi T, Wada Y, Sato H, Kawamura M, Shiono T, Tamai M
- Journal Title
  
  Am J Ophthalmol 138
  
  Pages: 876-877
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] An instrument capable of grading visual function : results from patients with retinitis pigmentosa2004
- Author(s)
  Tamai M, Kunikata H, Itabashi T, et al.
- Journal Title
  
  Tohoku J Exp Med 203
  
  Pages: 305-312
- NAID
  10013349534
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Progress in pathogenesis and therapeutic research in retinitis pigmentosa and age-related macular degeneration2004
- Author(s)
  Tamai M
- Journal Title
  
  Nippon Ganka Gakkai Zasshi 108
  
  Pages: 750-768
- NAID
  10014386693
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Clinical features of Japanese families with a 402delT or a 555-556delAG mutation in choroideremia gene.2004
- Author(s)
  Itabashi T, Wada Y, Kawamura M, Sato H, Tamai M
- Journal Title
  
  Retina 24
  
  Pages: 940-945
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Clinical features of a Japanese family with autosomal dominant retinitis pigmentosa associated with a Thr494Met mutation in the HPRP3 gene2004
- Author(s)
  Wada Y, Itabashi T, Sato H, Tamai M
- Journal Title
  
  Greafes Arch Clin Exp Ophthalmol 242
  
  Pages: 956-961
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Transplantation of transduced retinal pigment epithelium in rats.2004
- Author(s)
  Saigo Y, Abe T, Hojo M, Tomita H, Sugano E, Tamai M
- Journal Title
  
  Invest Ophthalmol Vis Sci 45
  
  Pages: 1996-2004
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Clinical features of Japanese families with a 402delT or a 555-556delAG mutation in choroideremia gene2004
- Author(s)
  Itabashi T, Wada Y, Kawamura M, Sato H, Tamai M
- Journal Title
  
  Retina 24
  
  Pages: 940-945
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Novel 615delC mutation in the CRX gene in a Japanese family with cone-rod dystrophy2004
- Author(s)
  Itabashi T, Wada Y, Sato H, Kawamura M, Shiono T, Tamai M
- Journal Title
  
  Am J Ophthalmol 138
  
  Pages: 876-877
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Clinical features of a Japanese family with autosomal dominant retinitis pigmentosa associated with a Thr494Met mutation in the HPRP3 gene.2004
- Author(s)
  Wada Y, Itabashi T, Sato H, Tamai M
- Journal Title
  
  Graefes Arch Clin Exp Ophthalmol 242
  
  Pages: 956-961
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Transplantation of transduced retinal pigment epithelium in rats2004
- Author(s)
  Saigo Y, Abe T, Hojo M, Tomita H, Sugano E, Tamai M
- Journal Title
  
  Invest Ophthalmol Vis Sci 45
  
  Pages: 1996-2004
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15390524
[Journal Article] Analysis of the metallothionein gene in age-related macular degeneration.2000
- Author(s)
  Sato M, Abe T, Tamai M.
- Journal Title
  
  Japanese Journal of Ophthalmology. 44
  
  Pages: 115-121
- NAID
  10013262582
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307041
[Journal Article] A new Leu253Arg mutation in the RP2 gene in a Japanese family with X-linked retinitis pigmentosa.2000
- Author(s)
  Wada Y, Nakazawa M, Abe T, Tamai M.
- Journal Title
  
  Investigative Ophthalmology & Visual Science. 41
  
  Pages: 290-293
- NAID
  40019976427
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307041
[Journal Article] Variable R1 region in varicella tester virus in fulminant type of acute retinal necrosis syndrome.2000
- Author(s)
  Abe T, Sato M, Tamai M.
- Journal Title
  
  British Journal of Ophthalmology. 85
  
  Pages: 193-198
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-10307041
[Patent] 遺伝子導入による視覚機能の再建方法2007
- Inventor(s)
  富田浩史、玉井信、菅野江里子
- Industrial Property Rights Holder
  富田浩史、玉井信、菅野江里子
- Filing Date
  2007-03-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390465
[Presentation] ボルボックス由来チャネルロドプシン1遺伝子改変による感受波長の改善2011
- Author(s)
  菅野江里子、砂金ひとみ、村山なみえ、玉井信、富田浩史
- Organizer
  第82回日本動物学会
- Place of Presentation
  旭川
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Visual properties of genetically blind rats transduced with channelrhodopsin-2 gene2011
- Author(s)
  Tomita H, Sugano E, Isago H, Murayama N, Wang Z, Tamai M
- Organizer
  The 16th Congress of chinese Ophthalmological Society
- Place of Presentation
  広州(中国)
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] 遺伝子導入による視覚再建2011
- Author(s)
  富田浩史, 菅野江里子, 砂金ひとみ, 王卓, 村山なみえ, 玉井信
- Organizer
  日本視覚学会
- Place of Presentation
  東京
- Year and Date
  2011-01-20
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Effective Time Point For Channelrhodopsin-2 mediated Gene Therapy After Photoreceptor Degeneration In Rcs Rats2011
- Author(s)
  Sugano E, Isago H, Wang Z, Murayama N, Tamai M, Tomita H
- Organizer
  ARVO Annual meeting
- Place of Presentation
  Fortlauderdale, FL
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] チャネルロドプシン2を用いた視覚の再生について2011
- Author(s)
  菅野江里子、砂金ひとみ、玉井信、富田浩史
- Organizer
  JRPS（網膜色素変性症協会）新潟支部医療講演会
- Place of Presentation
  新潟市
- Year and Date
  2011-05-22
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] チャネルロドプシン2を導入した週齢の異なるRCSラットの視覚反応の違い2011
- Author(s)
  砂金ひとみ、菅野江里子、村山なみえ、玉井信、富田浩史
- Organizer
  第82回日本動物学会
- Place of Presentation
  旭川
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] 視細胞変性モデルの確立2011
- Author(s)
  富田浩史、菅野江里子、砂金ひとみ、村山なみえ、玉井信
- Organizer
  第82回日本動物学会
- Place of Presentation
  旭川
- Year and Date
  2011-09-21
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Gene therapy in opjtjalmology `Visual properties of genetically blind rats transduced with channelrhodopsin-2 gene."2011
- Author(s)
  Tomita H, Sugano E, Isago H, Murayama N, Wang Z, Tamai M
- Organizer
  The Fourth Global Chinese Ophthalmic conference, The 16th Congress of chinese Ophthalmological Society
- Place of Presentation
  広州（中国）
- Year and Date
  2011-09-08
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] mprovement Of Wavelength Sensitivities By The Modification Of Volvox Channelrhodopsin-1 Gene2011
- Author(s)
  Tomita H, Sugano E, Isago H, Murayama N, Wang Z, Tamai M
- Organizer
  ARVO Annual meeting
- Place of Presentation
  Fortlauderdale, FL
- Year and Date
  2011-05-01
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Optimization of volvox-derived channelrhodopsin-1 to expressexpression in mammalian cells2010
- Author(s)
  Sugano, E., Tomita, H., Isago, H., Hiroi, T., Wang, Z. and Tamai, M
- Organizer
  XIVth International Symposium on Retinal Degeneration
- Place of Presentation
  Quebec, Canada
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] 藻類由来遺伝子を用いた視覚再生技術2010
- Author(s)
  富田浩史, 菅野江里子, 砂金ひとみ, 王卓, 村山なみえ, 玉井信
- Organizer
  日本人工臓器学会
- Place of Presentation
  仙台
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Systematic and Local Responses of Channelrhodopsin-2 Gene Therapy2010
- Author(s)
  Sugano, E., Tomita, H., Isago, H., Hiroi, T., Wang, Z., Tamai, M.
- Organizer
  Annual meeting Association for Research in Vision and Ophthalmology
- Place of Presentation
  Ft.Lauderdale, US
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Retinal and systemic immune responses after the transfer of channelrhodopsin-2 into RCS rats2010
- Author(s)
  Tomita, H., Sugano, E., Isago, H., Hiroi, T., Wang, Z. and Tamai, M
- Organizer
  XIVth International Symposium on Retinal Degeneration
- Place of Presentation
  Quebec, Canada
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] 緑藻類由来遺伝子を用いた視覚再生技術2010
- Author(s)
  富田浩史, 菅野江里子, 砂金ひとみ, 王卓, 村山なみえ, 玉井信
- Organizer
  日本人工臓器学会
- Place of Presentation
  仙台
- Year and Date
  2010-11-20
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Visual Responses of Royal College of Surgeons Rats Transferred Modified Volvox Channelrhodopsin-2 Gene.2010
- Author(s)
  Tomita, H., Sugano, E., Isago, H., Hiroi, T., Wang, Z., Tamai, M.
- Organizer
  Annual meeting Association for Research in Vision and Ophthalmology
- Place of Presentation
  Ft.Lauderdale, US
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Systematic and Local Responses of Channelrhodopsin-2 Gene Therapy2010
- Author(s)
  Sugano, E., Tomita, H., Isago, H., Hiroi, T., Wang, Z. and Tamai, M
- Organizer
  Annual meeting Association for Research in Vision and Ophthalmology
- Place of Presentation
  Ft. Lauderdale, US
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Visual Responses of Royal College of Surgeons Rats Transferred Modified Volvox Channelrhodopsin-2 Gene.2010
- Author(s)
  Tomita, H., Sugano, E., Isago, H., Hiroi, T., Wang, Z. and Tamai, M
- Organizer
  nnual meeting Association for Research in Vision and Ophthalmology
- Place of Presentation
  Ft. Lauderdale, US
- Year and Date
  2010-05-02
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Properties of Recovered Visual Function in the Channelrhodopsin-2 Transferred Royal College of Surgeons Rats2009
- Author(s)
  H.Tomita, E.Sugano, H.Isago, T.Hiroi, H.Yawo, M.Tamai
- Organizer
  Association for Research Vision and Ophthalmology
- Place of Presentation
  Ft.Lauderdale, FL, US
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Visual Function of Wild Type and Channelrhodopsin-2 Transgenic Rats2009
- Author(s)
  E.Sugano, H.Tomita, H.Isago, H.Yawo, Y.Fukazawa, R.Shigemoto, T.Hiroi, M.Kato, M.Hirabayashi, M.Tamai
- Organizer
  Association for Research Vision and Ophthalmology
- Place of Presentation
  Ft.Lauderdale, FL, US
- Year and Date
  2009-05-03
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] Channelrhodopsin-2トランスジェニックラットの視機能について2009
- Author(s)
  砂金ひとみ, 富田浩史, 菅野江里子, 廣井照, 王卓, 玉井信
- Organizer
  日本動物学会
- Place of Presentation
  静岡
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-21200022
[Presentation] カニクイザルを用いた視機能評価2009
- Author(s)
  菅野江里子、富田浩史、姫志剛、砂金ひとみ、廣井照、松坂昌哉、虫明元、玉井信
- Organizer
  日本動物学会
- Place of Presentation
  静岡
- Year and Date
  2009-09-19
- Data Source
  KAKENHI-PROJECT-21200022

1. TOMITA Hiroshi (40302088)

# of Collaborated Projects: 8 results

# of Collaborated Products: 37 results
2. ISHIGURO Sei (20111271)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
3. YAMAGUCHI Katsuhiro (20200610)

# of Collaborated Projects: 4 results

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4. SUGANO Eriko (70375210)

# of Collaborated Projects: 4 results

# of Collaborated Products: 35 results
5. NAKAZAWA Mitsuru (80180272)

# of Collaborated Projects: 4 results

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6. SATO Hajime (10312571)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
7. YAMADA Takahoko (40191316)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. NAKAGAWA Youichi (10282063)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. FUKUDA Yutaka (90028598)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. SAITO Takehiko (20081630)

# of Collaborated Projects: 3 results

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11. ABE Toshiaki (90191858)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
12. ISAGO Hitomi (30400451)

# of Collaborated Projects: 3 results

# of Collaborated Products: 34 results
13. WAKAKURA Masato (50137931)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. CHIDA Yasushi (70250777)

# of Collaborated Projects: 2 results

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15. WADA Yuko (70302130)

# of Collaborated Projects: 2 results

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16. FUSE Nobuo (10302134)

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17. TASAKI Kyoji (10004532)

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19. 佐藤まなみ (80375211)

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21. 原敏 (60108537)

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22. IMAMURA Kazuyuki (30203326)

# of Collaborated Projects: 1 results

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23. WATANABE Masami (10093486)

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24. KIYOSAWA Motohiro (20169957)

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25. SHIONO Takashi (20133978)

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26. HORIE Hidenori (80046135)

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27. TAKAHASHI Hiroshi (00129511)

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28. YUSUF Durlu K (90250787)

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29. KARITA Keishiro (40004600)

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30. IZUMI Hiroshi (20108541)

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31. ARAKI Masasuke (00118449)

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32. TAUCHI Masaki (00075425)

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33. OHKI Kazuo (80115394)

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34. TAKEDA Atushi (70261534)

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35. MIKI Naomasa (40094445)

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37. NAKAZIMA Akira (90052927)

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38. KAWASAKI Kazuo (20019920)

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39. OHBA Norio (50010070)

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40. TSUKAHARA Yasuo (60004587)

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41. SAITO Hiroshi (80004711)

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# of Collaborated Projects: 1 results

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56. MUTOH Tsutomu

# of Collaborated Projects: 1 results

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57. 君塚佳宏

# of Collaborated Projects: 1 results

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58. 荒川明

# of Collaborated Projects: 1 results

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59. 小嶋伸吾

# of Collaborated Projects: 1 results

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TAMAI Makoto 玉井 信

王井 信 タマイ マコト

五井 信

Research Projects

Research Products

Co-Researchers

Establishment of a method for restoring vision using light-gated ion channels and the promotion of optogeneticsPrincipal Investigator

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サルを用いた人工視覚の行動学的解析Principal Investigator

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Evaluation of protective and adverse effects of gene transferred IPE cell transplantation on degenerative retinal diseasesPrincipal Investigator

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TREATMENT OF RETINAL DEGENERATIVE DISIESE BY TRANSPLANTATION OF GENE TRANSFERRED CELLSPrincipal Investigator

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Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration : basic and clinical researchPrincipal Investigator

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Basic research for clinical application of retina and optic nerve regeneration by transplantationPrincipal Investigator

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Treatment of ischemic retinal injury by administration of various cytokines through vitreous cavity.Principal Investigator

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Regeneration of pigment cells and basic and clinical study for treatment of age-related macular degenerationPrincipal Investigator

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Principal Investigator

TAMAI Makoto 玉井信

王井信タマイマコト

五井信